#ib recruitment 2020

[poonamranius]

Sarkari naukari IB Recruitment 2022: खुफिया विभाग में इन पदों पर निकली है बंपर वैकेंसी, लाखों में है सैलरी, जल्द करें अप्लाई

Sarkari naukari IB Recruitment 2022: खुफिया विभाग में इन पदों पर निकली है बंपर वैकेंसी, लाखों में है सैलरी, जल्द करें अप्लाई

IB Recruitment 2022: यदि आप सरकारी नौकरी की तलाश कर रहे हैं, तो आपके लिए ये काम की खबर है। आपके सरकारी जॉब पाने का सपना साकार हो सकता है। IB Recruitment 2022: यदि आप सरकारी नौकरी की तलाश कर रहे हैं, तो आपके लिए ये काम की खबर है। आपके सरकारी जॉब पाने का सपना साकार हो सकता है। आपको सरकारी नौकरी मिल सकती है। आपके सपने पूरे हो सकते हैं। इंटेलिजेंस ब्यूरो में नौकरी की तलाश कर रहे युवाओं के लिए…

[prassi9866]

Intelligence Bureau ACIO Recruitment 2021 Apply Online for 2000 Vacancy in IB

Intelligence Bureau ACIO Recruitment 2021 Apply Online for 2000 Vacancy in IB

INTELLIGENCE BUREAU (Ministry of Home Affairs) Government of India ASSISTANT CENTRAL INTELLIGENCE OFFICER-GRADE-II/ EXECUTIVE EXAMINATION- 2020 Intelligence Bureau (IB) has published notification for the recruitment of Assistant Central Intelligence Officer (ACIO) – Grade-II/ Executive Examination 2020. Those Candidates who are interested in the following vacancy and completed all Eligibility…

[avisionadmin]

[vilaspatelvlogs]

LIVE Sarkari Naukri 2020: हाईकोर्ट, रेलवे, LIC, नीति आयोग समेत कई जगहों पर नौकरियां, तुरंत करें आवेदन

LIVE Sarkari Naukri 2020: हाईकोर्ट, रेलवे, LIC, नीति आयोग समेत कई जगहों पर नौकरियां, तुरंत करें आवेदन

पढ़ें अमर उजाला ई-पेपर कहीं भी, कभी भी। *Yearly subscription for just ₹299 Limited Period Offer. HURRY UP! खास बातें Live: Sarkari Naukri 2020 Updates: क्या सिर्फ मेहनत करने से सरकारी नौकरी करने का सपना पूरा हो सकता है? नहीं, इसके लिए जरूरी है सही सूझ-बूझ भी। नौकरी के लिए अब आपको महीनों इंतजार करने की जरूरत नहीं है। लाइव ब्लॉग आपको लेटेस्ट भर्तियों से अपडेट रखेगा। बता दें कि हम amarujala.com पर…

[latestbreakingnewsupdates]

IB ACIO Recruitment: Intelligence Bureau has released the ACIO Recruitment Notification, Learn Special Things About IB ACIO Recruitment

IB ACIO Recruitment: Intelligence Bureau has released the ACIO Recruitment Notification, Learn Special Things About IB ACIO Recruitment

Intelligence Bureau Assistant Central Intelligence Officer Appointment 2020: Intelligence Bureau has issued notification for IB-IB Assistant Assistant Central Intelligence Officer – Grade-2 / Executive Examination 2020 {IB ACIO Recruitment 2020 for. Those who want to appoint Assistant Central Intelligence Officer posts in IB under the Ministry of Home Affairs. The last date is 09 January 2021. By…

[newzzhub]

IB Assistant Central Intelligence Officer/ Executive Exam 2020 Details Released

IB Assistant Central Intelligence Officer/ Executive Exam 2020 Details Released

IB ACIO 2020 recruitment begins New Delhi: The Intelligence Bureau, Ministry of Home Affairs has invited applications for direct recruitment to the post of Assistant Central Intelligence Officer, Grade II/ Executive. This is a General Central Service, Group ‘C’ (Non-Gazetted, Non-Ministerial) post. The pay scale for this post is Rs 44900-142400. There will be a special security allowance which…

[theexampur]

Ministry of Home Affairs (MHA) has recently announced the official recruitment of 2020-2021 for the vacancies of 2000 Assistant Central Intelligence Officer Grade-2 and executives.

