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Nucleus AI Review – Get 22+ Premium Ai tools just one time fee.
Nucleus AI Review - Get 22+ Premium Ai tools just one time fee
Nucleus AI is an app that gives you access to over 22+ premium AI tools with just a one time low price. Including ChatGPT 4o, Google Gemini Pro, DallE AI, Whisper AI Text to Speech, Microsoft Copilot Pro, Midjourney Mega, Leonardo AI Pro, Meta Llama Pro, and much more 22+ premium AI Tools. This is all in one solution for AI tools. After purchasing Nucleus AI you don’t need to waste 1000s Of Dollars for purchasing too many AI Tools.
>>>>GET ACCESS NOW<<<<
What is Nucleus AI?
In today's tech driven world, AI is truly revolutionary. It empowers people to automate tasks, making everything from coding to real life problem solving faster and easier. That’s why there are too many AI tools available. If you're not using AI, you'll quickly find yourself falling behind in the ever evolving tech landscape.
There are many AI tools available for free, but with the free versions, you typically get limited access. To work more efficiently and professionally with AI, you'll likely need to purchase the premium version, which can be quite expensive. Nucleus AI solves this problem by offering all the premium AI features you need in just one tool. The best part is that Nucleus AI is priced affordably, so you don't have to buy multiple expensive AI tools.
Overview of Nucleus AI
Creator: Radu Hahaianu, Mike Mckay, and Calin Ioan
Рrоԁuсt: Nucleus AI
Official Site: Click HERE
Price: Today- $14.90
Recommendation: Highly Recommend
Niche: AI
Risk Free: 30 Days Money Back Guarantee
>>>GET ACCESS NOW<<<
So, Let’s talk about the features of Nucleus AI?
First of all, Nucleus AI solves your money problem, you don’t need to buy individual AI Tools from different platforms. With this Nucleus AI you can use it unlimited times. There is no limit.
Instant access to 30 of the best premium AI tools for a one-time fee
Save up to $300/month while using the most powerful AI tools, all from one simple dashboard
Includes top AI tools like ChatGPT 4.0 Plus, Google Gemini Ultra Advanced, DALL·E HD, Whisper AI Text-to-Speech, Midjourney Mega, Microsoft Copilot Pro, Leonardo AI Pro, Meta Llama 3.1, and 22 other premium AIs
Write unlimited, unique content with ease
Code apps from cloud software to mobile apps, and even WordPress plugins
Build full affiliate websites effortlessly
Create stunning HD videos and generate graphics & images
Convert any text into lifelike, human-sounding speech
Generate music that could top the Billboard charts
Manage your social media accounts like a pro
Clone any voice and set up talking avatars
Rank #1 in SEO with powerful backlink strategies
Run live chatbots for customer support & sales
Create Hollywood-level movies with ease
WordPress integration lets ChatGPT automatically publish daily affiliate articles on your blog
YouTube integration means Gemini Ultra Advanced can create YouTube Shorts and daily vlogs with just one click
Social media integration allows Meta Llama 3.1 to message people on Instagram and WhatsApp for you
Autoresponder integration means Microsoft Copilot Pro will write and send email newsletters 24/7
How can Nucleus AI help you?
Nucleus AI helps you to save your money. With this you can create amazing high quality videos, you can build your entire website using this Nucleus AI. Not only that, Nucleus AI also helps with like Code any type of app, from cloud software and mobile apps to WordPress plugins, Generate High Quality AI Images & Graphics, You can make turn any text into human sounding natural voice, You can create musics using this Nucleus AI Software.
Nucleus AI also has AI Based social media accounts management features. So you don’t need to check all your social media accounts. This tool Already has Autoresponder integration means Microsoft Copilot Pro will write email newsletters for you 24/7. There lot’s benefit of this Nucleus AI. You can create entire Hollywood polish movies, It’s ready to publish.
Where are your benefits right?
The benefit is easier to work systems using AI features of Nucleus AI. For example before you manually manage your business or personal social media rights? After using this, you don’t need to manually check your social profiles. You don’t need to answer your customer's question. This Nucleus AI automatically answers questions. Also, you don’t need to create images and videos for your social media. These tools handle everything for you. From creation to posting and answering cutomeser’s asked questions. You Don’t to hire a social media manager, it saves your money.
If you’re someone who wants to create a website. But you don’t have the money. So this Nucleus AI also solves this problem. It will create your website with just one click, you just need to do Instruction. No prior skills required.
Nucleus AI is a game changing tool that saves you money, saves you time, and helps you make money. It’s your partner in building a business from the ground up, boosting sales, and even ranking your website on the first page of Google. So why waste any more time? Start using Nucleus AI today.
How Does Nucleus AI Work?
Nucleus AI works In 3 Simple Steps:
STEP 1:
Login Inside Our Nucleus Cloud Dashboard
(Accessible from anywhere in the world: Mac, PC, Mobile)
STEP 2:
Select One Of The 30 Built-In Premium Ais and Services:
(Unlimited use content, coding, affiliate websites, HD videos, graphics, images, text-to-speech, music, books, social media, voice avatars, SEO, chatbots & even movies)
STEP 3:
Enjoy Better Features And Superior Service Than Ever Before With Zero Monthly Fees:
(All premium Ais inside ONE single dashboard with direct integration to WordPress, Youtube, Social Media & Email Autoresponders for 1 click publishing)
What can you achieve with Nucleus AI?
With Nucleus AI, you can automate tasks, boost your online sales, create content for your business, rank on Google, manage social media, and much more helping you grow your business and save time and make more money.
Some of user who uses Nucleus AI in their business here is the result
Who is Nucleus AI for?
Anyone who wants to switch from monthly or yearly AI subscriptions to a one-time payment.
Anyone who wants to save money without compromising on quality.
Anyone who wants to get started with AI in the easiest and most cost effective way.
Anyone who wants the same or better features than their competitors.
Anyone tired of free AI versions that make you a prompt master, just to get useful results.
Anyone fed up with all-in-one AI tools that are nameless, faceless, and vanish after a month.
Anyone who values security and privacy and wants to keep their sites, files, emails, and data encrypted and protected.
Any website owner or online marketer.
What You Get Today with Nucleus AI?
Total values you getting $19,980
In a package Nucleus AI with just: $14.90
Nucleus AI is Risk Free?
Yes, It’s totally risk free. 100% Guaranteed back your money.
In the rare case that you experience any technical issues we can't resolve quickly, we'll offer you a full refund.
No hassle – 100% risk-free.
Pricing of Nucleus AI?
One of Nucleus AI's strong points is its affordability. It is quiet available in cheap price.
Regular Prices: $197
Today: $14.90
>>>BUY NOW<<<
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Nucleus App Review – All-in-One Complete AIs Solution Just a One-Time Fee
Welcome to my Nucleus App Review. Artificial intelligence (AI) has now been integrated into the society with most especially in the business, creation and individual’s activities processes. From creating content to handling projects, AIs are changing how work, think, and create. However, to use the most advanced AIs such as ChatGPT 4, Google Gemini, DALL-E HDs and others, they require a subscription or are very costly once used on a pay-as-you-go-layer.
This is where Nucleus comes in as a new generation solution. Nucleus presents a solution which not only is unique, but which is incredibly cheap as well. It is hard to even comprehend the range of capabilities when you have free lifetime access to over 30 best of the best AIs; we are talking here about such heavy weights as ChatGPT 4o Plus; Google Gemini Ultra Advanced; DALL-E HD; Whisper AI Text-to-Speech; Midjourney Mega; Microsoft Copilot Pro; Leonardo AI Pro; Meta Llama 3.1 and even more. Nothing is free, right, but that’s not true here; no monthly fees.
Here is our detailed review where we will cover the main features of Nucleus; the advantages of having an option of accessing the best AIs without limits; the prices, as well as the answer to the question of whether it is worth investing in the platform.
What Is Nucleus App?
Nucleus is an all-in-one cloud-based platform that provides access to 30 ultra-mainline additional AI applications with a single purchase which provides lifetime access. It centralizes state-of-art AI functions in different groups of AI services such as NLP, image AI, TTS, video AI, and data AI. The only rich text editor tools in the world that can be combined to take advantage of Nucleus are ChatGPT-4o Plus, Google Gemini Ultra Advanced, Dall-E HD, Midjourney Mega, and Microsoft Copilot Pro and Nucleus is built to make users more effective and creative through ‘ this unique combination and freeing them from the pain of being charged monthly for tools which are critical for their productivity and creativity. Freelancers, marketers, and small businesses can reap the benefits of using Nucleus to achieve the access to cutting-edge AI tools and technologies without overpaying.
Nucleus App Review: Overview
Product Creator: Mike & Radu
Product Name: Nucleus
Launch Date: 2024-Oct-12
Launch Time: 11:00 EDT
Front-End Price: $17 (One-time payment)
Official Website: Click Here To Visit Official Salespage
Product Type: Tools And Software
Support: Effective Response
Discount: Get The Best Discount Right Here!
