#forkhead

[tianjinwellmadescaffold]

Fixed Fork Head - Wellmade Scaffold, China - Slab and Beam Formwork Top ...

[pitchforkhead]

Sometimes I just feel like Alex Trimble's Gameshow Era. I mean long ginger hair and cool leather jacket. I need to be like him right now. I need to be in the Gameshow Era.

[jessica-problems]

inventing new lesbians

[pitchforkhead]

Literally how I look like every morning...

Tagging @heyjudelaw @photoshopbazball @airbrushfather <3

was tagged by @rosetintedgreyspaces in this picrew chain. thanks lovely :)

(here is the link to the picrew by baby_carrot_art)

i made two versions :•)

this one is so cute, i love all the options

no pressure tags; @michameinmicha @is-this-taken-too-questionmark @capitaen @sillygooseness @lalalenii @padmedala

[gemstone-gynoid]

I like that darumi during free time events makes your character play porn games with her. What are we playing? Meet n fuck kingdom? Forkheads sex kitten sim date? Mario is missing? She says it's some fucked up stuff. That's a choice of a introduction topic for someone you meet just 1 hour ago.

[versza1]

Manure Fork Heads for Sale – Easy Replacement & Installation

Now, instead of replacing the entire tool, you can get easy replacement manure fork heads with Versza. Click here to read how we offer the best forkhead globally.

[moleculardepot]

Rabbit Polyclonal FOXA2 Antibody (Human)

Rabbit Polyclonal FOXA2 Antibody (Human) Catalog number: B2022922 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 100 uL Molecular Weight or Concentration: 48.306 kDa Supplied as: Liquid Applications: a molecular tool for various biochemical applications Storage: -20°C Keywords: Rabbit Polyclonal Forkhead Box Protein A2 Antibody, Rabbit Anti-FOXA2 Antibody, Rabbit…

[twinkl22004]

“T-cell Leukemia Virus Enhancer”, Victor McKusick, Mendelian Inheritance in Man, 1966. T细胞白血病病毒增强剂。

Here I present: “T-cell Leukemia Virus Enhancer”, Victor McKusick, Mendelian Inheritance in Man’, 1966. T细胞白血病病毒增强剂。 INTRODUCTION. Adult T-cell leukemia (ATL) is a cancer of the immune system’s T-cells caused by human T cell leukemia virus type-1 (HTLV-1). FOXN2 belongs to class 2 of the forkhead box (FOX) family of transcription factors, members of which lack a basic region at the C-terminal end…

[theraplus32]

TheraPlus™: Body Massager Gun for Ultimate Muscle Relief

If you're seeking to elevate your recovery routine, the TheraPlus™ Body Massager Gun offers the perfect solution. Whether you're an athlete aiming to reduce post-workout muscle soreness or an office worker dealing with neck and back pain from long hours of sitting, this muscle massage gun is designed to help you feel your best.

Why Choose TheraPlus™

TheraPlus™ is not just another muscle massage gun—it’s designed with cutting-edge technology to deliver deep tissue massage that targets every sore spot with precision. Let’s explore some of the key features that make this body massager gun the go-to choice for muscle relief:

Deep Muscle Relief with 30 Adjustable Speed Levels

The TheraPlus™ Muscle Massage Gun is equipped with 30 speed levels, allowing you to adjust the intensity to meet your specific needs. From gentle relaxation to deep tissue therapy, this device promotes blood flow, speeds up muscle recovery, and helps alleviate muscle stiffness and soreness.

Six Versatile Massage Heads for Targeted Relief

TheraPlus™ ensures a comprehensive massage experience with six different massage heads. Each one is designed to focus on a specific area of the body, ensuring optimal relief:

Forkhead for spinal areas, Flathead for large muscle groups, Bullethead for deep tissue, Round head for overall body relaxation, and two more specialized heads for precision work. Whether it's your neck, shoulders, back, or legs, this device offers a tailored massage experience every time.

HD LCD Touch Display for Easy Operation

Controlling your massage is a breeze with the HD LCD touchscreen. The display gives you real-time information on the speed, battery level, and operational status, ensuring you have full control over your session.

Quick Charging and Long Battery Life

The TheraPlus™ Muscle Massage Gun is powered by a long-lasting lithium battery, offering up to 3 hours of continuous use on a single charge. Whether you're at home, at the gym, or traveling, the quick charging feature ensures you're never without your massage gun for too long.

How to Use TheraPlus™ for Maximum Results

Choose the Right Attachment: Select the attachment that suits your target area. Adjust the Speed: Start with a lower speed setting and gradually increase intensity as needed. Apply in a Circular Motion: Gently press the massage gun against the sore area and move it in circular motions to ensure even muscle relief. Focus on Problem Areas**: Spend extra time on particularly tense spots, but avoid holding the gun in one spot for too long to prevent overstimulation.

With TheraPlus™ Body Massager Gun, muscle soreness and tension will no longer stand in the way of your daily life. Whether you're recovering from a workout or seeking relief from daily stress, TheraPlus™ offers a convenient, effective, and soothing solution.

