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[email protected] > Subject: Graduate position: UUlm.Two.InsectEvolution > Date: 3 June 2022 at 06:34:18 BST > To:
[email protected] > > > ---- One of Two ---- > > Fully funded PhD position in evolutionary genetics of > Drosophila-transposon interactions at the University of Ulm, Germany. > > Title - FlyInnovation - Are telomere specific retroelements an innovative > solution to the end-replication problem? > > This PhD project in evolutionary insect genetics studies potential > conflict and collaboration between transposons and their Drosophila > hosts. The position is funded for three years as part of the project > FlyInnovation at the University of Ulm, Germany, and is part of the > large interdisciplinary DFG funded Priority Programme GEvol. > > Eukaryotes face a challenge: they must protect coding DNA from getting > shorter with each round of cell replication. Telomeres are a widespread > solution to this challenge. These repetitive DNA motifs cap chromosome > ends and protect coding DNA. Because telomeres and telomerase (the > enzyme that maintains telomeres) are vital to chromosome integrity > they are highly evolutionarily conserved. This makes the Diptera > unusual ' flies have lost telomeric repeats and telomerase. Among > the Diptera, Drosophila are unique: they are the only genus we know of > where transposable elements (TEs) are the sole means of maintaining > chromosome ends. These TEs act like telomerase, extending telomeric > regions by successive transposition. This system has been heralded as > a clear-cut example of TE domestication but evidence in support of this > idea is lacking. We will unite theoretical and empirical approaches to > determine if telomere-specific TEs are an innovative means of preserving > chromosome ends in the absence of telomerase, or selfish genetic elements > avoiding host-silencing in a genomic safe-site. > > This project works alongside a theoretician who will apply methods from > ecology to model the evolutionary dynamics of TEs. This studentship will > test these models, and link TE abundance and diversity to phenotype to > understand if TEs and hosts are cooperating, or in conflict. This will > involve large scale laboratory experimentation with multiple insect > species, molecular analyses (qPCRs, preparing samples for sequencing) > and cytological analyses (oligopainting and Fluorescence in Situ > Hybridization). The project will also entail analyzing molecular data > and phylogenetic analyses. > > This PhD studentship is part of a collaborative project with Dr. Pete > Czuppon (University of M�nster), working within the DFG funded > Priority Programme GEvol. The goal of GEvol is to collaboratively and > interdisciplinarily exploit new computational and OMICS methods to reveal > the history of genomes in the insect taxon by comparative genomics. At > the institute of Evolutionary Ecology and Conservation Genomics, an > interactive and international team studies diverse topics in evolutionary > ecology, including host-pathogen interactions (Prof. Wilfert), insect > evolutionary genetics and metabolomics (Dr. Ruth Archer), conservation > genomics (Prof. Sommer) and pollinator ecology (Profs. Ayasse and > Tschapka), with the possibility to collaborate with Prof. Niessing > (Institute of Pharmaceutical Biotechnology) on FISH analysis. > > Applicants will possess a relevant Master degree in evolutionary > biology or a related field of study. The successful applicant should > have expertise in the fields of evolutionary ecology, genetics or > evolutionary genomics. Applicants should ideally have expertise in > experimental quantitative genetics, molecular techniques and/or > bioinformatics. Experience in working with live insects would be > desirable. The successful applicant will be able to work autonomously > but also collaboratively and will have excellent oral and written English > language skills. > > The position will be based at the University of Ulm, at the Institute > of Evolutionary Ecology and Conservation Genomics. Ulm is a delightful > historic city on the Danube in Southwestern Germany; it is one hour > from the Alps, Lake Constance, Munich and Stuttgart. Additionally, the > position includes work in partner labs in Cologne, Freiburg and Hannover. > > For further information, please contact Prof. Lena > Wilfert (
[email protected]) or Dr. Ruth Archer > (
