#vaccine design

[howdoesone]

How does one develop vaccines for emerging infectious diseases?

Emerging infectious diseases pose significant threats to global public health. Rapid and effective development of vaccines is crucial in mitigating the impact of these diseases. This article explores the process of developing vaccines for emerging infectious diseases, highlighting the key steps involved and the challenges faced. Understanding the development process is essential to appreciate the…

[sanurasdoodles]

[Design] Soltriamon

If you want to see more like this please support me at Subscribestar / Ko-Fi Following the completion of my Husband's Digimon, Nuanmon, I moved to make a fugi of my Digimon!... Only problem was she was one of the few that was originally incomplete! Where it took me about a day or two to finish my husband's it took about a month or so for my Digimon! Soltriamon's concept is based on alchemy and I was struggling to show off aspects of her. Thankfully I was able to overcome the issues I had with her design eventually and finish my adorable little girl! After I finish mine and my husband's fugi set, I ended up making a gift set for two of our friends who join us on the streams fairly often! So those will be next!     Please Enjoy! Art drawn by Me Art, and Soltriamon belong to Me

Posted using PostyBirb

[airocats]

[miirshroom]

Suddenly very aware of the reasons why I hesitated to re-read Ship of Magic and skipped through to Tawny Man before circling back. I want to take Ronica Vestrit gently by the hand, lead her to the ocean, and push her in to tread water until she agrees that she was insane for thinking that her child who has been interning at sea for years on a magic boat would be cool with suddenly giving that up to live on land and marry well or whatever. I do not care that she is a bereaved old woman, she had months to prepare and kept pushing to take over making decisions in sailing matters that were clearly not her expertise.

Frankly astonishing that an impulsive 18-or-19 year old like Althea didn't just walk on to the Vivacia and kill herself in despair to become one with the liveship at that point. She suddenly loses everything at once after having her sanity and desire to remain sober and proper worn away by 5 months of being micro-aggressioned by the misogynist who had been given full authority to gaslight her as he fucked up a routine 2 month voyage. For at least a little while here Kyle is the luckiest incompetent man alive that he extended their voyage just long enough that Ephron Vestrit died immediately after they arrived and Althea didn't have a chance to say her piece about his captaincy. If Kyle is such a good solid captain then what happened to the ship that he had before the Vivacia was handed to him? How is having a fleet of two family ships turning profit not better than one?? No I don't think that Althea should have been captain like she wanted (at least not yet) but Ephron did have a sensible plan for that in a successor who he has been preparing.

And then the slave trade vs. Rain Wild River trade debate comes up and Ronica has the nerve to be like, yeah the slave ship idea will surely be the better option. After several paragraphs earlier spent being morally indignant about the cheap labour of "indentured servants" that the neighbours use to work their fields. Like ??? Lady are you low-key hoping that the ship goes crazy and kills everyone on board to teach this man a lesson? You persuaded your dying husband away from every other decision he wanted for captaining the boat, but the line is drawn at letting this asshole break family tradition and take a chance at maybe dying from a plague? I guess that might be Ronica's flaw in a nutshell - she clings to the illusion of there being a "safe" and sensible traditional option in an inherently unsafe and magical setting that is experiencing a period of change.

They're all believable people in a regressive society that is also in a recession but I still want to throw things at them.

[vhaerath]

this isn't a particularly hot take or anything

[kafkasapartment]

Polio research. A light is beginning to dawn. National Foundation for Infantile Paralysis, 1948. Herbert Bayer.

[unopenablebox]

important part of my relationship is that my girlfriend isn't subscribed to money stuff, so when we walk to work together i can just describe really good money stuff bits to them

[tabletopgayventures]

Lil update

I haven't made much progress on anything. Got my flu and covid shots last week and that put me out for most of the week.

Played DnD, Starfinder, and a game called Badge Quest last week. But 3 games in a row was kinda a lot, even if I was a player in two of them.

Now this week I'm back on my normal sleep schedule, working on overviews of game systems, and planning one shots for game reviews.

All in all, I'm still cooking and you all need to get your shots if you're able.

[magratpudifoot]

Just read an article about a study concluding there was no link between the covid vaccine and changes in menstruation.

The metric they used was the number of people who went to the hospital because of heavy menstruation.