Recommended: Highly Recommended
Bonuses: YES, Huge Bonuses
Skill Level Required: All Levels
Discount Coupon: Use Code “NUCADMIN30” To Get 30% OFF!
Refund: YES, 30 Days Money-Back Guarantee
Nucleus App Review: About Authors
Nucleus is brought to you by the masterminds Mike and Radu. Mike, with his extensive experience in software development and user interface design, has made Nucleus both intuitive and powerful. Radu, an expert in premium Ais tool and business automation, has integrated advanced features that effortlessly drive traffic and maximize sales.
His interest in technology that changes the game goes beyond this release. There are great items in his collection, such as ProfitList, ProfitCodex, ProfitWPH, ProfitStays, ProfitShopper, ProfitSpark, ProfitSoci, ProfitSGE, ProfitMarc, ProfitClass, ProfitCom, ProfitReply AI, ProfitAudio, ProfitTok, ProfitTV, ProfitTurbo, ProfitChat, GPT eBook Pack, ProfitLens, ProfitEngage and many others.
Nucleus App Review: Key Features of Nucleus App
Harness The Power of Multiple AIs Via Nucleus, Your Central Hub For Intelligent Automation!
Switch Between Different AI Models To Tackle Any Challenge With Accuracy & Precision!
Minimize Distractions & Stay Focused With Nucleus’ AI-Powered Focus Mode Feature!
Integrate External Chatbots Effortlessly Into Your Workflow, Making Nucleus Your AI-Central!
Train Multiple AI Assistants Simultaneously For Specific Tasks & Roles!
Manage Multiple AI Deployments With Ease Using Nucleus’ Advanced Plan Management System!
Tap Into OpenAI’s GPT Models to Provide Intelligent, Real-Time Answers For Your Customers!
Capture Professional-Grade Product Photography With Nucleus’ AI-Based Photo Generation!
Experience Crystal-Clear Conversations by Leveraging AI Voice-Isolation Technology!
Share Conversations Across Teams With Nucleus’ Collaborative AI-Sharing Feature!
HubSpot Integration Ensures Your Sales & Marketing AIs Work Together Seamlessly!
Connect Nucleus With Multiple ARs For AI-Driven Email Marketing Campaigns!
Continuously Improve Your AI Assistants With Specialized Training Tools & Analytics!
100% Newbie-Friendly, Easy-To-Use Software!
Utilize AI-Powered Image Generation to Create Stunning Visuals!
Sign Up For Important Launch And Leaderboard Updates
Click The Button Below To Grab Your Warrior+ Affilaite Link
Full Commercial Rights – Offer This Incredible Service To Clients!
100% Newbie-Friendly, Easy-To-Use Software!
Perfect For Affiliates, eCom Sellers, Offline…Everyone!
24/7 Support From Marketing Experts!
Nucleus App Review: How Does It Work?
Get Everything & Much More For A One Time Fee In 3 Simple Steps
Step #1: Login inside Our Nucleus Cloud Dashboard (Accessible from anywhere in the world: Mac, PC, and Mobile)
Step #2: Select One Of The 30 Built-In Premium AIs and Services (Unlimited use content, coding, affiliate websites, HD videos, graphics, images, text-to-speech, music, books, social media, voice avatars, SEO, chatbots & even movies)
Step #3: Enjoy Better Features and Superior Service than Ever before with Zero Monthly Fees (All premium AIs inside ONE single dashboard with direct integration to WordPress, Youtube, Social Media & Email Autoresponders for 1 click publishing)
Nucleus App Review: Benefits of Nucleus App
Automatically Route Tasks To The Best-Suited AI Model, Optimizing Efficiency in Real-Time!
Personalize Every Interaction by Leveraging Customizable AI Chatbot Themes!
Get Insights & Track Performance Across Multiple AIs With Real-Time Reporting!
Automate Repetitive Tasks by Distributing Workloads Across Different AI Engines!
Cloud-Based Platform That Keeps All Your AI Tools Accessible From Anywhere, Anytime!
Leverage The Latest AI Models & Updates to Ensure Your Solutions Remain Cutting-Edge.
Centralize All AI-Related Operations in One Intuitive Hub, Giving You Full Control Over Automation!
Nucleus Has Been Fully Tested By Us So 100% Proven to Work!
Trust In Our Cutting-Edge Tech Which Provides The HIGHEST Level Of Security & Performance!
Nucleus Will Give Customers The Best AI Experience Possible!
All-In-One Software Proven To Make Money Online!
NEVER BEEN DONE BEFORE!
Verify Users Say About Nucleus App
Nucleus App Review: Who Should Use It?
Affiliate Marketer
Business Owners
Coaches/Trainers
Website Owners
Product Creators
SAAS Owners
Video Marketer
E-Com Seller
Webinar/Seminar Presenter
Freelancers
Agency Owners
Newbies
Digital Marketer
Website Owners
Product Creators
SAAS Owners
Nucleus App Review: OTO’s And Pricing
Add My Bundle Coupon Code “NUCADMIN30″ – For 30% Off Any Funnel OTO Below
Front End Peice: Nucleus ($17)
OTO 1: Nucleus PRO ($32.90)
OTO 2: Nucleus Enterprise ($62.90)
OTO 3: Nucleus DFY ($39)
OTO 4: Nucleus Reseller ($197)
OTO 5: Nucleus IMX ($97)
My Own Customized Exclusive VIP Bonus Bundle
***How To Claim These Bonuses***
Step #1:
Complete your purchase of the Nucleus: My Special Unique Bonus Bundle will be visible on your access page as an Affiliate Bonus Button on WarriorPlus immediately after purchase. And before ending my honest Nucleus Review, I told you that I would give you my very own VIP Bonus PFTSES formula for Free.

Step #2:
Send the proof of purchase to my e-mail “[email protected]” (Then I’ll manually Deliver it for you in 24 HOURS).
Nucleus App Review: Demo Video
Just Watch Nucleus App Down Below To Get All The Details:
Nucleus App Review: Money Back Guarantee
Guaranteed Or Your Money Back – 100% Risk Free
Enjoy Nucleus for 30 days by purchasing it now. You will receive a refund if, in the improbable event that we are unable to promptly resolve any technical problems you have. 100% risk-free with no hassles.
Nucleus App Review: Pros and Cons
Pros:
Unlimited access to over 30 premium AIs
One-time low payment
Comprehensive suite of tools for various use cases
Cost-effective for businesses and individuals
Easy-to-use platform with a user-friendly interface
Cons:
Requires a one-time investment
To use this product, you must have internet access.
Nothing wrong with it, it works perfectly!
Frequently Asked Questions (FAQ’s)
Q. Is Nucleus cloud-based?
Yes, Nucleus is a cloud-based hosting solution easy to access from anywhere. Works with Mac, PC and mobile.
Q. Does Nucleus cost a monthly fee?
When you act now, you’re getting one-time access to Nucleus without EVER having to pay a monthly fee 🙂
Q. Are others using Nucleus already?
Yes – we are serving over 10,000 happy customers already. Some of their feedback is being represented on this very page above. We’ve been in this business for MANY years and are here to stay.
Q. Do I need any tech skills or experience to make this work?
NO – Nucleus is seamless and 100% newbie friendly.
Q. Is Support & Training Included?
Absolutely. By purchasing today you can get instant access to the training portal and the 24/7 support desk.
Nucleus App Review: My Recommendation
Therefore, Nucleus is an industry revolutionizing platform that opens up the option of applying highly sophisticated AI strategies to the broader public. The fact that it’s a one-time payment product and has access to so many powerful tools, it’s easy to recommend to anyone looking to get in on the AI trend. Nucleus is a way to work with some of the best AI today all bundled into one package for a reasonable price.
>>> Click Here to Visit Nucleus and Get Access Now <<<
Check Out My Previous Reviews: AI Supreme Review, Click Paydays Review, AI MovieMaker Review, Topaz App Review, Blaster Review, and 6SiteAI Review.
Thank for reading my Nucleus App Review till the end. Hope it will help you to make purchase decision perfectly.
Disclaimer: This review is based on available information and user experiences. Individual results may vary. It’s recommended to conduct thorough research and due diligence before making any investment decisions.
Note: This is a paid software, and the one-time price is $17 .
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New “Nucleus Premium AI Suite
Get Unlimited Chat GPT 4o Plus, Google Gemini Ultra Advanced
DallE HD, Whisper AI Text-to-Speech, Mid journey Mega, Microsoft Copilot Pro, Leonardo AI Pro, Meta Llama 3.1 and 15 Other Premium AIs For A Low One Time Price
Brand New “ Nucleus Premium AI Suite” Is The Last Purchase You’ll Ever Need To Make Online!
