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hazinhoodies · 5 years

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No Love Lost (Part 1)

Harrison Osterfield x CF!Reader

A/N: uh hi. so this is a lot. this was going to be a one-shot originally but then it hit 15k words so here’s some of that. I did as much research into cystic fibrosis as i could (thats what cf means btw). Thanks to @loverholland who helped me edit this (and future parts). Also this is my submission for @starksparker summer writing challenge. I had the prompt of “I know you. What’s wrong” and its used pretty bad but this will make up for it hopefully. its a whole mess of aus. there some fuck boy in there, some best friend. brace for impact.

Word Count: 3.2k

Warnings: talk of death, talk of hospitals, talk of sickness, swearing, messing with tenses, a ridiculous amount of parentheticals (yes they’re supposed to be there), cheesy writing

Harrison was sweet. You had to admit it. One of the nicest people you’d ever come by. He was your best friend all throughout school, he stuck by you through all the coughing fits, your plethora of medicines, and the multiple times you’d caught bronchitis or something along those lines, not to mention all the other things that come with being a teen in high school; drama, puberty, stress. You were insanely thankful that he put up with all his own problems as well as yours, health or otherwise, and everything that came with having cystic fibrosis.

You were diagnosed at five, after the third time you’d caught pneumonia. Most people are diagnosed before the age of two but either a) you weren’t screened for it at birth or b) your doctors missed something. Just your luck.

You didn’t really know what it meant at first. Just that now you had to take these medicines, pills, and use inhalers (which hurt on bad days). Your favourite part was always the gummy vitamin that you had to -no, got to- take. You heard your mom talking about how important it was that you cleared your airway every day and that you did some of, if not all, the exercise the doctors wanted you to take. They made your lungs burn.

Your mother, however, felt guilty. She blamed herself for your sickness, but her guilt was helping no one affected. She should’ve known that you were growing too slowly and that your breathing problems weren’t normal. She feels horrible.

But if she had and you’d been diagnosed earlier or later or exactly when you were, you would still have cystic fibrosis.

You started to understand what it was at the age of eleven after you’d decided to research it yourself. You knew better than to WebMD it. Long since being diagnosed, you weren’t looking for a cure, just an understanding of what this meant for you.

You found out too much. Things that you were certain a normal 11 year old wouldn’t know about. But you weren’t normal. Anything but.

You found out that the average person with cystic fibrosis died at the age of 37, it’s most common in Northern Europe and least common in Africans and Asians. Although not recognized until the 1930s, certain aspects of cystic fibrosis were identified as early as 3,000 BC, likely due to the migration of people, gene mutations and nourishment. One in Four people have cystic fibrosis. About eighty percent of people with cystic fibrosis die from it. There’s no known cure, if there is one at all.

Your first (and only, so far) double lung transplant happened about a year later. You remember the feeling of knowing something was wrong too vividly. Headed down the stairs, your twelve year old self had already run through your extensive morning routine but you couldn’t shake the feeling of something caught in your lungs. You had to breathe through your mouth to feel like you were getting anywhere near enough oxygen.

“Have you cleared your airways yet” Your mother had asked upon hearing how rough your voice sounded when combined with how much your chest heaved when you breathed. You nodded and she asked you to go to it again. It was on your way back down the steps when it had become instantly more difficult to breathe. Calling for your mom, your voice was weak and wheezed its way through the words. It felt like you were suffocating. You gripped the stair railing tight in your hand as you felt your vision start to tunnel. With whatever luck you still had, you made it to the bottom of the stairs without collapsing and she rushed you to the hospital.

You don’t know what they did to make it better temporarily but you remember being hooked up to all sorts of antibiotics to slow the mucus build up while they found a pair of lungs for you. A month later and they had found a pair. You spent the next while in the hospital from the surgery while the doctors monitored you.

Lung transplants either work or they don’t. There’s no in between. No ‘it works but could be better’. They do, or they don’t.

Your mother would tell you when you were older that yours almost didn’t work. You almost didn’t wake up, but you wouldn’t remember any of it when she told you so.

You were overjoyed when you got to go back to school, you knew you weren’t healed, you still had cystic fibrosis, but you were doing better. That’s when you met Harrison.

With Harrison, you felt like you could be somewhat. He didn’t know about your CF at the time, you held it back to not drive him away. You suppressed coughs as much as you could. He was good though. A good person, a kind soul. So good that when you were with him, you were normal. You felt like a normal kid. You forgot about the multiple inhalers that sat on the bathroom counter and the bottles of pills next to them. You forgot about the doctors, and your enzymes or lack thereof. With Harrison, you forgot you were dying.

He started to get curious when you were missing school a lot and played it off as a cold when you would cough a lot at one time, but Harrison isn’t an idiot and you’re his friend; he knew something was up.

So you told him. You told him you had cystic fibrosis. He seemed confused so you continued on. You explained that while it also affects your pancreas, intestines, and kidneys, it meant your lungs were weak and prone to infection. Mucus builds up inside your lungs and other parts of your respiratory system. You told him that if your lungs get worse then you’ll likely need a transplant.

He nodded along and promised that he understood but you knew he didn’t fully understand what it meant, just as you had.

You didn’t tell him you were dying.

Not then. Not at all.

He’d found out on his own that it meant you were dying. You never asked how. The pair of you were in your living room at the age of fourteen, in the middle of a game of Mario Party. The computer Boo was winning. You could tell that something was bothering him but weren’t sure if it was something to ask about, you did anyway.

“Haz? What’s bothering you?” You spoke as the Luigi on the screen moved 6 spaces.

“Nothing, I’m fine” He stared distantly towards the screen, it’s more likely he’s looking past it.

“And lying. I know you. What's wrong?" No response. "Harrison, tell me” You refused to press any buttons, letting the die on the screen roll above your characters head until he gave you an answer.

Harrison looked down into his lap, fumbling with some of the buttons on the remote. His voice comes out small and meek, “You’re dying”

“No, I’m not,” Some weird instinct told you to lie about it and protect his feelings, but the glimmer of hope he had when he looked at you made you wish that you hadn’t said that. “I mean, I am. But I’m not bad” You hesitate on ‘bad’, unsure of how you want to phrase things. You knew you had to be careful of what you say. “I’m not even on a transplant list yet,” His expression shifted to worry, “It’s a good thing” He somewhat relaxed. “It means that I’m managing it well. And I am. I take care of myself, take all the medication I need to. It’s a lot but I do it”

The look on his face made your heart go soft. Somewhere between worry and relief, happy and sad.

“I’m sorry I didn’t tell you sooner” You whispered, your gaze falling to the floor. You felt bad about telling him, that’s for sure. But for once you wanted to be normal.

“It’s okay,” Harrison’s voice was almost as quiet as yours, the overly happy game music playing in the background (it really didn’t help with the mood). He looked over at you and your expression made his heartbreak. “Hey,” he grabbed your attention, “This doesn’t change anything. No love lost, yeah?”

You nodded. “What I meant is that you don’t have to worry about me” That was the end of it. You rolled a five.

The next few months saw a shift in your relationship. It’s not that you spent any less time together, quite the opposite actually. Harrison wanted to spend so much time with you, most of which consisted of the two of you doing anything either of you could think of. More games of Mario Party (you won more often, he’d say he let you but he definitely didn’t), going out for food, bowling, laser tag, you name it.

He also took care of you. No matter how much you said you didn’t need it and you didn’t want to bother him, you’d get text messages at the same time every day asking if you’d taken your enzymes, or cleared your airways, or if you were close to running out of anything.

Harrison was sweet. He was sweet to you and you couldn’t be more thankful.

High school came and the world watched on as the two of you grew closer than ever. He was there as soon as he could be whenever you were in the hospital and even if you weren’t, he was at your house or you were at his as much as you could be.

Looking back, you weren’t sure how you didn’t see it.

While you were still Harrison’s best friend, he spent time with a lot of other girls. You weren’t dumb. You saw the way they looked at him. Their looks were anything from ogling or as if he was the moon. Their never-ending night light. The one that lit up the dark for them.

It was cheesy and sometimes (usually) gross, but he never looked at them that way. Even while his arm was wrapped around them in the halls he was either making some joke towards you (you’d say he was bullying you, but you weren’t that hurt) or laughing at something someone else had said or done.

Every two weeks there was a different girl on his arm. It didn’t really make sense to you. He was so nice and caring towards you but then these girls that he claimed to have feelings for barely got a second glance from him. Even still, part of you wanted to be in their position, if only for the title that came with it.

You fell in love with Harrison slowly. Like when you come home late and don’t want to wake anyone, so you shut the door precariously, even the small click after it’s shut is too loud. Or like waiting for a flower to grow. Checking on it until you saw the first sprout and then the first leaf.

Your sudden realization, your ‘click’, was when you’d heard one of the girls talking about him after they’d ended things. You weren't sure if you could call it a breakup, we’re they even official? Who knows.

Water ran from the tap in the bathroom as you washed your hands, you couldn’t help but listen to the conversation she was having on the far side of the room. It was whispered and sobbed but you still managed.

“What’d he say?” Her friend, you thought her name was Olivia, places a comforting hand on her shoulder.

“He just said he didn’t feel anything for me anymore” Harrison ex-thing, her name was Erica, (she was one of the “you are the moon” starers) barely got out the last word before sobs racked her body, her upper body and torso shook forcefully with each one. She was really hurt. “Said that there was something about someone else. I don’t get it. It was three weeks how could there be someone else”.

If it was three weeks then why are you so worked up over it? You fought not to roll your eyes.

“Erica, I told you that he was a bad idea. I told you that he’d hurt you. And you still…” Olivia trailed off with a sigh. Some best friend.

