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thatsnotcanonpodcasts · 5 years

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Nintendo America, Comic-Con 2019, Microrobots

Yes, it is that time at last; the latest episode from the Nerds is here, so everyone can relax, the wait is over. Once again, we bring you an awesome show that is jam packed full of the topics that are crossing our desks. First up we bring you news that many of us will find refreshing, Buck does. Now hold tight to your pencils as we tell you about how the all-powerful Nintendo are being sued in a class action because of faulty equipment involved in the Switch. Want to know more to see if this can help you with that dodgy gadget playing up? Well it is the first topic and there is some truly interesting developments arising from this.

Next we have a brief news update from San Diego Comic Con, with the talk from Marvel and also some from DC. No, we still aren’t getting paid by them, contrary to the way it appears. But there are some really cool things coming up to look forward to from both groups. We hear about the Marvel Phase 4 universe and the various upcoming movies. DJ is excited about these and is quite eager to see these unfold. There is the news about the various DC series with some shows seeing a possible end and others announcing the latest seasons.

Next up we need to go grab our magnifying glasses as we look at micro bots. That’s right micro bots, tiny little robots that are going to help change the world. One operates in response to specific frequencies and is called a Bristle bot, totally cool. The other is even smaller and is operated by optoelectronic tweezers (OET), which use light patterns to directly interact with the bots. That’s right – LIGHT FEAKING TWEEZERS!!! Sorry about that, but that is so cool, these bots are so small normal tweezers are too big. Would you like to know more? Well then, you are going to love this, listen to the episode and you will hear a lot more.

As normal we have the Shout outs, Remembrances, Birthdays and Special Events for the week. What do you me and a poltergeist have in common, probably more than you would realise, to find out more head over to our friends at the great new podcast from TNC by that very name (You, me and a poltergeist). Now that is a Segway, now it is time for me to go, time for this to end, but before I vanish let me just say this last little thing. Look after yourselves and take care of each other, stay hydrated and keep Nerdy. Catch you all next time.

EPISODE NOTES:

Nintendo America being Sued

-http://chimicles.com/cskd-files-class-action-lawsuit-against-nintendo-of-america-inc-relating-to-joy-con-drifting-issues/

-http://www.nintendolife.com/news/2019/07/class_action_lawsuit_officially_filed_against_nintendo_for_switch_joy-con_drifting_issues

-https://www.kotaku.com.au/2019/07/nintendo-responds-to-sufferers-of-joy-con-drift/

Comic-con Announcements - https://comicbook.com/marvel/2019/07/21/marvel-phase-4-schedule-complete-kevin-feige-comic-con/

Microrobots in cells

- https://www.scienceandtechnologyresearchnews.com/these-u-of-t-researchers-use-tiny-microrobots-to-scoop-up-transport-and-deliver-cell-material/

- https://www.scienceandtechnologyresearchnews.com/tiny-vibration-powered-robots-are-the-size-of-the-worlds-smallest-ant/

Games currently playing

Professor

– They Are Billions - https://store.steampowered.com/app/644930/They_Are_Billions/

Buck

– Company of Heroes - https://store.steampowered.com/app/228200/Company_of_Heroes/

– Dawn of War 40,000 : Dawn of War - https://store.steampowered.com/app/4570/Warhammer_40000_Dawn_of_War__Game_of_the_Year_Edition/

Other topics discussed

Graphite (a crystalline form of the element carbon)

- https://en.wikipedia.org/wiki/Graphite

Nintendo: Quality over quantity

- https://www.gamasutra.com/view/news/336293/Quality_over_quantity_is_Nintendos_firstparty_focus_as_the_Switch_nears_year_3.php

Xbox Red ring of death

- https://en.wikipedia.org/wiki/Xbox_360_technical_problems

PS4 Blue screen of death

- https://www.reddit.com/r/PS4/comments/7byh2i/blue_screen_of_death_on_ps4/

Nintendo 64 joystick injuries

- https://www.cnet.com/news/nintendo-offers-glove-to-prevent-joystick-injuries/

Nintendo 3DS problems and solutions

- https://www.digitaltrends.com/gaming/common-nintendo-3ds-problems-and-how-to-fix-them/

Simu Liu (Chinese-Canadian actor playing Shang Chi)

- https://en.wikipedia.org/wiki/Simu_Liu

Green Book (2018 film)

- https://en.wikipedia.org/wiki/Green_Book_(film)

Young Justice (DC animated TV series)

- https://en.wikipedia.org/wiki/Young_Justice_(TV_series)

DC Universe Animated Original Movies

- https://en.wikipedia.org/wiki/DC_Universe_Animated_Original_Movies

Batman: Hush (DC animated movie)

- https://en.wikipedia.org/wiki/Batman:_Hush_(film)

How to make a bristle bot

- https://www.robotgear.com.au/Share.aspx/Post/5

K’nex

- https://www.knex.com/

The optoelectronic microrobot: A versatile toolbox for micromanipulation

- https://www-pnas-org.ezp01.library.qut.edu.au/content/pnas/116/30/14823.full.pdf

Mu or µ (SI prefix for micro)

- https://en.wikipedia.org/wiki/Mu_(letter)#Measurement

Prey (2002 Michael Crichton novel)

- https://en.wikipedia.org/wiki/Prey_(novel)

Help KyoAni Heal

- GoFundMe link - https://www.gofundme.com/f/help-kyoani-heal

Kyoto Animation has opened an account to receive donations

- http://www.kyotoanimation.co.jp/information/?id=3075

Kyoto animation studio and their works

- https://en.wikipedia.org/wiki/Kyoto_Animation

Rutger Hauer (Dutch actor 1944 – 2019)

- https://en.wikipedia.org/wiki/Rutger_Hauer

"Tears in rain" is a monologue delivered by character Roy Batty (portrayed by Rutger Hauer) in the 1982 Ridley Scott film Blade Runner.

