#inherited disease

[bpod-bpod]

Essential for Life

Cytoskeleton protein ARPC5 is important for prenatal development and for function of the immune system after birth – inheritance of a faulty ARPC5L gene causes early-onset immunodeficiency

Read the published research paper here

Image from work by Elena Sindram, Andrés Caballero-Oteyza and Naoko Kogata, and colleagues

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg Germany and Cellular Signalling and Cytoskeletal Function Laboratory, The Francis Crick Institute, London, UK

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Disease Models & Mechanisms, July 2023

You can also follow BPoD on Instagram, Twitter and Facebook

[unlawfulchaos]

*on comms during a training exercise*

Rooster: DADS, HELP!

Iceman: Don't worry Bradley, Mav's on his way, but you need to tell us your location.

Maverick: What are your coordinates, Baby Goose?

Rooster: I'm by a cloud that looks like a lion.

Iceman: Can you be more specific?

Rooster: Simba.

[guiltypandas]

It's that time of year where I redesign Tails' parents!

This year we got BIGGG changes--- including younger versions (bottom of 1st pic) of the two!

I just thought it would be funny to make them like theatre actors idkkkk! Give them something other than just "Tails' parents"

Plus a bonus doodle! Feel free to check out my previous designs for them! I improved way too much in a year HELP.

[northgirl09]

AU where Morzan has Hanahaki for Galbatorix

[wildstar25]

for ask game!

how does your wol sleep? very light? very heavy? do they need a specific item to fall asleep? is it easy for them to fall asleep, or does it take them forever? where do they prefer sleeping?

For Arsay it really depends on location! If she's at home, in bed, all cozy with her partners, she'll sleep like a log. Her preferred sleeping arrangement is sandwiched between Raha and Shtola. She can sleep just as well with only one of them present but its better with both.

Anywhere else and she'll sleep pretty lightly. I imagine it very similar to how most cats snooze away but are aware enough to wake up at the slightest change in their environment.

Arsay has always been able to fall asleep at the drop of a hat. Especially when on some type of transportation. She's better at staying awake on a ship, but put her on a caravan and she's out like a light. Those in transit naps are super vital for her keeping up the level of energy that she has. She's often more tired than she realizes!

[quietwingsinthesky]

for the ship ask game, have you ever thought about simm!master/eleven? would you like to?

would i ever!!!!!!

this was the basis of one of my posts about little amy so long ago. a hypothetical s5 where the master sticks with the doctor after he regenerates. but like can we talk about how insane that dynamic between him and amelia, the literal eight year old, would be. look at me. one of the defining things of eleven's run is that the first face he saw was amy's. seared onto his hearts!!! now, imagine that happens in a world where the master did everything right to be that person, and it was still amy. the tardis crashed, and the doctor went one way and the master went the other, and by the time the master drags himself soaking wet out of what was the swimming pool and into amelia's garden, the doctor is already having dinner with some random human child.

things simm!master is not above: being a little bitch to amy about this. yes, even when she's eight. (amelia pond with her stories about her magical raggedy doctor!! ...and the trash rat who crawled out of his time machine after him and threatened to eat her. wait okay hold on i know im getting distracted here but aslkjdalkjsd rory who amy makes dress up as the doctor vs mels who insists on dressing up as the master because she craves violence and an excuse to bite people.)

