#Blast Analysis Software

[extremeloading11]

Advanced Blast Analysis Software for Accurate Structural Safety Assessments

Understanding how structures respond to high-impact explosions is critical for safety and planning. With Blast Analysis Software, engineers can simulate real-world blast scenarios, assess vulnerabilities, and design structures that withstand extreme conditions. This technology helps in reducing risks, improving response strategies, and ensuring long-term structural integrity. For those seeking precision and reliability in blast-resistant design, Extreme Loading provides cutting-edge solutions. Explore their platform today and take structural safety to the next level.

[sunshinesmebdy]

Moon in Virgo: Tidy Up Your Biz and Harvest Financial Abundance

Astrologers, rejoice! Business gurus, unite! Because under the meticulous gaze of the Moon in Virgo, it's time to blend cosmic wisdom with practical strategy. Get ready for a potent mix of grounded energy, keen analysis, and a sprinkle of earthy magic ready to boost your business and finances.

Virgo's Virgo-ness: Picture a spotless spreadsheet, a perfectly balanced budget, and a to-do list so organized it whispers sweet satisfaction. That's Virgo's domain. When the Moon dances through this earth sign, it brings a laser focus on details, a knack for efficiency, and an urge to declutter both your physical and financial spaces.

Business Benefits:

Sharpened Skills: Hone your expertise, take that online course, or finally master that new software. Virgo's energy fuels learning and skill development, making you a powerhouse of knowledge and competence.

Channel your inner Hermione Granger under the Virgo Moon! Devour knowledge like polyjuice potion, mastering that new software with flick-of-the-wand ease. Whether it's an online course on astrological forecasting or the intricacies of blockchain technology, Virgo's studious energy makes you a sponge for information, transforming you into a confident, competence-wielding powerhouse ready to tackle any business challenge.

Streamlined Operations: Virgo loves a well-oiled machine. Use this lunar phase to audit your business processes, identify bottlenecks, and implement systems that save time and resources.

Don your efficiency hat, because under the meticulous Virgo Moon, streamlining your business becomes a cosmically ordained quest. Scrutinize processes like a celestial accountant, unearthing time-sucking bottlenecks and banishing them with automated spells (aka, handy new systems). Watch as email chains unfurl into streamlined communication channels, meetings morph into laser-focused action sessions, and your once-chaotic workflow hums like a perfectly tuned engine, freeing up precious time and resources for your entrepreneurial magic to truly shine.

Networking with Purpose: Quality over quantity is Virgo's motto. Connect with potential clients or collaborators who share your values and expertise. Think strategic partnerships, not random coffee chats.

Forget the business card bingo of generic gatherings – Virgo's discerning Moon demands quality connections. Seek out collaborators and clients who mirror your values and expertise, like kindred spirits drawn together by constellations of shared passion. Think chess match, not cocktail party. Craft targeted pitches that resonate with their specific needs, and cultivate strategic partnerships that feel like cosmically ordained alliances. This intentional networking isn't about collecting contacts, it's about igniting mutually beneficial collaborations that propel your business towards the stars.

Marketing Magic: Craft targeted campaigns that speak directly to your ideal customer's needs. Virgo's analytical prowess helps you understand your audience and deliver messaging that resonates.

Under the analytical gaze of the Virgo Moon, ditch the shotgun marketing blasts and unleash laser-focused campaigns that whisper sweet nothings to your ideal customer's soul. Virgo's eagle eye pinpoints their deepest desires and pain points, transforming you into a messaging maestro. Craft content that speaks their language, addresses their specific struggles, and showcases your solutions like the missing puzzle piece to their perfect life. Let go of generic pitches and embrace storytelling that resonates with their values, because under this lunar influence, targeted marketing isn't just effective, it's downright magical.

Financial Fortunes:

Budgeting Bliss: Break out the spreadsheets and get granular. Categorize expenses, track income, and create a budget that feels secure and sustainable. Virgo loves a balanced bottom line.

Spreadsheets sing and budgets balance under the Virgo Moon! Unleash your inner accounting alchemist and transform financial chaos into crystal-clear clarity. Categorize expenses with the precision of a cosmic librarian, track every penny like a moonbeam, and craft a budget that feels not like a restrictive cage, but a beautifully organized, secure haven for your financial future. Virgo craves equilibrium, so find that sweet spot where income and outgoings waltz in perfect harmony, leaving you feeling abundant and empowered, the maestro of your own financial orchestra.

Debt Disposal: Tackle outstanding debts with renewed determination. Negotiate better terms, make extra payments, and experience the liberation of financial freedom.

Ditch the debt demon and embrace the warrior spirit under the Virgo Moon! Channel your inner debt disposal dragon, breathing fire upon outstanding balances with renewed determination. Hone your negotiation skills like a celestial diplomat, securing lower interest rates and crafting repayment plans that fit your budget like a cosmic glove. Make extra payments with the fervor of a moonbeam illuminating a dark cave, watching those numbers shrink faster than a vampire in sunlight. Embrace the sweet liberation of financial freedom, feeling the weight of debt lift like a cosmic spell dissolving, leaving you empowered and ready to conquer your financial Everest.

Savvy Investments: Research, compare, analyze – Virgo's energy is perfect for making informed investment decisions. Seek advice from trusted professionals and prioritize long-term stability over short-term gains.

Transform into a celestial stockbroker under the Virgo Moon! Put on your research goggles and analyze potential investments like a cosmic detective, comparing, contrasting, and sniffing out hidden risks. Consult trusted financial oracles for guidance, but ultimately, let your own Virgo-honed discernment be your compass. Prioritize long-term stability over fleeting trends, building a portfolio that grows like a well-tended celestial garden, not a gambler's dice roll. Embrace the slow and steady path, for under Virgo's meticulous gaze, informed investments blossom into financial freedom, one calculated decision at a time.

Unexpected Windfalls: Keep an eye out for unexpected opportunities to increase your income. Virgo favors those who put in the work, so your dedication could be rewarded with a bonus, a new client, or a lucky windfall.

Keep your antennae tuned to cosmic whispers under the Virgo Moon, for fortune often favors the prepared! Your dedication and sharpened skills could attract unexpected boons like a bonus shimmering out of thin air, a new client drawn by your newfound expertise, or a windfall landing softly as a celestial feather in your lap. Remember, Virgo rewards hard work, so keep hustling, honing, and learning, and trust that the universe may just surprise you with a bonus chapter in your financial story.

