#ELCS Lab

[digitallab001]

Bringing Global English Standards to Indian Classrooms with Language Labs

A language labs is a digital platform designed to enhance English proficiency by focusing on key skills like grammar, pronunciation, vocabulary, and communication. It offers interactive modules, audio-visual tools, and structured content to improve listening, speaking, reading, and writing abilities, fostering confidence and fluency in learners.

[eiseryn]

Lei in front of her new clinic* in a drippy outfit. DW about how it's not lab safe as I'm sure she suits up properly when actually working with chemicals. This is her everyday outfit for seeing patients : ) Or when she's on receptionist duty.

It's been a hot minute since I drew a full illustration but I finally have a bit of time to draw again 😭 I survived 😭😭😭

I drew her so cute here 🥺🥺🥺 I did a sketch of her on pencil first so that's why she looks EXTRA good. For some reason my best drawings are ones I do on pencil first... well... usually...

Anyways I hope I get to draw more soon!!! It'll be a bit of a crunch but I need to make a piece of the twins for their birthday in 2 days (CRI) and also while it's still May I want to make a Mermay piece 😭😭😭 or a few pieces... but May is almost over I'm so 😭😭😭 why do I draw so slow CRI

in other news, this Lei will appear as a doctor in the Selenia campaign I'm running soon 👀👀👀 I wonder what my PCs' reactions will be to seeing her (although I've already hinted that she will appear). She will be selling some new interesting pharmaceuticals... surely you would trust the drugs she makes, right? : ) Surely you would trust that smile of hers, right? :3

*As of the events after the campaign, she and Elise run a clinic together. I decided to call it ELC for the first names of Elise, Lei, and Ceres :3 Although, in this AU, Gigi is there too : )

As a bonus here's the notes about her new outfit

[cleverhottubmiracle]

6 Leonard A. Lauder Passes Away At 92 The beauty and fashion worlds mourn the death of the legendary Leonard A. Lauder, who passed away at the age of 92 on June 14. Lauder was chairman emeritus of The Estée Lauder Companies Inc., which announced his death on Sunday. During his career at the company—originally founded by his mother Estée Lauder—Leonard was a leading businessman in cosmetics, joining the brand in 1968 and serving as president from 1972-1995, CEO from 1982-1999, and chairman from 1995-2005. During his tenure, he was celebrated for launching multiple brands under the Lauder roster, including Aramis, Clinique, and Lab Series—plus the acquisitions of Aveda, Bobbi Brown, Jo Malone London, La Mer, and M-A-C. Lauder’s accomplishments also included launching Lauder’s first research and development laboratory, as well as the company’s international sales growth. As chairman emeritus, Lauder continued to lead at the company and aided in beginning its ELC Cares Employee Relief Fund during the COVID-19 pandemic. His additional honors included the U.S. Navy Supply Corps Foundation’s “Lone Sailor” Award and Distinguished Alumni Award, the French government’s Légion d’Honneur, Lincoln Center Corporate Fund Women’s Leadership Council’s Women’s Leadership Award, the Palazzo Strozzi Renaissance Man of the Year Award, the New York Landmarks Conservancy’s Living Landmark honor, and a place on the World Retail Congress’ Retail Hall of Fame—in addition to the Lauder family’s 2011 Carnegie Medal of Philanthropy and a Gordon Parks Foundation Patron of the Arts Award. In addition to his role at The Estée Lauder Companies Inc., Leonard also released his popular 2020 memoir The Company I Keep: My Life in Beauty. He also served as the Breast Cancer Research Foundation’s honorary chairman of the board of directors, co-founded the Alzheimer’s Drug Discovery Foundation, and supported the Metropolitan Museum of Art—establishing the Leonard A. Lauder Research Center for Modern Art in 2013—and the Whitney Museum of American Art, where he served as a trustee and chairman emeritus from 1977-2011. He is survived by his wife Judy Glickman Lauder, son William P. Lauder; son Gary M. Lauder and his wife Laura Lauder, grandchildren Rachel, Danielle, Djuna-Bear, Joshua, and Eliana Lauder, two great-grandchildren, various stepchildren and step grandchildren, brother Ronald S. Lauder and his wife Jo Carole Lauder, and nieces, Aerin Lauder and Jane Lauder. Leonard A. Lauder (Courtesy of Estée Lauder) Sarah Jessica Parker, Colman Domingo, & More Star In W‘s TV Portfolio W magazine’s star-studded TV Portfolio is back! The publication’s annual group of top television stars shine while representing programs from And Just Like That… to The Studio, Severance, The White Lotus, The Four Seasons, and more, including Sarah Jessica Parker, Colman Domingo, Patrick Schwarzenegger, Aimee Lou Wood, Chase Sui Wonders, Sadie Sink, Jessica Williams, Owen Cooper, Jon Hamm, Julio Torres, Britt Lower, and Taylor Kitsch. Though most of the group’s interviews with Lynn Hirschberg and editorials by Daniel Arnold launch between June 17-18, Parker and Domingo‘s are now live—which you can read on WMagazine.com. Each reflect on their headline-making performances and behind-the-scenes happenings over the years, including Domingo’s newfound heartthrob status and Parker’s views on fashion within Sex and the City. “It wasn’t really,” Parker said on fashion’s role in the SATC franchise. “I’ve never seen the pilot episode but once, but the fashion is not dictating. It was only when we decided to go to series that we met with Pat Field, because I had done Miami Rhapsody with her. That’s when fashion started to play a more significant role. We had no budget the first season. It’s all from [the consignment store] Ina, Century 21, and any favors that Pat had. But not favors inside fashion houses—favors inside some friends’ warehouses in Miami and a couple of honeypots in New York. Fashion was a significant part of Carrie Bradshaw’s life, but the ways in which we could illustrate that changed over time.” Sarah Jessica Parker Colman Domingo All images: Daniel Arnold  Nordstrom Sets Up Shop In Brooklyn Nordstrom Local is heading across the bridge! Nordstrom‘s latest project is opening its newest location in Williamsburg on June 26. The shop’s in-person services include online order pick-ups, returns, and alterations from Nordstrom and Nordstrom Rack, as well as complimentary gift wrapping for Nordstrom purchases; the store can also wrap non-Nordstrom purchases for a fee. Customers can also donate gently used shoes and clothes to Housing Works, as well as empty beauty packaging for recycling in the store’s BEAUTYCYCLE program. The full range of on-site services will be available at the store at 154 N 7th Street, Brooklyn, NY 11249, in addition to Nordstrom’s previous Nordstrom Local locations in the Upper East Side and West Village neighborhoods of New York City. Nordstrom Local (Courtesy of Nordstrom) Bloomingdale’s AQUA Brand Drops A Boho Collab With Ava Phillippe Bloomingdale’s is ready for summer with its latest AQUA collab! The brand has teamed up with actress and model Ava Phillippe—daughter of Reese Witherspoon and Ryan Phillippe—for a new limited-edition collection, inspired by California style and the ease of ’90s dressing. Phillippe’s bohemian capsule includes an array of dresses, denim, lightweight blouses, boots, and sandals adorned with accents like ruffles, delicate eyelets and studs—plus sweaters and T-shirts detailed with Phillippe’s own artwork. Fashion fans can shop the collection now—which retails from $68 to $298—at Bloomingdale’s stores and Bloomingdales.com. “I’m a California girl at heart, so I knew I wanted this collection to reflect the sun-soaked, carefree aesthetic of where I grew up,” Phillippe said in a statement. “I wanted everything to have a sense of nostalgic dreaminess— pastels, vintage-inspired florals, lace— juxtaposed against bolder elements like studs and chunky jewelry. I’ve always loved drawing & creating, so I’m delighted to be able to include some of my original artwork on some of the pieces. It really feels like I’ve put my personal stamp on the collection in that way. Bloomingdale’s brought all my inspirations to life with this AQUA collection, and I’m so proud and excited to share what we’ve created.” All images: Courtesy of Bloomingdale’s Subscribe to our newsletter and follow us on Facebook and Instagram to stay up to date on all the latest fashion news and juicy industry gossip. // Allow detecting when fb api is loaded. function Deferred() var self = this; this.promise = new Promise( function( resolve, reject ) self.reject = reject; self.resolve = resolve; ); window.fbLoaded = new Deferred(); window.fbAsyncInit = function() FB.init( appId : '374762726405868', autoLogAppEvents : true, xfbml : true, version : 'v3.0' ); window.fbLoaded.resolve(); ; (function(d, s, id) var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = " fjs.parentNode.insertBefore(js, fjs); (document, 'script', 'facebook-jssdk')); Source link

[norajworld]

6 Leonard A. Lauder Passes Away At 92 The beauty and fashion worlds mourn the death of the legendary Leonard A. Lauder, who passed away at the age of 92 on June 14. Lauder was chairman emeritus of The Estée Lauder Companies Inc., which announced his death on Sunday. During his career at the company—originally founded by his mother Estée Lauder—Leonard was a leading businessman in cosmetics, joining the brand in 1968 and serving as president from 1972-1995, CEO from 1982-1999, and chairman from 1995-2005. During his tenure, he was celebrated for launching multiple brands under the Lauder roster, including Aramis, Clinique, and Lab Series—plus the acquisitions of Aveda, Bobbi Brown, Jo Malone London, La Mer, and M-A-C. Lauder’s accomplishments also included launching Lauder’s first research and development laboratory, as well as the company’s international sales growth. As chairman emeritus, Lauder continued to lead at the company and aided in beginning its ELC Cares Employee Relief Fund during the COVID-19 pandemic. His additional honors included the U.S. Navy Supply Corps Foundation’s “Lone Sailor” Award and Distinguished Alumni Award, the French government’s Légion d’Honneur, Lincoln Center Corporate Fund Women’s Leadership Council’s Women’s Leadership Award, the Palazzo Strozzi Renaissance Man of the Year Award, the New York Landmarks Conservancy’s Living Landmark honor, and a place on the World Retail Congress’ Retail Hall of Fame—in addition to the Lauder family’s 2011 Carnegie Medal of Philanthropy and a Gordon Parks Foundation Patron of the Arts Award. In addition to his role at The Estée Lauder Companies Inc., Leonard also released his popular 2020 memoir The Company I Keep: My Life in Beauty. He also served as the Breast Cancer Research Foundation’s honorary chairman of the board of directors, co-founded the Alzheimer’s Drug Discovery Foundation, and supported the Metropolitan Museum of Art—establishing the Leonard A. Lauder Research Center for Modern Art in 2013—and the Whitney Museum of American Art, where he served as a trustee and chairman emeritus from 1977-2011. He is survived by his wife Judy Glickman Lauder, son William P. Lauder; son Gary M. Lauder and his wife Laura Lauder, grandchildren Rachel, Danielle, Djuna-Bear, Joshua, and Eliana Lauder, two great-grandchildren, various stepchildren and step grandchildren, brother Ronald S. Lauder and his wife Jo Carole Lauder, and nieces, Aerin Lauder and Jane Lauder. Leonard A. Lauder (Courtesy of Estée Lauder) Sarah Jessica Parker, Colman Domingo, & More Star In W‘s TV Portfolio W magazine’s star-studded TV Portfolio is back! The publication’s annual group of top television stars shine while representing programs from And Just Like That… to The Studio, Severance, The White Lotus, The Four Seasons, and more, including Sarah Jessica Parker, Colman Domingo, Patrick Schwarzenegger, Aimee Lou Wood, Chase Sui Wonders, Sadie Sink, Jessica Williams, Owen Cooper, Jon Hamm, Julio Torres, Britt Lower, and Taylor Kitsch. Though most of the group’s interviews with Lynn Hirschberg and editorials by Daniel Arnold launch between June 17-18, Parker and Domingo‘s are now live—which you can read on WMagazine.com. Each reflect on their headline-making performances and behind-the-scenes happenings over the years, including Domingo’s newfound heartthrob status and Parker’s views on fashion within Sex and the City. “It wasn’t really,” Parker said on fashion’s role in the SATC franchise. “I’ve never seen the pilot episode but once, but the fashion is not dictating. It was only when we decided to go to series that we met with Pat Field, because I had done Miami Rhapsody with her. That’s when fashion started to play a more significant role. We had no budget the first season. It’s all from [the consignment store] Ina, Century 21, and any favors that Pat had. But not favors inside fashion houses—favors inside some friends’ warehouses in Miami and a couple of honeypots in New York. Fashion was a significant part of Carrie Bradshaw’s life, but the ways in which we could illustrate that changed over time.” Sarah Jessica Parker Colman Domingo All images: Daniel Arnold  Nordstrom Sets Up Shop In Brooklyn Nordstrom Local is heading across the bridge! Nordstrom‘s latest project is opening its newest location in Williamsburg on June 26. The shop’s in-person services include online order pick-ups, returns, and alterations from Nordstrom and Nordstrom Rack, as well as complimentary gift wrapping for Nordstrom purchases; the store can also wrap non-Nordstrom purchases for a fee. Customers can also donate gently used shoes and clothes to Housing Works, as well as empty beauty packaging for recycling in the store’s BEAUTYCYCLE program. The full range of on-site services will be available at the store at 154 N 7th Street, Brooklyn, NY 11249, in addition to Nordstrom’s previous Nordstrom Local locations in the Upper East Side and West Village neighborhoods of New York City. Nordstrom Local (Courtesy of Nordstrom) Bloomingdale’s AQUA Brand Drops A Boho Collab With Ava Phillippe Bloomingdale’s is ready for summer with its latest AQUA collab! The brand has teamed up with actress and model Ava Phillippe—daughter of Reese Witherspoon and Ryan Phillippe—for a new limited-edition collection, inspired by California style and the ease of ’90s dressing. Phillippe’s bohemian capsule includes an array of dresses, denim, lightweight blouses, boots, and sandals adorned with accents like ruffles, delicate eyelets and studs—plus sweaters and T-shirts detailed with Phillippe’s own artwork. Fashion fans can shop the collection now—which retails from $68 to $298—at Bloomingdale’s stores and Bloomingdales.com. “I’m a California girl at heart, so I knew I wanted this collection to reflect the sun-soaked, carefree aesthetic of where I grew up,” Phillippe said in a statement. “I wanted everything to have a sense of nostalgic dreaminess— pastels, vintage-inspired florals, lace— juxtaposed against bolder elements like studs and chunky jewelry. I’ve always loved drawing & creating, so I’m delighted to be able to include some of my original artwork on some of the pieces. It really feels like I’ve put my personal stamp on the collection in that way. Bloomingdale’s brought all my inspirations to life with this AQUA collection, and I’m so proud and excited to share what we’ve created.” All images: Courtesy of Bloomingdale’s Subscribe to our newsletter and follow us on Facebook and Instagram to stay up to date on all the latest fashion news and juicy industry gossip. // Allow detecting when fb api is loaded. function Deferred() var self = this; this.promise = new Promise( function( resolve, reject ) self.reject = reject; self.resolve = resolve; ); window.fbLoaded = new Deferred(); window.fbAsyncInit = function() FB.init( appId : '374762726405868', autoLogAppEvents : true, xfbml : true, version : 'v3.0' ); window.fbLoaded.resolve(); ; (function(d, s, id) var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = " fjs.parentNode.insertBefore(js, fjs); (document, 'script', 'facebook-jssdk')); Source link

