#side effects of high creatinine levels

[kidneytreatment01]

Kidney Disease Remedies: Natural Approaches to Kidney Health

People suffering from chronic renal impairment require specific diet modifications to manage their condition effectively. A chronic renal failure diet typically comprises:

Limiting sodium intake can help manage blood pressure and maintain fluid balance.

The Controlled Intake of Proteins: limiting protein intake is crucial to stop the buildup of waste substances in the blood.

Potassium as well as Potassium Control: Monitoring and restricting foods high in potassium and phosphorus can assist in avoiding the complications of chronic kidney disease.

Fluid Management: Managing the intake of fluids is essential since excessive fluid could stress the kidneys.

In conclusion, kidney disease is a severe condition that can alter your life; however, natural cures and numerous kidney treatment are readily available to treat the problem. A healthy diet for kidneys, along with herbal supplements and lifestyle modifications, can be used in conjunction with medical treatments to stop the development of kidney disease and improve general well-being. If you suffer from chronic renal disease, following the proper diet is crucial in improving your health and reducing the risk of complications. Talk to kidney specialists to develop a customized treatment plan that meets your individual's specific needs and helps ensure that your kidneys are in good health.

[petfurri]

Captopril for Dogs: Benefits, Dosage, Side Effects, and More

Captopril for Dogs

Captopril is an angiotensin-converting enzyme (ACE) inhibitor commonly used in veterinary medicine to manage heart conditions in dogs, particularly congestive heart failure (CHF) and systemic hypertension (high blood pressure). Initially developed for human use, captopril has found its place in treating canine patients with cardiovascular issues, offering numerous benefits but also requiring careful administration and monitoring due to potential side effects.

Understanding Captopril and Its Mechanism of Action

Captopril works by inhibiting the angiotensin-converting enzyme, which is responsible for converting angiotensin I into angiotensin II, a potent vasoconstrictor. Angiotensin II causes blood vessels to narrow, leading to increased blood pressure and making the heart work harder. By blocking this conversion, captopril allows blood vessels to relax and widen, reducing the workload on the heart and lowering blood pressure. This action is particularly beneficial for dogs suffering from CHF, as it helps to improve blood flow and reduce fluid buildup in the lungs and other tissues.

Benefits of Captopril for Dogs

Managing Congestive Heart Failure (CHF): CHF is a common condition in dogs, especially in older or certain breeds like Cavalier King Charles Spaniels. Captopril helps manage CHF by reducing the resistance the heart faces when pumping blood, thus improving cardiac output and reducing symptoms like coughing, difficulty breathing, and lethargy.

Lowering Blood Pressure: For dogs diagnosed with systemic hypertension, captopril can effectively lower blood pressure, preventing damage to organs such as the kidneys, eyes, and brain, which can result from prolonged high blood pressure.

Improving Quality of Life: By easing the burden on the heart and lowering blood pressure, captopril can significantly improve a dog's overall quality of life. Dogs may exhibit increased energy levels, better appetite, and greater overall comfort as a result of treatment.

Potential Renal Protection: In some cases, captopril may offer renal protection by reducing the progression of kidney disease, particularly in dogs with proteinuria (protein in the urine), which is often associated with high blood pressure.

Dosage and Administration

The dosage of captopril for dogs must be carefully determined by a veterinarian, as it varies depending on the dog's weight, the severity of the condition being treated, and the presence of any other health issues. Captopril is usually administered orally, with or without food, typically two to three times a day.

Typical Dosage: The usual starting dose is around 0.5 to 2 mg per kg of body weight, given every 8 to 12 hours. The dosage may be adjusted based on the dog’s response to the medication and any side effects observed.

Monitoring: Regular monitoring is crucial when a dog is on captopril. Blood pressure, kidney function (via blood tests for creatinine and blood urea nitrogen levels), and electrolyte levels should be checked periodically to ensure the medication is working effectively without causing harm.

Potential Side Effects of Captopril

While captopril can be highly beneficial, it also carries the risk of side effects, particularly if not used correctly. Some of the potential side effects include:

Gastrointestinal Issues: Dogs may experience vomiting, diarrhea, or loss of appetite. These symptoms are usually mild but should be reported to the veterinarian if they persist.

Hypotension (Low Blood Pressure): As captopril lowers blood pressure, there is a risk that it may cause blood pressure to drop too low, leading to weakness, dizziness, or fainting. This is more likely to occur in dogs that are dehydrated or have other underlying health conditions.

Kidney Dysfunction: Captopril can affect kidney function, particularly in dogs with pre-existing kidney issues. It’s important to monitor kidney parameters closely during treatment to avoid exacerbating any renal problems.

Hyperkalemia (High Potassium Levels): Captopril can cause an increase in potassium levels, which can lead to dangerous heart rhythms if not managed properly. Regular blood tests are essential to monitor electrolyte levels.

Coughing: A persistent dry cough is a less common side effect but can occur due to the buildup of bradykinin, a substance that captopril can increase in the body.

Allergic Reactions: Though rare, some dogs may have an allergic reaction to captopril, manifesting as itching, rash, or swelling. Immediate veterinary attention is required in such cases.

Precautions and Considerations

Captopril should be used with caution in dogs with pre-existing kidney disease, dehydration, or electrolyte imbalances. It should not be used in dogs that are pregnant, as it can cause harm to the developing fetus. Additionally, it’s important to inform the veterinarian of any other medications the dog is taking, as captopril can interact with other drugs, including diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs), potentially leading to adverse effects.

[bharathomeopathy2]

Effective Kidney Failure Treatment Without Dialysis: Alternatives to Dialysis for Better Health

What are Kidney Diseases and Complications?

Kidney disorders refer to kidney conditions that impair kidney work, affecting the body’s ability to filter waste and manage liquid balance. Chronic kidney disease (CKD) is a common type that progresses slowly over time, often leading to more severe conditions like kidney failure if left untreated. Treatment for kidney failure may require dialysis or a kidney transplant, but it will be very painful; thus, many are seeking kidney failure treatment without dialysis as an alternative option.

High creatinine levels are a significant indicator of kidney dysfunction. Creatinine is a waste product produced by muscles, and the kidneys normally filter it out. High creatinine treatment is crucial in managing kidney diseases, as elevated levels may indicate the need for prompt medical intervention. Chronic kidney disease treatment typically involves medications, lifestyle changes, and dietary restrictions to slow disease progression.

Complications of kidney disease range from fluid retention to cardiovascular problems. Kidney disease can also lead to anaemia, bone disease, and neurological changes. Therefore, finding an effective cure for chronic kidney disorder is important for improving patient outcomes and quality of life.

How Do Kidney Patients Feel the Symptoms of Kidney Disease?

Symptoms of kidney disease are often subtle at first but become more pronounced as the condition worsens. Many people may not realise they have kidney disease until it has reached a more advanced stage. Early symptoms can include fatigue, swelling in the legs and ankles, and difficulty concentrating. 

As the condition progresses, patients may experience more severe symptoms, such as nausea, loss of appetite, and changes in urination patterns, such as increased frequency or blood in the urine. These signs often prompt individuals to seek kidney problem medication to manage their condition. One of the most telling symptoms is persistent high creatinine levels, which usually signals that the kidneys are not functioning optimally.

Patients with advanced kidney disease may experience more distressing symptoms, including chest pain, shortness of breath, and confusion, indicating the need for chronic kidney disease treatment. Addressing these symptoms early can help prevent the disease from advancing to kidney failure, which would then require more aggressive treatments like dialysis.

What Are the Causes of Kidney Disease?

Several factors can contribute to the development of kidney disease. The most common causes are diabetes and high blood pressure. These conditions damage the blood vessels in the renal, making it difficult for them to filter waste properly. In addition to these, chronic infections, autoimmune diseases, and genetic conditions can also lead to kidney problems.

