#Primary Biliary Cholangitis

[theginpu]

I need a piece of liver

Hey there. In short I'm looking for potential donors as I need a live liver transplant. I've set up a bunch of information and links over at - https://ginpuliver.carrd.co/ Even if you cannot help me directly, please share this with others. There is bound to be someone out there that can help.  Thank you all in advance.

Posted using PostyBirb

[dumbass5202]

Happy Birthday to my pookie Douglas MacArthur

He was born January 26th 1880. This ❤️cutie patookie ❤️would've been 145 if not for his unfortunate and ❤️untimely death❤️ in 1964 of primary biliary cholangitis at the ripe❤️ young age❤️ of 84.

This war HERO was UNFAIRLY called a "dumb son of a bitch" by president Truman. Truman is a dumb stinky stupid president.

[elviraaxen]

Out of all the days I could gave found out I have a rare autoimmune liver disease, the only symptoms being itchy skin OR straight up liver failure and the only cure being a full transplant, it had to be on my cats birthday? During pride month? Homophobic and petphobic. Sigh.

[nerdie-faerie]

The problem with articles not being immediately available for access, is I need very little encouragement to not do my assignment. 'Oh only the abstract is available for this article so I don't even get to decide if the research was relevant to my assignment? Great. Close tab, let's call it quits' I'm a quitter, I don't need to be tested

[santacoppelia]

Welcome! Welcome to the Magical, Mystical, Fantastical, Mysterious World of Autoimmune Whimsy, where:

My immune system hates the guts out of my joints and my liver…

We have to diminish its effectiveness, so it doesn't kill me and/or makes me suffer moving…

Therefore, I am at risk of curious infections (like the one colonizing my nose and eyes this week)…

Which are a real problem to treat, because my autoimmune sensitive liver must be protected from almost any medicine created by men or women.

Yeah, not being my happiest lately.

[does-truth-matter]

The CDC has quietly changed who should AVOID the MMR vaccine.

https://www.cdc.gov/vaccines/vpd/mmr/public/index.html

They now state that ANYONE that “Has a parent, brother or sister with a history of immune system problems” should AVOID THE MMR VACCINE!

What exactly is an 'immune system problem?" Every autoimmune disorder.

* Achalasia

* Addison’s disease

* Adult Still's disease

* Agammaglobulinemia

* Alopecia areata

* Amyloidosis

* Amyotrophic lateral sclerosis (Lou Gehrigs)

* Ankylosing spondylitis

* Anti-GBM/Anti-TBM nephritis

* Antiphospholipid syndrome

* Autoimmune angioedema

* Autoimmune dysautonomia

* Autoimmune encephalomyelitis

* Autoimmune hepatitis

* Autoimmune inner ear disease (AIED)

* Autoimmune myocarditis

* Autoimmune oophoritis

* Autoimmune orchitis

* Autoimmune pancreatitis

* Autoimmune retinopathy

* Autoimmune urticaria

* Axonal & neuronal neuropathy (AMAN)

* Baló disease

* Behcet’s disease

* Benign mucosal pemphigoid

* Bullous pemphigoid

* Castleman disease (CD)

* Celiac disease

* Chagas disease

* Chronic inflammatory demyelinating polyneuropathy (CIDP)

* Chronic recurrent multifocal osteomyelitis (CRMO)

* Churg-Strauss Syndrome (CSS) or Eosinophilic Granulomatosis (EGPA)

* Cicatricial pemphigoid

* Cogan’s syndrome

* Cold agglutinin disease

* Congenital heart block

* Coxsackie myocarditis

* CREST syndrome

* Crohn’s disease

* Dermatitis herpetiformis

* Dermatomyositis

* Devic’s disease (neuromyelitis optica)

* Discoid lupus

* Dressler’s syndrome

* Endometriosis

* Eosinophilic esophagitis (EoE)

* Eosinophilic fasciitis

* Erythema nodosum

* Essential mixed cryoglobulinemia

* Evans syndrome

* Fibromyalgia

* Fibrosing alveolitis

* Giant cell arteritis (temporal arteritis)

