#eric jungmann

[mystery-meat-with-cheese]

conservatives when they're losing an argument

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WATCHLIST 2022: Not Another Teen Movie

[junkyarddemento]

BODY OF THE MINED

I’m not entirely sure what’s happening here, and that’s okay, as the story and performances from the cast are strong and captivating. Grounded science fiction or DIY Sci-Fi, as a plot, is always interesting whether it’s building a time machine or some kind of super weapon. Actor/Writer/Director Eric Jungmann is able to throw all the budget on screen, utilizing amazing production design, crisp cinematography and practical effects, that combined, give the viewer a hearty thrilling viewing experience. 

[stillsmybeatingheart]

[jamieroxx]

Happy Birthday. Today, Dec 2, 1981 – Eric Jungmann, American actor was born. (https://en.wikipedia.org/wiki/Eric_Jungmann)

[movie-titlecards]

Monster Man (2003)

My rating: 2/10

The ending almost makes up for the hour of insufferable garbage that comes before it, but it doesn't. This is shit.

[cultfaction]

Preview: Monster Man (Bluray)

Preview: Monster Man (Bluray)

Directed by Michael Davis, Monster Man stars Eric Jungmann, Justin Urich, and Aimee Brooks. Monster trucks have gigantic wheels, carriages of steel, tons of horsepower and crush anything in their way. On desolate I-55 there is one monster truck that gives new meaning to the name. It’s not just the truck that is monstrous. So is the driver. When two college buddies driving cross-country stumble…

[thepeoplesmovies]

Sunday Short Theatre - Body Of The Mined (2021)

Sunday Short Theatre - Body Of The Mined (2021) #SundayShortTheatre #short #EricJungmann

This weeks Sunday Short Theatre could leave you with one of those “What if…” scenarios if you got your hands on the machine in question. Eric Jungmann‘s Body Of The Mined finds us in a violent world, theft is rife how can you keep things hidden? Or is this a film about identity or even sacrifice? Jungmann’s 15 minute sci-fi short is his his directorial debut. After 20 plus years acting, like many…

[moremoviesplease]

Killer Pad (2008)

Dir. Robert Englund

☆Daniel Franzese, Eric Jungmann, Shane McRae☆

[yifysubtitlescc]

Parallels Any Langage Subtitles Download

https://zooqle.biz/movie/parallels-2015-subtitles

Parallels (2015)Action / Sci-Fi / • 83 minutesStarring: Mark Hapka Jessica Rothe Eric Jungmann Constance Wu and others.Writer: Laura Harkcom (story) Christopher Leone (story) Christopher Leone (teleplay)Released • 01 Mar 2015

[goalhofer]

2017 Milwaukee Brewers Roster

Pitchers

#57 Chase Anderson (Wichita Falls, Texas)

#50 Jacob Barnes (St. Petersburg, Florida)

#27 Zach Davies (Gilbert, Arizona)

#37 Neftali Feliz (Azua, Dominican Republic)

#22 Matt Garza (Easton, California)

#41 Junior Guerra (San Felix, Venezuela)

#48 Jared Hughes (San Marino, California)

#26 Taylor Jungmann (Rogers, Texas)

#46 Corey Knebel (Georgetown, Texas)

#53 Jhan Marinez (Santo Domingo, Dominican Republic)

#33 Tommy Milone (Saugus, California)

#52 Jimmy Nelson (Niceville, Florida)

#38 Wily Peralta (Santo Domingo, Dominican Republic)

#35 Brent Suter (Cincinnati, Ohio)

#59 Carlos Torres (Santa Cruz, California)

Catchers

#47 Jett Bandy (Thousand Oaks, California)

#9 Manny Pina (Barquisimeto, Venezuela)

#13 Andrew Susac (Carmichael, California)

Infielders

#24 Jesus Aguilar (Maracay, Venezuela)

#3 Orlando Arcia (Anaco, Venezuela)

#14 Hernan Perez (San Francisco De Asis, Venezuela)

#21 Travis Shaw (Washington Court House, Ohio)

#7 Eric Thames (San Jose, California)

#5 Jonathan Villar (La Vega, Dominican Republic)

Outfielders

#8 Ryan Braun (Los Angeles, California)

#23 Keon Broxton (Lakeland, Florida)

#10 Kirk Nieuwenhuis (Lakewood, Colorado)

#16 Domingo Santana (Santo Domingo, Dominican Republic)

[wincatcherses]

