#Clinical trial translation

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What is Linguistic Validation?

What is Linguistic Validation? Ensuring Accurate and Culturally Relevant Communication Linguistic validation services are part of an intensive process that ensures translated content retains its original meaning and cultural nuances. This method involves more than just translation; it scrutinises accuracy, cultural relevance, and appropriateness. Experts compare the translated text with the…

[biomedicatranslations]

Biotechnology Translations Service| Biomedica Translations

Biomedica Translations is a leading provider of Biotechnology Translations Service for clients in the pharmaceutical and biotech industry for regulatory submissions, manufacturing, marketing and post-marketing surveillance or pharmacovigilance.Our in-depth knowledge of the product life cycle from chemical manufacturing through clinical trial, market authorization submission, and marketing communications means we are uniquely qualified to support the translation needs of this highly specialized industry. Visit us - https://www.biomedicatranslations.com/pharmaceutical-biotechnology.php

[freeinfo1]

New Target Identified to Prevent Blood Cancer: Groundbreaking Research in Translational Medicine

New Target Identified to Prevent Blood Cancer: Groundbreaking Research in Translational Medicine

Yet again translational medication has gained amazing headway in the battle against blood malignant growth. A new report by a group of regarded specialists has distinguished another objective that might hold the way to forestalling blood malignant growth. The pivotal discoveries of this study can possibly alter the area of oncology and open new roads for the improvement of successful medicines for blood problems.

Grasping Blood Malignant growth

Blood disease, otherwise called hematological danger, is a sort of malignant growth that begins in the phones of the blood and bone marrow. It incorporates different sorts, including leukemia, lymphoma, and various myeloma, which can devastatingly affect the body's capacity to create sound platelets and battle contaminations. Blood malignant growth influences a large number of individuals overall and postures critical difficulties to the two patients and medical services suppliers.

Distinguishing Another Objective: A Unique advantage in Blood Disease Exploration

The new review distributed in a main clinical diary has distinguished a clever objective that can possibly forestall blood disease. The examination group, drove by famous researchers in the field of translational medication, used state of the art methods and directed careful tests to uncover this pivotal revelation.

As per the review, the recently distinguished target is a particular protein that assumes a urgent part in the turn of events and movement of blood disease. This protein, which was already obscure with regards to blood disease research, has been viewed as profoundly communicated in disease cells and is engaged with advancing cancer development and endurance. The discoveries of this study have revealed new insight into the sub-atomic systems hidden blood malignant growth and have opened up intriguing opportunities for the improvement of designated treatments.

Suggestions for Blood Disease Treatment

The distinguishing proof of this new objective has huge ramifications for the therapy of blood malignant growth. The review discoveries propose that by focusing on this protein, it could be feasible to restrain the development and endurance of disease cells, accordingly forestalling the movement of blood malignant growth. This addresses a pivotal methodology that might actually reform the area of oncology and change how blood malignant growth is made due.

The analysts accept that this revelation could prepare for the advancement of novel treatments that explicitly focus on this protein, prompting more powerful and less poisonous therapies for blood malignant growth patients. The expected advantages of such designated treatments are enormous, as they could essentially work on the anticipation and personal satisfaction for patients fighting blood malignant growth.

Future Bearings and Effects on Accuracy Medication

The distinguishing proof of this new objective has extensive ramifications for the field of accuracy medication, which plans to convey customized and designated treatments in view of a singular's novel hereditary cosmetics and illness attributes. The revelation of this original objective might actually act as a diagram for the improvement of accuracy medication approaches in blood malignant growth treatment.

With additional examination and approval, this recently distinguished target could make ready for the advancement of inventive helpful procedures that outfit the force of accuracy medication to forestall blood disease. This might actually change the scene of blood malignant growth treatment and proposition new desire to patients who are battling with this staggering infection.

The Significance of Blood Malignant growth Exploration

Blood malignant growth is a complicated and testing illness that requires consistent examination and development to work on quiet results. Throughout the long term, broad examination endeavors have been devoted to figuring out the basic systems of blood disease and creating powerful medicines. The new disclosure of another objective in blood malignant growth research can possibly alter the field and achieve critical headways in the counteraction and treatment of this staggering illness.

Divulging the New Objective: Protein X

The notable review recognized a formerly obscure protein, we should refer to it as "Protein X", that has been viewed as profoundly communicated in blood disease cells. Protein X is accepted to assume a crucial part in the turn of events and movement of blood disease, going about as a vital controller of cancer development and endurance. Through careful trial and error and high level procedures, the examination group had the option to uncover the essential job of Protein X in blood malignant growth pathogenesis.

Sub-atomic Systems of Protein X in Blood Disease

Further examination uncovered that Protein X interfaces with different flagging pathways and sub-atomic pathways that are basic for the endurance and multiplication of blood malignant growth cells. Protein X is accepted to advance the development and endurance of disease cells by enacting specific flagging fountains and repressing others, prompting uncontrolled cell development and avoidance of modified cell passing.

Besides, the review discoveries recommend that Protein X may likewise assume a part in the improvement of medication obstruction in blood malignant growth cells, further convoluting the administration of this illness. The mind boggling sub-atomic components through which Protein X works in blood malignant growth cells are as yet being effectively explored, with progressing endeavors to disentangle its careful capabilities and connections.

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[reasonsforhope]

"People living with diabetes might have a new hope. Scientists have tested a new drug therapy in diabetic mice, and found that it boosted insulin-producing cells by 700% over three months, effectively reversing their disease.

Beta cells in the pancreas have the important job of producing insulin in response to blood sugar levels, but a hallmark of diabetes is that these cells are either destroyed or can’t produce enough insulin. The most common treatment is regular injections of insulin to manage blood sugar levels.

But a recent avenue of research has involved restoring the function of these beta cells. In some cases that’s started with stem cells being coaxed into new beta cells, which are then transplanted into patients with diabetes. Researchers behind this kind of work have described it as a “functional diabetes cure.”

Now, scientists at Mount Sinai and City of Hope have demonstrated a new breakthrough. Previous studies have mostly involved growing new beta cells in a lab dish, then transplanting them into mice or a small device in humans. But this new study has been able to grow the insulin-producing cells right there in the body, in a matter of months.

The therapy involved a combination of two drugs: one is harmine, a natural molecule found in certain plants, which works to inhibit an enzyme called DYRK1A found in beta cells. The second is a GLP1 receptor agonist. The latter is a class of diabetes drug that includes Ozempic, which is gaining attention lately for its side effect of weight loss.

The researchers tested the therapy in mouse models of type 1 and 2 diabetes. First they implanted a small amount of human beta cells into the mice, then treated them with harmine and GLP1 receptor agonists. Sure enough, the beta cells increased in number by 700% within three months of the treatment. The signs of the disease quickly reversed, and stayed that way even a month after stopping the treatment.

“This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo,” said Dr. Adolfo Garcia-Ocaña, corresponding author of the study. “This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes.”

The results are intriguing, but of course being an animal study means there’s still much more work to be done before it could find clinical use. So far, harmine alone has recently undergone a phase 1 clinical trial in humans to test its safety and tolerability, while other DYRK1A inhibitors are planned for trials in humans next year.