More Info
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ROBOT ID PACK
NAMES ︰ aerobot. agatha. ai. alan. alethea. alexia. algernon. alistair. alpha. amaryllis. ambrose. androbot. androic. andromeda. angelica. antenna. arabella. araminta. arcade. auto. automaton. axel. axis. badnik. bionel. bolt. byte. care. celline. cello. chip. chipique. clank. cloniste. clonoid. cobot. codelle. cole. curiosity. cy. cyber. cybette. cybion. cypher. data. dell. della. delpha. delta. digi. dot. droid. droidess. droidis. dronette. echo. elektra. euna. eva. eve. fritz. giga. gizmo. glitch. grey. gynoid. helix. holo. holodir. hydra. ida. jet. kaput. kinect. krudzu. linion. mac. mace. machibella. machina. mal. malware. mation. mech. mecha. mechael. mechan.ace. metal. metalia. metalish. micro. motherboard. motor. nano. neo. nucleus. nyquist. orbit. parallel. pip. pixel. prime. primus. proto. quantum. radar. radius. ram. ray. reflect. reflectette. robo. robonaut. rusty. satellite. scrappy. selsyn. sentiex. servo. shard. siri. solar. sonar. spark. sparkie. sparky. sputnik. steele. sterling. stochastic. synchro. synie. synthett. talus. terra. tin. tink. tobor. ultramarine. ultron. unimate. unit. virus. waldo. zip.
PRONOUNS︰ ai/ai. algo/algorithm. android/android. app/app. auto/auto. auto/automated. auto/automaton. axis/axi. beep/boop. bio/bionic. bio/bioplastic. blast/blast. bo/bot. bolt/bolt. bot/bot. buffer/buffer. byte/byte. cell/cell. chaos/chaos. chi/chip. click/click. clo/clone. code/code. coil/recoil. command/command. compute/computer. core/core. cyb/cyborg. cyber/cyber. data/data. dev/device. device/device. dig/digital. digi/digital. droi/droid. droid/droid. e/exe. electric/electric. entry/entries. exo/exoskeleton. gear/gear. gli/glitch. glitch/glitch. hack/hack. ho/holo. holo/holo. hologram/hologram. in/install. intra/intranet. link/link. machi/machine. mal/malfunction. mal/malware. mech/mech. mecha/mechanical. mechanic/mechanic. metal/metal. metro/metro. motor/motor. neo/neo. neon/neon. nuclear/nuclear. propeller/propeller. radar/radar. retro/retro. robo/robo. robo/robot. robot/robot. rubber/rubber. satellite/satellite. sca/scan. shard/shard. shine/shiny. signal/signal. solar/solar. steel/steel. stem/stem. swi/switch. syn/synth. syn/synthetic. tech/tech. techno/techno. test/test. text/text. turing/turing. vi/viru. web/site. web/web. whirr/whirr. wi/wifi. wire/wire. wired/wired. ⚙️/⚙️. 🔧/🔧. 🔩/🔩. 🛠//🛠. 🤖/🤖.
#pupsmail︰id packs#id pack#npt#name suggestions#name ideas#name list#pronoun suggestions#pronoun ideas#pronoun list#neopronouns#nounself#emojiself#robotkin#machinekin#androidkin#robotcore
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Weekend links, May 4, 2025
My posts
I am still struggling with the fifth Silent Hill 2 commentary; the video I recorded last week (4/30) also isn't usable. Like, maybe I'll post it on Patreon as an extra at some point, but it is not the level of excellence we strive for here at Cleolinda Industries. Within hours of that, April's parting shot was to knock me down with another head cold, BUT, now that I have escaped its grip (April's, not the cold's. I'm still sick), I may have solved my OBS problems. I DON'T KNOW. WE LIVE IN HOPE.
Meanwhile, Ian's off in fuckin' Brookhaven Hospital. IT'S. FINE. (I'm in the chat, we figure out some good stuff about the lore, it's a good time.) Also, at the top of his stream, he had sound engineer Andy Sudol on to talk about the differences between the 2001 and 2024 soundtracks.
Signal boost while we're talking about games: I'm doing really well on light combat in SH2, except for when my neuropathy acts up and my fingers just decide they don't want to participate anymore (it's a good bet this has happened if I start screaming "JAMES WHAT ARE YOU DOING??"), so these mods and resources for disabled gamers caught my eye.
Reblogs of interest
@mamoru looking out for us on the food safety front
Y'all, I don't know what's going on with Pinterest, but don't breathe too hard right now. An update from Reddit: More news outlets are reporting the sudden mass ban wave these last two weeks
My personal question: how does it actually BENEFIT companies to make their product unusable, though? I understand the answer, and yet, as a person who can think more than five seconds ahead into the future, I completely do not understand the answer.
This question was also partly inspired by Polygon getting sold/gutted, in the sense of this Reddit reply.
Oh, I wasn't even thinking of Duolingo asserting itself as an "AI-first" company even as people complain that the quality of the app has plunged, so fuck them too I guess
PSA about some scam call techniques
I had to tell my therapist that I was facetiously done with life and everything in it, so I get this post
Good (and cute) news: "you can sponsor your own big beautiful TB- or landmine-detecting rat through APOPO HeroRATS"; "First-of-its-kind lab breeds bumblebee babies to save species from extinction"
Zines: I Am Not Your Asian American Doll
Speaking of Silent Hill 2: "this is how tag searches feel"
"askjeeves how to smuggle 30 naked prisoners (assorted genders) out of vampire mansion time sensitive."
"no, you’re thinking of fusion and fission. Bisexuals result in two nuclei that are identical to the original nucleus. Pansexuals result in four nuclei with half the number of chromosomes of the original cell"
"oh to be the black blob of a cat in vanessa stockard's paintings"
In tough times, there is one thing thou must always remember
All of these are horses
"Goblin learns they have a racist sword": some fantasy ideas
Flip the Frog gets restored
I'm particularly amused by these Vanillary reviews because I have it as a solid perfume and it's fine.
I agree with all of these expletive/accent pairings.
A feline boo ghost to go with last week's ghost dog photoshoot
"The tribes of Tumblr appeared to worship Apollo as their primary patron deity, most often under the epithet Apollo Spairahemon ('Apollo the Ball-Thrower')"
Video
Wet beast Wednesday: "MOVE IDIOT"
Blumineck has a new approach to the three-arrow trick shot
"i know this is a predator. like a hardened killing machine. tempered by hundreds of years of evolutionary prowess to fine tune him into a living weapon. but"
Finsync
Good guy who talks like a bad guy
I honestly was not prepared for anything in this anecdote about buying a printer
The sacred texts
The iconic "girl… what were YOU doing at the devils sacrament 👀"
Personal tags of the week
I will be adding to "with mama" as often as possible. (You know what? I also need to add to dragons.)
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You:
explain crispr mRNA
Ai:
CRISPR RNA (crRNA) is a sophisticated, programmable molecular tool that leverages the prokaryotic adaptive immune system's mechanism of defense against invasive genetic elements. This RNA-based component serves as a guide to direct the Cas9 nuclease enzyme toward specific genomic loci for targeted editing.
The crRNA structure consists of three distinct regions: the scaffold, the repeat sequence, and the protospacer. The scaffold provides structural support and facilitates binding with the Cas9 protein, while the repeat segment is derived from the CRISPR array in the bacterial genome and promotes crRNA-Cas9 complex formation.
The protospacer region, which constitutes the majority of the crRNA sequence, harbors the desired target specificity information. It possesses a complementarity to a predefined genomic sequence (the target site), thereby enabling the crRNA-guided Cas9 endonuclease to recognize and cleave the target DNA at the precise location.
crRNA synthesis typically involves in vitro transcription from a DNA template or ribosomal RNA processing in vivo. The resulting mature crRNAs are then processed into their functional forms through 5' and 3' trimming, which removes non-essential regions and generates a single-stranded structure that can base-pair with the target site.
Upon binding to Cas9, the crRNA acts as an adaptor, positioning the nuclease at its cognate genomic location. Upon encountering the target sequence, the Cas9-crRNA complex excises the DNA, creating a double-strand break (DSB). The DSB can then be repaired by the cell's endogenous pathways, which may result in precise gene editing via homology-directed repair (HDR) or introduce insertions/deletions (indels) through non-homologous end joining (NHEJ), effectively creating a mutation at the targeted site.
The programmable nature of crRNAs allows researchers to tailor them for specific applications, including gene knockouts, point mutations, and even precise base editing. Moreover, advances in RNA engineering have enabled the development of complex crRNA designs capable of targeting multiple genomic loci simultaneously or recognizing non-canonical target sites.
In summary, CRISPR RNA is a highly specialized, versatile molecular tool that empowers scientists to precisely manipulate genomes through its intricate interactions with Cas proteins and cellular repair machinery. Its unique properties have revolutionized the field of genome engineering, offering unprecedented control over genetic information.
You:
explain how a virus can be used as an mRNA encapsulate to deliver crisper RNA
Ai:
Viruses, particularly those in the families Lentiviridae (e.g., HIV-1), Adenoviridae (e.g., adenovirus serotype 5), and AAVidiae (adeno-associated viruses), can be engineered to function as mRNA encapsulation vectors for CRISPR RNA delivery.
