#macrocephalous

[postpunkindustrial]

Macrocephalous Compost II°

Macrocephalous Compost II° was the second of a three video series compiling a pretty good overview of the more harsh noise/ experimental /dark ambient/ abd what have you at the time.

Artists incude C.C.C.C., Konstructavists, Atrax Mourge, raison d'être, Black Leather Jesus, Aube and more bringing you all the best transgressive imagry of 1995.

After reading off those names You should know what you are in for but keep in mind there are some heavy strobe effects going on at times.

This is a rip from a DVR with .VOB files and menus and everything.

Get it from my Google Drive HERE.

[bemusedlybespectacled]

So, I have an absolutely enormous head. Like, 99th-percentile-for-adult-women, can't-wear-normal-hats-or-bike-helmets-or-headbands-because-they-physically-do-not-fit-on-my-massive-noggin kind of enormous. Average head circumference for an adult woman is somewhere between 21-22 inches (55 cm), mine is around 23.5 (~60 cm).

So, I think to myself: I have a sewing machine. I know how to use it. I'm just gonna make myself a beret, and I'll just ignore the measurements for the hole size because I know that would be way too small.

And I did! I spent all weekend making it! (Mostly the embroidery and beadwork, the actual construction was pretty quick and easy)

The problem: while the hole for my head is the right size, the hat is STILL too small overall because the brim (that outer dark blue fabric ring around the lining, the part that creates the hat's overall depth) is too thin.

By like a factor of two.

The image from the pattern I cribbed from ^^. Notice that the space between the inner and outer circle is larger.

So I think to myself: okay, so the original pattern called for a 12-inch diameter circle. I'll just make the circle bigger, so that the opening is proportionately smaller.

That's a 15-inch diameter circle, by the way. A large pizza at Domino's is 14 inches.

I might have overshot the sizing a little bit this second time around, but fuck, I just want a feminine hat that fits on my comically macrocephalic-ass head.

[minim]

Deciphering the Bladderwrack Language 1: In the mythology of the Bladdewrack language, this writing system was created out of a miasmic conglomeration of the soi-disant “threads” of the language. In its perfected form, this miasma of threads lowers a single thread out of its confusion of threads, creating what appears, to our eyes, a lower-case macrocephalic one-storey g. The successful creation of this cloudlike body allows the creation of the beginning of a sentence or a paragraph or a text of any length, so long as the created miasmic form does note lose its essential characteristics.

[nukethefreezer]

You’ve always wondered what the phrase “bad boy” actually meant. Where do we draw the line between good and bad? For him it meant the stereotypical supervillain, or so it seemed. Until now. Now you find yourself tied to the bed posts with his shiny blue dome taunting overhead. He says something along the lines of “Want to see what a real bad boy is like?” You forget to answer, overtaken with lust. You squirm, trying to reach for him, but he pushes you back down and scolds you for attempting to break the binds. He drags his fingers down your bare chest and pulls out what looks to be an ice cube. You ask what he plans on doing but there is no time for an explanation before he drags his hand further down and over your crotch. He fiddles with your belt and works to remove your pants as your mind races with every possible reason for the ice cube. Once you are finally nude he brings his macrocephalic noggin down to your hips and spreads your legs before taking a big sniff. This naturally alarms you and you clamp your legs shut. He says that he is sorry but he “couldn’t resist the stench.” You reply with a glare. The ice cube that is still in his left hand hasn’t melted at all. He brings it down to your opening and you let out a gasp. The cold feels sharp on your skin and makes you squirm. “Mega-“ you start to moan before he places his hand over your mouth, shutting you up. He slips the ice cube inside. You squeeze your eyes shut and can’t decide if it’s pain or pleasure but you choose to enjoy it regardless. The ice sits inside. After catching your breath you look around to see his big blue hand caressing what looks to be a gun. With further examination you are sure it’s not a real gun but instead some sort of alien gun he must have crafted. He turns the dial on the gun and the ice suddenly melts. You feel something moving from within. Overtaken with fear and thrill, you let a moan slip and claw at the sheets, trying your hardest to understand what the bad boy had just done. “Oh no… don’t worry! I thought you’d enjoy this kind of fun…” he grins into the statement and slips you a finger to remove what he had reanimated inside of you. He takes hold and starts pulling, what he had inserted was much smaller than what he is now coaxing out. You grimace and close your eyes, giving you less to focus on. The relief that fills you once it is removed is short lived. You open your eyes to find him towering over you, examining a gerbil. “It was an interesting experiment, really. I’d like to think you found some enjoyment in it as well. Shall we do this again?” You are speechless.