“I don’t know. Maybe I thought I could change him or something. Fuck, I don’t know. He’ll always be a fuckboy I guess. Can’t wait to see who he’s got next week” Sarcasm drenched her words. She sniffled, wiping her eyes.

You dried off your hands and left the bathroom.

It hurts to hear people talk so horrendously about your best friend. That wasn’t the Harrison that you knew, the Harrison you knew was gentle and caring and wore his heart on his sleeve. What about you made him that different?

Harrison came over that night, you helped him with his English paper and then the two of you retreated to doing your own things on your phones. He laid on your bed and you used his stomach as a pillow, lying perpendicular to him. Your legs hung off the bed a little, but you didn’t care.

The room was silent for at least fifteen minutes with the exception of the odd chuckle followed by the other asking to look at whatever it was they laughed at. That was until you piped up. Your mindless scrolling only lasts so long before you fall into your own thoughts.

“Heard Erica talking about you in the bathroom today” You let your hand fall to your chest, phone facedown against your sternum. Harrison didn’t really talk about the girls he was involved with. At least not with you. You weren’t sure why but never pressed.

“Yeah? What’d she say?” His eyes didn’t leave his phone.

“She was talking to Olivia, I think it was Olivia. The one who sits next to Tom in English”

“Yeah, Olivia” Harrison confirmed.

“Yeah her. And she -Erica- was saying about how you broke up with her and said that there was someone else. And then Olivia said something about how she warned her not to go for you because you’re a bad idea and you’d only hurt her and shit like that”

“Sounds like Liv” Harrison chimes in.

“Then Erica said that she thought she could change you or something like that? I don’t know. It was just weird to hear them talk so bad about you when what I see is the polar opposite” You started your scrolling again.

“People talk Y/N. She was just upset I guess. That’s okay” You nodded and there was a moment of silence

“Just out of curiosity. Why do you go through girls so fast?”

“I just don’t feel anything with them really. I know what I want, and sadly it’s things that I don’t think they’d ever be able to give, or have, or be”

“What do you want?” Your question threw him off guard and he had to pause for a second.

“I want pure love. It’s not driven by lust. A kind of love where I don’t have to worry about what I look like or how I act around them because I know they’ll love me just the same. One where we have electric conversations one moment and then the next we’re in silence but it’s fine. Because it’s comfortable. I want to have a connection. I want the kind of love where you’d die for the other person. I’d die for a love like that. And it’s something that I don’t think I could get from Erica or Megan or Hannah. No matter how long we’re together”

“But you’re not even going to stick around long enough to see if there is all that with them?”

“No. I know it makes me sound like an asshole but I know what I want. I just have to wait until that love realizes what they want”

You thought for a moment. Maybe it made sense? In some weird, twisted, ‘i’m an asshole but don’t want you to think so’ sort of way. “Okay” You trailed off.

“Also we were only a thing for like three weeks why is she this upset”

“That’s what I thought!” The two of you laughed and settled back into a comfortable silence.

You’d since learned to trust what you knew about Harrison, disregarding parts of what was said that night. He was kind, and took care of you, and cared deeply about so many things. You knew about his reputation, but you didn’t care. He was your best friend, and what kind of friend would you be if you changed your opinion based on what other people said. Certainly better than ones who date the guy who broke your heart (*cough* Olivia, *cough cough*) The same one who warned you not to date him.

And sure enough, the following week, Olivia and Harrison were together.

Olivia was the longest he’d been with someone that you knew about. A whole eight weeks was a record for Harrison. It almost made you think that maybe he was capable of finding love on his own. And that made you happy. Happy for him.

Then there was that damn click. That fucking leaf. The one that made you sad when you saw them in the halls, her hand in his. The same one that made your stomach drop when he'd kiss her cheek before class.

Although his time never wavered with you, you couldn't help but wish it was you under his arm. With his lips against your skin.

High school ended, Harrison went on to drama school. It fit, he’d always been dramatic (haha very funny Y/N) but you were proud of him for pursuing his dream of acting. You’d gone onto university as well. Although the two of you didn’t see each other nearly as much, you were still his best friend, and him yours. The texts to take your meds had changed from whenever you had to take one to only every morning, and the two of you would talk that night.

June Twenty-Second. You’d finished all your exams two months ago. Still riding on the high of being a university graduate, you didn’t expect for it to drop so fast.

You were put on the transplant list your sophomore year of university. But you were getting worse, you’d moved up significantly since being put on. June Twenty-Second is when your doctor told you that if you couldn’t get one of the next few lungs, you’d be out of time.

When you’d discovered that you were dying when you were eleven, you struggled to cope with it. Slowly but surely, you’d learned to accept that you couldn’t live forever, and if you’d been asked a month ago how you felt about death, you know how you would have answered. You would have said that it’s a part of life. That every journey has its end. You would have said that no matter what you did you couldn’t change anything and you were okay with dying. Maybe it was your time.

But when your doctor finally, officially tells you that they don’t know if they'll get you a pair of lungs in time, one thing comes to mind.

I’m not ready for this.

Immediately followed by another thought.

Harrison

Tags:

haz tags:

@summernykole @hjosterfield @imagines-andshizz @thequeensardine @artemisiaarm @sincerelymlg @butithasntkilledyouyet @bitchymathematician @ixchel-9275 @honeyyhuggs @nedthegay @ohyouremymedicine @awkwardfangirl2014 @parkerpeterholland @screeching-student-unknown

@osterfieldholland01 @happymagicbee @headsup-itsmostlypeter @starlightfound @spideyyypeter @empressdreams @isabellyduh

Others who i think might enjoy or hate me for it (or already do)

@wazzupmrstark @parkerpuffwrites @parrkerspeters @nnatasha @lamptracker (really i just want you to read this)

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valgasnewsthings · 3 years

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System scleroderma is golden water helps.

A system scleroderma is a most hard disease of connective tissue and disease attacks on 45/60 y.old and women's are often sick,than males on 7 times. And which are reasons, which cure methods are today, do herbs effective in scleroderma?And on these on an other questions is answered to us doctor Mitrohina.

As a evidenced,that system diseases for connective tissue are deep destroys happening of immune status,as causing in development for autoimmune processes as immune system reactions as directing against an own organism.And diseases of connective tissue as systemic diseases are lupus,sjogren, Sharp, rheumatic polymyalgia, recidiving polychondritis, panniculitis, Bechchet, vasculitis due for raw factors as infection, genetical, endocrine, environment external, as stress, infection, over cooling, injury. As surrounding factors are curing a hide displaying disease or being in a a genetical predisposition , but a trigger mechanism for systemic diseases for connective tissue. And systemic scleroderma is progressing diseases of connective tissue and small vessels,characterizing with a fibrosis sclerotic changing a skin and connective tissue and inside organs as lungs, heart, gastric, kidneys.

And base symptoms for scleroderma are skin as of hard edema, on the wrists of hands and face with a changing her colour and high peeling.

Vessels are Reynaud s syndrome ,as with a trophic vessel changes as destroying a warm perception, and cold, displaying ulcers , necrosis.

Joints as aches in muscles and joints, fibrosis contractures, muscles atrophy, changes in bones.

Gastric as swallowing bad, weak peristaltic, as casting of stomach contain in gullet, narrowing gullet, small bowel inflammation, and particularly bowel s obstruction.

Breath organs as overgrowing a connective tissue in lungs, and inflammation in lungs tissues and pleura.

Heart as inflammations overgrowing connective tissue in heart as cardio fibrosis lead to myocard ishemia, heart rhythm bad, and conductivity.

Kidneys are inflammations and fibrosis changes.

Endocrine and nerves as destroy function for thyroid gland as hypothyreosis,rare are sex glands with displaying impotence, nerve tissues damages as polyneuropathy.

A picture is a not funny, and here is a not just an all.

As for a systemic scleroderma a lowering body mass on ten kg and more, fever, as subfebrile .

And laboratory diagnosis for a vessel scleroderma are blood tests as clinical and biochemical analysis, and definition for immune status.

And cure here is complex and hard,as on every concrete case prescribing with individual selecting remedies and theirs doses.As anti fibrosis and anti inflammatory remedies and vessel, immune depressants, physiotherapy, exercises, massage, surgery, as plastic skin surgery also adding.

Here is a letter by Maria,that on 68 y.old with systemic scleroderma,does am allow use exercises as squats, push-ups and etc, does my joints are not more destroy?

Yes you can and need,as a complex for exercises will prescribe your doctor as selecting individuality as depending from a kins and level of damage of every from joints.

And traditional question here about herbs for cure.

As a reasons for much reasons in which scleroderma displaying a forming destroying as importance protein is collagen,which a base for connective tissue.

And in biochemical reactions of collagen synthesis are taking part ions of a few metals.As cuprum is a base for a part ferment lysyl oxidase ,which sewing fib rilles of collagen in one tissue , but a golden catharizing these processes. And in a few cases remedies with cuprum and golden are lead to relieving a condition in patients,and these remedies in India are 2000 activity using is golden water.As for a her cooking using 999 gold sample as on 5gr weight, or two pieces on one gr and here is not weight importance, here is a size for top metal as in 2 pieces one gr in size ,like in one 5 gr piece. As golden put in enamel or glass heat -resistance cup,adding 200 ml. of drinking water and put on fire. Warm till temperature for water boiling and boil till a half water boils away. And receiving infusion cool,use on 30/50 ml. everyday till a stable improving beginning and if needing a golden water course is to repeat.