The process typically involves:
Cloning the desired crRNA sequence into an expression plasmid, which is then transfected into virus-producing cells. The viral vector is assembled with its capsid protein and genomic RNA, replacing the original viral genetic material. The modified virus acquires the CRISPR RNA as a passenger payload, encapsulated within its lipid envelope or protein capsid. Upon infection of target host cells, the virus delivers its crRNA cargo into the cytoplasm via endocytosis and lysosomal escape. After entering the nucleus through nuclear pore complexes, the released crRNA can then interact with Cas proteins to initiate genome editing at the desired loci.
The choice of viral vector largely depends on factors such as host specificity, transduction efficiency, and immunogenicity concerns. Lentiviral vectors, for example, are capable of infecting non-dividing cells but may elicit stronger immune responses compared to AAV or adenoviral alternatives. AAVs, being less immunogenic, have become popular choices for gene therapy applications.
Incorporating CRISPR RNA into viral delivery systems offers several advantages over direct crRNA administration. It enables targeted and efficient transduction of cells, enhances the stability of crRNA in circulation, reduces off-target effects due to improved tissue specificity, and can facilitate simultaneous editing or multiplexed gene modifications.
However, challenges persist, including concerns over potential off-target effects from viral-mediated delivery itself, immune responses against the viral vector, and the need for further optimization of viral design and packaging strategies to ensure precise genome editing with minimal collateral damage. Continued research is necessary to refine this approach and maximize its therapeutic potential in various applications, ranging from treating genetic diseases to agricultural biotechnology.
————————————————————————
Virus AI describes as being the likely candidate for spreading crisper RNA

“A digital cryo-electron micrograph of the Adenovirus serotype 5 (Ad-5)/HVR5-33RGD vector. Adenoviruses are non-enveloped, double-stranded DNA viruses that cause cold-like infections of the upper respiratory tract.”
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hello! might i ask for some robot themed npts? :3c
of course ! 🧪 hope these are alright! some of these are references to robots/ai in media I'm familiar with, hope you don't mind that.
robot themed npts (names pronouns and titles!)
names 🥼
metal, tin, glitch, AI, neo, alan, giga, motherboard, shard, badnik, krudzu, satellite, solar, nucleus, ultramarine, auto, aerobot, axis, delta, cobot, care, hydra, andromeda, gynoid, automaton, holo, kinect, nyquist, parallel, radar, servo, sonar, stochastic, waldo, unimate, synchro, selsyn, motor, robonaut
pronouns 🥼
turing/turing, bio/bioplastics, data/data, rubber/rubbers, coil/recoil, stem/stem, steel/steels, propeller/propellers, bot/bots, shine/shiny/shines, signal/signals intra/intranet, command/commands, entry/entries, metro/metros, retro/retros, neon/neons, core/cores, test/test, text/text, buffer/buffers, chaos/chaos, blast/blasts, nuclear/nuclear, 10110/101s, code/codes, algo/algorithms, exo/exoskeletons
titles 🥼
(prn) who needs repairs, (prn) who tangled (prn) in wires, the one trapped inside a cybernetic dream, the one with the antenna, the professors greatest creation, the one with the faulty program, the new and improved (name), (prn) who has cold metal hands, (prn) who is sending out a signal, (prn) with bombs for throwing at you, (prn) who is one of the Aperture Science Personality Constructs, (prn) with the opera singer turrets/oracle turrets/defective turrets, the robot at the top of the tower, the one who requires the four thangs, the one with many powers, (prn) who is revolutionary, the metal overlord, mecha (name) mark II, the winner of robocup, the singularity, the robot deep in space
hope these are to your liking, thank you for requesting the SRL!
#the labs finest creations ! requests / non requests#npt#npts#npt pack#request#mogai#liom#npt ideas#robot#robotics
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Hello, I am loving Ts' Íts' àsh and how it’s spoken! I’d love to know if you plan on releasing a full breakdown/alphabet type thing because I would love to learn more about it and how to speak it! I’m already learning parts of it and implementing it into my daily speech to get better at speaking it, especially ashfa. Would love to learn more soon!
Best regards, Samuel
If you're talking about the orthography, I did that here. If you mean the sound system and the romanization, I can do that.
Ts'íts'àsh doesn't have a ton of consonants—very few, in fact. They are as follows (romanized form [IPA]: notes [if any]):
p [p]
b [b]
t [t]
d [d]
t' [t']: this is an ejective consonant
k [k]
k' [k']: this is also an ejective consonant
f [ɸ]: this is a bilabial sound
s [s]
sh [ʃ]
kh [x]
r [r/ɾ]: pronounced like a trill at the beginning or end of a word; otherwise pronounced like a flap
That's it! Nothing too complex. Then there are only four true monophthong vowels:
a [a]
i [i]
o [o]
u [u]
Now this is where things get complicated. Any of the four vowels above or any of the fricatives above can serve as a nucleus. This means you can have a word tkh, psh, or even ss. All of those are licit. You can also have any two vowels in a nucleus—including the fricatives. So while you can only have CVV, you can actually have words like tsá, kshí, or even pskh.
(Small aside: If one of these nucleic fricatives follows an ejective, the ejective marking moves to the right of all the consonants. So a word that begins with k' and then has a nucleus of fó is spelled and pronounced kf'ó.)
There are a number of rules for what happens when two vowels (with vowels including fricatives) come next to one another. The result is too complex to list out in text, so I'm afraid I have to do a table, and since Tumblr doesn't do tables, it has to be visual. Here it is:
So, green means the sequences of vowels are allowed to go together without anything changing. Yellow means the sequence is allowed, but some sort of phonological change occurs. Red means the sequence is disallowed. There is also a general prohibition against three of the same sound in a row, even if one is an onset and two are nuclei. Thus, while ss is licit, sss is forbidden. It is worth noting that several of these vowel-vowel sequences result in monophthongs. This is important for the phonology when it comes to tone assignment. The monophthong sequences are:
*aa > a
*ai > e
*ao/*au > o
*ou/*oo > u
This means that certain instances of the vowels [a], [o], and [u] are phonologically long, and the vowel [e] is also phonologically long (and also brings it up to a five vowel system!). Some other interesting notes:
Long high vowels broke, as in English (so *ii > ai and *uu > au).
The first element of opening diphthongs fortify into a fricative (so *iV sequences become shV and *uV/*oa sequences become fV/fa).
Any time s and sh come next to each other the result is ssh (i.e. [ʃʃ]).
The only consonant f can occur next to as a part of the nucleus is f.
Now, the tones are fairly simple. There are three tones:
High Tone [´]: The vowel is pronounced with high pitch—much the way a vowel is in English when it's stressed.
Low Tone [`]: The vowel is pronounced with low pitch—much the way a vowel is in English when it's unstressed (and also not in front of a stressed vowel).
Falling Tone [ˆ]: The pitch starts off high and falls before leaving the vowel—like when you see a kitty and go, "Awwwwwww!"
How tone is assigned is complex. Good news is if the nucleus is consonantal (just fricatives), there's no tone. Fricatives don't bear tone in Ts'íts'àsh.
The short story for tone is that tone in Ts'íts'àsh came from a combination of an older stress system and cues from onset and coda consonants. An older stressed syllable is called a blaze syllable, and an older unstressed syllable is called a smolder syllable. A smolder syllable will always have low tone unless it has a current or former coda voiceless stop. Then it will have high tone. A blaze syllable can have any tone, but the tone it's assigned depends on the surrounding consonants. Some rules:
If the blaze syllable is open, its tone will be high, unless it begins with a voiced consonant, in which case the tone will be low.
A syllable with one vowel that ends in a voiceless stop will have high tone.
Otherwise, a syllable with a voiced consonant onset will have low tone. The sole exception is a syllable beginning with a voiced consonant that has two vowels and a voiceless stop coda. That syllable will have low tone on the first vowel and high on the second (unless the VV sequence results in a monophthong, in which case the tone is high).
Sequences of two vowels generally have a high-low sequence. The same goes for phonologically long monophthongs.
Coda fricatives will drag tone down.
VV sequences in blaze syllables reduce to singletons in smolder syllables when syllable type shifts in a word (e.g. due to affixation).
And that's all there is to it! It might seem tough to pronounce some sequences we don't have in English, but once you let yourself go and lean into it, it's kind of fun! Jessie and I were both really pleased at how well it was carried off by the actors. They really did a great job!
Thanks for the ask!
#conlang#language#elemental#pixar#pixar elemental#elemental pixar#tsitsash#ts'its'ash#ts'íts'àsh#phonology#phonetics#sir-samuel-iii
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Raspberry Forethought Nucleus
I think I'm satisfied with a cover and title at last.
What's it about? An android ranger with unclear motives and a chip on xer shoulder arrives at the company-owned Viper Den Space Station, where the local reeve and her security team are bracing for an attack from a rising cargo-theft gang. New clashes with old as the neoteric android, an outdated security AI, the long-standing reeve, and her hotshot deputy must join forces against this outside threat--but as tensions flare and questions about each other's checkered pasts arise, it seems the real threat may come from within.