Bonus Tip: Embrace the earthy magic of Virgo! Surround yourself with green spaces, incorporate crystals like citrine and jade into your workspace, and practice grounding exercises to channel the Moon's practical energy.

So, there you have it! The Moon in Virgo is your invitation to tidy up your biz, fine-tune your finances, and reap the rewards of your focused efforts. Remember, success is a marathon, not a sprint. Pace yourself, celebrate the small wins, and trust that under Virgo's meticulous guidance, your business and finances will shine.

Now go forth and conquer, astrologically savvy entrepreneurs! Your financial stars are aligned.

[beardedmrbean]

NASA and Boeing were forced to stand down from an attempted launch to the International Space Station on Monday because of a last-minute issue that cropped up with a valve on the spacecraft’s rocket.

Boeing’s Starliner capsule had been scheduled to lift off at 10:34 p.m. ET from Florida’s Cape Canaveral Space Force Station on its first crewed test flight. NASA astronauts Barry “Butch” Wilmore and Sunita Williams were on board the capsule and strapped into their seats when the launch attempt was called off, roughly two hours ahead of the planned liftoff.

NASA announced early Tuesday that a second attempt would occur no earlier than Friday.

Mission controllers declared Monday’s launch “scrub” after an anomaly was detected on a valve on United Launch Alliance’s Atlas V rocket, which the Starliner capsule was to ride into orbit.

United Launch Alliance officials said in a post on X that the launch attempt was scrapped “out of an abundance of caution for the safety of the flight and pad crew,” adding that the team needs “additional time to complete a full assessment.”

The analysis will include whether the pressure regulation valve, located on the rocket’s upper stage, needs to be replaced, which may cause a longer delay.

The crewed Starliner flight, when it occurs, will be a crucial final test before NASA can authorize Boeing to conduct routine flights to and from the space station.

Officials at NASA and Boeing have said safety is paramount for the spacecraft’s first flight with humans onboard.

The scrubbed launch is yet another setback for Boeing, which has already dealt with years of delays and budget overruns with its Starliner program. It has fallen significantly behind SpaceX, which has been flying crewed missions to and from the space station for NASA since 2020.

Both SpaceX’s Crew Dragon capsule and Boeing’s Starliner craft were developed as part of NASA’s Commercial Crew Program. The initiative began more than a decade ago, following the retirement of the agency’s space shuttles, to support private companies in building new space vehicles to take astronauts to low-Earth orbit.

Starliner’s first uncrewed flight in 2019 was thwarted by software issues, forcing mission controllers to cut the test short before the vehicle could attempt to rendezvous and dock with the ISS. A second attempt was then delayed several times by fuel valve issues, and it wasn’t until 2022 that Boeing was able to carry out a successful uncrewed flight to and from the space station.

[biopractify]

How to Transition from Biotechnology to Bioinformatics: A Step-by-Step Guide

Biotechnology and bioinformatics are closely linked fields, but shifting from a wet lab environment to a computational approach requires strategic planning. Whether you are a student or a professional looking to make the transition, this guide will provide a step-by-step roadmap to help you navigate the shift from biotechnology to bioinformatics.

Why Transition from Biotechnology to Bioinformatics?

Bioinformatics is revolutionizing life sciences by integrating biological data with computational tools to uncover insights in genomics, proteomics, and drug discovery. The field offers diverse career opportunities in research, pharmaceuticals, healthcare, and AI-driven biological data analysis.

If you are skilled in laboratory techniques but wish to expand your expertise into data-driven biological research, bioinformatics is a rewarding career choice.

Step-by-Step Guide to Transition from Biotechnology to Bioinformatics

Step 1: Understand the Basics of Bioinformatics

Before making the switch, it’s crucial to gain a foundational understanding of bioinformatics. Here are key areas to explore:

Biological Databases – Learn about major databases like GenBank, UniProt, and Ensembl.

Genomics and Proteomics – Understand how computational methods analyze genes and proteins.

Sequence Analysis – Familiarize yourself with tools like BLAST, Clustal Omega, and FASTA.

🔹 Recommended Resources:

Online courses on Coursera, edX, or Khan Academy

Books like Bioinformatics for Dummies or Understanding Bioinformatics

Websites like NCBI, EMBL-EBI, and Expasy

Step 2: Develop Computational and Programming Skills

Bioinformatics heavily relies on coding and data analysis. You should start learning:

Python – Widely used in bioinformatics for data manipulation and analysis.

R – Great for statistical computing and visualization in genomics.

Linux/Unix – Basic command-line skills are essential for working with large datasets.

SQL – Useful for querying biological databases.

🔹 Recommended Online Courses:

Python for Bioinformatics (Udemy, DataCamp)

R for Genomics (HarvardX)

Linux Command Line Basics (Codecademy)

Step 3: Learn Bioinformatics Tools and Software

To become proficient in bioinformatics, you should practice using industry-standard tools:

Bioconductor – R-based tool for genomic data analysis.

Biopython – A powerful Python library for handling biological data.

GROMACS – Molecular dynamics simulation tool.

Rosetta – Protein modeling software.

🔹 How to Learn?

Join open-source projects on GitHub

Take part in hackathons or bioinformatics challenges on Kaggle

Explore free platforms like Galaxy Project for hands-on experience

Step 4: Work on Bioinformatics Projects

Practical experience is key. Start working on small projects such as:

✅ Analyzing gene sequences from NCBI databases ✅ Predicting protein structures using AlphaFold ✅ Visualizing genomic variations using R and Python

You can find datasets on:

NCBI GEO

1000 Genomes Project

TCGA (The Cancer Genome Atlas)

Create a GitHub portfolio to showcase your bioinformatics projects, as employers value practical work over theoretical knowledge.

Step 5: Gain Hands-on Experience with Internships

Many organizations and research institutes offer bioinformatics internships. Check opportunities at:

NCBI, EMBL-EBI, NIH (government research institutes)

Biotech and pharma companies (Roche, Pfizer, Illumina)

Academic research labs (Look for university-funded projects)

💡 Pro Tip: Join online bioinformatics communities like Biostars, Reddit r/bioinformatics, and SEQanswers to network and find opportunities.

