#Oral Submucous Fibrosis

[burningcatcrusade]

Uncovering Hidden Dangers: Side Effects of Chewing Gutkha

Gutkha is one of the most popular chewing tobacco mixture consumed mostly by South Asians, and primarily by Indians in the entire region. Known to give a high that lasts a fair while, its side effects are felt far into the future. Presented as a fine blend of betel nut, tobacco and a variety of added flavours, it is one of the main causes of a lot of grief to not just patients but also their family members, since most of the gutkha consumers come from middle class, lower middle class, and poor families. This is one of the great many disadvantages of chewing gutkha.

According to the World Health Organisation (WHO), “Gutkha is one of the major causes of death and disease in India and accounts for nearly 1.35  million deaths every year. Nearly 267 million adults (15 years and above) in India (29% of all adults) are users of tobacco” (i).

SIDE EFFECTS OF CHEWING GUTKHA

Poor Oral Health - The caustic ingredients in gutkha are like locusts to crop. From mild to advanced symptoms likes mouth ulcer, burning sensation during eating food , gum diseases,coupled with restricted mouth opening Oral Submucous Fibrosis learn more visit www.osmfmouthopeningkit.com and oral cancer are what doctors treat the most.

Mouth Cancer - The carcinogenic compounds are the chief reasons for the removal of tongues, parts of vocal chords, and parts of jaws in many middle class and poor families since most of these consumers live in rural areas according to NCBI (ii). These are directly the result of oral, throat, and oesophageal cancers.

DEAL WITH THE GUTKHA EPIDEMIC

Even though oral cancer cases are going up as the nation-wide ban (iii) on gutkha remains unimplemented, renowned medical practitioner Dr. Bharat Agravatwww.drbharat.agravat.com, Dr Kartavya Agravat and his team have developed a powerful solution that deals with the chewing habit of gutkha — the QSG Kit. Developed Triple Acting Formulation using Medicated Gums ingredients working in tandem with cutting-edge technology and Ayurvedic herbal practices, this kit has been producing stunning results. The QSG Nico Gums, QSG Energy Burst Lozenges and QSG Sleep Gummies have helped thousands quit the dire habit of chewing gutkha leading to healthier lifestyles. Try it today by visiting our websitewww.quitsmokinggutkha.comand be assured, you'll get the same results.

SOURCES:-

(i) https://www.who.int/india/health-topics/tobacco

(ii) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312563/

(iii) https://timesofindia.indiatimes.com/city/pune/oral-cancer-cases-up-as-gutka-ban-remains-on-paper-docs/articleshow/107395357.cms

[ficket027]

OSMF Vita Tab: The Best Antioxidants with Multivitaminto Heal OSMF and Prevent Oral Cancer

OSMF Vita Tablet is a powerful Antioxidants, MultiVitamin and Minerals nutrition supplements manufactured by Dr. Agravat Healthcare Ltd. It contains like Lycopene with Antioxidants, Minerals and MultiVitamin A, E, C, B2, B1, B12. etc. Since Lycopene isn't produced by the body naturally, hence it happens to be the main weapon in the fight against OSMF. OSMF Vita Tab also contains other Multivitamins and minerals infusing their strong anti-inflammatory and anti-oxidant properties that help patients heal quicker and nip OSMF in the bud. It is also used in the critical Lichen Planus treatment and is used to promote heart and bone health. To use OSMF Vita Tab, patients just need to take one tablet everyday with water after breakfast or as advised by the attending physician. The tablet has no side-effects as it is a nutrition supplements product, GMO-free product that is also backed by the clinically proven and CE certified. It is also part of the famous OSMF Mouth Opening Kit that has been a stunning revelation in tackling and uprooting OSMF. To purchase OSMF Vita Tablet, or the kit itself, please visit the OSMF Mouth Opening Kit. Shop on www.agravat.com    or https://osmfmouthopeningkit.com online webstore.