* Giant cell myocarditis

* Glomerulonephritis

* Goodpasture’s syndrome

* Granulomatosis with Polyangiitis

* Graves’ disease

* Guillain-Barre syndrome

* Hashimoto’s thyroiditis

* Hemolytic anemia

* Henoch-Schonlein purpura (HSP)

* Herpes gestationis or pemphigoid gestationis (PG)

* Hidradenitis Suppurativa (HS) (Acne Inversa)

* Hypogammalglobulinemia

* IgA Nephropathy

* IgG4-related sclerosing disease

* Immune thrombocytopenic purpura (ITP)

* Inclusion body myositis (IBM)

* Interstitial cystitis (IC)

* Juvenile arthritis

* Juvenile diabetes (Type 1 diabetes)

* Juvenile myositis (JM)

* Kawasaki disease

* Lambert-Eaton syndrome

* Leukocytoclastic vasculitis

* Lichen planus

* Lichen sclerosus

* Ligneous conjunctivitis

* Linear IgA disease (LAD)

* Lupus

* Lyme disease chronic

* Meniere’s disease

* Microscopic polyangiitis (MPA)

* Mixed connective tissue disease (MCTD)

* Mooren’s ulcer

* Mucha-Habermann disease

* Multifocal Motor Neuropathy (MMN) or MMNCB

* Multiple sclerosis

* Myasthenia gravis

* Myositis

* Narcolepsy

* Neonatal Lupus

* Neuromyelitis optica

* Neutropenia

* Ocular cicatricial pemphigoid

* Optic neuritis

* Palindromic rheumatism (PR)

* PANDAS

* Parkinson's disease

* Paraneoplastic cerebellar degeneration (PCD)

* Paroxysmal nocturnal hemoglobinuria (PNH)

* Parry Romberg syndrome

* Pars planitis (peripheral uveitis)

* Parsonage-Turner syndrome

* Pemphigus

* Peripheral neuropathy

* Perivenous encephalomyelitis

* Pernicious anemia (PA)

* POEMS syndrome

* Polyarteritis nodosa

* Polyglandular syndromes type I, II, III

* Polymyalgia rheumatica

* Polymyositis

* Postmyocardial infarction syndrome

* Postpericardiotomy syndrome

* Primary biliary cirrhosis

* Primary sclerosing cholangitis

* Progesterone dermatitis

* Psoriasis

* Psoriatic arthritis

* Pure red cell aplasia (PRCA)

* Pyoderma gangrenosum

* Raynaud’s phenomenon

* Reactive Arthritis

* Reflex sympathetic dystrophy

* Relapsing polychondritis

* Restless legs syndrome (RLS)

* Retroperitoneal fibrosis

* Rheumatic fever

* Rheumatoid arthritis

* Sarcoidosis

* Schmidt syndrome

* Scleritis

* Scleroderma

* Sjögren’s syndrome

* Sperm & testicular autoimmunity

* Stiff person syndrome (SPS)

* Subacute bacterial endocarditis (SBE)

* Susac’s syndrome

* Sympathetic ophthalmia (SO)

* Takayasu’s arteritis

* Temporal arteritis/Giant cell arteritis

* Thrombocytopenic purpura (TTP)

* Tolosa-Hunt syndrome (THS)

* Transverse myelitis

* Type 1 diabetes

* Ulcerative colitis (UC)

* Undifferentiated connective tissue disease (UCTD)

* Uveitis

* Vasculitis

* Vitiligo

* Vogt-Koyanagi-Harada Disease

Wonder how many doctors are paying attention?

~shared from Jodi Wilson

[lvmimis]

i’m dead so i had a mini panic cuz i thought j had remembered this acronym wrong from school - primary biliary cirrhosis vs primary biliary cholangitis - cuz i kept getting confused as to why the gi docs kept saying pbc complicated by cirrhosis cuz it’s redundant, i look it up and it’s primary biliary cholangitis and i’m like omg have i been stupid for like six years and turns out that like actually they only changed the name in 2014 so that’s why i learned it that way 😭 (although i started school shortly after that but they take a while to change nomenclature)

net zero information

[liizzarddd]

So I have limited scleroderma with primary biliary cholangitis.

Don’t ask me what that means because I’m still learning myself.