Step 6: Earn a Certification or Higher Education

If you want to strengthen your credentials, consider:

🎓 Bioinformatics Certifications:

Coursera – Genomic Data Science (Johns Hopkins University)

edX – Bioinformatics MicroMasters (UMGC)

EMBO – Bioinformatics training courses

🎓 Master’s in Bioinformatics (optional but beneficial)

Top universities include Harvard, Stanford, ETH Zurich, University of Toronto

Step 7: Apply for Bioinformatics Jobs

Once you have gained enough skills and experience, start applying for bioinformatics roles such as:

Bioinformatics Analyst

Computational Biologist

Genomics Data Scientist

Machine Learning Scientist (Biotech)

💡 Where to Find Jobs?

LinkedIn, Indeed, Glassdoor

Biotech job boards (BioSpace, Science Careers)

Company career pages (Illumina, Thermo Fisher)

Final Thoughts

Transitioning from biotechnology to bioinformatics requires effort, but with the right skills and dedication, it is entirely achievable. Start with fundamental knowledge, build computational skills, and work on projects to gain practical experience.

Are you ready to make the switch? 🚀 Start today by exploring free online courses and practicing with real-world datasets!

[wildwinterlunas]

So, I don't exactly know if you've discussed this, but I think it's clear about what this current season is going to lead up to, and why I think it's so important to be adamant and weary about Null Sector's plans.

The evidence is there, and the claim?

Null Sector is trying to start another Omnic Crisis.

However, this one is less 'a glitch in the system'

And more, 'hitting the factory reset button and installing a virus intentionally right after.'

Why?

WELL BUCKLE UP YOUR BAMF BELT KIDDOS CAUSE THIS IS A TRIP AND A HALF.

As we know from story missions, Omnics are being subjugated and indoctrinated across the globe, all at once, in almost every part of the world by Null Sector and those helmets that quite literally place them under a catatonic state and wipe the Omnic's memories.

Torbjörn's analysis on the helmet is very clear when he brings up a very important piece of information:

"I don't know...this device is a nasty piece of work. I think I can get it off, but the bigger problem is, I'm not reading anything in the Omnic's memory banks."

"He's still alive, but it's like the essence of who he is,...is gone."

Now, when we say essence, I'm pretty sure we're saying the Iris, or Aurora's essence that was implemented during the awakening. Now I get what you're thinking. 'Ok Anon #324, but if the Iris gets removed, then why is Ramattra talking about Iris? During the Toronto mission?'

And to you- I say- oh ho ho, my dear, that's exactly what we should be fearing. Let it tie into the fact that there's also one of these Voicelines from Ram when talking about his favorite animal:

"Ants. They build marvelous structures and cooperate when threatened. I find them... Inspirational."

Toronto mission, hell, even the humans are terrified. Everyone is swarming in groups. It's not just gameplay either, when Sojourn is directing the groups of scared Omnics onto the ferry boat, it only proves Ram's point more. People are scared, people are grouping together to fight back, hide, run, and that's exactly what NS wants.

Not only is Null Sector wiping the Iris and awakening out of the Omnics altogether, they're creating a brand new version of the 'Iris'...let's call it 'Pink Eye' cause from what I've seen it's highly contagious. Not only from wiping memories, but also using the memories of strong fighters as well. Human's memories. (*Cough Cough* Ana.)

Have you heard Ram talking during the Toronto mission? He specifically states:

"Together, our one minded purpose. We will make this world, our paradise."

"We welcome you into the Iris."

----------

You let me know what you think about this. I wanna hear some raw thoughts. Big brain mode, no idea is a bad idea. I'm hungry for knowledge.

All I know is that, a couple of things could happen.

If those helmets are taken off, someone is going to have to sacrifice their memories either to bring back the original Aurora awakening and reinstall essence to the Omnics. Wonder who.

If NS ends up indoctrinating a major part of the Omnic population, many will die when and if those helmets do something else. If they can send out a location signal, who knows what else they'll do.

If sentience is reestablished into Omnics and possibly other software coding, this'll be one hell of a trip for all those Null Sector bots.

Man you had a brain blast and I. AM. LOVING IT!

Honestly I love your theory and I don't think there is much to add! It also is a good way to bring in the Junkers cause apparently he found the secret to Omnic life in the Australian omnium-

That could be a way to bring all the omnics back, the Australian Omnium was the place where Aroura was built after all. They could end up brining a second awakening, some residual of Aroura left in the Omnium. It could also lead to the sentience of the Null Sector drones, specifically the bots that are based off of actual people.

Like the C-455 Sharpshooter, P-900 Warhead, S-900 Sentry, A-7000 Wargod and K-2000 Blademaster. If they all have the same glitch that A-7000 has them that is one hell of an identity crisis they're going to have.

--------------------------

All that aside, I want to present my own theory. A counter theory if you will.

And that is Ramattra doesn't know that those helmets are erasing Omnics, he just thinks they are in a catatonic state. There is no indication that Ramattra knows what the subjection helmets are actully doing to Omnics.

If you look back at Ramattra's short story there is no implication of Ramattra wanting to create a new Omnic society through hitting a reset button;

There is an indication of imprisonment, of taking away other Omnics choices in order to make them listen, but that is very different from hitting a reset button. Essentially killing the soul of Omnics. It's something I don't see Ramattra doing knowingly. However, there is a group of people who would not only do this, but has tried to do this before.

Talon.

Something I remember from the Story Missions is Torbjourn saying that the helmets put an Omnics mind in a loop. It's something I didn't think much about. Until I read "The Hero of Numbani".

In that book Sombra hack and installs a virus several Omnics around Numbani. A virus that locks Omnics in a constant loop, and gradually corrupts the Omnics memories.

Sound familiar? There is also the fact that a part of Doomfist's beliefs that are presented in that novel are anti-omnic.

Not only that but I always found it strange that Dommfist, someone who wants conflict, would help someone who has the motivation of "Peace at any cost". Ramattra goal has and still is, for freedom and peace. Something that if he were to gain, would go against Doomfist's want for conflict.