Perhaps most importantly, the team will soon experiment with combining beta-cell-regenerating drugs with others that modulate the immune system. Ideally this should help overcome a major hurdle: the immune system will continue attacking new beta cells as they’re produced.

The research was published in the journal Science Translational Medicine."

-via New Atlas, July 14, 2024

[dark-frosted-heart]

Roger Barel Main Route - Mad Love Chapter 22

As usual, can’t guarantee 100% accuracy on this. I’m doing this for archiving purposes and you can probably find a better translation out there

I walked around and browsed the shelves to distract myself.

However—Alfons’ words still continued to replay in my head.

~~ Flashback ~~

Alfons: If that man did not have very long to live, would you still choose to stay by his side?

(Roger…didn’t have long to live?)

Kate: …Please don’t make bad jokes.

Alfons: Didn’t you want to believe the good in me? Besides, you were with him for nearly a month. Surely you must have had some kind of idea?

(Ah…)

~~~~ Flashback within a flashback ~~~~

When we went undercover at that village led by the Spirit God.

When Roger synthesized a treatment for tetanus, he didn’t hesitate to take it himself to conduct a clinical trial.

He didn’t let Liam be the test subject.

~~~~ End flashback within a flashback ~~~~

Roger’s ambition was to “get rid of curses of the Cursed”.

(A person like that wouldn’t devalue his own life)

(...Unless it’s for the sake of researching how to “get rid of curses of the Cursed”?)

While reading through the various research materials so that I was ready to be Roger’s assistant, I remembered coming across the words “drug resistance”.

Kate: Could it be…because Roger’s been using himself as a test subject, he’s…

Alfons: I honestly couldn’t care less whether that man lives or dies. However, there was a night when I gave into a bit of temptation and asked for the truth—

~~~~ Flashback within a flashback ~~~~

Alfons: Are you dying?

Roger: Where’d that come from? Bit of a heavy conversation to have over drinks.

Alfons: When have we ever had a friendly, peaceful conversation?

Roger: Haha, guess you’re right. Still…How’d you know?

There wasn’t even a trace of death within that bright laugh.

Alfons: We’ve known each other for a long time. Regrettably.

Roger: …

Roger silently set his glass of beer down.

Roger: I’m dying—’Cause I’ve been repeatedly conducting experiments on myself.

Alfons: I see. Though you’re surrounded by Cursed Ones now, In the past, it wasn’t easy to find them.

Roger: Yeah. Back then, you were the only one I knew. I’m the furthest from the self-sacrificing type. I just had no choice but to borrow my own lifespan for my ambitions. That’s all.

~~~~ End flashback within a flashback ~~~~

Alfons: —As that person said, “that’s all.”

(...That’s all?)

Kate: How can he just say “that’s all”...when it’s his life he’s talking about.

Alfons: That’s all there is to it isn’t there? 

Kate: Huh…?

Alfons: We Crown are villains that exist in the dark night. We have all since given up living normal lives and being happy. We are all ready to die before our time. It is a part of our daily life.

Alfons’ eyes are as calm as a lake deep within a forest.

Alfons: Nevertheless, getting involved in something without being aware of the full extent isn’t clever, now is it?

But when he’s worried for me, his eyes wavered.

Kate: …Alfons

Alfons: That man is a terrible, egoistic scumbag who only thinks of himself. If you want to become a widow, then do as you like. At this rate, why not just stay close? While you’re in tears, I can appear before you and show you illusions of Roger.

~~ End flashback ~~

Kate: …I don’t want illusions.

The words I wasn’t able to say back then disappeared into the night air.

After some time in the forest of books, my troubled heart finally settled down.

(Just now I was too upset to think clearly, but…)

(Like Alfons said…“that’s all”)

Roger had considered whether to prioritize his ambitions or lifespan and in the end, chose his ambitions.

Besides, being a part of Crown meant that your life was always in danger and you never knew when you would lose your life.

(I’m well aware of that, but…)

I’ve been arrogant and stupid.

—That’s why it felt like Roger would always be by my side.

(Had Alfons not told me, I would never have known)

Roger and I weren’t just Fairytale Keeper and Crown anymore.

I love Roger and he…told me that he loves me too.

(I wonder…What will Roger do with our relationship)

As I pondered over it, a memory popped into my head.

(Ah…)

~~ Flashback ~~

Roger: Then I’ll give you one final trial on the robin growth map. If you can clear it, you’ll be my lover.

Kate: …Huh? One final trial? Why? You…like me, don’t you?

Roger: I do, but that’s unrelated. I’m the type to train my dogs properly. I don’t spoil them just ‘cause we’re family.

~~ End flashback ~~

(...Could it be that)

(—For my final trial, you’re going to let me go?)

(No, I can’t just say that’s what’s he’s doing…but what if—)

There was no point in guessing, but I couldn’t help but imagine the worst.

(If Roger does want to separate…perhaps it’s better to agree to it)

I’d feign ignorance, fail the final trial, and leave my position as Fairytale Keeper.

I’d leave Crown and Roger, and never see him again.

And then I’d return to my normal, peaceful life.

Kate: It will be painful at first, but…with time…I’ll get used to not having Roger.

I couldn’t help this feeling of weakness.

Ale: …Woof. Arf arf!

Kate: Huh, Ale?

Ale: Arf!

Ale suddenly broke into a run.

It was just my luck that the door wasn't closed properly so with a short paw, he pushed it open and ran out.

Kate: Where are you going, Ale? Wait…!

--

Kate: Ale, hey Ale!

Ale: Arf arf!

(...I understood)

(Whenever Ale suddenly ran off like that, it’s because—)

He wanted to tell me something.

Then—I guess it’s time to see Roger.

--

I could’ve reached out and grabbed that small body of his, but I just followed Ale.

We ran through the palace, through the dense first, through the halls of Crown Castle until—

Roger’s voice: Woah! What’s up, Ale? You’re pretty energetic today!

Ale ran into the lab and jumped on Roger.

When he saw me following after, his amber eyes grew wide.

Roger: Kate!

Seeing that wild smile made my heart pound.

That innocent, carefree, child-like smile was enough to steal my heart.

Roger: I was just thinking about calling for you.

Kate: Oh…Um

(The fact that he was waiting for me means…)

Kate: Is something the matter?

Roger: Yeah, the best thing. Take a look at this research material.

What Roger handed to me looked quite old and faded.

I took a closer look at what was written…

Kate: “Research Material on the Cursed. Researcher, Alexander Taylor” It’s Alec!

Roger: It’s definitely his handwriting and research.

Kate: But…I thought the police had confiscated all of Alec’s research…

(So why is this here?)

Roger: You know Jude’s company? Seemed like some guys from Gracefield Royal Hospital tried to get in the way. So Jude decided to go pay the Royal Hospital a little visit.

Kate: He’s as vindictive and proactive as ever…

Roger: So then he found this piece of research material in a lab.

Kate: The lab where the Privy Council and doctors were doing their research before they got poisoned… If Alec’s research was found there, then that means…!

I had my answer.

Roger’s nod confirmed my thoughts.

Roger: That’s right. Those guys combined mine and Alec’s research materials to synthesize a drug that would get rid of curses.

Kate: I thought so! Then with this research material,

Roger: We can make an antidote.