One of the major issues in diagnosing kidney disease is that it often progresses silently, with high creatinine levels being one of the first detectable signs. This is why early high creatinine treatment is crucial. Individuals who already have risk factors like hypertension or diabetes should closely monitor their kidney health to avoid the need for more intensive treatments later on.

Infections, toxins, and certain medications can also damage the kidneys, leading to acute kidney failure. While some causes of kidney disease are beyond a patient’s control, adopting a healthy lifestyle can significantly reduce the risk of developing this disorder. If you want to stop the progression of the disease, You are suggested to adopt Treatment for kidney failure.

Is Kidney Disease a Painful Condition?

Kidney disease itself is not always painful in the early stages, but as it progresses, the discomfort can become more noticeable. Many patients report feeling fatigued and general discomfort, while some experience pain in the lower back or sides due to the buildup of waste products in the body.

In advanced stages, kidney disease can become a painful experience. Patients may feel discomfort from fluid buildup, which can lead to swelling and difficulty breathing. Some also experience severe pain as a result of complications like kidney stones or infections.

Treatments such as kidney problem medication or high creatinine treatment can help manage the condition and alleviate pain. However, when the disease reaches the stage of kidney failure, many patients may need to explore chronic kidney disease treatment options to relieve symptoms.

People seeking alternatives often look for kidney failure treatment without dialysis, aiming to reduce the pain and complications associated with traditional treatments. The good news is that ongoing research aims to discover new, less invasive ways to cure chronic kidney disease and manage symptoms more effectively.

Conclusion

Kidney diseases present a range of complications that can significantly impact the quality of life. From high creatinine levels to the need for chronic kidney disease treatment, managing the condition requires timely intervention and ongoing care. Understanding the Signs & symptoms, and causes of kidney disease is vital for early diagnosis and treatment. While kidney disease can become painful in its later stages, early cure for chronic kidney disease and lifestyle changes can slow its progression, offering hope for better management and even a cure.

[karmaayurvedichospital]

Ayurvedic Medicine to Lower Creatinine Levels Naturally

If you're struggling with high creatinine levels, Ayurvedic medicine offers a natural solution to bring them down without harmful side effects.

Problem: High Creatinine Causing Kidney Strain An increased creatinine level can strain your kidneys, leading to further health complications.

Solution: Ayurvedic Medicine to Lower Creatinine Herbal treatments like Siberian Ginseng and Gokshura have been proven to lower creatinine levels by improving kidney filtration. Combined with dietary advice, these herbs can help naturally maintain healthy kidney function.Lower Your Creatinine Levels Naturally! Get in touch for a personalized Ayurvedic consultation today. Discover more about Ayurvedic treatments.

[bharathomeopathy778]

Kidney Health: Chronic Kidney Disease Treatment Naturally-Bharat Homeopathy

About Treatment for kidney failure

Our kidneys work continuously to keep us healthy. Despite their small size, these organs play a vital role in filtering waste, regulating fluid balance and ensuring our well-being. But what happens if they start to malfunction? Illnesses such as acute kidney injury (AKI) and chronic kidney disease (CKD) can put our health at risk. Apart from abdominal pain, the patient may have to face many problems. Kidney disease should be identified and examined immediately, and if it is the initial stage of the disease, then Treatment for kidney failure should be started so that it can be prevented from becoming more serious. 

Diet for kidney Health?

If you are suffering from kidney disease and want to find a chronic kidney disease treatment very soon. So it is obvious that you need a good cure for chronic kidney diseases, but at the same time, it is essential to focus on your diet because diet for kidney patients has a great impact on the patient, and diet plays an important role in making the medicines effective. So you will need to change the way you eat. Now, you will have to make your diet routine not like that of a normal person but from the perspective of curing the disease and becoming free from this serious disease. 

We will tell you that there are many things for kidney patients that, along with foods for healthy kidneys, are very beneficial for their kidney problems. You can enjoy food items like poha, upma, porridge, sago, and plain oats.

Include low-sodium foods like ginger, carrot, and bottled gourd vegetables. Low potassium foods: parwal, tinda, capsicum, brinjal, cauliflower, cabbage. Protein-rich foods like melon seeds and watermelon seeds, as well as tur moong dal and makhana, should be in your diet. But you have to avoid cucumbers, meat, potatoes, Rice, Avocados, Tomatoes, and Whole wheat Bread.

Food & fruits for healthy kidneys

Kidneys help eliminate toxins from our bodies and maintain the levels of many minerals, such as sodium, potassium, and acids. Many fruits are very good to consume, and some are very beneficial for patients. If you want to cure for chronic kidney disease, Keeping all these things in mind, we will tell you some of the best fruits for patients with this condition.

Berries: Blueberries, strawberries, and cranberries are high in antioxidants and vitamins, promoting overall renal health.

Apples: High in fibre and anti-inflammatory compounds, apples help maintain renal health.

Fish: omega-3 fatty acids, fish like salmon and mackerel reduce inflammation and support cardiovascular health.

Watermelon and melon contain a high amount of water, which is good for urine formation.

Avoid pomegranate seeds and eat only the red part Because it puts you at risk of developing stones.

Guava also contains good amounts of potassium and phosphorus. Also, you should not eat guava seeds.

You can include peach in your diet, but diabetic patients will have to avoid it.

Having discussed various fruits and foods beneficial for kidney patients, let's now proceed further to understand the role that dry fruits play in their lives. 

Best treatment for healthy kidneys

Are you troubled by kidney problems and are looking for better kidney failure treatment without dialysis? Our Bharat homeopathic treatment of kidney is a better option for you; homeopathy treatment has many benefits, the first of which is a side-effect-free homeopathic high creatinine treatment that is completely prepared from herbs. Secondly, in the process of your treatment, our Bharat Homeopathy doctors know your complete medical history, and after that, your treatment is started, which is done keeping in mind your root causes. If you want a good body and healthy kidneys, then it is mandatory for you to adopt better treatment.

[retevmocapsule]

Retevmo: Uses, Dosage, Side Effects, Warnings

Retevmo, with its active component selpercatinib, is designed to treat adults who suffer from specific cancer conditions. These include locally advanced or metastatic non-small cell lung cancer (NSCLC) with a RET gene fusion, and locally advanced or metastatic solid tumors with a RET gene fusion. It also targets advanced or metastatic medullary thyroid cancer (MTC) with a RET mutation. The drug operates by inhibiting kinase activity, which is crucial in halting the progression of cancer cells. Additionally, Retevmo is approved for pediatric patients aged 12 and older who have advanced medullary thyroid cancer. In India, Retevmo cost in India is available at a relatively low cost and can be purchased with a valid prescription from numerous suppliers. Indian Pharma Network, known for distributing reliable generic medicines, is one of the prominent distributors of Retevmo.

rearrangement (in NSCLC or thyroid cancers). The retevmo dosage is tailored according to the patient's body weight, which is assessed before starting the treatment. Patients who weigh less than 50 kg are advised to take 120 mg, whereas those who weigh 50 kg or more should take 160 mg. This medication must be prescribed by a healthcare professional, and the treatment should be closely monitored by a qualified medical expert to ensure its effectiveness and safety.Retevmo contains the active ingredient selpercatinib, and its prescription is based on identifying a specific RET gene mutation (in the case of MTC) or a transfection gene 

Retevmo capsules should be administered orally twice daily, approximately every 12 hours, and continued until there is either disease progression or severe toxicity. The medication can be taken with or without food, except when used with a proton pump inhibitor. It's important that the capsules are swallowed whole, without crushing or chewing them. If a dose is missed, it should be taken at least six hours after the previous dose. Proper adherence to these guidelines ensures the medication's efficacy and safety.

