#WHEN ARB WAS DELAYED... AND DELAYED......

[crehador]

the current state of the one with the clones is me whispering to clone!ichiro you have got to fuck him faster than this and him hissing back i am fucking trying?? because this 4p clone sex pwp is now

and there's still. there's still no fucking p.

[akkivee]

not that i’m particularly surprised, but hypdream has been delayed!!!! instead of releasing in the summer, we now have even more of a nondescript release date of some time in 2024!!!!!!

[fourleafclovxr]

15: delayed flight

Across from Rhian, two children begin to cry.

Kei’s eyebrows curve in concern beaide him; the children’s mother rushes to soothe them, and he shifts as if he wants to reach out, wants to help, though Rhian can’t think of any way he could. Kei has always had a soft spot for children.

They’re not the only ones in distress. The announcement went something like, this flight is being delayed twelve hours, and now they’re surrounded by clamour and complaints. Rhian pictures himself as an anchor of calm, of silence, in all this noise.

He’s kind of relieved, actually. He hadn’t particularly wanted to go home. He doesn’t, ever.

Neither had Kei, but worry twists at his mouth all the same. Rhian nudges at his shoulder in a silent question, and Kei shrugs.

“My parents will be unhappy,” he says softly. “Though I admit they would be anyway. My sisters— well. I don’t know what they’ll think. Maybe it’s just not meant to be.”

Kei speaks of his sisters often. At Arbed— when they would talk about other schools, more normal ones— they had almost seemed like a point of pride. It’s difficult to tell. For people like them, the problem children, the troubled cases, it is endlessly hard to think well of your family. They won’t ever think well of you. Even Japeth dislikes Rhian, and they’re both in the same boat, so it’s not like he has anything better to show.

But perhaps that’s just them, the Sader family. Kei talks about his sisters from a distance, more like characters than anything else. But he has never quite spoken ill of them. lt’s more that they were never afforded the chance to be close; a forced sort of isolation. Again, very much unlike Rhian and Japeth, who were stuck together, like it or not.

His parents are a different story, a more sensitive one, but so are everyone’s.

“I guess you’re happy,” Kei observes in that same, quiet way.

“Any excuse not to go home,” Rhian says. “Anything at all.” It’s a strange thing to say, in the midst of all these people who want to go home— because no one goes to Foxwood for any other reason, no one thinks of it as anything but a poorer, less exciting version of Camelot or Jaunt Jolie— but it’s the truth.

Rhian does not know what it is, to long for home. Home has always been this: absent father, obsessive mother, crazed twin. Not people Rhian wants to be defined by. Not somewhere he wants to go back to.

And sometimes it was this: inadequacy. Rhian tries— tried?— to be a good kid, to make it work, if only because he knew Japeth wouldn't. It won't ever be enough. There will always be something in him that his mother resents, even if it's only his father’s blood, his father’s face. And there will always be the fact that his father didn’t care for him, for them, that they were only an afterthought. And there will always be this family he cannot fix.

Home is too much work and not enough to gain from it, from trying. Rhian doesn’t really care to try anymore. He’s not scared. He’s not. He’s just— not willing to watch it fail.

Kei lays a hand over his. “You're in your own head again,” he says, not unkindly.

“I always am,” Rhian murmurs. Always dreaming, or, lately, the antithesis of it. Convincing himself of reality. He curls his fingers through Kei’s, and for a moment they just sit like this, holding hands at the boarding gate.

He is blessed, to have Kei, who is perhaps the only person from whom he has nothing left to hide. Rhian could not ever know how to thank him. Could not ever be grateful enough.

Kei squeezes his hand, near-gentle, and lets go. He picks up his phone from where it lies in his lap, starts typing a message. To one of his sisters, most likely. They’re lucky to be sitting next to a charging station, though they’ll probably have to give it up sooner or later. Rhian glances at his own messages— four from his mother, one from his cousin Agatha. He contemplates ignoring them.

“At least reply to Agatha,” Kei says abruptly. Rhian hadn’t realised Kei was looking over at him and his screen, close enough for their shoulders to brush. “I like Agatha.”

“Who I reply to isn’t defined by who you like,” Rhian mutters. But he clicks her message open anyway. Kei’s mouth curves into a slight smile, the only response that Rhian gets.

you’ll be here at seven tomorrow, right? Agatha has texted. my dad is worrying again.

And then there’s that. Rhian tries very hard to avoid family dinners with the previous generation of Sader siblings, which are made even more awkward for him by the fact that their entire branch of the family is technically illegitimate, and also born out of Rhian’s grandfather cheating. Going to school in a different region of the Woods has made that quite easy— for him and Agatha both, as awkward classmates, though she normally does try to go home.

This was supposed to be the first dinner he attended in a year or two. Well, that’s unfortunate. my flight got delayed, he types back. twelve hours. but mom and rj will be there at seven.

you’re KIDDING me, Agatha replies almost instantly. honestly, good for you. but good luck telling your mother. This is followed by a string of pictures of pathetic-looking animals, about ten more than Rhian asked for, or wanted. At least she didn’t say skibidi like she did the last time they texted, or he might have to block her again.

“I almost feel bad,” he mutters. “Throwing her to the wolves.”

“The good Professor will protect her from the worst of it,” Kei says lightly. “Unless your brother brings Aric, in which case there will be blood, probably. I wouldn’t put it past Aric to take a shot at Professor Sader, too. Animal that he is.”

Kei, of all of them— Rhian and his mother and Aric’s own mother and everyone else but Japeth— has always despised Aric the most. It’s been a long-standing grudge, held since Aric nearly killed Kei back in Arbed. Years have passed, now, and the scar still tugs at Kei’s lip when his mouth curls. A constant crooked flaw in his joy.

Kei, Rhian remembers, had been more angry than anything else. It had been Rhian who had worried, hands curled in Kei’s, heart in his mouth.

“If Japeth brings Aric, I’ll throw him out myself,” he says.

Kei laughs— breaks off halfway to say, “Hello, did you need something?”

Rhian stares at the kids standing in front of them. One taller girl, one tiny boy who can’t be more than five. Kei smiles, indulgent.

“Could we share the charging station?” the girl asks shyly. She holds up the phone she’s holding. “Please?”

“Of course,” Kei says, before Rhian has the chance to react. Not that he would have said no. He’s not a terrible person, just… not particularly fond of children. “You can sit there if you want?”

He gestures to the empty seats on their other side. “If your parents are alright with it.”

The two kids are already looking at their mother— and, oh, they were the ones crying. She waves an affirmation at them, exhausted, and Rhian feels a little more sympathetic. Fine. He can tolerate it, for now.

Kei tugs his charger out so that the kids can plug theirs in, chattering happily. They’re playing Candy Crush. Because of course they are. Five minutes later they lean over to ask Kei whether he knows how to play.

Kei is on level eight thousand and counting. Rhian is pretty sure he was playing earlier on. What a question to ask. What a question, indeed.

The kids are on level five hundred. Kei is practically glowing. Well, as long as he’s happy.

Rhian wouldn’t mind staying like this, he thinks, a little wistfully. Twelve hours, four more on the plane. A world to themselves. A little life of their own. A liminal space, a transition, a delay. Rhian and Kei, the way he always wants it to be.

If he’s ever longed for home, he thinks it might look something like this.

[obihiro-division]

ARB Birthday Special: Daiki Kamiyama

~ July 19th ~

“Heroes are ordinary people who make themselves extraordinary.”

Login Lines:

“The Earth has been blessed with another year of this daring hero?! What could await the great Paladin today?”

“A gift! I had predicted this would happen. Thank you! I will treasure this forever!”

Voice Lines:

“It sucks that all I got from dad is some money. What will it take for him to get it through his thick skull? I don't want his money, I want… I want to talk with him.”

“M-My brothers were a lot better at least! Akimi called to congratulate me. Same with Kenshin and Shinobu! Carter said my present was delayed since shipping stuff overseas can be a pain in the arse. Ronan said the same thing, only he told me what he got me: A metal figure of Daizyuzin from the Dinosaur Sentai Zyuranger! And Levi mailed a huge kit to build some GoGoFive models! I wanna shut myself in my room to build and track my brothers’ gifts, but I need to stay active! I have fans now that I need to thank, even if all they say is ‘Happy Birthday’!”

“Hisoka? Oh hey! I didn't expect you to- Wha? Uh, yeah, I can tell it's a gift. I'm not daft, I know it's my birthday! Okay! I'll open it!”

“Woah! Patches?! And they're the Ohsama King Ogre patches! I've never gotten something like this before! Huh? Well yeah, I love it! Don’t stress about it, I'm gonna have Jack put them on my favorite bag later! Thanks Hisoka!”

“Oh brother, here comes Jack… Nothing! Just… Excited to see you! Again.”

“A present? It better not be… Ugh, really? Cleaning supplies? I've been keeping up with my chores! I don't need... Guh…! W-Well stains are just hard to- Jack? Jack no! Not again!”

Hisoka's Lines:

“Daiki… I-I mean Dai-kun. Just… Here. It's a present. A birthday present? J-Just please open it already.”