[digitallab007]

Why ELCS Labs Are a Must-Have in Today’s Education System

In the current academic landscape, simply knowing English isn’t enough. Students today must be able to communicate clearly, confidently, and effectively—not only in exams but also in real-life situations, interviews, and professional settings. That’s where ELCS Labs (English Language Communication Skills Labs) come in.

At the heart of this transformation is the Digital Teacher ELCS Lab Software, designed to help institutions modernize the way they teach English. With technology playing a bigger role in education, having a digital language lab is no longer a luxury—it’s a necessity.

What is an ELCS Lab?

ELCS stands for English Language Communication Skills. It’s a structured lab setup that allows students to practice the LSRW skills — Listening, Speaking, Reading, and Writing.

Traditional teaching methods often focus on grammar and textbooks, but they miss the practical side of language. An ELCS Lab, especially one powered by Digital Teacher, fills that gap by providing a hands-on, interactive environment.

Why Do Colleges Need It?

1. Better Student Engagement

Digital Teacher’s ELCS Lab Software includes multimedia lessons, voice recording features, quizzes, and interactive exercises. These tools keep students engaged and motivated to learn.

2. Improved Communication Skills

Students not only learn English—they practice speaking it. With pronunciation correction and listening exercises from native speakers, their confidence grows naturally.

3. Job-Readiness

Communication skills are critical during placements and job interviews. ELCS Labs help students develop the soft skills employers look for.

4. Aligned with University Syllabus

https://www.englishlab.co.in/blog/wp-content/uploads/2025/05/Features-of-English-Language-Lab-Software.jpg

Features of Digital Teacher ELCS Lab

Pre-recorded native speaker content

Grammar and vocabulary modules

Audio-visual presentations

Pronunciation and intonation practice

Instructor monitoring dashboard

Works without internet after installation

These features make it easy for colleges to adopt and integrate the software into their existing systems.

Changing the Face of Classrooms

https://www.englishlab.co.in/blog/wp-content/uploads/2025/05/English-Language-Lab-3.png

Language is power. In today’s globalized world, students need more than theory—they need practical language skills. By adopting ELCS Lab Software from Digital Teacher, colleges can give their students a strong foundation for academic and career success.

– Step into the future of learning. – Embrace digital transformation. – Welcome to ELCS Labs.

[elceclinic]

Effective Relief and Long-Term Healing

 If you're dealing with persistent stomach pain or acidity, ELCE Clinics offers advanced peptic ulcer treatment in Coimbatore. Our specialists use the latest endoscopy and lab diagnostics to identify the root cause of ulcers and provide targeted therapies. Whether caused by infection or lifestyle habits, our personalized care helps you recover quickly while preventing recurrence. With expert monitoring and supportive guidance, we ensure your digestive health stays on track.

For more details, visit: https://elceclinics.com/blog/peptic-ulcer/

[masquerade-of-time]

FINAL MUZE BACKSTORY!!!

Zane's Backstory!

Zane doesnt have much of a backstory, and all they know of their creation was they were created in some.. lab like place in Mistral.. but they dont know much elce, as just after they were made and got used to actually.. existing.. they got taken to Beacon with Udell and.. somehow got accepted into the school? Zane has no clue how, honestly. But their pretty happy. They enjoy their team(COUGH COUGH Ebony COUGH) and they enjoy being at Beacon.. but Udell is a jerk and keeps a lot of secrets about them from them

[spaceexp]

Space Station Science Highlights: Week of January 20, 2020

ISS - Expedition 61 Mission patch. Jan. 24, 2020 The week of Jan. 20, crew members aboard the International Space Station worked on a number of scientific investigations, including studies of using probiotics to improve immune health and of complex plasmas, as well as measurements of black holes and Earth’s upper atmosphere. NASA astronauts Jessica Meir and Christina Koch conducted their third spacewalk together on Jan. 20, completing replacement of batteries that store and distribute solar power on the space station. The crew also continued operations for the departure of the Cygnus cargo craft, currently planned for Jan. 31, and NASA astronaut Andrew Morgan and Luca Parmitano of ESA (European Space Agency) prepared for Saturday’s fourth and final spacewalk to repair the Alpha Magnetic Spectrometer (AMS-02).

Image above: NASA astronaut Jessica Meir uses pistol grip tools while attached to an articulating portable foot restraint during her third spacewalk with NASA astronaut Christina Koch to finalize an upgrade for power systems on the International Space Station. Image Credit: NASA. Now in its 20th year of continuous human presence, the space station provides a platform for long-duration research in microgravity and for learning to live and work in space. Experience gained on the orbiting lab supports Artemis, NASA’s program to go forward to the Moon and on to Mars. Here are details on some of the microgravity investigations currently taking place: Studying complex plasmas The crew took photos of the Plasma Krystall-4 (PK-4) system and packed hard drives for return to Earth on a Soyuz supply craft. A collaboration between the European Space Agency (ESA) and the Russian Federal Space Agency (ROSCOSMOS), PK-4 studies complex plasmas, or low temperature gaseous mixtures of ionized gas, neutral gas, and micron-sized particles. When the micro-particles become highly charged, they interact strongly with each other and can form self-organized structures called plasma crystals. Plasmas occur throughout the universe, from the interstellar medium to the heat shields of spacecraft re-entering Earth's atmosphere. Understanding how plasma crystals form in microgravity could shed light on plasma phenomena in space and lead to new research methods and improved spacecraft designs. Analyzing different influences on complex plasmas also could lead to improvements in industries that use plasmas on Earth. Beneficial bacteria Probiotics are live microorganisms that aid human digestion. The Probiotics investigation studies whether these beneficial bacteria improve the human intestinal microbiota and immune function. Some species of harmful bacteria may grow stronger in microgravity, while the human immune system becomes weaker in space, leading to increased risk to the health of astronauts on long-duration missions. Incorporating probiotics into food for future space missions could provide basic nutrition and help safeguard the health of crew members. The investigation also could shed light on changes that take place in bacteria during spaceflight, benefiting efforts to reduce infections. The crew performed sampling activities for the ongoing investigation during the week. Meanwhile, outside the space station

Image above: View of the Neutron Star Interior Composition ExploreR (NICER) device attached to ExPRESS (Expedite the Processing of Experiments to Space Station) Logistics Carrier-2 (ELC-2). NICER observed matter orbiting within a few hundred kilometers of the event horizon, evidence confirming the object as a relatively lightweight black hole binary. Image Credit: NASA. The Neutron star Interior Composition Explorer (NICER) provides high-precision measurements of neutron stars and other X-ray astrophysics phenomena through observations in the electromagnetic band in which these stars radiate significant portions of their energy. Since July of 2019, NICER has been observing a recent outburst of the X-ray binary EXO 1846-031, last detected in 1985. The mission measured the most ever high frequency quasi-periodic oscillations (QPOs), oscillations related to matter orbiting at a significant fraction of the speed of light within a few hundred kilometers of the event horizon, the boundary beyond which even light cannot escape and, thus, nothing can be observed. The data provide evidence confirming the object as a relatively lightweight black hole binary, only three to four times the Sun’s mass.

Animation above: SAGE-III, an instrument attached to the outside of the space station, collects measurements of stratospheric ozone and other gases, water vapor, and aerosols, or tiny particles in the atmosphere, which together protect life on Earth from some of the harsh effects of the Sun. Animation Credit: NASA. Another instrument on the outside of the space station, SAGE-III, began operation in July 2017 and continues to collect measurements of stratospheric ozone and other gases, water vapor, and aerosols, or tiny particles in the atmosphere. These essentially make up Earth’s “sunscreen,” protecting the planet and life on it from some of the harsh effects of solar radiation. Other investigations on which the crew performed work: - Food Acceptability examines the effect of repetitive consumption of the food currently available during spaceflight. “Menu fatigue” from a limited choice of foods over time may contribute to the loss of body mass often experienced by crew members, potentially affecting astronaut health, especially as mission length increases. https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=7562 - Standard Measures captures an ongoing, optimized set of measures from crew members to characterize how their bodies adapt to living in space. Researchers use these measures to create a data repository for high-level monitoring of the effectiveness of countermeasures and better interpretation of health and performance outcomes. https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=7711 - ISS HAM gives students an opportunity to talk directly with crew members via ham radio when the space station passes over their school. This interaction engages and educates students, teachers, parents and other members of the community in science, technology, engineering and math. https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=337 - Actiwatch, a sleep-wake monitor worn by a crew member, analyzes circadian rhythms, sleep-wake patterns, and activity. The data are used in a number of studies on sleep and biological rhythms. https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Facility.html?#id=838 - The Cold Atom Laboratory (CAL) produces clouds of atoms chilled to temperatures much colder than deep space so scientists can study fundamental behaviors and quantum characteristics that are difficult or impossible to probe at higher temperatures. https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Facility.html?#id=7396 - Astronauts show accelerated arterial stiffening, thicker artery walls, and other aging-like changes after spending six months in space. Vascular Aging monitors these changes using artery ultrasounds, blood samples, and other measures to identify risk and possible mechanisms for reducing that risk. https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=7644 - HERMES is a reconfigurable, on-orbit facility for providing long-duration exposure to the microgravity and vacuum conditions of space. It provides customizable experiment tools, data downlink, data storage, autonomous monitoring, and ground commanding of lighting and cameras. https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Facility.html?#id=7557

Space to Ground: Upgrading the Station: 01/24/2020

Related links: Alpha Magnetic Spectrometer (AMS-02): https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=729 Plasma Krystall-4 (PK-4): https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=1192 Probiotics: https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=2047 Neutron star Interior Composition Explorer (NICER): https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=1705 SAGE-III: https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=976 ISS National Lab: https://www.issnationallab.org/ Spot the Station: https://spotthestation.nasa.gov/ Space Station Research and Technology: https://www.nasa.gov/mission_pages/station/research/index.html International Space Station (ISS): https://www.nasa.gov/mission_pages/station/main/index.html Images (mentioned), Animation (mentioned), Video (NASA), Text, Credits: NASA/Michael Johnson/John Love, Lead Increment Scientist Expedition 61. Best regards, Orbiter.ch Full article

[snows-labcoat]

Side Effects Include: [1/2]

Summary: New Message for: Caitlin Snow.