It’s so crazy because I told all my friends I feel like now that I’m doing so great mentally, now it’s my body geeking out on me. I just knew. It’s nice to finally have answers.

[darkmaga-returns]

For nearly three decades, Periodic Safety Update Reports (PSURs) have been vital for the continuous safety evaluation of medicinal products, ensuring their risk-benefit balance stays favourable over time. Data from Post-Marketing Surveillance included in the PSURs showing a pattern of safety issues could potentially lead to the revocation of a medicinal product's authorization.

For instance, in 2021, the European Medicines Agency (EMA) recommended the revocation of the conditional marketing authorization for Ocaliva (obeticholic acid) due to concerns over liver injury risks. The review highlighted that the benefits of Ocaliva no longer outweighed its risks in treating Primary Biliary Cholangitis (PBC). This decision was influenced by safety data from PSURs and other pharmacovigilance information.

Initially granted marketing authorization in 2006, Acomplia (rimonabant), an anti-obesity drug, had its authorization revoked two years later. This was due to serious psychiatric side effects, including depression and an increased risk of suicide, which were identified through post-marketing surveillance and PSUR data.

Yet, for the experimental Covid shots- the disturbing pattern of safety issues gleaned from the PSURs have been ignored by the regulators, who have continually concluded that the risk-benefit balance remains “favourable.”

[brookston]

Holidays 9.8

Holidays

Actor’s Day

Asturias Day (Spain)

Blondie Day

Blue’s Clues Day

Colorism Awareness Day

The Commemoration of the Two Sieges (Malta)

Community Day (Extramadura, Spain)

Coronation Anniversary of Vytautas the Great (Lithuania)

Day of Aid Workers

Day of Asturias (Spain)

Day of the Battle of Borodino (Russia)

Extramadura Day (Spain)

Father’s Day (Latvia)

Festa Della Rificolona ends (Paper Lantern Festival; Florence, Italy)

Fiestas de Santa Fe begins with the burning of the Zozobra (New Mexico)

Financier’s Day (Russia)

Grandparents’ & Family Caregivers’ Day (Florida)

Hazelnut Day (French Republic)

Iguana Awareness Day

International Day of Journalists

International Literacy Day (UN)

Kosrae Liberation Day (Micronesia)

La Vierge de Meritxell (Feast of Our Lady of Meritxell; Andorra)

Mariä Geburt (Liechtenstein)

Martyrs’ Day (a.k.a. Massoud Day; held on Shahrivar 18) [Can be 9.8 or 9.9]

Matki Boskiej Zielnej (a.k.a. Fest of Greenery; Poland)

Meritxell Day (Andorra)

National Actors Day

National Ampersand Day

National David Day

National Dog Walker Appreciation Day

National Double Merle Awareness Day

National Essential Medicine Shortages Awareness Day

National Iguana Awareness Day

National Lissencephaly Awareness Day

National Neighborhood Day

National Pardon Day

908 Day

Nuakhai (Odisha, India)

Onam ends (India)

Pardon Me Day

Pediatric Hematology/Oncology Nurses Day

Pledge of Allegiance Day

Sirona Asteroid Day

Solidarity Day of World Heritage Cities

Star Trek Day

Tank Crewman’s Day (Russia)

Turkmen Bakhshi Day (Turkmenistan)

Victory Day (Malta)

Volunteer Day (Spain)

World Gravity Day

World Physical Therapy Day

Worldwide Cystic Fibrosis Day

Food & Drink Celebrations

Bacon Burger Day

Date Nut Bread Day

International Day of Papaya

International Food Delivery Day

National Merlot Day (South Africa)

Independence & Related Days

Alsann (Declared; 2022) [unrecognized]

Andorra (Nation founded, 1728)

Macedonia (from Yugoslavia, 1991)

Seybold (Declared; 2018) [unrecognized]

2nd Sunday in September

Auditor's Day (Scientology) [2nd Sunday]

Day of Lake Baikal (Russia) [2nd Sunday]

Day of Open Monuments (Germany) [2nd Sunday]

Day of the Homeland (Germany) [2nd Sunday]

Education Day (UK) [2nd Sunday]

Family Day (Kazakhstan) [2nd Sunday]