“Y-Yeah, wasn’t really sure what to g-get you, so patches? They looked like the Sentai stuff you like, so- You really? You actually like them? And here I thought it was a shit gift. Glad you like it Dai-kun. Y-Yeah, you go ahead and do that. H-Huh? Oh, yeah, no problem o-or uh… You’re welcome. Happy birthday.”

Jack's Lines:

“Happy birthday young master Daiki…Pardon? Ahem. I see… I am glad to see you in good spirits as well, young master.”

“As per your father's request, I have come to bestow a gift. Yes, really. I have noticed your shirts are starting to suffer again, so I bought a new detergent to help deter those pesky stains... Well, I keep reminding you that you should immediately clean your clothing when you arrive home. Now come along, let's review what I showed you last week. Chop chop!”

[verdantpharma]

CAS NO 144701-48-4 (TELMISARTAN)

Understanding Telmisartan (CAS No. 144701-48-4): A Comprehensive Guide

Telmisartan, identified by its CAS number 144701-48-4, is a widely used pharmaceutical compound that belongs to the class of drugs known as angiotensin II receptor blockers (ARBs). It is primarily prescribed for the management of hypertension (high blood pressure) and for reducing cardiovascular risk in certain patient populations. Over the years, Telmisartan has gained significant clinical relevance due to its effectiveness, safety profile, and additional benefits beyond blood pressure control.

Chemical and Physical Properties

Chemical Name: 4'-[(1,4'-dimethyl-2-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid

Molecular Formula: C₃₃H₃₀N₄O₂

Molecular Weight: 514.6 g/mol

Appearance: White to slightly yellowish crystalline powder

Solubility: Practically insoluble in water, freely soluble in strong base and DMSO

Telmisartan is a non-peptide molecule, structurally engineered to effectively block angiotensin II type 1 (AT1) receptors, thereby preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II.

Mechanism of Action

Telmisartan works by selectively antagonizing the AT1 receptor, which is primarily responsible for the physiological effects of angiotensin II, such as vasoconstriction, sodium retention, and aldosterone release. By inhibiting this receptor, Telmisartan promotes vasodilation, reduces blood volume, and ultimately lowers blood pressure.

Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs like Telmisartan do not inhibit the breakdown of bradykinin, thus minimizing the risk of side effects such as persistent dry cough or angioedema.

Therapeutic Applications

1. Hypertension

Telmisartan is primarily indicated for the treatment of essential hypertension. By lowering systemic blood pressure, it reduces the risk of stroke, heart attack, and other cardiovascular events. 

2. Cardiovascular Risk Reduction

Clinical studies have shown that Telmisartan can significantly reduce the risk of myocardial infarction, stroke, or death from cardiovascular causes in patients who are unable to take ACE inhibitors. This is particularly beneficial for individuals with a history of cardiovascular disease or type 2 diabetes with target organ damage.

3. Renal Protection in Diabetes

Telmisartan has been found to delay the progression of nephropathy in type 2 diabetic patients with hypertension. It helps in preserving kidney function by reducing glomerular pressure and proteinuria.

Pharmacokinetics

Telmisartan is well absorbed orally, although its absolute bioavailability is around 42%. This extended half-life contributes to more stable blood pressure control over a 24-hour period. The drug is highly bound to plasma proteins, and it is eliminated primarily via feces with minimal renal excretion.

Safety and Side Effects

Telmisartan is generally well-tolerated. The most common side effects reported include:

Dizziness

Fatigue

Sinusitis

Diarrhea

Serious side effects are rare but can include hyperkalemia, renal impairment, and hypotension, particularly in volume-depleted patients or those with renal artery stenosis.

It is contraindicated in pregnancy due to its potential to cause injury and even death to the developing fetus when administered during the second and third trimesters.

Drug Interactions

Like other ARBs, Telmisartan may interact with:

Potassium-sparing diuretics and supplements: Increasing the risk of hyperkalemia

NSAIDs: Potentially reducing antihypertensive efficacy and impairing renal function

Lithium: May increase serum lithium levels and risk of toxicity

Patients on multiple medications should be closely monitored to avoid harmful interactions.

Advantages Over Other ARBs

Telmisartan stands out among ARBs due to several unique features:

Longest half-life among commonly used ARBs, ensuring sustained 24-hour blood pressure control

Partial PPAR-γ agonist activity, which may provide metabolic benefits such as improved insulin sensitivity

Effective cardiovascular risk reduction, as demonstrated in multiple large-scale clinical trials

These attributes make Telmisartan a favorable choice for patients with comorbid conditions such as diabetes and metabolic syndrome.

Storage and Handling

Its solid-state form is stable under normal environmental conditions, but exposure to high humidity or direct sunlight may lead to degradation. Handling of the active pharmaceutical ingredient (API) should follow standard safety procedures to minimize dust inhalation or skin contact.

Conclusion

Telmisartan (CAS No. 144701-48-4) has established itself as a highly effective and well-tolerated ARB for the management of hypertension and reduction of cardiovascular risks. Its long duration of action, renal protective effects, and potential metabolic advantages make it a versatile therapeutic agent. With a strong foundation of clinical evidence and a favorable safety profile, Telmisartan continues to be a cornerstone in the pharmacological treatment of high blood pressure and related conditions.

URL: For more information, visit Verdant Pharma : CAS NO 144701-48-4 (TELMISARTAN)

[nursingwriter]