[omdentalchandlodiya]

Oral Submucous Fibrosis Treatment in Chandlodia

For effective Oral Submucous Fibrosis treatment in Chandlodia, visit Om Dental, Face & Oral Surgery Clinic. Led by Dr. Ankit Patel, the clinic provides specialized care for this condition, utilizing the latest techniques and personalized treatment plans. With a focus on patient comfort and recovery, Om Dental ensures comprehensive care in a modern, welcoming environment. Trust Dr. Patel and his team for the best treatment outcomes for Oral Submucous Fibrosis.

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Red And White Lesions of Oral Cavity Notes

[aarnablaine10]

Aloe is used topically (applied to the skin) and orally. Topical use of aloe is promoted for acne, lichen planus (a very itchy rash on the skin or in the mouth), oral submucous fibrosis, burning mouth syndrome, burns, and radiation-induced skin toxicity.

https://cutt.ly/s4PedJp

[marcletherapy]

Health Benefits Of Turmeric And Curcumin

Marcel is #1 India’s leading manufacturer, suppliers of health benefits of turmeric and curcumin in Ahmedabad, Gujarat, India. Get In Touch With Us Now!

[lupine-publishers-ipdoaj]

Potentially Malignant Disorders and Pediatric Dentistry : Review

Introduction

Precancerous lesions of oral mucosa, known as potentially malignant disorders in recent years, are consists of a group of diseases, which should be diagnosed in the early stage. Oral leukoplakia, oral submucous fibrosis, and oral erythroplakia are the most common oral mucosal diseases that have a very high malignant transformation rate.

Read More About This Article Please Click on Below Link: https://lupinepublishers.com/pediatric-dentistry-journal/fulltext/potentially-malignant-disorders-and-pediatric-dentistry-review.ID.000235.php

Read More About Lupine Publishers Google Scholar Articles: https://scholar.google.com/citations?view_op=view_citation&hl=en&user=h1QvhsYAAAAJ&citation_for_view=h1QvhsYAAAAJ:YFjsv_pBGBYC

[urduhindipoetry]

SMF CARE Lycopene Softgel Capsules with Antioxidants, Vitamins and Minerals

SMF CARE Lycopene Softgel Capsules with Antioxidants, Vitamins and Minerals

Price: (as of – Details) This specially formulated nutritional supplement contains antioxidants, vitamins and minerals. It helps people suffering from Oral-submucous Fibrosis (SMF). Moreover, it heals oral ulcers quickly and opens stiff mouth caused by tobacco. SMF Care capsules have NO SIDE EFFECTS on long term use! Since this is a nutritional supplement, it boosts our immunity and can be taken…

[osmfmouthopeningkitmedicine]

OSMF Restricted Mouth Opening Treatment at Home Kit

Natural Treatment for Oral Submucous Fibrosis Mouth Opening at Home Kit

Easy to use specially formulated for Mouth Opening treatment due to oral sub mucus fibrosis, Medicine, and exercise device at home. This kit is unique in its type useful in restricted mouth opening, causes due to chewing of Pan Masala, Sopari, Tobacco, Gutkha, Khaini, and Smoking.

Buy Online now  https://www.drbharat.agravat.com/osmf-mouth-opening-treatment-at-home-kit

#mouthopeniningtreatment

#osmf

[innspubnet]

Review Paper on Systemic Health Effects of Areca Nuts | IJB Journals

Review Paper on Systemic Health Effects of Areca Nuts | IJB Journals

Mrs. Maryam Khan and Saba Shamim from the institutes of The Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Defence Road Campus, Lahore, Pakistan, wrote a review paper entitled “Systemic Health Effects of Areca Nuts with Particular Emphasis on Carcinogenesis – A Review.” This review work was published by The International Journal of Biosciences | IJB under…

[lgenaglassgg-blog]

USA Clients highly recommend Best Product for Mouth Opening Treatment Video Review at Home Kit due to OSMF

USA Clients highly recommend Best Product for Mouth Opening Treatment Video Review at Home Kit due to OSMF

USA International Clients highly recommend Best Product Honest Video Review & Testimonial of Popular Restricted Mouth Opening Treatment at Home due to OSMF.