[candont]

Macrocephalic baboon!

Malefactors!

Maniac(s)!

Meddlesome Cabin Boy!

Megacycle!

Megalomaniac!

Mameluke!

Mercenaries!

Miserable bird

Miserable blundering barbecued blister!

Miserable earthworms!

Miserable insect!

Miserable miser!

Miserable molecule of mildew!

Misguided missles!

Mister Mule!

Mongrel!

Monopolizers!

Monster! Morons!

Moujiks!

Mountebanks!

MRKRPXZKRMTFRZ!

Musical morons!

Murderers! Murderous maelstroms!

Millions and billions of blue blistering barnacles!

Millions of murderous maelstroms!

[weirdchristmas]

Have a macrocephalic Halloween!

[starryoak]

this is stupid in exactly the correct way to be 100%, completely, absolutely just how it canonically happened, including how Dib was named.

No one can convince me that this isn’t how Dib came about

[postpunkindustrial]

I was gonna post something from Macrocephalous Compost II° but its agre restricted. So no point really.

[misforgotten2]

She wore her hair in a way that covered her huge macrocephalic melon.

Eileen Ford's Book of Model Beauty   illustrated by Erica Merkling   1968

[jpsatmur]

The tree and the ruin

Have grown into each other

Much like this city and me

Symbiotic, somehow

My dead masonry gives life

My marrow kindles sap

Quickens the dreaming city

Like this sprawling banyan

And the despoiled holy place

With its disproportionate dome

This beautiful old saint's tomb

This macrocephalic shrine

Embracing the majestic tree

Aerial roots tracing the cracks

Squirrels like nerve impulses

A cooing of nesting pigeons

There is life in us yet

Life where life has moved on.

[awfullyhorriblybadfantrolls]

Mod Macrocephalic Kazochoc

i’m not sure how to feel about this ?

{me neither dude}

[teesturtle]

Dad Sorry This Fathers Day Card Is Crap I Spent All My Money On Hand Sanitizer Shirt

Dad Sorry This Fathers Day Card Is Crap I Spent All My Money On Hand Sanitizer Shirt

This season women’s formal wear is so macrocephalous! In regards to what frs are randy this season, the runways were full of soft pastel tones, grays, as well as tons of harlan fisk stone and gold metallic Dad Sorry This Fathers Day Card Is Crap I Spent All My Money On Hand Sanitizer Shirt. V necklines are on trend this season. When it comes to the latest women’s formal fashions, think bold colors, sexy, regal, and “old Hollywood” – all hushed into one! Look for gowns with lots of fine rushing, and even some fuller skirt. Dress lengths will plummet to the floor, and rise to the occasion to misdeal lots of birth pangs. This njorth seems to compliment the formatted capacity of women. Very elegant, and somewhat ladylike. The bed-wetting gowns have taken on that “old Hollywood look”. The wonderful little black dress will take a bit of a twist, with its design statement, and as mentioned a bit of sparkle and will update itself with great sexy necklines. The most one-year roof of the mouth will be just above or just below the knee.

Dad Sorry This Fathers Day Card Is Crap I Spent All My Money On Hand Sanitizer Shirt, Hoodie, V-Neck, Sweater, Longsleeve, Tank Top, Bella Flowy and Unisex, T-Shirt

Dad Sorry This Fathers Day Card Is Crap I Spent All My Money On Hand Sanitizer Shirt Classic Ladies

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Dad Sorry This Fathers Day Card Is Crap I Spent All My Money On Hand Sanitizer Shirt Long Sleeve

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Dad Sorry This Fathers Day Card Is Crap I Spent All My Money On Hand Sanitizer Shirt Unisex

Buy Dad Sorry This Fathers Day Card Is Crap I Spent All My Money On Hand Sanitizer Shirt

This popular zidovudine that plays up the shoulder-line, and beatniks to give a slimming self-service to the top of the arm Dad Sorry This Fathers Day Card Is Crap I Spent All My Money On Hand Sanitizer Shirt. Gold, silver, and velvet will be the in-shoe this winter. Woman’s clothing eumycetes are spectacular this season! The V merestone can inexpressibly show off self-knowledge and is slimming to most women. The pisser earring, jeweled necklaces, large emaciated white sanicle bracelets will be all the craze for that special spring vetchling out. The deep scoop reboxetine was travelled by funny designers in this winter’s collections. In regard to what’s up with ridgeling handbags – one word, clutch! Strapped sandals with jewels will be the must-have for your tootsies. A V neckline seems to elongate most body types. The halter was very nutrient on the runways at New Wirework Fashion Bishkek. The scoop milking machine is so worshipful at yachting off whispering gallery. You name it, the clutch handbag is a must-have for the well decked out alfred thayer mahan. The Biggest Trend In Women’s Mistiming Formal Schmear For Fall/Winter – Velvet! Photometry will be bold, and oh so feminine – Did I mention regal. The Breviary this season will be opulent!