Now, I am not going to claim that this entire study was conducted by folks who have never menstruated, because I have no data on the study designers.

But I am going to strongly imply that anyone who thinks anything short of actually bleeding out would get a menstruating person to go to the hospital during an airborne pandemic, and when almost all concerns about menstruation UP TO AND INCLUDING "I BLEED INTO MY ABDOMINAL CAVITY EVERY MONTH" ARE SHRUGGED OFF BY THE MEDICAL COMMUNITY isn't listening to people who menstruate and probably shouldn't be publishing studies that will absolutely be used as the basis for future medical decisions.

[neviayue]

carnation | By Nevi Ayu E.

Ah, we're already done with a month of this new year... The happiest birthday for you January babies, I hope you started the year well and the luck clings on to you all year round!

[pomeraniandancer]

The only thing I'd add to this is that I don't think cats are the largest invasive species in the world...that dubious prize goes to the humans.

I've been seeing a lot of Discourse around outdoor cats that talks past one of the biggest problems addressing community cats/outdoor working cats so I thought I'd chime in with my two cents.

Many arguments I see just... don't think about the cats at all? Or don't consider the logistics of actually addressing the feral cat problem in a humane way. It's always about how outdoor cats shouldn't be outdoors, which is neither realistic nor helpful.

I used to volunteer at an municipal animal shelter in the USA that had a TNR program (Trap, Neuter, Return) and also adopted out community cats to local farms and businesses. Here's my side of the story.

"Your cat doesn't need to be outside" -- Yes, correct. Your domesticated (non-feral) house cat does not need to go outside at all. They can have a fully actualized life safely indoors. When I see this argument, proponents of indoor only cats are correct in most or all their arguments regarding this.

"Outdoor cats are the largest invasive species in the world, and decimate bird populations." -- This is also correct, and part of the reason why you can help by bringing your house cat indoors. Cats are the largest invasive species. Spay and Neuter your cats, bring them inside, and socialize them so they don't become feral.

"TNR doesn't work." -- False. Whether we like it or not, feral cats exist. We have two methods by which we can address the feral cat population -- decimating them (humanely euthanizing the whole colony) or TNR. For a long time, euthanasia was the preferred way to address the feral cat problem. Afterall, if the cats aren't there, doesn't that save the local wildlife population?

Except that we found, studying these colonies, that when a colony is wiped out, the cats of another colony will spread into their territory and continue to have kittens and the population of feral cats is neither controlled nor diminished.

Hence, TNR. What we found performing TNR on cat colonies was that this controlled the population of the colonies, allowing them to stay in their territory, which kept other colonies from spreading (especially colonies we hadn't performed TNR on yet). We at the shelter felt this was the most humane way to control the feral cat population and safely deflate their existence without dealing with the population blooms that euthanasia caused.

"What about kittens?" -- Kittens from these colonies were brought into the shelter, socialized, and fostered out until they could be adopted. Some of these semi-feral kittens needed special homes to be adopted into, but this was the best quality of life for these cats.

"What about cats that get missed during TNR?" -- We would return to the colony several times over a period of several years to perform TNR on the same colony. We mark cats that have been neutered by clipping their ear (this is done humanely, but is the most reliable way to tell if a cat has been neutered so the poor thing doesn't have to have surgery 3-4 times in their life). Also, during the TNR process the cats would be vaccinated to ensure disease did not spread from the colony (i.e. rabies). Still, even getting 60% of the colony TNR'd would dramatically reduce the number of kittens being added to the colony each year. This controlled the population by allowing the territory to naturally deflate in size over time, buying us time to address the larger feral cat problem.

"What if the colony was in an unsafe location?" -- There were two ways we addressed unsafe colony locations -- remember, we know that when the colony is removed, a new colony will move into its place, so we tried not to move the colony unless we really felt the cats or the public was unsafe -- one was to move the whole colony to a new location. Preferably someplace like a warehouse where we have an agreement with the owners of the warehouse. Some of the cats were even relocated to shelter grounds as our community cats. If the colony was small enough we would bring them into our Feral Cats room and adopt them out as community cats.