[kuldeepsonimp]

ASSISTANT CENTRAL INTELLIGENCE OFFICER-GRADE-II/EXECUTIVE EXAMINATION-2020

फार्म भरने की तिथि 19.12.2020

आयु फिस एवं आई.बी से संबधिज जानकारी के लिये Click करें

[phgq]

NegOr studes told to shun illegal drugs, terrorism 

#PHinfo: NegOr studes told to shun illegal drugs, terrorism 

NEGROS ORIENTAL, March 5 (PIA) -- Philippine Army troopers of the 302nd Infantry Brigade (IB) continue to visit schools to advise students to avoid illegal drugs and stay away from terrorism.

The ‘Achiever Troopers’ led by Brigade Commander Col. Noel Baluyan of the 302nd IB cautioned the nearly 500 students including teachers of Diaz College in Tanjay City against the harmful effects of illegal drugs and terrorism. 

The Anti-Illegal Drugs and Anti-Terrorism symposium held Tuesday was conducted through the Tanjay City Advisory Council.

It aimed to heighten awareness on the current situation of illegal drugs and orient the students on the insurgent exploitation and other destructive influence/activities of the Communist Party of the Philippines-New People's Army- National Democratic Front (CPP-NPA-NDF). 

A Philippine Army officer distributing Information, Education and Communication (EIC) materials on anti-insurgency during the symposium at Diaz College in Tanjay City. (KT/PIA Negros Oriental)

According to Capt. Khadaffy Tawantawan, information officer designate of 302nd IB, the activity intends to isolate the youth from the deceptive recruitment strategy of the communist terrorist groups.

This is also to enable the students to make the right choices and encourage more open communication between parents and children, said Tawantawan.

He warned students about the recruitment activities being done by CPP-NPA in schools.

Baluyan also encouraged the students to help the government in ending the insurgency.

“I urge you, as students and youth of this country, to be vigilant and be discerning in joining organizations in your school. This is because the CPP-NPA-NDF has mastered the art of deception," he said. 

The Philippine Army official asked the students to be wary of the organizations they are joining since some will only deceive them by filling their minds with hatred and violence.

He also encouraged the students to support Executive Order No. 70 and be part of the country's journey towards achieving genuine peace and development. (jct/PIA7 Negros Oriental)

***

References:

* Philippine Information Agency. "NegOr studes told to shun illegal drugs, terrorism ." Philippine Information Agency. https://pia.gov.ph/news/articles/1035748 (accessed March 05, 2020 at 05:31PM UTC+08).

* Philippine Infornation Agency. "NegOr studes told to shun illegal drugs, terrorism ." Archive Today. https://archive.ph/?run=1&url=https://pia.gov.ph/news/articles/1035748 (archived).

[mr-entj]

I'm in a bit of a situation at work and I was hoping you could give me some advice. I'm a rising junior in college and I've been working at a wall street firm (back-office) as a wealth management intern for the past year (during school and this summer). I took the job honestly because I thought a big name would give me more financial experience because I ultimately want to do investment banking. I've gotten some experience but I know I don't want to do Wealth Management full time. (1/2)

(2/2): My boss has been telling me he expects me to work for them till I graduate (2 more years). But all the 2020 IB internships require me to apply NOW and I don’t want to do anything sketchy. I was thinking of telling him I just need Summer 2020 off, but I know I can’t be working for 2 banks at the same time. I have no idea what to do. I don’t want to just leave on bad terms, but I don’t want to miss my chance at an IB internship and be forced to stay here forever. What should I do?

Recruit, interview, and secure an investment banking internship first– then open a conversation with your boss about transitioning out of wealth management. If you get the IB internship– leave. If you don’t get the IB internship– don’t bring it up with your boss and retry next summer. This ensures you have all bases covered with minimal risk to your career.

Remember that you’re an intern– not an indentured servant– and you’re free to leave a job at any time by giving a standard 2-week notice. No one is obligated to be chained to any position for any amount of time (assuming you didn’t sign an employment contract that stipulated that). He’s not going to swear bloody vengeance on your family for leaving an internship and wage professional warfare to wreck your career. Like most people, he’ll be unhappy for a bit, then move on.

