#metastatic

[florida-breeze]

https://www.zazzle.com/z/drzpr9w4?rf=238911361554516080

[thisworldisrotten]

Hey does anyone have the lawlight fic Metastatic saved? I really want to read it but can't find it anywhere

[whitebelt-witch]

screamo.

[suchananewsblog]

Advanced Breast Cancer: What People Are Thinking

The day-to-day realities of navigating advanced breast cancer are challenging enough. No need to add wondering what’s going through others’ heads. But understanding your loved ones’ thought process and where they’re coming from may make it easier to talk about your condition — and get the support you need. Here, we break down some of the most common questions, reactions, and thoughts.  You look…

[chemobeanies]

Chemo Beanies has some wonderful Fall colors to choose from. Pictures here is Brooke our Rust Ruffle. #chemobeanies #chemobeauty #chemowarrior #chemotherapy #chemohair #chemohairloss #cancerhairloss #cancercare #cancercaregiver #cancerheadwear #chemoheadwrap #metastatic #hairlosssolutions #wigalternative #turban #scarf #headscarf #headwrap #turbanstyle #beanies (at Mandeville, Louisiana) https://www.instagram.com/p/CkyuCdCJ0jK/?igshid=NGJjMDIxMWI=

[kondavanelos]

Μετάσταση στο μετωπιαίο οστό.

[eureg-news]

Understanding differences between EMA and FDA positions - Different indications for OPDUALAG® in Europe and USA and the reason why:

On September 15 2022, the European Commission (EC) authorised OPDUALAG® for the treatment of melanoma with tumour cell PD-L1 expression < 1%. Remarkably, the indication (SmPC 4.1) granted by the EC based on the positive CHMP opinion of July 2022 is different from the indication granted by the US FDA.

The indication wording in Europe is: Opdualag is indicated for the first line treatment of advanced (unresectable or metastatic) melanoma in adults and adolescents 12 years and older with tumour cell PD-L1 expression <1%.

The indication wording in USA is: OPDUALAG is a combination of nivolumab, a programmed death receptor-1 (PD-1) blocking antibody, and relatlimab, a lymphocyte activation gene-3 (LAG-3) blocking antibody, indicated for the treatment of adult and pediatric patients 12 years of age or older with unresectable or metastatic melanoma.

Why this difference?

OPDUALAG® is a combination of the antibodies relatlimab and nivolumab. Nivolumab has previously been authorised for the treatment of melanoma (as OPDIVO®); relatlimab is authorised only in combination with nivolumab in OPDUALAG®. Both antibodies are checkpoint inhibitors and work as immunotherapy of cancer, with nivolumab directed against PD-1 (programmed death receptor-1) and relatlimab against LAG-3 (lymphocyte activation gene-3).

At variance with the European decision to restrict the indication to patients whose tumors have a low (<1%) PD-L1 expression, the FDA granted a broader indication without the need for a PD-L1 assay. Both indications can be justified:

Adding relatlimab to the treatment with nivolumab clearly and obviously increased PFS. In FDA’s prescribing information, the Kaplan-Meier curve clearly illustrate the superiority of OPDUALAG over nivolumab alone - obviously supporting the broader indication granted by FDA.

On the other hand, when CHMP looked at subgroups with a cut-off at 1% PD-L1, it seemed that the overall positive result is driven by the subgroup with tumour cell PD-L1 expression smaller than 1% - which is why EMA preferred the more restricted indication: OPDUALAG is indicated for the first line treatment of advanced (unresectable or metastatic) melanoma in adults and adolescents 12 years of age and older with tumour cell PD-L1 expression <1%. (https://www.ema.europa.eu/en/documents/smop-initial/chmp-summary-positive-opinion-opdualag_en.pdf)

Kaplan-Meier plot of PFS per BICR by baseline PD-L1 expression – All randomised subjects (28-Oct-2021 DBL)

Interestingly, this observation, that a second checkpoint inhibitor, which is added to nivolumab, works best in patients with low PD-L1 is not completely new. We have seen a similar subgroup effect for the combination of nivolumab (OPDIVO®) and ipilimumab (YERVOY®) we have seen a similar subgroup effect (https://www.ema.europa.eu/en/documents/product-information/opdivo-epar-product-information_en.pdf).