Kate: What a relief. We did it, Roger.

Roger beamed at me and when he pulled me into a hug, I was overwhelmed with joy.

Roger: …Thanks for being here with me for this, Kate.

Return his hug +4 +4

Spontaneous kiss

Pull away in embarrassment

Heart filled with joy, I returned Roger’s hug.

I squeezed him tight. Roger then picked me up and spun me around.

Roger: Haha, we did it Kate!

(...I can hear Roger’s heart beating when I’m in his arms)

It was too precious to stand.

(Ah…I’ve been an idiot)

(Why did I even think I could leave him for even a moment?)

(My heart’s already been stolen and dyed)

We’re adults…so it wasn’t like we couldn’t live without the other.

No matter how much it hurt, how painful it was, how long is spent wandering around in nothingness.

This was my egoism.

(I want to be with Roger)

(Until the moment his heart stops beating)

It appeared that spending time with Roger had turned me into an egoist.

(...But before I can do that, there are some things I need to do first)

You can’t get what you want by just staring wistfully.

Kate: Roger. After finishing the antidote and you’ve condemned them… I have something I need to talk to you about.

Amber eyes watched me intently…before they softened with understanding.

—That night, we finished making the antidote.

From then on began the endless series of condemnation of evil. 

--

Privy Council Lord: …Haaa…Urk…Why are you here? 

Royal Hospital doctor: …Ugh. They’re here to mock us…

The Privy Council and doctors that Victor and William had locked up were still in their cells.

They had all been poisoned, their central nervous system damaged. They groaned and breathed heavily like beasts.

While looking down at them crawling on the cold floor, Roger and I unlocked their cell and entered.

Roger: Oh, that’s harsh. We even lost sleep and skipped meals to make an antidote.

Privy Council Lord: …An antidote?

Kate: The test tubes in this medicine box contain an antidote that Roger made. The efficacy has already been tested. You’ll feel relief within 30 minutes of taking it.

At that moment, the color of their eyes changed. And not just in a figurative sense either.

Royal Hospital doctor: …Haaa….With this…I’m saved.

Royal Hospital doctor: We were forced to do this research because these people ordered us to!

Royal Hospital doctor: Give us innocent doctors the antidote.

They crawled toward us, ignoring the pain from their broken nails as they clawed at the stone floor.

Choked groans and shining eyes…

Them desperately grabbing at Roger’s legs was a strange sight to see.

Roger: …Innocent?

Royal Hospital doctor: We may have done a lot of bad. But it was all for the sake of our country!

Royal Hospital doctor: With our numerous experiments, we doctors will advance medicine in Britain. It will certainly make our country prosper. You’re a doctor too, aren’t you? Surely you understand our feelings.

They try to butter him up, only for their own sakes.

With their lives in his hands, Roger—

Roger: Yeah, I get it.

With eyes full of pity…

Roger: —I get that you’re all a bunch of damn hypocrites.

[mindblowingscience]

A human-made antibody successfully prevented organ rejection when tested in primates that had undergone a kidney transplant, report researchers. The finding clears the way for the new monoclonal antibody to move forward in human clinical trials. Results of the study appear in the journal Science Translational Medicine. “Current medications to prevent organ rejection are good overall, but they have a lot of side effects,” says lead author Imran J. Anwar, a surgical research fellow in Duke University��s department of surgery. “These therapies suppress the immune system, putting patients at risk of infections and organ damage, and many cause non-immune complications such as diabetes and high blood pressure. “The push over the last 30 to 40 years has been to develop new, less toxic drugs,” Anwar says. “We are hopeful this antibody moves us closer to that goal.”

Continue Reading.

[laxmiree]

[CN] MLQC Lucien’s Rumors & Secrets – Season 2: Threshold (阈值)

⚠️ SPOILER ALERT!! ⚠️

This post contains a detailed spoiler for an R&S that has not been released in EN yet! Feel free to notify me if there are any mistakes in the translation~

Lucien followed the doctor's pointing finger to a line on the report— a small amount of abnormal PTEN gene sequence in the cells.

“Although the abnormal PTEN is only a small amount, irreversible cancer development may occur if your deterioration continues."

"The speed of deterioration is closely related to the frequency of Evol use, so it is recommended to reduce the usage of Evol as much as possible in the future.”

Lucien nodded occasionally, his heart not experiencing significant fluctuations. This day had been expected, and it had arrived as scheduled.

[T/N] It’s advised to read S2 chapter 45 first because this R&S sets between S2 chapter 45 and chapter 51 timeline-wise. I usually translated the main story first but translating this first makes more sense chronologically AND will provide extra pain for S2 chapter 51~

ALSO, after reading the R&S please head up to S2 Chapter 51, the pain is more complete with the main story~

[Chapter 1]

“Professor Lucien, the latest clinical trial report results are out, and they are still not very promising.”

This not-so-good news didn't come as a surprise to Lucien. He nodded and said, “Ah He, you've worked hard these past few days. Take a good rest over the weekend, and next week, we'll come back to discuss improvement strategies.”

“But we've already improved almost every aspect,” Ah He swallowed the words on the tip of his tongue and glanced at Lucien's composed profile. “In addition, two new deteriorating patients have signed the drug trial observation agreement. Here are the records.”

Lucien took the file and opened it, quickly scanning the text inside.

“The first patient is forty-two years old, an Evolver with superhuman vision. Diagnosed with glaucoma seven years ago, their vision started deteriorating significantly six months ago. After genetic screening, it was confirmed that the condition was caused by deterioration.”

As he turned to the next page, Lucien's gaze froze.

....The second patient is a Water-type Evolver, but the symptoms of deterioration are widespread malignant lymphoma.

“Based on previous cases, the direction of Evolver deterioration should be closely related to their own Evol attribute,” Ah He showed a puzzled expression, “and this patient's symptoms were an exception, with a more unstable rate of deterioration than ordinary patients. Perhaps this could be a discovery in the study of deterioration illness.”

Lucien glanced at the photos of the young man again. Although his impression wasn't deep, he quickly found this person in his memory – he had appeared in one of BS's Evol modification experiments many years ago.

“The individual cases don't have high reference value. We need to expand the sample group and continue to watch for similar cases of deterioration.”

“Understood, Professor.”

Back in his office, Lucien spread out the two reports in front of him. The deterioration index line graph in the first report steadily increased over time like most of the patient data he had seen. However, the line graph in the second report suddenly spiked at a certain point in time after a long period of stability.

Lucien unlocked his computer screen, and a medical report appeared on the screen. The diagnosis result, highlighted in red and bolded was glaring and prominent – “Gene Deterioration Detected.”

The deterioration level line graph in the report progressed steadily, almost identical to the first half of the line graph of the second patient on the desktop.

As the report page slowly scrolled upward, a profile picture gradually appeared in the upper right corner.

He glanced indifferently at his own face in the photo, closed the document, and leaned back in his office chair, closing his eyes to rest.

The heart within his chest cavity beat steadily, just like every other day, strong and composed. No changes appeared to have occurred, yet hidden beneath the surface, there seemed to be an undercurrent that was difficult to detect, waiting for an opportunity to stir things up.

His brief reverie was interrupted by the ringing of his phone.