This kit is unique in its type containing medicine and mouth opening exercise device Easy-To-Use in restricted mouth opening due to Chewing of Pan Masala, Supari betel nuts (Areca catechu), Tobacco, Gutkha, Khaini, Smoking, Nutritional deficiencies, ingestion of chilies, and immunologic processes may also have a role in the development of oral submucous fibrosis.

Kit Contains 2 months medicines and….

* Free Consultation with more than 20 years of an experienced dentist in OSMF surgical treatment. (One Time)

* Two Types of OSMF medicine.

* 2 bottle OSMF Mouth Rinse

* Easy Mouth Opening Device for Physiotherapeutic Exercise

* Mouth opening measurement scale

Buy/Shop Online now: https://www.drbharat.agravat.com/osmf-mouth-opening-treatment-at-home-kit

#mouth opening device

[fortheloveofnutrition]

It's Summer time! Which means many of us get to have fun in the sun for much needed Vitamin D; which we know helps regulate our immune systems and the absorption of calcium & phosphorus.

Unfortunately, for many of us, fun in the sun also equals sunburns. And what's the first thing we think of when treating a sunburn? Aloe Vera!

Besides being the fragrant green gel in a bottle you buy at the drug store, Aloe Vera is a succulent plant that grows in hot, dry climates and has been used for multiple medicinal benefits for centuries, as we find evidence of its use in Ancient Egypt.

Although aloe is 99 percent water, aloe gel also contains substances known as glycoproteins and polysaccharides. Glycoproteins speed the healing process by stopping pain and inflammation while polysaccharides stimulate skin growth and repair. These substances may also stimulate the immune system.

Most often, Aloe is used topically (applied to the skin). Topical use of aloe is promoted for acne, lichen planus (a very itchy rash on the skin or in the mouth), oral submucous fibrosis, burning mouth syndrome, burns, and radiation-induced skin toxicity.

But did you know you can ingest aloe Vera juice to benefit digestion, immune support, and the extract has benefits for your oral health too?

You can add aloe vera juice to foods like smoothies, cocktails, and juice blends. The juice is a widely known health product with numerous benefits including blood sugar regulation, improved digestion, constipation relief, promote weight loss, diabetes, hepatitis, and inflammatory bowel disease (a group of conditions caused by gut inflammation that includes Crohn’s disease and ulcerative colitis).

The Juice may contain gel, or pulp, the latex (the layer between gel and skin), and green leaf parts. These are all liquefied together in juice form. Some juices are only made from gel, while others filter the leaf and latex out. It's good to note that the latex has a laxative effect.

In a 2014 study published in the Ethiopian Journal of Health Sciences, researchers found aloe vera extract to be a safe and effective alternative to chemical-based mouthwashes. The plant’s natural ingredients, which include a healthy dose of vitamin C, can block plaque. It can also provide relief if you have bleeding or swollen gums.

Best part is, you can grow your own little aloe plant and use the gel from inside the leaves right at home.

How has aloe helped you? Happy summering!

[marcletherapy]

Mouth Opening Treatment

Marcel is the best service of Health Benefits of mouth opening treatment in Ahmedabad, Gujarat, India. For More Information Contact Us Now!

[mouthopeningkit1]

पान मसाला गुटखा सोपारी खाने से बंद मुंह खोलने का दवा एक्सरसाइज घर बैठे। OSMF माउथ ओपनिंग किट Teaser

ऑनलाइन ख़रीदे https://www.osmfmouthopeningkit.com

पान-मसाला गुटखा और सोपारी खाने से बंद हुआ मुंह खोलने का इलाज घर बैठे । ये दवा और एक्सरसाइज करने से