And if golden pieces you had not, thus use a golden ring wedding , as an other jewel items, as in a manufactured of which used soldering by jewellery soldering are not matching,they are having toxic substances. As ring put on the one day in vinegar, wash after a drinking water and after cooking same.And drink. And difference ,that a ring before boiling every time put in vinegar,as for wash by him of a golden alloy are unnecessary ligatures. As in other receiving solution and his using is nothing difference from a data described.

And golden water is fatal affecting on the tumor cells ,and this is recommending as for additional remedy for preventing metastasizing after oncology surgery. Ions of golden are not having contraindications. And all alternative cure, as a additional to the base cure by a doctor,and not changes his.

A water with cuprum ions is a manufactured by alternative medicine and called a bell s water,that by a reason, as on Russia her received in smelting are cuprum bells ,and also her using in systemic diseases for connective tissue.As her cooking,like a golden water,as in cup add a piece of cuprum as on size in top on ten cm, and cuprum need to be a mark M1 or not oxygen. As and other marks for cuprum and her alloys are containing harmful substances.

As this water drink on 3 gulps since on the morning before breakfast and a one individual contraindication for using this water as inborn hard disease Wilson konoval ,and other contraindications are not having as by a quantity and time of use.

via Blogger https://ift.tt/2QVyHLs

#Blogger #connective #copper #cuprum #fibrosis #golden #nerve #tissue

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urologistinnoida · 4 years

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Urethral Stricture: Causes and Treatment

Urethral stenosis is a narrowing of a segment of the urethra, which can result in a decrease or even complete interruption of the urinary flow, resulting in a series of complications, explains the best urologist in Noida. The urethra is a tubular organ through which urine flows out of the bladder. In men, the urethra is longer. In its innermost part, just at the exit of the bladder, the urethra crosses the prostate. Near the exit of the bladder is the urinary sphincter, which controls the voluntary elimination of urine (continence). Any part of the urethra can be affected, and the extent of the narrowing can vary from a few millimetres or even affect the urethra throughout its length. In general, there is deposition of scar tissue (fibrosis) in the region of the stenosis. This type of problem is more common and more complex in men, says the urologist in Noida. Causes Trauma or urethral lesions that, when healing, can determine an excessive deposition of fibrotic tissue, causing a decrease in the calibre of the urethral canal. There are several types of trauma capable of injuring the urethra: pelvic fractures, "fall to rider" (which occurs, for example, when the person has a bicycle accident and traumatizes the perineum region). Medical procedures with urethral manipulation (cystoscopy, prostate surgery, passage of urethral tubes, among others) and even radiotherapy can also produce strictures, even when done properly, says the urologist in Greater Noida. Infections such as urethritis caused by sexually transmitted diseases (gonorrhoea or chlamydia). Even with the proper treatment and cure of the infection, the healing process resulting from tissue inflammation can cause strictures. Congenital - some new-borns are already born with stenosis. Cancer is a rare cause of stenosis. The primary tumour is usually located in the prostate or bladder. Symptoms Reduced flow of urine is usually the first symptom. Voiding difficulty is quite common, but complete interruption of flow is rare. Spread or double jet. Urine drip after urination. Increased urination frequency (need to urinate more often than usual). Nycturia (waking up and getting up at night to urinate). Burning at the time of urination. Urinary incontinence in some cases. Complications When you have a urethral narrowing, the bladder muscle starts to work, making more effort to generate a urinary flow that can overcome the region of stenosis. Even so, depending on the degree of the stenosis, part of the urine may be retained inside the bladder (residual urine). This residue can result in recurrent urinary infections, prostatitis, orchitis (infection of the testicles) and pyelonephritis (infection of the kidneys). An abscess near the site of the stenosis can further aggravate the obstructive condition. Rarely, some patients with chronic inflammation due to urethral strictures can develop cancer, states the best urologist in Greater Noida. Tests for detection of urethral stenosis Urofluxometry - Evaluation of the force of the urinary stream, which is obtained when the patient urinates in a device that measures the flow of urine (ml / s). Stenoses determine decreased flow. Urethrocystography - Examination in which x-ray plates are made with the urethra filled with contrast. Thus, the location and extent of the narrowing can be determined. Cystoscopy - Examining the region of the stenosis with a special endoscope may be indicated in some cases. Treatment Urethral dilation - Type of outpatient treatment. The region of the stenosis is dilated with the use of progressive gauge plastic urethral tubes. The objective of this method is to try to supply the fibrotic tissue of the stenosis in order to increase / stabilize the internal diameter of the urethral canal. As the urethra is a tubular organ and the scar tissue tends to contract, repeated dilation sessions are generally necessary to maintain the urethral lumen. Some patients learn to self-dilate when the procedure has to be performed at very short intervals. The dilations can be used as an initial treatment in short and mild stenosis, or even in the post-surgical period to stabilize the operated segment, explains the urologist in Ghaziabad. Urethrotomy - A special type of endoscope (called a cystoscope) is introduced through the urethra to the site of the stenosis. A small blade embedded in the device cuts the fibrosis region along the stenotic segment, thereby increasing the light of the urethra. Although most patients improve their symptoms for some time, only about 30% are definitively cured with this type of procedure. Therefore, many end up having to repeat the urethromia from time to time. It is an attractive method because it is performed in a non-invasive endoscopic way. It is more suitable for relatively short strictures (less than 1.5 cm), says the best urologist in Ghaziabad. Surgery - It may be an option to the treatments mentioned above. There are several different types of techniques. For relatively short stenoses, the stenosed urethra can be removed and the urethral stumps are again joined with suture points. If the stenosis is long, skin flaps from the region (for example, a foreskin flap) can be rotated to replace the diseased foreskin segment. These procedures have a higher success rate. Urethral stents - Used in difficult and complex cases when other types of treatment have had no effect or when the patient's clinical conditions prevent major surgery. Immediate relief is usually obtained, however, over time, fibrotic tissue progressively surrounds the stent, says the urologist in Delhi. Read the full article

#health #UrethralStricture #UrologistinGreaterNoida #UrologistinNoida

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anamorales · 5 years

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Friday Faves

Hi friends! Happy Friday! Hope you’re having a lovely morning. It feels like fall here in Tucson and I am here.for.it. The mornings have a hint of coolness to them and it’s perfect weather for hiking and playing outside. I’m looking forward to a walk with P and the puppers this morning. This weekend is the Greek festival in Tucson (OPA!) and we’re heading to Phoenix to check out the new Great Wolf Lodge. I think the girls are going to love it! I’d love to hear what you have going on.

Here are some faves from the week and around the web. I always love hearing about your faves, too, so please shout out something you’re lovin’ in the comments.

Adventures from lately:

The Pilot and I attended Roundup for a Cure last weekend, which is a fundraiser for the Cystic Fibrosis Foundation. We went with a large group of friends and also had the opportunity to connect with some inspiring CF families. It was really incredible to learn about the new treatments that are being offered and I keep praying that these incredible doctors and researchers are able to develop a cure.

The theme was Greatest Showman -esque (like turn-of-the-century carnival) with acrobats, aerial silks, carnival games, people walking around on stilts, and a Tarot card reader. They also had a silent auction and the Pilot and I are notorious for having a couple glasses of wine and going bid crazy. We walked away with 6 prizes lol. It was a great date night, especially since the Pilot was only in town for a couple of days.

A voice lesson! You guys. I was blown away by all of your kind, supportive, and inspiring comments about my choir roadkill post. It was so awesome to read your thoughts and similar experiences. I always feel a bit nervous when I put myself *out there* here on the blog, but you always make me feel thankful I did it. Since I’m trying out for the choir again in a few months, I booked a voice lesson with a local coach. We did tons of warm-ups and scale work, then I got to sing some fun songs, which was a nice break after drilling my Italian aria back into my head along with the classical excepts. I sang Shallow, On My Own (cliché but I’ll always love it) and some old showtunes. It was an hour out of my day that I didn’t need to spend since I had two deadlines due the following day, but it was SO worth it.

Read, watch, listen:

This Is Us. I’ve been impatiently waiting for This Is Us to return all summer. The first episode back didn’t disappoint. No spoilers or anything, but it reminded me of the pilot episode. I was sobbing with chills all over my body, so amazed by how it all came together. It was so good I might have to rewatch it this weekend.

Definitely check out this week’s podcast episode about plastic surgery! This was one of my highest-downloaded episodes yet, and it’s a fun one.

12 book suggestions.

What we can do about climate change.

Fitness:

Don’t forget to sign up for the 7-day reset! The fun starts on Monday and I’ll have all of the info emailed over tonight. You’ll also get daily emails from me, plus access to our closed Facebook group. It’s free and the perfect way to rest healthy habits as we head into the holiday season! Just enter your email info here.

Easy ways to calm pre-race nerves.

What to eat before and after a long run.

Good eats:

The fam came over for dinner on Wednesday night and we basically had a mini Thanksgiving. Madre brought turkey, ham with pineapple, mashed potatoes, gravy, and bread. I made an enormous cheese board (as usual),

Skinnytaste turkey pumpkin chili (one of my fave fall recipes!),

and Kyle brought over the best green goddess salad from August Rhodes. Nani brought pumpkin pie.

It was an epic feast and the kiddos all ran around playing while the adults drank wine and chatted. The only thing missing was the Pilot, but it was a pretty great night.

You need these brownies in your life.

Easy pumpkin spice granola.

Still loving this chickpea scramble.

Just for kicks:

The Pilot sent this to me and I cried a little laughing.

Happy Friday! Thanks so much for stopping by the blog today. <3

Gina

The post Friday Faves appeared first on The Fitnessista.