ACE INHIBITORS vs. TIGHT GLYCEMIC CONTROL Diabetic Nephropathy Diabetic Nephropathy: ACE Inhibitors vs. Tight Glycemic Control Diabetic Nephropathy: ACE Inhibitors vs. Tight Glycemic Control Proteinuria is considered a risk factor for end-stage renal disease and coronary artery disease, secondary to diabetes (reviewed by Tan, Jaung, Gamble, & Cundy, 2014). The recommended treatment approach relies on angiotensin-converting-enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARB), with the goal of proteinuria remission and the control of hypertension. This strategy is effective for approximately 50% of type 2 diabetes patients suffering from microalbuminuria. The same treatment approach has been used for type 1 and type 2 diabetes patients suffering from macroalbuminuria and researchers have shown that remission is possible in a percentage of type 1 diabetes patients. Tight glycemic control vs. regular glycemic control were compared for efficacy in reducing the risk of cardiovascular adverse events and nephropathy in several recent large randomized-controlled trials and the results were encouraging, especially for newly diagnosed patients and long-term prognosis (reviewed by Tandon, Ali, & Narayan, 2012). These results suggest that tight glycemic control may be as effective as ACE inhibitors in achieving proteinuria remission. To better understand the relative effectiveness of the ACE inhibitors vs. tight glycemic control, a systematic review of the literature will be conducted. Medline, as accessed through the portal PubMed, and Google.com, will be the search engines used. The search strings will be "proteinuria AND tight glycemic" and "proteinuria AND ACE inhibitors." Integration and Synthesis of the Evidence Once considered a progressive and irreversible disease, diabetic nephropathy (DN) has since been shown to be amenable to aggressive treatment (reviewed by Tan, Jaung, Gamble, & Cundy, 2014). Tan and colleagues (2014) examined the effectiveness of ACE inhibitors or ARBs in achieving remission in New Zealand patients with type 2 diabetes and macroalbuminuria in a mixed-race cohort (N = 78) and discovered that remission was possible in only a third of the patients. Of the 28% who achieved remission, a relapse was observed in 27%, while another 15% experienced a gradual increase in ACR during the study period. In addition, it took an average of 30 months from peak ACR for remission to occur, with a range between 12 and 54 months. When remission did occur it lasted anywhere from 12 months to almost a decade. When macroalbuminuria was first diagnosed in this study sample, 32% of patients had no evidence of renal disease, 24% had mild to moderate nephropathy, and 44% had severe nephropathy. The generalizability of these findings is limited because of both the small sample size and how sick these patients were, but the results appear to be validated by the larger, better controlled studies discussed below. A large trial of cardiovascular patients (N = 10,251) with a mean glycated hemoglobin (HbA1c) of 8.1% were randomized to either intensive therapy to lower HbA1c below 6.0% or to standard therapy to lower HbA1c to between 7.0 and 7.9% (ACCORD Study Group, 2008). The study had to be stopped because all cause mortality for the intensive therapy group increased significantly above the standard therapy group, possibly due to an increased incidence of hypoglycemia; however, intensive group participants who survived enjoyed a reduction in cardiovascular risk several years later. In terms of DN, there was no difference between the intensive and standard therapy groups, except for a delay in onset of albuminuria and in the prevalence of macroalbuminuria (Ismail-Beigi et al., 2010). For the purposes of this review, this study is limited because it did not directly compare tight glycemic control with ACE inhibitors; however, it does reveal that tight glycemic control with a target HbA1c of 6.0% or less may be contraindicated in this patient population due to the risk of hypoglycemia. An international study investigating the relative efficacy of ACE inhibitor/diuretic with usual glucose control or intensive glucose control (HbA1c ? 6.5%) versus intensive or usual glucose control alone was conducted recently (Zoungas et al., 2009). The large cohort (N = 11,140) consisted of patients with type 2 diabetes, either with a history of major microvascular or macrovascular disease or at least one other risk factor for cardiovascular disease. The combination of ACE inhibitor and intensive glucose control reduced the prevalence of microvascular events by 19% (p = .02), when compared to intensive glucose control or ACE inhibitor alone. More specifically, all renal events declined by 28% (p < .0001), new or worsening nephropathy was reduced by 33% (p = .005), macroalbuminuria was reduced by 54% (p < 0.0001), and microalbuminuria declined by 25% (p < .001). By comparison, ACE inhibitor with usual glucose control or intensive glucose alone produced intermediate risk values between placebo and combination therapy. Based on the results of this study, tight glucose control and ACE inhibitors both provide protection against DN, but the magnitude of the effect is additive when both are combined. For the purposes of this review this is the most relevant study, but the findings would be generalizable only to patients that meet the inclusion criteria of type 2 diabetes together with major microvascular or macrovascular events. Based on the findings discussed above, both ACE inhibitors and intensive glucose control provide protection against onset or worsening of DN. The degree of success in providing reduced risk of DN or worsening DN in these studies depended on the severity of disease at the onset of the studies. In terms of safety, however, the ACCORD study revealed tight glucose control (HbA1c ? 6.0%) may not be worth the risk in patients with cardiovascular comorbidity (ACCORD Study Group, 2008). By comparison, tight glucose control (HbA1c ? 6.5%) in the ADVANCE study did not increase the risk of all cause mortality, and when combined with an ACE inhibitor/diuretic actually reduced mortality significantly (p = .04). The patient populations between the ACCORD and ADVANCE studies differed, because in the former they all had cardiovascular disease, whereas in the latter all had diabetes with or without cardiovascular disease. Based on this evidence alone, a combination of ACE inhibitors and tight glycemic control would be indicated for all diabetes patients at risk for developing microvascular events, including DN; however, tight glucose control with a target HbA1c level of 6.0% or less may be contraindicated for cardiovascular patients due to the increased risk of hypoglycemia and all cause mortality. Comparative Evaluation of the Evidence to Practice The use of both ACE inhibitors and tight glycemic control for preventing or controlling proteinuria associated with type 2 diabetes is essentially non-existent in my clinic; however, a diagnosis of type 2 diabetes triggers a test for albuminuria, which is repeated annually. Even if a diabetes patient with microalbuminuria is normotensive, they are given an ACE inhibitor or ARB to slow progression to macroalbuminuria. By comparison, tight control of hyperglycemia to an HbA1c level at or below 6.0% is simply not routine nor recommended for patients. In my clinic, we consider any HbA1c level below 9.0% better and below 8.0% best, depending on the disease severity and prognosis. There is thus a wide margin between what some research groups define as tight glucose control and what is considered tight glucose control in my clinic. If my clinic were to adopt tight glucose control as best practice, with a target HbA1c level somewhere between 6.5 and 7.0%, there would be significant barriers to change. From the perspective of patients, taking multiple drugs with a risk of side effects, including drug interactions, would tend to increase the risk of noncompliance. Based on my experience, patients also tend to lack sufficient diabetes knowledge to increase their treatment self-efficacy, including making the necessary lifestyle changes and complying with aggressive treatment recommendations. From the clinician perspective, there would be some resistant to the increased time burden required to fully evaluate and follow patients who are being treated using tight glycemic control, let alone deciphering the conflicting guidelines that have been published (reviewed by Bailey, 2013). Other clinician-associated barriers would include the lack of financial incentives, practice inertia, and resistance to prescribing multiple drugs for patients. Of all the barriers to implementing combination therapy with an HbA1c target below 7.0%, probably the most significant is a lack of consensus. Without agreement between the government and non-profit stakeholders the implementation of combination therapy based on tight glycemic control to prevent or control DN will not be feasible. Summary The evidence supporting the efficacy of tight glycemic control for controlling and preventing DN is growing with each passing year. The current state of research suggests that the primary benefit of tight glycemic control, with an HbA1c target below 7.0%, may not be realized until years later. While this finding is indeed promising, current best practice for treating DN is standard glycemic control in combination with ACE inhibitors or ARBs. The HbA1c target, however, is typically based on local guidelines and therefore remains controversial. Most patients would benefit from this conservative approach, so the main question raised by the research presented here is "how low should the HbA1c target be and for which patients?" References ACCORD (Action to Control Cardiovascular Risk in Diabetes) Study Group. (2008). Effects of intensive glucose lowering in type 2 diabetes. New England Journal of Medicine, 358(24), 2545-59.  https://www.paperdue.com/customer/paper/poorly-controlled-type-ii-diabetes-mellitus-183087#:~:text=Logout-,PoorlyControlledTypeIIDiabetesMellitus,-Length5pages Bailey, T. (2013). Options for combination therapy in type 2 diabetes: Comparison of the ADA/EASD Position Statement and AACE/ACE Algorithm. American Journal of Medicine, 126, S10-S20. Ismail-Beigi, F., Craven, T., Banerji, M.A., Basile, J., Calles, J., Cohen, R.M. et al. (2010). Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: An analysis of the ACCORD randomized trial. Lancet, 376(9739), 419-30. Tan, J., Jaung, R., Gamble, G., & Cundy, T. (2014). Proteinuric renal disease in type 2 diabetes: Is remission of proteinuria associated with improved mortality and morbidity? Diabetes Research and Clinical Practice, 103, 63-70. Tandon, N., Ali, M.K., & Narayan, K.M. (2012). Pharmacologic prevention of microvascular and macrovascular complications in diabetes mellitus: Implications of the results of recent clinical trials in type 2 diabetes. American Journal of Cardiovascular Drugs, 12(1), 7-22. Whittemore, R., Melkus, G., Wagner, J., Northrup, V., Dziura, J., & Grey, M. (2009). Translating the Diabetes Prevention Program to primary care: A pilot study. Nursing Research, 58(1), 2-12. Zoungas, S., de Galan, B.E., Ninomiya, T., Grobbee, D., Hamet, P., Heller, S. et al. (2009). Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial. Diabetes Care, 32(11), 2068-74. Read the full article

[molygraph-blog1]

Super Lubricating Abilities for The Steel Industry

Lubrication is a crucial element required for any moving machine and its parts. Without lubricants, the life-expectancy and efficient functioning of any rotating equipment is greatly reduced. Productivity is delayed due to premature bearing failures, increased use of energy, and machine downtime. This leads to further losses of production which calls for new and improved lubrication solutions.

When lubricants are used in machines, their main functions are to:

Transport contaminated particles to filters and maintain cleanliness

Create a film between metal surfaces to reduce friction

Protect metal parts from corrosion

Cool surfaces by dissipating heat

The steel manufacturing industry involves processes that are exposed to high temperatures, extreme loads, and corrosive and humid environments. These factors influence the way lubricants work on machines, creating more demand for super lubricating abilities.

Molygraph’s speciality lubricants have, therefore, been developed to offer several benefits to clients. Our diverse and complete range of lubricant solutions helps in managing critical steel manufacturing processes. The cost of maintenance is reduced as productivity is improved through quality lubrication. Our products are environment-friendly, making them a safe and protective fit for operators.

Molygraph’s Customised Range of Speciality Lubricants

We have developed three versatile lubrication applications for the steel industry, namely:

Integrated Steel Plant

Steel Pelletizing Plant

Sponge Iron Plant

1. Integrated Steel Plant

Our lubrication products cover a wide range of areas at integrated steel plants. We aim to help reduce costs by enhancing productivity regardless of any extreme environmental conditions. From ironmaking to finished products, lubrication solutions are, thus, developed to meet all requirements at Integrated Steel Plants.

The application components shown below are based on the areas our products can be used.

Raw Material Preparations: Storage

Raw Material Processing: Coke Oven Plant, Lime Plant, Sinter Plant

Pig Iron Production: Blast Furnace

Caster: Continuous Caster

Hot Rolling Mill: Work/Back-Up Roll Bearings, Chokes Window Liner, Rolling Mill Drive Shaft Gear Couplings, and Re-Heating Furnace Table Roll Bearing

Cold Rolling Mill: Work/Back-Up Roll Bearings, Roll Chokes Liner, Rolling Mill Drive Shaft, Gear Couplings, Pickling Line, Squeezer Roll Bearing, Water Rinse Tank Bearing, Wringer Roll Bearing, Arb Blower Fan Bearing

Bar and Rod Mill: Reheating Furnace Withdrawal/Roll Table Bearing, Work/Back-Up Roll Bearing, Roll Chokes Liner, and Rolling Mill Drive Shaft Gear Couplings

2. Steel Pelletizing Plant

The process of pelletizing iron involves converting iron ore fines into uniformly sized iron pellets. These pellets are then charged directly into the blast furnace. Our lubricating range of products is designed to meet the challenging and demanding processes involved in the Steel Pelletizing Plant.

The application components involved in the following processes are:

Grinding Mill: Ball Mill Girth Gear, Ball Mill Girth Gear Pinion Bearing

Mixture Machine: Mixture Machine Bearing, Mixture Machine Gear

Balling Disc: Balling Disc Girth Gear, Balling Disc Bearing

Travelling Guide: TG Plumber Block Bearing

Kiln: Kiln Girth Gear – Spray System, Support Roller Bearing/Kiln, Thrust Bearing/Bucket, Elevator Bearing, Sliding Surface of Track

3. Sponge Iron Plant

Sponge iron is produced from the direct reduction of iron ore, and it can be further processed into wrought iron. It is useful as feedstock for speciality steel manufacturers. The lubricants in this process are required to be thermally and mechanically stable. It should also be able to resist water washouts.