Would you like me to play it?

In which, they’re trapped.

Pairing: Caitlin Snow x Reader

Read: Part 2 (coming soon)

//

Or,, the SING au loosely based off the music video by MCR.

Historic facts I changed for this story and a disclaimer: The Emergency Broadcast system wasn’t invented until the Cold War. I’ve changed this so it was invented earlier during WWII. FDR was President and none of this reflects my political views. He just happened to be our President during this war so he’s the one endorsing.

~~

We interrupt our Programming, this is a national Emergency, important instructions will follow. The following message is transmitted at the request of the United States Government.

**This is not a test, repeat, this is not a test.**

Mandatory instructions will follow after the beep. I repeat, you are required to follow the upcoming text prompts.

***

This is a message from the United States Government...

...Please do not panic.

At your doorstep...

...you will find a blue pill bottle.

We need you to bring it inside.

Once you have it in your hand...

...take one pill with a glass of water.

This is a national emergency...

...Failure to follow procedure will result in fatality.

It is your duty as citizens to serve your country.

Honor yourselves...

...and the people fighting this war.

Continue to take one pill each day...

...This is for your benefit.

It is vital that you do as we say.

Thank you for serving...

...You will not regret this.

***

Caitlin sat in her room, alone and tired. She felt as if the gray walls were mocking her, impeccably smooth. Too smooth.

She knew she was on thin ice with work, and staying up until 4 am wouldn’t help her but she couldn’t sleep.

Her mind... it was racing. She wasn’t used to it at all. It had started out small, when she saw a bird sitting in a tree outside her work. She couldn’t take her eyes off of it. There was something mesmerizing about the way it flew before she just shook her head and returned to work, attempting to shrug the feeling off.

It continued, she found herself wanting to coo at the toddler as he held his mother’s hand every morning on the way to school.

When the screen in her room would report news, she found herself sad when a death was announced.

Then she met you.

You had recently started a job with the same company, working as bio-engineers. More specifically, geneticists.

“EnLight Corp only wants to take away what’s natural! So let’s give in to what we all want to do”

Your task? To find a permanent solution. Eradicate the world of emotions. The pill had been developed 75 years ago during WWII. It was designed for soldiers so nothing would be compromised by our only weakness. Feeling.

“Keep our country alive. The solution is right here. Ingestible, sterile, safe. No more will we have to worry. I have been working with EnLight and together, we will win this war.”

Conspiracy theorists say that in the beginning of WWII, FDR and EnLight Corp. began to give civilians the pill but nobody has any record of that. To everyone else, it started to get pumped into society around 2010. It seemed every advertisement was pushing for this “enlightenment.”

Of course, nobody told the truth. EnLight and the government did whatever it took. They lied. Claiming that the lack of emotion was merely a temporary side effect for a pill meant to be an effective and easier way to vaccinate.

Over time, people stopped feeling, so they stopped caring. They took the pills, not realizing that as time moved on, they were being isolated. Government started to do whatever they wanted. Mercenaries hired by them soon littered the streets, eradicating the world of the sickly homeless. And people didn’t care. People continued to watch as these “Visionaries” (as the media called them) took lives away to serve EnLight.

“These mercenaries, they hide behind their masks and shamelessly pull their triggers over and over! We are being silenced.”

Nobody cared when they moved everyone out of their homes and into bland complexes. Nobody cared when they started to take away kids to raise as Visionaries. Nobody cared while the government and ELC continued to work together, slowly ridding you and everyone else of any differences. People wore the same white top and black pants every day, they ate from the same menu, they watched the same news program at the same exact time.

Slowly, that became life. To the population of your country, nobody else existed. You became sheltered.

People tried to fight it at first. Caitlin Snow watched as her own mother began to work at ELC. It pushed them apart as Carla stopped caring. Cait watched her dad get shot when he tried to escape with her. What scared Caitlin the most was that she didn’t cry at all. There was a tug in her chest but— after that? Nothing. Two weeks of being lied to and taking those pills and changes were already happening

“They do not care about us or what happens! To them, we’re a collectible safe and I, for one, can’t stand it! Throw away the pills, give in to what’s natural. Get angry! Fight back, make noise— do whatever it takes”

You had become the leader of a rebellion. But nobody else had to find out.

You took this job as a cover. You wanted inside information. And you were gonna get it.

When you met Dr. Snow, she was polite. Shaking your hand and greeting you that morning. Nothing really changed for a while. You would greet each other in the morning, but things were completely professional.

You had to keep the act up. Anyone to get caught would immediately be taken to isolation where they’d take away your pills. You’d slowly gain emotions back and it drives every person to insanity, almost always resulting in suicide.

But you just couldn’t help yourself. The chestnut haired co-worker was somehow enrapturing despite the lack of emotions.

You really didn’t mean to fall in love.

“They are stripping us of something beautiful. Today, I found myself desiring a partner. Not just to repopulate— it was more! You read about this in your books but it’s true. I felt love. Real. Fresh, undiluted, pure.”

You knew Caitlin skipped her pills. You could see in her eyes when she would feel. The way she froze when your hand brushed hers.

Fond

Adj.

having an affection or liking for

You could feel her get nervous when you stood close, looking over her shoulder at a Petri dish. You saw her close her eyes and take a deep breath after you had walked away, brushing her hand with yours gently. Her hands were braced on the solid white counter after you had smiled at her.

Excitable

Adj.

responding rather too readily to something new or stimulating; too easily excited.

It wasn’t just a normal, polite greeting smile. She could tell there was something...human about it.

Two weeks later she heard you singing, it was unexpected but her heart pounded in her chest. She kept her back towards you while you paced around the lab, organizing materials.

Enamored

Verb.

Be filled with a feeling of love for

Caitlin hated to admit it but... she didn’t want to give this up. She had forgotten what a genuine smile felt like. She had forgotten what it felt like to wake up and be excited for once.

She knew it was wrong. She knew the consequences. She knew what could happen to both of you if this continued.

Guilt

Noun.

a feeling of having done wrong or failed in an obligation

but she couldn’t stop herself from lightly intertwining her fingers with yours while you worked. She couldn’t stop herself from crying when you had hugged her for the first time. She couldn’t stop herself from kissing back with the intensity of a thousand supernovas.

Love

Noun.

An intense feeling of deep affection.

She— she couldn’t stop herself from the anger coursing through her words as you had been dragged away, the redness of her cheeks matching the way her eyes burned.

Broken

Adj.

(of a person) having given up all hope; despairing.

Caitlin Snow had always been a rule follower. Now she reads the rules before she breaks them.

[leyhejuhyunghan]

Nature Ecology & Evolution The structure of genotype-phenotype maps makes fitness landscapes navigable, FITNESS LANDSCAPES Life finds a way, ley, Ley line, Alfred Watkins (English archaeologist, 1855–1935), Fernand Khnopff (Belgian, 1858-1921), Bible Ephesians 4:16, Mighty to Save - Hillsong Worship, Des'ree - Life (Official Video), MGH Institute NLN Education Summit “Healthy Planet, Healthy People: Leading the Way Through Education, Practice, and Policy”, ‘The Academy of American Poets Fishmonger - Marsden Hartley (American, 1877–1943), An October Garden - Christina Rossetti (English, 1830-94), El Greco, Schoenberg Institute for Manuscript Studies Manuscript Monday: Ms. Codex 1645 – Technical treatise on the painting of miniatures, The Estée Lauder Companies #ClimateWeekNYC Climate Group

Nature Ecology & Evolution The structure of genotype-phenotype maps makes fitness landscapes navigable, FITNESS LANDSCAPES Life finds a way, ley, Ley line, Alfred Watkins (English archaeologist, 1855–1935), Fernand Khnopff (Belgian, 1858-1921), Bible Ephesians 4:16, Mighty to Save - Hillsong Worship, Des'ree - Life (Official Video), MGH Institute NLN Education Summit “Healthy Planet, Healthy People: Leading the Way Through Education, Practice, and Policy”, ‘The Academy of American Poets Fishmonger - Marsden Hartley (American, 1877–1943), An October Garden - Christina Rossetti (English, 1830-94), El Greco, Schoenberg Institute for Manuscript Studies Manuscript Monday: Ms. Codex 1645 – Technical treatise on the painting of miniatures, The Estée Lauder Companies #ClimateWeekNYC Climate Group NatureEcoEvo Nature Ecology & Evolution The structure of genotype-phenotype maps makes fitness landscapes navigable, FITNESS LANDSCAPES Life finds a way, ley an area of land where grass is grown temporarily instead of crops, Ley line, Ley lines are straight alignments drawn between various historic structures and prominent landmarks., Alfred Watkins (English archaeologist, 1855–1935) in 1921 he noticed on the British landscape an apparent arrangement of straight lines positioned along ancient features., Fernand Khnopff (Belgian, 1858-1921), Femme Mysterieuse (Mysterious Woman), 1891 by Christa Zaat, the Bible Ephesians 4: Unity and Maturity in the Body of Christ 16 ‘From him the whole body, joined and held together by every supporting #ligament, grows and builds itself up in love, as each part does its work.’ from Hillsong Church Sunday worship, Mighty to Save - Hillsong Worship, Des'ree - Life (Official Video), MGH Institute NLN Education Summit “Healthy Planet, Healthy People: Leading the Way Through Education, Practice, and Policy”, ‘Teaching for Clinical Reasoning and Rapid Clinical Decision Making: Keys to Developing Expertise in Practice’, Center for the Environment and Health, Speech and Language Literacy Lab, MGH Institute Department of Communication Sciences and Disorders, Poets.org The Academy of American Poets Fishmonger - Marsden Hartley (American, 1877–1943) ‘I sit on the bank of the stream and watch, The grasses in amazement’, Marsden Hartley, Abstraction, 1914, Museum of Fine Arts, Houston., An October Garden - Christina Rossetti (English, 1830-94) ‘That least and last which cold winds balk; A rose it is though least and last of all, A rose to me though at the fall.’, El Greco (Crete, 1541-Toledo, 1614), The Annunciation, 1596-1600, Museo de Bellas Artes de Bilbao., Schoenberg Institute for Manuscript Studies Manuscript Monday: Ms. Codex 1645 – Technical treatise on the painting of miniatures, ‘Includes information on the reduction of images and mixes of pigments for landscapes, skies, varieties of flowers, skin, faces, drapery, and jewels.’, The Estée Lauder Companies #ClimateWeekNYC Climate Group on the global effort to address climate change, The Estée Lauder Companies (ELC) has been a leading supporter of Climate Week NYC over the past six years. 