Unless Doomfist is just using Ramattra and Null Sector as a tool to create conflict, adding either an updated version of Sombra's virus (or what he thinks is an updated version), to remove Omnics souls and create a true Second Omnic Crisis.

Not only that but that could also lead into an explanation on what "The Conspiracy" is, maybe it's another God AI who wants to do what Anubis did but has learned from the mistakes of the first Crisis and is trying to make it so they are guaranteed to win.

--------------------------

Either way I am excited for both of these theories, with the first one it's going to be interesting to just explore that aspect of Null Sector, if they get Omnics back are they going to still have their memories, their souls? Are they going to resort back to their basic programming, are they going to go back to being under Anubis's control?

In the case of the second theory, how will Ramattra react if he truly doesn't know what the helmets are doing? Will he stop the invasion? Will he double down? Will he go after Talon?

It's all so interesting!

[fenrislorsrai]

A few days after the release was discovered in June 2017, Stan met with Southcreek and the Oklahoma Corporation Commission, the state’s oil and gas regulatory agency. At the meeting, the company characterized the incident as a “small spill,” the Ledgerwoods later alleged in court. It was unclear how long the leak lasted, but the saltwater plume had already saturated the soil and killed 2 acres of vegetation by the time it broke the surface, according to state oil regulators. Samples analyzed a month later by Oklahoma State University found that the soil’s concentration of chloride, which occurs in the type of salt water injected into the well, had risen to more than 12 times the state’s acceptable level and was “sufficiently high to reduce yield of even salt tolerant crops.” Other tests showed that chloride levels in the family’s water well had spiked to more than five times what the Environmental Protection Agency deems safe. The tests didn’t look for other contaminants like heavy metals that are often left behind by the oil production process. - - Don began traveling 30 miles round-trip to Walmart to buy bottled water. Stan and Tina’s steel pots rusted after being washed, and their 2-year-old great-niece’s skin became irritated and inflamed after repeatedly washing her hands while they potty-trained her. In a text message, the girl’s mother described her hands as looking like they had “a burn.” - - As is common in American oil fields, property rights in this part of Oklahoma often create split estates, where one person owns the land while another owns the underlying minerals, such as oil and gas. The owner of the minerals has a right to drill, even if the landowner would prefer they didn’t. - - But Oklahoma has more than 260,000 unplugged wells — behind only Texas — according to data from energy industry software firm Enverus. To plug and clean up the state’s wells could cost approximately $7.3 billion, according to an analysis of state records. Oklahoma has just $45 million in bonds. The oil industry’s bonds are “shockingly inadequate,” said Peter Morgan, a Sierra Club senior attorney. “It’s clear that abandoning wells and leaving communities and taxpayers to foot the bill to clean them up is baked into the oil and gas industry business model.” At the Capitol in Oklahoma City, which features repurposed oil derricks outside its main entrance, Republican state Rep. Brad Boles has tried for several years to address the shortfall. This year, he introduced a bill to create a tiered bonding system based on the number of wells a company operates, increasing the highest required bond to $150,000. [passed House, did not gt a vote in Senate] - - A stream of trucks rumbled down the Ledgerwoods’ once-quiet gravel road as workers removed enough dirt to fill 750 dump trucks and pumped more than 71,000 gallons from the Ledgerwoods’ water well. But the dangerous concentrations of chloride didn’t change, according to Fox Hollow’s report. - - Progress in the lawsuit was short-lived. In November 2019, shortly after the Ledgerwoods’ attorney sent discovery requests to Wise Oil & Gas, the company filed in a Texas court for voluntary Chapter 7 bankruptcy — a full liquidation of its assets. Company executives acknowledged they declared bankruptcy to avoid legal fees associated with the Ledgerwoods’ suit, according to court records. - - But two months later, Mullin ruled against the Ledgerwoods. He disagreed that Wise Oil & Gas had entered bankruptcy to shed bad investments and dodge cleanup obligations. He blasted the Ledgerwoods for requesting sanctions against the Cocanoughers. “Merely because the Ledgerwood Creditors have been damaged by the saltwater contamination, this does not provide them with an unfettered right to retaliate or lash out against unrelated and far-removed targets, such as the Cocanougher Sanction Targets,” Mullin wrote. If the Ledgerwoods wanted to continue seeking damages against the Cocanoughers and their businesses, they would have to pay the oil company’s attorneys’ fees, about $107,000, Mullin ruled.

It's worth reading the whole article for a breakdown of exactly HOW a company that poisoned a family's well and farm got out of fixing it or paying compensation.

Not as relevant in this particular case, but uncapped out of service wells like this are a major source of methane, an even more potent greenhouse gas than CO2

[circumlocutive]

Undergrad research blast from the past. Here I am in 2020 assembling a micro fluidic flow cell with a gold electrode block. I think I took this video for myself so I knew what to clip to what. This was when I worked with electrochemical sensors, transducing signals via impedance spectroscopy.

A lot of electrochemical techniques rely on measuring voltages or currents, but in this lab we looked at impedance- which is a fancy combination of regular resistance (like the same one from ohms law) and the imaginary portion of the resistance that arises from the alternating current we supply.

I would functionalize different groups on the gold working electrode by exposing the surface to a solution of thiolated biomarker capture groups. Thiols love to form self-assembled mono layers over gold, so anything tagged with thiol ends up sticking. [Aside: Apparently after I left the group they moved away from gold thiol interactions because they weren't strong enough to modify the electrode surface in a stable and predictable way, especially if we were flowing the solution over the surface (which we wanted to do for various automation reasons)]. The capture groups we used were various modified cyclodextrins- little sugar cups with hydrophobic pockets inside and a hydrophilic exterior. Cyclodextrins are the basis of febreeze- a cyclodextrin spray that captures odor molecules in that hydrophobic pocket so they can't interact with receptors in your nose. We focused on capturing hydrophobic things in our little pocket because many different hydrophobic biomarkers are relevant to many different diseases, but a lot of sensors struggle to interact with them in the aqueous environment of bodily fluids.