Fjord Day (Denmark) [2nd Sunday]

Grandparent's Day (Canada) [Sunday after 1st Monday]

Great Procession of Tournai (Belgium) [2nd Sunday]

Hug Your Hound Day [2nd Sunday]

Joust of the Quintana: La Rivincita (The Rematch; Italy) [2nd or 3rd Sunday, Pt. 1 in July]

National Bilby Day (Australia) [2nd Sunday]

National Dementia Carers Day (UK) [2nd Sunday]

National Education Sunday (UK) [2nd Sunday]

National Firefighters’ Memorial Day (Canada) [2nd Sunday]

National Pet Memorial Day [2nd Sunday]

PBC (Primary Biliary Cholangitis) Awareness Day [2nd Sunday]

Racial Justice Sunday [2nd Sunday]

Remembrance Day for Victims of Fascism [2nd Sunday]

Road Workers Day (Tajikistan) [2nd Sunday]

Sandwich Sunday [2nd Sunday of Each Month]

Sleepy Sunday [2nd Sunday of Each Month]

Seven For Sunday [Every Sunday]

Sundae Sunday [Every Sunday]

Sunday Funday [Every Sunday]

Survey Sunday [2nd Sunday of Each Month]

Sustainable House Day (Australia) [2nd Sunday]

Turkmen Bakshy Day [2nd Sunday]

Vanavanemate Päev (Estonia) [2nd Sunday]

Workers of Natural Gas and Petroleum Industry Day (Ukraine) [2nd Sunday]

Weekly Holidays beginning September 8 (2nd Full Week of September)

Folic Acid Awareness Week (thru 9.14)

Healthcare Environmental Services Week (thru 9.14) [2nd Full Week]

International Housekeepers Week (thru 9.14) [2nd Full Week]

National Arts in Education Weeks (thru 9.14) [From 2nd Sunday]

National Assisted Living Week (thru 9.14) [2nd Full Week]

National Beauty and Barber Week (thru 9.14) [2nd Full Week]

National Biscuit and Gravy Week (thru 9.14) [2nd Full Week]

National Compassionate Leadership Week (thru 9.14) [2nd Full Week]

National Environmental Services Week (thru 9.14) [2nd Full Week]

National Nephrology Nurses Week (thru 9.14) [2nd Full Week]

National Suicide Prevention Week (thru 9.14) [2nd Full Week]

Festivals Beginning September 8, 2024

Austin Chronicle Hot Sauce Festival (Austin, Texas)

Bean Soup Festival & Fair (McClure, Pennsylvania) [thru 9.14]

Bloemencorso Lichtenvoorde (Lichtenvoorde, Netherlands)

Bloemencorso Loenhout (Loenhout, Belgium)

Cambridge Carnival (Cambridge, Massachusetts)

Fiddles Vittles and Vino (Colorado Springs, Colorado)

Heritage Fire (Willamette Valley, Oregon)

International Alexandrinsky Theatre Festival (Saint Petersburg, Russia) [thru 10.30]

Manifesta [European Nomadic Biennial] (Barcelona, Spain) [thru 11.24]

Feast Days

Adrian and Natalia of Nicomedia (Roman Catholic Church)

Adrian of Nicomedia (Christian; Saint Feast Day) [brewers, middle England's brewers guild] *

Ann Beattie (Writerism)

Archie Goodwin (Artology)

Carnot (Positivist; Saint)

Corbinian (Christian; Saint)

Disibod (a.k.a. Disen or Disbode; Christian; Saint)

Eusebius, Nestablus, Zeno, and Nestor (Christian; Martyrs)

Feast of Honor for Lada and Leda (Bread & Harvest Festival; Slavic Pagan/Asatru)

Feast of ‘Izzat (Might; Baha’i)

Feast of Papa-Lea (God of Kava Drinking)

Frédéric Mistral (Writerism)

Il-Vittorja (a.k.a. Feast of Our Lady of Victories; Malta)

Jill St. John Day (Church of the SubGenius; Saint)

Mead Day (Pagan)

Michael Frayn (Writerism)

Mimi Parent (Artology)

Monti Fest (Mangalorean Catholic; Parts of India)