- https://en.wikipedia.org/wiki/Tears_in_rain_monologue

Shoutouts

18 Jul 2019 - Kyoto animation studio fire - https://www.hollywoodreporter.com/news/kyoto-animation-anime-studio-arson-attack-1225232

23 Jul 1967 - First successful liver transplant, on 19-month-old Julie Rodriguez by Dr Starzl at the University of Colorado - https://www.express.co.uk/news/obituaries/777849/lives-remembered-dr-thomas-starzl-liver-surgeon-pioneer

23 Jul 2015 - NASA's Kepler mission announces discovery of the most Earth-like planet yet - Kepler-452b, 1,400 light years from Earth - https://en.wikipedia.org/wiki/Kepler-452b

Remembrances

23 Jul 1916 - William Ramsay, Scottish chemist who discovered the noble gases and received the Nobel Prize in Chemistry in 1904 "in recognition of his services in the discovery of the inert gaseous elements in air" (along with his collaborator, John William Strutt, 3rd Baron Rayleigh, who received the Nobel Prize in Physics that same year for their discovery of argon). After the two men identified argon, Ramsay investigated other atmospheric gases. His work in isolating argon, helium,neon, krypton and xenon led to the development of a new section of the periodic table. He died from nasal cancer at the age of 63 in High Wycombe,Bucks. - https://en.wikipedia.org/wiki/William_Ramsay

23 Jul 1942 - Valdemar Poulsen, Danishengineer who made significant contributions to early radio technology. He developed a magnetic wire recorder called the telegraphone in 1898 and the first continuous wave radio transmitter, the Poulsen arc transmitter, in 1903, which was used in some of the first broadcasting stations until the early 1920s. He died from natural causes at the age of 72 in Gentofte. - https://en.wikipedia.org/wiki/Valdemar_Poulsen

23 Jul 2012 - Sally Ride, Americanastronaut and physicist. She joined NASA in 1978 and became the first American woman in space in 1983. Ride was the third woman in space overall, after USSR cosmonautsValentina Tereshkova and Svetlana Savitskaya. Ride remains the youngest American astronaut to have traveled to space, having done so at the age of 32. After flying twice on the Orbiter Challenger, she left NASA in 1987. She worked for two years at Stanford University's Center for International Security and Arms Control, then at the University of California, San Diego as a professor of physics, primarily researching nonlinear optics and Thomson scattering. She served on the committees that investigated the Challenger and Columbia space shuttle disasters, the only person to participate in both. She died from pancreatic cancer at the age of 61 in La Jolla, California. - https://en.wikipedia.org/wiki/Sally_Ride

Famous Birthdays

21 Jul 1951 - Robin Williams, American actor and comedian. Williams began performing stand-up comedy in San Francisco and Los Angeles during the mid-1970s, and is credited with leading San Francisco's comedy renaissance. After rising to fame playing the alien Mork in the sitcom Mork & Mindy (spun off from Happy Days), Williams established a career in both stand-up comedy and feature film acting. He was known for his improvisation skills and the wide variety of memorable character voices he created. Williams has been voted the funniest person of all time. Williams was nominated four times for the Academy Awards, winning for Best Supporting Actor for his performance as psychologist Sean Maguire in Good Will Hunting. He also received two Primetime Emmy Awards, six Golden Globe Awards, two Screen Actors Guild Awards, and four Grammy Awards. He was born in Chicago,Illinois - https://en.wikipedia.org/wiki/Robin_Williams

23 Jul 1892 - Haile Selassie, was an Ethiopian regent from 1916 to 1930 and emperor from 1930 to 1974. He is a defining figure in modern Ethiopian history. During his rule the Harari people were persecuted and many left the Harari Region. His regime was also criticized by human rights groups as autocratic and illiberal, such as Human Rights Watch. Among the Rastafari movement, whose followers are estimated to number between 700,000 and one million, Haile Selassie is revered as the returned messiah of the Bible, God incarnate. Beginning in Jamaica in the 1930s, the Rastafari movement perceives Haile Selassie as a messianic figure who will lead a future golden age of eternal peace, righteousness, and prosperity. He was born in Ejersa Goro - https://en.wikipedia.org/wiki/Haile_Selassie

23 Jul 1967 - Philip Seymour Hoffman, American actor, director, and producer. Best known for his distinctive supporting and character roles – typically lowlifes, eccentrics, bullies, and misfits – Hoffman acted in many films from the early 1990s until his death in 2014. He began his screen career in a 1991 episode of Law & Order and started to appear in films in 1992. He gained recognition for his supporting work, notably in Scent of a Woman, Boogie Nights,Happiness, Patch Adams, The Talented Mr. Ripley among other movies. He began to occasionally play leading roles, and for his portrayal of the author Truman Capote in Capote, won multiple accolades, including the Academy Award for Best Actor. Hoffman's profile continued to grow and he received three more Oscar nominations for his supporting work in Charlie Wilson's War, Doubt & The Master. Remembered for his fearlessness in playing reprehensible characters, and for bringing depth and humanity to such roles, Hoffman was described in his New York Times obituary as "perhaps the most ambitious and widely admired American actor of his generation". He was born in Fairport, New York - https://en.wikipedia.org/wiki/Philip_Seymour_Hoffman

23 Jul 1989 - Daniel Radcliffe, English actor and producer. He is known for playing the titular protagonist in the Harry Potter film series, based on the novels by J. K. Rowling. Radcliffe made his acting debut at 10 years of age in BBC One's 1999 television film David Copperfield, followed by his cinematic debut in 2001's The Tailor of Panama. At age 11, he was cast as Potter in the series' first film Harry Potter and the Philosopher's Stone, and starred in the series for 10 years, starring in the lead role in all eight films culminating with the final film in the series, Harry Potter and the Deathly Hallows – Part 2, released in 2011. Radcliffe became one of the highest paid actors in the world during the filming of the Potter films, earned worldwide fame, popularity, and critical acclaim for his role, and received many accolades for his performance in the series. Following the success of Harry Potter, he acted in other movies such as the Edwardian horror filmThe Woman in Black, Kill Your Darlings, Victor Frankenstein, Swiss Army Man among others. Radcliffe began to branch out to stage acting in 2007, starring in the London and New York productions of Equus for which he received immense praise from critics and audiences alike, and in the 2011 Broadway revival of the musical How to Succeed in Business Without Really Trying. He was born in London - https://en.wikipedia.org/wiki/Daniel_Radcliffe

Events of Interest

23 Jul 1983 – Gimli Glider:Air Canada Flight 143 runs out of fuel and makes a deadstick landing at Gimli, Manitoba. The subsequent investigation revealed that a combination of company failures, human errors and confusion over unit measures had led to the aircraft being refuelled with insufficient fuel for the planned flight. - https://en.wikipedia.org/wiki/Gimli_Glider

23 Jul 1995 – Alan Hale and Thomas Bopp discovered Comet Hale-Bopp separately before it became visible to the naked eye. It is difficult to predict the maximum brightness of new comets with any degree of certainty, but Hale–Bopp met or exceeded most predictions when it passed perihelion on April 1, 1997. It was visible to the naked eye for a record 18 months, twice as long as the Great Comet of 1811, the previous record holder. Accordingly, Hale–Bopp was dubbed the Great Comet of 1997. - https://en.wikipedia.org/wiki/Comet_Hale%E2%80%93Bopp

23 Jul 1999 – Space Shuttle Columbia launches on STS-93, with Eileen Collins becoming the first female space shuttle commander. The shuttle also carried and deployed the Chandra X-ray Observatory.

