#Dutasteride

[transenbyconfessions]

I’m terrified of going on t long term because of the hair loss. I’m going on topical dutasteride anyway to prevent bottom growth and torso/facial hair because I’m enban, and I’ll probably use it on my scalp as well (I don’t want to take it orally because of the effects it has on the brain when it goes fully systemic). I also have a bunch of other solutions to it (minoxidil, rosemary oil, palmetto/procerin), but I’m still so worriedly obsessed about it all the time. Hopefully hair loss stuff will improve a lot in the next few decades, but my anxiety isn’t taking any kind of soothing right now

Submitted June 20, 2023

[salternator]

Hey! I saw you comment you were on DHT blockers, mainly to stop hair loss but keep voice/muscle changes. If you're okay to talk about it, are there other benefits/effects that you know about?

Yup! I'll write out what I've read up on for my own purposes. Standard disclaimer: I don't know what I don't know, speak to an endocrinologist if possible, get regular blood tests if you can.

The main two DHT blockers (that preventing testosterone being metabolised into DHT) are finasteride and dutasteride, with dutasteride having a stronger effect.

I used to take 1mg/day finasteride, the recommended medication and dose for hair loss prevention. However it has a short (6 hour) half-life in the body and I often forget to take it, so I switched to 1mg/3days dutasteride which remains in the body for a much longer time (several weeks half-life). This is not a recommended dosage or regimen - normal dosage is 0.5mg/day for hair loss - but is likely safe since it can be prescribed up to 5mg/day.

Potentially desirable effects of DHT blockers (compared to testosterone without DHT blockers)

Prevents head hair loss on DHT-sensitive hair follicles. For some people it can also reverse existing hair loss, though I wouldn't completely count on that.

Somewhat prevents body and facial hair from increasing. I haven't seen any evidence for reversal though.

It suppresses bottom growth.

Reduces skin oil production and thus may reduce acne.

DHT blockers likely don't affect: muscle growth, voice deepening, fat redistribution, height increase (if your bones are not fully ossified).

Side effects

DHT blockers affect fetal development, so all precautions should be taken to prevent anyone who is pregnant / trying to get pregnant from accidentally ingesting it. This means pill cutters shouldn't be shared for different medications, and you can't donate blood for as long as the DHT blocker is in your body (1 week for finasteride, 6-12 months for dutasteride).

Studies done on cis men taking DHT blockers show a potential increase in depression and lowered libido. However I don't have any information on whether the same effect applies to somebody with starting at a baseline of low testosterone and low DHT, then taking testosterone with a DHT blocker.

This systematic review is quite helpful and uses fairly understandable language.

Things I know that I don't know

The metabolism of testosterone doesn't end at DHT - DHT is then metabolised into other products, and so on. I have not looked into the downstream effects of blocking production of DHT yet, which may be significant if you are taking a near-total DHT blocker like dutasteride long-term.

I have seen many posts on bodybuilding forums (most reliable source of information /s) saying that DHT blocks the effects of estrogens by competing for estrogen receptors. As far as I can tell, DHT does not seem to bind effectively to estrogen receptors, so I somewhat doubt this claim. There is convincing evidence that DHT blockers increase the risk of gynecomastia in cis men, but I haven't yet been able to find out what the mechanism is.

I hope this long post is somewhat useful, and I'm happy to talk about other aspects of non-standard transition if you're curious.

[body-health-outlet]

Dutasteride for Hair Loss: A Comprehensive Guide

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[evergreen-femme]

i left their practice a 2/5 review and the last time i was there i ran in in a skimpy dress asking for a letter supporting my castration so maybe they blacklisted me

[homomilitia]

Girl whys my testosterone so high 😭😭😭 i only do 100 mg / 2 weeks thats normal amts.....

[hemiacosmetics]

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[peggle2speedrun]

bleh