Friday Faves published first on https://immigrationways.tumblr.com/

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juniperpublishers-jdvs · 5 years

Text

Portosystemic Encephalopathy in a Dog- Juniper Publishers

Abstract

Portosystemic shunt is an abnormal vascular connection between the portal and systemic venous system. Due to this abnormal network of vessels, portal venous blood and its toxic by-products by-pass the liver and directly mix into the systemic circulation. It is a well-known congenital cause of encephalopathy which is characterized by high ammonium levels. Our case; a two-year-old male dog was brought to our clinic with tonic-clonic epileptic seizures and allotriophagia presenting for the last four months.Diagnosis of portosystemic shunt was made, and a surgical operation was planned. After the operation, ammonium levels decreased sharply. However, ammonium levels have started to rise again the month following the procedure and leaded to more severe symptoms. Consequently, the patient was euthanized after three months.

Keywords: Portosystemic shunt; Encephalopathy; Hepatic encephalopathy

Introduction

Portosystemic shunt is an abnormal venous connection between the portal system and systemic circulation; this alternative route causes by-passing of blood and its toxic metabolites through the liver and directly drain into the systemic venous circulation. Many different types of congenital port vascular anomalies have been reported in dogs [1]. The incidence of congenital portosystemic shunt has been reported as 0.18% of in dogs[2]. Extrahepatic portosystemic shunts are usually seen in small-breed dogs. Affected dogs generally show symptoms before the age of two, but some patients do not develop clinical symptoms until they are older[3]. The most common symptoms are anxiety, lethargy and apathy while intrahepatic portosystemic shunts and cirrhosis cause hepatic encephalopathy more commonly[4,5]. Ultrasonography, magnetic resonance imaging and/or computed tomography were used for definitive diagnosis [6].

Case History

Two-year-old, male, mix-breed dog presented with an epileptic seizures and suspicion of foreign body ingestion. Anamnesis revealed that he had abnormal activities such as allotriophagia and increased aggression for the last four months. Body temperature, respiratory and pulse rate were in the normal range but there was abdominal discomfort during palpation. While the CBC’s results were within normal ranges, serum ALT, AST and ALP levels were doubled. The serum ammonium level (SAL) was high (376 mmol/L).Urinalysis revealed proteinuria (2+) and bilirubinuria (2+), significant amount of ammonium biurate crystals were present in the urinary sediment. CT revealed multiple foreign bodies in the stomach stones in the bladder and both kidneys (Figure1). Generalized epileptiform waves were observed in electroencephalography (Figure 2).According to our findings, diagnosis of portosystemic shunt was made, and an operation was planned in order to correct it surgically.

Supporting therapy was begun immediately after the operation. Lactulose (5mls per 2.5 lbs. qid) was used for binding the ammonia present in the intestines. Phenobarbital (2mg/kg Bid) was given to inhibit the tonic-clonic epileptic seizures. After the operation SAL was decreased rapidly to 122 mmol/L. But the patient died three months after the operation. During the post mortem examination; stones of 4 mm diameter were detected in the kidneys and in the urinary bladder. There was also micro hepatica, portal fibrosis, thyroid gland degeneration and chronic interstitial nephritis.

Discussion

Porto-systemic encephalopathy is a reversible, complex neuropsychiatric syndrome characterized by disturbances in consciousness and behavior, personality changes and fluctuating neurological signs and distinctive electroencephalographic changes, which occur secondary to chronic liver disease[7,8]. Operative ligation of portosystemic shunts is effective in controlling chronic portosystemic encephalopathy, but also holds a high mortality rate[9,10]. In our patient presenting with high SAL and tonic-clonic seizures, we suspected presence of a portosystemic shunt. Surgery revealed an extrahepatic portosystemic shunt and it was corrected. However, the results were not satisfying; ammonium levels have started to rise again a month after the procedure and even leaded to more severe symptoms. We believe that there was also intrahepatic microvascular dysplasia. Quality of life was deteriorated day-byday and patient was euthanized in accordance with the request by care-givers three months after the surgery.

Conclusion

Surgical correction of the portosystemic shunt may provide a cure for extra-hepatic portosystemic shunt induced encephalopathy, but success of treatment is low in the presence of portal vein hypoplasia, microvascular intrahepatic shunt or cirrhosis.

To know more about journal of veterinary science impact factor: https://juniperpublishers.com/jdvs/index.php

To know more about Open Access Publishers: Juniper Publishers

#Juniper Publishers #Juniper Publishers Group #Veterinary Sciences #parasitology

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grim-grinning-gorgeous · 7 years

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Well after 35 years of struggling with Cystic Fibrosis, my brother is going into hospice next week. I am not handling it well. We are all looking forward to the day he no longer suffers, but confronting the reality of his disease reaching its final conclusion is harder than we thought. This is the second time my mother will have lost a child to this illness, and I don't know how she has kept going this long. I can’t wrap my head around losing the only sibling I’ve had a chance to know, and even though I HATE CF for what it has done to him and to us as a family, I can’t picture it not being part of my reality. It’s been there in the background for all my 25 years. It amazes me that this condition that destroys so many lives and families is still glossed over for other things. Don’t get me wrong, cancer is horrible, I have lost loved ones to that too. But CF is there from the day you are born. And when you grow up with it, you grow up knowing that your disease will eventually kill you, maybe even before your life begins. It might rob you of the chance to have children. It definitely robs you of the ability to breathe. And there is no cure, but there is also no “remission”. It is there until you aren’t. So you and those who love you just get to wait, thankful for meds that give you good days, but always aware that the bad days will return at some point.

So, like so many others, I am begging for awareness for this issue. So we can get closer to a day when CF is not a death sentence. So we can get closer to less hospital stays and surgeries. And so we can get closer to the loved ones of CF victims not always having to explain what the disease is because most people just don’t know.

#cystic fibrosis #cf #cf awareness

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erectiledysfunc · 4 years

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phawareglobal · 4 years

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Kaarina Wilson - phaware® interview 321

COVID-19 SPECIAL EDITION: Kaarina Wilson is a self-described Canadian patient, leader, chronic illness defeater from Canada. She discusses her PH, CTEPH, and scleroderma diagnosis as well as the road to lung transplant, rehab, recovery and self-isolation in a time of coronavirus.

This episode was recorded from her Toronto hospital bed on 4/2/20. Kaarina lost her rare disease battle 3 days later. #phaware #COVID19

My name is Kaarina Wilson. I'm in Toronto, Ontario, at the Toronto General Hospital. My connection is that I am a patient with pulmonary arterial hypertension, CTEPH, and heart failure-related-pulmonary hypertension.

So I first knew something was really wrong in November of 2017. I was on vacation. I really couldn't handle the hills or even walking on flat land anymore. So I started the process of getting diagnosed after I came home. I was finally diagnosed in October of 2018. By March of 2019, I was on oxygen and in May I had PTE surgery, which is pulmonary thromboembolic surgery. Unfortunately, mine was a complicated case and I got worse really quickly after that.

I was in the hospital for a good couple months after that and I had some complications. I had some numbness after surgery in my feet, which was a forbearer of things to come. I had been bedridden for a while before surgery and I really don't believe that I would have survived much longer if I hadn't had that surgery at the time. I was diagnosed in October of 2018 with CTEPH, which was my first diagnosis. Then my transplant happened in October of 2019. So in that time, after PTE surgery, my pulmonary pressure got worse fairly quickly. Then I'm learned that my pulmonary hypertension was not cured and that I actually had a bunch of different types, and that things were getting worse fairly quickly, because I was already in heart failure. After PD surgery, I went home and that was actually a really good time. I felt grateful all the time. I hung out with my mom. We had fruit salad every day and walked around in the sunshine with my walker, which I nicknamed Betsy. But then it sort of fell off a cliff. Not literally, of course, but it felt like one day I just woke up and things were a million times worse. It turned out that I had had mild heart attack. So things got bad really quickly. I've been in hospital since August 15th of 2019. The original reason was that I developed Guillain-Barré syndrome. It's an autoimmune disease that attacks the myelin. It basically demyelinates fairly quickly, like within hours. Then your nerves grow back, but it takes a really long time. So I haven't been able to walk. It from the waist down and now it's just from the knees down. So it is coming back. It's just very slow. So I'm doing physio every day and I alternate between rehab and in the hospital depending on what's going on with my lungs. After surgery I developed pulmonary fibrosis in my lungs and I've had pneumonia many times now, which led to the pulmonary fibrosis, as well as the fact that I have scleroderma. I've had to deal with it like one day at a time. Sometimes even just like one breath at a time. I made myself some catch phrases, like “one breath, one moment.” Sometimes even just “this too shall pass” gets me through to the next moment. What drives me is I have a niece, she's six years old and I want to be there to see her grow up. I want to spend as much time with my family as I can. My sister and my parents and all my friends. I have a great group of friends that are so supportive and so nonjudgmental. I have so many blessings in my life. That's what drives me. These days with the coronavirus and what's been going on globally, it's really affected me, because I'm not allowed to have visitors anymore. My mom used to come visit me every day. It's changed the way that I communicate with people. It seems people are more receptive to communicating now in ways that are alternative to face to face. It used to be that if you couldn't visit then we really wouldn't speak, but now it's like, oh, we can FaceTime or talk in another online platform, or even just, there's so many different ways to communicate these days that it's good to take advantage of them. It's different than it was. There's less people, there's less supplies. It's really sort of bare bones right now, because we're just waiting and want to be prepared. It is an eerie world right now. Just like outside in the streets where there's nobody, there's nobody in the hospitals either. So to everybody who’s recently diagnosed out there, I just have to say, keep the faith. Believe that the most positive outcome is going to happen. If you must, prepare for the worst. It's not a bad idea to go into it prepared. I mean that both with powers of attorney and equipped with a plan. But just believe that it's going to end up in your favor and chances are that with that it will. More times than not, it will. Just roll with the punches, because it won't always, and you got to be able to move on from negative news and from negativity in general. Just keep positive. It's the hardest thing in the world. Sometimes when people have told me to be positive, I wanted to just scream at them, but it's the best thing for you. I truly believe that. I don't think I would've lasted three days without transplant. I was on life support and luckily I ended up getting listed and getting transplanted two days later. Oh, I was definitely apprehensive about it. Before I had a lot of time to think about the outcomes that could happen and I was, hemming and hawing, unsure if that was really the road I wanted to go down, because I know that it becomes the disease unto itself. You have to take a bunch of medication for the rest of your life and you're immunosuppressed all the time. It's hard. I wasn't sure, but when the time came, oh, you better believe I wanted it. I desperately, desperately wanted it and it happened and I'm so grateful. My name is Kaarina Wilson and I'm aware that I'm rare.