ANYWAY. god. eleven who is this bottomless well of grief and rage. and the master who is so much like him in this incarnation. silly goofy guys who burn too bright, burn up everything and everyone around them. what is simm!master if not a version of eleven untempered by kindness. i wonder what the master would have to say about a version of the doctor who is aware of how scared people are of him and uses it to his advantage. who scares the rest of the universe so much that they try to lock him away and kill him and do anything they can to get rid of him. when they lock the doctor up in the pandorica, does the master give him the final shove into the chair or is he a few feet away, just barely restrained, impotently snapping and snarling to prevent this?

but never looking at it directly, right? neither of them would be able to. not at what's between them, not at what came before. if you don't talk about that time you both saved each other, then maybe you can pretend it didn't happen.

i think the master would make eleven worse, no doubt about it. i think eleven might just make the master a little better, and he'd hate that but that wouldn't stop it from happening. they might find some sort of equilibrium, just this once, a little willing to bend in the aftermath of the events of the end of time. that part of the master that will be missy one day wakes up. the part of the doctor that was once the time lord victorious gets a last glorious breath. they can have that, together.

okay. okay. one last thing. gets ill thinking about eleven who is so physically affectionate being that way with the master. with mr 'im going to kiss my wife i married for political gain like im starving'. with mr 'time lord telepathy does not require physical contact but if we don't touch foreheads right now ill die'. with mr 'fuck u but also im gonna die in your arms, don't leave or let me go before everything falls quiet.' thinks about eleven touching him and hugging him and kissing him and- thinks about the master recoiling from it, hackles raised, or shoving the doctor away when he does. thinks about the doctor not stopping. thinks about the master getting accustomed to his touch, taking it greedily. (thinks about missy kissing the doctor to greet him later.)

yeag <3

[put any ship in my ask box and i’ll give my brutally honest opinion]

[simikae]

walk with me here guys. Can you read it? Do u get what im putting down ?

[tadpal]

reblogged the foundational girl+dog posts so that everyone can understand what's going on

[asiancatboy]

i'm for real turning into my mother 💀

[mantisgodsdomain]

Lycanthropy should count as a chronic illness.

[bpod-bpod]

Long Stretch

Mutations within the DNA code that cause abnormal stretches of an amino acid – for example alanine – are associated with a number of inherited diseases. This study reveals how polyalanine stretches have deleterious molecular effects

Read the published research paper here

Image from work by Fatima Amer-Sarsour and Daniel Falik, and colleagues

Department of Cell and Developmental Biology, Faculty of Medicine, Tel Aviv University; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in The EMBO Journal, January 2024

You can also follow BPoD on Instagram, Twitter and Facebook

[brown-little-robin]

What Do You Mean Ritsu Catches TheZombie Disease ?Whgat Do You Meanwhat do youmean whatg do u mean wh

:)

Well, here's the thing. Ritsu thinks Shigeo is no longer contagious. Even though he still has some zombie symptoms, like the misty eyes and the insomnia, he's officially cured. Everyone thinks Mob's symptoms are just leftovers, his body having been changed in ways you can't come back from.

The doctors are wrong. Mob still hosts a living (even thriving) disease colony. It's just that he lived with zombie disease so long that his body stopped fighting to eradicate the disease, and then the cure strengthened his immune system and allowed his body to push back against the disease, prioritizing clearing his brain while allowing the disease to remain part of him. And his disease colony, having the collective intelligence of a colony of bees, adapted to the situation.

Zoom out. Mob is living in a house with Ritsu. They don't really talk but they're in physical proximity. They eat together when they can. You'd think it would just be a matter of time until Ritsu got infected, but actually it didn't have to happen. Ritsu spent months taking care of Shige, Very Aware that he was going to be infected and doom them both if he came in contact with Shige's saliva. Ritsu still has the habits; he's still careful with everything he imbibes. He never drinks out of anything but his water bottle, he never takes food out of anything Shigeo has touched (Ritsu splits their food into separate meals BEFORE eating so that they never share a bowl), and he washes the sink before he uses it, every single time.

Mob doesn't use his old water bottle anymore. He drinks out of regular glasses, and he usually washes them himself. Sometimes he forgets, and then Ritsu steels himself and washes Shigeo's dishes and then washes his hands three times and takes a long bath.

So—it could have continued forever and no one would have known Mob was still contagious, because Ritsu treated him like he was still contagious anyway.