मुंह खुलता है । ओएसएमएफ माउथ ओपनिंग किट

यह अद्वितीय किट में आपको मिलेंगे ४ प्रोडक्ट्स

1. OSMF POPS™ - मुंह के फाइब्रोसिस लक्षणों में कारगर विश्वकी की पहली ओरल अब्सॉप्शर्न के लिए इनोवेिटव

और पेटेंटेड हबर्ल ओरगेनिक लॉलीपॉप।

2. UNIQUE MOUTH OPENER™ - ओरल सब म्यूकस फाइब्रोसिस की ट्रीटमेन्ट में माउथ ओपिनं ग के

िलए असरकारक और पेटेंटेड, अनोखा, गाइडडे िफिजयो-थेरप्यूिटक एक्ससरसाइज िडवाइस ।

3. OSMF ORAL GEL™- हीिलंगप्रिक्रयाकोतेजकरनेहतेुटमेर्िरक(हल्दी)औरतुलसीकेएक्सट्रेक्टसे बना, एं

टीबैक्टीिरयल, एं टीवायरल, एं टीसेिप्टक, एन्टीइन्फ्लमेट्री और एं टीऑक्सीडटें गुणों से भरपूर ओरल जैल।

4. OSMF VITA™ - न्यूिट्रशनल सप्लीमेंट्स के पावरफु ल कॉिम्बनेशन से बना टेबलेट , जो TMJ पैन, जॉइंट

पैन, िस्टफनेस और स्वेिलं ग कम करने में असरदार है ।

यह है इक इनोवेिटव, अवाडर् िविनं ग, िक्लिनकली टेस्टेड और प्राकृ ितक OSMF ट्रीटमटें जो मुँह की अकड़ी हुई

त्वचा एवं स्नायु का लचीलापन ठीक करता है और मुँह को पयार्प्त मात्रा में खुलने में मदद करता ह।ै डॉक्टरो द्वारा

सुझाया गया यह अिद्वतीय िकट अब तक िसफर् भारत में ही नहीं बिल्क अंतराष्ट्रीय स्तर भी पर कई लोगों का

सफल उपचार कर चूका है।

गुटखा के सेवन से बंद हुए मुंह को खोलने का कारगर उपाय

What is Oral Submucous Fibrosis (OSMF Mouth Opening Kit) Introduction Treatments

क्या आपका मुँह पान-मसाला और गुटखा के सेवन के कारण नहीं खुलता ?

आज ही अपनाइये क्लिनकली टेस्टेड और प्राकृतिक बंद हुए मुंह को खोलने का कारगर उपाय ये दवा और

एक्सरसाइज करने से मुंह खोलने का इलाज घर बैठे

OSMF Mouth Opening Treatment at Home DIY Kit.

• विशेष रूप से डिज़ाइन की गई एक अनोखी किट

• ओरल सबम्यूकस फाइब्रोिसस के कारण मुंह न खुलने के इलाज में अिवश्वसनीय रूप से प्रभावी

•घरबैठेअपनेआपहीइस्तमेालकरनेकीआसानी

• सजर्री के लाखों के खचर् के सामने मामूली खचर्

•ओरलकैंसरमेंरेिडओथेरेपीके बादमुंहकमखुलनेकीसमस्यामेंभीकारगर

ओरल सबम्यूकोस फाइब्रोसिस क्या है?

श्रेष्ठ मुंह खोलने वाला व्यायाम उपकरण

मुंह के कैंसर को कैसे रोकें ?

मुंह के कैंसर का पता कैसे लगाएं?

ओरल कैंसर में रेडियोथेरेपी के बाद मुंह कम खुलने की समस्या?

अब देर किस बात की, अधिक जानकारी के लिए आज ही विजट करे या ऑनलाइन ख़रीदे

https://www.osmfmouthopeningkit.com

[irispublisherscancerresearch]

Saliva as a Diagnostic Tool in Oral Cancer- An Opinion-Iris Publishers

Authored by  Binafsha Manzoor Syed*

Abstract

Testing Saliva is a novel approach and recent research trend in diagnostics of local oral and systemic diseases as liquid biopsy. In patients with oral submucous fibrosis where biopsy further raises the risk of malignant transformation, changes in the composition of saliva including electrolytes, proteins content and presence of RNAs, tumor markers and cells as a panel can potentially be used for early detection of oral cancers.