[sabkuchgyan]

इंटेलिजेंस ब्यूरो नौकरी के लिए करने ऑफलाइन आवेदन... जल्दी

इंटेलिजेंस ब्यूरो नौकरी के लिए करने ऑफलाइन आवेदन जल्दी #IntelligenceBureau #IB #Jobs

IB Recruitment 2020: इंटेलिजेंस ब्यूरो (Intelligence Bureau) – गृह मंत्रालय योग्य उम्मीदवारों से ऑफ़लाइन मोड के माध्यम से आवेदन आमंत्रित करता है ताकि अवशोषण / प्रतिनियुक्ति के आधार पर 292 उम्मीदवारों को संलग्न किया जा सके। जो आवेदक केंद्रीय सरकार में इंजीनियरिंग की नौकरी की तलाश कर रहे हैं, वे भी इस अवसर का उपयोग कर सकते हैं। योग्य आवेदक दिए गए आवेदन पत्र को दिए गए पते पर इस परिपत्र के जारी होने…

[rupeerains]

IB Recruitment 2020 -Deputy Director/ Tech posts.

IB Recruitment 2020 -Deputy Director/ Tech posts.

IB Recruitment 2020 -Deputy Director/ Tech posts.

Intelligence Bureau has published an advertisement to  fill up vacancies in the following ranks in the Intelligence Bureau under the Ministry of Home Affairs on absorption/deputation (including short term contract basis) as mentioned below.

The educational qualifications, experience and other eligibility conditions for the post in advertisement…

[newswriteronline]

ஐபி ஆட்சேர்ப்பு 2020: செக்யூரிட்டி ஆபிசர், ஆராய்ச்சி உதவியாளர் வேலை.. ஒரு லட்சம் வரை சம்பளம் | IB Recruitment 2020: how to apply 292 Vacancies for Security Officer, Research Assistant and Other Posts

ஐபி ஆட்சேர்ப்பு 2020: செக்யூரிட்டி ஆபிசர், ஆராய்ச்சி உதவியாளர் வேலை.. ஒரு லட்சம் வரை சம்பளம் | IB Recruitment 2020: how to apply 292 Vacancies for Security Officer, Research Assistant and Other Posts

Jobs oi-Velmurugan P Published: Thursday, July 16, 2020, 12:57 [IST] டெல்லி: ஐபி ஆட்சேர்ப்பு 2020: உள்துறை அமைச்சகத்தின் கீழ் பாதுகாப்பு அதிகாரி, ஆராய்ச்சி உதவியாளர் மற்றும் பிற பணியிடங்களுக்கு தகுதியும் விருப்பமும் உள்ளவர்கள் விண்ணப்பிக்கலாம் என புலானய்வு அமைப்பு (ஐபி) அழைப்பு விடுத்துள்ளது. தகுதி மற்றும் விருப்பம் உள்ளவர்கள் வரும் செப்டம்பர் 18ம் தேதிக்குள் விண்ணப்பிக்க வேண்டும். ஐபி…

[nuadox]

Whole-genome database will help refine diagnosis of genetic diseases in Brazil

- By Elton Alisson , Agência FAPESP -

A database containing whole-genome sequences for elderly inhabitants of São Paulo City in Brazil, developed by researchers affiliated with the Human Genome and Stem-Cell Research Center (HUG-CELL) at the University of São Paulo’s Institute of Biosciences (IB-USP), will be used to detect mutations that are responsible for genetic diseases found in the Brazilian population or that play a key role in healthy aging.

Datasets for individuals are already available to the scientific community for downloading on request, and aggregate data has been posted in recent years to the Online Archive of Brazilian Mutations (ABraOM). 

An analysis of the genomic data is reported in an article just published in Nature Communications.

A paper with preliminary results was posted in 2020 to bioRxiv, a preprint platform for articles on the biological sciences that have not yet been peer-reviewed (more at: agencia.fapesp.br/34628). 

“Since the data began to be made available, many researchers in Brazil and abroad have accessed the repository, demonstrating the importance of this initiative to the scientific community,” Mayana Zatz, a professor at IB-USP, told Agência FAPESP. Zatz is principal investigator at HUG-CELL, a Research, Innovation and Dissemination Center (RIDC) funded by FAPESP.

The database resulted from a groundbreaking whole-genome sequencing study of 1,171 elderly Brazilians, representing Latin America’s largest cohort for research on the DNA of older people.

Originally called Projeto 80mais, the research began in 2008 with a project to characterize the genomes of physically and cognitively healthy seniors, establish a genomic reference database for the Brazilian population, and contribute to a deeper understanding of the factors involved in healthy aging.

The subjects in this study had an average age of 71 and were unrelated. They were selected by researchers at the University of São Paulo’s School of Public Health (FSP-USP) from the cohort recruited for the longitudinal study of Health, Wellbeing and Aging (Saúde, Bem-estar e Envelhecimento, SABE), which is supported by FAPESP.

SABE began in 2000, with Maria Lúcia Lebrão and Yeda Duarte as principal investigators. Both are professors at FSP-USP. 