Morty Moot Mope (Muppetism)

Nativity of Mary (Roman Catholic Church, Anglo-Catholicism)

Our Lady of Charity (Christian; Saint)

Our Lady of Covadonga (Christian; Saint)

Our Lady of Good Health of Vailankanni (Christian; Saint)

Our Lady of Meritxell (Andorra; Christian; Saint)

Ozias Humphry (Artology)

Paradoxically Non-Paradoxical Day (Pastafarian)

Sergius I, Pope (Christian; Saint)

Theosophy Day

Vicious Sex Day (Pastafarian)

Virgin Mary Day

Lucky & Unlucky Days

Fortunate Day (Pagan) [36 of 53]

Prime Number Day: 251 [54 of 72]

Sensho (先勝 Japan) [Good luck in the morning, bad luck in the afternoon.]

Premieres

Ally McBeal (TV Series; 1997)

Betty Crocker's Cookbook, by the Betty Crocker Editors (Cookbook; 1950)

Blue’s Clues (Children’s TV Series; 1996)

Bone Machine, by Tom Waits (Album; 1992)

Boys Town (Film; 1938)

The Breadwinner (Animated Film; 2017)

Brigadoon (Film; 1954)

Carnival Courage (Color Rhapsody Cartoon; 1945)

Cat's Cradle, by Kurt Vonnegut Jr. (Novel; 1963)

Catty-Cornered (Tom & Jerry Cartoon; 1966)

Cold Comfort Farm, by Stella Gibbons (Novel; 1932)

Cosmicomics, by Italo Calvino (Short Stories; 1965)

The Cyberiad, by Stanisław Lem (Short Stories; 1965)

The Eagle Has Landed, by Jack Higgins (Novel; 1975)

Everglade Raid (Woody Woodpecker Cartoon; 1958)

Frank Sinatra Sings for Only the Lonely, by Frank Sinatra (Album; 1958)

God Bless You, Mr. Rosewater, by Kurt Vonnegut Jr. (Novel; 1965)

Havana, by Camila Cabello (Song; 2017)

Hitchhiker, by Neil Young (Album; 2017)

Hold Your Fire, by Rush (Album; 1987)

iCarly (TV Series; 2007)

I Just Can’t Get You Out of My Head, by Kylie Minogue (Song; 2001)

It (Film; 2017)

Jeannie (Animated TV Series; 1973)

Jonathan Strange & Mr Norrell, by Susanna Clarke (Novel; 2004)

The Last of the Really Great Whangdoodles, by Julie Andrews Edwards (Children’s Book; 1974)

Lost in Space (Hanna-Barbera Animated TV Film; 1973)

Lovelorn Leghorn (WB LT Cartoon; 1951)

Make Me, 20th Jack Reacher book, by Lee Child (Novel; 2015)

Mouse-Warming (WB LT Cartoon; 1952)

Never for Ever, by Kate Bush (Album; 1980)

Nurse Betty (Film; 2000)

The Oprah Winfrey Show (Daytime TV Series; 1986)

Psycho (Film; 1960)

The Pure and the Impure, by Colette (Novel; 1932)

Purr-Chance to Dream (Tom & Jerry Cartoon; 1967)

Scalp Treatment (Woody Woodpecker Cartoon; 1952)

Second Foundation, by Isaac Asimov (Novel; 1953) [Foundation #3]

The Sirens of Titan, by Kurt Vonnegut Jr. (Novel; 1959)

Slicked-Up Pup (Tom & Jerry Cartoon; 1951)

Song of Victory (Color Rhapsody Cartoon; 1942)

Star Trek (TV Series; 1966)

Suffer, by Bad Religion (Album; 1988)

Today’s Name Days

Adrian, Mariä Geburt (Austria)

Hadrijan, Maja, Marija, Sergije (Croatia)

Mariana (Czech Republic)

Maria (Denmark)

Mariann, Marianna, Marianne (Estonia)

Taimi (Finland)

Adrien, Béline (France)

Adrian, Mariä Geburt, Otmar (Germany)

Despoina, Genethlios, Skiadeni, Tsampika (Greece)

Adrienn, Mária (Hungary)