Stay up to date with the latest on Coronavirus Disease 2019 at the CDC Website.

Click here for Important COVID-19 Information & Resources for PAH Patients & Caregivers from the phaware website.

Listen and View more on the official phaware™ podcast site

#pulmonary hypertension #phaware #rare disease #lung disease #clinical trials #podcast #PH #asthma

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jonasmaurer · 5 years

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Friday Faves

Here are some faves from the week and around the web. I always love hearing about your faves, too, so please shout out something you’re lovin’ in the comments.

Adventures from lately:

Read, watch, listen:

Definitely check out this week’s podcast episode about plastic surgery! This was one of my highest-downloaded episodes yet, and it’s a fun one.

12 book suggestions.

What we can do about climate change.

Fitness:

Easy ways to calm pre-race nerves.

What to eat before and after a long run.

Good eats:

Skinnytaste turkey pumpkin chili (one of my fave fall recipes!),

and Kyle brought over the best green goddess salad from August Rhodes. Nani brought pumpkin pie.

It was an epic feast and the kiddos all ran around playing while the adults drank wine and chatted. The only thing missing was the Pilot, but it was a pretty great night.

You need these brownies in your life.

Easy pumpkin spice granola.

Still loving this chickpea scramble.

Just for kicks:

The Pilot sent this to me and I cried a little laughing.

Happy Friday! Thanks so much for stopping by the blog today. <3

Gina

The post Friday Faves appeared first on The Fitnessista.

Friday Faves published first on https://olimpsportnutritionde.tumblr.com/

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surgery-tours-india-blog · 6 years

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Organ Transplant in India | Best Organ Transplant Hospital & Treatment Centre in India | SurgeryToursIndia.com

Organ Transplant in India

Most often this is the only option when a particular organ has reached end-state organ failure. Organ transplantation surgery in India is high-standard in technical expertise & normally involve heart, kidneys, lungs, liver, pancreas, thymus & intestine. Tissues which are also selectively transplanted include musculoskeletal grafts like bones & tendons, heart valves, cornea, skin, veins, & nerves. By far heart transplant & kidney transplantation are the most frequent organ transplants carried out globally. Accepted as the best treatment for end stage organ failures, organ procurement for all types of transplantation procedures can, however, be cumbersome.

What is Organ Transplantation?

Replacement of a failing organ with another persons’ healthy organ is generally stated as Organ Transplant. Organs which are mostly transplanted include Heart, Kidney, Lung, Liver, Pancreas, Small Intestine & the list goes on. Multiple organs can be transplanted at a time, for instance, lung & heart can be transplanted in a single surgery.

Organ Transplantation Surgery in India with SurgeryToursIndia.com

Organ procurement process involves timely removal from donors along with attached legal requirements including consent & definition of death. Kidney transplantation treatments in India are subject to legal issues which require being effectively sorted out. Procurement often requires ensuring rigorous selection procedures. In treatments where possible, living donors with good health are simpler & carry negligible risks. This situation allows periodical follow-up of donor ensuring optimal management without any untoward consequences.

Cost of Organ Transplantation in India

Many international patients prefer India for Organ transplantation just because of low cost of treatment & top-class medical facilities when compared to other countries. Low Kidney Transplantation Cost in India allows people from all strata of society get best medical services.

Common Organ Transplants

1. Kidney Transplant

Kidney Transplantation is also known as Renal Transplantation. This organ transplant of kidney into a patient with end-stage renal failure is typically classified as living-donor or deceased-donor transplantation depending upon the source of donor organ. Regardless of primary cause indication for kidney transplant is an end-stage renal failure. Common diseases leading to this medical condition include diabetes mellitus, focal segmental glomerulosclerosis, infections & malignant hypertension. Genetic factors indicating kidney transplant include polycystic kidney disease, variety of inborn errors of metabolism & autoimmune medical conditions like lupus. The majority of prospective recipients for renal transplant are on dialysis & expecting transplantation as viable medical solution.

2. Liver Transplant

Liver Transplantation is also known as Hepatic Transplantation. It involves replacing a diseased liver with a healthy one from another person. Orthotropic Transplantation is the most common technique used for Liver Transplant where the native liver is replaced by donor organ in the same anatomic location. Liver Transplant is one of the most viable treatment options for acute liver failure in end-stage liver disease.

This surgical procedure is quite demanding on medical professionals & operating time range between 4-18 hours depending upon outcome. Numerous sutures & an astomoses, reconnections & disconnections are required to be made for Liver Transplants to succeed. This surgical procedure also requires an eligible recipient with a well-calibrated cadaveric donor match. Potentially available to acute or chronic conditions resulting from irreversible liver dysfunction, advanced age & serious heart, pulmonary or other diseases may prevent transplantation.

3.Bone marrow transplant

Bone marrow transplantation, also known as stem cell transplant is the surgical procedure in which the damaged bone marrow is replaced with the healthy bone marrow cells. It is done to treat diseases like leukaemia, aplastic anaemia, lymphomas as Hodgkin's disease, multiple myeloma, immune deficiency disorders etc.

4. Heart Transplant

Heart Transplant is also known as Cardiac Transplant. This surgical transplantation procedure is normally performed on patients with severe coronary artery disease or end-stage heart failure. A common procedure involves extracting a working heart from recently diseased organ donor & implanting this into the patient. Patients own heart is either removed or sometimes left in place as support to donor heart. Though it is no cure for heart disease but life-saving treatment, post-operational survival period records average 15 years.

5. Lung Transplant

Lung Transplantation is also known as Pulmonary Transplantation. It is a surgical procedure where patient’s diseased lungs are partially or totally replaced by donor’s lungs. Donor’s lungs are retrieved from living or deceased donors. In the case of a living donor, it is only possible to receive just one lung lobe which is sufficient in some lung disease conditions. However, with other lung diseases like cystic fibrosis, it is imperative that recipients obtain two lungs. Though Lung Transplants come with certain associated risks, they at the same time also enhance quality of life & extend expectancy for patients with end-stage pulmonary diseases.

6. Pancreas Transplant

Pancreas Transplant involves implanting healthy pancreas that can produce insulin, into a person who is suffering from diabetes. The pancreas is a vital organ assisting digestion. Without disturbing the patient’s native pancreas, the new donor pancreas is attached at a different location. The idea is to survive on under-functional native pancreas in the event of rejection of donor pancreas. New, healthy pancreas, generally come from donors who have recently died. Presently, Pancreas Transplants are performed for patients with insulin-dependent diabetes. General complications associated with Pancreas Transplant surgery include bleeding, infection, pancreatitis, thrombosis & rejection which may immediately occur or at any time in future life.

7. Intestine Transplant

Intestine Transplantation is also known as Intestinal Transplantation or Small Bowel Transplantation. This is a surgical replacement procedure of small intestine for acute & chronic cases of intestinal failure. Though cases of intestinal failure can often successfully be treated with alternative therapies, associated complications like liver disease & short bowel syndrome make Intestine Transplant appear as the only viable option. Intestine Transplant is a rare type of organ transplantation surgical procedure but which is increasingly becoming prevalent as a therapeutic option due to surgical advances, immunosuppressive regimens & clinical management.

Good Candidates for Organ Transplant

Not everyone is an ideal candidate for organ Transplant. You will have to undergo tests at the transplant center & qualify. You will not be a good candidate in case you have infections, heart disease beyond control, alcohol or drug problems, or any other serious health care issue. Then perhaps, if you are selected, will be put on a waitlist. The essential things that are checked before organ transplantation are:

Condition of Patient

Condition of Donor

Organ Condition

Compatibility between Donor & Receiver

SurgeryToursIndia.com Cares

At SurgeryToursIndia.com we recognize the significance of excellent health and well-being of our guests and hence our objective is to provide organ transplant in India at affordable prices. A preferred association with best hospitals and top surgeons helps us advise the best treatment plan for you at most affordable cost.

We encourage you to educate yourself about organ transplantstion laws in India, benefits from the right kind of procedure and then make an informed decision.

SurgeryToursIndia.com thus invites you for a free consultation with top surgeons and assures you hassle free arrangements for examinations, procedures, recovery, travel and stay in India.

You can be rest assured that with SurgeryToursIndia.com expertise, we bring in a wonderful experience of medical tourism, which we have been doing so for almost a decade now.

Medical history and diagnostic reports may be sent to [email protected] for an early response from the case managers.