[crimsonpublishersobesityjourna]

The Metabolic Syndrome Diseases – Interventions Using Micronutrients

Metabolic Syndrome is defined as a cluster of interrelated conditions such as central obesity, dyslipidemia, impaired glucose metabolism and hypertension [1]. In addition to genetic predisposition as in South Asians, a sedentary lifestyle and a high caloric intake contribute to the development of this cluster of metabolic conditions. The worldwide increase in the incidence of this condition has made it a global epidemic. The recent Finnish study [2] attests to the decrease in incidence of Type 1 diabetes following fortification of dietary milk products with cholecalciferol. Insulin resistance and central obesity standout as the common feature of this cluster of conditions. The binding of insulin-to-insulin receptor (IR) results in the dimerization of the alpha and beta subunits and auto phosphorylation of the beta subunit leading to the activation of the Ras – MAPK and PI3K – Akt signaling cascades. The activation of PI3K associated with insulin receptors IRS1 and IRS2 results in the phosphorylation Akt-Foxo1 and is central to the control of nutrient homeostasis. The inactivation of Akt – Foxo1 pathway with the resulting activation of the forkhead/winged helix family transcription factor through suppression of IRS1 and IRS2 in organs following hyperinsulinemia, are suggested to be key mechanisms in the development of the metabolic syndrome. Hence, targeting the IRS – Akt – Foxo1 signaling cascade will provide a therapeutic approach for the treatment of the metabolic syndrome cluster of conditions. The activation of Akt affects cell survival and energy homeostasis by increasing glycogen synthetase activity, decreasing gluconeogenesis, promoting hepatic lipogenesis and cardiac cell survival. These phosphorylation-mediated cell events are the result of insulin signaling in various cells and tissues. Insulin is at the centre of adaptive metabolic transition in insulin-responsive tissues. Hyperinsulinemia inhibits the acute action of insulin on Foxo1 phosphorylation as well as transcription of IRS2 gene in insulin-responsive tissues.

Read more about this article: https://crimsonpublishers.com/iod/fulltext/IOD.000625.php

Read more about our journal: https://crimsonpublishers.com/iod/

[biotech-news-feed]

Orphan designation: Autologous induced pluripotent stem cells-derived thymic epithelial cells transduced with a lentiviral vector encoding forkhead box protein N1 Treatment of DiGeorge syndrome, 24/05/2024 Positive #BioTech #science

[tianjinwellmadescaffold]

Adjustable Four Way Head - Wellmade Scaffold - Fork Head Jacks

[pitchforkhead]

Best purchase of my whole life.

[rnomics]

Antioxidants, Vol. 13, Pages 1004: Sodium Selenite Induces Autophagy and Apoptosis in Cervical #cancer Cells via Mitochondrial ROS-Activated AMPK/mTOR/FOXO3a Pathway

Selenium (Se) is an essential trace element known for its significant role in maintaining human health and mitigating disease progression. Selenium and its compounds exhibit high selective cytotoxicity against tumor cells. However, their anti-cervical #cancer (CC) effects and underlying mechanisms have not been fully explored. This study found that sodium selenite (SS) inhibits the viability of HeLa and SiHa cells in a dose- and time-dependent manner. Intraperitoneal injection of 3 and 6 mg/kg SS for 14 days in female nude mice significantly inhibited the growth of HeLa cell xenografts without evident hepatotoxicity or nephrotoxicity. #RNA sequencing results indicated that the AMP-activated protein kinase (AMPK), Forkhead box protein O (FOXO), and apoptosis signaling pathways are key regulatory pathways in SS&rsquo;s anti-CC effects, and SS&rsquo;s inhibition of HeLa cell proliferation may be related to autophagy and ROS-induced apoptosis. Further research has revealed that SS induces cell autophagy and apoptosis through the AMPK/mTOR/FOXO3a pathway, characterized by the upregulation of p-AMPK/AMPK, FOXO3a, LC3-II, cleaved-caspase3, and cleaved-PARP and the downregulation of p-mTOR/mTOR and p62. Additionally, SS impaired mitochondrial function, including decreased mitochondrial membrane potential, mitochondrial Ca2+ overload, and accumulation of mitochondrial reactive oxygen species (mtROS). Pretreatment with Mitoquinone mesylate (Mito Q) and compound C partially reversed SS-induced apoptosis, autophagy, and proliferation inhibition. Pretreatment with 3-methyladenine (3-MA) enhances SS-induced apoptosis and proliferation inhibition in HeLa cells but reverses these effects in SiHa cells. In summary, SS induces apoptosis, autophagy, and proliferation inhibition in HeLa and SiHa cells through the activation of the AMPK/mTOR/FOXO3a signaling pathway via mtROS. Autophagy activation may be a major risk factor for SS-induced apoptosis in SiHa cells but can protect HeLa cells from SS-induced apoptosis. These findings provide new evidence for understanding the molecular mechanisms underlying SS in potential new drug development for CC. https://www.mdpi.com/2076-3921/13/8/1004?utm_source=dlvr.it&utm_medium=tumblr

[tavie]

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A post shared by Tavie Phillips (@taviep)

Forkheads

[dorpeer91]

Forkhead!

Quick digital cartoon-y illustration I did, based on an old sketch.

Soooort of a self portrait but not really