Rangers liberan 37 jugadores menores de liga

Los Rangers han lanzado 37 jugadores de ligas menores, según informes de TR Sullivan de MLB.com y Evan Grant de Dallas Morning News. El tweet de Grant contiene la lista completa, que incluye a los diestros Austin Bibens-Dirkx y Taylor Jungmann y al jardinero Eric Jenkins, por nombrar algunos. El bien viajado Bibens-Dirkx, que ha tenido varias paradas en América del Norte y ha jugado en China, es un nombre familiar para los fanáticos de los Rangers. Originalmente elegido en la ronda 16 de los Marineros en 2006, hizo su debut en las Grandes Ligas con Texas en 2017 y también lanzó para el club la próxima temporada. Hasta este punto, el jugador de 35 años es dueño de una efectividad de 5.27 / 5.63 FIP con 5.59 K / 9 y 2.68 BB / 9 en 114 1/3 entradas de Grandes Ligas. Bibens-Dirkx pasó parte de 2019 como parte del equipo Triple-A de los Rangers, con el que luchó para lograr una efectividad de 7.98 en 38 1/3 cuadros. Jungmann, de 30 años, fue una selección de primera ronda de 2011 (No. 12, Cerveceros) que descifró las 100 mejores listas de prospectos en su juventud, pero solo logró una efectividad de 4.54 en 146 2/3 entradas como Cervecero de 2015-17. Pasó las dos temporadas anteriores lanzando en Japón. Jenkins también fue una gran selección (una segunda ronda en 2015), pero el velocista no golpeó lo suficiente en los menores para que los Rangers lo mantuvieran en el redil. El jugador de 23 años no ha superado la pelota High-A, donde bateó .176 / .270 / .278 con una tasa de ponches de 32.2 por ciento y 21 robos en 295 apariciones en el plato en 2019.

from Noticias Wincatchers https://noticias.wincatchers.com/2020/06/02/rangers-liberan-37-jugadores-menores-de-liga/

[dorcasrempel]

Technique can image individual proteins within synapses

Our brains contain millions of synapses — the connections that transmit messages from neuron to neuron. Within these synapses are hundreds of different proteins, and dysfunction of these proteins can lead to conditions such as schizophrenia and autism.

Researchers at MIT and the Broad Institute of Harvard and MIT have now devised a new way to rapidly image these synaptic proteins at high resolution. Using fluorescent nucleic acid probes, they can label and image an unlimited number of different proteins. They demonstrated the technique in a new study in which they imaged 12 proteins in cellular samples containing thousands of synapses.

“Multiplexed imaging is important because there’s so much variability between synapses and cells, even within the same brain,” says Mark Bathe, an MIT associate professor of biological engineering. “You really need to look simultaneously at proteins in the sample to understand what subpopulations of different synapses look like, discover new types of synapses, and understand how genetic variations impact them.”

The researchers plan to use this technique next to study what happens to synapses when they block the expression of genes associated with specific diseases, in hopes of developing new treatments that could reverse those effects.

Bathe and Jeff Cottrell, director of translational research at the Stanley Center for Psychiatric Research at the Broad Institute, are the senior authors of the study, which appears today in Nature Communications. The lead authors of the paper are former postdocs Syuan-Ming Guo and Remi Veneziano, former graduate student Simon Gordonov, and former research scientist Li Li.

Imaging with DNA

Synaptic proteins have a variety of functions. Many of them help to form synaptic scaffolds, which are involved in secreting neurotransmitters and processing incoming signals. While synapses contain hundreds of these proteins, conventional fluorescence microscopy is limited to imaging at most four proteins at a time.

To boost that number, the MIT team developed a new technique based on an existing method called DNA PAINT. Using this method, originally devised by Ralf Jungmann of the Max Planck Institute of Biochemistry, researchers label proteins or other molecules of interest with a DNA-antibody probe. Then, they image each protein by delivering a fluorescent DNA “oligo” that binds to the DNA-antibody probes.

The DNA strands have an inherently low affinity for each other, so they bind and unbind periodically, creating a blinking fluorescence can be imaged using super-resolution microscopy. However, imaging each protein takes about half an hour, making it impractical for imaging many proteins in a large sample.

Bathe and his colleagues set out to create a faster method that would allow them to analyze a huge number of samples in a short period of time. To achieve that, they altered the DNA-dye imaging probe so that it would bind more tightly to the DNA-antibody, using what are called locked nucleic acids. This gives a much brighter signal, so the imaging can be done more quickly, but at slightly lower resolution.

“When we do 12 or 15 colors on a single well of neurons, the whole experiment takes an hour, compared with overnight for the super-resolution equivalent,” Bathe says.