Immacolata, Maria (Italy)

Amirs, Ilga, Ilgonis, Nelda (Latvia)

Daumantė, Klementina, Liaugaudas, Vytautas (Lithuania)

Allan, Alma, Amalie (Norway)

Adrian, Adrianna, Klementyna, Maria, Nestor, Radosław, Radosława (Poland)

Natalia (Russia)

Miriama (Slovakia)

Cinta, Covadonga, Fuensanta, Meritxell, Natividad, Nazaret, Nuria, Sagrario, Sergio (Spain)

Alma, Hulda (Sweden)

Maria, Mary (Ukraine)

Adria, Adrian, Adriana, Adrianna, Adrien, Adrienne, Hadria, Hadrian, Hadrien, Joachim, Joakima, Joaquin, Joaquina (USA)

Today is Also…

Day of Year: Day 252 of 2024; 114 days remaining in the year

ISO: Day 7 of Week 36 of 2024

Celtic Tree Calendar: Muin (Vine) [Day 8 of 28]

Chinese: Month 8 (Guy-You), Day 6 (Yi-Hai)

Chinese Year of the: Dragon 4722 (until January 29, 2025) [Wu-Chen]

Hebrew: 5 Elul 5784

Islamic: 4 Rabi I 1446

J Cal: 12 Gold; Fryday [11 of 30]

Julian: 26 August 2024

Moon: 25%: Waxing Crescent

Positivist: 28 Gutenberg (9th Month) [Mont]

Runic Half Month: Ken (Illumination) [Day 2 of 15]

Season: Summer (Day 81 of 94)

Week: 2nd Full Week of September

Zodiac: Virgo (Day 18 of 32)

[expertacademicassignmenthelp]

The Physiology Of The Liver

The liver is a vital organ responsible for numerous functions including metabolism, immunity, digestion, detoxification, and vitamin storage. It weighs around 2% of an adult’s body weight and is unique due to its dual blood supply from the portal vein (75%) and the hepatic artery (25%).

Cellular Structure

The liver’s functional unit is the lobule, which is hexagonal in shape. Each corner of the hexagon has a portal triad consisting of the portal vein, hepatic artery, and bile duct. The lobule is composed mainly of hepatocytes, which have distinct apical and basolateral membranes. Hepatocytes are categorized into three zones based on their function and blood supply:

Zone I (periportal region): Closest to the blood supply, involved in oxidative metabolism (e.g., gluconeogenesis, bile formation).

Zone II (pericentral region): Sits between Zones I and III.

Zone III: Farthest from the blood supply, primarily involved in detoxification and biotransformation.

Blood and bile flow in opposite directions within the liver. The space of Disse, between the hepatocytes and the sinusoidal lumen, contains Kupffer cells (macrophages) and Ito cells (fat-storing stellate cells).

Development

The liver develops from endodermal cells of the foregut as the hepatic diverticulum around the fourth week of embryonic development. It undergoes complex differentiation influenced by various pathways (e.g., Wnt/β-catenin, FGF). By the sixth week, the liver participates in hematopoiesis, and hepatocytes begin bile production by the 12th week.

Organ Systems and Functions

The liver interacts with multiple body systems:

Digestive and Metabolic Roles: Aids in digestion, stores fat-soluble vitamins, and handles cholesterol.

Hematological Functions: Produces clotting factors and proteins.

Detoxification: Metabolizes drugs and other xenobiotics through phase I (oxidation, reduction, hydrolysis) and phase II (conjugation) reactions.

Bilirubin Metabolism: Converts heme to unconjugated bilirubin, then conjugates it for excretion.

Hormonal and Protein Synthesis: Involved in thyroid hormone activation and synthesis of nearly all plasma proteins.

Related Testing

Liver function tests (LFTs), including ALT, AST, bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase (GGT), help assess liver health. Imaging techniques like ultrasound, CT, and MRI are also employed to identify liver abnormalities.

Pathophysiology

Cirrhosis results from chronic liver injury (e.g., due to alcoholism, hepatitis B and C), leading to fibrosis and necrosis. It causes symptoms like portal hypertension, coagulopathy, and jaundice. Hepatitis viruses (A, B, C, D, E), autoimmune diseases (e.g., primary biliary cholangitis), and metabolic conditions (e.g., non-alcoholic fatty liver disease) also contribute to liver pathology.