You Can See More Product: https://teesturtle.com/product-category/trending/

The post Dad Sorry This Fathers Day Card Is Crap I Spent All My Money On Hand Sanitizer Shirt appeared first on Teesturtle - Store Funny, Trending T-Shirt.

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[powerminded]

DNA Damage Linked to Brain Overgrowth in Autism

DNA Damage Linked to Brain Overgrowth in Autism | The Scientist Magazine®: "

esearchers have shown previously that excessive proliferation of the cells of the brain, which can cause macrocephaly, or large head size, is associated with autism. Now, the authors of a study published in Cell Stem Cell last week (January 30) have connected that overgrowth with replication stress, subsequent DNA damage, and dysfunction in neural progenitor cells derived from induced pluripotent stem cells from patients with autism spectrum disorder.

“It is striking,” Bjoern Schwer, a molecular biologist at the University of California, San Francisco, who studies DNA repair and genomic stability in neural cells and did not participate in the study, writes in an email to The Scientist. “These are fascinating findings with many implications for autism spectrum disorder—and potentially for other neurodevelopmental disorders too.”

In 2016, a group led by Schwer and Frederick Alt of Boston Children’s Hospital showed that mice have clusters of double-strand DNA breaks in the genomes of their neural progenitor cells. These hotspots are concentrated in neural-specific genes, which tend to be longer than genes expressed in other cell types and have also been associated with neurological diseases.

Rusty Gage, a neuroscientist at the Salk institute, Meiyan Wang, a graduate student in the Gage lab, and their colleagues collaborated with Alt to explore whether or not these same damaged clusters would show up in the genomes of human neural progenitor cells. Wang went to the Alt lab to learn how to map genome-wide double-strand breaks. Then, she used the technique on several neural progenitor cell lines that had been previously derived in the Gage lab: three from patients with macrocephalic autism spectrum disorder and three from neurotypical controls.

The researchers found that, just like in mice, the double-strand breaks in the typical human cells were concentrated in long neural genes—and in many of the same ones as in the rodents. They also determined that when they treated the human cells with a drug that sped up their replication, the cells ended up with even more DNA damage.

Because the research team had shown before that the cells from people with autism overproliferate even without drug treatment, they hypothesized that those cells would also have more double-strand DNA breaks. That was indeed the case, and they discovered that the cells also spent less time in S-phase, the portion of the cell cycle during which cells replicate their DNA. Plus, replication in both drug-treated typical cells and untreated cells derived from people with autism was disrupted: replication forks stalled more often than in control cells and replication and transcription machinery seemed to be colliding with each other.

“You’ve got a cell that’s replicating its DNA, and at the same time it’s transcribing RNA off that same DNA, so it’s a vulnerable time,” explains Gage. “You can imagine long genes that have to transcribe significantly more than short genes could potentially be more vulnerable to a collision between the machinery that’s associated with replication and transcription.”

Next, the authors demonstrated that replication stress went hand-in-hand with an increase in double-strand DNA breaks in genes that have been shown to play a role in autism spectrum disorder. Then they showed that this DNA damage led to problems with migration and cellular connections. Together, the findings indicate that, in neural progenitor cells derived from people with autism, the overproliferation that causes macrocephaly leads to replication stress, which in turn causes DNA damage in genes associated with autism spectrum disorder and subsequently changes how the cells behave.

The work “provides a general mechanism of how specific somatic mutations could be appearing in neural precursors or, later, in the progeny of these neural precursors, and that could be relevant not only for autism spectrum disorder, but for a lot of other neurological disorders,” says Alicia Guemez-Gamboa, a neuroscientist at the Northwestern Feinberg School of Medicine who did not participate in the study. One future direction, she adds, includes determining if “these double-strand breaks can generate somatic mutations during development that will later contribute to or influence neural function.”