Selpercatinib, the active ingredient in Retevmo, is a potent RET inhibitor and belongs to the tyrosine kinase inhibitor class of cancer therapies.  Retevmo 80 mg hard gelatin capsules are available for oral use. It effectively blocks the activity of abnormal proteins that are produced due to mutations in the RET gene. These proteins can cause uncontrolled cell growth and division, leading to tumor development. By inhibiting these proteins, selpercatinib reduces the growth and spread of cancer cells. Its affordability and efficacy make selpercatinib accessible to patients, offering a critical option for those battling specific types of cancer driven by RET gene mutations.

Although Retevmo is an effective cancer treatment, it can cause a range of retevmo side effects, from mild to severe. Common side effects include loss of appetite, headache, dizziness, prolonged QT interval, high blood pressure, abdominal pain, diarrhea, nausea, vomiting, constipation, dry mouth, rash, fever, fatigue, edema, and bleeding. Blood tests may show changes in liver enzymes, decreased platelet and white blood cell counts, decreased magnesium levels, and increased creatinine levels. About one in ten patients experience these side effects. The most frequently reported major adverse effects are stomach pain, hypersensitivity, diarrhea, and elevated liver enzymes, which indicate liver stress. 

[bharathomeopathytreatment]

Natural treatment for Chronic Kidney Disease and Kidney Failure Without Dialysis

Chronic kidney disease (CKD) and kidney failure are serious health conditions that often require extensive treatment. Many patients seek alternatives to dialysis, which can be demanding and have significant side effects. This article explores various non-dialysis kidney failure treatment without dialysis, including homeopathic methods, and provides insights into managing high creatinine levels and chronic kidney disease effectively.

Understanding Chronic Kidney Disease and Kidney Failure

Chronic kidney disease progresses over time and can lead to kidney failure, where the kidneys can no longer filter waste effectively. Traditional treatments often focus on managing symptoms and slowing the progression of the disease. However, some patients are exploring alternative treatments,chronic kidney disease treatment such as homeopathy, which aim to restore kidney function and improve overall health without the need for dialysis.

Non-Dialysis Treatments for Kidney Failure

Lifestyle and Dietary Changes

One of the most effective ways to manage kidney failure treatment without dialysis and prevent kidney failure is through lifestyle and dietary changes. Patients are encouraged to:

Reduce sodium intake: High sodium levels can increase blood pressure and exacerbate kidney damage.

Limit protein consumption: Reducing protein intake can decrease the kidneys' workload and slow disease progression.

Stay hydrated: Proper hydration helps the kidneys function more efficiently.

Avoid certain medications: Non-steroidal anti-inflammatory drugs (NSAIDs) can harm the kidneys and should be avoided.

High Creatinine Treatment

High creatinine levels are a marker of kidney dysfunction.High creatinine treatment is crucial for patients with CKD. Several natural methods can help lower creatinine levels:

Herbal remedies: Herbs like nettle leaf, dandelion root, and ginseng are believed to support kidney health.

Acupuncture: Some studies suggest that acupuncture can help improve kidney function and reduce creatinine levels.

Dietary adjustments: Eating a diet rich in antioxidants, low in potassium, and balanced in protein can help manage creatinine levels.

Homeopathic Treatment for Kidney Failure

Homeopathy offers a holistic approach to treating kidney failure, focusing on the body's ability to heal itself. Homeopathic medicine for high creatinine and treatment for kidney failure involves the use of natural substances in highly diluted forms to stimulate the body's healing processes. 

Kidney Treatment by Homeopathy

Homeopathic treatment for kidney failure are tailored to the individual, considering their specific symptoms and overall health. Practitioners may recommend lifestyle changes, dietary adjustments, and specific remedies to support kidney function. It's important for patients to work with a qualified homeopath to develop a personalized treatment plan.

Integrative Approaches

Combining traditional medical treatments with alternative therapies can offer a comprehensive approach to managing CKD and kidney failure. Integrative treatments may include:

Nutritional therapy: Working with a dietitian to create a kidney-friendly diet.

Physical activity: Regular exercise can help improve overall health and support kidney function.

Stress management: Techniques like meditation, yoga, and breathing exercises can reduce stress, which can negatively impact kidney health.

Conclusion

Chronic kidney disease and kidney failure are serious conditions that require careful management. While dialysis is a common treatment, many patients are exploring alternative options to improve their quality of life. Non-dialysis treatments, including lifestyle changes, dietary adjustments,kidney treatment by homeopathy, offer promising results for some individuals. By working closely with healthcare professionals and considering integrative approaches, patients can find effective strategies to manage their condition and potentially avoid dialysis.

[drnishagaur123]

Symptoms, stages, and treatment of chronic kidney disease (CKD)

What is Chronic kidney disease?

The main function of the kidney is to filter blood and chronic kidney disease means the kidneys are impaired and can’t able to filter the blood as per expectations. There are many reasons behind developing kidney diseases like high blood pressure, diabetes, and heart disease sometimes it is genetic and may depend upon the family’s health history. Only health practitioners can evaluate how a patient develops chronic kidney disease by doing certain tests.

Facts about Human kidneys

• Human kidneys are as small as a mouse or a computer.

• It filters all the blood of the body every 30 minutes.

• Our kidneys work hard to remove toxins, wastes, and excess fluid.

• Our kidneys facilitate the production of red blood cells.

• They handle blood chemicals that are important for human life.

• They keep all the bones healthy.

How to recognize chronic kidney disease?

The only way to find out what’s wrong with the functioning of the kidney of the patient is through tests. Your practitioner will do certain tests and can only identify the cause after going over the reports of that tests.

You have to get checked your diabetes level, blood pressure, and heart health because these are the main reasons behind chronic kidney disease. The reason behind finding out the cause of CKD is it affects the treatment a patient will be going to receive for CKD.

There are two types of tests mainly done for identifying Chronic kidney disease

• Urine test:- That checks the amount of protein in the urine which is also an early sign of a kidney issue.

• Blood tests:- These checks the creatinine level in the blood which is a waste product.

Symptoms and side effects of Chronic kidney disease include

• Anemia or low blood cells.

• It increases the chances of infections in the body.

• Loss of appetite.

• Weakness and dizziness.

• Depression affects the quality of life.

• Low calcium levels in the blood.

• Changes in the pattern of urination

• Edema or swelling of limbs.

• Shortness of breath.

• Irregular heartbeats.

• Secretion of blood in the urine.

• Skin itching.

• Muscle cramping.

Stages of Chronic kidney disease

There are mainly 5 stages of Chronic kidney disease and depends upon the eGRF which is the estimated glomerular filtration rate that shows how well your kidneys are filtering the blood and other waste products.

STAGE 1

This means – impairment in the kidney but still functions normally.

Signs and symptoms –

• High blood pressure.

• Urinary tract infection.

• Edema.

• Abnormal urination.

• Fatigue. 

STAGE 2

Signs and symptoms –

• High blood pressure.

• High diabetes level.

• Changes in the color of urine.

• Swelling in hands and legs.

• Dizziness.

STAGE 3

This means – Impairment of kidneys with mild to moderate loss of functioning.

Signs and symptoms –

• Changes in urination

• Fluid retention

•  high blood pressure

• Low Red blood cells.

• Loss of appetite.

STAGE 4

This means – Severe loss of functioning of both kidneys.

Signs and symptoms –

• Anemia

• Bone disease

• Loss of appetite.

• Abnormal calcium levels in the blood.

• Abnormal phosphorus levels in the blood.

• Dizziness.

STAGE 5

This means – close to failure, loss of all the Kidney Biopsy or failure of one of both kidneys.

Signs and symptoms –

• Fatigue.

• nausea.

• Vomiting.

• Shortness of breath.

• Loss of appetite.

• Anemia.

• Swelling in hands, legs, and back.