https://blog.naver.com/artnouveau19/222892309616

https://www.nature.com/articles/s41559-022-01867-z?fbclid=IwAR3XAmhSOUfwfWuZ7ANBt9CliZbAFlLZKXj-qXZAfNrrhcOcfQ0J2xDIn_Y

https://www.nature.com/articles/s41559-022-01877-x

https://www.oxfordlearnersdictionaries.com/definition/english/ley

https://en.wikipedia.org/wiki/Ley_line

https://en.wikipedia.org/wiki/Alfred_Watkins https://www.facebook.com/photo/?fbid=10159308043252151&set=a.10151465215597151 https://www.biblegateway.com/passage/?search=Ephesians%204&version=NIV

https://youtu.be/GEAcs2B-kNc https://youtu.be/BKtrWU4zaaI

https://summit.nln.org

https://www.massgeneral.org/environment-and-health

https://www.mghihp.edu/research/speech-and-language-literacy-sail-lab?fbclid=IwAR1WUr2cSaIWdw-TyfAo0A7X6_5z-zrfzgegD0cx1csTc1GlxCR8388zT7g

https://www.mghihp.edu/academics/communication-sciences-and-disorders-home?fbclid=IwAR149HBYSBRYAlETO4MSOxWNcv079OlnteWC0TxM9oS7EKqmndEh6fBVZDk https://poets.org/poem/fishmonger?fbclid=IwAR0oy1VtB9SBj0ayiSjaVkzGa9hfvi7Xei-k8x4d_LWkn2c9CUopcPDMC1M https://en.wikipedia.org/wiki/Marsden_Hartley https://en.wikipedia.org/wiki/Marsden_Hartley#/media/File:Marsden_Hartley_-_Abstraction_-_Google_Art_Project.jpg

https://poets.org/poem/october-garden?fbclid=IwAR3kSu15QOVi-dnhrGGv4yPA0XVW63orblH8YBWlZ5stuqf-reOGjSDu1gk

https://en.wikipedia.org/wiki/Christina_Rossetti

https://bilbaomuseoa.eus/en/artworks/the-annunciation-69-116/

https://schoenberginstitute.org/2022/10/03/manuscript-monday-ms-codex-1645-technical-treatise-on-the-painting-of-miniatures/

https://www.climateweeknyc.org/news/qa-headline-partner-estee-lauder-companies

NatureEcoEvo

@NatureEcoEvo

·

Sep 30

The structure of genotype-phenotype maps makes fitness landscapes navigable 

https://twitter.com/NatureEcoEvo/status/1575778980937990144

https://www.nature.com/articles/s41559-022-01867-z.epdf?sharing_token=Q-cWSC3Dt0rqu8bDEiZcjtRgN0jAjWel9jnR3ZoTv0PCdBt_t7HPzaxTcnUb1bhQDJV4SHGRy18A7ZlkZTnWeG_gii4QWyxcYz3yOYY2LwBjB06j2evHmWqpHe_M-Oh2mxy5PauUnBw0BfU9qT6WncqN5Aor-SgHN9eNwQlhNwA%3D

Nature Ecology & Evolution

In realistic high-dimensional fitness landscapes of RNA secondary structure, protein tertiary structure and protein complexes, authors of a new Article in Nature Ecology & Evolution find that fitness peaks can easily be reached from any starting point without traversing fitness valleys.

https://www.nature.com/articles/s41559-022-01867-z

nature nature ecology & evolution articles article

Article

Published: 29 September 2022

The structure of genotype-phenotype maps makes fitness landscapes navigable

Sam F. Greenbury, Ard A. Louis & Sebastian E. Ahnert 

Nature Ecology & Evolution (2022)Cite this article

560 Accesses

17 Altmetric

Metrics https://www.nature.com/articles/s41559-022-01867-z?fbclid=IwAR3XAmhSOUfwfWuZ7ANBt9CliZbAFlLZKXj-qXZAfNrrhcOcfQ0J2xDIn_Y

Abstract

Fitness landscapes are often described in terms of ‘peaks’ and ‘valleys’, indicating an intuitive low-dimensional landscape of the kind encountered in everyday experience. The space of genotypes, however, is extremely high dimensional, which results in counter-intuitive structural properties of genotype-phenotype maps. Here we show that these properties, such as the presence of pervasive neutral networks, make fitness landscapes navigable. For three biologically realistic genotype-phenotype map models—RNA secondary structure, protein tertiary structure and protein complexes—we find that, even under random fitness assignment, fitness maxima can be reached from almost any other phenotype without passing through fitness valleys. This in turn indicates that true fitness valleys are very rare. By considering evolutionary simulations between pairs of real examples of functional RNA sequences, we show that accessible paths are also likely to be used under evolutionary dynamics. Our findings have broad implications for the prediction of natural evolutionary outcomes and for directed evolution.

Main

Ever since they were first introduced in Sewall Wright’s foundational paper1, fitness landscapes have become an enduring and central concept in evolutionary biology2,3,4,5,6. In particular, a low-dimensional picture of fitness ‘peaks’ and fitness ‘valleys’ has played an important role in shaping intuition around evolutionary dynamics. A key prediction is that a population must typically traverse an unfavourable valley of lower fitness to move from one fitness peak to another. But, as already pointed out by many since4,7,8,9,10,11, the space of genotypes is typically extremely high dimensional. As illustrated in Fig. 1, what appears to be a fitness valley in a lower-dimensional landscape could be easily bypassed when dimensions are added9,10,11.

Three key open questions are: (1) does the low-dimensional picture of fitness valleys hold for realistic high-dimensional genotype spaces? And if we define accessible paths of point mutations between a low fitness phenotype and a high fitness phenotype as those with monotonically increasing fitness, (2) what properties of biological systems facilitate their presence and (3) are such paths sufficiently common that they can easily be found by an evolving population?

One way forward is to consider empirical fitness landscapes, where much recent progress has been made5,12, particularly for molecular phenotypes5,13,14,15,16,17,18,19,20,21. This body of work has yielded important insights, such as the role of local epistatic interactions in sculpting evolutionary paths22,23,24. Nevertheless, ruling out high-dimensional bypasses is difficult in empirical studies because genotype spaces, which grow exponentially as KL for alphabet size K and genotype length L, are almost always unimaginably vast25. They are also highly connected since distances are linear; two genotypes are at most L point mutations away, but are connected by up to L! shortest possible paths given the L mutations may occur in any order. For example, even for a very short L = 20 strand of RNA, there are up to 20! ≅ 2 × 1018 paths between any two genotypes. Empirical landscapes can typically only ever sample a small fraction of the full genotype space, so what appears to be an isolated fitness peak, may in fact be accessible via pathways not included in the experiment.

A different strand of work, which can in principle address questions of global accessibility, has focused on model genotype-to-fitness landscapes3,6,10,11,26,27. If fitness is assigned randomly to genotypes, as in Kingman’s ‘house of cards’ model28, then the probability of finding accessible paths is small. If instead there are correlations between fitness and the genotypes, then, depending on details of the model, accessible paths can indeed be common11,29. These correlations are often expressed in terms of ruggedness: a more rugged model has fewer correlations between genotypes and fitness, and so is less navigable. While much progress has been made in this literature, it is not clear how well these models capture the true correlations of biological fitness landscapes.

Here we take a different approach, and build on recent advances showing that many realistic genotype-phenotype (GP) maps share generic structural features that can enhance navigability30,31,32. In contrast to the genotype-to-fitness models studied by others (above), we consider the genotype-to-phenotype-to-fitness map by inserting the GP map as an additional intermediate step that provides the non-random organization of the mapping from genotypes to fitness. This means correlations in fitness are naturally incorporated as a consequence of the GP map, rather than through an assumption explicitly parameterized.

Fig. 1: High-dimensional bypasses facilitate landscape navigability. Illustration of how increasing dimensionality D of the genotype space can affect the navigability and presence of valleys in a fitness landscape.

https://www.nature.com/articles/s41559-022-01867-z?fbclid=IwAR3XAmhSOUfwfWuZ7ANBt9CliZbAFlLZKXj-qXZAfNrrhcOcfQ0J2xDIn_Y

NatureEcoEvo

@NatureEcoEvo

·

Sep 30

Realistic high-dimensional genotype–phenotype maps show that fitness maxima can be reached from almost any other phenotype while avoiding fitness valleys, which are very rare. https://twitter.com/NatureEcoEvo/status/1575809683109122050 nature nature ecology & evolution news & views article

News & Views

Published: 29 September 2022

FITNESS LANDSCAPES

Life finds a way

Jacobo Aguirre 

Nature Ecology & Evolution (2022)Cite this article

209 Accesses

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Fitness landscapes were described almost a century ago as smooth surfaces with peaks and valleys that are difficult to navigate. Now, more realistic high-dimensional genotype–phenotype maps show that fitness maxima can be reached from almost any other phenotype while avoiding fitness valleys, which are very rare.

Writing in Nature Ecology and Evolution, Greenbury et al4. show how common properties of high-dimensional genotype–phenotype maps influence the evolutionary navigability of fitness landscapes, making use of biologically realistic models and experimental databases.

https://www.nature.com/articles/s41559-022-01877-x

ley an area of land where grass is grown temporarily instead of crops, Ley line, Ley lines are straight alignments drawn between various historic structures and prominent landmarks., Alfred Watkins (English archaeologist, 1855–1935) in 1921 he noticed on the British landscape an apparent arrangement of straight lines positioned along ancient features.

ley

(also ley line) an imaginary line that is believed to follow the route of an ancient track and to have special powers (specialist) an area of land where grass is grown temporarily instead of crops https://www.oxfordlearnersdictionaries.com/definition/english/ley Ley line Ley lines (/leɪ/) are straight alignments drawn between various historic structures and prominent landmarks. The idea was developed in early 20th-century Europe, with ley line believers arguing that these alignments were recognised by ancient societies that deliberately erected structures along them. Since the 1960s, members of the Earth Mysteries movement and other esoteric traditions have commonly believed that such ley lines demarcate "earth energies" and serve as guides for alien spacecraft. Archaeologists and scientists regard ley lines as an example of pseudoarchaeology and pseudoscience.

The idea of "leys" as straight tracks across the landscape was put forward by the English antiquarian Alfred Watkins in the 1920s, particularly in his book The Old Straight Track. He argued that straight lines could be drawn between various historic structures and that these represented trade routes created by ancient British societies. Although he gained a small following, Watkins' ideas were never accepted by the British archaeological establishment, a fact that frustrated him. His critics noted that his ideas relied on drawing lines between sites established at different periods of the past. They also argued that in prehistory, as in the present, it was impractical to travel in a straight line across hilly or mountainous areas of Britain, rendering his leys unlikely as trade routes. Independently of Watkins' ideas, a similar notion—that of Heilige Linien ('holy lines')—was raised in 1920s Germany.

During the 1960s, Watkins' ideas were revived in altered form by British proponents of the countercultural Earth Mysteries movement. In 1961, Tony Wedd put forward the belief that leys were established by prehistoric communities to guide alien spacecraft. This view was promoted to a wider audience in the books of John Michell, particularly his 1969 work The View Over Atlantis. Michell's publications were accompanied by the launch of the Ley Hunter magazine and the appearance of a ley hunter community keen to identify ley lines across the British landscape. Ley hunters often combined their search for ley lines with other esoteric practices like dowsing and numerology and with a belief in a forthcoming Age of Aquarius that would transform human society. Although often hostile to archaeologists, some ley hunters attempted to ascertain scientific evidence for their belief in earth energies at prehistoric sites, evidence they could not obtain. Following sustained archaeological criticism, the ley hunter community dissipated in the 1990s, with several of its key proponents abandoning the idea and moving into the study of landscape archaeology and folkloristics. Belief in ley lines nevertheless remains common among some esoteric religious groups, such as forms of modern Paganism, in both Europe and North America.

Archaeologists note that there is no evidence that ley lines were a recognised phenomenon among ancient European societies and that attempts to draw them typically rely on linking together structures that were built in different historical periods. Archaeologists and statisticians have demonstrated that a random distribution of a sufficient number of points on a plane will inevitably create alignments of random points purely by chance. Skeptics have also stressed that the esoteric idea of earth energies running through ley lines has not been scientifically verified, remaining an article of faith for its believers. https://en.wikipedia.org/wiki/Ley_line

Alfred Watkins (English archaeologist, 1855–1935) in 1921 he noticed on the British landscape an apparent arrangement of straight lines positioned along ancient features. Alfred Watkins (27 January 1855 – 15 April 1935) was an English author, self-taught amateur archaeologist, antiquarian and businessman who, while standing on a hillside in Herefordshire, England, in 1921 experienced a revelation. He noticed on the British landscape an apparent arrangement of straight lines positioned along ancient features. For these he subsequently coined the term "ley", now usually referred to as ley line, because the line passed through places whose names contained the syllable "ley".

https://en.wikipedia.org/wiki/Alfred_Watkins

Christa Zaat added a new photo to the album: Fernand Khnopff (Belgian painter) 1858 - 1921.