“Hello, Mr. Lucien. Your latest lab test report is ready. Please come to the laboratory during business hours to collect it.”

[If you remember- In S2 chapter chapter 31-1 Lucien mentioned that his situation regarding blood disease is unique. From this R&S I guess what he means by unique situation is that his deterioration wasn't REALLY bad until he started to overuse evol, mainly for the sake of protecting MC. This evol overuse will get worse in S2 chapter 51 :D]

-

[Chapter 2]

“Have you experienced any discomfort in your body recently? Have you used Evol?”

“Everything has been normal. I've used Evol a few times, but not excessively,” Lucien quickly counted the number of times he had used Evol in his mind over the past month.

It was around seven or eight times, within a manageable range.

The doctor pushed the report in front of Lucien with a serious expression. “Your deterioration had been well-controlled previously, but this time, there are changes in various indicators. Platelet count has decreased, and there might be a slight impact on your clotting function. Additionally—”

Lucien followed the doctor's pointing finger to a line on the report— a small amount of abnormal PTEN gene sequence in the cells.*

“Although the abnormal PTEN is only a small amount, irreversible cancer development may occur if your deterioration continues. The speed of deterioration is closely related to the frequency of Evol use, so it is recommended to reduce the usage of Evol as much as possible in the future.”

Lucien nodded occasionally, his heart not experiencing significant fluctuations. This day had been expected, and it had arrived as scheduled.

(T/N: PTEN is a tumor suppressor gene that plays a critical role in regulating cell growth and preventing the formation of tumors. And since his platelet count is decreasing, it'll be HARD to stop his bleeding)

The hospital wasn't far from the bioresearch institute, and he reached his office right on time for work. As usual, he opened his computer and pulled up the latest clinical reports on anti-deterioration medications that he had just received in his email.

Among the patients participating in the clinical trials, 42% showed some level of deterioration control after taking the medication, with 8% experiencing particularly positive results. However, for nearly 58% of the remaining patients,...

The research on the medication had been ongoing for nearly a year, yet it still couldn't achieve the expected efficacy. Lucien carefully examined the data on the screen, tapping his fingertips lightly on the desk.

Incomplete Evol genes could lead to abnormalities in the human body, but why would the highly praised “evolutionary” Evol genes lead to such destructive deterioration?

Could it be that Evol eliminates those who cannot withstand its power? Or is the deterioration of Evolvers, to some extent, a part of the world's evolutionary process?

Some vague thoughts raced through his mind, and Lucien allowed them to linger, making a mental note as he continued to focus on the report in front of him.

As the sunlight gradually intensified, shifting towards the other side of the skyline, Lucien took a deep breath, preparing to take a short break.

Just as he closed his eyes, his ears picked up three quick knocks on the door. The third knock was slightly heavier, a habit unique to Pete.

“Come in.”

The door swung open, and Pete briskly walked up to the desk, handing over a stack of research reports.

“Professor, there have been new developments in the experiment data regarding the neuronal position for maintaining neuron function. Detailed results and data are all written in the report. We can start the next phase of experiments tomorrow.”

Lucien quickly glanced at the data and results on the report, and he smiled.

“The results are even better and faster than I had imagined. After work, you can take everyone out to celebrate. Consider it a team-building event, and the institute will reimburse it.”

“You should join us too; the rapid progress of the experiment owes much to the insights you've given us. Everyone wants to thank you.”

Lucien paused for a moment, then continued nonchalantly, “Make a reservation for one more seat, and thank you for your hard work.”

“Sure thing! I'll go inform the others right away.”

After Pete left the office, Lucien shifted his gaze to the dormant screen. He saw his own blurry silhouette, and the lingering smile on his lips confirmed his fleeting good mood.

Maybe... He agreed a bit too quickly just now.

Lucien shook his mouse, and a dense data set appeared on the screen again. It was an observation report from NW on unusual energy fluctuations within Loveland City, as well as the strange phenomena they had generated. This report piqued his interest, and according to the original plan, he should have worked late to finish this research tonight.

However, occasionally participating in such activities could be beneficial for teamwork. Lucien hesitated for only three seconds before saving the document and shutting down the computer.

-

[Chapter 3]

“Swoosh-”

The clear water rinsed away the remnants of liquid in the test tube, and a momentary daydream washed over his relaxed mind. The scene from this morning when he left home reappeared before his eyes.

As Lucien opened his door, the opposite door also swung open, and a girl rushed out with a box of milk in hand. Her hair was slightly disheveled, clearly a result of rushing and not having time to tidy up for work.

He smiled faintly, but strangely, she seemed completely unaware of his presence and focused on her phone, anxiously waiting for the elevator.

In the next moment, the girl's figure seemed to “disappear,” but the elevator remained on the top floor, not descending.

He was briefly taken aback but quickly realized that this was likely the phenomenon caused by the energy fluctuations he had recently seen in the NW observation report on Loveland City. The unknown energy disturbance in the vicinity had created a “rift” in spacetime, and the girl was merely a projected illusion.

The sound of glass clinking brought Lucien back to reality, and he noticed that the test tube in his hand had bumped into the beaker.

“Professor, are you feeling a bit tired? Maybe I should take care of this for you,”

Lucien smiled in response to Pete's concern and began placing the lab equipment into the washing machine. “No need, nothing is pressing right now. I'll consider organizing equipment as a form of rest.”

Although the work on hand was never-ending, under her supervision, he had already learned to carve out some breathing space for himself.

During moments of complete relaxation, unexpected thoughts often diverged in his mind, which brought him happiness. However, lately, whenever he tried to clear his mind, the girl's image and voice would involuntarily “visit” him.

Seeing the slight, involuntary upward curve of his lips, Pete gave him a knowing look and half-jokingly asked, “Professor, are you going on a date later?”

“She's been quite busy lately.” Lucien subtly concealed the thoughts he had inadvertently revealed just now and continued, “Pete, have you chosen a topic for your thesis?”

“It's almost ready. This time, I plan to research 'Using Evol Energy to Stimulate Brain Cells for Alzheimer's Disease Treatment.' I'll put together a formal document for you to review.”

“I remember you were interested in brain memory restoration and extraction before, and you had many intriguing ideas. Are you not planning to explore that area this time?”

“Afterward, I reconsidered. There's more literature available on Alzheimer's disease, and the current market demand is higher. It seems like a more prudent choice.”

Lucien's gaze shifted slightly, not missing the hint of regret that flashed in Pete's eyes.

“I actually think that if it's a topic that interests you, you should give it a try,” Lucien blurted out his most direct thought, receiving a surprised look from Pete.

“What everyone else is doing may be the safer choice, but it's not necessarily the best choice.”

“Uncharted territory doesn't always equate to a dead end; it's just that, in many cases, people tend to instinctively seek the safer path.”

“But in research, the most valuable quality is the persistence to explore and seek knowledge.”

On the way back home, Lucien continued to contemplate the events of the afternoon.

In the realm of scientific research, aiming for safety was not necessarily a mistake; it often led to higher success rates. So, when he made that suggestion, it wasn't solely from an objective standpoint but also a personal desire that the researchers he had mentored could challenge more difficult domains.

Suddenly, a faintly familiar sweet fragrance wafted to his nostrils. He followed the scent and turned to see her favorite cream puff shop.