• Back pain. 

Treatment of Chronic kidney disease

Treatment of CKD involves:-

• MEDICATION

• MEDICAL PROCEDURE – DIALYSIS

•  SURGERY OR KIDNEY TRANSPLANT

• SELF CARE

Treatment of chronic kidney disease

• High blood pressure medication

Generally, people with CKD have higher blood pressure. So,  doctors prescribe medicines that lower the blood pressure and reduce the kidney functioning this may require frequent blood tests. Normally, angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers are prescribed by doctors to maintain normal kidney function.

• Fluid retention

Patients with CKD generally suffer from edema (swelling in hands and legs) or water retention to treat edema doctors prescribe diuretics that help maintain the fluid balance in the body.

• Medications to treat anemia

Supplements of the hormone erythropoietin sometimes with added iron, help stimulate more red blood cells and decreases the weakness, fatigue, and dizziness related to anemia (lower HB levels).

• Medications for phosphate balance

Normally phosphate binders are given to maintain the phosphate balance in the body.

Drugs given for phosphate binders are

• Sevelamer carbonate at 800 mg dose (6–12capsules)

• Lanthanum carbonate 250–1000 dose (3–6 chewable tablets)

• Bixalomer at 250 mg dose (6–12 capsules)

• Ferric citrate at 210 mg dose (3–5 tablets)

is generally prescribed by doctors. 

• Skin itching

Commonly calamine and menthol are the two cooling agents which are given in the form of a lotion to reduce itching caused by chronic kidney disease. Doctors also recommend ice packs and oatmeal baths to treat the itching.

• Dialysis

Dialysis involves the removal of waste products and excess fluid artificially either by a dialysis machine or outer filters.

In hemodialysis, a machine filters all the blood and waste products from the body.

Whereas in peritoneal dialysis a thin tube is inserted in the abdomen cavity of the patient with the dialysis solution that absorbs excess fluid and removes the waste from the body. 

• Surgery or Kidney transplant

The process of placing healthy kidneys taken by the donor into the patient’s body is known as a kidney transplant or surgical procedure for the fifth stage of chronic kidney disease. The kidneys either came from a deceased person or a healthy living donor. You have to take lifelong medications to maintain the acceptance of new organs by your body and will not need any dialysis after that.

Conclusion

Chronic kidney disease is a serious illness if you keep ignoring the symptoms it even worsens with time if left untreated,  so it is important to talk to the general health practitioner The more you delayed the more it became difficult to treat chronic kidney disease stages.   If you are facing severe Most Common Kidney Diseases, then you should consult Dr. Nisha Gaur. Dr. Nisha Gaur is the most reputed Nephrologist doctor in Jaipur and has years of work experience and is the Best Nephrologist in Jaipur for Chronic Kidney Disease Care and also for treating ailments such as Kidney Transplantation, Peritoneal Dialysis, Hemodialysis, and Kidney Biopsy.

[dranirudh-1234]

Kidney transplant in Pune

A kidney transplant is a surgical procedure where a healthy kidney from a donor is transplanted into a recipient who has a damaged or failed kidney. The procedure is performed when the patient's kidneys are no longer able to function properly due to chronic kidney disease, acute kidney injury, or other medical conditions.

Before the transplant, the patient undergoes a series of medical tests to determine their overall health, the type of kidney they need, and whether they are a suitable candidate for the procedure. The donor can be a living donor, usually a family member or a friend, or a deceased donor whose kidney has been donated after their death.

Blood filtration, blood pressure control, and haemoglobin levels are just a few of the vital functions carried out by our kidneys. Chronic Kidney Disease (CKD), another name for kidney failure, denotes chronic and irreversible kidney damage that is permanent. All of the kidneys' functions are compromised by this illness. This worsens blood pressure, anaemia, and bone disease while also causing more kidney damage.

Which factors contribute most to kidney failure?

There are various explanations for why renal failure happens. These danger variables are:

1. Diabetes: Diabetes is the main risk factor for CKD. In this situation, diabetes is discovered in its later stages, by which time other organs like the kidneys would have been impacted, due to a lack of awareness and a proactive approach regarding routine health checks.

2. Hypertension: When left untreated, hypertension poses a very significant risk of renal failure. On the other hand, hypertension is not a significant risk factor when it is under control.

3.Family History: Having chronic kidney disease raises the likelihood of contracting renal failure from a family member.

4.Infections: Repeated kidney or urine infections are further warning signs of this condition.

5. OTC drugs: Taking tablets without the guidance of a trained medical professional can have disastrous consequences on the kidneys as well as numerous other negative side effects.

6.Glomerular disease: The presence of proteins in the urine is an early warning indication of kidney damage and, if left untreated and undiscovered, kidney failure.

What are the indications that your kidneys may be in trouble?

The typical warning signs and symptoms are:

1. Undiagnosed anaemia

2.Weakness

3.Tiredness

4. Issues with sleeping

5. Chest ache

6. Breathing difficulty

7. Appetite loss

alterations in urine

9. Facial and foot swelling

10. Constant nausea

11. Reflux

12. Unaccounted-for weight loss

By the time the patient experiences symptoms and seeks medical attention, the kidney has typically already suffered serious damage. This is the rationale behind not waiting for symptoms to show before having your kidneys examined.

How can renal failure be identified early?

To stop this disease from progressing further, it is essential to have a diagnosis early on before it aggravates. The diagnostic methods comprise:

1. Blood tests: to determine the quantity and concentration of chemicals like urea and creatinine.

2. Urine tests are done to assess the amounts of albumin, creatinine, and blood proteins in the urine to see how effectively the kidneys are working.

3. Imaging tests: CT, MRI, and ultrasound scans can help provide an image of the kidneys and aid in the search for any blockages or anomalies.

4.Biopsy: A little kidney sample is taken, and it is examine

7 Absurdly Efficient Ways to Maintain Healthy Kidneys

What options are there for treating kidney failure?

The stage of the disease determines the course of treatment for CKD.

1. The first three phases of kidney failure are those of early onset, during which the underlying cause must be addressed but no special medications for renal failure are given. For instance, blood sugar levels need to be controlled if a person has diabetes. The same holds true with high blood pressure.

2. Giving up smoking is a crucial first step. The earliest possible investigation must be made into any kidney or urine infections.

3. Kidney function may be impaired by up to 60–70% in the latter stages. In these situations, blood pressure regulation and avoiding kidney-harming substances should be prioritised.

4.Some drugs have been shown to stop further advancement, including angiostein-converting enzyme (ACE) inhibitors and angiostein receptor blockers.

5.Medications are ineffective in stage 5, where kidney loss has reached 80–90%, and the only options are dialysis or, if the patient is healthy enough, a kidney transplant.

6. Exercise can indirectly benefit CKD patients since it helps maintain healthy blood pressure, sugar levels, and weight, all of which slow the disease's progression. moderate workouts, such as

7. As kidney disease progresses past stage 4, the possibility of renal failure increases, and it must be managed with particular drugs and dietary modifications like reducing salt and fluid intake as well as looking for any indicators of cardiac problems. Dialysis and kidney transplantation are the only available treatments for kidney failure.

[kidneytreatment01]

Journey to Renal Health: Living with Chronic Kidney Disease

Understanding Acute Kidney Injury (AKI) and Taking Care of It

Kidney health is crucial for overall health and well-being, and knowing the signs that indicate kidney issues is essential to avoid severe complications. Chronic kidney condition (CKD) or acute kidney injury (AKI) can cause kidney failure if untreated. The recognition of signs of kidney failure and having regular kidney function tests could help in the management of these conditions.