- https://en.wikipedia.org/wiki/STS-93

- https://www.nasaspaceflight.com/2019/07/sts-93-at-twenty-years-planning-to-launch-chandra/

Intro

Artist – Goblins from Mars

Song Title – Super Mario - Overworld Theme (GFM Trap Remix)

Song Link - https://www.youtube.com/watch?v=-GNMe6kF0j0&index=4&list=PLHmTsVREU3Ar1AJWkimkl6Pux3R5PB-QJ

Email - [email protected]

Twitter - https://twitter.com/NAmalgamated

Spotify - https://open.spotify.com/show/6Nux69rftdBeeEXwD8GXrS

iTunes - https://itunes.apple.com/au/podcast/top-shelf-nerds/id1347661094

RSS - http://www.thatsnotcanonproductions.com/topshelfnerdspodcast?format=rss

#gaming #science #console gaming #nintendo #xbox #marvel #pop culture #scifi #thor #science fiction #lawsuit #biology batman #science news #comic new #nonotechnology #simu liu #kyoani #kyoto animation

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ionecoffman · 5 years

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The CRISPR Baby Scandal Gets Worse by the Day

Before last week, few people had heard the name He Jiankui. But on November 25, the young Chinese researcher became the center of a global firestorm, when it emerged that he had allegedly made the first CRISPR-edited babies, twin girls named Lulu and Nana. Antonio Regalado broke the story for MIT Technology Review, and He himself described the experiment at an international gene-editing summit in Hong Kong. After his talk, He revealed that a another early pregnancy is underway.

It is still unclear if He did what he claims to have done. Nonetheless, the reaction was swift and negative. The CRISPR pioneer Jennifer Doudna says she was “horrified”, NIH Director Francis Collins said the experiment was “profoundly disturbing,” and even Julian Savulescu, an ethicist who has described gene-editing research as “a moral necessity” described He’s work as “monstrous.”

Such a strong reaction is understandable, given the many puzzling and worrying details about the experiment. Even without any speculation about designer babies and “Gattaca”-like futures that may or may not come to pass, the details about what has already transpired are galling enough. If you wanted to create the worst possible scenario for introducing the first gene-edited babies into the world, it is difficult to imagine how you could improve on this 15-part farce.

1. He didn’t address an unmet medical need.

He focused on a gene called CCR5, which the HIV virus uses as a doorway for infiltrating human cells. To lock the virus out, several scientists have tried extracting the immune cells of HIV patients and deactivating CCR5 using gene-editing techniques before injecting the cells back into the body. Although Nana and Lulu’s father is HIV-positive, neither of the infants actually had HIV. As I’ve written before, He’s team deactivated a perfectly normal gene in an attempt to reduce the risk of a disease that neither child had—and one that can be controlled through safe-sex education, or antiviral drugs. Even if you wanted to block CCR5 specifically, there are drugs out there that could do the job, many of which have been repeatedly tested in clinical trials. The rationale for using a method as extreme and untested as gene editing doesn’t hold up.

[Read: A reckless and needless use of gene editing on human embryos]

Deactivating CCR5 doesn’t confer complete immunity to HIV either, since some strains of the virus can enter cells via a different protein. And although people with natural deficiencies in the gene appear healthy, they might be more susceptible to West Nile virus, and be more likely to die when they catch influenza. Essentially, He gave Nana and Lulu resistance to a virus that they could avoided in myriad other ways, and may have opened them up to other dangers.

2. The actual editing wasn’t executed well.

He’s data haven’t been published or peer-reviewed, so many of the details of his experiment are unclear. But based on the slides that he presented at the Hong Kong summit, other scientists have denounced the work for being amateurish.

For example, it appears that He only managed to edit half of Lulu’s CCR5 genes; the rest are normal. That could either be because every cell in her body has one normal copy of CCR5 and one edited one (she’s heterozygous) or that half of her cells carry two edited genes and half carry two normal ones (she’s mosaic). If the former, she would not be resistant to HIV. If the latter, it depends on whether her immune cells specifically carry the edits. The same might apply to Nana, who, based on the slides, seems to also have normal copies of CCR5 somewhere.

What’s more, the edited cells don’t seem to have been edited in the right way. He planned to delete a small section of the CCR5 gene, mimicking a naturally occurring mutation called delta 32 that’s found in around 10 percent of Europeans. But according to Sean Ryder, a biochemist from the University of Massachusetts Medical School, He’s slides show no sign of delta 32 in either girl. Instead, Lulu has an entirely different CCR5 mutation, and Nana has two. These are in roughly the same part of the gene, but “it’s a fairly outrageous assumption that any change to this region would lead to some benefit,” Ryder says. “He made new mutations, and there’s no reason to think that they’d be protective—or even that they’d be safe.”

3. It’s not clear what those new mutations will do.

At least two of the three mutations that He introduced into Nana and Lulu’s genomes are substantial changes that could alter how CCR5 works. Typically, scientists would introduce the same mutations into mice or other lab animals to see what would happen. If they felt reassured enough to move into human patients, they could recruit patients with HIV, take out some immune cells, introduce the new CCR5 mutations, transplant the cells back, and monitor the volunteers to see if they’re healthy. “That could take months or years but to do anything less would be cutting corners,” Ryder says.

But He appears to have leapfrogged over all of those basic checks, and implanted the edited embryos into a woman. “The children are test subjects for variants that haven't been vetted in animals,” Ryder says. What’s shocking about this “is the blatant disregard of all the rules and conventions we have in place for how one should approach any proposed intervention,” said Leonid Kruglyak, a geneticist at the University of California at Los Angeles, on Twitter.

4. There were problems with informed consent.

It’s not clear if the participants in He’s trial were actually aware of what they were signing up for. He relied on an AIDS association to reach out to the patients, and falsely described his work as an “AIDS vaccine development project.” He told delegates at the Hong Kong summit that he personally took the volunteers through the informed consent process, along with another professor. But taking consent is a specific skill that requires training; He had none.

The consent document that he used describes CRISPR and gene editing, but does so in heavily technical language. He has said his patients were “very well educated” and already knowledgeable about gene-editing technology. But according to a news report from the Chinese magazine Sanlian Life Week (which has since been removed, but not before a digital copy was saved and translated), one of the people who dropped out of the experiment had only a high-school understanding of biology, and only heard the term “gene editing” when news stories about He’s experiment broke. The man claimed that he was not informed about the risks of off-target effects, or that gene editing was a prohibited and ethically controversial technology.