Is that...a genre? I bring to you tonight a brilliant deconstruction of literature and life itself...Okay, fuck it, I lied. It's a noir western in space. Whatcha gonna do
The plan: I've got it started. It's gonna be a novel. Then it might be a whole continuous series for all I know. It compels me.
Some fun facts:
The station has no artificial gravity.
The personal spacecrafts don't have guns or lasers. Instead, space fights are described as "knife fights" because they're done by bashing each other's ships around until someone wins.
What's with the title? The security system can do almost nothing without human permission. "Raspberry forethought nucleus" is the verbal code given in the first chapter that gives him permission to straight-up kill people :)
#WIP page#RFN WIP#hm easy tag I like it#will do moodboards and a PPT if there's interest#Big Iron synthwave version plays in the background as you read the summary
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Friday, October 18, 2024
Big Tech Goes Nuclear (1440) Amazon is investing $500M toward nuclear power to meet the rising energy demands of its data centers and artificial intelligence initiatives. Yesterday’s announcement comes two days after Google unveiled plans to purchase nuclear power and less than a month after Microsoft said it would reopen the Three Mile Island plant—home to the worst nuclear accident in US history—to fuel its AI efforts. Nuclear power accounts for 19% of US electricity generation and comes from energy released when the nucleus of a heavy atom splits into lighter atoms. While expensive and potentially hazardous, proponents pitch nuclear power as a clean alternative to greenhouse gas-emitting energy sources like coal, oil, and gas. Energy-intensive generative AI applications and data centers are expected to account for roughly 9% of total US power consumption by 2030.
Many schools are still closed weeks after Hurricane Helene. Teachers worry about long-term impact (AP) Tens of thousands of students in the Southeast are dealing with school disruptions after Hurricane Helene wreaked havoc so severe—on homes, campuses and municipal power and water systems—that some districts have no idea when they will reopen. While virtual learning helped during the COVID-19 school closures, that has not been an option for this crisis because internet and cellphone service has remained spotty since the storm struck in late September. In hard-hit western North Carolina, some districts warn students will miss up to a month of school, and others say they can’t yet determine a timeline for returning to classrooms. “I feel like a month is a lot, but it’s not something that can’t be overcome,” said Marissa Coleman, who has sent her four children to stay with grandparents in Texas because their home in North Carolina’s Buncombe County has no running water. “But if we get further into Thanksgiving and Christmas, it’s like, how are they actually going to make this up?”
Anguilla has turned the AI boom into a digital gold mine (AP) The artificial intelligence boom has benefited chatbot makers, computer scientists and Nvidia investors. It’s also providing an unusual windfall for Anguilla, a tiny island in the Caribbean. The British territory was allotted control of the .ai internet address in the 1990s. It was one of hundreds of obscure top-level domains assigned to individual countries and territories based on their names. While the domains are supposed to indicate a website has a link to a particular region or language, it’s not always a requirement. Google uses google.ai to showcase its artificial intelligence services while Elon Musk uses x.ai as the homepage for his Grok AI chatbot. Startups like AI search engine Perplexity have also snapped up .ai web addresses. Anguilla’s earnings from web domain registration fees quadrupled last year to $32 million, fueled by the surging interest in AI. The income now accounts for about 20% of Anguilla’s total government revenue.
Is Brazil’s Supreme Court Saving Democracy or Threatening It? (NYT) Daniel Silveira, a policeman turned far-right Brazilian congressman, was furious. He believed Brazil’s Supreme Court was persecuting conservatives and silencing them on social media, and he wanted to do something about it. So he sat on his couch and began recording. “How many times have I imagined you getting beat up on the street,” he said in a 19-minute diatribe against the court’s justices. He posted the video on YouTube in February 2021, adding, “I’ll say what I want on here.” A Brazilian Supreme Court justice immediately ordered his arrest. A year later, 10 of the court’s 11 justices convicted and sentenced him to nearly nine years in prison for threatening them. Jair Bolsonaro, Brazil’s president at the time, pardoned Mr. Silveira, but the Supreme Court overruled him. Today, Mr. Silveira remains in prison. There is no room for appeal past the Supreme Court. Mr. Silveira’s case is part of a creeping institutional crisis for Brazil. For the past five years, the nation’s Supreme Court has expanded its power to carry out a sweeping campaign to protect Brazilian institutions from attacks, many of them online. To the Brazilian left, the offensive has helped rescue Brazil’s democracy. To the right, it has made the court a threat to democracy itself.
France's Macron calls for an end to arms exports used in Gaza and Lebanon (Reuters) Israeli Prime Minister Benjamin Netanyahu and French President Emmanuel Macron are getting into a mud-slinging fight for all the world to see. Last week, Macron called for an arms embargo on Israel, saying that the country needed to find a political solution to its issues in Gaza and Lebanon. Netanyahu responded with an angry video posted on X, calling Macron (and others calling for an arms embargo on Israel) a “disgrace.” On Tuesday (this week), Macron reportedly made statements during a closed-door meeting with French ministers, saying that Netanyahu should not “ignore United Nations decisions” because “his country was created by a U.N. decision.” Israel has repeatedly called for the dismantling of UNRWA, the UN agency that provides aid for Palestinian refugees, and is looking to pass legislation barring the organization from operating in Israeli territory—a decision the UNRWA warns will essentially “disintegrate” its services in Gaza and the West Bank. Israeli soldiers have also targeted U.N. peacekeepers in Lebanon on multiple occasions since the IDF’s ground invasion of the country began earlier this month. Netanyahu clapped back at Macron soon after his statements, saying, “It was not the U.N. resolution that established the State of Israel, but rather the victory achieved in the War of Independence with the blood of heroic fighters, many of whom were Holocaust survivors—including from the Vichy regime in France.”
Zelenskyy outlines his ‘victory plan’ to Ukraine’s lawmakers (Politico) Yesterday, Ukrainian President Volodymyr Zelenskyy unveiled his grand “victory plan” to Ukraine’s parliament. It’s made up of five main points and three secret annexes—we’re not privy to the annexes, but here are the five main points: an invitation to join NATO, a larger and faster supply of Western weapons with no restrictions on their use, a non-nuclear strategic deterrence package, deals which would trade Ukraine’s energy resources for money up front, and the possibility of U.S. forces training with battle-hardened Ukrainian forces after the war. Kyiv’s Western allies have not met the plan with the enthusiasm Ukraine might have been expecting. Meanwhile, Russia is getting a new infusion of troops. According to a senior Ukrainian military intelligence official, Russia has gathered over 3,000 North Koreans to fight in Ukraine. Russia disputes this and it’s unconfirmed.
Monsoon flooding closes schools and offices in India’s southern IT hubs (AP) Schools, colleges and government offices were shut Wednesday in parts of southern India as heavy monsoon rains triggered severe flooding. The worst-hit cities included Chennai and Bengaluru, the country’s industrial and information technology hubs. Power cuts and flight cancellations caused disruption, and thousands of residents prepared for more downpours over the next 48 hours. The June-September monsoon season has receded in northern parts of the country. However, the northeast monsoon has brought heavy rains to coastal Andhra Pradesh, Tamil Nadu, Kerala, and southern Karnataka state. At least 33 people died last month in rains and floods.
For Working Women in India, Staying Safe Can Feel Like a Full-Time Job (WSJ) When Ajita Topo, a cook in an affluent neighborhood in Delhi, leaves work in the evening, she holds her bag like a shield against her chest, keeps her fists clenched and carries a black umbrella with a very sharp end to ward off a possible attack. She makes sure to wear lots of layers—no matter how hot it is—to deter someone from trying to grope her chest, and secures her bun with a sharp metal stick as an additional weapon. Topo isn’t being paranoid. Last year, she was followed by two men when she left work after 10 p.m. She managed to scare them away by shouting as she passed homes with guards outside. “Workplace, public transport, public places, we feel safe nowhere,” said Topo, the sole breadwinner for her two children. “The only solution is to stay alert at all times.” For many women in India, taking steps to ward off a violent attack—and reassuring their families they are safe while at work and on their commutes—is an invisible form of labor that is a central element of their work life. The killing and rape of a trainee doctor in the city of Kolkata in August was a fresh reminder for Indian women who work of the dangers lurking in public spaces where women are far less visible than men.
Where a Million Desperate People Are Finding Shelter in Lebanon (NYT) At dusk, the parking lot of Tripoli’s Quality Inn is packed with cars and families milling about. Children’s shouts fill the air, reminding some of better times, when the hotel hosted weddings and birthdays parties. Now, though, the cars in the lot are dusty and battered, the families sit on patches of grass, their faces worn with worry, and the children play in a drained swimming pool. That is because the Quality Inn has been transformed into one of the biggest shelters in Tripoli for displaced Lebanese fleeing Israeli bombing in the country’s south. In Lebanon, the displaced are practically everywhere. In Beirut, the capital, where many are staying, they have set up makeshift tents on the corniche by the sea, crafting shelters out of stray metal poles, bits of awnings and blankets. In the city’s parks and squares, some families have placed floor coverings on the ground, anchoring them with cases of water and folded blankets. Others are taking shelter anywhere that they can, mostly in schools but also in unfinished buildings. Of a population of around six million, including about two million Syrian refugees, just over one million people have been forced from their homes by the bombings, the United Nations and the Lebanese authorities say.