Our range of lubricants covers the entire spectrum of applications including Kiln & Cooler Slip Seal, Kiln & Cooler Girth Gear, Support Roller Bearing, Vibrator Screen Bearing, Id/Fd Fan Bearing, and so much more. You can know more about the Sponge Iron Plant on our website.

Are you prepared to take your steel manufacturing processes to the next level? We have a Field Engineering Services Team ready to support, guide you and provide end-to-end lubrication education. Get the best deals in lubrication for steel with Molygraph.

[iebpharma1]

How Does Barigen 4 mg Work?

Barigen 4 mg is a medication that is commonly used to manage various health conditions, primarily related to hypertension (high blood pressure) and certain heart-related issues. It is also effective in helping to reduce the risk of complications such as stroke, heart attack, and kidney problems by controlling blood pressure. This pharmaceutical product is part of a larger family of medications known as angiotensin II receptor antagonists or ARBs.

What is Barigen 4 mg?

Barigen 4 mg is primarily used to treat high blood pressure (hypertension) and can be prescribed to both adults and children, depending on the medical situation. The active ingredient in Barigen is Irbesartan, a potent ARB that works by blocking the action of a substance in the body called angiotensin II. Angiotensin II is responsible for narrowing blood vessels, which increases blood pressure. By blocking this substance, Irbesartan helps to relax and widen the blood vessels, thereby lowering blood pressure and improving blood flow.

How Does Barigen 4 mg Work?

The effectiveness of Barigen 4 mg (Baricitinib) lies in its ability to interfere with the effects of angiotensin II. Angiotensin II is produced in the body when the kidneys release the enzyme renin in response to a drop in blood pressure or sodium levels. This hormone constricts blood vessels, resulting in an increase in blood pressure. Irbesartan, the active ingredient in Barigen, binds to the angiotensin II receptor and prevents the hormone from exerting its narrowing effect on blood vessels. This helps to reduce blood pressure, improve circulation, and, in the long term, prevent damage to organs like the heart, kidneys, and brain.

Primary Uses of Barigen 4 mg

Hypertension (High Blood Pressure): Barigen 4 mg is mainly prescribed for treating hypertension, a condition in which blood pressure is consistently higher than normal. If left untreated, high blood pressure can lead to serious health problems such as heart disease, stroke, kidney failure, and even damage to the brain. By managing high blood pressure, Barigen helps prevent these complications.

Chronic Kidney Disease (CKD): In patients with kidney problems, especially those who have diabetes or hypertension, Barigen 4 mg may be used to protect kidney function. By controlling blood pressure, this medication reduces the strain on kidneys and can help delay the progression of kidney damage.

Heart Failure: Barigen may also be beneficial for patients with heart failure. In this case, its ability to reduce blood pressure and improve blood flow can relieve the heart’s workload, allowing it to pump blood more effectively.

Diabetic Nephropathy: Barigen 4 mg is also prescribed for patients with diabetic nephropathy, a kidney disease that is commonly caused by diabetes. This condition can lead to kidney damage, and by controlling blood pressure, Barigen can help slow the disease’s progression.

Dosage and Administration

Barigen 4 mg is generally taken once a day, either with or without food, as directed by a healthcare provider. The dosage may vary based on the patient’s medical condition, response to treatment, and other factors such as age and kidney function. It’s important to follow the prescribed dosage schedule and not to exceed the recommended dose, as this could lead to adverse effects.

For those who are starting on Barigen, healthcare providers may begin with a lower dose and gradually increase it depending on the individual’s response. Regular monitoring of blood pressure and kidney function is essential to ensure the medication is working effectively and to avoid potential complications.

Side Effects and Safety Information

While Barigen is generally well-tolerated, like any medication, it can have side effects. Some common side effects include dizziness, fatigue, and headaches, especially when standing up quickly. These effects usually subside as the body adjusts to the medication.

Serious side effects, although rare, may include:

Low blood pressure (hypotension)

Elevated potassium levels (hyperkalemia)

Kidney dysfunction

Patients who experience any signs of an allergic reaction, such as swelling of the face, lips, or tongue, should seek immediate medical attention.

Trust and Availability

Barigen 4 mg is available worldwide and is trusted by healthcare professionals for managing blood pressure and kidney function. At our global pharmacy, we ensure that all medications, including Barigen, are sourced from reputable manufacturers and are thoroughly tested for quality and efficacy. We provide our medicine services with the utmost trust and reliability, ensuring that patients across the world have access to the medications they need to manage their health effectively.

Our commitment is to deliver genuine medicines with a focus on patient well-being. We guarantee 100% trust in our services, providing medications that are safe, reliable, and accessible. Whether you’re in need of regular prescriptions or a one-time order, our global delivery system ensures that you receive your medicines promptly and securely, no matter where you are.

Conclusion

Barigen 4 mg is an effective solution for managing hypertension, protecting kidney function, and treating heart failure. Its active ingredient, Irbesartan, works by blocking the action of angiotensin II, leading to the relaxation of blood vessels and a reduction in blood pressure. With its wide-ranging benefits, Barigen is an essential medication for those at risk of serious cardiovascular and kidney complications. When using Barigen, patients can trust that they are receiving a high-quality, effective treatment designed to improve long-term health outcomes.

[arbvehiclerecovery]

Road Assistance London

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[ailtrahq]

This is an opinion editorial by Daniel Hinton, the head of finance and operations for sFOX, a bitcoin prime broker and custodian, and Steve Jeffress, creator of Bitcoin UTXO set visualizer UTXO.live.We now know how to infer the daily price of bitcoin within 1% by looking only at the unspent transaction output (UTXO) set.With this, we can build decentralized applications that rely on the UTXO set — rather than on trusted third-party oracles — for the USD price used in discreet log contracts (DLCs) and smart contracts.The possibilities for decentralized applications on Bitcoin using this “UTXOracle” are enormous. Source: author When You Want To Know ‘The’ Price Of Bitcoin, Where Do You Look?There is no single price of bitcoin. Every second of the day, there are thousands of exchanges, brokers, OTC desks, payment companies and other market participants around the world quoting the price of bitcoin — and none of them is always correct.In this article, we will explore a new way of interpreting the Bitcoin UTXO set that accurately reflects a bitcoin price at each block height and has the potential to serve as the foundation for a new era of trust-minimized, decentralized finance on Bitcoin.What trust-minimized tools could you build if you could calculate an accurate price for bitcoin at each block height, using only your Bitcoin full node and an open-source model?DLC derivatives (options, futures, perpetual futures)On-chain lending marketsPeer-to-peer marketplacesBitcoin-backed USD stablecoins on LightningStable-value USD accounts denominated in bitcoinAny use case that requires a USD componentAny one of these concepts, successfully implemented on the Bitcoin blockchain in a trust-minimized way, could deliver tremendous value to both Bitcoiners — utilizing bitcoin for its superior monetary properties — and participants in the Bitcoin ecosystem who need to remain partially tied to USD but want to utilize Bitcoin as their settlement network.On-Chain Transactions Encapsulate The Global Signal Of Economic WeightDuring the 2016 to 2017 “Blocksize Wars,” the merits of not only running a fully-validating Bitcoin node, but conducting economic activity using your node, were convincingly argued in helping the network avoid a meaningful fork that could have delayed Bitcoin’s success.For purposes of our current discussion, it can be said that this tumultuous time in Bitcoin’s history emphasized that, in the same way that someone can run 1 million “full nodes” on a cloud server that signal for a particular “upgrade” but not influence the network of economic actors in any way if they are not actively settling transactions, centralized exchanges can produce volume and price statistics that, in reality, do not carry economic weight, and which are not reflected in the UTXOs that are settled onto the Bitcoin blockchain.You can temporarily give the appearance of having more bitcoin than you do within a closed system like an exchange, but as long as there is a credible threat of withdrawal for settlement to the Bitcoin base layer, any mispricing within the closed system will eventually resolve itself back to equilibrium with the external market.For example, when Mt. Gox was insolvent in 2013 to 2014, but before it officially collapsed, the reported price of bitcoin on the platform was markedly different from other exchanges due to the fact that Mt. Gox did not have nearly as much bitcoin as it claimed. As a result, it needed to entice new users to deposit to the exchange in order to fulfill withdrawals from existing customers. Within the Mt. Gox system, the price could be manipulated, but when users attempted to arbitrage the price back to the market, Mt. Gox collapsed.In contrast, the Bitcoin blockchain is the hardest ledger in the world to corrupt. It represents the entire history of economic settlement activity to have occurred and is the final arbiter of truth with regard to the status of all bitcoin in existence.Transactions that matter are settled on the Bitcoin blockchain, not in closed systems.