The researchers used this technique to label 12 different proteins found in the synapse, including scaffolding proteins, proteins associated with the cytoskeleton, and proteins that are known to mark excitatory or inhibitory synapses. One of the proteins they looked at is shank3, a scaffold protein that has been linked to both autism and schizophrenia.

By analyzing protein levels in thousands of neurons, the researchers were able to determine groups of proteins that tend to associate with each other more often than others, and to learn how different synapses vary in the proteins they contain. That kind of information could be used to help classify synapses into subtypes that might help to reveal their functions.

“Inhibitory and excitatory are the canonical synapse types, but it is speculated that there are numerous different subtypes of synapses, without any real consensus around what those are,” Bathe says.

Understanding disease

The researchers also showed that they could measure changes in synaptic protein levels that occur after neurons are treated with a compound called tetrodotoxin (TTX), which strengthens synaptic connections.

“Using conventional immunofluorescence, you can typically extract information from three or four targets within the same sample, but with our technique, we were able to expand that number to 12 different targets within the same sample. We applied this method to examine synaptic remodeling that occurs following treatment with TTX, and our finding corroborated previous work that revealed a coordinated upregulation of synaptic proteins following TTX treatment,” says Eric Danielson, an MIT senior postdoc who is an author of the study.

The researchers are now using this technique, called PRISM, to study how the structure and composition of synapses are affected by knocking down a set of genes reported previously to confer genetic risk for development of psychiatric disorders. Sequencing the genomes of people with disorders such as autism and schizophrenia has revealed hundreds of disease-linked gene variants, and for most of those variants, scientists have no idea how they contribute to disease.

“With this approach, we expect to provide a more detailed overview of the changes in synaptic organization and shared disease effects associated with these genes,” says Karen Perez de Arce, a Broad Institute research scientist and an author of the study.

“Understanding how genetic variation impacts neurons’ development in the brain, and their synaptic structure and function, is a huge challenge in neuroscience and in understanding how these diseases arise,” Bathe adds.

The research was funded by the National Institutes of Health, including the NIH BRAIN Initiative, the National Science Foundation, the Howard Hughes Medical Institute Simons Faculty Scholars Program, the Open Philanthropy Project, the U.S. Army Research Laboratory, the New York Stem Cell Foundation Robertson Award, and the Stanley Center for Psychiatric Research.

Other authors of the paper include MIT research scientist Demian Park, former MIT graduate student Anthony Kulesa, and MIT postdoc Eike-Christian Wamhoff. Paul Blainey, an associate professor of biological engineering and a member of the Broad Institute, and Edward Boyden, the Y. Eva Tan Professor in Neurotechnology and an associate professor of biological engineering and of brain and cognitive sciences, are also authors of the study.

Technique can image individual proteins within synapses syndicated from https://osmowaterfilters.blogspot.com/

[babaalexander]

Great Birthday Wishes to Actors Born on December 2 Jacob Buster Alfred Enoch Horacio Pancheri Andre Kim, 20 Joe Lo Truglio Martin Barba Dude Harlino Boman Irani Dylan McLaughlin Bram Hoover Brendan Coyle Steven Bauer Dennis Christopher Lester Ellis Jr. Oliver Cooper Tom Prior Dan Butler Jonathan Frid (1924-2012) Jason Durr Dan Gauthier Bill Erwin (1914-2010) Joshua Seth Freedman Nick Cheung Keith Szarabajka Eric Jungmann Robert Paige (1911-1987) Leo Gordon (1922-2000) Warren William (1894-1948) Wilson Jermaine Heredia Ron Raines Alejandro Rae Jeremy Chabriel Alec B Francis (1867-1934) #JacobBuster #AlfredEnoch #HoracioPancheri #AndreKim #JoeLoTruglio #MartinBarba #DudeHarlino #BomanIrani #DylanMcLaughlin #BramHoover #BrendanCoyle #StevenBauer #DennisChristopher #LesterEllisJr #OliverCooper #TomPrior #DanButler #JonathanFrid (1924-2012) #JasonDurr #DanGauthier #BillErwin (1914-2010) #JoshuaSethFreedman #NickCheung #KeithSzarabajka #EricJungmann #RobertPaige (1911-1987) #LeoGordon (1922-2000) #WarrenWilliam (1894-1948) #WilsonJermaineHeredia #RonRaines #AlejandroRae #JeremyChabriel #AlecBFrancis (1867-1934)

[jamieroxx]

Happy Birthday. Today, Dec 2, 1981 – Eric Jungmann, American actor was born. (https://en.wikipedia.org/wiki/Eric_Jungmann)

[boreutattoo]

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