My work was two fold:

1) setting up an automated system for greater reproducibility and less human labor. I had to figure out how to get my computer, the potentiostat (which controls the alternating current put in, and reads the working electrode response), the microfluidic pump, and the actuator that switched between samples to all talk to each other so I could set up my solutions, automatically flow the thiol solution for an appropriate time and flow rate to modify the surface, then automatically flow a bio fluid sample (or rather in the beginning, pure samples of specific isolated biomarkers, tho their tendency to aggregate in aqueous solution may have changed the way they would interact with the sensor from how they would in a native environment, stabilized in blood or urine) over the electrode and cue the potentiostat for multiple measurements, and then flow cleaning solutions to clean out the tubings and renew the electrode. This involved transistor level logic (pain) and working with the potentiostat company to interact with their proprietary software language (pain) and so much dicking around with the physical components.

2) coming up with new cyclodextrin variants to test, and optimizing the parameters for surface functionalization. What concentrations and times and flow rates to use? How do different groups around the edge of the cyclodextrin affect the ability to capture distinct classes of neurotransmitters? I wasn't working with specific sensors, I was trying to get cross reactivity for the purpose of constructing nonspecific sensor arrays (less akin to antibody/antigen binding of ELISAs and more like the nonspecific combinatorial assaying you do with receptors in your tongue or nose to identify "taste profiles" or "smell profiles"), so I wanted diverse responses to diverse assortments of molecules.

Idk where I'm going with this. Mostly reminiscing. I don't miss the math or programming or the physical experience of being at the bench (I find chemistry more "fun") but I liked the ultimate goal more. I think cross reactive sensor arrays and principle component analysis could really change how we do biosample testing, and could potentially be useful for defining biochemical subtypes of subjectively defined mental illnesses.... I think that could (maybe, possibly, if things all work and are sufficiently capturing relevant variance in biochemistry from blood or piss or sweat or what have you) be a more useful way to diagnose mental illness and correlate to possible responses to medications than phenotypic analysis/interviews/questionnaires/trial and error pill prescribing.

[appliedscienceint09]

How Structural Analysis Engineering Software is Transforming Modern Engineering

Applied Science International is a premier provider of advanced Structural Analysis Engineering Software, dedicated to enhancing the way engineers and designers understand and manage structural behavior. Our software solutions are built on rigorous scientific principles and cutting-edge computational technology, offering highly accurate modeling, simulation, and visualization tools for structures under various real-world scenarios, including seismic events, blasts, and progressive collapse.

Serving structural engineers, architects, researchers, and forensic specialists, our platform provides actionable insights that improve design integrity, support compliance with international standards, and increase public safety. Whether you're optimizing a new design, performing a forensic investigation, or conducting risk assessments, our software empowers users to make informed decisions with confidence.

At Applied Science International, we pride ourselves on continuous innovation, user-centered design, and a commitment to advancing the structural engineering field. Our solutions are trusted worldwide for projects ranging from high-rise buildings to critical infrastructure. By combining intuitive interfaces with deep technical capabilities, we help professionals tackle the most complex engineering challenges.

Discover how our Structural Analysis Engineering Software can elevate your structural analysis, improve outcomes, and contribute to a safer built environment. Applied Science International—where engineering meets innovation.

Explore more insights on this topic in our blog -https://appliedscienceint09.medium.com/how-structural-analysis-engineering-software-is-transforming-modern-engineering-c47e57e57080

[amberavaava]

The Future of HR: Why AI Can’t Replace Human Empathy

Intro: So, What’s Really Gonna Happen to HR When AI Takes Over? Alright, everybody’s freaking out about robots stealing jobs and, yeah, HR is right in the mix. Tech’s getting wild, AI’s everywhere, and suddenly people are wondering: do we even need humans in Human Resources anymore? Sure, AI is a whiz at crunching numbers and blasting through paperwork, but when it comes to real, messy, emotional stuff? Sorry, Siri, you’re just not gonna cut it. Let’s talk about why empathy is still king in HR, and why you can’t just swap people for bots—no matter how shiny the tech gets.

AI in HR: Cool Tricks, Major Blind Spots Look, I’ll give credit where it’s due—AI’s killing it at the boring stuff. Sorting resumes? Done. Scheduling interviews? Easy. Creepy-fast data analysis? Absolutely. It’s like having a tireless intern who never sleeps or asks for a raise. But here’s the thing: as soon as you need someone to pick up on a weird vibe in the office, or talk someone through a bad day at work, AI’s just totally lost. Machines don’t “get” people. They don’t know when you’re faking a smile or when someone’s about to quit because their boss is a jerk. That’s the stuff that keeps a team together—and that’s where humans wipe the floor with tech.

Human Empathy: The Secret Sauce for Happy Employees If you’ve ever worked anywhere, you know when your boss actually cares versus when they’re reciting lines from some corporate handbook. Empathy isn’t a checkbox—it’s the whole deal. When someone listens to you, really listens, you stick around. You work harder. You care back. Try getting that from a chatbot. No matter how slick the software, people want to feel seen and heard by… well, actual people. That’s what keeps folks from jumping ship every six months.

Finding That Sweet Spot: Not Too Robotic, Not Too Mushy So, what’s the move? HR can’t just go full robot, but drowning in feelings isn’t great either. Smart HR pros know how to use AI for the grunt work but put humans front and center where it counts. Stuff like real conversations, empathy workshops, and, you know, actually checking in on people. Use AI to get the numbers right, then let humans do the heart stuff. It’s not rocket science, but you’d be surprised how many companies mess it up.

Real-Life Example: Robots + People = Dream Team (If You Don’t Screw It Up) Okay, so here’s a quick story: this giant international company rolled out a bunch of AI tools—resume bots, analytics, the whole shebang. Did HR have a meltdown? Nope. They doubled down on empathy training and made sure every manager actually talked to their team, not just spammed them with reports. Guess what? Productivity went up, and people didn’t feel like cogs in the machine. That’s how you do it—tech plus heart, not one or the other

One Last Thing: Ethics. Don’t Be Creepy. Look, just because you can automate something doesn’t mean you should. AI brings up all sorts of sticky questions—privacy, bias, weird robot decisions that make zero sense. HR’s job isn’t just to make things run faster; it’s to make sure people aren’t getting screwed over by some faceless algorithm. Set rules. Stay transparent. Keep it fair. Otherwise, you’re just building a cold, dystopian office no one wants to work in. And honestly, who’s got time for that?