SABE investigates the health and living conditions of people aged 60 and over in São Paulo and six other cities of Latin America and the Caribbean via interviews, assessments, and medical examinations. “The study is representative of the elderly population of São Paulo because it’s based on the municipal census of the city and includes people in all income groups,” Zatz said.

Highly mixed population

The subjects were selected for whole-genome sequencing because they had passed the age at which clinical manifestations of several aging-related diseases such as Alzheimer’s and Parkinson’s typically begin.

Because they live in São Paulo, Brazil’s largest city, they also represent the genetic diversity of the Brazilian population, which is highly mixed in terms of ethnicity and ancestry, Zatz explained. “São Paulo’s population is the most admixed of any Brazilian city,” she said. “It includes many descendants of immigrants from different continents, such as Europe, Asia and Africa, as well as natives of other states and countries.”

The considerable genetic diversity of the study sample contrasts with the coverage of international genomic databases, which is predominantly European. The research identified some 2 million genetic variants never before described in major public databases, for example.

“This has to do with the fact that the coverage of international databases mainly reflects the European reference genome. This number of novel genetic variants we found, in the range of 2 million, may decrease as the other big repositories begin to include under-represented populations like Brazil’s,” said Michel Naslavsky, a professor at IB-USP and first author of the article.

More diversity in international genomic databases will also improve the accuracy of genetic tests for populations as highly mixed as Brazil’s and those of other Latin American countries, the authors argue.

Analysis of the elderly people’s genomes in the Brazilian database shows that they carry genetic variants classified in European databases as pathogenic but do not manifest the diseases associated with these mutations. “One of the hypotheses we’re raising to explain this is that genetic variants hitherto classified as pathogenic may be expressed differently according to whether the individual’s genetic background is European or of mixed ancestry, for example,” Naslavsky said.

The researchers also found the subjects in the study to be bearers of variants associated with recessive disorders frequently seen in both Europeans and Africans, such as cystic fibrosis. The frequency of heterozygous individuals (people with a recessive variant) can be used to estimate the incidence of these disorders in the population. “In the case of the Brazilian population, we reckon the incidence of cystic fibrosis is one per 10,000 births,” Zatz said. “This information is very important to public programs of genetic counseling for couples of reproductive age on the risks of having children with severe genetic diseases.”

Analysis of the seniors’ genomes also enabled the researchers to detect novel variants of genes in the human leukocyte antigen (HLA) complex, which encodes proteins responsible for permitting the recognition of pathogens and regulating the immune system. These genes are known to be the most variable and diverse of all in the human genome and hence hard to analyze.

Using a special technique, they located more than 140 alleles from HLA genes never described before. Findings such as this are germane to studies on susceptibility or resistance to infection by a wide array of pathogens, including SARS-CoV-2.

The article “Whole-genome sequencing of 1,171 elderly admixed individuals from São Paulo, Brazil” is at: www.nature.com/articles/s41467-022-28648-3.

 This text was originally published by FAPESP Agency according to Creative Commons license CC-BY-NC-ND. Read the original here.

--

Read Also

Scientists believe they have sequenced the entire human genome

[joyfuldelusionchaosvaliant]

Science and Chemistry Classes

Treatment with injections of Zika virus destroys brain tumors in mice without causing neurological damage

by FAPESP

12/01/2022

In a study conducted at the University of São Paulo's Human Genome and Stem Cell Research Center (HUG-CELL) in Brazil, serial systemic injections of Zika virus into mice with brain tumors destroyed the cancer without causing neurological damage or injuring other organs, and increased the animals' survival rate.

The scientists also injected Zika into cerebral organoids, brain-like organs created in vitro using stem cells. The virus not only prevented progression of the tumors but actually reduced their size.

In both the mice and the organoids, cytokines (proteins that regulate the immune response) suppressed tumor growth after treatment, and defense cells migrated to the brain region affected by the tumor, alerting the immune system to its existence.

These results, reported in an article published in a special issue of the journal Viruses, confirm the efficacy and safety of treatment with Zika in both models, opening up prospects for the use of virotherapy to treat central nervous system tumors.

Some 11,000 new cases of brain cancer were registered in Brazil in 2020, of which about 5,200 were in women, according to the National Cancer Institute (INCA).

"One of the key points, confirming previous research, was recruitment of the immune system, which assured a good response to the treatment. Both viral action pathways are very important, enabling the virus to act on a larger number of tumors than we initially foresaw," said Mayana Zatz, a professor at the Institute of Biosciences (IB-USP) and principal investigator for HUG-CELL, a Research, Innovation and Dissemination Center (RIDC) funded by FAPESP.