Introduction

Saliva is a watery product of salivary glands that maintains healthy oral mucosa by preventing it from drying, lubricating and moistening hard food bolus and helping in its swallowing and also limiting the growth of pathogenic bacteria. Saliva also provides a number of enzymes that initiate food digestion, there by starting carbohydrate and fat metabolism. Saliva is produced mainly by submandibular glands (71%), parotid (25%), sublingual (3-4%) glands and only minute quantity by mucosal and labial glands [1]. The salivary secretions are under control of sympathetic and parasympathetic stimulation producing thick and thin saliva respectively. It has been suggested to be an ultrafiltrate of the blood. It contains a number of enzymes, proteins and biochemicals which come from the blood by ultrafiltration, active transport or diffusion in the salivary glands as well as others added locally such as inflammatory markers, exfoliated cells, immune cells and microorganism as part of normal flora [2]. The water content of the saliva is very high (>99%) and the quantity of rest of the factors is very low in micro and nanograms. These contents of the saliva indicate local disease and some of them have been suggested as markers of systemic diseases [2]. According to the global epidemiological data oral cancers are among relatively low prevalent cancer (accounting for 3% of all cancers in men and 2% in women) [3] as compared to breast and lung cancer, but in countries like Pakistan, India and Bangladesh with high rate of betal nut chewing and smoking oral cancers are climbing high and creating a major health issue. This exposure results in development of inflammatory response leading to chronic lesions and fibrosis with potential risk of malignancy [4]. Oral submucous fibrosis (OSMF) is a precancerous condition with high risk of malignant transformation. Biopsy of OSMF raises the risk of malignancy thus it is not indicated as a result patient are left to develop advanced disease to be diagnosed eventually causes high mortality rate after diagnosis. In a previously reported study including 1774 women of Pakistani origin, out of which 43% had OSMF only, while 26.6% has OSMF with malignancy and 30.2% had cancer without OSMF [5]. By looking at the rate of OSMF with and without cancer it can be said that the more than fifty percentage are at risk of malignant transformation which is quite high. Thus, increasing rate of oral cancers and resulting high mortality warrant alternative methods of diagnosis for oral cancer in patients with established OSMF. In this regard saliva has potential to play a role in early diagnosis of cancer. This study prevents a summary of the existing literature and theoretical framework to delineate the potential use of saliva as non-invasive biopsy for oral cancers in patients with OSMF.

Normal Composition of Human Saliva

Normal saliva is a mixture of almost all the component of plasma including water (>99%), electrolytes, enzymes, nonenzymatic proteins, immunoglobulins etc. The composition of the saliva changes with variation in the systemic circulation such as it gets thicker by reducing water contents in thirst and dehydration. The pH of the saliva also varies according to the buffering activity of the food mastication [2]. Similarly, when there is change in blood composition in disease stats there is variation in the composition of saliva. A systematic review of literature conducted recently (i.e., 2020) including 25 studies, evaluating targeted and non-targeted metabolites in cancer patients. These studies reported at least 140 metabolites out of which most frequently assessed were alanine, valine, leucine. Among breast cancer patient’s proline, threonine, and histidine in combination and monoacylglycerol showed high diagnostic potential in breast cancer patients while among patients with oral cancers choline, betaine, pipecolinic acid, and l-carnitine showed better diagnostic potential to determine early stage [6]. There is evidence suggesting altered composition of saliva in oral cancers which was not limited to any one component but there was a significant change in all the constituents ranging from electrolytes to the lipid metabolites and immunoglobulins [7]. Thus, analysis of the saliva could be a potential diagnostic tool in early detection of oral cancers.