Final settlement is what matters.UTXOs Are Created And Destroyed Each Time You Move BitcoinPeople have a difficult time grasping Bitcoin, since it’s impossible for them to take a physical coin out of their pocket, point to it, and say, “This is a bitcoin.” One analogy I’ve gravitated toward when describing a specific amount of bitcoin in a person’s possession is visualizing an individual bill in a physical wallet. These bills can represent any amount and are only good for one use. So, if you need to spend $3, and only have a $100 bill, you can’t rip off a corner of the bill. You would need to spend the entire $100 bill and get your change back. In Bitcoin parlance, each of these bills is a UTXO. Any time you send bitcoin, you are spending (and destroying) at least one UTXO while simultaneously creating at least one new one. If you run any version of the Bitcoin software, at any point in time you can count up all the bitcoin contained in existing UTXOs to determine exactly how much bitcoin currently exists.In fact, when used together, the Bitcoin blockchain and UTXO set are perfectly accurate in determining the history and current state of the Bitcoin network. This never-before-seen capability in a decentralized system helped the 19 million bitcoin currently in existence grow to be worth several hundred billion dollars.The Bitcoin software uses units of bitcoin (satoshis) for its internal accounting. While it may be obvious that 1 bitcoin equals 1 bitcoin, this also means that when someone wants to “send $100 of bitcoin,” the participants in this transaction need to agree on the price of bitcoin at the time of the transaction to know how much bitcoin this corresponds to.On Average, 15% Of All Bitcoin Transactions Are In Round USD ValuesDid you know that many people transact bitcoin in round USD amounts? Interestingly, because this is such a common occurrence, there are clearly-recognizable patterns that exist in the UTXO set that can be used to closely infer the price of bitcoin at any point in the past or present (see the chart below).Imagine that you are buying bitcoin at an ATM (or buying a gift card online). Will you buy $100 worth or $39.27 worth?Round USD values ranging from $1 up to several thousand dollars are very common denominations in the Bitcoin blockchain. In fact, since 2014, there has been a growing on-chain footprint of these round-USD-value bitcoin transactions which on some days can account for up to 25% of daily outputs created.The United States has by far the largest installed base of Bitcoin ATMs globally. U.S. Bitcoin ATM operators have grown dramatically since 2019 and the Bitcoin UTXO set vividly displays this market’s growth as more people choose to hold or at least transact in bitcoin over USD.Also, as seen with clients at sFOX, Bitcoin ATM flows are made of nearly all customer buys (putting cash into an ATM and receiving bitcoin), so the on-chain footprint of this activity consolidates signals at round USD values. Other large bitcoin markets, such as gift cards, peer-to-peer exchanges, and many other, less common use cases, also contribute to this pattern of USD-denominated bitcoin usage.The Bitcoin UTXO Set As Of Block 772,298There is only one bitcoin UTXO set at any given block height. This picture depicts the entire, approximately 70 million UTXOs that comprise all 19 million bitcoin in existence, as of block 772,298.With Bitcoin being truly permissionless, anyone running a fully-validating Bitcoin node has this exact same data on their computer and can independently replicate this exact same dataset for this point in time. A live version of this visualization can be seen and interacted with at utxo.live. Source Zooming into the 2022 section of the chart highlights that there are consistent patterns in the UTXO set. We’ll focus on two such patterns: Horizontal lines and wavy lines. Source Horizontal lines (the flat lines) represent:UTXOs denominated in round values of bitcoin (e.

g., 0.001, 0.005, 0.01, 1, etc.)Flat at any USD price because sending 1 btc always equals 1 btcWavy lines: Represent groupings of UTXOs denominated in round USD values ($1, $20, $50, $100, $200, $500, $1,000, etc.)Are very wavy, yet parallel to each other because people send in many USD denominations and these denominations all move in proportion to each other as the BTC/USD price changesMove inversely to price. BTC/USD price increases cause the wavy lines to slope down since it takes less BTC to equal a USD value as price moves up and vice versa.Making Sense Of The LinesThe fact that horizontal lines exist isn’t all that impressive. People transacting in bitcoin often transact in round amounts of bitcoin.But the fact that the wavy lines exist clearly and consistently is a big deal. It means that, given an open-source model, this could help bring about the ability to:Independently calculate the price of bitcoin using only your full node at any block heightDevelop genuine DeFi applications without the need for (or without sole reliance upon) trusted third-party price oraclesThe UTXOracle Price Model Has Native Logic ChecksHow can you easily test the hypothesis that the wavy lines represent movement of bitcoin denominated in USD? Simply pick a date when you know the BTC/USD price crossed a round USD value and see if the horizontal and wavy lines cross.One such case is July 27, 2020. Bitcoin was recovering from the March 2020 mayhem and crossed over $10,000 per BTC.The image below shows the wavy line (USD) crossing down below the horizontal line (BTC) at the same time that the price rose above $10,000 per BTC. This particular image is the 10,000 sat (0.0001 BTC) line, but the same pattern exists at many other BTC denominations as you progress up the UTXO chart. On July 27, 2020, the bitcoin price increased past $10,000. Source. Still don’t see it? Zoom in and explore a high-resolution image at utxo.live. Mr. Pitt from “Seinfeld,” “I don’t see it.” Source. Clearly, the wavy lines on the chart show transactions denominated in USD.This has enormous ramifications, since the wavy line pattern exists in varying degrees in every block, and is extremely consistent over rolling periods such as every 144 blocks (roughly 24 hours).The UTXOracle USD Bitcoin Price Is Quite AccurateSeeing the horizontal and variable lines cross at round USD values is nice, but a majority of the time, the lines are not very close to one another. We need a way to prime a pricing model from these crossing points that will infer an accurate, current price at any block height after the model is primed.Enter the UTXOracle model.In this preliminary model, an input date of July 27, 2020, a day when bitcoin rose above $10,000, is used to prime the model to a best fit for that day’s price. Using only this single day’s UTXOs, and an input of that single day’s volume-weighted average price (VWAP), we are able to create a model that, when used with a future date’s UTXO set changes, infers the daily price of bitcoin with remarkable accuracy from this day forward, utilizing only the Bitcoin UTXO set with no reference to any external price data after July 27, 2020.The red line is the daily VWAP from sFOX, an aggregator whose price encompasses the filled trades from dozens of exchanges and OTC desks.The blue line is the UTXOracle daily price calculation based on each day’s UTXO changes. Source: author For the measurement period of July 2020 to January 2023, the model performs exceptionally well, with daily median and daily average variances between the actual VWAP and the UTXOracle price of 0.65% and 1.04%, respectively, both of which are within the normal range of fees charged for bitcoin purchases at retail exchanges.It’s been said that all models are wrong, but some models are useful. One key difference between the UTXOracle model and other models that output a bitcoin price is that the UTXOracle model does not seek to predict a future price.

It merely attempts to infer an accurate current price based on recent blocks and corresponding changes in the UTXO set. Given that the current model has also not been fine tuned for a best fit and simply uses a single primer date for its input, the model is clearly wrong — hopefully it can be useful.The UTXOracle Model Has Trade-OffsIf Bitcoin has taught me anything, it’s that trade-offs exist. The UTXOracle model is no different.The Bitcoin UTXO set is a beautiful, living monument to the human spirit but try as we may, any model created from it will not fully encapsulate the entirety of the underlying activity which it represents. A map cannot be as accurate as the territory it represents.The UTXOracle model relies on several concepts to function correctly:Bitcoin UTXO data (free and widely-available data accessed by running a full node)Bitcoin price data to identify a time or series of times upon which to prime the model (based on free and widely-available data)A model to apply the primer date(s) generally to any date (there are many ways to optimize this)A way for users of the UTXOracle output price to utilize the price in DeFi applications (this needs significant effort to develop)People may create UTXOs at amounts that would mimic the price being another level than reality.On centralized venues, people have been known to “spoof” large buy or sell orders in an order book to make it seem as though there is a large buyer or seller in the market, only to later remove these buy/sell orders without actually having any trades filled. This can actually move markets on centralized venues, but you cannot spoof UTXOs. They either exist in a mined block or they do not.It takes a long time to create a fake price signal and it’s obvious when someone tries to do so.Currently, it looks as though using a daily UTXOracle signal, rather than a single block interval, achieves a price accurate enough to use in practice. This approach has the added benefit of greatly increasing the cost of attack in mimicking or censoring transactions which would be most useful in producing the UTXOracle price at any certain time.Even if someone created many UTXOs at levels mimicking a different bitcoin price, there is no mechanism to remove the real transactions that reflect the accurate price. At best, an attacker would create an additional set of wavy lines.UTXOs are expensive to fake. There is no such thing as “spam” in the Bitcoin blockchain. There are only transactions that pay a fee to be included in a block. This means that blockchain data is expensive to produce or censor and there is a real cost of capital in creating UTXOs to fake a price signal.Current model accuracy diminishes after about two years, as is visible in the chart. In practice, it’s likely that a model will need to be recalibrated after some period of time. Changing the model to take into account different UTXO patterns carries much less risk than changing consensus rules in Bitcoin. Unless participants are transacting in multi-year options/futures contracts on chain, this is likely not a meaningful barrier to use.The current model does not deal with extreme volatility well. Mempool variations and price volatility create situations where the UTXOracle price can temporarily vary from the centralized exchange price by more than 10%. While this can likely be improved upon with a more comprehensive model it does highlight a potential serious limitation of the practical use of the model. Then there is the AI echo chamber problem: If the model is very successful, it may become less effective. In a world where many people are settling economic activity using the price inferred by a UTXOracle model, there will be many additional UTXOs settled in round USD values. These UTXOs may diminish the model’s accuracy or distort it in other ways similar to how a large-language model (LLM) trained on LLM-generated content will not match the effectiveness of one trained on human-generated content.Using A UTXOracle Model In PracticeLove it or hate it, you know the word “Ordinal.