[email protected]). The closing date is the 27th of June > 2022. Applications should include a cover letter describing your > motivation and research interest, a CV and digital copy of your > MSc/Diploma certificates and transcript of records. The job advert with > detailed information on profile and responsibilities, as well as the > link to the online application system can be found here (reference 22078) > https://ift.tt/c5NtO4K > Please note that applications have to be processed online! > > Prof. Dr. Lena Wilfert > University of Ulm > Institute of Evolutionary Ecology and Conservation Genomics > Albert-Einstein Allee 11 > D-89069 Ulm > Germany > Tel.: 0049-731-5030615 > Fax: 0049-731-5022683 > > email:
[email protected] > Website: > https://ift.tt/QbxcWFq > > Lena Wilfert Ulm > > > ---- Two of Two ---- > > > > Fully funded PhD position in evolutionary genomics of insect immunity > at the University of Ulm, Germany. > > Title: ImmuNov - Genomics and epigenomics of immune innovations in > insects. > > We are recruiting a PhD student to study the evolution of innate > immunity in insects. The project involves comparative analysis of > the gene expression response (i.e. transcriptomics) of several insect > species against generalist pathogens, and of the epigenetic regulation > of immunity. The focus will be on genetic novelty and understanding how > and how often new genes emerged and acquired an immune function in the > evolutionary history of insects. > > The student will join a dynamic team (including four postdocs and three > PhD students) led by Prof. Lena Wilfert, working on different aspect of > insect disease ecology and evolutionary biology. Moreover, this project > will be part of a multi-team program across Germany focusing on genetic > innovation in insects (http://www.g-evol.com). The goal of the DFG funded > Priority Programme GEvol is to collaboratively and interdisciplinarily > exploit new computational and OMICS methods to reveal the history of > genomes in the insect taxon by comparative genomics. This priority > project offers excellent opportunities for collaboration and networking > with leading institutes in evolutionary biology, in addition to planned > collaborations with Prof. Siegfried Roth (Uni Koln), Prof. Stefanie Becker > (TiHo Hannover) and Prof. Judith Korb (Uni Freiburg). The position is > for 3 years (salary scale TV-L 13, 65%), with a preferred starting date > in October 2022. > > The post will include experimental infections of diverse insect species > and the use of multi-OMICs approaches to reveal gene expression, and > the analysis of molecular evolution and regulation of immune genes by > comparative genomics. The successful applicant will be able to develop > research objectives, contribute to the process of securing funds and > make presentations at conferences and other events. > > Applicants will possess a relevant Master degree in evolutionary > biology or a related field of study. The successful applicant should > have expertise in the fields of molecular biology or evolutionary > genomics. Applicants should ideally have expertise in molecular > techniques, experimental pathology and/or bioinformatics. Experience in > working with live insects would be desirable. The successful applicant > will be able to work autonomously but also collaboratively and will have > excellent oral and written English language skills. > > The position will be based at the University of Ulm, at the Institute > of Evolutionary Ecology and Conservation Genomics. Ulm is a delightful > historic city on the Danube in Southwestern Germany; it is one hour > from the Alps, Lake Constance, Munich and Stuttgart. Additionally, the > position includes work in partner labs in Cologne, Freiburg and Hannover. > > For further information, please contact Dr. Vincent Doublet >
[email protected]. The closing date is the 27th of June > 2022. Applications should include a cover letter describing your > motivation and research interest, a CV and digital copy of your > MSc/Diploma certificates and transcript of records. The job advert with > detailed information on profile and responsibilities, as well as the > link to the online application system can be found here (reference 22079) > [https://ift.tt/FRl7P9a]. > Please only apply via the online system. > > > > > Prof. Dr. Lena Wilfert > University of Ulm > Institute of Evolutionary Ecology and Conservation Genomics > Albert-Einstein Allee 11 > D-89069 Ulm > Germany > Tel.: 0049-731-5030615 > Fax: 0049-731-5022683 > > email:
[email protected] > Website: > https://ift.tt/QbxcWFq > >
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