Changes in Oral Submucous Fibrosis

In cases of smoking and betal nut chewing there are chances of accumulation of toxic chemicals damaging the mucosa [8]. In case of the failure of the antioxidant mechanism of the saliva there is a chance of chronic damage [9,10]. The oral sub mucous fibrosis and other pre-malignant lesions have shown to be associated with altered salivary composition which ranges from change in the normal constituents as well as addition of other serum markers such as interleukins and local cellular metabolites. Lactate dehydrogenase (LDH) has been reported to be significantly high in patients with OSMF and oral cancers as compared to controls [11]. Salivary chemerin showed significant difference among controls, patients with pre-malignant oral lesions and cancers. Thus, it has potential to differentiate the malignant lesions from pre-malignant conditions [12]. IL6 and IL8 have been studied and showed a significant potential in differentiating oral pre-malignant lesions from malignancy [13]. Sialic acid showed high concentration among pre-malignant and malignant lesions in the mouth as compared to healthy population [14]. The study on tumor markers including CYFRA-21-1, LDH and total protein were high among premalignant as well as in cancer patients while the comparison of the pre-malignant lesions and cancers was done the concentration was significantly higher among cancer patients [15]. A panel of biochemical components including hydrophilic metabolites, ornithine, o-hydroxybenzoate and ribose 5-Phosphatewere studied in pre-malignant and malignant lesions and reported to show high potential to differentiate between malignant and nonmalignant lesions [16]. The study suggested significant rise in the protein content of the saliva in cancer patients, there was also high electrolytes as compared to the normal controls. Immunoglobulins showed high concentration of IgG while lower concentration of IgA [7] (Figure 1).

Changes in Oral cancer

There are a number of studies which examined saliva in oral cancer patients with and without comparison with controls. A study assessed lipogenese products found a high level of free arachidonic acid and Hydroxy eicosatetraenoic acid (HETE) and high level of linoleic acid in patients with oral cancers [17]. Gene micro-array technique suggested atleast 1679 genes showing varied expression in saliva of patients with oral cancers [18]. Further probing of gene profile and mRNA analysis suggested four mRNA in saliva including OAZ, SAT, IL8, and IL1b showed high potential to diagnose oral cancer early with sensitivity of more than 90% [19]. Another study focusing on 314 mRNAs found that two mRNAs including miR-125a and miR-200a were significantly lower in patients with oral cancers [20]. Another study has reported deranged level of mRNA 24 and mRNA27b in oral cancers [21]. Yet another study has reported significantly high level of mRNA21, mRNA 184 and mRNA145 in patients with oral cancers [22]. There are other markers such as Ki67 and cyclin D1 which have been studied in multiple cancers, they have also shown significant rise in saliva in patients with oral cancers [23]. The literature suggested high transferrin levels among cancer patient’s saliva [24]. Another study evaluated transcriptomes and proteome suggested significant rise in the levels of IL8, IL1B, SAT1 and S100P transcriptomes and IL1B, IL8 and M2BP proteomes in the saliva of patients with oral cancers [25]. Other studies later also confirmed significantly high concentration of IL8 and SAT1 in oral cancer patients [26,27]. The high level of IL6 has also been reported in oral cancer when comparing with precancerous condition [28]. The analysis of the valine, lactic acid and phenylalanine as a combine tool in saliva showed high sensitivity, specificity and positive predictive value in accurately diagnosing oral cancer [29]. Serum tumor markers have also been reported to be raised in the saliva such as CA125 in patients with oral cancer [30]. Salivary e-cadherin has been reported to be very high among cancer patients [31].

Potential role of saliva as a diagnostic tool in oral submucous fibrosis in early detection of oral cancer

The brief review of literature has highlighted efforts being carried out to find a path for early diagnosis of oral cancers in situation of pre-malignant lesions. Looking at the OSMF as taking biopsy rises the risk of malignancy further resulting in high rate of advanced cancer with reduced survival. On the other hand, it is relatively easy to evaluate composition of saliva in patients with OSMF for early detection of oral cancer. The literature has shown potential chance of takin saliva as a mode of diagnosis. For that individual markers would not be able to play any significant role. Therefore, a panel of markers from all types of constitutes need to be studied together to find a reliable method. For instance, taking electrolytes, inflammatory markers (C-reactive protein, IL6, IL8), Immunoglobulins (IgG, IgA), mRNAs, proteins and tumor markers and cells together would be a practical approach.

Conclusion

Saliva has a potential for use as a non-invasive mode of liquid biopsy and can be used as surveillance, screening and early detection of oral cancers in pre-malignant conditions where oral biopsy would further raise the risk of malignant transformation. However individual markers or the same group of markers might not be helpful thus taking a panel of all types of constituents would be appropriate approach.

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