Also, the consent form “is not a consent form,” says Kelly Hills, a bioethicist at Rogue Bioethics. “It’s a business form, of the kind that a company might use when subcontracting.” For example, the section about possible risks says nothing about any negative consequences of deactivating CCR5, and is instead more focus on absolving He’s team of legal responsibility for problems arising from the procedure. The form also gives He’s team rights to use photos of the babies in magazines, calendars, billboards, propaganda, product packaging, and posters in cars and elevators.

5. He operated under a cloak of secrecy …

By his own admission, He didn’t tell his institution, the Southern University of Science and Technology, about the experiment, and took a stint of unpaid leave in February to begin work in secret. The university plans to launch an investigation into the project, which it called a “serious violation of academic ethics and standards” in a statement.

He also claims that he received ethical approval from Shenzhen Harmonicare Hospital. But in a statement, the hospital says that the Medical Ethics Committee never met to discuss such a project, and that the signatures on He’s approval “are suspected to have been forged.” Meanwhile, He’s laboratory webpage has disappeared, as have statements praising his other work on government sites.

6. … but organized a slick PR campaign

Given how many people He kept in the dark, it is all the more striking that he was simultaneously organizing a public-relations effort. He contacted the Associated Press months ago to prep a story that would launch when he unveiled his work at the Hong Kong summit. He engaged the services of an American PR consultant, Ryan Ferrell. He created a set of five YouTube videos describing his actions and the rationale behind them. And all this while the actual technical details of his work have yet to be released in any official publication.

7. A few people knew about He’s intentions but failed to stop him.

Even though He spoke at scientific conferences about his gene-editing research in other animals, he only discussed his ambitions to edit human embryos with a select few. Those included his former advisor Michael Deem of Rice University, who played an active role in the project and was reportedly present in China when several patients were consented. (Deem holds a small stake in He’s two companies, and is under investigation for his involvement in the matter.)

Other scientists were not supportive. As reported in STAT, He also consulted Mark DeWitt of the UC Berkeley, who told him not to go ahead with the project. The AP also reported that He expressed an interest in editing human embryos to his former advisor, Stephen Quake from Stanford University, who cautioned him in broad terms to seek ethical advice. This February, He also told Stanford’s Matthew Porteus that he had hospital approval to proceed with his experiment. Porteus told the AP that he was angry at He’s naïvete and recklessness, but after chiding him, assumed that he would not go ahead.

The chair of the Hong Kong summit, David Baltimore, called the episode “a failure of self-regulation by the scientific community.” Baltimore urged other scientists in the field who learn about experiments like He’s to alert the authorities. But this “see something, say something” approach won’t work, says Kelly Hills, the bioethicist. “Would scientists actually recognize a bad actor if one was working with them?” she says. “The answer is no. We simply assume that if someone is a colleague, they have shared values.”

“And who do you say something to?” she adds. “We don’t have an international group that oversees gene editing.” China is unusual in that it actually does have a medical-ethics agency that oversees all medical research in the country, and that Porteus or others could have contacted. The U.S. does not, and the work that He did would only have been illegal if it had been federally funded. “Literally every single thing He did could have happened in America,” Hills says.

8. He acted in contravention of global consensus.

To the extent that there was any global consensus about using gene-editing technologies on human embryos, it was: Don’t rush into it. That was the feeling in 2015 when the U.S. National Academies of Science, Engineering, and Medicine convened an international summit of scientists, ethicists, and others to discuss the topic. And it was the view of a landmark report that the same group published in 2017.

The report did not call for an outright ban on germline gene editing—that is, altering the DNA of sperm, eggs, or embryos in ways that could cascade through generations—but said that “there is a need for caution.” It only be done in clinical trials with “rigorous oversight,” “maximum transparency,” and an “absence of reasonable alternatives,” and only after “much more research to meet appropriate risk/benefit standards” and “broad participation and input by the public.”

He’s work, which was both rushed and cloaked in secrecy, clearly did not fit these criteria. And as reported by Antonio Regalado at MIT Technology Review, He wrote in the ethics proposal that accompanied his experiment that the National Academies in their 2017 report had “for the first time” approved germline gene editing in human embryos to treat or prevent serious disease. It’s as if he took the absence of a red light as a green one.

9. He acted in contravention of his own stated ethical views.

Last July, He spoke at a conference at Cold Spring Harbor Laboratory. He didn’t mention his plans to edit human embryos, but he brought up the case of Jesse Gelsinger, an American teen who died in a botched gene-therapy trial in 1999. To avoid such deaths, and the chilling effect that they can have on research, He urged scientists to move cautiously before editing the genome of embryos.

He also published a paper in The CRISPR Journal that lays out ethical principles, such as transparency, that he himself violated. The paper was in the works well before the news of the babies broke, and was published two days afterward. Ryan Ferrell, He’s PR consultant, is one of the co-authors.

10. He sought ethical advice and ignored it

Sharon Begley at STAT reports that He spoke at length with two bioethicists, William Hurlbut at Stanford University and his son Benjamin Hurlbut at Arizona State University. Neither one was aware of He’s plans, but spent time telling him about their conservative Catholic stance on ethics, in which human life begins at conception. “It seems like He came to the conclusion that ethics was synonymous with Christianity,” Hills says. That allowed him to politely disregard the Hurlbuts’ opinions and “develop his own personal code that reads like what you would expect from a freshman in the first weeks of Bioethics 101.”

11. There is no way to tell if He’s work did any good.

Both Nana and Lulu will be monitored at least until they turn 18. But “the children were already at virtually no risk of contracting HIV,” said Alta Charo, a bioethicist from the University of Wisconsin at Madison, in a statement. This means that “there is no way to evaluate if this indeed conferred any benefit. If they remain HIV-negative, there is no way to show it has anything to do with the editing.”

At the Hong Kong summit, He was asked if the two children would be treated differently by their parents, who will know that they have been edited. “I don’t know how to answer this question,” He said.

12. He has doubled down.

If He shows any contrition about how these events have unfolded, it has not been obvious. Speaking at the Hong Kong summit, he apologized, but only because news about his work “leaked unexpectedly” before he could present it in a scientific venue. That, He said, took away from the community. Regarding the experiment itself, he said: “I feel proud.”

13. Scientific academies have prevaricated.

In the wake of He’s bombshell, several scientists, including the CRISPR pioneer Feng Zhang and the stem-cell biologist Paul Knoepfler, have called for a temporary moratorium on similar experiments. The organizers of the recent Hong Kong summit have not. After the news first broke, the organizing committee of the Hong Kong summit, which includes representatives from scientific academies in Hong Kong, the U.K., and the U.S., released a bland statement in which they simply restated the conclusions from their earlier report. A second statement, released after the summit, was stronger, calling He’s claims “deeply disturbing” and his work “irresponsible.”