” Ordinals taught me that people can coalesce around a methodology of interpreting the UTXO set that is technically external to Bitcoin, but which can be solidified at the social layer as an additional protocol on top of Bitcoin.It is my hope that a sufficiently-accurate UTXOracle model will be produced by someone which will allow people to use that version of the model as a schelling point in building decentralized applications on Bitcoin.It is my further hope that Bitcoiners can develop a method of using these one or more competing models in a trust-minimized way to expand how Bitcoin is able to bring financial peace to the world.A successful implementation would be one in which:Model inputs are publicly known and outcomes are verifiableDLC participants can contest fraudulent outcomes by calculating their own price using the model inputs. (An elegant solution to this issue remains an unsolved challenge.)And one in which any of these security models is possible: Peer to peer: Two or more ordinary participants can utilize the UTXOracle model without third partiesVerifiable, centralized oracle attestations: A centralized oracle signs a message with a particular UTXOracle pricing model that the oracle will use and participants are able to verify outcomes and punish wrongdoingUTXOracle as a quorum member: Use the UTXOracle price as a logic check in a traditional, centralized oracle model or in a two-of-three or three-of-five multi-oracle setupUTXOracle Use CasesDLC Derivatives (Options, Futures, Perpetual Futures)This would enable users to buy or sell contracts in an open marketplace where outcomes are administered by participants using a UTXOracle price.For example: Alice deposits an amount of bitcoin to a DLC-governed address. Bob pays Alice an amount of bitcoin denominated in USD (as evidenced by the UTXOracle price). At the time of settlement, Alice or Bob may produce a signature from an oracle attesting to the price calculated under the UTXOracle model to determine the settlement flow of funds as expired or exercised.On-Chain Lending MarketsUsers can borrow or lend in an open marketplace where the loan life cycle is administered by participants using a UTXOracle price.For example: I have 1 BTC (at a $100,000 value) and want to take a partial loan of $30,000 without selling my bitcoin. I can coordinate with a market-maker to deposit my 1 BTC and the market maker’s 0.3 BTC (at a value of $30,000) to an address governed by a DLC. Upon funding, I may spend the 0.3 BTC for my desired use case.Normal Loan RepaymentIn this use case, the borrower has the option to sign a transaction granting the market maker $30,000 in value of the original 1 BTC or to deposit $30,000 in value (as evidenced by the UTXOracle price) and withdraw the original 1 BTC.Upon liquidation, if the value of the 1 BTC in the DLC-governed address falls to somewhere near $30,000 (as evidenced by the UTXOracle price), the market maker can sweep out the entire 1 BTC to liquidate the loan and recoup their principal.StableSats The UTXOracle model also offers an interesting use case around “stablesats,” referring to bitcoin-backed USD stablecoins or stable-value USD accounts denominated in bitcoin on Lightning.For instance, imagine that you want to hold $1,000 worth of bitcoin for the next month. You do not want to or cannot hold the $1,000 in cash, at a bank, in Ethereum- or Tron-based stablecoins or on an exchange. You could enter into an agreement with a market maker on the Lightning Network to stream the daily net price change in value to you. You would be able to independently validate that the correct amounts are being paid by using the UTXOracle model you agreed to. At the end of the month you will have a different amount of bitcoin in your Lightning channel, but it will be worth $1,000.Peer-To-Peer MarketplacesAs a seller in an online marketplace, it’s currently difficult to price items in bitcoin due to the volatility as well as the fact that your expenses are likely in USD.

But accepting payments in USD means accepting chargeback risk, fraud and the fees and complexity inherent in modern payment systems. Pricing products in USD, but having the flexibility to accept a USD value in bitcoin via the UTXOracle model, could encourage more bitcoin-denominated commerce.The Next Steps For UTXOracleAs outlined in this article, I believe the UTXOracle model could be a powerful tool in advancing Bitcoin use cases and extending financial freedom to more of the world. While it has trade-offs, I believe it represents an exciting frontier that can improve upon existing solutions that require more trust in third parties.If you are excited about the prospect of UTXOracle, I encourage you to join the discussion on Telegram and Twitter.This is a guest post by Daniel Hinton and Steve Jeffress. Opinions expressed are entirely their own and do not necessarily reflect those of BTC Inc or Bitcoin Magazine. Source

[kobayashi-aika]

Aqours 4th Live ~Sailing to the Sunshine~ Pamphlet: Kobayashi Aika

This pamphlet originally came out before 4th live, but the only source images we had to work with were phone camera photos. Now they’re fully scanned in hi-res (minus Tumblr compression) glory. Delayed viewings for this live will start this weekend, so if you have the time and money, please go to support Aqours!

Thanks to Arishamod for the pamphlet scans.

Aqours’ dreams have just begun.

Since we’re in Tokyo Dome, we’ll make the future and these dreams reach everyone!

The devil’s kiss— it’s a magic spell that will always make your heart throb!

I’ll trap you in the unending hell of loving Yohane!

What I want to get across to you, member number 10, is “thank you” and “I love you” ❤❤

Aqours’ tenth member, everyone out there, is really important to us, and this theme song put me in tears. Just like we sing in the song, we’ll treasure these important bonds and keep moving forward—

#1: The venue this time will be Tokyo Dome! Any impressions or memories?

In short, it’s the stage I’ve always dreamed of. It’s a stage where not just Japanese artists, but artists from around the world come to perform at. I’ve been there many times to go watch concerts. I’m so happy that I have the chance to stand on that stage. I want to treasure every moment, and get my feelings of gratitude across to everyone. Because I was with Aqours, and I was with Yohane, I was able to work hard to make it here, and we’ll keep on doing that. Please watch us.

#2: Aqours’ hometown is Numazu⭐ Once again, what kind of place is it?

The best part about Numazu is the sea, the mountains, the people, and everything! I go there on my own time, and I’ve taken my family around to see all the places in the city. It’s a wonderful place that I want everyone around me to know about. That’s why I want to let more people know how wonderful Numazu is. I’ll keep doing my best as part of Aqours to make that happen!

#3: Tell us about a memory or story you have from Numazu!

This is a story from when I went there last year for Yohane’s birthday. There was a huge rainstorm, so it felt like Yohane was bringing her bad luck upon Numazu, as if she was really there. (laughs) Because of that, I came to love Yohane even more. It felt like I was going around Numazu together with her, and it made me really happy. It was a wonderful day ♪

#4: If you had to give Yoshiko a surprise present, what would you do?

If I had to give her a present… I can think of a lot of things, but I don’t know if she would be surprised by just that. So, with these feelings of “thank you” and “let’s be together from now on, too” in mind, I’ll cover all of Tokyo Dome in her white color! I hope she can see it soon!

To you, the tenth member of Aqours,

Yohane and I can sing like this because we met all of you!

Yohane and I are having fun because you’re here!

Yohane and I can be strong because you give us all your love and support!

Yohane and I always have you in our hearts And you give us a push— sometimes gently, sometimes strongly.

“Thank you, FRIENDS!!”

We have you. And you have us.

There’s nothing to fear. We’ll go forward together. From now on and forever! ❤❤

From Kobayashi Aika and Tsushima Yoshiko, with love.

Sorry for the slowdown in translation work; school and other projects have taken up most of my free time. -arb

[step2ckmap]

Diastolic murmur= Diuretic (Mitral stenosis, Atrial regurg)

Aortic Stenosis:

Ejection systolic murmur at right upper sternal border

Soft single S2 (loss of splitting during inspiration,“Paradoxical”)

Delayed and diminished carotid pulse (Parvus et Tardus)

Loud and late peaking systolic murmur

Diuretics best initial, will not alter long term prognosis

Onset of symptoms gives mortality of 50% at 3 years. Repair if symptoms, decreases mortality.

Repair if: Jet velocity >4m/s, valve pressure gradient >40, Valve area <1cm2

Anatomic repair (bovine last 10y, mechanical longer but need AC)

Aortic Regurgitation:

Diastolic decrescendo at left sternal border

Increase: Leg raise, squatting, hand grip

Waterhammer pulse, quinke pulse in fingernails, BP gradient in LE higher

ACEi, ARB, and Nifedipine best initial

Can also add loop diuretic

Surgery when EF <55% or LV end systolic diameter >55mm. Even if no sympt.

[lisa-in-the-sky]

Bar/Restaurant x Space AU.

Hi, I just sent you one of those trope mash ups and, clever me, didn’t put a ship in there. Sooo… Sam Wilson x dealers choice?