When the combination of nivolumab (OPDIVO®) and ipilimumab (YERVOY®) was approved for the treatment of melanoma, CHMP considered this subgroup difference important enough to justify the following addition to the indication (SmPC 4.1): Relative to nivolumab monotherapy, an increase in progression-free survival (PFS) and overall survival (OS) for the combination of nivolumab with ipilimumab is established only in patients with low tumour PD-L1 expression (see sections 4.4 and 5.1).

It looks like there’s a kind of ceiling effect for these checkpoint inhibitors, and if this ceiling has already been reached by nivolumab alone - in patients with high PD-L1 expression - another checkpoint inhibitor apparently will not add much benefit. With relatlimab, the second example after ipilimumab, for such a subgroup difference, it may seem reasonable to consider similar effects for future combinations of checkpoint inhibitors, at least with other anti-LAG-3 monoclonal antibodies, such as fianlimab. It might even be advisable to look for similar subgroup effects in trials combining other checkpoint inhibitors as well.

[marzipanandminutiae]

the fact that you can still get skin cancer even if you're diligent about sun protection (10% of skin cancers are not sun-related) is so frustrating

like yeah I'm going to keep doing it to SIGNIFICANTLY reduce my risk but! damnit I'm out here weeping over ruined printed cotton collars from my sunscreen and you're saying I'm still not 100% safe?! bullshit!

[jenthebug]

Oncologist is ditching our “wait and see” approach for something more aggro: scans, then a possible surgery to remove the breast mass and get me to No Evidence of Disease (NED). She also wants me to go to oncology rehab because she believes my fatigue is due to deconditioning.

Scans. 😒 this means a breast MRI, which are the worst.

Surgery.

NO EVIDENCE OF DISEASE.

Rehab 😒 and a possible return of all my energy.

I am having so many feelings right now it’s unreal.

I could have to have another surgery.

I could get back to almost normal. Not normal enough to dispatch again, but normal enough to be thrown back to the rat race.

But I could get back to normal enough to go hiking again, too. And keep up with my companions on vacation.

I could start making plans for the future. But I could have to start making plans for the future. I could get more years, but again, nobody knows how many.

This is a LOT and my therapist better bring her A game next time we talk, because she’s getting the dark and depressed version of this entry.

[shuttershocky]

Very fun game design to target Izumik's ending for IS3 only to have 6/7 of your operators already cursed before Floor 3 :)

[nervouswaltz]

btw as someone who lost their mother to cancer before they graduated high school if you see someone mourning the death of a loved one or friend and decide that they are a person you should make fun of i genuinely think you’re one of the most heartless beings on the planet and i hope in your time of need when you are grieving and finally understanding what it’s like and how fucking painful losing a loved one is, you get what was coming to you, and no one is there to help you through it

[holyshit]

.

[creepyscritches]

Clifton Strengths is wildly accurate but this blurb in the new report they sent me is unreal

Last year I set up a jeopardy game for a room of high level professionals and once they got their variety of buzzers (screaming chickens, kazoos, bells, etc) the room turned so silly and heehee you wouldn't believe it had you only seen the prior presentations.

Give a health care professional a rubber chicken and ask them what are the key documentation components for a psych diagnosis secondary to substance dependency and brother you're never going to cement that knowledge faster

[wolfgirlfloof]

well fuck me i guess

it's technically still a win but i haven't sated my bloodlust. i'll be back for you mr tidehunt

[chemobeanies]

When someone you care about is diagnosed with cancer, finding the right words to say can often be a challenge. Chemo Beanies make a great way to say you care without having to discuss anything. #chemo #cancer #beanies #headcoveringwomen #turbans #scarves #chemoscarf #chemoscarves #chemowraps #cancercare #cancerwarrior #chemowarrior #previvors #livestrong #metastatic #thoughtfulgift #cancergifts #chemogifts #giftshop #gifts #baldgifts #headshaved #girlswithshavedheads (at AmericasMart Atlanta) https://www.instagram.com/p/CgFTQ3JALbC/?igshid=NGJjMDIxMWI=

[thecorvidforest]

Urgent aid request from someone I know. This request is time-sensitive; if you can’t help out, reblogs/sharing the graphic elsewhere would be greatly appreciated.