#Transdermal Drug Delivery

[therabbitparade]

Being on T gel is so funny cuz everyday i have to pop the top on a little metal paint-tube full of the most nightmareishly sticky goo and slather it on a fairly small surface area (shoulders and upper arms ONLY) and the package and medication guides and inserts have stickers and bolded warnings all over them abt how not to get near women or children too soon after application or they will be IN DANGER and i just like.... stay silly :3

[businesspointnews]

Transdermal Drug Delivery Systems Market Size, Share, Demand, Growth Drivers , Key Players and Forecast 2023-2028

IMARC Group has recently released a new research study titled “Transdermal Drug Delivery Systems Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2023-2028”, offers a detailed analysis of the market drivers, segmentation, growth opportunities, trends and competitive landscape to understand the current and future market scenarios.How big is the transdermal drug…

[desaletushki]

Transdermal Drug Delivery System Market Revenue Forecast 2030

Transdermal Drug Delivery System Market Growth & Trends

The global transdermal drug delivery system market is expected to reach USD 145.0 billion by 2030, registering a CAGR of 11.9% from 2023 to 2030, according to a new report by Grand View Research, Inc. Increasing adoption of transdermal patches, such as in the case of diabetes, which requires sustained and a daily dose of insulin is expected to provide the market with growth opportunities during the forecast period.

High demand for pain-free drug delivery is a major driving factor of the transdermal drug delivery systems market. In the case of diabetes, insulin has to be administered into the patient's body with the help of injections on a continuous basis. Continuous usage of injections to deliver insulin causes pain and increases the risk of transmission of chronic diseases, thus, making transdermal patches a better choice for delivering insulin in diabetic patients.

Request a free sample copy or view the report summary: https://www.grandviewresearch.com/industry-analysis/transdermal-drug-delivery-systems-industry

COVID-19 led to a significant fall in sales of transdermal drug delivery systems. This is because most of these drugs are prescribed drugs and the pandemic led to a sharp fall in patient visits to healthcare facilities. Factors such as lockdowns and travel restrictions led down by the government, to curb the spread of the virus, resulted in reduced patient visits. In addition, many individuals in order to avoid physical contact also avoided visiting healthcare facilities, as a precautionary measure.

However, with the world moving towards normalcy and various pharma companies focusing on developing new novel products, the market represents great opportunities for growth. Moreover, increasing investments by the government in R&D and healthcare are further accelerating the demand for transdermal drug delivery systems in the market.

Transdermal Drug Delivery System Market Report Highlights

The iontophoresis segment dominated the market in 2022 owing to its efficacy in delivering drugs. The mechanical arrays segment is expected to maximum growth due to the increasing number of product launches

The pain management segment accounted for the highest market share in 2022 due to increasing demand for transdermal patches used for pain management

The cardiovascular segment is anticipated to experience maximum growth during the forecast period due to the increasing utilization of these systems in the treatment of cardiovascular diseases

North America accounted for the highest market share in 2022 owing to a rise in investments by existing as well as new market players

Increasing healthcare expenditure and huge investments in research and development represent lucrative growth opportunities in the Asia Pacific region

Transdermal Drug Delivery System Market Segmentation

Grand View Research has segmented the global transdermal drug delivery system market based on technology, application, and region:

Transdermal Drug Delivery System Technology Outlook (Revenue in USD Million, 2018 - 2030)

Electroporation

Radio Frequency

Iontophoresis

Microporation

Thermal

Mechanical arrays

Ultrasound

Others

Transdermal Drug Delivery System Application Outlook (Revenue in USD Million, 2018 - 2030)

CNS

Pain Management

Cardiovascular

Hormone

Immunological

Metabolic

Gastrointestinal

Infection

Cancer

Others

Urological

Blood disorders

Respiratory

Musculoskeletal

Regional Insights

North America held a sizeable share of more than 58.2% in 2022. The growth in this region is majorly driven by patent expirations, resulting in more companies entering the market. In addition, repositioning of previously failed drugs, reformulation of existing drug compounds, and huge investments undertaken by the prominent as well as new market entrants are also presumed to be the key factors responsible for the substantial share captured by this region.