But the second statement still discusses the creation of more gene-edited babies as a goal that should be worked toward. The risks are “too great to permit clinical trials of germline editing at this time,” it says, but “it is time to define a rigorous, responsible translational pathway toward such trials.” George Daley from Harvard Medical School, one of the meeting’s co-organizers, made similar points during the event itself. Given that the world is still grappling with the implications of what has happened, “no, it’s not time yet and it’s tone-deaf to say so,” says Hank Greely, an ethicist at Stanford.

“Although the chair opened the summit by invoking Huxley’s Brave New World, few of the discussions at the meeting, and nothing in the concluding statement, suggest a meaningful engagement with social consequences,” says the Center for Genetics in Society, a watchdog group.

14. A leading geneticist came to He’s defense.

In an interview with Science, George Church, a respected figure from Harvard and a CRISPR pioneer, said that he felt “an obligation to be balanced about” the He affair. Church suggested that the man was being bullied and that the “most serious thing” about his experiment was “that he didn’t do the paperwork right.” “[Church’s] comments are incredibly irresponsible,” says Alexis Carere, who is president-elect of the Canadian Association of Genetic Counselors. “If someone contravenes the rules that we have laid down, we are very justified in speaking out about it. The unfortunate effect of this is that it makes it seem like there is some kind of balance, and George is just in the middle. There is not.”

Carere was also dismayed at the rest of the interview, where “every sentence was a new ethical maxim that I had never heard of,” she says. For example, Church noted that “as long as these are normal, healthy kids it’s going to be fine for the field and the family.” But unethical actions are still unethical, even if nothing goes wrong. Arguing otherwise gives a pass to scientists who blow past ethical norms, provided they find something interesting. “It’s bizarro-land consequentialist ethics,” Carere says.

15. This could easily happen again.

Last year, the world learned that a group of scientists had resurrected a virus called horsepox. Several researchers and ethicists criticized that work, arguing that it would make it easier for others to recreate the related (and far more dangerous) smallpox virus. As I wrote in October, regardless of the risks or merits of the experiment, it reveals a vulnerability at the heart of modern science. That is: Small groups of researchers can make virtually unilateral decisions about experiments that have potentially global consequences, and that everyone else only learns about after the fact.

He Jiankui’s experiment reveals that vulnerability in the starkest possible light.

Article source here:The Atlantic

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amtushinfosolutionspage · 6 years

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DGB Grab Bag: Ovi Face, June Hockey History, and Stop Lying about Start Times

Three Stars of Comedy

The third star: Connor McDavid makes his Cup final pick – Wait, is this an option? I really should have been doing this all year long.

The second star: Matt Niskanen’s big night – You know what, I believe him. There isn’t much else to do in Las Vegas.

The first star: Alexander Ovechkin’s face – I enjoy watching Ovechkin watch playoff games.

And that was just one of several reaction shots from this week. In fact, the only thing he apparently doesn’t react to is getting hit directly in the face with a puck:

Be It Resolved

The Golden Knights hosted the first two games of the Stanley Cup Final this week, and as you’d expect, they went all-out on the spectacle. Wednesday’s second game featured an opening ceremony that including a knight, some archers, laser drummers, and a concert by Imagine Dragons, and if you’re disappointed that you missed it then you’re in luck because I’m pretty sure it’s still going on.

We’ve covered the question of the Knights’ pregame festivities before, but let me reiterate my stance here: I’m fully on board. I’m all in. Let Montreal and Detroit and whoever else deliver solemn ceremonies that honor the game’s sacred traditions. We put a hockey team in freaking Las Vegas. Let them get weird.

But maybe, just maybe, they could remember to work in the actual game too.

This is a recurring issue with NHL games, where the start times have drifted off over the years to the point where you just expect everything to be 20 minutes late. It’s not a Vegas problem; they’re just making it worse. Or maybe better, since if you have to wait around you may as well be entertained. I’d rather watch a knight fight an airplane than listen to the broadcast team go over line matchups for the third time, and I’m betting you would too.

But I’d also rather watch some hockey, at least eventually. If that makes me the fun police, then OK. That’s kind of a weird stance for a hockey fan—”Oh, this guy actually wants to watch an NHL game, he must hate fun”—but fill your boots. I don’t doubt that this is all great if you’re one of the thousands of people in the building. But there are also millions of us at home who are patiently waiting for puck drop while this rock band works through their fourth iteration of Generic Arena Sports Anthem, so maybe get to it already.

To be clear, I’m not saying the Knights should rein in their pregame fun when the series returns to town next week. Hell, I want them to take it even further. It’s the Stanley Cup Final, so go all out. Have Wayne Newton do a set. Have David Copperfield fly around the arena. Have one of those weird puppet guys that nobody has ever heard of but have like nine giant billboards all along the strip do whatever it is they do. Find that 50-foot tall Michael Jackson robot that was supposed to be wandering the desert and let it loose. Send out Mantecore to eat Tom Wilson. You’re Vegas. There are no limits.

Just, you know, maybe figure out a reasonable start time for the game and then work backwards. Start the ceremony right now if you need to. This may end up being a once-in-a-lifetime experience, so enjoy all of it. Just don’t forget the hockey part.

Obscure Former Player of the Week

There’s a chance that this will be the last Grab Bag of the playoffs, and that by next Friday the Final will be over and we’ll have crowned a champion. If so, somebody will have scored the Stanley Cup-winning goal, joining a list of players that includes Gordie Howe, Rocket Richard, Bobby Orr and Mike Bossy (twice each), and Wayne Gretzky.

That list also includes a handful of obscure players, including this week’s pick: Wayne Merrick.

Merrick was a big center who tore up the OHL for the Ottawa 67s in the early 70s. That led to the Blues making him the ninth overall pick in the 1972 draft, which was kind of terrible apart from Bill Barber and Steve Shutt. Merrick wasn’t quite as good as those two guys, but at least he made the NHL, which is more than we can say about that year’s tenth overall pick, Al Blanchard.

Merrick debuted with the Blues that season, scored ten goals, and became a regular contributor until he was traded to the Golden Seals early in the 1975-76 season. He finished that season with a career-best 32 goals, although his numbers fell off after the Seals moved to Cleveland. So did pretty much everyone else’s, come to think of it.

Merrick lucked out in 1978 when he was traded to the Islanders in a deal for J.P. Parise (Zach’s father). That Islanders team was about to become a dynasty, winning four straight Cups from 1980 through 1983, and while Merrick was hardly a star, he played a key role while centering the “Banana Line” with Bob Nystrom and John Tonelli. He’d end up playing 95 playoff games with the team, scoring 18 goals. One of those was the Cup winner in 1981, as Merrick’s goal held up in a 5-1 win over the North Stars in the Game 5 clincher.