Clinical Significance

Understanding liver physiology helps manage conditions like viral hepatitis, alcoholic liver disease, benign liver lesions, and liver cancers. Early detection through appropriate testing and management strategies is essential for preventing end-stage liver disease and improving patient outcomes

As academic students and researchers navigate the challenges of their assignments and research endeavors, Expert Academic Assignment Help stands ready to provide professional guidance and assistance. Whether you require support with assignment writing, research paper assistance, or essay help, our team of experts is dedicated to helping you achieve academic excellence. Reach out to us today at expertassignment46@gmail.com and let us support you on your academic journey. We wish you success and professional excellence.

[dr-smita-goel-homeopathy-clinic]

*DR. SMITA GOEL HOMEOPATHY CLINIC*

www.thehomeopathyclinic.co.in

The liver is a largest, meaty organ. It has weight about 3 pounds, the liver is reddish-brown in colour and feels rubbery to the touch. Normally you can't feel the liver, because it's protected by the rib cage.

The liver has two large sections, called the right and the left lobes. The gallbladder sits under the liver, along with parts of the pancreas and intestines. The liver and these organs work together to digest, absorb, and process food.

The liver's main job is to filter the blood coming from the digestive tract, before passing it to the rest of the body. The liver also detoxifies chemicals and metabolizes drugs. As it does so, the liver secretes bile that ends up back in the intestines. The liver also makes proteins important for blood clotting and other functions.

There are following types of liver disease:

• Hepatitis: Inflammation of the liver, usually caused by viruses like hepatitis A, B, and C. Hepatitis can have non-infectious causes too, including heavy drinking, drugs, allergic reactions, or obesity.

• Cirrhosis: Long-term damage to the liver from any cause can lead to permanent scarring, called cirrhosis. The liver then becomes unable to function well.

• Liver cancer: The most common type of liver cancer, hepatocellular carcinoma, almost always occurs after cirrhosis is present.

• Liver failure: Liver failure has many causes including infection, genetic diseases, and excessive alcohol.

• Ascites: As cirrhosis results, the liver leaks fluid (ascites) into the belly, which becomes distended and heavy.

• Gallstones: If a gallstone becomes stuck in the bile duct draining the liver, hepatitis and bile duct infection (cholangitis) can result.

• Hemochromatosis: Hemochromatosis allows iron to deposit in the liver, damaging it. The iron also deposits throughout the body, causing multiple other health problems.

• Primary sclerosing cholangitis: A rare disease with unknown causes, primary sclerosing cholangitis causes inflammation and scarring in the bile ducts in the liver.

• Primary biliary cirrhosis: In this rare disorder, an unclear process slowly destroys the bile ducts in the liver. Permanent liver scarring (cirrhosis) eventually develops.

[elviraaxen]

In case y’all missed it, I was diagnosed with Primary biliary cholangitis which is a degenerative, albeit slow, autoimmune disorder of the liver, specifically the bile ducts. Here are the main points:

Am I ok? So far yes. No visible damage on my liver yet.

Is there treatment? Yes, there are medications to slow the damage on the liver, although a significant portion of patients don’t respond to it.

Is it dangerous? If it progresses to cirrhosis, yes. You will go into liver failure. Not all PBC patients develop cirrhosis though, and the disorder is very very slowly progressing, you’ll clock it long before it happens.

Is there a cure? Yes, a liver transplant. :/

Are you feeling symptoms? Nope, none at all. PBC has two main symptoms: fatigue and itchy skin (weird). Most patients are asymptomatic for the first 5-10 years thankfully.

Are you like Okay okay? *nods side to side* eeeeh ? :/ I’ll have my crisis later I don’t feel like it.

[justagalwhowrites]

I used to work on autoimmune liver disease, specifically primary biliary cholangitis.

Sometimes, when I'm reading, I will catch a familiar or weird word lower on the page with my peripheral vision before I'm actually reading the sentence (aka my brain trying to spoil things). That happened in the last Lavender chapter when I saw cholecystitis! I was like, wait, whaaaat? Why we talking about bile flow, friend??" Girl, your research is appreciated!