Fernand Khnopff (Belgian painter) 1858 - 1921

Femme Mysterieuse (Mysterious Woman), 1891

pencil and coloured pencil on paper

28 x 17.2 cm. (11.13 x 6.87 in.)

signed FERNAND / KHNOPFF l.l.; marked with the collector's stamp of Gustav Engelbrecth l.r.

private collection

© photo Sotheby's

Catalogue Note Sotheby's

FERNAND KHNOPFF

Khnopff came from an upper middle class Belgian family of lawyers. In 1875 he began to study law at the University of Brussels, but his true passion was literature. He avidly read Flaubert, Baudelaire and Leconte de Lisle, and his circle of friends included many young writers of the day, such as Emile Verhaeren, Max Waller, Iwan Gilkin and Georges Rodenbach. It was not long before he abandoned his law degree and began studying painting under Xavier Mellery. It was in Paris at the Exposition Universelle of 1878 that he discovered the works of Gustave Moreau, John Everett Millais and Edward Burne-Jones, which were to have a decisive influence on his own artistic output. Khnopff made his artistic debut in 1881, at the Brussels Salon held by the group L'Essor. In 1883 he was a founding member of the Belgian avant-garde group Les XX and later also of La Libre Esthetique. He exhibited at the annual Salons of the Rose + Croix in Paris, at the exhibitions of the Vienna Secession, and also started to exhibit regularly in England. The Pre-Raphaelite painters Hunt, Watts, Rossetti, Ford Maddox Brown and Burne-Jones became friends. In 1895 he became a correspondent for the English periodical The Studio, whose Studio-Talk-Brussels column he edited until 1914; he also regularly contributed to the journal of the Vienna Secession, Ver Sacrum.

For Khnopff, the experience of an ideal work of art was a quasi mystical experience, which allowed one to escape the world through imagination. Typically, his paintings are highly enigmatic and have multiple layers of meaning. To achieve this, Khnopff would deliberately isolate the motifs that interested him within a composition, and rearrange them like props on a stage. By choosing and ordering fragments of images on the basis of highly personal analogies, he eliminated every reference to real space and time. Similarly to Odilon Redon (see lots 257-259) Khnopff wanted his works to be contemplated and perceived intuitively rather than analysed and fully understood. It is for this reason that he has often been referred to as a painter of the invisible. For Khnopff, the image was merely the physical expression of the philosophical objective he had set himself, namely to seek out 'ideal beauty'.

Khnopff found the personification of ideal female beauty embodied by his sister, Marguerite, and he depicted her numerous times (see lots 251, 254 and 256). His depictions of her often heighten her androgynous features. Indeed, androgyny is central to Khnopff's work and representative of his belief that women embodied the duality and ambiguity of the world.    

Khnopff very much saw himself as the genius artist who has to renounce the dangers of sensuality in order to fulfil his spiritual and artistic calling. This idea was widespread in symbolist circles at the turn of the century and found expression in the many depictions of Oedipus and the Sphinx (see lot 254). This self-imposed isolation is also expressed by one of Khnopff's maxims, 'My soul is alone and nothing influences it. It is like glass enclosed in silence, completely devoted to its interior spectacle' (quoted by Verhaeren in his memoirs), and is behind the introspective, meditative aspects of many of his works, notably his depictions of unattainable femmes fatales or saintly virgins, and especially works such as Avec Verhaeren. Un Ange, whose stillness is reminiscent of Baudelaire's poem Beauty:

I am fair, O mortals! like a dream carved in stone, 

And my breast where each finds death in turn

Is made to inspire in the poet a love 

As eternal and silent as matter.

On a throne in the sky, a mysterious sphinx, 

I join a heart of snow to the whiteness of swans; 

I hate movement for it displaces lines, 

And never do I weep and never do I laugh.

Poets, before my grandiose poses, 

Which I seem to assume from the proudest statues, 

Will consume their lives in austere study;

For I have, to enchant those submissive lovers,

Pure mirrors that make all things more beautiful:

My eyes, my large, wide eyes of eternal brightness!

(Charles Baudelaire, Flowers of Evil)

Executed circa 1909, the delicate colour harmonies of the present work illustrate the technical experimentation that continued to characterise Khnopff's work into maturity.

Mysticism and eroticism were two prevalent artistic themes at the turn of the century. Khnopff often portrayed women as sphinx-like creatures, mysterious figures harbouring untold secrets - at once vague and defined, aloof and sensual, fragile and powerful, soft and cruel.

According to Gisèle Ollinger-Zinque 'representations of women play a central role in Belgian Symbolism: the figure of Woman is seen as an embodiment of the duality and ambiguity of earthly existence. For Khnopff, Woman is by turns the angel, muse and friend who flies to Man's salvation. Yet she is also the depraved temptress, the femme fatale, the living symbol of Péladan's Le vice suprême. Angel or Demon, she is always alone, isolated from the world and unattainable. She speaks to no one and Love, the very symbol of communion, is denied her.' (Six symbolist works, Patrick Derom Gallery, Brussels, 2005, p. 23). 

Commenting on Femme Mysterieuse, Gisèle Ollinger-Zinque writes: 'This striking, idiosyncratic work, obsesses and is very intense. Around 1909, Khnopff executed a number of works which depict women covered in jewellery.... The faces of these women are enigmatic, their eyes are closed, and nothing can trouble the meditation of these inaccessible princesses of dreams.' (Fernand Khnopff,  Tokyo, Hymenia, Nagoya and Yamanashi, 1990, p. 169).

Traditionally, in the 'language' of flowers, cyclamen were a symbol of diffidence. In the nineteenth century flowers given by a man to a woman had a clear meaning. While red roses for example spoke of passion and love, the message of cyclamen was 'Votre beauté me désespère' (your beauty makes me despair). The cyclamen in the present work are thus representative of the woman's unattainablility.

The stasis of Khnopff's female protagonists is a reflection of their introspection and trance-like state. He believed that an abandonment of consciousness was at the source of dreams, and was fascinated with sleep and hypnotic states. Hypnotizing by its own distant dreaminess, the face of Femme mysterieuse is idealized and impenetrable, her closed eyes creating yet another barrier to deciphering her secret. https://www.facebook.com/photo/?fbid=10159308043252151&set=a.10151465215597151

the Bible Ephesians 4

Unity and Maturity in the Body of Christ

11 So Christ himself gave the apostles, the prophets, the evangelists, the pastors and teachers, 12 to equip his people for works of service, so that the body of Christ may be built up 13 until we all reach unity in the faith and in the knowledge of the Son of God and become mature, attaining to the whole measure of the fullness of Christ. 14 Then we will no longer be infants, tossed back and forth by the waves, and blown here and there by every wind of teaching and by the cunning and craftiness of people in their deceitful scheming 15 Instead, speaking the truth in love, we will grow to become in every respect the mature body of him who is the head, that is, #Christ. 16 From him the whole body, joined and held together by every supporting #ligament, grows and builds itself up in love, as each part does its work.

https://www.biblegateway.com/passage/?search=Ephesians%204&version=NIV

from Hillsong Church Sunday worship internet streaming service 

Mighty to Save - Hillsong Worship https://youtu.be/GEAcs2B-kNc

#Desree #Life #Vevo Des'ree - Life (Official Video) https://youtu.be/BKtrWU4zaaI

MGH Institute NLN Education Summit “Healthy Planet, Healthy People: Leading the Way Through Education, Practice, and Policy”, Teaching for Clinical Reasoning and Rapid Clinical Decision Making: Keys to Developing Expertise in Practice, Center for the Environment and Health, Speech and Language Literacy Lab, MGH Institute Department of Communication Sciences and Disorders

MGH Institute

@MGHInstitute

·

Sep 30

This year's 

@NLNSummit

 theme is, "Healthy Planet, Healthy People: Leading the Way Through Education, Practice, & Policy." Members of The Ctr. for Climate Change, Climate Justice, & Health look forward to presenting at today's #NLNSUMMIT22 Professor Rounds. https://twitter.com/MGHInstitute/status/1575834098572075008

LAS VEGAS September 28-30 Healthy Planet, Healthy People: Leading the Way Through Education, Practice, and Policy https://summit.nln.org

National Faculty Meeting

Patricia Benner, R.N., Ph.D., FAAN - University of California School of Nursing 

Teaching for Clinical Reasoning and Rapid Clinical Decision Making: Keys to Developing Expertise in Practice

https://summit.nln.org/speakers

Center for the Environment and Health

https://www.massgeneral.org/environment-and-health

Speech and Language Literacy Lab https://www.facebook.com/sailliteracylab

https://www.mghihp.edu/research/speech-and-language-literacy-sail-lab?fbclid=IwAR1WUr2cSaIWdw-TyfAo0A7X6_5z-zrfzgegD0cx1csTc1GlxCR8388zT7g MGH Institute Department of Communication Sciences and Disorders https://www.facebook.com/MGHInstituteCSD https://www.mghihp.edu/academics/communication-sciences-and-disorders-home?fbclid=IwAR149HBYSBRYAlETO4MSOxWNcv079OlnteWC0TxM9oS7EKqmndEh6fBVZDk Poets.org The Academy of American Poets Fishmonger - Marsden Hartley (American, 1877–1943) ‘I sit on the bank of the stream and watch, The grasses in amazement’, Marsden Hartley, Abstraction, 1914, Museum of Fine Arts, Houston., An October Garden - Christina Rossetti (English, 1830-94) ‘That least and last which cold winds balk; A rose it is though least and last of all, A rose to me though at the fall.’

Poets.org

@POETSorg

From all these I have made a fish of heaven for you,

Set it swimming on a young October sky.

—Marsden Hartley

https://twitter.com/POETSorg/status/1576995503635664903 Fishmonger

Marsden Hartley (American, 1877–1943) 

I have taken scales from off

The cheeks of the moon.

I have made fins from bluejays’ wings,

I have made eyes from damsons in the shadow.

I have taken flushes from the peachlips in the sun.

From all these I have made a fish of heaven for you,

Set it swimming on a young October sky.

I sit on the bank of the stream and watch

The grasses in amazement

As they turn to ashy gold.