“Maybe I should buy one and give it a try.”

A few minutes later, Lucien sat on a park bench holding a freshly baked cream puff. He wasn't particularly fond of cream puffs, but the idea that had occurred to him a moment ago had struck without warning. Before he could contemplate the reason behind this thought, his body had already acted on it.

The cream puff, still warm inside its paper bag, emitted a subtle fragrance. He took a gentle bite, the crispy outer shell giving way to the creamy filling, creating a delicate taste on his tongue.

This cream puff wasn't overly sweet and the sweetness that could be detected was minimal.

This subtle sweetness triggered dopamine, and an inexplicable sensation gradually spread from his chest to his limbs. It seemed like his brain had received this pleasurable signal, making him feel considerably more relaxed.

So, this was what she meant by the happiness brought by sweets.

He slowly savored each bite of the cream puff.

Lucien knew that an irreversible change had occurred within himself.

[This behavior of trying new things and impulsively doing something feels like 'my time in this world won't be too long anyway' :""]

-

[Chapter 4]

Inside the research lab, the mechanical hum of instruments droned on rhythmically, and the stark white lights cast a cold silver gleam on the metal plaques with “NW” written on them.

“Blood pressure stable, sinus rhythm normal, no adverse reactions.”

“According to the drug's suggestions, he will act according to our instructions after leaving this lab.”

Lucien glanced through the glass at the person lying on the observation room bed.

“Conduct thorough post-experiment observations, don't overlook any minor irregularities.”

“Alright. Also, Professor Lucien, your ETL-147* drug trial application has been approved, and you need to sign the liability waiver.” The lab technician handed the paperwork to Lucien, looking somewhat hesitant.

“Are you sure you want to personally participate in the drug trial? Although we've conducted preliminary human trials, we haven't done large-scale clinical trials yet, and there are certain risks involved.”

Lucien quickly signed his name. “Trying it myself is the only way to discover areas that may need improvement.”

[I was right about Lucien experimenting on himself with that drug :"D. Anyway, ETL-147 is the same drug from S2 chapter 45]

“Once you've decided, you'll need to receive the injection within the confines of NW with someone present, as per the regulations.”

“Then let's do it now.”

Declining the researcher's offer to assist, Lucien skillfully rolled up his sleeve and disinfected the area. As he watched the liquid in the syringe decrease, he blinked slightly, concealing some contemplation.

“You can go ahead, I'll observe here for half an hour. If there are any issues, I'll reach out to you.”

He watched the researcher leave and then lowered his gaze to his arm, which had a tourniquet in place. Testing the drug on himself wasn't solely for drug research. He could increasingly feel that something was changing within him, hiding and flowing in the gaps of his nerves, elusive and slipping out of his control.

That's why he needed insurance.

He didn't wait for half an hour and left the observation room. The solemn and cold corridor echoed only with the light sound of his footsteps. Each corner had a circular surveillance device with a flashing red indicator light, watching his unhurried steps. He paid little attention to them as he arrived at Archive Room 8.

“Authentication personnel, Lucien. Authorization Level: Three.”

With a beep of an electronic tone, the door to the archive opened for him.

Rows of gray filing cabinets stood in order. He walked deeper into the room, stopping at the second-to-last row. From one of the shelves, he pulled out a file box.

“Blood Disorders and Deterioration Case Files.”

He opened the lid and browsed through the materials inside. During his involvement in the research of anti-blood disorder drugs at NW, Lucien had seen most of these files. As he turned a page, his slender fingers paused.

“Code **, deterioration level reached as high as 95%, reversed deterioration after ** experiment, and after a period of observation, full recovery of human functions, deterioration level reduced to 7%. Detailed information requires special-level clearance to access.”

Looking at the encrypted data, Lucien's lips curved upward without a hint of a smile. He returned the file box to its original place.

It seemed there were quite a few deals he could make here.

-

[Chapter 5]

“To see a world in a grain of sand, and a heaven in a wild flower. Hold Infinity in the palm of your hand, and eternity in an hour. A truth that’s told with bad intent, beats all the lies you can invent...”

(T/N: From the poem Auguries of Innocence written by William Blake. For Blake there's such thing as white lies. Because 'A truth that's told with bad intent' is worse than any lie, because some lies can be well-intentioned)

Under the camphor tree swayed by the autumn breeze, he softly recited verses from the book. Sensing the girl in his arms gradually breathing deeper, he closed the book and gently brushed a strand of hair from the corner of her eye.

In the warm breeze, Lucien slowly opened his eyes, gazing at the familiar cold white ceiling of his office, feeling a slight sense of déjà vu.

This was the fourth time in these seven days that he had dreamt of her.

Since the deterioration, he had hardly experienced any physical discomfort. However, the frequency of thinking about her had increased significantly. He didn't resist this feeling; in fact, every time he thought of her unintentionally, the neurons in his brain transmitted a sense of pleasure to every cell.

He ran his fingers over his knuckles; the wounds from his struggle with GR had scabbed over, but she still applied bandages to them cautiously. Lucien pressed his temple to clear his mind a bit, then returned to his desk, opened a document, and entered the latest date.

“Dreamt of her in a dream, vivid memory of dream content, but ruled out as a recollection.”

After recording this, he opened his email.

This was the latest data on energy fluctuations within Loveland City. On the vast map of Loveland City, there were numerous unusual energy fluctuations. After comparing the fluctuation charts for each period, he noticed the locations where fluctuations were concentrated at different times.

Approximately 36 days ago at around 18:39, Central Park. He and the girl had gone to the night market in the park after work, and they had dinner at a street food stall.

Approximately 27 days ago at around 12:25, the Life Sciences Institute. She came to bring him lunch and, in passing, asked him about the topic for the next program.

15 days ago at 23:48, his apartment. To celebrate the upcoming weekend, they stayed up late watching a movie and didn't return home until very late. She stood at his doorstep and bid him goodnight.

Nine days ago...

The light from the screen reflected a coldness in his pupils as he stared at the map with red markers blinking in different locations.

The center of the fluctuations, once again, was that source of power that had captivated countless people—CORE.

The more beautifully the flower bloomed, the more it attracted annoying flies.

A sudden sense of irritation welled up within him.

What would it take to keep those ill-intentioned insects away from this deeply-rooted flower?

“Snap.”

The light sound shattered the silence as the pen fell to the ground and rolled twice before coming to a stop by his feet.

That sudden absurd idea had torn away all pretense, revealing the raw instinct in its entirety.

— If she had her own path, she shouldn't be trapped by him.

— Don't restrain yourself with rationality, look at your true heart.

Perhaps that dream had already given him a hint. The scales in his heart had gradually tilted away from reason, moving in an unexpected direction.

— She withstood all the wind and rain that came her way, growing resiliently into someone he found truly remarkable. He couldn't encase her within his protective glass cover.

— Are you really don't expect it? Really don't want to possess her? Humans are inherently greedy. Indulgence is human nature.

Lucien felt as though there was a consciousness from a deeper layer detaching from his body, standing at a higher vantage point, watching with keen interest as the two voices in his mind continued their ongoing debate.

Perhaps his own deterioration graph had already started its inexorable ascent towards an unpreventable height, progressing towards the final moment that could arrive at any time.