Journey to Renal Health: Living with Chronic Kidney Disease

Chronic kidney disease can be a chronic condition that develops slowly as time passes. The condition is usually only recognized in its final phases, so people must acknowledge typical signs of kidney failure. Early indicators of CKD are fatigue, trouble concentrating, and frequent urine leaks. As the disease progresses, more severe symptoms, like blood in urine, swelling in the legs and ankles, and elevated blood pressure, could be seen.

To detect CKD and track its progress, kidney function tests are vital. The most frequently used difficulty is determining the glomerular filtration rate (eGFR), which measures the kidneys' efficiency in removing blood-borne toxins. A blood test to check the creatinine level, an irritant from the metabolism of muscles, is an element of the diagnosis process. A decrease in eGFR or elevated creatinine levels could indicate chronic kidney disease.

Your Kidney Specialist: The Knowledge of a Renal Physician

Patients who suspect that they may have kidney issues or the risk factors for CKD, like the presence of diabetes or high blood pressure, should seek out a kidney specialist. Nephrologists are medical specialists who specialize in diagnosing and treating kidney problems. They can provide essential insights into the kidney's function and design an individual treatment plan that can reduce the progress of CKD and avoid kidney failure.

Alongside CKD, acute kidney injury is a severe separate problem that requires immediate care. Contrary to CKD, AKI is a rapid decline in kidney function, usually due to severe infections, dehydration, or toxic effects from drugs. Common kidney failure symptoms associated with AKI include decreased urine output and nausea, swelling, and confusion. It is essential to act quickly to stop further damage to the kidneys.

Recognising the Signs and Treatments of Kidney Failure

Kidney specialists play a crucial part in diagnosing or treating acute kidney injury. They utilize a variety of tests to identify the root cause, including urine and blood examinations, scans of the imaging as well as kidney biopsy. Recognizing the root of the issue is crucial for successful kidney treatment.

For CKD and AKI situations, therapy can include lifestyle changes and medications. Early detection by kidney function tests dramatically improves the likelihood of a good outcome and the quality of life of those affected by kidney disease.

Prevention of kidney problems is equally vital. Being healthy, managing chronic diseases such as hypertension and diabetes, and maintaining a healthy diet are crucial to ensure the health of kidneys. Regular visits to a healthcare doctor can help people monitor your kidney's function and spot possible issues before they become serious.

[bharathomeopathy2]

Kidney Failure Treatment Without Dialysis: Alternative Medication for Chronic Kidney Disease Treatment

What is kidney disease? 

Kidney disease, especially chronic kidney disease (CKD) can be a very serious health condition in which the kidneys slowly cease to remove the excess fluids and waste from the blood. The condition can cause an unintentional accumulation of wastes within the body, which can cause numerous health problems. Kidney diseases can lead to kidney failure, called end-stage renal disease in which the kidneys can no longer function as they should. If you don't get timely and effective Treatment for kidney failure, kidney disease could cause life-threatening complications.

Understanding Kidney Disease 

The kidneys are vital organs for filtering fluids, maintaining electrolytes in balance and ensuring overall fluid balance. Kidney diseases can be classified into two major kinds:

Acute Kidney Injury (AKI): This is an abrupt decrease in kidney function that may be reversed with the right treatment.

Chronic Kidney Disease (CKD): A gradual decline in kidney function with time, usually leading to kidney disease.

CKD is more prevalent and is usually caused by conditions like diabetes or high blood pressure as well as glomerulonephritis (inflammation of the kidney's filtering unit). Other causes include genetic diseases, long-term incontinence of the urinary tract and chronic kidney infections.

Complications of Kidney Disease

The High Blood Pressure Kidneys damaged are less capable of regulating blood pressure, resulting in hypertension. This is then able to further harm the kidneys, resulting in an unending cycle.

Anemia: Kidneys that are healthy make the hormone erythropoietin that stimulates the production of red blood cells. The damage to kidneys can lower the amount of erythropoietin in the body, causing anaemia.

Bone Disease: Kidneys assist to regulate phosphate and calcium levels. In CKD the balance is disturbed, resulting in bones that are weak and an increased possibility of fractures.

Fluid Retention: Kidneys that are failing cannot eliminate excess fluid from the body, which causes swelling of the ankles, legs, and hands, and shortness of breath as a result of accumulation of liquid in the lungs.

The high Creatinine Levels: it's a waste product that is removed through the kidneys. Creatinine levels that are high in the blood signify decreased kidney function. They are also utilized as a way to determine the degree in kidney diseases.

Kidney Failure: One of the most serious consequences that can occur with CKD is kidney dysfunction, in which the kidneys lose their capacity to function. The stage of kidney failure is a need for immediate treatment, usually with dialysis or a kidney transplant.

Homeopathy for Kidney Disease

Homeopathy cure for chronic kidney disease is a holistic and natural type of medicine that is an alternative or an alternative strategy to treat kidney disease. The treatment aims to increase the body's ability to heal itself and restore balance without harsh medications or harmful procedures.

Homeopathic Approach to Kidney Disease:

A Personalized Treatment Approach: Homeopathy emphasises personalised treatment based upon the patient's specific symptoms, medical history and general health. A doctor of homeopathy will take into consideration the emotional, physical and mental health of the patient prior to making a recommendation for a remedy.

Natural Remedies Homeopathic remedies originate from natural substances, such as minerals, plants, as well as animals. The remedies are prepared in highly dilute forms, which makes them safe and free of adverse side effects.

The root cause of the problem instead of merely treating symptoms, homeopathy seeks to treat the underlying cause that causes kidney problems. For instance, in the case of CKD caused by diabetes or high blood pressure, homeopathic treatment focuses on controlling these conditions to avoid further damage to the kidneys.

Enhancing Kidney Function Improve Kidney Function: Homeopathic remedies are commonly utilised to improve kidney function and lessen inflammation. These remedies aid in eliminating toxic substances, ease pain and enhance urinary function.

Lowering the Creatinine Levels of High-Creatinine Patients: Homeopathic remedies that are specific to the patient are believed to lower the levels of high creatinine by improving kidney function and aiding in detoxification.

Preventing Kidney Failure with Homeopathy is a method to slow the development of CKD and to prevent kidney damage by helping to support the kidneys' capacity to regenerate and heal. 

The Role of Homeopathy in Chronic Kidney Disease Treatment

Homeopathy can be extremely beneficial as a complement to chronic kidney disease treatment in conjunction with conventional therapies. It may help alleviate symptoms, lessen the need for dialysis, and improve patients' quality of life.

Advantages of Homeopathy in CKD Treatment:

Safe and non-invasive Homeopathic medicines are not invasive and are free of negative side effects, which makes them an ideal choice for long-term usage.

Holistic Methodology: Homeopathy treats the patient in a holistic way, taking care of the physical, emotional and psychological aspects that are essential in chronic diseases such as CKD.

Preventing Kidney Failure By controlling the underlying factors that cause kidney problems homeopathy may be able to stop or delay the development of kidney failure.

Kidney failure treatment without dialysis for patients looking for alternatives to dialysis homeopathy may be the best option, as it aims to enhance renal function in a natural way.

Conclusion

Kidney problems are a serious issue that requires careful treatment to avoid complications, such as high levels of creatinine as well as cardiovascular diseases, as well as kidney disease. While conventional treatment is essential, homeopathy provides a holistic natural method for high creatinine treatment, which focuses on addressing the root of the issue and assisting your body's process of healing. Through the integration of homeopathy into a treatment regimen, patients can benefit from an improvement in kidney function, better treatment of their symptoms, and even be able to avoid dialysis.

[bloodredx]

Day 4: Medicine

It had been centuries since she first took up the practice, and if anyone knew the truth, one might argue that Lady Serena had invented the concept of modern medicine in Glacidea. She of course, would deny that if pressed, but fortunately no one would know to bring up the claim in the first place. One would just need to take one look around her office’s “collection of antique medical equipment” to see how things have changed over the years. Of course, these were really just a collection of favorite tools she herself used, some more delicate than others. Still, even knowing the good memories of helping people, saving lives, and removing pain from those who so desperately needed the care, the lingering knowledge of death would forever chase her.