Are the fishes from the rainbow

Still beautiful to you,

For whom they are made,

For whom I have set them,

Swimming? https://poets.org/poem/fishmonger?fbclid=IwAR0oy1VtB9SBj0ayiSjaVkzGa9hfvi7Xei-k8x4d_LWkn2c9CUopcPDMC1M https://soundcloud.com/poets-org/fishmonger-pad-2319?utm_source=clipboard&utm_campaign=wtshare&utm_medium=widget&utm_content=https%253A%252F%252Fsoundcloud.com%252Fpoets-org%252Ffishmonger-pad-2319 Marsden Hartley (January 4, 1877 – September 2, 1943) was an American Modernist painter, poet, and essayist. Hartley developed his painting abilities by observing Cubist artists in Paris and Berlin. https://en.wikipedia.org/wiki/Marsden_Hartley

Marsden Hartley (American, 1877–1943), Portrait of a German Officer, 1914, oil on canvas, 173.4 x 105.1 cm, Metropolitan Museum of Art, New York. https://en.wikipedia.org/wiki/Marsden_Hartley#/media/File:Portrait_of_a_German_Officer,_Marsden_Hartley.jpg

Marsden Hartley (American, 1877–1943), Abstraction, ca. 1914, Museum of Fine Arts, Houston. https://en.wikipedia.org/wiki/Marsden_Hartley#/media/File:Marsden_Hartley_-_Abstraction_-_Google_Art_Project.jpg

The Academy of American Poets 

In my Autumn garden I was fain

     To mourn among my scattered roses;

     Alas for that last rosebud which uncloses

—Christina Rossetti

https://poets.org/poem/october-garden?fbclid=IwAR3kSu15QOVi-dnhrGGv4yPA0XVW63orblH8YBWlZ5stuqf-reOGjSDu1gk

An October Garden

Christina Rossetti - 1830-1894

In my Autumn garden I was fain      To mourn among my scattered roses;      Alas for that last rosebud which uncloses To Autumn’s languid sun and rain When all the world is on the wane!      Which has not felt the sweet constraint of June,      Nor heard the nightingale in tune. Broad-faced asters by my garden walk,      You are but coarse compared with roses:      More choice, more dear that rosebud which uncloses, Faint-scented, pinched, upon its stalk, That least and last which cold winds balk;      A rose it is though least and last of all,      A rose to me though at the fall.

https://poets.org/poem/october-garden?fbclid=IwAR3kSu15QOVi-dnhrGGv4yPA0XVW63orblH8YBWlZ5stuqf-reOGjSDu1gk

Christina Georgina Rossetti (5 December 1830 – 29 December 1894) was an English writer of romantic, devotional and children's poems, including "Goblin Market" and "Remember". She also wrote the words of two Christmas carols well known in Britain: "In the Bleak Midwinter", later set by Gustav Holst, Katherine Kennicott Davis, and Harold Darke, and "Love Came Down at Christmas", also set by Darke and other composers. She was a sister of the artist and poet Dante Gabriel Rossetti and features in several of his paintings.

https://en.wikipedia.org/wiki/Christina_Rossetti

El Greco (Candia, Crete, 1541-Toledo, 07/04/1614), The Annunciation, 1596-1600, Oil on canvas, 113,8x65,4cm, Museo de Bellas Artes de Bilbao. https://bilbaomuseoa.eus/en/artworks/the-annunciation-69-116/ https://commons.wikimedia.org/wiki/File:El_Greco_-_Anunciación,_1597-1600_(Bilbao).jpg

Museo de Bellas Artes de Bilbao

Museo BBAA Bilbao

@bilbaomuseoa https://twitter.com/bilbaomuseoa/status/1576956322129772545 The Annunciation was a subject that he represented on numerous occasions.

This version, dated between 1596 and 1600, was painted for the altarpiece of the Church of the Incarnation of the Colegio de doña María de Aragón in Madrid. https://twitter.com/bilbaomuseoa/status/1576956328051847168

Museo de Bellas Artes de Bilbao 

Can you guess who is the author of this announcement?

He was born in Candia, capital of the island of Crete, 481 years ago. Below are some clues about his life and work:

 He worked in Venice and then Rome, where he was protected by Cardinal Alejandro Farnesio.

 Attracted by the large decorative sets of El Escorial, it moved to Spain in 1577 and settled permanently in Toledo.

 The Announcement was an issue he represented on numerous occasions.

 This version, dated between 1596 and 1600, was painted for the altar of the Church of the Incarnation of the College of Dona Mary of Aragon in Madrid.

 Like the one from Museo Nacional del Prado , this is a reduced version of the large canvas preserved at the Museo Nacional Thyssen-Bornemisza

Do you have the answer yet?

https://www.facebook.com/bilbaomuseoa/photos/a.779909058739710/5615923575138210/

Schoenberg Institute for Manuscript Studies Manuscript Monday: Ms. Codex 1645 – Technical treatise on the painting of miniatures, Includes information on the reduction of images and mixes of pigments for landscapes, skies, varieties of flowers, skin, faces, drapery, and jewels.

Schoenberg Institute for Manuscript Studies

@sims_mss

Manuscript Monday: Ms. Codex 1645 – Technical treatise on the painting of miniatures

https://twitter.com/sims_mss/status/1576974993434595329

https://schoenberginstitute.org/2022/10/03/manuscript-monday-ms-codex-1645-technical-treatise-on-the-painting-of-miniatures/ Manuscript Monday: Ms. Codex 1645 – Technical treatise on the painting of miniatures

Dot Porter, Curator, Digital Research Services at the University of Pennsylvania Library, offers a video orientation to Ms. Codex 1645, an 18th-century copy of a technical treatise on the painting of miniatures, in print from 1673. Includes information on the reduction of images and mixes of pigments for landscapes, skies, varieties of flowers, skin, faces, drapery, and jewels. Slightly more than half the manuscript (through p. 138) closely matches early printed editions; the remainder of the text presents material from other sources, including preparations and uses of gold leaf, varnish, lacquer, and gold and silver inks, and instructions for marbling paper and tinting parchment. It was written in Nancy, France, in 1744.

You can read the complete record for this document (and find links to digitized copies) on Franklin. You can also download a copy of this video from ScholarlyCommons, the University of Pennsylvania’s open access institutional repository.

https://schoenberginstitute.org/2022/10/03/manuscript-monday-ms-codex-1645-technical-treatise-on-the-painting-of-miniatures/

UNIVERSITY OF PENNSYLVANIA

Penn Library's Ms. Codex 1645 - Technical treatise on the painting of miniatures (Video Orientation)

https://youtu.be/kqibmtZWYYo

38 views Mar 29, 2022

SchoenbergInstitute

1.11K subscribers

The Estée Lauder Companies #ClimateWeekNYC Climate Group on the global effort to address climate change, The Estée Lauder Companies (ELC) has been a leading supporter of Climate Week NYC over the past six years. 

The Estée Lauder Companies

@elcompanies

·

Sep 21

During #ClimateWeekNYC Opening Ceremony, 

@ClimateGroup

 sat down with ELC’s Nancy Mahon to discuss how we aim to meaningfully contribute to the global effort to address climate change. 

Click here to learn how we’re #GettingItDone 

https://twitter.com/elcompanies/status/1572284466361663488

https://www.climateweeknyc.org/news/qa-headline-partner-estee-lauder-companies

Q&A with Headline Partner The Estée Lauder Companies

19th September 2022 Nancy Mahon, Senior Vice President, Global Corporate Citizenship & Sustainability at The Estée Lauder Companies 6 min read

Intro from Helen Clarkson, CEO, Climate Group:

The Estée Lauder Companies (ELC) has been a leading supporter of Climate Week NYC over the past six years. Throughout their involvement, the company has joined together with leaders to convene on key issues related to what the broader beauty industry and global stakeholders must do to help address climate change. In particular, ELC has actively built relationships out of Climate Week events in an effort to collaboratively make the progress this moment demands. This year is no different and we’re grateful to have such a meaningful and engaged partner return as Headline Partner.

Climate Group’s key themes this year are accountability, justice and urgency. ELC has done great work in all of these areas, most recently becoming the first beauty company to join our EV100 initiative last month when they announced their plans to electrify their corporate vehicle fleet by 2030; we’re delighted that ELC will be able to celebrate the five-year anniversary of EV100 this week.

The Opening Ceremony launches Climate Week NYC each year. This is a chance for heads of state, government officials, CEOs and civil society leaders, to share their global outlook on climate change and action. This year, as our Headline Partner, ELC has played a key role in the Opening Ceremony of Climate Week NYC and will join us in The Hub Live to share why they are laser-focused on reducing Scope 3 emissions by working with peers to innovate new solutions.

After the Opening Ceremony, Helen had a chance to sit down one-on-one with ELC’s Nancy Mahon, Senior Vice President, Global Corporate Citizenship & Sustainability, to talk about why the global prestige beauty company is staying humble about what they, and the broader beauty industry, must do to help address and accelerate corporate climate action. They discuss why showing up to the conversation is motivating the company to work harder and faster to make the progress that’s needed to “Get It Done.”

https://www.climateweeknyc.org/news/qa-headline-partner-estee-lauder-companies

[utkutavil]

Taking a break soon!

Mid August updates, last Berlin appearences for some time: 13.08 Recording Sessions at Villa Kuriosum w/ BNSU (duo with Kazehito Seki) and in trio with Thiebault Imm (gtr) and Mia Dyberg (sax) 14.08 Recording Session at Villa Kuriosum, in trio w/ Dirar Kalash(elc) and Joke Lanz (voc) and playing w/ WOW (duo with Morten Minothi Kristiansen) feat. Dr. Nexus at Hangar 49 17.08 playing with BNSU at Villa Kuriosum at Multiversal #85 18.08 DJing under the moniker Blaster Pinky Fraction at Praxis Record Shop 21.08 Playing as BEEATSZ v4.0 at The Workshop on Forsterstr 25.08 w/ TS:PS (first time collaboration with Alex Macia) at A t m o _ s p h ä r e # 8 & Klangkunst LAB at modular+ space 01.09 w/ VVRNGDNG at Arschcholio in Neubrandenburg --- 20.09 BEEATSZ v4.0 at Radio Blackout House, Turin 21.09 w Guajo Eterno (duo w/ Mario Gabola) at 76A, Naples 22.09 w Guajo Eterno at O.P. Jolly Roger, Civitanova 23.09 w Guajo Eterno at Mikasa, Bologna ---- 19-22 Nov Residency with GNOD R&D on board MS Stubniz, Hamburg

[bsquanghuy]

Thuốc Eso-DR 20 tác dụng, liều dùng, giá bao nhiêu? | Tracuuthuoctay | Tracuuthuoctay

TraCuuThuocTay.com chia sẻ: Thuốc Eso-DR 20 điều trị bệnh gì?. Eso-DR 20 công dụng, tác dụng phụ, liều lượng.

BÌNH LUẬN cuối bài để biết: Thuốc Eso-DR 20 giá bao nhiêu? mua ở đâu? Tp HCM, Hà Nội, Cần Thơ, Bình Dương, Đồng Nai, Đà Nẵng. Vui lòng tham khảo các chi tiết dưới đây.

Eso-DR 20

Tác giả: Dược sĩ Hạnh Nguyễn Tham vấn y khoa nhóm biên tập. ngày cập nhật: 1/11/2019

Nhóm thuốc: Thuốc đường tiêu hóa

Dạng bào chế:Viên nang cứng chứa vi hạt bao tan trong ruột

Đóng gói:Hộp 1 lọ 30 viên

Thành phần:

Esomeprazole (dưới dạng Esomeprazole magnesium dihydrate (pellet) 20 mg

SĐK:VN-22410-19

Nhà sản xuất:Hetero Labs Limited – ẤN ĐỘNhà đăng ký:Hetero Labs LimitedNhà phân phối:

Chỉ định:

* Người lớn: Thuốc được chỉ định cho các trường hợp: 

 • Bệnh trào ngược dạ dày-thực quản (GERD) – Điều trị viêm xước thực quản do trào ngược  

– Điều trị dài hạn cho bệnh nhân viêm thực quản đã chữa lành để phòng ngừa tái phát – Điều trị triệu chứng bệnh trào ngược dạ dày-thực quản (GERD) 

• Kết hợp với một phác đồ kháng khuẩn thích hợp để diệt trừ Helicobacter pylori và- Chữa lành loét tá tràng có nhiễm Helicobacter pylori và – Phòng ngừa tái phát loét dạ dày-tá tràng ở bệnh nhân loét có nhiễm Helicobacter pylori.  

• Bệnh nhân cần điều trị bằng thuốc kháng viêm không steroid (NSAID) liên tục- Chữa lành loét dạ dày do dùng thuốc NSAID. – Phòng ngừa loét dạ dày và loét tá tràng do dùng thuốc NSAID ở bệnh nhân có nguy cơ.

 • Điều trị kéo dài sau khi đã điều trị phòng ngừa tái xuất huyết do loét dạ dày tá tràng bằng ��ường tĩnh mạch.

• Điều trị hội chứng Zollinger Ellison

* Trẻ vị thành niên từ 12 tuổi trở lên:

 • Bệnh trào ngược dạ dày thực quản (GERD)

– Điều trị viêm xước thực quản do trào ngược  

– Điều trị dài hạn cho bệnh nhân viêm thực quản đã chữa lành để phòng ngừa tái phát

– Điều trị triệu chứng bệnh trào ngược dạ dày –thực quản (GERD). 

•Kết hợp với kháng sinh trong điều trị loét tá tràng do Helicobacter pylori.

Liều lượng – Cách dùng

Loét tá tràng 20 mg/ngày x 2-4 tuần. Loét dạ dày & viêm thực quản trào ngược 20 mg/ngày x 4-8 tuần. 