For more information, medical assessment and medical quote send your detailed medical history and medical reports, as email attachment to:

Email:- [email protected]

WhatsApp or Call: +91-8882921234 | +91- 9730001540

Visit:- http://www.surgerytoursindia.com/transplant-surgery/

Tags: Organ Transplantation India, Kidney Transplant, Bone Marrow Transplant, Multi Organ Transplant, lung transplant in india, heart transplant in india, pancreas transplant in india, intestine transplant in india, Organ Transplantation cost in India, Best Organ Transplant Hospital & Treatment Centre in India, organ transplant India, best organ transplant hospital in India, cost of organ transplant in India

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thismountainhastigers · 7 years

Text

Writing Assignment #3

Designer Jeans to Designer Genes

Jurassic Park (Spielberg 1993) is often lauded as one of the greatest films of the last fifty years. Culturally, it contributed to the widespread use of computer-generated special effects, spurring even more famous film series like the Star Wars prequels and, later on, Lord of the Rings. It also gifted us the succinct, no-nonsense line from Jeff Goldblum’s character, Dr. Ian Malcolm, regarding the dangers of introducing new technology without thinking about its possible consequences: “Your scientists were so preoccupied with whether they could, they didn't stop to think if they should.” Given the explosion of the field of biotechnology in the twenty years following Jurassic Park’s release, it is rather fitting that Dr. Malcolm was referring to the reckless use of genetic manipulation to create a world that, in the end, was beyond mankind’s control. However, no matter how tempting it may be to approach the topic of genetic engineering as only capable of producing real-life scenes from Jurassic Park, Brave New World, or Gattaca, technology of any kind can only help (or hurt) us as much as we let it. If we understand our limits (and set them if need be), we can determine how such genetic intervention will effect us as individuals and as a society as a whole and to what extent we should allow it.

Our main limit right now is our knowledge. We still have much to learn about all of the intricacies of our genetic code. Beyond all the happenings at the molecular level, the most important factors involved in gene editing may be linked genes, where the phenotype of one characteristic is tied to the phenotype of another. If we dive too quickly into changing genes that have unknown relationships with others, we would easily end up doing more harm than good. Even some genetic diseases (most famously sickle cell anemia and cystic fibrosis) are shown to create the phenomenon known as heterozygote advantage, where simply carrying one copy of the recessive gene for the genetic disease confers some benefits to the individual in resisting another bacterial or viral disease (in this case, malaria and possibly cholera, typhoid, and tuberculosis) (Gabriel et al. 1994). By fixing one problem at the genetic level, we could open ourselves up to unanticipated dangers.

Beyond our limits regarding our own biology, we still do not know everything about CRISPR-Cas9 (the technology that would allow us to edit specific sites in the genome), and what we do know points to the fact that it is not perfect; the process itself has its own limitations. Of the ways that a double-stranded break in the DNA can be repaired (the way that CRISPR-Cas9 removes a “faulty” sequence), the most common pathway utilized by CRISPR-Cas9 is non- homologous end-joining—which happens to be the most error-prone compared to other options, such as homology directed repair (Lieber 2008). While it can correct mutations, the process is unreliable at best when used to correct mutations in individuals compared to groups of test subjects (Le Page 2017). However, at the rate that research is currently progressing, let’s assume for a moment that we will reach the point of using CRISPR-Cas9 as a common medical technique by the end of the century, and that we will anticipate and fix all potential problems at the biological level. In essence, we will have removed all practical limits to the widespread use of genetic engineering and must turn our attention to ethical and moral self-imposed limits.

It is in medicine where we will reap the first benefits of being able to alter our genetic code, though calling CRISPR-Cas9 the “cure” for genetic diseases is slightly inaccurate, if we take the definition of “cure” to be a treatment that restores a patient to full health. Its use as something to stop the problem of a genetic disease before it truly becomes a problem more closely mirrors a vaccine—something done in advance to prevent the disease from manifesting itself in the body. And who among us would deny a child the polio or measles vaccine?* In the same way, if it was possible to prevent Huntington’s disease or some other genetic defect, how could we justify our lack of effort to alleviate suffering that, in light of new technology, is completely unnecessary?

Recently, the idea that a life characterized by suffering is not a life worth living has become more popular among debates surrounding euthanasia and abortion. In these cases, some would decide that life is no longer worth anything after being diagnosed with a terminal or otherwise painful illness (physical or, in some cases, mental) or learning that a fetus possesses some disability or disease that would make life too difficult either for the child or the family. While euthanasia and assisted suicide are less popular on a global scale, we already see women largely opting for abortion upon realizing their potential child would live with a life-altering illness. The most famous example is Iceland, where it was recently revealed that nearly 100% of women choose abortion after learning that their child has trisomy 21, which results in Down’s syndrome (Lajka 2017). Wanting to avoid suffering and struggle is not inherently a bad thing; if nothing else, wanting an easier way to do things has brought about much of technology as we know it today. People will almost always go for the option that does not add any more difficulty to their lives. If we had to choose between a society that performed selective abortion on those with less-than-ideal characteristics and one that could both genetically identify and fix the problem before it is too late, I would embrace the latter with little reservation. A technologically modified life is better than no life at all.

Currently, our society in general seems to hold to the idea that an ideal human is simply a healthy one—for now. Using CRISPR-Cas9 as a medical treatment in people seems like the obvious path to take if it could eliminate the risk of developing certain diseases from humanity’s gene pool, but what happens when our idea of the ideal human changes? How can we use it to our advantage then? When there are no more problems for medicine to fix, medicine becomes about elevating the human race beyond its current constructs. The immediate upgrades that come to mind are all physical: being stronger or faster, having better immune systems or higher pain tolerance, even something as superficial as making people more attractive. However, as our knowledge of neurobiology grows, could we theoretically design a person right down to their personality? We have some evidence that the physical brain structure influences a person’s personality (DeYoung et al. 2011), so if we found a gene that encodes a particular region of the brain that results in people who are rash and quick to anger, are we not bound to remove from society a population that could threaten social stability? Here I believe we are getting dangerously close to impeding on the rights of an individual, as we spell out their life before they take their first breath. (Likely before they move past a unicellular stage.) If we set no limits on what we can edit in a person, we may end up sacrificing free will for the sake of implementing peaceful society.

If we take CRISPR-Cas9 to its full potential, we will have eliminated all genetic diseases by removing them from the gene pool or fixing mutations when they occur. Perhaps we will even eliminate susceptibility to cancer or other age-related diseases. We might not conquer death in the sense of bringing people back to life, but we will certainly be able to put it off for a considerably longer period of time (Blagosklonny 2012). A group of such “ideal” people, not only in body but also in mind, would theoretically form a perfect society if we can remove the selfish and the rash by simply not allowing them to exist in the first place. We would be eliminating metaphorical “diseases” like violence and political corruption. However, amidst all the optimistic ideas about what we can do, we have to consider what we actually will do. Technology is not cheap, it is always first introduced among the wealthy before becoming more common in the lower levels of society (Harari 2016). That is not to say that if it cannot immediately be available to all then it should not be available to any—we do not keep people from a life-saving heart surgery if there is someone with the same problem that cannot afford it. However, if we do not take the necessary steps to prevent abuses of this technology, we could end up with society governed by a physically perfect elite, capable of designing their own lower, subservient classes (if such classes are allowed access to the technology at all). In what would be the worst abuse of power, they could, with enough time, simply generate a lower class that is content in their subjugation. In essence, the “haves” could reduce the “have-nots” to organic robots.

Beyond the potential loss of free will (I will admit that it is a bit of stretch even for a dystopian society), my biggest fear within the realm of genetic engineering applies to how we as a society view life. Does life just become something to be bought, sold, and processed when too many people get involved in the business of creating it? When we think of things being “designed,” the first thing to come to mind is often clothing: something with a particular label on it that we buy (occasionally to showcase our own wealth or status) and eventually throw out in favor of the “next big thing.” Life, more specifically that of a human individual, should not be something we ever come to see as able to be replaced at the earliest convenience or is only worth anything so long as it serves a purpose. This brings us back to the potential new direction of the field of medicine: treating the natural development of life as a problem to be fixed (such as baldness, wrinkles, and other symptoms of aging) and not something we should count ourselves as fortunate to possess as a sign that we have made it this far.

I do believe in life after death, therefore I see no reason to live forever if forever exists on the other side. At the same time, I believe life (in this life) is rare, and therefore has value in that rarity. Going by the current evidence, we are the only ones with it in the universe. Regardless of whether or not we share it with others, the sheer length of time that it took us to get this far (from organic compounds to rational thought) is awe-inspiring at the very least. What’s more, it only happened here once, four billion years ago with the last universal common ancestor. Life should be treated as a gift, and one that we ought not to withhold from someone. Technology alone with the power to alter life as we know it is not inherently good or evil; it is what we choose to do with it that determines its moral status in society. By all means, we should use the genetic engineering to create a healthier society. However, lines will have to be drawn around editing the parts of ourselves that make us essentially human, namely our ability to rationalize and make decisions for ourselves with little outside influence. As far as “upgrades” go, I would caution people to consider what things are truly problems that need to be fixed and what things would change us in only a superficial way, or those changes which, when made in haste, transform us negatively in the end. To quote Dr. Malcolm one more time, “genetic power is the most awesome force the planet's ever seen,” so let’s not “wield it like a kid that's found his dad's gun.”

*Admittedly, a not-insignificant number of people (Blake 2015), but work with me here.

References

Blagosklonny, Mikhail V. "Answering the Ultimate Question, “What Is the Proximal Cause of Aging?”." Aging 4.12 (2012): 861-77. Print. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615154/

Blake, Aaron. “Here's How Many Americans Are Actually Anti-Vaxxers.” The Washington Post, WP Company, 9 Feb. 2015, www.washingtonpost.com/news/the- fix/wp/2015/02/09/heres-how-many-americans-are-actually-anti- vaxxers/?utm_term=.fecac274739b.