Perhaps when she was younger, and felt more guilt over her position in unlife, particularly over the damage she had past caused, that death’s hand being right next to her own would have made her quiver. No longer, for Serena was now quite confident with the fact that Adamsa Frisay often accompanied her on her lonely walks down the hospital’s hallways. The God of the End was the most mysterious of the pantheon, but that never changed the sad kinship she felt when reflecting upon that inevitability, even for herself. Though she’d been plenty successful in not meeting him just yet.

Still, she was no god. And no matter what, people died. Her eyes scanned the test results quickly, keeping pace with the strip of paper the blood chemistry machine was printing out. “Lymphocytes dangerously low…” The doctor pulled up her patient’s chart as she remained unsurprised. His blood smelled that way, even as she loaded it into the machine. “Ketone high as well. Just into the brink of acidosis.”

The Lady took a sip from a coffee mug, cheekily printed with a label to “Donate Blood!” Of course the substance within was the result of such generosity, but the taste of good blood still didn’t overpower the smell of her patient’s blood. “Creatinine is also sky rocketing.” She tutted her tongue as she made notes in her precise cursive.

Icarus, who never felt truly comfortable in the lab, seemed able to put aside his general discomfort for once to take interest in his mentor’s work for once. “Do you always talk to yourself this much while working?”

Serena shot him a look with targeted precision. “Does it bother you?”

Her ward nearly recoiled, lifting his hands in defense. “Not at all. I meant to ask, does it help you?”

“Organize my thoughts, yes. I suppose it’s more routine at this point.” She laid her pen down on the counter, and pulled the read out of results from the printer. Another sip of her mug as she crinkled her nose. “Does the smell not bother you?”

“Of that man’s blood?” Icarus raised his brow. “A little, now that you mention it. But it’s still so intoxicating in any other way.”

“Hmm.” Serena noted his response before turning to face him, a stern expression on her face.

“What’s wrong with him?”

“He’s dying.” She took another measured sip of blood. “Critical failure of his kidneys and liver to an extent that he would not survive the wait list for a transplant. For either organ.”

Though it had been years that he’d known the Lady now, her bluntness never sat easy with him. Even more so at the weight for a potential death. “Anything you can do?”

“An ignorant question.” She concluded quickly. “There is much we can attempt, dialysis, intense regiments of drugs that would otherwise cause innumerable side effects to his overall quality of life. But the fact remains he was rolled into my ER unconscious and so affected by jaundice that even running these tests for a few minutes has cut off the effectiveness of any treatment by hours. Days even.”

“So you’ll let him die?” Icarus stood up, feeling heat coursing through his veins. Though he wasn’t sure what the cause was, certainly the Lady could be cruel, but she wasn’t heartless. At least not to that extent.

“Everyone dies, Icarus. Even us.” Her voice was icy, flat against the sterile lab environment. “But that being said, I have ideas of options for his family. Ultimately, that’s their choice, his fate. And you had best believe I’ll go through with any plan they approve to my best ability. I’ll move mountains, drain seas, and plug volcanos for them. But I am merely a medical tool, I can no better stop the inevitable than you can stop time eroding history.”

A silent standoff went off within Icarus’s mind. She was right on one level. But she did have other choices. One that most other doctors didn’t. “Have you ever thought about embracing someone?”

He regretted the question the second it left his lips, wincing reflexively to avoid the sour expression and lecture his mentor was sure about to bury him under. But after a few moments of extended quiet, he cracked an eyelid to see what stopped her from her relentless fury.

Instead of the traditional scowl, her face was heavy with an emotion he hadn’t seen on Serena. Was it sadness? Remorse? He couldn’t tell, but her lips frowned in a softer angle than he had seen before, and for once she had broken her near constant, near dominating eye contact. No, she was staring squarely at her own wrists, eyes following the too dark veins that crossed under her pale skin. She a drew a deep breath, one that both of them knew was unneeded, but still an element to any conversation, no matter the need of oxygen, before opening her mouth slowly to speak.

“I would love to lie to you and say no, it hasn’t.” A pause, unlike her. “But I am many things, a liar is not included amongst them.” A finger traced alongside the veins as she continued. “It would be very easy, the most perfect cure to illness, and a near perfect one to death entirely. And though I am quite content with my existence, I cannot find nor guarantee that anyone else would be. To be thrust upon bloodlust without even knowing it, to be so sick and nearly gone to meet the gods again, and then be thrown back to the world with such darkness taken within them. I cannot ordain such behavior.

“There was an opportunity long ago where I could have done so to save someone I loved above all else at the time, to change the entire history of my world. But I wouldn’t, no, couldn’t do it. And the world has never been the same for me since.” She stepped away from the counter, taking a few stride to where Icarus was sitting, all in order to place a calm hand on his shoulder. “I cannot ask someone to follow me to where I am, but I have thought of it. It’s almost a feature of the blood; that we make more of ourselves to survive. However, I only ask that if you come upon the chance to find yourself in my shoes, that you won’t fall back to the easy fix, the snake oil cure. Vampire blood does much, but it takes much more than it gives. Practice good medicine in all that you do. I would hope I’ve rubbed off enough on you to leave you with that guidance if nothing else.”

Icarus felt himself frown as he tracked the glow of light in her brown eyes. What could he say in response to that? Certainly nothing snippy as he normally would, no. Heaviness sat in the air a moment, lingering like cigar smoke before he broke her gaze. “Of course, Lady Serena. I won’t do anything to disappoint you.”

Her hand dropped down to his, lifting them to chest level as she squeezed them tightly. “I know you won’t.”

The tenderness struck him, but then again so did everything else about this exchange. And he knew a little bit better the exact person his mentor was. While he could do little in the nature of medicine that she could, he could at the very least go on with the same grip on existence. “You have a life to fight for.” He returned the squeeze to her hand before letting go with a little push.

Her normal features snapped back into place, resetting the scene as if it had never happened in the first place. “That I do. Please excuse me.”

(OC-tober challenge by @oc-growth-and-development can be found here)

[bharathomeopathy778]

Kidney Failure Treatment without Dialysis: Natural Treatment Strategies

About Kidney Diseases

Chronic kidney disease (CKD) is a severe condition symptomized by a gradual loss of renal function with time. Traditional chronic kidney disease treatment often focuses on managing disease-related symptoms and slowing disease progression, but many people are turning to homeopathy for its comprehensive approach to health. In this article, we'll delve into the benefits of homeopathy treatment for kidney failure, explore the impact of high creatinine levels, and discuss available treatment options.

Homeopathy and Chronic Kidney Disease

Homeopathy is a system of alternative schools of medicine based on the treatment principle of "like cures like." This means that natural substances that cause disease symptoms in a healthy individual can, in diluted form, treat those same symptoms in a sick person. In order to provide a cure for chronic kidney disease, homeopathy aims to address not just the disease-related symptoms but the overall well-being of the patient, focusing on individual symptoms and underlying causes.

Homeopathy Treatment Benefits for Chronic Kidney Disease

Personalized Approach: One of the major benefits of homeopathy is its personalized treatment plan. Homeopathic practitioners conduct a thorough assessment of the patient's physical, emotional, and psychological state to prescribe a remedy tailored to their specific needs. This individualized approach can help manage CKD symptoms more effectively than a one-size-fits-all solution.

Minimal Side Effects: Homeopathic remedies are prepared in highly diluted forms, which typically results in fewer side effects compared to conventional medications. This is particularly advantageous for CKD patients, who may already be on various kidney problem medication and want to avoid additional drug interactions or adverse effects.