IDF says it killed top Hamas leader (Politico) The Israel Defense Force confirmed it has killed top Hamas leader Yahya Sinwar, the lead architect of the Oct. 7 attack and the No. 1 target of its yearlong campaign in Gaza. Details of Sinwar’s death remain sketchy, but he appears to have been killed in an operation in southern Gaza that was not specifically targeting him. It is unclear what effect, if any, Sinwar’s death will have on the future of Israel’s campaign in Gaza, let alone on the newly emerging front against Hezbollah in Lebanon.
Israeli attacks on aid convoys in Gaza persist, U.N. says (Washington Post) Israeli troops have opened fire on U.N. aid convoys to northern Gaza at least four times in three months, according to U.N. and other humanitarian officials, damaging the vehicles and narrowly missing staff members inside. On Sept. 9, the officials said, the Israeli army held a convoy involved in the United Nations’ polio response at gunpoint for 7½ hours, claiming that several people in the vehicles were wanted men. They were questioned and eventually allowed to proceed. “They basically surrounded our vehicles, pointing assault rifles at our cars, and they were shouting that we’re terrorists,” said one U.N. staffer. U.N. officials describe the Sept. 9 incident as emblematic of an environment of mistrust, in which Israeli soldiers, many of them reservists, command significant power at the checkpoints that humanitarian workers must cross to enter northern Gaza and face few consequences for their actions.
Why Big Pharma refuses to take on the threat of antibiotic-resistant germs (Die Zeit/Germany) Some 40 million people will die from antibiotic-resistant germs in the next 25 years, according to the latest estimate. All reasonable experts agree: New medicines must be developed urgently, otherwise we will face the threat of living in a post-antibiotic era, an era in which people die from simple infections because doctors can no longer treat them. Yet although the problem and solutions are obvious, there are very few new antibiotics in the research pipelines of the big pharmaceutical companies. More and more companies are even closing down their antibiotics divisions. The reason? Antibiotics are not profitable. Poor countries are not lucrative sales markets. Companies would rather focus on another cancer drug that marginally improves the prognosis for lung cancer; another cholesterol-lowering drug that is slightly more effective than its predecessor and is so inexpensive to develop that it brings in billions without any major risks; or yet another anticoagulant. And so billions of dollars in development costs are spent on drugs that have little impact on people’s health, while virtually nothing is spent on developing drugs that could save millions of lives.
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The TESCREAL acronym is bad because it puts excessive focus on fairly unimportant aesthetic and occultish curiosities and ignores the actual ideological baggage of the vague movement it identifies. The vague movement does exist and is probably worth naming but I think Rationalism worked just fine despite the ambiguity. The various apocalyptic prophecies and cosmologies and rituals and vocabulary quirks are easy to sneer at but they don't really tell you what the ideology is or if it's bad.
The reason they name Transhumanism and Extropianism and Singularitarianism is pretty obvious, it's a geneaology of Yuddism. And Yud is certainly worth discussing, both because of his role as a nucleus for the movement and because he was somehow let into Time Magazine to call for unilateral air strikes on datacenters and such. But if you want to say Yuddism you could probably just say that. Bringing Cosmism into it seems especially strange, sure it developed some ideas that rhyme but then so did Mormonism. Suspect that one's there just for the russophobia, honestly.
Rationalism and Effective Altruism are the main brands under which the subculture can be found. From what I can tell the overlap between these groups is massive (I would guess it's roughly similar to the overlap you would find between, say, the Catholic Church and a Catholic charity) so it makes sense to consider them together. I've seen the connection denied, which I suspect to be merely a manifestation of the standard Rationalist escape from terms (post-rat, post-post-rat, rat-adj, tpot, etc). It doesn't really matter though, if the overlap exists then you can just say Rationalism, and if it doesn't there's no point to a term. Longtermism is just a branch/faction of Effective Altruism that skips the Altruism part.
If you really wanted to create a novel term then I think the best place to start would be with the actual intellectual influences of the movement. The main beliefs that repeatedly crop up throughout Rationalist thought can broadly be characterized as Positivism, Utilitarianism, Neoliberal and Austrian Economics, and Sociobiology. This is combined with great interest in and optimism for technology, especially "AI" but also various forms of biotechnology. The reason these ideas tend to be popular among Rationalists is that they promise quantitative explanations and possibly exploitations of complex phenomena dense with qualitative evaluations.
Rationalists also have unusual epistemic commitments, strong group identity, and jargon, well beyond what is typical of fandoms and ideologies, their closest peers as collectives. This makes them somewhat vulnerable to cult formation. In my opinion it also explains some of the strange behavior of certain ex-rationalists (including Emile Torres by the way). It can also make them rather frustrating to argue with on occasion.
#honestly I'm not sure why Rationalists aren't more into Cliodynamics#my take on Rationalism is that it's basically Libertarian Trotskyist TVTropes
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16^12, a nucleus of worldview (6/?)
Continuation upon this loose thread.
I got a new dream onto the intertextual implications, history doctorate-tier narrative components & overall intrigue of my books' narrative. And it boils down to something somewhat similar to Tolkien's works as a nuanced, mysterious, profound but yet optimistic, empowering & introspective complete cosmic-scale GLOSS* history epic about the cycle of life versus entropy, coming-of-age, constructing meaning in bleak times & about all sorts of """autistic""" patterns.
What that means is that I have a clearer perspective & direction of what plot points could be around the core series of books and how to reuse what other good things come from what I shall write soon. And while still taking into account some key world building parameters to keep this narrative realm timeless-ly useful, I now know what overall intrigue for the core duo of characters (aka "Kate" the human INTJ historian lady & "Valenz" the ENFP synthetic-tier android social assistant + syndicalist vigilante) is gonna feel like (a escalation of power, of worldly understanding & of individual self-control);
And while they still have to overcome systemic issues & bring forth constructive change, I think adding this very spiritually metaphysical, honest nuanced yet hopeful, constructive & affirmative aspect will really enrich the paracosm long-term appeal & the intertextual relations derived from such, especially considering all the historical & mythological heritage that I am tying it with (such as the Bronze Age period, World War 1, Thirty Years War, Abrahamic Mythos...) going both backwards, forwards and sideways in time.
Granted, I do have some personal worldview values to transmit, some opinionated tools to use & so much additional research & iterative work left to be done in order to reach the one planet cyclic universal history scope thing I am onto, but rest assured I will find S.M.A.R.T ways to distribute the risks & rewards of this endeavor into edible chunks of data as well as leave a decent share of open space / mystery to do as you please (within ethical consensus bounds) inside that paracosm framework of ours.
Very abstract, ain't it? Well, I will pace more specific explanations for it out in due time as I figure things out as the open book I really am inside. Farewell to soon!
#maskutchew#16^12#worldbuilding#actually autistic#red instead#far far away cosmic future at the edge of time#bronze age solarpunk as time period mood?#epic track record of a open source abstract syntax tree of Lisp meta-patterns...
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Source: Animation By Adam Ferriss
Silicon Valley Wants To Help Me Make A Superbaby. Should I Let It?
High-Powered Couples Are Turning To Genetic-Testing Startups To Help “Design” Their Offspring. I Decided To Take The First Steps Myself.
— By Margaux MacColl | June 01, 2025
Most people haven’t met a superbaby. I have.
Last year, I attended a cocktail hour at a venture capitalist’s Presidio mansion, filled with founders from his firm’s portfolio companies. As the entrepreneurs lounged on couches, sipping craft cocktails and pitching their wealth management software and AI security systems, conversation suddenly sputtered. The investor’s wife, a startup founder herself, descended the grand white staircase, cradling the night’s real headliner.
“Here’s My SuperrrrrBabyyy,” the investor cooed, taking the cherubic newborn from his wife’s arms.
The couple had told me weeks earlier that they had given birth to the superbaby using in vitro fertilization and a surrogate. They had screened their embryos with Orchid, a genetic testing startup that charges upward of $2,500 per embryo to test for polygenic conditions — complex diseases caused by the combined effect of many genes, like bipolar disorder or Alzheimer’s. Though the superbaby drooled and babbled like a regular infant, he was as genetically optimized as current science will allow.
Polygenic testing startups are Silicon Valley at its most audacious: promising to make future generations healthier and smarter, while inviting deep controversy over the soundness of the science and its potential for harm. Studies have shown that assigning “risk scores” for polygenic diseases is still a crapshoot, the results “random” and “inconsistent,” while critics claim they over-rely on data from people of European descent and offer parents a dangerous illusion of control. Hank Greely, a bioethics and law professor at Stanford University who taught Orchid founder Noor Siddiqui, said polygenic risk scores are “unproven, unprovable, unclear,” and that couples who have used them to select embryos have “wasted money.” He told me his former student Siddiqui was “very smart” but had likely “gotten ahead of her skis.”