Factors such as favorable reimbursement scenarios and rising awareness by government organizations in Europe are contributing to the growth of the transdermal drug delivery system market in the region. Well-developed healthcare structure that covers the healthcare costs of the citizens, promotes more people opting for treatment in the region. This is expected to further boost the market growth during the forecast period.

The Asia Pacific market is anticipated to exhibit the fastest CAGR of above 13.4% during the forecast period, attributable to the growing healthcare spending and the rapidly evolving healthcare infrastructure. In addition, the growth is due to the high research and development intensity as well as the growing awareness in emerging economies, such as China and India.

List of Key Players in Transdermal Drug Delivery System Market

Novartis AG

Johnson & Johnson

Mylan Pharmaceuticals, Inc.

Boehringer Ingelheim GmbH

Biogel Technology, Inc.

Transdermal Technologies, Inc.

Skyepharma, Watson Pharmaceuticals, Inc.

3M Company

Noven Pharmaceuticals, Inc.

4P Therapeutics, LLC

Transdermal Corporation

Echo Therapeutics, Inc.

Authoritative Research: https://www.grandviewresearch.com/industry-analysis/transdermal-drug-delivery-systems-industry

[qy-research-medical]

The U.S. transdermal drug delivery system market size was valued at USD 31.31 billion in 2022 and is expected to expand at a compound annual growth rate (CAGR) of 12.4% from 2023 to 2032.

[poojaj]

Excellent growth of Transdermal Drug Delivery System Market

The transdermal drug delivery system market refers to the global market for drug delivery systems that use the skin as a route of administration. Transdermal drug delivery systems are used to deliver drugs through the skin and into the bloodstream, and are used in the treatment of a wide range of conditions, including pain management, hormone replacement therapy, nicotine addiction, and cardiovascular disease.

For Sample Report Click Here:-https://www.globmarketreports.com/request-sample/202344

The global transdermal drug delivery system market is expected to experience significant growth in the coming years, driven by factors such as the increasing prevalence of chronic diseases, the growing demand for non-invasive drug delivery systems, and the increasing adoption of transdermal drug delivery systems by pharmaceutical companies.

North America is expected to be the largest market for transdermal drug delivery systems, due to the high prevalence of chronic diseases, the presence of a well-established healthcare infrastructure, and the increasing adoption of advanced transdermal drug delivery systems. The Asia-Pacific region is also expected to experience significant growth in the coming years, driven by factors such as the increasing demand for non-invasive drug delivery systems and the growing focus of pharmaceutical companies on developing innovative transdermal drug delivery systems.

A transdermal drug delivery system (TDDS) is a medical technology that enables the transfer of drugs or other therapeutic agents through the skin and into the bloodstream. The system consists of a patch that is applied to the skin, which contains the drug in a specific formulation that allows it to penetrate the skin layers and reach the bloodstream.

TDDS has several advantages over traditional drug delivery methods, such as oral or injectable administration. It can provide a controlled and continuous release of the drug over a prolonged period of time, ensuring consistent blood levels of the drug. It also avoids the first-pass metabolism of the liver, which can reduce the effectiveness of the drug and cause unwanted side effects.

[jgbgff]

Transdermal Drug Delivery System Market Size, Share & Trends, Product, Region & Forecasts 2030

Transdermal Drug Delivery System Market Size, Share & Trends, Product, Region & Forecasts 2030

Description The impact of a number of factors such as economic, legal, social, political, technological, and modern business developments on market dynamics is briefly examined in the Transdermal Drug Delivery System market analysis. The global Transdermal Drug Delivery System market analysis focuses on market share and competitiveness index, which helps evaluate the top player’s contributions to…

[baeddelicto]

This includes legal drugs like nicotine, caffeine, etc.

[unwelcome-ozian]

What information do you have about Johnson & Johnson?