Có thể tăng 40 mg/ngày ở bệnh nhân đề kháng với các trị liệu khác. Hội chứng Zollinger-Ellison 60 mg/ngày. 

Dự phòng tái phát loét dạ dày, tá tràng 20-40 mg/ngày.

Chống chỉ định:

Tiền sử quá mẫn với esomeprazole, phân nhóm benzimidazole hay các thành phần khác trong công thức.

Tương tác thuốc:

Esomeprazole ức chế CYP2C19, men chính chuyển hoá esomeprazole. Do vậy, khi esomeprazole được dùng chung với các thuốc chuyển hoá bằng CYP2C29 như diazepam, citalỏpam, imipram, imipramine, clomipramine, phenytoin…, nồng độ các thuốc này trong huyết tương có thể tăng và cần giảm liều dùng.

Tác dụng phụ:

Các phản ứng ngoại ý do thuốc sau đây đã được ghi nhận hay nghi ngờ trong các chương trình nghiên cứu lâm sàng của esomeprazole. Không có phản ứng nào liên quan đến liều dùng. Thường gặp (>1/100,1/1000, 1/10.1000,Các phản ứng ngoại ý được ghi nhận đối với hỗn hợp racemic (omeprazole) và có thể xảy ra với esomeprazole: Hệ thần kinh trung ương và ngoại vị: Dị cảm, buồn ngủ, mất ngủ, chóng mặt. Lú lẫn tâm thần có thể hồi phục, kích động, nóng nảy, trầm cảm và ảo giác chủ yếu ở bệnh nhân mắc bệnh nặng. Nội tiết: nữ hoá tuyến vú. Tiêu hoá: Viêm miệng và bệnh nấm Candida đường tiêu hoá; Huyết học: giảm bạch cầu, giảm tiểu cầu, mất bạch cầu hạt và giảm toàn bộ tế bào máu. Gan: tăng men gan, bênh não ở bệnh nhân trước đó mắc bệnh gan nặng: viêm gan có hoặc không có vàng da, suy gan. Cơ xương: Đau khớp, yếu cơ và đau cơ. Da: Nổi mẩn, nhạy cảm ánh sáng hồng ban da dạng, hội chứng Stevens-Johnson hoại tử biểu bì gây độc (TEN), rụng tóc. Các phản ứng ngoại ý khác mệt mỏi, phản ứng quá mẫn như: phù mạch, sốt, co thắt phế quản, viêm thận kẽ.Tăng tiết mồ hôi, phù ngoại biên, nhìn mờ rối loạn vị giác và giảm natri máu.

Chú ý đề phòng:

Phụ nữ có thai & cho con bú. Cần loại trừ bệnh ác tính trong trường hợp nghi ngờ loét dạ dày.

Thông tin thành phần Esomeprazole

Dược lực:

Thuốc ức chế bơm proton.

Dược động học :

Phân bố Thể tích phân bố biểu kiến ở trạng thái hằng định trên người khoẻ mạnh khoảng 0,22 L/kg thể trọng. Esomeprazole sodium gắn kết 97% với protein huyết tương. Chuyển hóa và bài tiết Esomeprazole sodium được chuyển hóa hoàn toàn qua hệ thống cytochrome P450 (CYP). Phần chính của quá trình chuyển hóa Esomeprazole sodium phụ thuộc vào men CYP2C19 đa hình thái, tạo thành các chất chuyển hóa hydroxy và desmethyl của Esomeprazole sodium. Phần còn lại của quá trình chuyển hóa phụ thuộc vào một chất đồng dạng đặc hiệu khác, CYP3A4, tạo thành Esomeprazole sodium sulphone, chất chuyển hóa chính trong huyết tương. Các tham số dưới đây chủ yếu phản ánh dược động học ở những cá nhân có men chức năng CYP2C19, là nhóm người chuyển hoá mạnh. Tổng độ thanh thải huyết tương khoảng 17L/giờ sau khi dùng liều đơn và khoảng 9L/giờ sau khi dùng liều lặp lại. Thời gian bán thải trong huyết tương khoảng 1,3 giờ sau khi dùng liều lặp lại 1 lần/ngày. Nồng độ và thời gian tiếp xúc (AUC) tăng lên sau khi dùng lặp lại Esomeprazole sodium. Sự tăng này phụ thuộc theo liều và đưa đến kết quả là có mối liên hệ không tuyến tính giữa AUC và liều dùng sau khi dùng liều lặp lại. Sự phụ thuộc vào thời gian và liều dùng này là do sự giảm chuyển hóa ở giai đoạn đầu qua gan và giảm độ thanh thải toàn thân có lẽ do sự ức chế men CYP2C19 của Esomeprazole sodium và/hoặc chất chuyển hóa sulphone. Esomeprazole sodium thải trừ hoàn toàn khỏi huyết tương giữa các liều dùng mà không có khuynh hướng tích lũy khi dùng 1lần/ngày. Sau khi dùng liều lặp lại 40 mg tiêm tĩnh mạch, nồng độ đỉnh trung bình trong huyết tương là khoảng 13,6mcmol/L. Nồng độ đỉnh trung bình của thuốc ở dạng uống tương ứng trong huyết tương là khoảng 4,6mcmol/L. Có thể ghi nhận một tỷ lệ tăng nhẹ (khoảng 30%) về mức tiếp xúc theo nồng độ và thời gian sau khi tiêm tĩnh mạch so với dạng uống. Các chất chuyển hóa chính của Esomeprazole sodium không ảnh hưởng đến sự tiết acid dạ dày. Khoảng 80% Esomeprazole sodium liều uống được bài tiết qua nước tiểu dưới dạng các chất chuyển hóa, phần còn lại qua phân. Ít hơn 1% thuốc dạng không đổi được tìm thấy trong nước tiểu. Các nhóm bệnh nhân đặc biệt Khoảng 1-2% dân số không có men chức năng CYP2C19 và được gọi là nhóm người chuyển hóa kém. Ở các cá nhân này, sự chuyển hoá của Esomeprazole sodium được xúc tác chủ yếu bởi CYP3A4. Sau khi dùng liều lặp lại Esomeprazole sodium 40 mg dạng uống, 1lần/ngày, mức tiếp xúc theo nồng độ và thời gian trung bình ở người chuyển hóa kém cao hơn khoảng 100% so với bệnh nhân có men chức năng CYP2C19 (nhóm người chuyển hóa mạnh). Nồng độ đỉnh trung bình trong huyết tương tăng khoảng 60%. Sự khác biệt tương tự cũng được ghi nhận đối với Esomeprazole sodium tiêm tĩnh mạch. Những ghi nhận này không ảnh hưởng đến liều dùng Esomeprazole sodium. Sự chuyển hóa của Esomeprazole sodium không thay đổi đáng kể ở bệnh nhân cao tuổi (71-80 tuổi). Sau khi dùng liều đơn Esomeprazole sodium 40 mg dạng uống, mức tiếp xúc theo nồng độ và thời gian ở phụ nữ cao hơn nam giới khoảng 30%. Không ghi nhận có sự khác biệt về mức tiếp xúc theo nồng độ và thời gian giữa các giới tính sau khi dùng liều lặp lại 1lần/ngày. Sự khác biệt tương tự cũng được ghi nhận khi dùng Esomeprazole sodium đường tĩnh mạch. Những ghi nhận này không ảnh hưởng đến liều dùng Esomeprazole sodium. Sự chuyển hóa của Esomeprazole sodium có thể bị suy giảm ở bệnh nhân rối loạn chức năng gan từ nhẹ đến trung bình. Tốc độ chuyển hóa giảm ở bệnh nhân rối loạn chức năng gan nặng, dẫn đến làm tăng gấp đôi mức tiếp xúc theo nồng độ và thời gian của Esomeprazole sodium. Vì vậy, không dùng quá liều tối đa 20 mg ở bệnh nhân rối loạn chức năng gan nặng. Esomeprazole sodium hoặc các chất chuyển hóa chính không có khuynh hướng tích lũy khi dùng 1lần/ngày. Chưa có nghiên cứu nào được thực hiện trên bệnh nhân giảm chức năng thận. Vì thận chịu trách nhiệm trong việc bài tiết các chất chuyển hóa của Esomeprazole sodium nhưng không chịu trách nhiệm cho sự đào thải thuốc dưới dạng không đổi, người ta cho là sự chuyển hóa của Esomeprazole sodium không thay đổi ở bệnh nhân suy giảm chức năng thận.

Tác dụng :

Esomeprazole sodium là dạng đồng phân S-của omeprazole và làm giảm sự bài tiết acid dạ dày bằng một cơ chế tác động chuyên biệt. Thuốc là chất ức chế đặc hiệu bơm acid ở tế bào thành. Cả hai dạng đồng phân R-và S-của omeprazole đều có tác động dược lực học tương tự. Vị trí và cơ chế tác động Esomeprazole sodium là một chất kiềm yếu, được tập trung và biến đổi thành dạng có hoạt tính trong môi trường acid cao ở ống tiểu quản chế tiết của tế bào thành, tại đây thuốc ức chế men H+K+-ATPase (bơm acid) và ức chế cả sự tiết dịch cơ bản lẫn sự tiết dịch do kích thích. Tác động lên sự tiết acid dịch vị Sau 5 ngày dùng liều uống Esomeprazole sodium 20 mg và 40 mg, độ pH trong dạ dày > 4 đã được duy trì trong thời gian trung bình tương ứng là 13 và 17 giờ trong vòng 24 giờ ở bệnh nhân trào ngược dạ dày thực quản có triệu chứng. Tác động này giống nhau bất kể Esomeprazole sodium được dùng đường uống hoặc đường tĩnh mạch. Khi dùng AUC như là một tham số đại diện cho nồng độ thuốc trong huyết tương, người ta đã chứng minh được có mối liên hệ giữa sự ức chế tiết acid với nồng độ thuốc và thời gian tiếp xúc sau khi dùng Esomeprazole sodium dạng uống. Tác động trị liệu của sự ức chế acid Khi dùng Esomeprazole sodium 40 mg dạng uống, khoảng 78% bệnh nhân viêm thực quản do trào ngược được chữa lành sau 4 tuần và 93% được chữa lành sau 8 tuần. Các tác động khác có liên quan đến sự ức chế acid Trong quá trình điều trị bằng thuốc kháng tiết acid dịch vị, nồng độ gastrin huyết thanh tăng đáp ứng với sự giảm acid dịch vị. Tăng số tế bào ELC có lẽ do tăng nồng độ gastrin huyết thanh đã được ghi nhận ở một số bệnh nhân khi điều trị dài hạn với Esomeprazole sodium dạng uống. Sau thời gian dài điều trị bằng thuốc kháng tiết acid dịch vị, nang tuyến dạ dày được ghi nhận xảy ra tương đối thường xuyên hơn. Những thay đổi này, là kết quả sinh lý của sự ức chế mạnh lên tiết acid dịch vị, thì lành tính và có thể phục hồi được.

Chỉ định :

Esomeprazole sodium được chỉ định trong bệnh trào ngược dạ dày-thực quản trên bệnh nhân viêm thực quản và/hoặc có triệu chứng trào ngược nặng như là một liệu pháp thay thế cho dạng uống khi liệu pháp dùng qua đường uống không thích hợp.

Liều lượng – cách dùng:

Thuốc uống: 

– Loét tá tràng 20 mg/ngày x 2-4 tuần.  

– Loét dạ dày & viêm thực quản trào ngược 20 mg/ngày x 4-8 tuần. Có thể tăng 40 mg/ngày ở bệnh nhân đề kháng với các trị liệu khác.

– Hội chứng Zollinger-Ellison 60 mg/ngày.

– Dự phòng tái phát loét dạ dày, tá tràng 20-40 mg/ngày.

Thuốc tiêm:

Bệnh nhân không thể dùng thuốc qua đường uống có thể điều trị bằng dạng tiêm với liều 20-40mg, 1 lần/ngày.

Bệnh nhân bị trào ngược thực quản nên được điều trị với liều 40mg, 1 lần/ngày.

Ðể điều trị triệu chứng bệnh trào ngược, bệnh nhân nên được dùng liều 20mg, 1 lần/ngày. Thời gian điều trị qua đường tĩnh mạch thường ngắn và nên chuyển sang dùng thuốc đường uống ngay khi có thể được. 