DeYoung, C.G., et al. "Testing Predictions from Personality Neuroscience: Brain Structure and the Big Five." Psychological Science 21.6 (2011): 820-28. Print. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049165/

Harari, Yuval N. Homo Deus: A Brief History of Tomorrow. Harvill Secker, 2016. Print.

Gabriel, S.E., et al. "Cystic Fibrosis Heterozygote Resistance to Cholera Toxin in the Cystic Fibrosis Mouse Model." Science 266.5182 (1994): 107-09. Print. http://science.sciencemag.org/content/266/5182/107

Lajka, Julian Quinones Arijeta. “‘What Kind of Society Do You Want to Live in?": Inside the Country Where Down Syndrome Is Disappearing.” CBS News, CBS Interactive, 14 Aug. 2017, www.cbsnews.com/news/down-syndrome-iceland/.

Le Page, Michael. “We Still Don't Really Know What CRISPR Does to Human Embryos.” New Scientist, 1 Sept. 2017, www.newscientist.com/article/2146061-we-still-dont-really-know- what-crispr-does-to-human-embryos/.

Lieber, M.R. "The Mechanism of Human Nonhomologous DNA End Joining." Journal of Biological Chemistry 283.1 (2008): 1-5. Print. https://www.ncbi.nlm.nih.gov/pubmed/17999957

Spielberg, Steven. Jurassic Park. Universal Pictures. 1993. Film. https://en.oxforddictionaries.com/definition/cure

#definitely felt better about this one than the last one #writing assignment

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msendowarrior · 7 years

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Endometriosis, what is it? What causes it? What are my treatment options?

*Disclaimer; research and information in the medical community is constantly changing and this information could change at any time. All of the information in this article will be cited at the bottom.

What is Endometriosis? Endometriosis is a disease where tissue similar (I will explain why this is so important in a moment) to the lining of the uterus grows outside of the uterus in other areas of the body. Endometriosis causes pelvic pain, heavy bleeding, and in some cases infertility. Endometriosis can remain active even during ovarian suppression and is believed by some specialists to actually produce it’s own estrogen.

So where does Endometriosis come from? No one truly knows, but there are theories.

This is why it is important that Endometriosis is classified as similar to the lining of the uterus and not the actual lining of the uterus. See, that would support Sampson’s theory of Endometriosis, also known as the Retrograde menstruation theory. If you aren’t familiar with that theory it states that “Endometriosis occurs through a process of endometrial tissue flowing back through the fallopian tubes during menstruation, entering the pelvic cavity and implanting and invading the surfaces of the pelvic structures.” This, however, has proven to be false as now they have found endometriosis in fetuses which would suggest that endo implants much earlier than menstruation even starts. This theory would also suggest that stopping someone’s period would not only stop the growth of Endometriosis but that a hysterectomy would cure them; which is an incorrect conclusion. Here’s a quote from Dr.Cook (an endometriosis specialist) “Retrograde menstruation, however, is a common phenomenon that occurs in 90% of women yet only 10% of women develop endometriosis and the refluxed material only contains minimal deposits of endometrial tissue. Furthermore, endometriosis consists of tissue that is similar but not identical to the native endometrium that lines the uterus.”

There have been a few studies done by Endometriosis specialists to find out what the cause is. So far it has been found that it could possibly be a genetic disease. There was also a theory that Endometriosis is an autoimmune disease which has now been disproven as well. You can read more about the theories of where Endometriosis comes from on Dr.cooks website and Dr. Sinervo's (Center For Endometriosis Care) website that I have a link to at the bottom.

Well then, what can we do to treat Endometriosis? As far as treatment goes there is no cure for Endometriosis. Due to the uneducation that health care professionals are supplied in medical school it is also completely mistreated and misdiagnosed. Currently the only treatments offered for Endometriosis are laparoscopic excision surgery, laparoscopic ablation surgery, birth control, depo lupron, and a new treatment Letrozole (also known as Femera), and two new drug compounds chloroindazole (CLI) and oxabicycloheptene sulfonate (OBHS) combined. Now let me discuss these treatments with you and why laparoscopic excision of Endometriosis with a specialist is currently the gold standard for treatment of Endometriosis.

Doctors are taught in medical school to treat endometriosis patients as follows; Birth control/lupron Depot, laparoscopic ablation surgery,and Hysterectomy. Now, why is this so harmful? They’re trying to treat us right?As a matter of fact, due to misinformation they are actually making things much harder on us (the patients). Here’s why

First we’ll discuss birth control. Birth control is the first line of defense doctors go to because many doctors believe that endo only happens on our period so stopping our period will stop the pain right? Wrong. Although it can help with some of the pain and symptoms associated with Endometriosis it is not a cure and does not always help especially if your pain is year round. They also believe that birth control will actually stop the growth of your Endometriosis and potentially cure you, which has been proven wrong. Endometriosis is believed to feed off of estrogen. So, if we stop estrogen production by using birth control, it will stop growing right? Again, wrong; Endometriosis is believed to produce it’s own estrogen and no matter what, you will always have excess estrogen in the body. Now, I’m not saying to stay off of birth control. It can help with some symptoms, but it will not cure you and most likely won't take away all your pain.

Let’s discuss Depot Lupron. So, how is this different from any other birth control? Lupron is a GnRH agonist. It was originally used to stunt puberty in children that had precocious puberty. Then was misused by many doctors who gave it to children to delay puberty in order to let them grow taller. After that it was used as chemo drug to treat prostate cancer. Ultimately these patients suffered with severe complications later in life such as Osteopenia, Osteoporosis, bone thinning, and side effects similar to chemo drugs. Here’s why doctors believe it can help Endometriosis. Lupron can shrink the Endometriosis and cause a patient not to have symptoms for years of their lives BUT it does not diminish the endo and it can cause severe complications in the body. I was told safely (and legally at the time) you could only be on it up to a year in your life because it is so toxic to the body. It causes bone density loss, hair loss, lowers your immune system, and can actually rot your teeth (just like any chemo drug). Dr.cook wrote on his website “There are, however, several significant problems with the use of GnRH agonists for endometriosis treatment. First, it may not work. Endometriosis can produce its own estrogen and in these cases Lupron will not suppress the endometriosis activity or pain. In more advanced cases of endometriosis, even if the Lupron suppresses the endometrial implant activity, it does nothing for the pain caused by scarring and fibrosis resulting from the invasive endometriosis.” One other huge issue with Lupron is that since it does shrink Endometriosis lesions when your surgeon goes in to remove it, it is harder to see and therefore harder to remove. Again, if you do your research and find that is the best option for you then do what you feel is right for your body. (there is more information on Lupron in the link down below)

Now, we have Letrozole (Femera). Letrozole was originally a chemo drug to treat breast cancer. Currently there is not much information on this drug, but it is very similar to Lupron.

For the last two drugs we have the drug compounds chloroindazole (CLI) and oxabicycloheptene sulfonate (OBHS). Now I can not find much information on these drugs and the study on them had the definition and theory of endometriosis wrong, but here are my findings. As far as chloroindazole goes I can find little to nothing on it but the actual chemical makeup of the drug and where to buy it. With Oxabicycloheptene still almost nothing. I did find an article that states this though “These findings suggest that OBHS provide protection directed at enhancing glial cell survival through the activation of GPER1, which, in turn, offers a novel insight into the molecular mechanisms behind the potential application of OBHS in treating Alzheimer’s disease (AD).” which is posted below. In turn when you look them up separately there isn’t much information on them. Now when you look them up together a study comes up that states this “(a professor) tested the new compounds – chloroindazole (CLI) and oxabicycloheptene sulfonate (OBHS) – in mice with endometriosis and in human endometriotic cells. Both compounds block estrogen receptors – signaling proteins that regulate a range of genes, including some that affect immune response and promote inflammation.” and they claim “When they tested them on mice, the researchers found each drug reduced the amount of endometriotic tissue or prevented its growth outside the uterus. Each drug also reduced inflammation and stopped the growth of new neurons and blood vessels that support the misplaced womb tissue..” Which, is obviously incorrect since endometriosis is not from the uterus. I don’t personally trust this study, so hopefully more research can be done on these drug compounds in the future.

So, now that we’ve discussed drugs let’s discuss surgery. After your doctors are unable to control your pain with drugs, regular gynecologists will usually suggest a laparoscopic ablation surgery. What this means is that they will go in and remove the Endometriosis by burning it off. The reason this is not considered an effective treatment is because they are only burning the top layer of the Endometriosis off, leaving disease behind to grow into the tissue. Essentially it’s a tip of the iceberg situation. You don’t know what’s going on underneath. So why would they do this and leave you with disease still in your body? Well, in medical school they are taught that to remove an endometriosis lesion it’s just as easy as that, burning it. Which has been proven ineffective after countless women have had to return for several surgeries with a very high recurrence of Endometriosis lesions as well as scar tissue.

Now if your surgeon has “done everything they can” their next step is usually hysterectomy. Bare with me on this but it is believed.. That a hysterectomy… Is also a cure! Can you believe it? See this is also taught in medical school. If you remove the uterus the endo can’t possibly come out through the fallopian tubes and implant (Sampson’s theory) . And if you get rid of the ovaries no estrogen means no Endo right? I really hope you’re detecting my sarcasm.

I’ve discouraged you all so much it’s time to bring your spirits up and talk about the last treatment for Endometriosis. No regular gynecologist or uneducated doctor will suggest this. Laparoscopic excision of Endometriosis. This is where you excise (cut) the Endometriosis out and remove it from the body. Currently this is the gold standard treatment for Endometriosis. Why is that? When a trained specialist removes endo they are looking at the bigger picture. They are looking for different color variations of endo, the depth of the lesions, where the lesions are located (which is not just limited to the pelvic cavity). So they can go in and properly cut out all of the disease. The recurrence rate of endometriosis is only 10-15% in most cases if done by a trained specialist such as Dr. Cook or Dr. Sinervo. Again, this is not a cure but it is a treatment that has the most success so far.