Supportive Care: Homeopathy not only targets kidney-related symptoms but also provides supportive care for associated conditions such as hypertension or diabetes, which often accompany CKD. By improving overall health, homeopathy can potentially slow disease progression and enhance quality of life.

Holistic Healing: Homeopathy treats the person as a whole rather than focusing solely on the disease. This holistic approach can address lifestyle factors, emotional stress, and other contributing elements, fostering overall well-being and potentially improving kidney function.

High Creatinine Levels and Chronic Kidney Disease

Creatinine is a waste product created from muscle metabolism and normally filtered out by the kidneys. High creatinine levels in the blood are a common marker of kidney dysfunction and can indicate worsening chronic kidney disease.

Effects of High Creatinine on Chronic Kidney Disease

Progressive Kidney Damage: High creatinine levels reflect impaired kidney function. If left unchecked, elevated creatinine can signal the progression of CKD, leading to further deterioration of kidney function and eventually kidney failure.

Symptoms and Complications: Increased creatinine levels can lead to symptoms such as fatigue, nausea, and swelling. Over time, high creatinine can cause complications like electrolyte imbalances and fluid overload, which exacerbate CKD and impact overall health.

Treatment Necessity: Managing high creatinine levels is crucial in CKD treatment. Effective management can slow disease progression and prevent complications. Both conventional and alternative treatment options, such as homeopathy, play a role in addressing these elevated levels.

High Creatinine Treatment Options

Conventional Treatments: Traditional approaches to managing high creatinine levels include medications to control underlying conditions like hypertension and diabetes, dietary modifications, and lifestyle changes. In severe cases, dialysis or kidney transplantation might be necessary.

Homeopathic Remedies: Homeopathy offers several remedies that can help manage symptoms associated with high creatinine levels. For example, certain remedies are sometimes used to support kidney function and reduce symptoms related to high creatinine. However, it's essential to consult with a qualified kidney specialist to determine the most appropriate remedy based on individual symptoms and health conditions.

Cure for Chronic Kidney Disease

The focus of homeopathic kidney failure treatment without dialysis is on managing disease-related symptoms, slowing progression, and improving quality of life. While homeopathy and other alternative treatments can play a significant role, they should be used in conjunction with conventional medical care.

Homeopathy as a Complementary Approach

Homeopathy is best viewed as a complementary treatment rather than a cure. It can support conventional treatments by addressing individual symptoms, improving overall health, and managing side effects. Integrating homeopathy with standard medical care can provide a comprehensive approach to CKD management.

Conclusion

In conclusion, homeopathy offers a comprehensive approach to managing chronic kidney disease, focusing on individualized care and minimal side effects. It can provide significant benefits in managing symptoms and improving quality of life. High creatinine levels, a marker of kidney dysfunction, require careful management through both conventional and complementary high creatinine treatment. Exploring homeopathy as part of a comprehensive treatment regimen can be a valuable addition to traditional approaches, supporting overall health & well-being. Always consult with homeopathic healthcare professionals to create a balanced and effective treatment strategy tailored to your specific needs.

[vulnera-sanentura]

Next in the Cat Series: Hyperthyroidism!

One of my favorite cat diseases, because unlike other chronic health issues, it’s not only easy to diagnose, but curable too! (phew, not all of them are just supportive care)

Who gets it? The typical hyperthyroid cat is older (mean age of 13 years), with females being predisposed and with no breed predilection beyond “mixed breed.” It can be diagnosed in cats from 4 to 22 years old, though it’s very uncommon to see it in cats younger than 8 years.

What’s it look like? These cats are usually thin or losing weight, despite a ravenous appetite (polyphagic). They can also be PU/PD (polyuric/polyphagic, ei, they drink and pee waaay more than is normal). They can become more active, literally putting the hyper in hyperthyroid, or more aggressive than they used to be. Other signs that aren’t very specific to hyperthyroidism are vomiting and diarrhea.

So what is it? Hyperthyroidism is a condition where a tumor in the thyroid gland, located in the neck on each side of the trachea, causes excess production of thyroid hormones, especially notable is T4. Thyroid hormone is responsible for a variety of metabolic functions, and this increase in metabolism is what causes many of the presenting signs: hyperactivity, weight loss despite appetite, aggression.

How do you diagnose it? The most definitive diagnosis of hyperthyroidism is through checking blood concentrations of T4. It’s increased? Congrats, you’ve diagnosed hyperthyroidism! Though a lot of feline specialty practices have it always on the normal blood chemistry, it may be an add-on at other general practices, and that’s when it may get a bit trickier to diagnose originally.

The history should help clue you in a lot, but on physical exam you’ll also potentially see:

Thin/decreased weight from last visit

Dehydration

A palpable “thyroid slip” - the thyroid gets large enough you can feel it when you run your fingers along the side of the trachea. Not all hyperthyroid cats have it, and it can be hard to get used to finding the slip

Poor hair coat

Cardiac abnormalities: tachycardia (>220 bpm), murmur, arrhythmias, a gallop rhythm

Hypertension, which can cause ocular or neurologic issues

Besides increased T4 on bloodwork, you may also see an increased ALT and/or ALP, sometimes insanely high while all the other liver enzyme values are normal. A fifth will also have azotemia (increased BUN), either due to dehydration or concurrent renal disease.

And since they’re older cats, there may be other chronic illnesses like CKD, diabetes, or GI disease.

You said this one’s not just treatable, but curable?? Yes! The treatment of choice is radioactive iodine therapy. Iodine is taken up by the thyroids to create thyroid hormone, so once the radioactive iodine is injected it’s selectively picked up by the thyroid. And since the tumor cells are working overtime, the radioactive iodine (I-131) is picked up by the tumor cells, killing them, and leaving the currently-dormant normal thyroid cells intact.

Pros:

It works rapidly (improvement within 2 weeks, back to full normal in 3 months)

Very effective, with an over 90% cure rate

No pills in angry old cats

Permanent, one time correction

Cons:

Expensive, usually costing over $1000 (~1400)

Requires special facilities, so it’s not available everywhere

Using radioactive materials, so requires containment of your cat at the hospital from anywhere from 2 days to 2 weeks, and usually the shorter time periods require special at home distancing from your cat

May need retreatment if it’s a thyroid carcinoma (2% of cases), so more $$$

What if I can’t afford that? Any other options? Yep, there’s methimazole, which come in a pill form or a transdermal cream. It works by blocking thyroid hormone synthesis, so while it doesn’t cure hyperthyroidism, it will lower T4 levels and mitigate clinical signs.

Pros:

Not as expensive up front, though can cost more over the course of the disease

No hospitalization

Available anywhere cats are seen

Cons:

Pilling angry cats sucks, some don’t like the cream either

Twice daily, nonpermanent medication

Manages, doesn’t treat the disease. The thyroid tumor can grow, requiring more medication, or transform into a carcinoma instead of a benign tumor

Side effects! - GI upset, neutropenia/thrombocytopenia, GI upset (pill), and the worst: facial excoriation, where the cats’ faces are so itchy they scratch off their skin. Reversible with discontinuation.

There’s also surgical removal of the thyroids, which has fallen out of favor, and Hill’s Y/D hyperthyroidism food, which is iodine restricted and not highly recommended by endocrinologists.

I’ve heard hyperthyroid treatment causes renal disease, is that true? No, but it often unmasks kidney disease. These two diseases, hyperthyroidism and CKD, have a very common demographic in older cats. Hyperthyroidism can increase the filtration rate of the kidneys, which makes the bloodwork levels, BUN and creatinine, that we use to diagnose CKD, decrease. Once the hyperthyroidism is cured, the filtration rate decreases, and those values jump up.