Merrick played for the Islanders until 1984, then retired. He finished his career with 191 goals in 774 games to go along with those four Cup rings.

Debating the Issues

This week’s debate: The NHL is 101 years old. But is it fun to learn about the league’s history?

In favor: Oh for sure. Over the course of its history, the NHL has provided us with all sorts of fascinating twists and turns, both on and off the ice. I can’t think of anything more interesting than learning all about the key moments that shaped the league we have today.

Opposed: All of that is undoubtedly true, my friend. But history can be so dull and boring. Nobody wants to comb through some dry textbook just to learn about something they enjoy.

In favor: Ah, but history doesn’t have to be dry. What if you could retrace a century of key events, but in a light-hearted and easy-to-enjoy format that placed the focus on the fun and the funny?

Opposed: That sounds great! But does such a thing exist?

In favor: Wouldn’t it be great if it did?

Opposed: Hey wait, is this feeling kind of … off? This isn’t the usual tone for this section. The whole thing seems kind of forced.

In favor: Imagine sitting down with a history of the NHL that was written for the average fan, one who wants to read all about the great moments and the bizarre ones, and everything in between.

Opposed: Like, nobody talks this way. We sound ridiculous right now.

In favor: I know I’d pay top dollar for just such a book!

Opposed: Wait, is this all just some stupid plug?

In favor: But who? Who could write such a book?

Opposed: This is pathetic.

In favor: Well, there’s good news!

Opposed: Let me guess…

In favor: The Down Goes Brown History of the NHL was announced this week, and is available now for pre-order in both Canada and the USA. Hockey fans will delight in this whimsical retelling of the league’s history, with an emphasis on the weird and wonderful. From The Rocket to Mr. Rogers, The Down Goes Brown History of the NHL tells the full story of the world’s most beautiful sport, as presented by the world’s most ridiculous league.

Opposed: Did you honestly just say “whimsical”? Literally no real person has ever used that word.

In favor: In this fun, irreverent, and fact-filled history, Sean McIndoe relates the flip side to the National Hockey League’s storied past.

Opposed: You literally just cut-and-pasted that off the book cover.

In favor: Look man, I spent a year writing this thing. I barely saw my family, I almost went blind squinting at old newspaper clippings, and they’ve sent me “one last round of edits” like six times in the last month. And after all of that, the whole thing still isn’t completely finished because the stupid Golden Knights came along and wrecked one of the last chapters. So help me out here.

Opposed: Sigh. Fine. You do what you have to do.

In favor: Thanks.

Opposed: But can we go back to complaining about instant replay review soon?

In favor: Next week after the Cup-winning goal gets waved off, I promise.

The final verdict: Well gosh, looks like we’ll all be getting our Christmas shopping done early this year!

Classic YouTube Clip Breakdown

Today is the first day of June, and there was a time when that meant that the hockey season would have been long over with. Not any more, of course—the playoffs have stretched into June for years now. So today, let’s welcome the new month by going back to the first NHL game ever played in June.

It’s June 1, 1992 and we’re in Chicago for Game 4 of the Stanley Cup Final. The Penguins are up 3-0 in the series and looking for the sweep and for their second straight Cup win. As a side note, they’re also looking for the 11th straight win in a single postseason, which would tie the record previously held by [checks notes] the 1992 Blackhawks. Huh. Maybe 1992 wasn’t the best year for parity. I’m sure nobody enjoyed it.

Our clip begins with a vaguely weird aside about how the legendary Chicago Stadium will soon be torn down and replaced with a modern arena. The Stadium really was an amazing place to watch hockey, but the weird part is that it wasn’t actually replaced for two more years, so the somber tone here feels a little premature.

Speaking of the end of the Chicago Stadium, it was the Maple Leafs who shut it down, and they did it with a 1-0 win. Eat that, Hawks fans. I’m sure nothing has happened in the ensuring quarter-century that you can throw back in my face.

The scoring starts less than two minutes in when Jaromir Jagr rips a shot that makes Eddie Belfour do an adorable pirouette. Wow, one goal, I wonder if Mike Keenan will pull him, we all joke to ourselves. Yeah, hold that thought.

The Blackhawks tie it up a few minutes later, as Dirk Graham cuts across the zone and beats Tom Barrasso. I know that whenever we do these old 80s or early 90s games, we always beat the whole “goaltending was terrible back then” observation into the ground, but go back and rewatch this goal. Graham basically moves from the inside edge of one faceoff circle to the other—like maybe ten feet total—and Barrasso is reduced to having to do a sideways bunny hop to stay with him, then falls down as soon as he makes the first save. And remember, Barrasso was a borderline Hall-of-Famer. This is just how goalies moved back then. In hindsight, it’s amazing every game didn’t end up being 13-12.

On a related note, the previous game of this final was a 1-0 Penguins win. I’m not sure anything about early 90s hockey made any sense other than Mario Lemieux was good and if you fought Wendel Clark your face would explode. Other than that, you were on your own.

The Penguins come right back a few seconds later with a Kevin Stevens goal. “Ah, look out Loretta.” Did I mention that our play-by-play guy here is Mike Lange? You probably figured that part out on your own.

The Stevens goal spells the end for Belfour, which gives us the opportunity to remember that their backup was goofy European weirdo Dominik Hasek, who at this point is 28 and not very good. Two years later he’ll win the first of six Vezinas. Seriously, my “early 90s hockey made no sense” theory might be on to something.

Lange is telling us a story about Hasek being drafted in 1983 “when it wasn’t real fashionable to draft people,” at which point the Blackhawks score to make it 2-2. I know the goal interrupts Lange just as he was going to make a point about drafting Europeans, but I prefer to imagine he had completed his thought and that it was just unfashionable to draft anyone at all in 1983. (For one team, that was actually true.)

The Penguins regain the lead as Lemieux and Hasek perform a short play entitled “What the Nagano shootout should have looked like.” But Graham comes right back with his hat trick goal, and we’re tied again. At this point we have one of those fun old-hockey-highlights moments where you realize it’s still the first period and remember how much fun this sport is when everyone’s defensive strategy was “Screw defense, I’d rather score.”

Rick Tocchet somehow overcomes the ferocious backchecking of a young Jeremy Roenick to make it 4-3 early in the second. But Roenick makes amends with a fluky goal late in the period, and we head to the third tied again.

It’s always fun during a high-scoring highlights package when the guy putting the clips together is like “Oh yeah, I should probably work in one save.” In this case it’s Lemieux getting a breakaway, only to be robbed by a sprawling Hasek. Maybe scratch that thought about if Mario had been in Nagano. Not because of this save, just because I realized Marc Crawford probably would have had Eric Desjardins shoot instead.