[manostaxx]

Primer design. Plasmid mapping. DNA sequence analysis. We all have our favorite tools for tackling these particular tasks, but they tend to be scattered about the internet. To help you keep your virtual molecular biology toolbox organized, today’s post features a list of free online molecular biology tools all in one place. Plasmid mapping These tools are for viewing, editing or making plasmid maps, but can also analyze and annotate any DNA sequence. SnapGene Viewer: The free SnapGene Viewer is great for looking at plasmid maps and viewing sequencing traces, while the paid version provides more tools for plasmid mapping and design (Figure 1). Benchling: While you might think of Benchling as an electronic lab notebook, it also has a suite of molecular biology tools and can make plasmid maps. Free for academic users. Serial Cloner: Free desktop-based software for plasmid design and mapping. ApE (A plasmid Editor): A free, donation-based plasmid analysis tool including editing, annotating, creating maps, and more. This tool is maintained by M. Wayne Davis from the University of Utah.   Figure 1: A plasmid map created in SnapGene of Blue Flame plasmid pET21a-BirA.   DNA / protein database search and analysis tools Addgene’s analyze sequence tool: Annotates features, BLASTs, aligns, digests, and translates a sequence. NEBCutter2: For finding restriction enzyme cut sites Webcutter 2.0: For finding restriction enzyme cut sites Open reading frame finder Addgene vector database: Find sequences for plasmids assembled from publications and commercially available sources, as well as those deposited with Addgene. NCBI BLAST: Compares nucleotide or protein sequences to sequences in a database ExPASy translation tool: Translates a DNA sequence using all six open reading frames UniProt: A database of protein sequence and functional information, such as expression patterns, post-translational modifications and polymorphisms Codon optimization tool: To access this tool, set up an IDT account. Figure 2: Addgene’s Analyze Sequence tool.   DNA sequence manipulation tools Sometimes DNA sequences need to be “cleaned up” or changed in some way before you can analyze them. These tools help with that. DNA sequence reverse complement tool: Enter a DNA sequence and the program will give you the reverse sequence, complement sequence, or reverse and complement sequence. Filter DNA tool: Removes non-DNA characters, such as numbers and blank spaces, from the text of a DNA sequence, making it ready to copy and paste into other applications Primer design tools Many of the above-listed plasmid mapping tools have built-in primer design tools, but here are a few stand-alone sites for general primer design, as well as primer design for different cloning applications. Primer3 and Primer3Plus: For general primer design Design primers for Goldengate cloning  Design primers for In-Fusion Cloning Design primers for Gibson Assembly and NEB HiFi DNA Assembly OligoAnalyzer Tool from IDT: For hairpin analysis, Tm and primer dimer estimation, and other primer characteristics. NEB Data-optimized Assembly Design (DAD): This tool designs overhang sets for high complexity Golden Gate Reactions Cloning ligation reaction calculators These links can help you calculate how much insert and backbone you need for different types of cloning methods, such as restriction enzyme cloning, Gibson assembly, or In-Fusion cloning. NEB Ligation Calculator: This tool works for any cloning method. You can select from five different insert:backbone ratios. In-Fusion cloning molar ratio calculators   Lab math calculators These calculators can help you with common calculations performed in the lab. Molarity calculator Promega’s Biomath Calculators Primer resuspension calculator (sign-in required.) DailyCalcs Science Calculator app for iPhone Reagent and Data Repositories These links can help you find experimental and/or validation data on molecular biology tools. Addgene Data Hub: A data repository for validation data on Addgene/CLOVER viral vectors. Ca...

[extremeloading11]

Integrating Advanced Software for Structural Safety and Analysis

Ensuring structural safety is vital in modern engineering, and advanced software tools are integral to this process. Blast Analysis Software helps simulate the impact of explosions on structures, while Wind Load Software ensures that buildings can withstand strong wind forces. Progressive Collapse Software helps prevent chain-reaction failures in structures, and Demolition Software ensures safe and controlled demolitions. Together, these tools enhance the design, safety, and longevity of buildings.

Read the complete Blog at: https://extremeloadingfor.blogspot.com/2024/09/integrating-advanced-software-for.html

[messungauto]

Choosing the Right PLC: A Guide for Small & Medium Industries

Finding the Perfect PLC for Your Application.

In today’s fast-paced industrial environment, choosing the right Programmable Logic Controller (PLC) is crucial for ensuring efficiency, reliability, and scalability. Small and medium industries often struggle to find a cost-effective solution that balances performance with flexibility.

Whether you're automating a machine tool, packaging line, water treatment plant, or a textile process, selecting the right PLC can significantly impact your productivity.

Key Factors to Consider When Selecting a PLC

✅ Application Complexity – Does your process require simple ON/OFF control, or do you need advanced motion and data handling?

✅ I/O Requirements – How many digital and analog inputs/outputs do you need?

✅ Communication & Connectivity – Is the PLC compatible with industry-standard protocols like Modbus, Ethernet/IP, or MQTT?

✅ Scalability & Future Expansion – Can the PLC adapt to your growing automation needs?

✅ Advanced Control Capabilities – Does the PLC support PID control for maintaining precise process parameters?

✅ Ease of Programming – Is the PLC supported by intuitive, user-friendly programming software?

✅ Cost & Support – Does the solution offer the best value without compromising on quality and support?

Messung XMPRO Series: Designed for Your Industrial Needs

At Messung, we understand the challenges industries face when selecting automation solutions. Our XMPRO-10 PLC series offers:

🔹 Compact & Scalable Solutions – Suitable for both small and medium industries, ensuring cost-effectiveness without performance compromises.

🔹 Advanced Connectivity – Supports Modbus, Ethernet/IP, and MQTT for seamless data exchange, real-time remote monitoring, and Industry 4.0 integration.

🔹 Precision Process Control with PID – Ideal for temperature, pressure, and flow control applications, ensuring optimized performance with minimal manual intervention.

🔹 User-Friendly Programming – Developed with XMPS-2000 software, making programming intuitive and efficient.

🔹 High Reliability & Performance – Built with robust hardware and backed by 4 Decades of expertise in industrial automation.

Proven Applications of XMPRO-10 PLC

Messung’s XMPRO-10 PLC has already been successfully implemented in a variety of industrial applications, including:

Testing & Automotive Industry:

✔Pressure Testing Machines – Ensuring precise pressure control.