In spite of widespread doubts among scientists, over the last five years, tech heavyweights like Anne Wojcicki, Sam Altman, Vitalik Buterin, Elad Gil, and Alexis Ohanian have poured millions into the direct-to-consumer polygenic testing startups Orchid, Nucleus, and Genomic Prediction. It’s a bet on a radical future, one in which, for a few thousand bucks, a biotech company can screen your embryos, comb through your DNA, and assign you and your future child odds on everything from developing a drug addiction to becoming obese. Some even estimate your unborn’s IQ.
Unlike most genetic tests, which screen for single-gene diseases like Tay-Sachs or cystic fibrosis, Orchid — which has rapidly become the go-to testing service for Silicon Valley elites — scans embryos for polygenic diseases like type 2 diabetes and inflammatory bowel disease. Orchid sends parents an online report that estimates the genetic risk of each embryo developing these illnesses.
Parents are left to decide: Which risks can we live with? Which embryos are worth implanting? And which tests are accurate?
Given the celebrities who have vocally lined up behind these services, it’s easy to be skeptical. Elon Musk reportedly used Orchid for at least one of his children. Michael Phelps and longevity extremist Bryan Johnson have both endorsed Nucleus. “Orchid is a categorical change,” Coinbase CEO Brian Armstrong, an investor, said in a quote on the company’s website. “It’s a step towards where we need to go in medicine — away from managing chronic disease, and towards anticipating and preventing it.”
In the weeks and months after the VC’s house party, I couldn’t stop thinking about their gene-curated superbaby. How many parents in San Francisco would happily experiment with the genetic disposition of their future children? Would these people be willing to hand-select “healthy” embryos even if there wasn’t any regulatory oversight of genetic testing services? And what if the tests weren’t even accurate?
Then, in March, I learned that the genome sequencing startup Nucleus was launching a feature for couples planning to have kids. I reached out to Kian Sadeghi, the 25-year-old founder of Nucleus, who agreed to waive the $798 fee so The Standard could try their initial service, testing individual’s DNA for polygenetic risk. (I later learned that the polygenic family-planning service wasn’t test-ready yet.)
I proposed the plan to my husband: In the name of journalism and science, let’s hand over our DNA to an untested startup and see what Silicon Valley can tell us about our someday children. He reluctantly agreed.

‘A Total Black Box’
To understand the murky, revolutionary, and unregulated state of genetic research in the U.S., you have to start in 2003, when the Human Genome Project finished most of its mapping.
Before that, genetic testing was mostly used to search for a single gene mutation known to cause specific diseases (also known as monogenic diseases), like the mutated gene that causes Huntington’s. But with the project’s map of the human genome combined with new sequencing technologies, scientists could conduct massive studies that analyze the DNA of millions of people.
Around 2007, scientists started combing through databases of DNA to identify variants — differences in a DNA sequence — that kept showing up in people with illnesses like schizophrenia and coronary artery disease. Based on how many of these variants a person had, the scientists could assign them a “polygenic risk score” that estimated the genetic risk for the disease.
Since then, scientists have created thousands of polygenic risk scores for other diseases, including type 2 diabetes, breast cancer, and bipolar disorder. A 2018 study found that, in some cases, these scores were nearly as effective at predicting disease as monogenic testing. A high polygenic risk score doesn’t mean you’ll certainly get that disease — environment and lifestyle play major roles — but it does mean that your DNA may put you at higher risk.
‘It Is Not Always Transparent How Companies Are Calculating These Scores. They Claim To Have A Proprietary Algorithm, Which, In Reality, Is A Total Black Box.’
Yet the scores remain extremely controversial. Some scientists argue that it will take years before we know with certainty whether these scores can predict disease across a lifetime. One 2023 study from University College London researchers looked at more than 900 polygenic risk scores and found that the tests correctly identified only about 11% of the people who would develop the diseases.
“It is not always transparent how companies are calculating these scores. They claim to have a proprietary algorithm, which, in reality, is a total black box,” Jacob Sherkow, a law professor at the University of Illinois Urbana-Champaign who specializes in bioethics, told the university publication. “If they are not completely accurate, consumers may make adverse health choices on the basis of misinformation.”
Because of the scientific uncertainty, most doctors choose not to test patients’ DNA for polygenic risk scores. But that hasn’t stopped venture-backed startups from putting these scores directly into the hands of consumers. Orchid publicly launched its embryo testing service in late 2023, while Nucleus began whole-genome analysis in 2024. As Nucleus founder Sadeghi told me, doctors have historically treated the patient “like a baby” when it came to extensive genetic testing; these startups would entrust people with their own genetic information.
Despite my own worries about society sliding down a slippery slope to eugenicism, I I was still open to the possibilities of genetic testing. My husband and I are both 27, and our plan has always been to have kids at 30. If we wanted to take the first step toward birthing our own superbaby, we needed to start soon.
My husband, Connor, is a devout Catholic with a beautiful tendency to see every decision through a capital-M moral lens. For him, the idea of using Orchid to determine our baby’s genetics was a severe moral hazard. “This seems like a path toward having no people with Down syndrome, having no people with certain disabilities, even though there are people that have those disabilities that live fulfilling lives,” he said. “You’re talking about culling a tree of human evolution, right?”

However, there are some genetic realities that Connor and I must face. For one, his mother has multiple sclerosis, a debilitating disorder caused by a complicated combination of genetics and environmental factors. Meanwhile, my family has its Irish American streak of alcoholism, and my grandmother suffered from schizophrenia.
Though he wasn’t wild about submitting his DNA to Nucleus, Connor finally acquiesced just in time for the testing kit to arrive. The process was simple: We filled out a brief survey on our families’ medical histories, then swabbed the inside of our cheeks. We put our DNA samples into the vials and sent them off to a lab that would sequence our genomes.
After the lab processed our DNA, Nucleus would take the data and run it through its algorithms, searching our genetic codes for variants linked to diseases to determine our polygenic risk scores. This is only a fraction of what the company does: it also tests for monogenic conditions, and particularly high-impact variants, as well as incorporating factors like lifestyle and family history into their risk scores.
Six weeks later, an email from Nucleus arrived: Our results were ready. Sitting in my living room, I hovered my computer mouse over the link. It was like opening a Pandora’s box of ancestral curses. Connor’s mom feared that his results would announce, in flashing red text, that he had inherited her MS.
I was most afraid of what would happen next: If we both scored high-risk for something, what would we decide to do about it when I was ready to get pregnant?

‘Simulate Your Children’
What I did not expect was for my DNA results to look like a Spotify Wrapped. On a yellow background with white text, a Canva-esque slideshow informed me that my risk of type 2 diabetes is a whopping 53.8% — three times the average. I also have an above-average likelihood of developing celiac disease, coronary artery disease, and obsessive-compulsive disorder. I immediately envisioned my flailing future self: diabetic, gluten-free, clutching my chest mid heart attack.
Meanwhile, the test ruled that Connor also had a higher-than-average risk of coronary artery disease and OCD. “At least we’ll have heart attacks together,” he shrugged.
Then, relief: He doesn’t carry the variants most associated with MS. Years of buzzing, restless anxiety briefly stilled.
Nucleus plans to roll out a “genetics-syncing” service for couples that will allow it to “simulate your children” by weighing both parents’ risk scores and predicting what it means for offspring. But that feature isn’t available yet, so I turned to Orchid for a similar test. I emailed Siddiqui, the company’s founder, and asked if she could look over our DNA and tell me something — anything — about what life might have in store for our kids.
She agreed, so I downloaded the raw, unanalyzed genetic data from Nucleus (134 gigabytes) and sent them to Orchid. A few days later, I got an email that our results were ready.
Orchid offers every customer the chance to meet with a genetic counselor, who jumps on a Zoom call with couples as they open their results. (The company did this process for The Standard for free; normally, the pre-IVF family planning feature costs $995.) As I peered at the report with Orchid’s lead genetic counselor, Maria Katz, looking on, I gasped.
“I just don’t understand,” I said. “To me, this feels shocking.”
Both Nucleus and Orchid use proprietary models to assign their risk scores — and Nucleus incorporates more factors into their scores — so I expected the results to be slightly different. But unlike Nucleus’ report, Orchid’s claimed that, based on my genetics, I had a below-average shot at developing type 2 diabetes (23%, versus Nucleus’ claim of 53.8%). And, while Nucleus gave me a 8.6% risk score for breast cancer, Orchid insisted my risk score was over three times higher. Several scores for my husband were dramatically different, too: Nucleus told him he had a 65.6% risk of coronary artery disease; Orchid said 26%.
‘I Can’t Believe Silicon Valley Is Allowed To Do Shit Like This. I Mean, I Can Believe It. But Come On.’