Larry Murphy gives the Pens their fifth lead of the game, and this time they manage to pad it when Ron Francis “beats goaltender Hasek like a rented mule.” The good: Mike Lange. The bad: Every play-by-play guy from the next 25 years who convinced himself his catchphrases were as funny as Mike Lange’s.

Roenick makes it 6-5 off a feed from Stu Grimson with nine minutes left. Why yes, The Grim Reaper was still getting a regular shift with nine minutes left and his team trailing in a Cup Final elimination game. And it paid off. The early 90s. Sense made? None.

But that’s all the Hawks would get, as we cut ahead to the dying seconds. Lange does that wonderful play-by-play thing where he starts in with his “we win” call but then realizes he’s a few second early and has to backtrack. But he makes up for it with his all-time classic “Lord Stanley, Lord Stanley, bring me the brandy” call.

Wait, is it me or did he actually say “get me the brandy”? I’m pretty sure he did. This is like finding out that Sherlock Holmes never said “Elementary, my dear Watson” in any of the books. I swear, if it turns out Lange never asked us to sneak up and mutilate him with a hacksaw I’m going to question everything from my childhood.

And that’s it for our clip. The Penguins win the Cup, and the season ends just hours into June. And in case you were wondering why the season stretched on so long in 1992, it’s because there was a ten-day player strike just before the playoffs. A work stoppage, hockey being played in June, and a Blackhawks/Penguins matchup? Man, no wonder Gary Bettman couldn’t wait to get on board a few months later.

Have a question, suggestion, old YouTube clip, or anything else you’d like to see included in this column? Email Sean at [email protected].

DGB Grab Bag: Ovi Face, June Hockey History, and Stop Lying about Start Times syndicated from https://australiahoverboards.wordpress.com

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flauntpage · 6 years

Text

DGB Grab Bag: Ovi Face, June Hockey History, and Stop Lying about Start Times

Three Stars of Comedy

The third star: Connor McDavid makes his Cup final pick – Wait, is this an option? I really should have been doing this all year long.

The second star: Matt Niskanen's big night – You know what, I believe him. There isn't much else to do in Las Vegas.

The first star: Alexander Ovechkin's face – I enjoy watching Ovechkin watch playoff games.

And that was just one of several reaction shots from this week. In fact, the only thing he apparently doesn't react to is getting hit directly in the face with a puck:

Be It Resolved

The Golden Knights hosted the first two games of the Stanley Cup Final this week, and as you'd expect, they went all-out on the spectacle. Wednesday's second game featured an opening ceremony that including a knight, some archers, laser drummers, and a concert by Imagine Dragons, and if you're disappointed that you missed it then you're in luck because I'm pretty sure it's still going on.

We've covered the question of the Knights' pregame festivities before, but let me reiterate my stance here: I'm fully on board. I'm all in. Let Montreal and Detroit and whoever else deliver solemn ceremonies that honor the game's sacred traditions. We put a hockey team in freaking Las Vegas. Let them get weird.

But maybe, just maybe, they could remember to work in the actual game too.

This is a recurring issue with NHL games, where the start times have drifted off over the years to the point where you just expect everything to be 20 minutes late. It's not a Vegas problem; they're just making it worse. Or maybe better, since if you have to wait around you may as well be entertained. I'd rather watch a knight fight an airplane than listen to the broadcast team go over line matchups for the third time, and I'm betting you would too.

But I'd also rather watch some hockey, at least eventually. If that makes me the fun police, then OK. That's kind of a weird stance for a hockey fan—"Oh, this guy actually wants to watch an NHL game, he must hate fun"—but fill your boots. I don't doubt that this is all great if you're one of the thousands of people in the building. But there are also millions of us at home who are patiently waiting for puck drop while this rock band works through their fourth iteration of Generic Arena Sports Anthem, so maybe get to it already.

To be clear, I'm not saying the Knights should rein in their pregame fun when the series returns to town next week. Hell, I want them to take it even further. It's the Stanley Cup Final, so go all out. Have Wayne Newton do a set. Have David Copperfield fly around the arena. Have one of those weird puppet guys that nobody has ever heard of but have like nine giant billboards all along the strip do whatever it is they do. Find that 50-foot tall Michael Jackson robot that was supposed to be wandering the desert and let it loose. Send out Mantecore to eat Tom Wilson. You're Vegas. There are no limits.

Obscure Former Player of the Week

There's a chance that this will be the last Grab Bag of the playoffs, and that by next Friday the Final will be over and we'll have crowned a champion. If so, somebody will have scored the Stanley Cup-winning goal, joining a list of players that includes Gordie Howe, Rocket Richard, Bobby Orr and Mike Bossy (twice each), and Wayne Gretzky.

That list also includes a handful of obscure players, including this week's pick: Wayne Merrick.

Merrick was a big center who tore up the OHL for the Ottawa 67s in the early 70s. That led to the Blues making him the ninth overall pick in the 1972 draft, which was kind of terrible apart from Bill Barber and Steve Shutt. Merrick wasn't quite as good as those two guys, but at least he made the NHL, which is more than we can say about that year's tenth overall pick, Al Blanchard.

Merrick lucked out in 1978 when he was traded to the Islanders in a deal for J.P. Parise (Zach's father). That Islanders team was about to become a dynasty, winning four straight Cups from 1980 through 1983, and while Merrick was hardly a star, he played a key role while centering the "Banana Line" with Bob Nystrom and John Tonelli. He'd end up playing 95 playoff games with the team, scoring 18 goals. One of those was the Cup winner in 1981, as Merrick's goal held up in a 5-1 win over the North Stars in the Game 5 clincher.

Merrick played for the Islanders until 1984, then retired. He finished his career with 191 goals in 774 games to go along with those four Cup rings.

Debating the Issues

This week’s debate: The NHL is 101 years old. But is it fun to learn about the league's history?

In favor: Oh for sure. Over the course of its history, the NHL has provided us with all sorts of fascinating twists and turns, both on and off the ice. I can't think of anything more interesting than learning all about the key moments that shaped the league we have today.

Opposed: All of that is undoubtedly true, my friend. But history can be so dull and boring. Nobody wants to comb through some dry textbook just to learn about something they enjoy.

In favor: Ah, but history doesn't have to be dry. What if you could retrace a century of key events, but in a light-hearted and easy-to-enjoy format that placed the focus on the fun and the funny?

Opposed: That sounds great! But does such a thing exist?

In favor: Wouldn't it be great if it did?

Opposed: Hey wait, is this feeling kind of … off? This isn't the usual tone for this section. The whole thing seems kind of forced.