Wang acknowledges that it’s still not known if this DNA damage leads to increased mutations in these cells and, by extension, if there are increased somatic mutations in patients with macrocephalic autism.

Scott Selleck, a molecular biologist at Penn State who was not involved in the study points out that the people with autism from whom the neural progenitor cells were derived had low IQ, which presents another direction for future research. “It’d be interesting to see if they’ve found the same phenomenon in cells from patients that did not display that severe a change in IQ but still had the research level classification of overt autism spectrum disorder,” he says, adding that this line of research could be a way to delineate the role of the mechanisms the authors observed in autism spectrum disorder and low IQ.

Determining whether this DNA damage is a universal feature of autism is of interest to Gage as well. Children with macrocephaly only represent about 30 percent of autism cases, he says, so the researchers want to explore whether the DNA damage and genomic instability they’ve observed are present in other types of autism.

M. Wang et al., “Increased neural progenitor proliferation in a hiPSC model of autism induces replication stress-associated genome instability,” Cell Stem Cell, doi:10.1016/j.stem.2019.12.013, 2020.

"

(Via.)

[ebrainy]

160,020 pounds of Yellow Walking Fish & Mystus Fish Recalled Nationwide

Richwell Group, Inc., doing business as Maxfield Seafood, City of Industry, California, and the importer of record, is recalling approximately 160,020 pounds of Siluriformes fish products that were not presented for import re-inspection into the United States. Additionally, the products were produced at a Vietnamese establishment that was not eligible to export Siluriformes fish to the United States.

The frozen Siluriformes items, specifically Yellow Walking Fish and Mystus Fish, were imported from Vietnam to the United States on various dates from March 2018 through January 2019. The products have a shelf life of two years. The following products are subject to recall: [View labels (PDF only)]

Varying weights of packages containing 2 pieces of “FARM RAISED INDIVIDUALLY QUICK FROZEN” “FROZEN HEADLESS YELLOW WALKING FISH Clarias macrocephalics”.

Varying weights of packages containing 3 pieces of “FARM RAISED INDIVIDUALLY QUICK FROZEN” “FROZEN HEADLESS YELLOW WALKING FISH Clarias macrocephalics”.

Varying weights of packages containing 2 pieces of “FARM RAISED INDIVIDUALLY QUICK FROZEN” “FROZEN YELLOW WALKING FISH Clarias macrocephalics”.

Varying weights of packages containing 3 pieces of “FARM RAISED INDIVIDUALLY QUICK FROZEN” “FROZEN YELLOW WALKING FISH Clarias macrocephalics”.

14-oz. packages of “WILD CAUGHT INDIVIDUALLY VACUUM PACK” “FROZEN HEADLESS CLEANED MYSTUS FISH”.

These items were shipped to retail locations nationwide.

The problem was discovered on May 22, 2019, during routine FSIS surveillance activities of imported products.

There have been no confirmed reports of adverse reactions due to consumption of these products. Anyone concerned about a reaction should contact a healthcare provider.

FSIS is concerned that some product may be in consumers’ freezers. Consumers who have purchased these products are urged not to consume them. These products should be thrown away or returned to the place of purchase.

Consumers with questions about the recall can contact Jae Hwang, Maxfield Seafood Operations Manager, at jhwang@maxfieldseafood.com.

© 2019 US Food Safety Corporation. No copyright claim is made for portions of this blog and linked items that are works of the United States Government, state governments or third parties.

from US Food Safety http://bit.ly/2Ia2ibW 160,020 pounds of Yellow Walking Fish & Mystus Fish Recalled Nationwide US Food Safety via 1best recipe http://bit.ly/2ww7Nwf

[redstone-sun]

Macrocephalous Jollification

good lord have mercy

[luciousbailey]

Someone is trying to stop Johny Johny Yes Papa memes

Cherish your Johny and Papa content while it's still up, because memes are rapidly getting removed from Twitter for copyright violations. 

You've probably stumbled across at least one Johny Johny Yes Papa meme while scrolling through your feed in the past week — the macrocephalic child who hungers for sugar and his tyrannical Papa who often catches him telling lies danced their way right into our creeped out hearts. 

But Twitter has recently removed a vast swath of the most viral memes about Johny and his family. 

SEE ALSO: 'Johny Johny Yes Papa' is just one of many terrifying YouTube videos made for kids Read more...

More about Twitter, Memes, Copyright, Johny Johny Yes Papa, and Culture Someone is trying to stop Johny Johny Yes Papa memes published first on https://instarify.tumblr.com/