He suddenly realized that he wasn't as averse to facing that moment as he thought. All the changes in his body were intriguing, both evolution and destruction.

Cells and genes evolved over countless years to adapt to their environment, giving birth to more complete species. However, the incompleteness of the Evol gene led to human deterioration, going in the opposite direction of evolution.

Perhaps Evol held a meaning deeper than “evolution” and “power,” a meaning that no one, including him, had yet to comprehend.

His phone vibrated suddenly, bringing the storm in his mind to an abrupt halt. The girl's name accompanied a text message that appeared before him.

“Do you have time tonight? I found a new barbecue place on Huapu Street.”

“Of course, I'll pick you up after work.”

Perhaps he shouldn't see her now; if he did, this imbalance might intensify rapidly.

But why not indulge in something that brought him happiness?

Lucien closed his eyes.

This self-observation finally introduced more significant variables.

-

NEXT STOP-> [S2 Chapter 51]

[maverick-werewolf]

Werewolf Fact #70 - Werewolves in medical history + "clinical lycanthropy"

The results of the werewolf fact poll over on my Patreon are in, and now we have this month's werewolf fact: all about werewolves in historical medical treatises of the Renaissance/Early Modern period and the term "clinical lycanthropy," as well as what all that means and how it still impacts werewolf studies and werewolf pop culture today.

This post will make use of a lot of primary sources, which I always find fun, so buckle up!

I've done several posts touching upon subjects similar to this before, you might be familiar with them, such as how werewolves in folklore are the result of a curse instead of a disease, and my two-parter on when werewolves became associated with insanity (Part 1 and Part 2 are here). You can also read a whole lot more about that topic and my arguments regarding it in my thesis, which was on werewolves, and can be found here on Amazon.com (hardback coming soon!).

However, I have never really delved in detail into a few of the actual medical treatises written during the Renaissance/Early Modern Period - in other words, primary sources - of which we have several. In this post, I will cover a few, but not all. I'm also going to make mention of a few more modern ones in regard to clinical lycanthropy, but let's start with older first...

First of all, there was a lot of discussion of "melancholy" in the 1500s in regard to werewolves. This was even referenced in the play The Duchess of Malfi (and I actually have an academic article dedicated to the discussion of the lines involving werewolves in said play). This is, of course, related to the ancient Greek theory of humors, in which the composition of the human body and health required the balance of four humors: black bile (earth), blood (air), choler (fire), and phlegm (water), each related to one of the classic elements.

Throughout the Renaissance, "wolf-madness" was attributed to a case of melancholy, or an excess of black bile. There are many examples of this. And, of course, there are also many attributions to Satan... which was not a thing at all before this time period, as before this, werewolves were even sometimes associated with Christianity (see: werewolves of Ossory, among others).

An oft-referenced source in both werewolf studies at large as well as my own works is "Admirable and Memorable Histories" by I. Goulart, from around 1607 and translated from French by Ed Grimeston; I use this source from my book A Lycanthropy Reader by Charlotte F. Otten. Please note that the language of the piece is dated, so it will read funny to modern audiences.

Goulart discusses "Licanthropes and mad-men, the which wee will consider of two sorts," not necessarily equating those suffering from "lycanthropy" as mad-men, but as those "in whom the melancholike humor doth so rule, as they imagine themselves to be transformed into Wolves." He refers to them as "counterfet Wolves" and discusses how they "runne into Church-yardes, and about graves," something not uncommonly seen in the newfangled werewolf sources of the 1600s onward but not commonplace in werewolf legends of previous time periods.

Goulart also discusses men "tormented with an evill spirit, that at a certaine season of the yeare, hee imagined himselfe to bee a ravening Wolfe," and references other elements seen only in the later werewolf trials as opposed to previous werewolf legends. I also can't help but wonder if the "certain season" element is something Curt Siodmak saw and carried over into the original werewolf in The Wolf Man turning during a particular season (when wolfsbane blooms in autumn)...

Anyway, another of Goulart's sources is Job Fincel in 1541, who describes werewolves in ways we see around a lot when googling and finding garbage on the internet but not so much in legends previously, such as how those afflicted with the "disease" of believing themselves to become a wolf (but not actually turning into one) "are pale, their eyes are hollow, and they see ill, their tongue is drye, they are much altered, and are without much spittle in the mouth." This is consistent with particular illnesses rather than anything seen in werewolf legends, as these are not the people who truly become wolves, only those who believe that they do - and Goulart was still drawing lines between those with hallucinations, those who actually change shape, and those who are werewolves by other means. For example, Goulart also discusses the idea of people whose souls fly from their own bodies and enter into the forms of wolves instead.

There are other examples that discuss these same topics, of course, including but not at all limited to "Diseases of the Mind" by Robert Burton and "A Treatise" by Robert Bayfield, both of which are also featured in A Lycanthropy Reader, and there are plenty of others in assorted other werewolf studies publications.

Now, in addition to these older examples, we also have much more recent medical studies regarding what is known in modernity as "clinical lycanthropy."

Here's a fun fact: the term "lycanthropy" wasn't ever used in antiquity to refer to werewolf legends. It was created by the medical profession in the 1500s to refer specifically to a form of madness, not shapeshifting. It referred to what was recognized as a mental illness that they called lycanthropy: someone believing that they turned into a wolf, not to someone actually turning into a wolf (as in, not referring to the legends in which this happened).

Today, we call this "clinical lycanthropy," because the term "lycanthropy" was basically taken by werewolf media and werewolf studies and retroactively applied to werewolf legends. But the term "lycanthropy" was never actually used in said legends.

The term "lycanthropy" to refer to a "werewolf disease" is just another way in which medical studies and Renaissance writings turned werewolf legends into a "werewolf disease" instead of a magical curse, as it always used to be.

Now, of course, the medical world doesn't really recognize "clinical lycanthropy" anymore. It's considered to be a part of other mental conditions, the result of drug-induced hallucinations, or something entirely different. Several cases were attributed to schizophrenia instead, for example. So the term "clinical lycanthropy" in itself is all but outdated.

I won't be including or directly quoting from the case reports from the 1970s in this discussion, as this post is already enormous and, frankly, the case reports are not things that could be easily discussed in today's environment, as the language in the reports would certainly be considered offensive today, and that's not something I want to navigate. So I won't get into all that. They're out there if you want to read them, but I won't bother breaking them down here.

There are also certainly other examples of medical history relating to werewolves and werewolf legends, but I'll save all that for the werewolf facts book or another publication of mine!

Medical treatises are just another example from the Renaissance (and for quite a while after, into at least the 1800s and even early 1900s) of trying to rationalize and find "scientific explanations" for all manner of folklore and mythology. This also resulted in a considerable amount of condemnation for those who still believed in this sort of thing, as well as those who believed themselves to be experiencing it. As mentioned in some of my other werewolf facts, this didn't always include punishment (many victims of clinical lycanthropy at the time were actually well taken care of), but it did include things like being locked away from society for being declared insane. And, of course, if the victim in question was not a victim but a perpetrator, then it would result in a trial and punishment - and often execution. However, this was much more likely to happen to witches rather than werewolves. Just another way in which the trial of Peter Stubbe were very obviously witch/sorcerer trials and had nothing to do with werewolves at all.