✔ Leak Testing Machines – High-accuracy monitoring for quality assurance.

✔ Engine Test Systems/Benches – Automating real-time engine performance analysis.

✔ Vehicle & Transmission Test Machines – Advanced testing for automotive components.

✔ Battery Tray Leak Test Machines – Reliable testing solutions for EV battery components.

Manufacturing & Process Automation:

✔ Drilling, Tapping & Press Machines – Improving precision and repeatability.

✔ Core Shooters (Forging) – Optimizing metal casting processes.

✔ Shot Blasting Machines – Automating surface treatment applications.

✔ Salt Spray Chamber/Corrosion Testing – Enhancing material durability testing.

✔ Automated Liquid Filling Machines – Efficient and precise liquid handling solutions.

Textile & Environmental Control:

✔ Yarn Steaming Autoclaves – Optimized temperature and pressure regulation.

✔ Stator Varnishing Machines – Enhancing insulation durability in motor manufacturing.

✔ STP, ETP, WTP – Reliable PLC-based automation for sewage, effluent, and water treatment plants.

✔ Industrial Water Chillers & HVAC Systems – Seamless integration for environmental control solutions.

✔ AHU & Dehumidifiers – Smart control for air handling and moisture management.

Upgrade to a Smarter PLC Today!

Choosing the right PLC doesn’t have to be complicated. Messung’s XMPRO-10 PLC series is designed to meet the diverse needs of small and medium industries, delivering cutting-edge automation at an affordable cost.💡 Want expert guidance? Our team can help you select the best PLC for your specific application. Contact us today!

[henmath]

The Future of CRM Software: Trends, Tools, and Tech to Watch

In today’s digital-first world, customer experience is everything. Businesses no longer compete solely on product or price but on the ability to build and nurture lasting customer relationships. That’s where Customer Relationship Management (CRM) software plays a critical role.

As we look toward the future, CRM solutions are becoming more intelligent, integrated, and customer-centric than ever before. In this blog, we’ll explore the key trends, emerging technologies, and essential tools shaping the future of CRM software. Know More

Why CRM Software Still Matters

CRM software has evolved from simple contact management systems into powerful platforms that integrate sales, marketing, customer service, and analytics. With customer expectations rising and data becoming more valuable, a robust CRM is no longer a nice-to-have — it’s a must-have.

From small startups to global enterprises, CRM systems help businesses:

Track customer interactions and sales pipelines

Improve communication across departments

Analyze customer behavior and preferences

Personalize marketing efforts

Enhance customer satisfaction and retention

Key Trends Shaping the Future of CRM

1. AI and Machine Learning Integration

Artificial Intelligence (AI) is revolutionizing CRM systems. AI-driven CRMs can automate routine tasks, offer smart recommendations, and predict customer behavior. Features like chatbots, sentiment analysis, lead scoring, and predictive forecasting are becoming standard.

Example: Salesforce’s Einstein AI and Zoho’s Zia are built-in assistants that analyze customer data to provide actionable insights.

2. Hyper-Personalization

Modern customers expect personalized experiences across all touchpoints. Future CRM systems will use real-time data, past purchase behavior, and browsing patterns to deliver tailored content and recommendations.

How it works: Instead of sending a generic email blast, your CRM can segment audiences and send hyper-targeted messages based on individual preferences.

3. Omnichannel Customer Engagement

The customer journey is no longer linear. People interact with brands through email, phone, social media, live chat, and more. Next-gen CRM software is evolving to support seamless omnichannel communication from a single dashboard.

Impact: It ensures that no matter where or how a customer connects, their experience is consistent and context-aware.

4. Mobile-First and Remote CRM

With remote work on the rise, CRM software is becoming increasingly mobile-friendly. Sales teams, field agents, and support staff need to access customer information anytime, anywhere.

Mobile CRM apps offer features like call logging, voice-to-text notes, and offline access — crucial for staying productive on the go.

5. Low-Code and No-Code Customization

Businesses want the flexibility to tailor their CRM without relying heavily on developers. Low-code and no-code platforms enable users to design workflows, create dashboards, and build integrations with minimal technical effort.

Tools like: Creatio, Zoho Creator, and Microsoft Power Apps are leading the way in this space.

Technologies Driving CRM Innovation

Here are some of the technologies powering the next generation of CRM platforms:

✅ Cloud Computing

Cloud-based CRMs offer scalability, accessibility, and reduced infrastructure costs. They allow real-time updates and secure access from anywhere.

✅ Big Data Analytics

CRMs are now integrated with data analytics tools that help businesses extract deeper insights from large volumes of customer data, improving decision-making.

✅ Natural Language Processing (NLP)

NLP enhances voice search, smart assistants, and sentiment analysis features within CRM platforms, making human-computer interaction smoother.

✅ Internet of Things (IoT)

IoT-connected devices can feed real-time data into CRM systems. For example, a smart device can alert a support team about issues before the customer even reports them.

✅ Blockchain

Though still emerging in the CRM space, blockchain technology has the potential to enhance data privacy, transparency, and trust in customer records.

CRM Tools to Watch in 2025 and Beyond

Here’s a list of CRM tools that are adapting well to future demands:

Salesforce CRM: Known for its robust ecosystem and powerful AI features

HubSpot CRM: Great for small to mid-sized businesses with a focus on inbound marketing

Zoho CRM: Offers flexibility, AI integration, and affordability

Microsoft Dynamics 365: Ideal for enterprises needing CRM + ERP integration

Freshsales (by Freshworks): Focused on AI-driven sales automation for growing teams

Each of these platforms is incorporating automation, personalization, and analytics into their core features.

What Businesses Should Do to Stay Ahead

To prepare for the future of CRM, businesses should:

Adopt CRM systems that support AI and automation

Ensure mobile and omnichannel readiness

Invest in staff training to maximize CRM usage

Use CRM analytics for customer insights

Continuously update and customize the CRM as business needs evolve

Final Thoughts

The future of CRM software is not just about managing contacts or closing deals — it’s about understanding, anticipating, and enhancing the entire customer journey. With emerging technologies like AI, big data, and automation reshaping CRM platforms, the companies that embrace these innovations will be the ones that thrive in the customer-centric era.