Alza filed an NDA for the transdermal opioid analgesic product in December 1987 for post-operative use and for the relief of chronic cancer pain. Developed by J&J subsidiary Janssen Pharmaceutica, fentanyl has been marketed since 1968 under the Sublimaze brand. The drug is currently approved for I.V. administration and used primarily as a short-acting analgesic during anaesthesia. "This new drug delivery system will make it possible for the first time to use fentanyl . . . outside the operating room to control moderate to severe pain." Source

US opioids: Johnson and Johnson and drug distributors offer $26bn to end thousands of lawsuits. Source

The drug company Johnson & Johnson (J&J) has expressed regret after court documents unsealed in talcum powder litigation showed that it funded a 1971 study in which Pennsylvania prison inmates, most of them black, were injected subcutaneously with asbestos. Source

Asbestos Prisoner Study May Spell More Problems for Johnson & Johnson

WASHINGTON - Global health care giant Johnson & Johnson (J&J) and its subsidiaries will pay more than $2.2 billion to resolve criminal and civil liability arising from allegations relating to the prescription drugs Risperdal, Invega and Natrecor, including promotion for uses not approved as safe and effective by the Food and Drug Administration (FDA) and payment of kickbacks to physicians and to the nation’s largest long-term care pharmacy provider.  The global resolution is one of the largest health care fraud settlements in U.S. history, including criminal fines and forfeiture totaling $485 million and civil settlements with the federal government and states totaling $1.72 billion. Source

Johnson & Johnson paused all clinical trials of its experimental COVID-19 vaccine after a study participant became sick with an "unexplained illness."

Johnson & Johnson has suspended international trials of a drug in the same class as an experimental drug made by Portuguese pharmaceutical company Bial, whose tests in France left one person brain dead and five others hospitalised. Source

1982 - McNeil

Product Recalled - Tylenol (acetaminophen) capsules

Reason for Recall - Medicine laced with potassium cyanide (poison) resulting in several patient deaths.

2009 to 2011 - McNeil

Product Recalled - Several OTC medicines including Tylenol, Motrin, Benadryl, St. Joseph aspirin, Sudafed, Pepcid, Mylanta, Rolaids, Zyrtec, Zyrtec Eye Drops (tens of millions of bottles)

Reason for Recall - Unpleasant smells causing nausea; tiny metal shards in liquid medicines; wrong ingredient levels

2010 - DePuy [Pinnacle Systems]

Product Recalled - ASR Hip Resurfacing System and ASR XL Acetabular System (metal-on-metal hip implants)

Reason for Recall - Metal poisoning (metallosis); loosening of the implant or joint dislocation; additional surgeries

2012 - Ethicon

Product Recalled - Gynecare Prolift Kit, Gynecare Prolift+M Kit, Gynecare TVT Secure and Gynecare Prosima Pelvic Floor Repair System Kit (transvaginal mesh implants)

Reason for Recall - Perforation of organs; vaginal bleeding and scarring; mesh erosion; severe pain

2014 - Ethicon

Product Recalled - Power Morcellators

Reason for Recall - Spread of uterine cancer; rapid progression of the disease; death

2019 – Johnson & Johnson

Product Recalled – 33,000 bottles of Johnson’s Baby Powder

Reason for Recall – The FDA found a small amount of asbestos — a known carcinogen — in a sample

Xarelto

Number of Lawsuits - 13,511

Injuries - severe, sometimes deadly bleeding events, blood clots, wound leaks, infection

J&J was involved in seven of 2017’s top ten health-care-related verdicts.

The company was also involved in the third-largest pharmaceutical settlement with the U.S. Department of Justice. In 2013, J&J paid the Justice Department more than $2.2 billion. The settlement resolved civil and criminal allegations involving Risperdal, Invega and Natrecor.

May 2017

J&J paid $33 million to most U.S. states and the District of Columbia. The states charged J&J with misrepresenting the manufacturing practices behind certain drugs. This included its Motrin products. These products were later recalled.