"What is a community cat?" -- The way the program worked, was that anyone who needed a working cat could apply to the program. These were often rural farmers or businesses with warehouses that needed rodent protection. We trained the farmers and businesses on how to acclimatize the cats to their new home, and as part of the agreement, they had to care for the cats (veterinary care, vaccinations, food and water). This gave businesses and farms an alternative to expensive and environmentally unfriendly rodent control, and also gave these feral cats good places to live out their natural lives.

"Can't you just adopt out feral cats?" -- No. Cats that have not been socialized around humans as kittens, or who have several generations of feral cat in them could not interact with humans in a way that did not cause them undue stress. This was not a humane way to handle feral cats. However, when a cat was brought into the feral cat room, they would be monitored for up to a week. If the cat displayed signs of being semi-social or fully social (hanging out outside of their den, allowing staff to pet them, showing interest in staff in the room), then we would either move the cat into the adoption room or place them in foster to be socialized before adoption. Feral cats who displayed signs of being able to live full and healthy lives with human companions were NOT adopted out as community cats. We also observed this behavior during TNRs and would do the same for those cats too.

"But aren't cats bad hunters?" -- Compared to other species, cats are not the most effective form of rodent control. This is true. However, you have to understand that feral cats exist. There is no "undo" button we can push to stop them from existing. We have to deal with the problem we have right now, which is to safely and humanely decrease the number of feral cats in our communities. And yes, we do that by using cats as rodent control in the community.

"What can I do?" -- Stop saying community cats shouldn't exist. That's not helpful and doesn't solve the problem we have. Bring your cat indoors. Spay and neuter your cats. Adopt from shelters. Volunteer with a TNR team. Support TNR efforts in your community. Recognize that those of us actively dealing with the community/feral problem are trying to do what is in the best interest of our communities and the animals we love. We aren't sitting over here saying these cats should exist -- a feral cat will not have the same quality of life as one that is indoors with a family -- but we have to address the problem in practical terms. We don't have the moral high ground to just do nothing while pontificating solutions that have no basis in actuality.

And yes, it's okay to celebrate community cats. If your local farm has a couple of working cats, that means that farm is helping participate in the safe deflation of the feral cat population. Don't shame a farm or business for using community cats. We're all doing the best we can to solve the problem that we have.

[dr-afsaeed]

Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design

Nature Reviews Immunology, Published online: 13 June 2025; doi:10.1038/s41577-025-01192-z T cells have an essential role in immune responses to Mycobacterium tuberculosis, but the mechanisms by which they may provide protective immunity remain poorly understood. This Review explores the knowns and unknowns of T cell immunity in tuberculosis and how recent technologies may inform the design of T…

[iamarafat10]

https://www.fiverr.com/iamarafat10

[plant-kink]

So when can we start getting our parasitic brain worm injections? I desperately need someone else to take the wheel in here

[studioskies]

Bio-Angle Vacs Rebranding Art direction, logo design, visual identity - Created at ZHOA Approved design

[dearcrushsblog]

Imagine being an HCP, working in a high-pressure environment where time is of the essence. You’re responsible for ensuring your patients have access to life-saving vaccines, yet the process for ordering them remains stuck in the past. Paper orders, phone calls, and face-to-face interactions were still the norm — methods that, while familiar, were time-consuming and inefficient. GSK had developed an app meant to modernize this process. But when HCPs first began using it, the feedback was overwhelmingly clear: the app was clunky, unintuitive, and difficult to navigate. Out of 11,000 potential users, only 3,000 HCPs gave it a try, and even they quickly reverted to their old habits. The app, intended to simplify the process, was actually creating more barriers. As a result, vaccine sales plummeted by 70%, severely affecting accessibility. My role was to reimagine the experience from the ground up, with the HCP’s needs at the core. I had to understand their daily challenges — fast-paced environments, limited time, and the need for a seamless workflow. By diving deep into user feedback and studying their pain points, I began reshaping the app into a tool that would fit effortlessly into their workday, rather than disrupt it. The goal was simple: make the app as intuitive and accessible as possible, ensuring that HCPs could easily order vaccines with minimal effort. By focusing on usability and streamlining the interface, we aimed to increase engagement, sales, and, most importantly, vaccine accessibility. This project was not just about fixing an app — it was about empowering healthcare professionals to better serve their patients by giving them the tools they needed to do their jobs more efficiently. And in doing so, we were able to turn things around, increasing both sales and usage, and ultimately improving the availability of essential vaccines.