I….got a little carried away.

send me two tropes

It turned out it doesn’t matter what planet you’re on or from, being in customer service fucking sucked. Everywhere. Sam found that out about three days into first job in Ychyn when a Fe’ali wiggled it’s eyebrows (Sam wasn’t actually sure he should use that word for a creature whose face looked like the mangled remains of a blown tire) at him and then hit on him with some truly horrifying pick up lines before puking all over the bar and having to be dragged out by security. The section of the bar could be replaced, but Sam was never gonna forget the smell.

Unfortunately, his intergalactic trip had pretty much sucked him dry financially, and it turned out that once you landed in an alien metropolitan mecca, opportunities and cash for getting out were slim.

Sam had been working at Sin Sin’s Leopard Lounge for three Earth years, four months, 27 days, and he was sure of two things. First, he’d never stop smelling like tebholhy - bright orange space booze that Sam refused to let near his mouth after an incident involving two Arb girls and a hoverbike left him sore and voiceless for a week - and second, his only way off this hell-planet was death.

It was shaping up to be another phenomenal night at the lounge. An hour into his shift and Sam had already had to pry Striddax tentacles off his wrist, watch several Knins do body shots, and had four drinks spilled on him. His head was throbbing in time with the techno grinding out of the speakers, and the bar was only going to get hotter and more packed before he could go home.

Sam hated late shifts.

He wiped several ounces of josk - more horrible alien liquor - off his hand on his apron, squeezed his eyes shut for a brief moment against the music, and picked up glasses for his next customers.

“What can I get you?” he half shouted.

“Two of those fun green things,” a guy said.

“Bucky, no,” said another.

It took Sam several moments to realize that the translator in his ear wasn’t delayed at all, which meant–

Sam looked up and met two pairs of completely, perfectly human eyes. He stared for a moment.

“Don’t be a spoilsport, Steve,” the first man - Bucky - said. He had dark hair pulled into a little bun and broad shoulders. The arm he had leaning casually on the bar was metal. He winked at Sam. “We can have some fun.”

Sam’s eyebrows went up because wow, forward, but he still smiled because humans. Humans never came into this bar. Also, they were attractive humans and Sam hadn’t been hit on by anything bipedal in a galactic age, so he really wasn’t going to complain.

The other man, Steve - tall and blonde and also very good looking - sighed, rolling his eyes.

“Excuse my partner,” he said to Sam. “He’ll make a pass at anything that walks and talks.”

“Not anything, baby,” Bucky said. “Just the good looking ones.”

Sam laughed. “Way to make a guy feel special,” he said.

“You’re a human working in this dump,” Steve said. “You must be.”

Bucky laughed, nudging Steve with an elbow. “That’s the spirit, sweetheart.” He turned back to Sam. “So, gorgeous, got a couple minutes for a drink?”

Sam was grinning, about to tell them he was up for it as long as there was no tebholhy involved, when there was a crash and a roar from not too far away.

“I’m going to wear your puny human dicks as trophies!”

Sam jerked back, staring at the Striddax that was charging through the crowd, straight at the three of them. It was the same one who’d been getting all touchy with Sam not twenty minutes ago. Awesome.

Steve turned immediately, reaching into his coat and pulling out something that looked like brass knuckles until he slipped it onto his hand and it sprouted a large, circular shield. He dove for the Striddax, catching it straight in the middle with his shield.

Bucky sighed. “Be right back,” he told Sam, and turned to the rapidly unfolding chaos as well, pulling out a gun from the back of his pants and unfolding it into an entire rifle.

Sam stared. Bar fights were normal - it was a bar in one of the biggest cities in the galaxy, after all - but they usually didn’t involve the few humans who came to Sin Sin’s, and no one was ever pulling out tech like that. Weapons weren’t even allowed in.

Everything had paused, even the music, and people were pulling away from the fight, shouting and placing bets. It looked like the Striddax, large as he was, wasn’t going to get the best of the two men, who were clearly well trained and used to working as a team. They danced around the Strid easily, ducking in and out for blows and exchanging their weapons with ease.

Sam was ready to put his money on the two of them when the Striddax managed to interrupt them in the brief hesitation that came when they switched weapons. He knocked Bucky over a table before whipping around to throw Steve into the bar.

Steve managed to partly catch himself, grunting when his torso still followed through and caught the lip of the bar. The gun he’d just gotten from Bucky whizzed past Sam and smashed several bottles of booze. Steve made eye contact with Sam for just a moment before the Striddax was on him, picking him up by the back of the shirt and throwing him into Bucky, knocking them both back over. He rushed again while they were still untangling themselves, grabbing each with two tentacles, one around their torsos, the other sliding up to encircle their skulls.

Sam didn’t really think about what he was doing. All he knew was that both humans were about to have their heads involuntarily donated to Striddax scientists, and Sam was not about to spend the night cleaning up blood and whatever else had been spilled in that particular area.

He got more josk on his hands when he scooped up the gun Steve had lost. It was weird, some kind of tech he didn’t recognize, but it had a trigger and a sight and a barrel, and it was second nature to raise it to his shoulder, aim at the Striddax’s back, and squeeze the trigger on his exhale.

The burst of green energy caught the Striddax right between the shoulders, traveled through his entire body, making him seize up for a moment before he fucking exploded, spattering everything in a thirty foot radius with gore.

The room went quiet. Sam lowered the gun. Damn it. Now he was going to have to clean up Strid blood instead. Brilliant.

Bucky and Steve were picking themselves up, heads still attached and coated in Striddax guts. Bucky wiped his eyes while reaching into his coat and pulling out another gun.

“No one steps into this area,” he said, shaking entrails violently off his hand and glaring at the quiet crowd. “Unless you want the same.”

Steve was rooting around in the gore on the ground, eventually pulling up the Strid’s biometric identifier. He tossed it to Bucky, then waved a hand at the crowd. “Carry on.”

There was another brief moment of silence, and then the music started back up, the beat drop spurring a huge cheer from the crowd. Steve and Bucky trudged over to the bar, looked at the disgusting stools, then sat down.

“Thanks,” Steve said.

Sam blinked at them. “What the fuck.”

“There’s a thirty million credit bounty on that guy’s head,” Steve said.

“Can I have my gun back?” Bucky asked.

Sam was about to hand it over, then paused. “Did you say thirty million?”

Both of them gave him wary looks, then nodded.

“Great,” Sam said. He examined the gun for a moment, then found the mechanism to fold it back into its smaller size. He held it out, just out of Bucky’s reach.

“That splits nicely three ways,” he said.

“We did all the work!” Bucky said.

“Fine.” Sam shrugged. “Call it payment for keeping you in one piece, and getting me covered in Striddax.”

Bucky opened his mouth to protest again, and Steve laid a hand on his shoulder.

“You’d have to come all the way back to Huebli with us,” Steve said mildly. “That’s at least a week long trip.”

“A trip off this planet with two attractive bounty hunters and ten million credits waiting at the end?” Sam smiled and tucked the gun into the back of his pants before yanking off his apron.

“When do we leave?”

[smartbloodsuger]

Smart Blood Sugar What is Diabetic Nephropathy?

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Diabetic nephropathy is a long-term kidney disease that can affect people with diabetes. It is also known as Diabetic Kidney Disease (DKD). It happens when a person's kidneys are damaged by elevated blood glucose levels.

Diabetic nephropathy is a leading cause of chronic kidney disease and end-stage renal disease (ESRD). The kidneys in ESRD are no longer able to satisfy the demands of everyday life. Kidney failure can occur as a result of ESRD, which can be life-threatening.

What are the risk factors for Diabetic Nephropathy?

The risk factors for diabetic nephropathy incorporate smoking, and comorbidities, and is more prevalent in people who are more than 62-65 years old. An individual with diabetic nephropathy may not experience any symptoms in the early stages. Changes in blood pressure and fluid equilibrium in the body, on the other hand, may already be present. Waste products can accumulate in the blood over time, causing symptoms.

Swollen feet and ankles, darker urine, and shortness of breath are some of the symptoms presented in the later stages. Depending on a low glomerular filtration rate, (GFR), which also represents the percentage of successful kidney function, a doctor may divide kidney disease into stages, which range from stage 1 to 5.

Certain blood tests along with urine tests are advised to attain a diagnosis for diabetic nephropathy. Urine analysis and correct recording of the history of supine or erect blood pressure must be done. Albumin is also measured as the earliest clinically detectable evidence of the said condition.

The first step in treating diabetic nephropathy is to monitor and manage diabetes, as well as high blood pressure if necessary (hypertension). Kidney disease and other complications may be avoided or delayed with proper blood sugar and hypertension treatment. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) can help to lower blood pressure, protect kidney function, and prevent further damage.

What is Diabetic Nephropathy Market Size?

The increase in market size is a direct consequence of an increase in prevalent cases of diabetes, thereby a rise in the number of cases of Diabetic Kidney Disease. In addition to this, increase in R&D activity, and awareness programs for diabetes and kidney-related issues in the 7MM.

The prevalence of diabetes worldwide has extended epidemic magnitudes and is expected to affect millions of people in the upcoming years. 34.2 million people in the United States have diabetes in 2018, accounting for 10.5% of the total population. Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in the United States and other Western societies. It is also one of the most significant long-term complications in terms of morbidity and mortality for individual patients with diabetes.

Also, Read Diabetic Nephropathy Market Report

What is Diabetic Nephropathy Treatment?