Oz

[aishavass]

North America accounted for the largest share of the global transdermal drug delivery system market in 2020 and is expected to retain its position through...

[leebird-simmer]

Drug Abuse/Substance Use Disorder, pt. 2

Features of Drug Abuse & Addiction

Progression in drug use:

- Starts with a legal substance, progresses to marijuana, and then to other illegal drugs (Gateway Theory)

{Note: this is really more of a hypothesis than a theory, speaking scientifically. The only valid explanation I can give for the “gateway” idea is that buying illegal drugs requires you to seek out illegal suppliers, and often people who sell one substance will sell others. Once you develop a relationship of trust and commerce with a person, you might be more likely to try other products they have available. But this has nothing to do with the properties of THC/cannabis itself.}

- An individual who first experiments with an abused drug may or may not progress to regular, non-problematic use or beyond.

One unresolved question is why some individuals develop a pattern of compulsive drug use, whereas many others do not.

A view of pathological drug use:

Periods of preoccupation with drugs and anticipation of upcoming use.

Periods of drug intoxication, in some cases associated with “bingeing.”

Periods following drug use, characterized by withdrawal symptoms and negative affect.

There is a wide diversity of use/abstinence patterns among individuals:

Factors Promoting Addiction

Rapid effect

Positive reinforcement

Physical dependence/withdrawal syndrome

Conditioned stimuli/Associative learning

Genetics

Stress/anxiety disorders

Addictive personality

Sociocultural

Factors Suppressing Addiction

Aversive effect of drugs

Spontaneous recovery

Positive sociocultural factors

Positive reinforcement:

Drugs get you “high” (e.g. euphoria, relaxation, other good feelings)

Most abused drugs act as positive reinforcers; consuming the drugs strengthens whatever preceding behavior was performed.

Drug reward = positive experience associated with the drug.

Aversive effects:

Drugs of abuse can sometimes have aversive effects (e.g. cocaine may increase anxiety; sometimes taking hallucinogens results in a “bad trip”).

Aversive effects may not be sufficient to outweigh the many factors promoting drug use.

Speed of onset:

Addiction potential of a substance is influenced by its route of administration.

Oral or transdermal administration results in relatively slow absorption of the drug.

Intravenous (IV) injection or inhalation/smoking yields rapid drug entry into the brain and fast onset of drug action.

Fast onset is associated with:

strongest euphoric effects as a result of rapid drug delivery to the brain

shorter duration of action

higher likelihood of addiction

Negative reinforcement:

Some drugs lead to physical dependence, which may play a role in addiction.

Attempts at abstinence lead to highly unpleasant withdrawal symptoms (abstinence syndrome), which motivates the user to take the drug again.

Koob and Le Moal (2005) identified two stages in drug-taking behavior:

Impulsive stage: primary motivation is the substance’s positive reinforcing effects

Compulsive stage: primary motivation is the negative reinforcement obtained by relief from drug withdrawal

Transition from the impulsive to the compulsive stage of drug addiction

Conditioned stimuli

Pavlovian Conditioning (Ivan Pavlov, 1897):

Learning procedure whereby a neutral stimulus (such as a musical tone) comes to elicit a response because of its repeated pairing with some event (such as the delivery of food); also called classical conditioning.

Food = unconditioned stimulus (US)

Salivation = unconditioned response (UR)

Tone = conditioned stimulus (CS)

Salivation produced by a tone = conditioned response (CR)

- Over time, an addict may undergo many episodes of withdrawal.

- The responses can become classically conditioned to the stimuli associated with the environments in which withdrawal occurs.

- Withdrawal symptoms, such as craving, can then be triggered by exposure to the conditioned stimuli.

The Vietnam War & Heroin Addiction

- During the Vietnam War, around 20% of US servicemen were addicted to heroin. The US government started checking every soldier for signs of addiction before sending them home. Those who were actively using had to stay in the country until they were sober.

- Once they returned to the US, psychiatric researcher Lee Robins tracked their progress. Amazingly, only 5% relapsed (according to Lee’s research). When addicts were treated in the US, 90% relapsed. So, environment is a key factor.