Now, of course, you'll also recognize that a lot of the things you see in the treatises I used as examples don't follow up with many or even any werewolf legends you're very familiar with. Things were getting a bit weird at this point in history in regard to folklore and the like, and the reaching for rationalizing something like a person turning into a wolf or wolf-monster of any sort certainly resulted in some wild connections.

While this is far from the werewolf legends that personally fascinate me most, they are an important part of werewolf studies - hugely so. In fact, they're often discussed more than almost anything else, because unfortunately werewolf scholars are overly obsessed with later time periods that I personally find less fun and interesting than the Middle Ages and ancient times. But, hey, I love all of it.

Until next time!

And remember, if you want to vote on the next werewolf or vampire or other folklore fact, be sure to check out my Patreon. Thanks for reading!

( If you like my werewolf blog, be sure to follow me here and check out my other stuff!

Patreon — Personal Website (new and improved! Great starting point!)  — Wulfgard — Werewolf Fact Masterlist — Twitter — Vampire Fact Masterlist )

[darkmaga-retard]

"It's a massacre!" "...by the beginning of next month, Japan has the potential to trigger a worldwide disaster..."

Aussie17

Sep 20, 2024

On September 12, 2024, Japanese Member of Parliament Ryuhei Kawada led a highly charged emergency press conference in Japan, voicing deep skepticism about the country's upcoming launch of mRNA replicon vaccines, or what some call self-amplifying mRNA vaccines. The event set off alarm bells among critics of government policies, accusing authorities of prioritizing pharmaceutical profits over public health.

What are mRNA Replicon Vaccines?

As you know, mRNA COVID vaccines, like those developed by Pfizer and Moderna for COVID-19, use a small piece of genetic code (mRNA) to instruct your cells to produce a piece of the virus known as the spike protein.

On the other hand, self-amplifying mRNA vaccines, or replicon vaccines, represent a more advanced version where the mRNA not only instructs your cells to produce the spike protein but also makes copies of itself (yay! more mRNA…) once inside the cells.

ARCT-154, scheduled to be administered to the population in October 2024, is a self-amplifying mRNA COVID-19 vaccine from the dynamic duo of Arcturus Therapeutics and Duke-NUS Medical School in Singapore. In Japan, Arcturus Therapeutics found an ally in CSL Seqirus for crafting and distributing their vaccines through a local pharma company called Meiji Seika Pharma.

Arcturus Therapeutics is a biotech company located in San Diego, California, established in 2013. Just like Moderna, which didn't release any products to the market until their mRNA experimental COVID vaccine, Arcturus also hasn't launched any medical products yet, and their self-amplifying mRNA vaccine will be their first.

Arcturus was formed through a merger with Alcobra Pharma, an Israeli pharmaceutical company, after Alcobra faced difficulties during clinical trials, which led to their merger with Arcturus Therapeutics in 2017. Interestingly, Alcobra translates to “The Cobra.” You have to wonder who decided that naming their pharma company after a snake was a good idea. At this point, my eyes are rolling all the way to the back of my head, so I will stop talking about the company’s history here.

[nerdgirlnarrates]

It's battle of the macrolides for this matchup! Both these meds work by binding the 50S subunit of ribosomes, preventing translation. So who's better?

Azithromycin: The most prescribed anti-microbial in the US. It's a derivative of erythromycin with improved gram negative coverage as well as gram positive and atypicals coverage. Azithromycin's main game is the lungs, where it's useful for almost every pneumonia as well as COPD exacerbations; it's even used off-label as post-transplant prophylaxis for bronchiolitis obliterans. It is also considered to be safer than erythromycin with fewer adverse cardiac effects.

Erythromycin: Erythromycin has some unique applications, such as prophylaxis for gonococcal ophthalmia neonatorum, for which it is the only FDA-approved drug. However, its efficacy in this role has been called into question recently, with some--like the Canadian Paediatric Society--calling for a shift to maternal screening instead. Another unique application is as a treatment for gastroparesis. Though it's far from first line (and the American College of Gastroenterologists 2023 clinical guidelines for gastroparesis treatment don't even recommend it), it's been used off-label for gastroparesis since the 1990s. It was the first macrolide demonstrated to be a motilin receptor agonist, and so it became a favored alternative to metoclopramide. There are no randomized trials as of yet directly comparing the efficacy of azithromycin and erythromycin for gastroparesis, and so erythromycin remains the favorite by default. Unfortunately, it is more likely to prolong the QT interval than azithromycin.

P.S. for more fun, check out this paper on 10 controversies in gastroparesis

Vote for the best antibiotic

[abybweisse]

how do you think the Undertaker will go about these soul transplants? Unlike blood, souls are much more abstract in nature and can't just be (if I may put it to bluntly) be sucked out of someones body and pumped into someone else. But regardless, his plan is doomed to fail and I just hope that he's not gonna die in the end :(

⚠️ Long post ⚠️

Soul transplant "surgery"

It would definitely be more surgical-like than sucking it out and pumping it in. Less like blood transfusions and liposuction... and more like an organ transplant.

To humans, a soul would be ethereal, but to demons and reapers it's likely something they can hold, just about as easily as a kidney or heart. Maybe not quite that physically tangible but nearly. How else would reapers be able to collect them and demons be able to eat them?

And why else would Jane, Heathfield, and that matron at F. O. L. talk about making souls match, sometimes even referring to their shapes?

I think of souls in the Kuroverse being somewhat moldable but only to an extent. In Jujutsu Kaisen, the curse Mahito doesn't seem to be able to create souls, but he can definitely manipulate/reshape souls; when he changes the shape of a soul, it actually changes the shape of whatever body it's in. If he is injured, instead of healing himself, he just preserves or reshapes his own soul to fix the injury; he can even replace lost limbs this way.

In the Kuroverse, reapers cannot make souls, either. Reapers don't even have Mahito's soul-shaping abilities. That's why Undertaker has this orphanage running "clinical trials". They start out with children because they are less set in their ways; they are more moldable. First, they are separated into four classes, based on blood type. That's the first level of compatibility.

They also take those "aptitude" tests about favorite animals, foods, etc, but choosing the "wrong" answers on those tests doesn't get you placed in another class, since class is ultimately based on blood type. What they do is force kids who have the blood type but lack the same preferences to get used to those things that are expected of their "aptitude". Some of them never fit the mold:

Ginny (Corgi) still didn't particularly like horses.

Nick (Pom) wants to play outside and prefers foods served to the other classes.

Daniel (Collie) can't stand wearing a dress or doing so-called "women's work".

Milly (Collie) doesn't like the food served to "her" class. (Staff refers to Milly as a girl, so Milly might otherwise fit the aptitude pretty well, unless it's a translation error.)

These students who make poor candidates end up being used for blood and possibly some organs.

The top students match not just the blood types but also the "aptitudes" of their respective star lords:

Theo probably likes being indoors, likes dogs, likes the menus for the Pomeranian class (probably prefers strawberry cake over chocolate), likes to read and play chess, etc. He's smart and charming, too.