I hope you all found this informative and helpful.

Thank you,

Francesca Romano

***EDIT*** 10/15/2017 Updated information on endometriosis provided by Dr. John F Delumba Endometriosis specialist “Finally, another doctor (Dr Vidali) is going to start checking endometriosis specimens for estrogen and progesterone receptors. I have been urging other doctors to do this, and they will be amazed at the results. I have been doing this for 13 years. In the more advanced disease, and older patients, both receptors are usually positive (I have found 75% are positive for both estrogen and progesterone receptors. You need a receptor to stimulate the function of a cell). In the younger patients, and less advanced disease, I have found a predominance of progesterone receptors. Often in the same patient, there will be different receptors in different areas. Many times fibroblasts and mesothelial cells will be positive for hormones. My thoughts are that maybe these cells are deeper, and precursors to glands and stromal cells. The other aspect is that it does not seem to matter whether the patients are on artificial hormones, where they are in their cycle, or menopausal without hormones. My pathologist has found that progesterone receptors are usually highly positive versus less for the estrogen receptors. This is over thousands of patients I have found these results. The idea to do this was given to me by Mr Jeremy Wright from the UK. What does this mean for patients? Instead of making the assumption that estrogen makes this disease grow, we will then know what makes it grow. I was always taught that avoiding estrogen will stop this disease, and using progesterone will be beneficial. Progesterone is the PMS hormone, and if on it for a a year, the patient may have as much bone density loss as if in menopause for a year. I also was taught that using birth control pills (BCP) are the answer. I saw so many patients that have had significant side effects from the BCP, and the disease was growing, that I knew something did not make sense. The WHI (Women’s Health Initiative) looking at breast cancer, and it’s response to hormones was the instigator in looking at receptors for endometriosis. By the way, 65% of breast cancers are positive for both estrogen and progesterone. Conversely, breast cancer’s next most common receptors are estrogen, but it is progesterone (after both) in endometriosis. So, post surgery, patients may want to evaluate their receptors so they know what would be best for them. I know the thought is “all the disease” is removed by experts, but I have found fibroblasts and mesothelial cels that are positive to hormones, and these may be deeper precursors to glands and stromal cells (the 2 components of endometriosis). This may mean that even after all the disease is gone, there may be patients that could possibly have disease present after excision. Not saying it is for sure, but it is a possibility. The other issue is adenomyosis. I don’t get receptors in the uterus, as I would expect uterine cells to be positive for estrogen and progesterone. Maybe this is something to also be evaluated in the future. Some people wonder about the cost. Insurance companies do pay for these studies, including medicaid and medicare. They are easy to order during surgery. the surgeon just directs the nurse to order it on the specimens. Not too difficult. Fir the doctors that do not do this, I urger you “PLEASE, JUST TRY IT”. You will be amazed.“

Chloroindazole http://www.chemspider.com/Chemical-Structure.9291381.html

Oxabicycloheptene https://www.ncbi.nlm.nih.gov/pubmed/28374135

Chloroindazole & Oxabicycloheptene for treatment of Endometriosis http://www.medicnewsweb.com/endometriosis-treatment-drug/

Dr.cooks website (explains endometriosis, symptoms, treatments, and more) https://www.vitalhealth.com/endometriosis-specialty-center/learn-about-endometriosis/

Information on Lupron

https://www.statnews.com/2017/02/02/lupron-puberty-children-health-problems/

Dr.Sinervo's website Center For Endometriosis Care: http://centerforendo.com/resources/

#endometriosis #endometriosis education #endendo #chronic illness #chronic pain #chronically awesome

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urologistinnoida · 4 years

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Urethral Stricture: Causes and Treatment

The urethra is a tubular organ through which urine flows out of the bladder.

In men, the urethra is longer. In its innermost part, just at the exit of the bladder, the urethra crosses the prostate.

Near the exit of the bladder is the urinary sphincter, which controls the voluntary elimination of urine (continence).

Any part of the urethra can be affected, and the extent of the narrowing can vary from a few millimetres or even affect the urethra throughout its length. In general, there is deposition of scar tissue (fibrosis) in the region of the stenosis. This type of problem is more common and more complex in men, says the urologist in Noida.

Causes

Trauma or urethral lesions that, when healing, can determine an excessive deposition of fibrotic tissue, causing a decrease in the calibre of the urethral canal. There are several types of trauma capable of injuring the urethra: pelvic fractures, "fall to rider" (which occurs, for example, when the person has a bicycle accident and traumatizes the perineum region). Medical procedures with urethral manipulation (cystoscopy, prostate surgery, passage of urethral tubes, among others) and even radiotherapy can also produce strictures, even when done properly, says the urologist in Greater Noida.

Infections such as urethritis caused by sexually transmitted diseases (gonorrhoea or chlamydia). Even with the proper treatment and cure of the infection, the healing process resulting from tissue inflammation can cause strictures.

Congenital - some new-borns are already born with stenosis.

Cancer is a rare cause of stenosis. The primary tumour is usually located in the prostate or bladder.

Symptoms

Reduced flow of urine is usually the first symptom. Voiding difficulty is quite common, but complete interruption of flow is rare.

Spread or double jet.

Urine drip after urination.

Increased urination frequency (need to urinate more often than usual).

Nycturia (waking up and getting up at night to urinate).

Burning at the time of urination.

Urinary incontinence in some cases.

Complications

When you have a urethral narrowing, the bladder muscle starts to work, making more effort to generate a urinary flow that can overcome the region of stenosis. Even so, depending on the degree of the stenosis, part of the urine may be retained inside the bladder (residual urine). This residue can result in recurrent urinary infections, prostatitis, orchitis (infection of the testicles) and pyelonephritis (infection of the kidneys). An abscess near the site of the stenosis can further aggravate the obstructive condition. Rarely, some patients with chronic inflammation due to urethral strictures can develop cancer, states the best urologist in Greater Noida.

Tests for detection of urethral stenosis

Urofluxometry - Evaluation of the force of the urinary stream, which is obtained when the patient urinates in a device that measures the flow of urine (ml / s). Stenoses determine decreased flow.

Urethrocystography - Examination in which x-ray plates are made with the urethra filled with contrast. Thus, the location and extent of the narrowing can be determined.

Cystoscopy - Examining the region of the stenosis with a special endoscope may be indicated in some cases.

Treatment

Urethral dilation - Type of outpatient treatment. The region of the stenosis is dilated with the use of progressive gauge plastic urethral tubes. The objective of this method is to try to supply the fibrotic tissue of the stenosis in order to increase / stabilize the internal diameter of the urethral canal. As the urethra is a tubular organ and the scar tissue tends to contract, repeated dilation sessions are generally necessary to maintain the urethral lumen. Some patients learn to self-dilate when the procedure has to be performed at very short intervals. The dilations can be used as an initial treatment in short and mild stenosis, or even in the post-surgical period to stabilize the operated segment, explains the urologist in Ghaziabad.

Urethrotomy - A special type of endoscope (called a cystoscope) is introduced through the urethra to the site of the stenosis. A small blade embedded in the device cuts the fibrosis region along the stenotic segment, thereby increasing the light of the urethra. Although most patients improve their symptoms for some time, only about 30% are definitively cured with this type of procedure. Therefore, many end up having to repeat the urethromia from time to time. It is an attractive method because it is performed in a non-invasive endoscopic way. It is more suitable for relatively short strictures (less than 1.5 cm), says the best urologist in Ghaziabad.

Surgery - It may be an option to the treatments mentioned above. There are several different types of techniques. For relatively short stenoses, the stenosed urethra can be removed and the urethral stumps are again joined with suture points. If the stenosis is long, skin flaps from the region (for example, a foreskin flap) can be rotated to replace the diseased foreskin segment. These procedures have a higher success rate.

Urethral stents - Used in difficult and complex cases when other types of treatment have had no effect or when the patient's clinical conditions prevent major surgery. Immediate relief is usually obtained, however, over time, fibrotic tissue progressively surrounds the stent, says the urologist in Delhi.

#Urologist in Noida #Best Urologist in Noida #Urologist in Greater Noida #Urologist in Ghaziabad #Best Urologist in Greater Noida #Best Urologist in Ghaziabad

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anamorales · 5 years

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Friday Faves

Here are some faves from the week and around the web. I always love hearing about your faves, too, so please shout out something you’re lovin’ in the comments.

Adventures from lately:

Read, watch, listen:

Definitely check out this week’s podcast episode about plastic surgery! This was one of my highest-downloaded episodes yet, and it’s a fun one.

12 book suggestions.

What we can do about climate change.

Fitness:

Easy ways to calm pre-race nerves.

What to eat before and after a long run.

Good eats:

Skinnytaste turkey pumpkin chili (one of my fave fall recipes!),

and Kyle brought over the best green goddess salad from August Rhodes. Nani brought pumpkin pie.

It was an epic feast and the kiddos all ran around playing while the adults drank wine and chatted. The only thing missing was the Pilot, but it was a pretty great night.

You need these brownies in your life.

Easy pumpkin spice granola.

Still loving this chickpea scramble.

Just for kicks:

The Pilot sent this to me and I cried a little laughing.

Happy Friday! Thanks so much for stopping by the blog today. <3

Gina

The post Friday Faves appeared first on The Fitnessista.

Friday Faves published first on https://immigrationways.tumblr.com/

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