Genetics

- Genetic variation may also contribute to vulnerability to addiction.

- There appear to be many genes that potentially influence susceptibility to addiction.

- Individuals who carry specific alleles of genes are at an increased risk of developing substance abuse disorders.

- In alcoholism and tobacco addiction, susceptibility genes include those coding for enzymes involved in alcohol or nicotine metabolism.

- Receptors for dopamine (in the case of alcoholism) or acetylcholine (for nicotine) have also been implicated.

Stress/Anxiety Disorders

- Stress can increase risk of addiction.

- Anxiety/mood/personality disorders are a promoting factor; when they co-occur with each other or with addiction, that’s called comorbidity.

- Self medication hypothesis: Stressful life events could trigger anxiety and mood disorders (ex. depression), which in turn could lead to substance use in an attempt to self-medicate.

Addictive Personality:

(1) Behavioral disinhibition: Substance abuse is linked to a cluster of traits - impulsivity, antisociality, unconventionality, and aggression - combined with low levels of constraint and harm avoidance.

(2) Stress reduction: High scores on traits like stress reactivity, anxiety, and neuroticism are indicative of heightened vulnerability to stress. This pathway fits with the self-medication hypothesis.

(3) Reward sensitivity: Drug abuse is related to sensation seeking, reward seeking, extraversion, and gregariousness. Individuals scoring high on these traits would seek out drugs for their positive-reinforcing qualities.

Sociocultural Influences:

When consumed in a group setting, drugs may enhance social bonds.

- Drugs can enhance solidarity within a cultural/ethnic group.

- Distinct drug subcultures; users embrace social rituals surrounding a particular drug and reject conventional social norms and lifestyles.

Many different experiences can lead to the decision to stop using drugs.

- Positive: marriage, spiritual/religious experience

- Risk of relapse reduced by such actions as moving to a new area, developing new relationships with non-users, obtaining employment, and substituting activities like physical exercise or meditation

[shrirampharmacycollege]

Shriram Pharmacy College: India’s #1 Pharmacy College Option

Welcome to Shriram Pharmacy College, a top choice for aspiring pharmacists in India. Located in Bankner, this esteemed institution offers a comprehensive curriculum designed to equip students with advanced knowledge and practical skills in the field of pharmacy. In this blog post, we’ll explore various aspects of the pharmacy program at Shriram Pharmacy College, including drug formulation methods, pharmaceutical delivery techniques, and more. Let’s dive into what makes this college the ideal option for your pharmacy education.

**Explore Drug Formulation Methods**

At Shriram Pharmacy College, students delve into diverse drug formulation methods. This aspect of the curriculum focuses on the techniques and processes involved in creating pharmaceutical products. Students learn about various formulations, such as tablets, capsules, and injectables, and the specific requirements for each. The college emphasizes the importance of precision and innovation in drug formulation to ensure efficacy and safety in medications.

**Master Pharmaceutical Delivery Techniques**

Pharmaceutical delivery techniques are critical in ensuring that medications are administered effectively. Shriram Pharmacy College provides in-depth training on various delivery methods, including oral, intravenous, and transdermal systems. Students gain practical experience in selecting the appropriate delivery technique based on the drug’s properties and the patient’s needs, optimizing therapeutic outcomes.

**Understand Drug Formulation Principles Deeply**

A solid understanding of drug formulation principles is essential for any pharmacist. At Shriram Pharmacy College, students explore the fundamental principles that govern drug formulation, such as solubility, stability, and bioavailability. The curriculum covers the scientific and practical aspects of these principles, ensuring that students can design effective and reliable pharmaceutical products.

**Study Drug Dosage Forms Thoroughly**

Drug dosage forms are varied, and mastering them is crucial for pharmacy professionals. Shriram Pharmacy College offers a comprehensive study of different dosage forms, including solid, liquid, semi-solid, and gaseous. Students learn about the preparation, characteristics, and appropriate use of each dosage form, equipping them with the knowledge needed to meet diverse patient needs.