As tools become smarter and more intuitive, CRM software will no longer be a backend tool — it will be at the heart of every successful customer strategy.

[education3244]

Concrete structures react differently to static and dynamic loads. For safety-critical applications, their response must be properly predicted under high strain rates of aircraft impact, blast, or earthquakes. One of the best ways to do this is by employing the Abaqus Concrete Damage Plasticity (CDP) model. The material model is widely used in Abaqus structural analyses to simulate the inelastic and damage response of concrete under a broad spectrum of loading conditions.

[shreejicorp]

Understanding Nozzle Manufacturing: A Comprehensive Overview

Nozzles, seemingly simple devices, play a critical role in a vast array of industrial and domestic applications. From the precise spraying of agricultural pesticides to the high-pressure cleaning of industrial equipment, the performance of these components directly impacts efficiency and effectiveness. This article provides a comprehensive overview of nozzle manufacturing, exploring the processes, materials, and technologies that contribute to their creation.

The Foundation: Materials and Design Considerations

The manufacturing of a nozzle begins with careful material selection, dictated by the intended application and operating environment. Common materials include stainless steel, brass, various plastics, and ceramics. Stainless steel, known for its corrosion resistance and durability, is frequently used in high-pressure applications. Brass offers excellent machinability and thermal conductivity, making it suitable for general-purpose nozzles. Plastics, with their chemical resistance and cost-effectiveness, are employed in applications where lightweight and non-corrosive properties are essential. Ceramics, with their extreme hardness and heat resistance, are used in demanding applications like abrasive blasting.  

Design considerations are equally crucial. The shape, size, and internal geometry of a nozzle significantly influence the spray pattern, flow rate, and droplet size. Engineers employ sophisticated design software to optimize these parameters, ensuring the nozzle meets specific performance requirements. Factors like spray angle, orifice size, and internal flow paths are meticulously calculated and refined.  

The Manufacturing Processes: Precision and Control

The manufacturing processes employed vary depending on the nozzle's design, material, and required precision. Common techniques include:

Machining: Traditional machining processes, such as turning, milling, and drilling, are used to create nozzles from metal or plastic stock. Computer Numerical Control (CNC) machining ensures high precision and repeatability, vital for complex nozzle designs.  

Injection Molding: For plastic nozzles, injection molding offers a cost-effective method for mass production. Molten plastic is injected into a mold cavity, creating a precise replica of the desired nozzle shape.  

Casting: Casting processes, such as investment casting or die casting, are used for metal nozzles, particularly those with complex geometries. Molten metal is poured into a mold, solidifying into the desired shape.  

3D Printing: Additive manufacturing, or 3D printing, is increasingly used for prototyping and producing custom nozzles. This technology allows for the creation of intricate internal geometries that are difficult or impossible to achieve with traditional methods.  

Sintering: For ceramic nozzles, sintering is employed. Ceramic powder is compacted and heated to high temperatures, fusing the particles together and creating a dense, durable component.  

Quality Control: Ensuring Performance and Reliability

Quality control is paramount in nozzle manufacturing. Manufacturers employ rigorous testing procedures to ensure their products meet stringent performance standards. These tests may include flow rate measurements, spray pattern analysis, and pressure testing. Advanced imaging techniques and laser measurement systems are used to verify dimensional accuracy and surface finish.  

The Future of Nozzle Manufacturing: Innovation and Advancements

The nozzle manufacturing industry is constantly evolving, driven by technological advancements and increasing demands for precision and efficiency. 3D printing is revolutionizing the production of custom nozzles, while advanced materials and coatings are improving performance and durability. As industries continue to seek optimized solutions, nozzle manufacturers will continue to innovate, pushing the boundaries of what is possible.

[dsp-consultants]

Blast Mitigation Design: Ensuring Structural Resilience in Saudi Arabia

In today’s rapidly evolving built environment, safeguarding infrastructure against explosive threats is a critical priority. Blast mitigation design plays a crucial role in ensuring the safety of buildings, occupants, and surrounding environments. At DSP Consultants, we specialize in providing comprehensive blast analysis reports tailored to the unique requirements of our clients in Saudi Arabia. Our meticulous approach integrates structural engineering, advanced modeling, and expert risk assessment to deliver resilient and effective blast mitigation solutions.

Key Steps in Blast Mitigation Design

1. Defining the Scope of the Project

Every project has specific objectives that dictate the blast mitigation design. To ensure optimal protection, we establish key specifications such as:

Type of structure involved (commercial, residential, industrial, or critical infrastructure)

Level of protection required based on the risk assessment

Type and quantity of occupants in the building

The surrounding environment and potential external risks

2. Threat and Risk Assessment

Identifying potential threats is the foundation of an effective blast mitigation strategy. Our expert team conducts in-depth assessments that consider:

The type of explosion (accidental or intentional)

The location of the explosion relative to the structure

Possible causes of the explosion, such as industrial accidents or terrorist threats

3. Site Visit and Structural Assessment

A thorough understanding of the existing structural integrity is crucial. Our consultants conduct site surveys to analyze the behavior of structures under blast conditions, including:

Evaluating the impact of blast loads on the structure

Identifying structural weak points that require reinforcement

Determining the material composition of the building to assess vulnerability

4. Blast Load Categorization and Analysis

Using state-of-the-art simulation software, we model various blast explosion scenarios to predict their impact. This enables us to design effective mitigation measures by:

Establishing design-based threats that align with real-world risks

Creating 2D and 3D structural models to analyze blast wave effects

Determining critical factors such as pressure, impulse, and duration of the blast impact

Delivering Cutting-Edge Blast Mitigation Solutions in Saudi Arabia

DSP Consultants employs cutting-edge technology and engineering expertise to develop customized blast mitigation designs. Our approach ensures that buildings meet international safety standards while maintaining functional and aesthetic integrity. By integrating advanced structural analysis, we provide tailored solutions that enhance the resilience of infrastructure against potential blast threats.

As Saudi Arabia continues its ambitious urban development, implementing robust blast mitigation strategies is imperative for protecting people and assets. At DSP Consultants, we remain committed to delivering innovative, data-driven solutions that set new benchmarks in structural safety and security.

For expert consultation on blast mitigation design, contact DSP Consultants today and ensure your infrastructure is built to withstand future challenges.