Treatment of patients with diabetic nephropathy can be divided into four major areas: cardiovascular risk reduction, glycemic control, blood pressure control, and inhibition of the renin-angiotensin system (RAS). Recommendations for therapy include targeting a hemoglobin A1c concentration < 7% and blood pressure < 140/90 mm Hg with therapy anchored around the use of a RAS-blocking agent. The single best evidence-based therapy for diabetic nephropathy is therapy with a RAS-blocking medication. The first step in treating diabetic nephropathy is to treat and control diabetes and, if needed, high blood pressure (hypertension). With good management of blood sugar and hypertension, one can prevent or delay kidney dysfunction and other complications.

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[arbs-high-quality-translations]

Aqours at AX: A really good idea gone really bad

TL;DR: AX is a really good idea for everyone involved. Except the seiyuu. It’s terrible for them.

Never thought my next long post would be about this.

Let’s get this clear first: I’m not mad about missing an event. I’m not getting FOMO. I’m looking at this from an objective standpoint and laying down the reasons why I think this is not a good move by staff. I’ve made these arguments before, but this is going to be my way of solidifying these points and expanding on them in more than just 280 characters. 

I will occasionally edit information in this post if more details about the AX live are released, but for the most part the points here will remain intact. All changes will be noted.

The Schedule in Question

Let’s take a look at what’s on Aqours’ plate for that week.

July 4: AX July 7: Fukuoka Day 1 July 8: Fukuoka Day 2

Well, you knew this part already. But those are just the performance days themselves. Let’s add in the flights if they really do a short trip in LA. 

July 3: Fly from Japan to LA July 4: AX July 5: Fly from LA to Japan July 5: Fly into Fukuoka July 7: Fukuoka Day 1 July 8: Fukuoka Day 2 Already not looking pretty. What we have to also account for, however, is timezone differences and live prep. Last year they landed a day before AX. Let’s add those in. June 18 -  July 2: Prep for two different lives along with any solo work July 3: Fly from Japan to LA July 3: Land in LA due to saving a day from timezones July 3: Standard dress rehearsal/stage test for AX July 4: AX July 5: Fly from LA to Japan July 6: Land in Japan due to losing a day from timezones July 6: Fly into Fukuoka July 6: Standard dress rehearsal/stage test for Fukuoka July 7: Fukuoka Day 1 July 8: Fukuoka Day 2 I can’t even figure out if it’s possible for them to do rehearsal for Fukuoka. That’s a big red flag. But you might think that if they compress the schedule as much as possible, they could possibly get to Fukuoka on the night of the 5th and rehearse on the 6th. Let’s take a look at that.

The Flights in Question

Given that these is a proper live, I would say it’s reasonable to assume that they don’t arrive the day of the actual event. Give them, at the bare minimum, a day before the event to settle down and get ready for a full length concert. No clue yet on what that means for AX, but 2-3 hours long doesn’t seem out of the question. Anything shorter and you’ve just scammed a few thousand livers.

If they arrive in LA on the morning of the 3rd (a day before, just like last time) they would need to fly out of Japan on the 3rd to compensate for timezones. Any earlier and they risk getting too acclimated to the timezone difference. Nonstop flights such as these:

seem like the best option. Not too early, not too late. They get the afternoon of the 3rd and the morning of the 4th to do anything they need. Then they perform.

The issue begins after that.

Let’s assume the live starts at about the same time again, around 6 or 7 in the evening. Add in the classic AX late start and a few delays here and there, a few delays for costume changes (it’s a full live after all) and your end time is now around 9 or 10. But we have VIP! Surely we’ll get some event for that. Add another hour, taking us to 10 or 11 before their performance obligations are even done.

Change and go straight to LAX. Surprise! It’s July 4th. Americans will know how awful the traffic is. The 20 minute drive from Microsoft Theater over to LAX is now possibly double that. The absolute earliest that Aqours can arrive at the airport is 11 PM.

Wait a second...

It’s impossible for them to fly out of LAX on the night of the 4th. They certainly can take that 1:20 AM flight in the early hours of the 5th, though. Assume they take that. Now we’ve arrived at Haneda airport in the early hours of the 6th, but that’s not where our event is. Take another flight to Fukuoka out of Haneda. Those are pretty easy to come by, but they could arrive in Fukuoka at mid-day at the earliest. Now we have another half-day on the 6th, and another half day on the 7th. Then two full days of lives.

I don’t care how superhuman you are. Three flights in three days, with two of them international, by itself will already fuck your body up. I’ve done it a few times going from Kuching to San Francisco with three flights, and it is absolute hell. And that was during summer break, when I was just being a fat fuck and sitting around doing nothing. The seiyuu have to perform three full concerts with this schedule. I’m just reading it on paper and I already don’t want to do it.

There is, however, one way to make it all more possible.

The Setlist in Question

There are two possibilities for the AX setlist: either perform older songs or perform 3L exclusives. Historically, we’ve trended towards the former. Don’t ask me why they do it, but they do. But now the seiyuu have to practice two completely different setlists, with potentially 30-40 different songs to practice for that week of lives. I doubt the number will get that big due to overlap, but you can see how this can go wrong very quickly.

Alternatively, they can perform a bunch of songs from the 3L setlist. Since they’ve been performed already, they’re mostly fair game for international lives. But this is unexplored territory. The only historical event we can look to HPT is at Anisama in the middle of 2L, and that’s a completely different beast from what we’re talking about here. And even with an AX setlist that borrows heavily from 3L, the travel and scheduling issues still stand.

B-b-but arb! You just showed us that it’s possible! It’s not overwork! Other idol groups do this all the time! 

Just because other groups do it doesn’t make it any better. We’ve seen the effects of overworked idols (remember Keyaki at Kouhaku?) and it’s definitely not pretty.

The Benefits in Question

Of course, there are benefits to growing a fanbase and bringing more events to international fans. I’m all for growing the community here in NA (with a few exceptions; you know who you are). More livers are always welcome. It makes everything more fun.

But for the companies, what expansion boils down to is pure revenue. In the long run, this makes money for Lantis, for Bandai, and for everyone involved. Is the revenue and growth really worth putting your cash cow franchise’s members through all of this? If the answer is yes, then I have serious questions that I want to direct at management.

There’s nothing I can do about all of this. It’s a decision completely out of my sight and out of my hands. If staff thinks this is okay, then I’ll let them be the judge. But I’m not going to be quiet.

Edit Log: Turns out Bushiroad doesn’t make money from the event. Bandai does, though.

[candyswift-ny]

IgA Nephropathy: Cause, Symptoms, Treatments, and Latest Research

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and can cause a severe decline in kidney function. The clinical presentation of IgAN varies widely, with some patients presenting with mild urinalysis abnormalities and, in severe cases, acute progressive glomerulonephritis. In addition, the clinical prognosis of IgAN varies, with very few patients in spontaneous remission, but about 40% of IgAN patients may progress to end-stage renal disease (ESRD) within 20 years of disease onset, at which point renal replacement therapy is required.

What is the cause of IgAN?

The cause of IgAN is not fully understood. IgAN is not just a kidney disease, it is a response of the immune system (the body's defense system) to external stimuli (such as viral infections). The immune response is what affects the kidneys. The immune response releases immunoglobulin A (IgA), a protein that helps the body fight infection. IgAN is developed when IgA proteins become trapped in the kidneys and create an inflammatory response.

The inflammatory response causes the kidneys to leak blood and protein (usually very quickly), and over many years, the kidneys may lose function, leading to kidney failure. In some cases, the disease appears to be concentrated in certain families or in certain areas. IgAN rarely occurs in African populations. Some researchers believe that genetic factors may play a role in the development of the disease.

What are the signs and symptoms of IgAN?

Signs and symptoms may be different for each person with IgAN. The most common signs include: (1) Hematuria: the presence of blood in the urine, which sometimes makes the urine dark brown or cola-colored. (2) Proteinuria: foam in the urine due to a large amount of protein leaking into the urine.

How to treat IgAN?

Measures to delay the progression of kidney function may include the following:

1. Glucocorticoids and immunosuppressive drugs: these are used to calm the immune system (the body's defense system) and stop it from attacking the glomeruli.

2. ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin-receptor blockers): these are blood pressure-lowering drugs that are used to reduce urinary protein loss and control blood pressure.

3. Dietary changes: some dietary changes may be required, such as reducing salt (sodium) and protein intake in food to reduce the burden on the kidneys to process metabolic waste.

4. Fish oil supplements: doctor may recommend vitamin supplements in the form of fish oil. Some studies have shown that this may help treat IgAN.

What’s new in IgAN treatment research?

In November 2019, a team of scientists led by Byung Chul Yu examined changes in urinary mtDNA in IgAN patients. The findings revealed that urinary ND1 and COX3 copy levels are highly connected, and they are greater in the IgAN group than in the HVs, indicating that mitochondrial damage is connected to IgAN.

In March 2021, another scientist team leading by Li Tan published a paper titled A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy. They proved that glomerular deposition of C1q is associated with worse clinicopathologic features and renal outcomes in IgAN patients. Mesangial C1q deposition is an independent risk factor for poor renal prognosis in IgAN.