Katz assured me that my confusion (cascading into anger) was “very fair.” But before we dove into the difference in scores, she wanted to show me Connor and my simulated embryo report. Still sharing her screen, Katz opened the Orchid patient portal and moused over to 12 line graphs, one for each polygenic risk score.
Our genes, when simulated together, were, in a word, grim. Our hypothetical child was expected to have a genetic risk of Class III obesity of anywhere from 11% to 25%, compared with the average of 9.2%. If we have a daughter, her inherited genes will give her a 14% to 28% chance of breast cancer. The average is 13%. And I haven’t done our child any favors in the schizophrenia department: The average risk score is 0.9%, but our child would likely have a score from 1% to 2.2%.
In fact, there are only three illnesses that our future kid would likely have a lower-than-average genetic chance of developing: celiac disease, type 1 diabetes, and type 2 diabetes.

The author's individual test results from Nucleus
When I was growing up, my father admitted to being afraid that my sister and I would abruptly untether from reality, unwitting victims of his genetics. This is what happened to his mother, who suffered from schizophrenia. But with the promise of this new technology, I could pick an embryo with the smallest chance of developing this damaging disorder. I imagined the peace of mind that comes from holding your own superbaby, knowing you did everything in your power to protect it.
But my reverie lasted only a moment, because the results I received from Nucleus and Orchid were so different. What was the point of these scores if they varied so much from company to company? What if the investor and his wife from that Presidio cocktail party had used Nucleus instead of Orchid to select their embryo? Would they have ended up with a completely different superbaby?
“I can’t believe Silicon Valley is allowed to do shit like this,” my husband said when I showed him the divergent scores. “I mean, I can believe it. But come on.”

The author's individual test results from Orchid
‘A Silicon Valley Guinea Pig’
I spent the next few days on the phone with Nucleus and Orchid trying to answer a simple question: Which company should I believe?
Katz, the counselor at Orchid, pointed out that, for many of the medical conditions, the company tested for significantly more variants. For type 2 diabetes, Orchid tested for more than 1.1 million variants; Nucleus, just 171,249. “I would say that I’m not sure if [Nucleus is] providing meaningful scores,” she said.
But the number of variants alone doesn’t guarantee accuracy. Jerry Lanchbury, a geneticist who has advised both Orchid and Nucleus, told me that in most polygenic models, the first fistful of variants are weighted significantly more than the rest, meaning that testing more than a million variants may not meaningfully improve predictions.
Even if the companies technically tested the same number of variants, they might have totally different datasets. Gabriel Lazaro-Munoz, a neuroscientist and bioethicist who conducts research on the societal impact of genomics, said that these datasets can skew towards certain races, or vary in size of samples — dramatically impacting an individual’s results from company to company.

The green bars show the estimated risk for the author and her husband's simulated children, via Orchid. Source: Margaux MacColl
Then I got on the phone with Nucleus founder Sadeghi. He was unbothered by the discrepancies in my results. He pointed out that, unlike Orchid, his company’s algorithm incorporates our family histories and lifestyles, expanding the polygenic risk score to an overall health score. My gender or body mass index could have raised my score. My husband is a former smoker, which could have increased his risk of coronary artery disease. “From what I can discover so far, they’re very explainable, right?” he reassured me.
But a week later, I got an email from Nucleus. My type 2 diabetes risk score had been adjusted, plummeting from more than 53% to 10.9%. My old score was derived from a 2018 study, the email informed me; the new one was based on a 2022 study and included 1.3 million variants — similar to what Orchid had used. My husband also got an email, saying Nucleus had lowered his risk of coronary artery disease.
The message assured us that our old scores “weren’t wrong,” but that “genetic science is always improving.”
Halle Marchese, Nucleus’s director of marketing, said in a statement that this was a planned update and that “the data we used to build the score improved and, hence, so did our analysis.”
But the timing was so convenient, I couldn’t help but wonder: if I hadn’t been a reporter cross-checking results across multiple services, would I still be working off a supposedly outdated score, going through life thinking I had a sky-high chance at type 2 diabetes? If I were a patient selecting an embryo based on a number derived from the 2018 study, there’d be no rewind button.
The main reason this behavior is allowed is that, when it comes to genetic testing, the U.S. is still the Wild West. While the U.K. and other countries have largely banned the use of polygenic risk scores in embryo selection, the Food and Drug Administration, the U.S.’s main medical enforcer, has largely chosen not to regulate companies that provide these services. This, despite the agency’s “mounting concern” that the services are misleading consumers, according to the National Human Genome Research Institute.
In late 2023, the FDA approved AvertD, a polygenic testing service that measures the risk of opioid addiction. But, for now, no other polygenic testing company is subject to FDA oversight. This means that every user, and every resulting superbaby, is a Silicon Valley guinea pig.

“This Is Not 100% Pseudoscience”
After having our DNA analyzed twice, and seeing the wild variances in the results from different companies, my husband and I have reached a new agreement: When it comes time to grow our family, we won’t be having a superbaby.
At least not until the FDA begins to regulate the companies providing these opaque, inconsistent, and often unreliable services. For Connor, the process was morally validating. “The scores give the illusion of control,” he shrugged. “I’m just pissed that now two startups have all my genetic data.”
But I felt like I’d lost something. Because I’ve now met children born through this process, I wanted to believe in it — to think there’s something I could do to spare our future kids from MS or schizophrenia. I liked this particular illusion of control.
“What gets me the most is that this is not 100% pseudoscience,” I told Connor. “It is coming from picking up patterns in DNA. The patterns might not ultimately mean anything, but the patterns are there.”
Imagine, 10 years from now, when there’s more research and consensus around which scores are accurate. “And all the rich people have healthier, non-schizophrenic kids,” I said. “That’s not fair.”
He kissed me. “It’s not fair,” he said. “But I don’t really want to play god anyway.”
I sighed. “But I kinda do.”
#Business#Culture#Silicon Valley#Tech#Superbaby#Genetic-Testing#Genetic-Testing | Startups | Help | “Design” | Offspring#Margaux MacColl#“Here’s My SuperrrrrBabyyy”#The San Francisco Standard#SFStandard.Com
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The heaviest proton emitter: A new type of atomic nucleus discovered
For the first time in more than thirty years, the heaviest nucleus decaying via proton emission has been measured. The previous similar breakthrough was achieved in 1996.
The radioactive decay of atomic nuclei has been one of the keystones of nuclear physics since the beginning of nuclear research. Now the heaviest nucleus decaying via proton emission has been measured in the Accelerator Laboratory of the University of Jyväskylä, Finland.
“Proton emission is a rare form of radioactive decay, in which the nucleus emits a proton to take a step towards stability,” says Doctoral Researcher Henna Kokkonen from the University of Jyväskylä.
Studying exotic nuclei is difficult, but not impossible
The new nucleus is so far the lightest known isotope of astatine, 188At, consisting of 85 protons and 103 neutrons. Exotic nuclei of this kind are extremely challenging to study due to their short lifetimes and low production cross sections, so precise techniques are needed.
“The nucleus was produced in a fusion-evaporation reaction by irradiating natural silver target with 84Sr ion beam,” says Academy Research Fellow Kalle Auranen from the University of Jyväskylä. “The new isotope was identified using the detector setup of the RITU recoil separator.”
Study reveals new findings on heavy nuclei
In addition to the experimental results, the study expanded a theoretical model to interpret the measured data. Through the model, the nucleus can be interpreted as strongly prolate, i.e. “watermelon shaped”.
“The properties of the nucleus suggests a trend change in the binding energy of the valence proton,” says Kokkonen. “This is possibly explained by an interaction unprecedented in heavy nuclei.”
The study is a follow-up to the master’s thesis
The study is part of Kokkonen’s doctoral thesis and a direct scientific follow-up to her master’s thesis, in which she discovered a new type of atomic nucleus, the 190-astatatine. The thesis article was published in the Physical Review C journal in 2023.
“Isotope discoveries are rare worldwide, and this is the second time I have had the opportunity to be part of making history,” Kokkonen rejoices. “Every experiment is challenging, and it feels great to do research that improves understanding of the limits of matter and the structure of atomic nuclei.” The research article was written as part of an international research collaboration involving experts in theoretical nuclear physics.
IMAGE: An AI-generated illustration of a proton emission. A proton is ejected from an astatine nucleus.
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The Rise of AI Jobs and Opportunities in Kochi’s IT Ecosystem
Kochi, known for its strategic position as a coastal hub and gateway to Kerala’s digital ambitions, is quickly emerging as a nucleus for tech-driven innovation. As the city nurtures a growing IT ecosystem, Artificial Intelligence (AI) is becoming a central pillar of transformation. Startups, IT firms, and government-backed initiatives are increasingly embracing AI, creating a wave of new career opportunities across sectors.
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Pulsar App Review – Turn Any Link Into SEO Traffic Magnet Just In 60 Seconds
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Check Out My Previous Reviews: Clonezy AI Review, CloneWeb AI Review, Creative Lab AI Review, QuizzAI Review, and VidioGenie AI Review.
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