And then. The Big Cleanup arc happens. Ritsu and Kamuro are cleaning up Salt Township one useless delinquent at a time. Ritsu is pretty sure that someone recently tried to use his brother's zombie strength in inter-town warfare, and he is furious. He wishes everyone would forget about Nii-san. Unfortunately, though, in this au, there were witnesses to Teru and Mob's fight—some of the Black Vinegar delinquents were not unconscious for that. The rumors flew, and by the time Big Cleanup gets into full swing, people all around the former Seasoning City area know that there's a zombie kid from Salt who challenged Black Vinegar's secret weapon and won. Is Salt going to become a bandit town like Black Vinegar? They've been a good neighbor to the other fragments of Seasoning City so far, but if they have a zombie who can wreak that much destruction on command...

And the fact that Mob still has zombie symptoms—well. it's an open secret. So when Ritsu hears the rumor from Mezato, he knows perfectly well what's going to happen. People are going to come after his brother preemptively. Worst case scenario, Nii-san is going to get killed. Ritsu starts to consider taking Shigeo and making a run for it—leaving the Seasoning City area altogether, maybe. Striking out on their own again. He doesn't want to do it, but it might be their only chance. He feels rushed. someone could try something at any time.

So. when he hears from Mitsuura (who is essentially the same in this au, just,, a little more ethically questionable due to wanting zombie powers instead of psychic powers,,) that people who have been around zombies for a long time sometimes develop zombie characteristics, he thinks this might be his chance to stall. He thinks if he gets zombie strength, he could pretend to be White T Poison, to distract people from his brother long enough to—do something. figure out some way to protect his brother for real.

(The Awakening Lab kids have had long-term exposure to zombies and basically been immunized to the disease. they have had very, very mild cases and recovered with little damage. Rei Kurosaki can sense the presence of miasma and disease colony drones, for instance. Hoshino has above-average strength; Asahi has a permanent fever that makes him hot to the touch. Asahi in particular recently got bitten and never showed any symptoms. Ritsu watches and absorbs this information with Great interest.)

On Ritsu's way to Mitsuura's lab, which is just a little way outside Salt's territory, Student Council Vice President Tokugawa catches him and asks if he's alright. Tokugawa is perceptive, and although he disapproves of Ritsu and Kamuro's community "cleanup", he's noticed that Ritsu is doing. really bad. lately. He thinks maybe having someone Acknowledge that Ritsu is visibly doing bad and freaking out about his brother will help Ritsu gain some... solidity. Instead of telling Ritsu "stop acting like your brother", Tokugawa tells Ritsu, "Stop trying to take control of everything. You're not in charge of your brother anymore."

And that—that reference to Ritsu's months of caretaking just destroys what's left of Ritsu's desire to be normal. Not in charge of his brother anymore? Not in charge of his brother anymore? How dare he bring that up and suggest Ritsu just get over it? Ritsu's ability to be in control of everything is his best quality, thank you very much.

Ritsu goes to Mitsuura's lab, and then he comes home to find Shigeo asleep on the couch with a nearly empty glass of water by his hand.

Shigeo's not a zombie anymore—Tokugawa was right about that much. Ritsu doesn't have to be afraid of him this time. Ritsu is older, stronger, more in control this time than last time. He can do this.

He drinks the rest of Shigeo's water. On purpose.

(Shigeo's saliva is still contagious. his water has his disease drones in it, ready to clone themselves into a full colony. they find Ritsu's body very hospitable. very familiar. they start replicating the way they worked in their last host's body right away.)

[darkwood-sleddog]

look nothing but the best to these sort of people but I often see people get into mushing, acquire tons of dogs very quickly and then they commonly have accidental litters (or potentially purposeful...) on yearlings/very young dogs.

it is not cool.

[northgirl09]

I did a totally different Morzan from the first time, because I couldn't get it right and...

Well I'm pretty proud of it

[widowshill]

austen heroine of a man

[difeisheng]

.