Zatz is last author of the article, having led the project with co-authors Carolini Kaid, a researcher with a postdoctoral scholarship from FAPESP, and Oswaldo Keith Okamoto, also a professor at IB-USP.

Scientists at HUG-CELL had already shown that Zika virus can infect and destroy central nervous system tumor cells in a study involving mice published in 2018, and a study involving dogs published in 2020. They were the first to discover that Brazilian Zika can be an effective agent to treat aggressive forms of embryonal central nervous system tumors, including medulloblastoma. The therapies available for these tumors, which usually manifest in children, are rarely effective and have severe side effects, impairing the patient's quality of life.

This latest study confirms that the approach is safe and efficacious. "In any attempt at treatment, you need to know the dosage and administration route. In our study, three doses of systemic intraperitoneal injections of Zika at seven-day intervals produced promising results in the models," said Raiane Ferreira, first author of the article. Ferreira has a doctoral scholarship from FAPESP.

FAPESP also supported the research via a scholarship awarded to Rodolfo Sanches Ferreira.

An epidemic of Zika fever began in Brazil and affected other countries in the Americas from April 2015 to November 2016. Most of the cases occurred in Brazil, partly owing to the widespread presence of the mosquito Aedes aegypti, which transmits both Zika and dengue.

Although Zika is usually asymptomatic, research has shown a link between this disease and the development of neurological complications such as Guillain-Barré syndrome and meningitis in adults, and congenital malformations such as microcephaly in newborns.

A significant number of women infected by Zika had babies with congenital Zika syndrome, mostly in the Northeast region. According to the Brazilian Ministry of Health, 3,423 babies were born with the syndrome between 2015 and 2020.

Zatz collected genetic material on a visit to the Northeast when the group was starting their research. "Neural progenitor cells contribute to the formation of the brain and central nervous system. We collected samples from discordant twins, only one of whom had microcephaly. We bred cell lines from these progenitors in the lab. We then infected them with Zika to find out how the virus behaved. That led to the idea of testing it on brain tumors, which are rich in this type of cell," Zatz recalled.

The study

The researchers worked with BALB/c nude mice, a type of laboratory animal that is hairless, lacks a normal thymus gland, and has a defective immune system because of a genetic mutation. In particular, nude mice are deficient in T lymphocytes and are often used in cancer research because they do not reject tumor cells.

The viral load per inoculation was 2,000 plaque-forming units (PFU) of Zika. The first step was to analyze the safety of the treatment by applying the virus directly to the brains of the tumor-bearing animals. The effect was positive, but tumor growth resumed after 21 days.

The researchers then tested serial intracerebroventricular (ICV) injections in mice infected with the same viral load, which displayed high virulence and viremia, losing a significant amount of weight and surviving for only four weeks. The control group remained alive and well, without clinical changes.

Next, they injected three doses of the virus intraperitoneally, with the same intervals between doses. The effects were positive: the mice continued to feed and lost no weight, maintaining good clinical conditions.

In an experiment designed to analyze the tropism of Zika virus, i.e., its preference for infecting a particular tissue, determined in part by interaction with receptors in the brain or tumor, the scientists injected tumor cells into the flank of each mouse and found that the virus did not interact with them. No tumor remission was observed, suggesting that Zika interacted preferentially with the central nervous system.

"Once we had confirmed that the treatment was safe and that viral tropism focused on the brain, we began the three intraperitoneal injections at seven-day intervals and observed the results," Ferreira said.

In the case of brain tumors, the serial injections efficiently destroyed them without neurological damage or injury to other organs, while also extending survival time.

Brain organoids were early-stage (26 days) and infected with Zika at 2,000 PFU seven days after tumor cell addition. The tumor cells rapidly attached and started to spread in the organoids. The outcome was that viral infection of the tumor cells halted progression of the disease, confirming Zika's intense oncolytic effect. An oncolytic virus infects and breaks down cancer cells but not normal cells.

Similarly positive results were obtained with embryonal central nervous system tumor cells, but the authors of the article note that more investigation is required to confirm the selectivity of the virus in these cases.

New stage

According to Zatz, a new stage of the research has now begun, involving the recruitment of dogs with brain tumors. The proposal is to work with animals of different breeds and sizes. "Dogs are extremely important models before we start thinking of tests involving human patients," she said. "They have tumors that closely resemble human tumors and a preserved immune system. It will be possible to analyze different types of tumor."