**Research Pharmaceutical Compounding Processes**

Pharmaceutical compounding involves the preparation of personalized medications. Shriram Pharmacy College provides students with hands-on experience in pharmaceutical compounding processes. This includes creating custom formulations based on specific patient requirements and ensuring that compounded medications meet regulatory standards. The college’s state-of-the-art facilities support practical training in this critical area of pharmacy.

**Learn About Drug Delivery Systems**

Drug delivery systems play a significant role in optimizing medication effectiveness. At Shriram Pharmacy College, students study various drug delivery systems, including controlled-release and targeted delivery mechanisms. The curriculum emphasizes the design and development of advanced delivery systems to enhance therapeutic efficacy and minimize side effects.

**Focus On Pharmaceutical Technology Advancements**

The field of pharmaceutical technology is constantly evolving. Shriram Pharmacy College stays at the forefront of these advancements, incorporating the latest technological innovations into its curriculum. Students explore emerging trends and technologies, such as nanotechnology and biotechnology, which are shaping the future of pharmaceutical sciences.

**Apply Drug Formulation Theories Practically**

Applying drug formulation theories in practical settings is a key component of the pharmacy program at Shriram Pharmacy College. Students engage in laboratory work and real-world simulations to apply their theoretical knowledge. This hands-on approach ensures that graduates are well-prepared to tackle challenges in drug formulation and contribute effectively to the pharmacy field.

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**FAQs**

1. **What makes Shriram Pharmacy College stand out from other pharmacy schools?**

Shriram Pharmacy College is renowned for its cutting-edge curriculum and state-of-the-art facilities. It emphasizes practical experience and hands-on training in drug formulation and delivery techniques. The college also keeps up with the latest advancements in pharmaceutical technology, ensuring students receive a comprehensive and relevant education.

2. **What types of drug formulation methods are taught at Shriram Pharmacy College?**

Students at Shriram Pharmacy College learn various drug formulation methods, including solid, liquid, and semi-solid forms. The curriculum covers techniques for creating tablets, capsules, injectables, and other dosage forms. The focus is on ensuring the efficacy and safety of each formulation.

3. **How does Shriram Pharmacy College prepare students for pharmaceutical compounding?**

Shriram Pharmacy College provides hands-on training in pharmaceutical compounding processes. Students learn to prepare custom medications based on patient-specific needs, using modern compounding techniques and equipment. The college’s facilities support practical experience to ensure students are well-versed in compounding standards.

4. **What are the key principles of drug formulation taught at the college?**

The college covers fundamental principles such as solubility, stability, and bioavailability in drug formulation. Students learn how these principles impact the effectiveness and safety of pharmaceutical products. The curriculum ensures a deep understanding of these concepts to design reliable and effective medications.

5. **How does Shriram Pharmacy College integrate technological advancements into its program?**

Shriram Pharmacy College incorporates the latest technological advancements into its curriculum, including nanotechnology and biotechnology. Students explore these emerging technologies through coursework and practical applications, preparing them for future developments in pharmaceutical sciences.

**Conclusion**

Shriram Pharmacy College stands out as India’s premier pharmacy institution, offering a robust and forward-thinking education in pharmaceutical sciences. With a focus on advanced drug formulation methods, innovative delivery techniques, and practical applications, the college ensures that students are well-prepared for successful careers in pharmacy. If you’re looking for a top-notch pharmacy education, Shriram Pharmacy College is your ideal choice. Don’t forget to like, share, and subscribe to the Shri Ram Pharmacy College YouTube channel for more insights and updates!

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For the latest updates, educational content, and insights into the dynamic field of pharmacy, don’t miss out on the Shriram Pharmacy College YouTube channel. By liking, sharing, and subscribing, you’ll gain access to expert lectures, student testimonials, campus events, and much more. Stay informed about advancements in pharmaceutical sciences and become a part of our vibrant community. Your support helps us grow and continue providing valuable resources to students and professionals alike. Join us today and never miss an update!