Oliver is shy and tries to make it seem like he's not a good match, but that's only because he knows something is wrong. But he's a good cook (when he's paying attention) and his embroidery skills are top notch. He seems skilled in the martial arts they learn. He must not care too much what he wears. He likes the food that the Collies eat -- or he just doesn't complain -- and he probably adores whatever animal Layla likes best.

Artie is stubborn and might not like some aspects of being in Mastiff class, but he doesn't complain, since he thinks/thought the orphanage is/was his only chance of finding a decent job later. He probably likes whatever animal Polaris likes best. He doesn't mind hard work. He takes pride in what he does and keeps the other students in line, even if they aren't in his class.

Mabel must like horses (though that option isn't on the aptitude test), sports/athletics, and being outside. She likes whatever animal Doll likes best, possibly the weasel. She eats what's served to her class. She's friendly and outgoing.

These are the four kids most likely to be used for not just blood and organs... but also their souls. It's particularly bad that in ch204 they've all now been caught snooping around the orphanage. They officially know too much now about the place. (Gee, thanks, Emily. 🙄)

Theo was about to be fledged, but now all four top students could get "mass fledged". I hope any attempt to kill them off fails! I don't want Undertaker to use their souls for the star lords.

He might have already tried with earlier candidates that seemed to fit their aptitudes well, but they didn't work out as hoped. And he could eventually try with our earl (for real Ciel, of course). Theo might survive simply because Yana-san wants Undertaker to feel forced to combine the twins, like as some last resort.

But what would a soul transplant procedure actually look like?

That's your main question. We don't know much about the nature of souls in the Kuroverse, especially in manga canon. We just know that the anime staff for s2 let Claude steal "Ciel's" soul and keep it in a ring in a tin of tea leaves. He also traps Alois/Jim's soul in a ring. It's not explained how he does that... or how he transfers these souls back out of the rings and into bodies. We do know that the concept of soul shapes exists in s2, or at least compatibility based on similar life experiences; Claude reinforces the similarities between "Ciel" and Alois/Jim before combining both souls into one body. Again, the how isn't explained.

No telling whether Undertaker will ever explain how to transfer a soul from one body to another, but he might also use some device as a temporary vessel. A hair locket, perhaps. The new soul would need to "fit" the shaped "hole" left behind by the soul that's gone. If the fit isn't just right, the person is likely to behave erratically or maybe even become lethargic -- some sort of physical reaction that shows it's not working right. Could even be the person spouting nonsense or screaming in agony. Such reactions would suggest the person is experiencing some form of existential crisis or something, right? Struggling to separate body from soul. Worst case scenario might be the person trying to rip out the soul but in reality they just rip themselves apart. These different reactions are basically organ rejection... but against souls instead of a kidney or liver.

If the soul matches well enough, the person might start to behave pretty much the same as before they ever died, though they might develop certain quirks they didn't have before.

It would be interesting -- dreadful, but interesting -- to see our earl's soul placed into the body of real Ciel, since it's been emphasized they are mirror twins. Presumably, their souls mirror each other, too. If that's true, then our earl's soul would essentially have to be implanted backwards/faced the opposite direction. This could lead to a particularly dangerous mismatch!

When Undertaker is finally confronted again (by our earl and Sebastian, as well as by reapers), he's likely to eventually be forced to give up, if he doesn't just fight to his own death. By then, his experiments are likely to have failed, in some way. Sadly, his chances of surviving the series are pretty low. He might even end up on Othello's examination table. 😔

Truth is, what does Undertaker have left, if this all-consuming project is a major failure? Where does he go? What does he do? His doomed end is almost an inevitability, in terms of storytelling traditions....

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[biomedicatranslations]

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[cutecipher]

This tracks in my experience, microdosing "magic mushrooms" cleared my depression and pain for a few days while I had access to them (to be clear Im not recommending this as a treatment just relaying my experience)

[eleccy]

The Wright Family - AA4 Anthology Translation

Hey all, so earlier on @box-dwelling's post about Phoenix being kind to Apollo, I talked about a story in the official manga. Well, here is that story. I don't think that this story has ever been scanned and translated anywhere, whereas most of the others are floating around.

I didn't want to ruin my book, so rather than scan each page properly, I have taken pictures with my phone. Sorry for the less-than-stellar quality. Also, I translated this using Google Lens, so the translation may not be perfectly accurate but I think it's pretty good.

Naruhodo Family Members (or, The Wright Family) by Yuki Owari (Read right to left.)

p1 Trucy: Daddy, are you going to just leave the hospital without permission? Phoenix: I'm sorry, Trucy, it's because I don't have much free time. Hotti: Well, I'm glad you're feeling better. sfx: heh heh Phoenix: Yeah, but I still have stiff shoulders. It's awful. Apollo: That doesn't have anything to do with anything!! Apollo: If you're going to be discharged from the hospital, at least pack up your stuff properly.

p2 Phoenix: I'm sorry, it's because I had free time. sfx: ha ha ha Apollo: If you have free time, you can also clean it up, right?! Phoenix: Ahahaha. You've grown up, Apollo. Apollo: Even if I'm praised in that way, I'm not happy. Trucy: Oh, yeah! Apollo was amazing today! Phoenix: It seems so. Apollo: But after the trial, you went somewhere, didn't you, Mr. Wright? Phoenix: Because I had free time. Apollo: Enough!

p3 (Eldoon is harmonica… ing) Trucy: Well then! Trucy: To celebrate Papa's discharge from the hospital and as a thank-you for finding my panties, it's the Mr. Hat special! Phoenix: Ah, yes, pants, Trucy's pants. Apollo: Please don't say that. Apollo: Oh… Trucy: Speaking of pants, don't forget these, too. (holds up Little Plum's bloomers) Apollo: That's enough!!

p4 Trucy: When Papa was in the hospital, it seems there was a strange phenomenon at Hickfield Clinic. Apollo: Strange phenomenon? Trucy: Midnight, as the inpatients are sleeping, it seems that mysterious noises are being heard. Apollo: What… what noise… Phoenix: Huh, I didn't know that. Trucy: A nurse on a tour… as they were making their rounds, from a hospital room…

p5 Trucy: The sound of the piano echoes slowly… Phoenix: Ah, me? Apollo: Please, be quiet when you stay in the hospital! Phoenix: It's because I had free time. Apollo: Isn't that all there is to it?? Trucy: Apparently, it has now become one of the Seven Wonders! Papa is a big success! Phoenix: It's an honor, ahahaha. Apollo: This kid is totally… Trucy: I was so moved today, by the Red Fox (Kitaki) family…

p6 Apollo: Me too… Trucy? Phoenix: You must be tired from all sorts of things. Phoenix: Because it seems like ever since you arrived, she's been moving around happily. Apollo: I'm tired, too. Phoenix: Thank you for your help. I was able to recuperate at a slower pace in the hospital. Phoenix: So even if I'm away again, you and Trucy will be fine. Apollo: (smiling) Such irresponsible…

p7 Apollo: By the way… it was Detective Skye… Phoenix: Hm? Apollo: Ema called me Wright's kid today. Even I was lumped together. Phoenix: (millisecond of internal crisis, come on Phoenix, tell him the truth!) Phoenix: You're also my kid, huh? Apollo: Ah… that's right.

p8 Phoenix: Thank you for your hard work. Phoenix: It's nice to be a father surrounded by his children.

<3