Cách sử dụng 

 Ðường tiêm: 

Liều 40mg Dung dịch pha tiêm nên được tiêm tĩnh mạch trong khoảng thời gian tối thiểu 3 phút. 

Liều 20mg: Nửa phần dung dịch pha nên được tiêm tĩnh mạch trong khoảng thời gian tối thiểu 3 phút. Nên loại bỏ phần dung dịch không sử dụng. 

Ðường tiêm truyền: 

Liều 40mg: Dung dịch pha tiêm nên được truyền tĩnh mạch trong khoảng thời gian từ 10 đến 30 phút. 

Liều 20mg: Nửa phần dung dịch pha nên được truyền tĩnh mạch trong thời gian tối thiểu 10-30 phút. Nên loại bỏ phần dung dịch không sử dụng. 

Trẻ em: Esomeprazole sodium không nên dùng cho trẻ em vì chưa có dữ liệu. Người suy chức năng thận: Không cần điều chỉnh liều ở bệnh nhân suy chức năng thận. Do kinh nghiệm điều trị cho bệnh nhân suy thận nặng vẫn còn hạn chế, nên thận trọng khi dùng thuốc trên các bệnh nhân này. 

Người suy chức năng gan: Không cần điều chỉnh liều ở bệnh nhân suy chức năng gan từ nhẹ đến trung bình. Ðối với bệnh nhân suy gan nặng, không nên dùng quá liều tối đa 20 mg Esomeprazole sodium mỗi ngày. 

Người cao tuổi: Không cần điều chỉnh liều ở người cao tuổi. 

Hướng dẫn sử dụng: 

Tiêm: Dung dịch tiêm được pha chế bằng cách thêm 5 mL dung dịch NaCl 0,9% dùng đường tĩnh mạch vào lọ thuốc chứa Esomeprazole sodium. Dung dịch tiêm sau khi pha trong suốt và không màu hoặc vàng nhạt. Sự phân hủy dung dịch pha chế phụ thuộc vào độ pH cao và vì vậy thuốc chỉ nên pha với dung dịch NaCl 0,9% dùng đường tĩnh mạch. Dung dịch sau khi pha không nên pha trộn hoặc dùng chung một bộ dây truyền với các thuốc khác. Dung dịch đã pha nên được kiểm tra bằng mắt thường xem có phần tử lạ và biến màu trước khi dùng. Chỉ sử dụng dung dịch trong suốt. Dung dịch đã pha nên được dùng trong vòng 12 giờ sau khi pha. Không bảo quản ở nhiệt độ lớn hơn 25 độ C. Dung dịch đã pha nên được tiêm tĩnh mạch trong khoảng thời gian tối thiểu là 3 phút. Nên dùng nửa thể tích pha nếu chỉ dùng 20mg. Phần dung dịch không sử dụng nên được loại bỏ. 

Tiêm truyền: 

Dung dịch tiêm truyền được pha chế bằng cách hòa tan thuốc Esomeprazole sodium chứa trong 1 lọ với một thể tích lên đến 100 mL dung dịch NaCl 0,9% dùng đường tĩnh mạch. Dung dịch tiêm sau khi pha trong suốt và không màu hoặc vàng nhạt. Sự phân hủy dung dịch pha chế phụ thuộc vào độ pH cao và vì vậy thuốc chỉ nên pha với một thể tích xác định dung dịch NaCl 0,9% dùng đường tĩnh mạch. Dung dịch đã pha không nên pha trộn hoặc dùng cùng một bộ dây truyền với các thuốc khác. Dung dịch đã pha nên được dùng tách biệt với các thuốc khác. 

Dung dịch đã pha nên được kiểm tra bằng mắt thường xem có phần tử lạ và biến màu trước khi dùng. Chỉ sử dụng dung dịch trong suốt. Dung dịch đã pha này nên được dùng trong vòng 12 giờ sau khi pha. Không bảo quản ở nhiệt độ lớn hơn 25 độ C. Dung dịch đã pha nên được tiêm truyền tĩnh mạch trong khoảng thời gian từ 10 đến 30 phút. Nên dùng nửa thể tích pha nếu chỉ dùng 20mg. Phần dung dịch không sử dụng nên được loại bỏ. 

* Không nên dùng thuốc này cùng với các thuốc khác ngoại trừ các thuốc được đề cập đến trong phần Hướng Dẫn Sử Dụng.

Chống chỉ định :

Tiền sử quá mẫn với hoạt chất chính Esomeprazole sodium hoặc với các chất khác thuộc phân nhóm benzimidazoles hoặc bất kỳ tá dược nào của thuốc này.

Tác dụng phụ

Các phản ứng ngoại ý do thuốc sau đây đã được ghi nhận hay nghi ngờ trong các thử nghiệm lâm sàng của Esomeprazole sodium dùng đường uống hoặc đường tĩnh mạch và sau khi lưu hành dạng uống của thuốc trên thị trường. Thường gặp (> 1/100, Nhức đầu, đau bụng, tiêu chảy, đầy hơi, buồn nôn/nôn, táo bón. Ít gặp (> 1/1000, Viêm da, ngứa, nổi mề đay, choáng váng, khô miệng, nhìn mờ. Hiếm gặp (> 1/10.000, Phản ứng quá mẫn như phù mạch, phản ứng phản vệ. Tăng men gan. Hội chứng Stevens Johnson, hồng ban đa dạng, đau cơ. Các phản ứng ngoại ý sau đây đã được ghi nhận đối với đồng phân racemic (omeprazole) và có thể xảy ra với Esomeprazole sodium: Hệ thần kinh trung ương và ngoại vi: Dị cảm, buồn ngủ, mất ngủ, chóng mặt. Lú lẫn tâm thần có thể hồi phục, kích động, nóng nảy, trầm cảm và ảo giác chủ yếu ở bệnh nhân mắc bệnh nặng. Nội tiết: Nữ hóa tuyến vú. Tiêu hóa: Viêm miệng và bệnh nấm Candida đường tiêu hóa. Huyết học: Giảm bạch cầu, giảm tiểu cầu, mất bạch cầu hạt và giảm toàn bộ tế bào máu. Gan: Bệnh não ở bệnh nhân trước đó mắc bệnh gan nặng; viêm gan có hoặc không có vàng da, suy gan. Cơ xương: Ðau khớp, yếu cơ. Da: Nổi mẩn, nhạy cảm ánh sáng, hoại tử thượng bì nhiễm độc (TEN), rụng tóc. Các phản ứng ngoại ý khác: Mệt mỏi. Phản ứng quá mẫn như: sốt, co thắt phế quản, viêm thận kẽ. Tăng tiết mồ hôi, phù ngoại biên, rối loạn vị giác và giảm natri máu. Tổn thương thị giác không phục hồi được đã được ghi nhận trong một số rất hiếm trường hợp bệnh nhân mắc bệnh trầm trọng đã dùng omeprazole đường tĩnh mạch, đặc biệt khi dùng liều cao, nhưng vẫn chưa xác định mối quan hệ nhân quả giữa việc dùng thuốc và biến cố ngoại ý này.

Lưu ý: Dùng thuốc theo chỉ định của Bác sĩ

Nguồn tham khảo drugs.com, medicines.org.uk, webmd.com và TraCuuThuocTay.com tổng hợp.

Cần tư vấn thêm về Thuốc Eso-DR 20 tác dụng, liều dùng, giá bao nhiêu? bình luận cuối bài viết.

Tuyên bố miễn trừ trách nhiệm y tế

Nội dung của TraCuuThuocTay.com chỉ nhằm mục đích cung cấp thông tin về Thuốc Eso-DR 20 tác dụng, liều dùng, giá bao nhiêu? và không nhằm mục đích thay thế cho tư vấn, chẩn đoán hoặc điều trị y tế chuyên nghiệp.

Chúng tôi miễn trừ trách nhiệm y tế nếu bệnh nhân tự ý sử dụng thuốc mà không tuân theo chỉ định của bác sĩ.

Vui lòng liên hệ với bác sĩ hoặc phòng khám, bệnh viện gần nhất để được tư vấn.

Đánh giá 5* post

The post Thuốc Eso-DR 20 tác dụng, liều dùng, giá bao nhiêu? appeared first on Tra Cứu Thuốc Tây.

from Tra Cứu Thuốc Tây https://ift.tt/3g0cuTn Bác sĩ Nguyễn Quang Huy Dẫn nguồn từ Tra Cứu Thuốc Tây https://tracuuthuoctay.com/thuoc-eso-dr-20-tac-dung-lieu-dung-gia-bao-nhieu/ from Bác sĩ Nguyễn Quang Huy https://ift.tt/2E3qhvd Dẫn nguồn từ Bác sĩ Nguyễn Quang Huy https://bsquanghuy.blogspot.com/2020/08/thuoc-eso-dr-20-tac-dung-lieu-dung-gia.html

[karsrobles]

Taipei Bang Bang! #MadamInTaiwan #MadamTravels #taiwan #elc #labs #fujifilm_xseries 🇹🇼👆 (at 貓空纜車 Maokong Gondola)

[evilisk]

In Arc the Lad 2, Elc is capable of using swords, spears or axes. Despite the spear being Elc’s default weapon, as well as his signature weapon in every appearance afterwards, Arc 2 always portrays Elc using the sword during action cutscenes. Even the Elc clones (during the Chimera Labs segment) are shown with swords rather than spears.

[openstudiofourworks]

https://soundcloud.com/kate-land-178685799/grocery-flatline

Collaborative sound work with Madison Agnew. 

Made in the sound lab class with Daniel using audio recorded in the local grocery store using Zoom recorders hired from the ELC. 

Already quite familiar with using Audition but was nice to formally learn how to utilise the program’s features, especially the effects.

 I like the effect of the ‘heartbeat’ but would like to learn how to improve upon the sounds quality, and perhaps remove the white noise in the background.

[studylifeusa]

Your Ambition Can't Wait at Drexel University

Drexel University is one of America’s 15 largest private universities and has been ranked among the nation’s Top 100 best universities for the past five years. Drexel is best known for starting one of the nation’s largest and oldest cooperative-education programs. Through the Drexel Co-op program, students gain on-the-job training with employers worldwide while earning their degree.

Drexel University is located in one of the nation’s first and largest cities – Philadelphia which is located halfway between New York City and Washington, D.C.

The English Language Center offers courses in academic English, Business English, TOEFL/IELTS Test Preparation, and an undergraduate conditional admission program. Courses are offered year round for beginner to advanced level students. All Drexel ELC instructors hold an advanced degree and have years of training and teaching experience.

The mission of the Drexel University English Language Center is:

to provide the highest quality English language instruction and support services to English language learners;

to promote the practice and scholarship of English language teaching in an environment of integrity and respect;

to provide leadership in the areas of intercultural understanding and global cooperation; and

to support the mission of Drexel University in preparing and supporting international students to participate fully in the university community.

Why is Drexel ELC a great place to study English?

11-week and 6-week Intensive English programs year round

Global Business English Pre-MBA programs for university graduates and professionals

Drexel International Gateway, an undergraduate foundation year program for conditional admission to Drexel University

American Cultural Connections ™ including weekly activities on the Drexel campus and in or around the city of Philadelphia

Scholarship opportunities for continuing students

Conversation Network, an opportunity for language exchange between American and international students  

On-campus dormitory, student residence, and homestay accommodations

TOEFL preparation  

IELTS testing and test preparation  

Communications courses for medical professionals

You’ll get

Small classes so you get personal attention

Instructors with advanced degrees and years of teaching experience

Placement tests for Speaking and Writing levels at the start of each term

An orientation program before classes start

Certificates for successful completion of each full or half term.

Innovative classroom technology and an interactive, multi-media language lab

Leadership training opportunities

Visa counseling

Academic advising for graduate and undergraduate university study in the U.S.

Apply Now through our StudyUSA+ platform.

StudyUSA+ is ready to take you through the entire application, admission and enrollment process with one application form and you can do it in one place.

Drexel University  is waiting for your application. Are you ready? Let’s get started with StudyUSA+.

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