Ahhhhh! Bestie!!!

This is so cool lmfao

I do really like to try to be accurate when I include things in fics or novels? I'm a former journalist so I really like to be factually accurate lol I'm glad it paid off because I spent a lot of time reading about that the other day 😂

Thank you for making it not feel like a waste!! Love you!

[drvinothkumar]

What Are the Risk Factors for Developing Jaundice?

Jaundice, characterized by the yellowing of the skin and eyes, occurs due to an accumulation of bilirubin in the bloodstream. While it can affect people of all ages, certain risk factors increase the likelihood of developing jaundice. Identifying and addressing these risk factors is essential for prevention and effective management. Hospitals specializing in urology treatment in Coimbatore provide comprehensive care and guidance to minimize the risks associated with jaundice.

Common Risk Factors for Developing Jaundice

Liver Diseases:

Conditions like hepatitis, cirrhosis, and liver cancer significantly increase the risk of jaundice by impairing the liver's ability to process bilirubin.

Gallbladder and Bile Duct Disorders:

Gallstones, bile duct obstructions, or strictures can block bile flow, leading to bilirubin buildup and jaundice.

Excessive Alcohol Consumption:

Chronic alcohol use can lead to liver damage or alcoholic hepatitis, a major contributor to jaundice.

Viral Infections:

Hepatitis A, B, or C infections directly affect liver function, increasing the likelihood of jaundice.

Hemolytic Anemia:

Rapid breakdown of red blood cells in conditions like hemolytic anemia leads to excessive bilirubin production, overwhelming the liver’s capacity to process it.

Neonatal Factors:

Newborns are at higher risk due to immature liver function, especially in cases of preterm birth or inadequate breastfeeding.

Genetic Disorders:

Inherited conditions such as Gilbert’s syndrome or Crigler-Najjar syndrome affect bilirubin metabolism and increase the risk of jaundice.

Obesity and Fatty Liver Disease:

Non-alcoholic fatty liver disease (NAFLD) caused by obesity or poor diet can impair liver function and increase the likelihood of jaundice.

Certain Medications:

Drugs like acetaminophen, steroids, and certain antibiotics can cause liver damage or disrupt bile flow, leading to jaundice.

Autoimmune Diseases:

Conditions like autoimmune hepatitis or primary biliary cholangitis involve the immune system attacking liver cells or bile ducts, increasing jaundice risk.

Malaria and Parasitic Infections:

Infections like malaria destroy red blood cells and can cause jaundice, particularly in endemic regions.

Toxin Exposure:

Chemicals, toxins, or harmful substances that damage liver cells increase the risk of jaundice.

How to Reduce the Risk of Developing Jaundice

Adopt a Healthy Lifestyle:

Maintain a balanced diet rich in fruits, vegetables, and whole grains while avoiding excessive alcohol consumption and processed foods.

Get Vaccinated:

Vaccines for hepatitis A and B are effective in preventing viral infections that can lead to jaundice.

Regular Medical Checkups:

Routine health evaluations can detect liver or bile duct issues early. Hospitals offering urology treatment in Coimbatore provide advanced diagnostics to identify and manage risks.

Stay Hydrated:

Proper hydration supports liver function and helps eliminate toxins from the body.

Avoid Self-Medication:

Use medications only under medical supervision to prevent liver damage caused by drug toxicity.

Protect Against Infections:

Practice good hygiene, avoid contaminated food or water, and take precautions when traveling to areas with endemic infections.

Expertise in Urology Treatment in Coimbatore

Hospitals specializing in urology treatment in Coimbatore provide cutting-edge care for jaundice. From identifying risk factors to offering tailored treatment plans, these centers ensure comprehensive management and prevention strategies.

The Importance of Proactive Care

Addressing risk factors early can prevent the onset of jaundice and reduce the chances of complications like chronic liver disease or bile duct disorders.

If you or a loved one is at risk of jaundice, consult specialists at leading centers for urology treatment in Coimbatore to receive expert care and personalized advice in GEM hospitals.

Book your appointment today to safeguard your health and prevent jaundice effectively.

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