If the kidneys already look bad before treatment, the vet may want to do a “methimazole trial” before committing to radioiodine. This will allow the T4 to drop and uncover the true extent of renal disease, and since methimazole isn’t permanent it can be discontinued if the renal disease is too bad.

Most feline specialists still recommend treating the hyperthyroidism even if there is severe underlying kidney disease, but this can help us prepare for what to expect after radioiodine.

What’s the prognosis, almost-doc? Well, it depends. These cats are already fairly old, so part of the shorter lifespan can be due to other concurrent old age changes/diseases. If properly managed, the median survival time is 2-4 years, though if cured with iodine at 10 years old they could truly live into their 20s. I heard of a cat treated with radioiodine in their 20s and is now in their 30s!

[retevmocapsule]

Retevmo: Empowering Patients, Transforming Lives"

Retevmo: Indication and Usage

Selpercatinib is the active medicinal ingredient of the cancer treatment Retevmo. It is used to treat patients who have one of the following conditions:

Locally advanced or metastatic non-small cell lung cancer with a RET gene fusion

Locally advanced or metastatic solid tumours with a RET gene fusion

Advanced or metastatic medullary thyroid cancer (MTC) with a RET mutation It demonstrates its action by inhibiting kinase. It is also utilised in pediatric patients older than 12 years with advanced medullary thyroid carcinoma. Retevmo capsule price in India is reasonable and can be obtained with a valid prescription, so you may get it from various vendors and pay less for the medication. Indian Pharma Network is one of the most reputable and trusted manufacturers of generic medications.

Retevmo: Dosage Retevmo 40mg/80mg capsules contain selpercatinib. The patient is chosen based on the existence of a certain RET gene mutation (MTC) or rearrangement during transfection gene fusion (NSCLC or thyroid). Retevmo dosage is determined by body weight. As a result, the patient's body weight is checked before starting therapy for Retevmo, and the dosage is adjusted as necessary. Retevmo should be administered at a dose of 120 mg if the patient weighs less than 50 kg and 160 mg if the patient weighs 50 kg or more. The use of this medication requires a prescription and a qualified medical expert should initiate and oversee the course of treatment.

Retevmo: Administration Retevmo must be given orally twice daily, generally every 12 hours, until disease progression or intolerable toxicity is observed. This medication can be taken with or without food unless used with a proton pump inhibitor. It should be noted that Retevmo capsules should not be crushed or chewed but rather taken whole. After a dose is missed, only take it after at least 6 hours have passed since the previous dose. To learn more about missing Retevmo doses, please read the package leaflet or contact us at https://www.indianpharmanetwork.in/contact-us/

Retevmo: Mechanism of Action The active ingredient in Retevmo is selpercatinib, which is easily accessible at low and acceptable prices because of the low SELPERCATINIB price. It is a RET inhibitor that belongs to the class of cancer medicines known as tyrosine kinase inhibitors. Retevmo works by inhibiting the activity of aberrant proteins in the body. The body produces these proteins due to alterations in the RET gene. These aberrant proteins in patients with these alterations can cause uncontrolled cell proliferation and cancer, forming a tumour. Selpercatinib inhibits the growth and spread of cancer cells by inhibiting proteins.

Retevmo: Adverse drug reactions Despite being a powerful cancer treatment, there are some Retevmo side effects that can be mild or life-threatening. Loss of appetite, headache, dizziness, prolonged QT interval, high blood pressure, abdominal pain, diarrhoea, nausea, vomiting, constipation, dry mouth, rash, fever, tiredness, oedema, bleeding, and laboratory blood tests showing changes in liver enzymes, decreased platelet and white blood cell count, decreased magnesium, and increased creatinine are the most common adverse reactions seen after using Retevmo. One in every ten people who take this medication will suffer these negative effects. The most common major side effects of Retevmo are stomach pain, hypersensitivity, diarrhoea, and blood tests that show increases in liver enzymes, indicating liver stress. To learn more about Retevmo side effects, please contact us at https://www.indianpharmanetwork.in/contact-us/

Retevmo: Drug Interactions Certain drug interactions should be known as they can influence Retevmo dosage. Following are some of the interactions:

Coadministration of acid-reducing medications should be avoided since it lowers selpercatinib levels in plasma and may impair Retevmo anti-tumor efficacy.

Coadministration of strong and moderate CYP3A inhibitors should be avoided since it increases selpercatinib levels in plasma and increases the risk of adverse effects.

Strong and moderate CYP3A inducers: Avoid coadministration because they lower medication plasma concentration, lowering Retevmo's anti-tumor efficacy.

Substrates for CYP2C8 and CYP3A: They raise retevmo levels in plasma. Coadministration should be avoided. If coadministration is unavoidable, adjust the substrate dosage as directed on the product label.

Certain P-gp Substrates: it also boosts Retevmo concentration. As a result, co administration should be avoided. If coadministration is unavoidable, adjust the substrate dosage as directed on the product label.

Retevmo: Description Retevmo functions as a kinase inhibitor. Selpercatinib's chemical formula is C29H31N7O3, and its molecular weight is 525.61 g/mol. Selpercatinib is a white to light yellow powder that absorbs moisture from the air, making it slightly hygroscopic. The aqueous solubility of selpercatinib is pH dependent.

It is soluble only sparingly at low pH and practically insoluble at neutral pH. Selpercatinib is available as Retevmo 40 mg or 80 mg hard gelatin capsules for oral use. Click here to learn more about selpercatinib and its various applications/pharmacological activities. Call or text us at https://www.indianpharmanetwork.in/contact-us/

Retevmo: Composition and storage Microcrystalline cellulose and colloidal silicon dioxide are inactive components in each medication capsule. Gelatin, titanium dioxide, ferric oxide black, and black ink are all included in the 40 mg capsule shell. Gelatin, titanium dioxide, FD&C blue #1, and black ink are all included in the Retevmo 80 mg capsule shell. Shellac, potassium hydroxide, and ferric oxide black are all ingredients in the black ink. Patients must read all the ingredients and inform their doctor if they are allergic to them. In addition, the active component is selpercatinib. Retevmo capsules should be kept at room temperature, between 68°F and 77°F (20°C and 25°C). A bottle of 40 mg contains 60 capsules, whereas a container of 80 mg contains 60 and 120 counts. Both 40 mg and 80 mg are effective.

Retevmo: Use in a specific population

Pregnancy- Based on animal research and the mechanism of action of selpercatinib, it has been discovered that it can actively cause foetal damage when taken by pregnant women. As a result, pregnant women should avoid taking it. In an emergency, seek medical help.

Lactation-There is no information on the presence of selpercatinib in milk. There have been no investigations on its metabolites in human milk, their effects on the breastfed kid, or milk production. However, due to the possibility of major adverse reactions in breastfed children, it is advised not to nurse during and one week after the last dose of Retevmo treatment to avoid ill effects on the kid.

Retevmo: Effects shown in studies One of the key research demonstrates the effects of sepercatinib. The study discovered that Retevmo efficiently reduced tumour size in cancer patients caused by RET gene mutations. Individual effects of selpercatinib (Retevmo) were examined in this trial, but they were not compared to other medications, dummy treatments, or placebo. The medicine reduces the size of the tumour in all situations, whether it is for advanced non-small cell lung cancer, advanced thyroid cancer, or advanced medullary thyroid cancer. This excellent medication is on the market and can be obtained from any authorized seller. Furthermore, the Retevmo price is low and quite fair, making them simply adopted.

Retevmo: Availability This effective medicine, used to treat non-small cell lung cancer and thyroid/medullary thyroid cancer, is now available in India. After being diagnosed with an FDA-approved test, Retevmo treatment can begin under the supervision of qualified medical health professionals and doctors. It should be noted that, despite its low Retevmo cost, Retevmo is not a prescription medicine. A legal authorisation and prescription are required for the sale and purchase of Retevmo, respectively