In favor: Imagine sitting down with a history of the NHL that was written for the average fan, one who wants to read all about the great moments and the bizarre ones, and everything in between.

Opposed: Like, nobody talks this way. We sound ridiculous right now.

In favor: I know I'd pay top dollar for just such a book!

Opposed: Wait, is this all just some stupid plug?

In favor: But who? Who could write such a book?

Opposed: This is pathetic.

In favor: Well, there's good news!

Opposed: Let me guess…

In favor: The Down Goes Brown History of the NHL was announced this week, and is available now for pre-order in both Canada and the USA. Hockey fans will delight in this whimsical retelling of the league's history, with an emphasis on the weird and wonderful. From The Rocket to Mr. Rogers, The Down Goes Brown History of the NHL tells the full story of the world's most beautiful sport, as presented by the world's most ridiculous league.

Opposed: Did you honestly just say "whimsical"? Literally no real person has ever used that word.

In favor: In this fun, irreverent, and fact-filled history, Sean McIndoe relates the flip side to the National Hockey League's storied past.

Opposed: You literally just cut-and-pasted that off the book cover.

In favor: Look man, I spent a year writing this thing. I barely saw my family, I almost went blind squinting at old newspaper clippings, and they've sent me "one last round of edits" like six times in the last month. And after all of that, the whole thing still isn't completely finished because the stupid Golden Knights came along and wrecked one of the last chapters. So help me out here.

Opposed: Sigh. Fine. You do what you have to do.

In favor: Thanks.

Opposed: But can we go back to complaining about instant replay review soon?

In favor: Next week after the Cup-winning goal gets waved off, I promise.

The final verdict: Well gosh, looks like we'll all be getting our Christmas shopping done early this year!

Classic YouTube Clip Breakdown

Today is the first day of June, and there was a time when that meant that the hockey season would have been long over with. Not any more, of course—the playoffs have stretched into June for years now. So today, let's welcome the new month by going back to the first NHL game ever played in June.

It's June 1, 1992 and we're in Chicago for Game 4 of the Stanley Cup Final. The Penguins are up 3-0 in the series and looking for the sweep and for their second straight Cup win. As a side note, they're also looking for the 11th straight win in a single postseason, which would tie the record previously held by [checks notes] the 1992 Blackhawks. Huh. Maybe 1992 wasn't the best year for parity. I'm sure nobody enjoyed it.

Our clip begins with a vaguely weird aside about how the legendary Chicago Stadium will soon be torn down and replaced with a modern arena. The Stadium really was an amazing place to watch hockey, but the weird part is that it wasn't actually replaced for two more years, so the somber tone here feels a little premature.

Speaking of the end of the Chicago Stadium, it was the Maple Leafs who shut it down, and they did it with a 1-0 win. Eat that, Hawks fans. I'm sure nothing has happened in the ensuring quarter-century that you can throw back in my face.

The Blackhawks tie it up a few minutes later, as Dirk Graham cuts across the zone and beats Tom Barrasso. I know that whenever we do these old 80s or early 90s games, we always beat the whole "goaltending was terrible back then" observation into the ground, but go back and rewatch this goal. Graham basically moves from the inside edge of one faceoff circle to the other—like maybe ten feet total—and Barrasso is reduced to having to do a sideways bunny hop to stay with him, then falls down as soon as he makes the first save. And remember, Barrasso was a borderline Hall-of-Famer. This is just how goalies moved back then. In hindsight, it's amazing every game didn't end up being 13-12.

On a related note, the previous game of this final was a 1-0 Penguins win. I'm not sure anything about early 90s hockey made any sense other than Mario Lemieux was good and if you fought Wendel Clark your face would explode. Other than that, you were on your own.

The Penguins come right back a few seconds later with a Kevin Stevens goal. "Ah, look out Loretta." Did I mention that our play-by-play guy here is Mike Lange? You probably figured that part out on your own.

The Stevens goal spells the end for Belfour, which gives us the opportunity to remember that their backup was goofy European weirdo Dominik Hasek, who at this point is 28 and not very good. Two years later he'll win the first of six Vezinas. Seriously, my "early 90s hockey made no sense" theory might be on to something.

Lange is telling us a story about Hasek being drafted in 1983 "when it wasn't real fashionable to draft people," at which point the Blackhawks score to make it 2-2. I know the goal interrupts Lange just as he was going to make a point about drafting Europeans, but I prefer to imagine he had completed his thought and that it was just unfashionable to draft anyone at all in 1983. (For one team, that was actually true.)

The Penguins regain the lead as Lemieux and Hasek perform a short play entitled "What the Nagano shootout should have looked like." But Graham comes right back with his hat trick goal, and we're tied again. At this point we have one of those fun old-hockey-highlights moments where you realize it's still the first period and remember how much fun this sport is when everyone's defensive strategy was "Screw defense, I'd rather score."

It's always fun during a high-scoring highlights package when the guy putting the clips together is like "Oh yeah, I should probably work in one save." In this case it's Lemieux getting a breakaway, only to be robbed by a sprawling Hasek. Maybe scratch that thought about if Mario had been in Nagano. Not because of this save, just because I realized Marc Crawford probably would have had Eric Desjardins shoot instead.

Larry Murphy gives the Pens their fifth lead of the game, and this time they manage to pad it when Ron Francis "beats goaltender Hasek like a rented mule." The good: Mike Lange. The bad: Every play-by-play guy from the next 25 years who convinced himself his catchphrases were as funny as Mike Lange's.

But that's all the Hawks would get, as we cut ahead to the dying seconds. Lange does that wonderful play-by-play thing where he starts in with his "we win" call but then realizes he's a few second early and has to backtrack. But he makes up for it with his all-time classic "Lord Stanley, Lord Stanley, bring me the brandy" call.

Wait, is it me or did he actually say "get me the brandy"? I'm pretty sure he did. This is like finding out that Sherlock Holmes never said "Elementary, my dear Watson" in any of the books. I swear, if it turns out Lange never asked us to sneak up and mutilate him with a hacksaw I'm going to question everything from my childhood.

And that's it for our clip. The Penguins win the Cup, and the season ends just hours into June. And in case you were wondering why the season stretched on so long in 1992, it's because there was a ten-day player strike just before the playoffs. A work stoppage, hockey being played in June, and a Blackhawks/Penguins matchup? Man, no wonder Gary Bettman couldn't wait to get on board a few months later.

Have a question, suggestion, old YouTube clip, or anything else you'd like to see included in this column? Email Sean at [email protected].

DGB Grab Bag: Ovi Face, June Hockey History, and Stop Lying about Start Times published first on https://footballhighlightseurope.tumblr.com/

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