#reactive oxygen species

[existennialmemes]

[oxygen atom voice] I'm essential to survival! I keep your cells healthy! But if you're not careful, I will also rip those cells apart looking for stealable electrons. Tee Hee! Best of luck, bitch.

[bpod-bpod]

ROS vs Bacteria

Inducing lung lining cells to produce bacteria-killing reactive oxygen species (highly reactive chemicals that can cause oxidative damage) protects against pneumonia without reliance on antibiotics

Read the published research paper here

Image from work by Yongxing Wang and colleagues

Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in PLOS Pathogens, September 2023

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[biology-geology-beaches-india]

Beach birds winging their way over the lustrous liquid silver of the Gosthani River.

The glare here is so intense and must be borne by these birds for such sustained stretches, essentially the entire day, that one marvels these birds do not develop an avian version of snow blindness!!.

We need sunlight to see but sunlight is also detrimental to sight!!!. The ultraviolet rays present in it can cause an opacity of the eye lens - cataract - a serious matter considering that this causes blindness in about 25 million people worldwide. And if there is one species that truly needs ultra-sharp vision for its livelihood it is the high-flying bird!!! Birds don’t peer!!!.

The UV glare from the mobile mirror-like surface of these water apparently cause photo-oxidation of the crystalline proteins in the eye lens, not to mention the generation of superoxide and other reactive oxygen species that do further damage.That the eye lens contains one of the highest concentrations of the antioxidant Ascorbic Acid does not now surprise us!!!

The eye lens is especially vulnerable not only because its proteins are held at super-saturation, making them very vulnerable to precipitation by any chemical or mechanical injury, but in addition do not undergo any molecular or cellular turnover. The lens proteins you are born with are all that you will have for life, and upon reflection it is little short of a molecular miracle that they stay clear and crystalline as long as they do - seven decades.

Cataracts due to relentless sun exposure and glare while out at sea in low-lying boats  - that shortens the distance between the shiny surface and the eye - beset the 50,000 fisherman of Srikakulam district  - about 130 kilometers from here - many of whom develop lens opacities in their forties precluding many of them then from making a living, a serious matter in a people who essentially live from hand-to-mouth..

How these birds - doubtless long-lived, and fishermen in their own right!! - manage to keep their eyes and vision intact over a lifetime - assuming they do, they well might not - is a puzzle that needs explication.

The puzzle is further accentuated by the fact that reflected light is mostly polarized light, and as the pharmaceutical industry has known for a long time, polarized light is far more potent in producing molecular damage than un-polarized light.

May 10, 2010, Gosthani River confluence, Bheemili, Visakhapatnam, Andhra Pradesh.

[medicomunicare]

DNA repair going APE and strand breaks fixing with ATM: please no cash, just redox and contact bases

New research from a team of genome scientists and DNA damage response (DDR) experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments. The new investigaton shows how ATM-mediated signaling is induced by DNA single-strand breaks (SSBs) for DNA damage repair – illuminating the distinct mechanisms of SSB-induced ATM kinase and…

[whats-in-a-sentence]

ROS detoxification enzymes and antioxidants function in cells as a network supported by various antioxidant recycling systems that replenish the level of reduced antioxidants (Figure 24.20).

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[tenth-sentence]

Target proteins include transcription factors, various protein kinases, Ca²+-ATPases, enzymes producing reactive oxygen species (ROS), and ion channels.

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[stevenspacil]

Role of Nrf2 in Oxidative Stress and Toxicity

The role of Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) in oxidative stress and toxicity is critical to understanding how cells respond to environmental insults, including toxins and pollutants. Nrf2 is a transcription factor that regulates the expression of genes involved in cellular defense against oxidative stress. Oxidative stress is a condition that occurs when there is an imbalance…

[icpa]

The role of antioxidants in periodontal health | ICPA Health Products Ltd.

Periodontal disease is a persistent inflammatory condition that impacts the tissues encircling our teeth. This condition arises from an imbalance between oral biofilms and the body’s immune response, potentially leading to the loss of tooth-supporting tissues. When this inflammation is confined to the protective periodontium, it’s termed gingivitis. However, when it extends to the periodontal supporting structures, it’s recognized as periodontitis. This prevalent oral disease, affecting 10%-15% of adults, is primarily driven by bacterial plaque microorganisms. Additionally, factors such as systemic health, oral hygiene, age, gender, and smoking play significant roles in its development.

The double-edged sword of Reactive Oxygen Species (ROS)

Reactive oxygen species (ROS) serve as crucial players in our body’s defense against invading pathogens. These molecules have antimicrobial properties that help combat infections in the oral cavity. However, ROS can be a “double-edged sword” since an excessive presence of these molecules can become cytotoxic to our own cells. ROS plays pivotal roles in cell signaling, gene regulation, and antimicrobial defense. An overabundance of ROS, coupled with inadequate antioxidant capacity, can result in oxidative stress within the affected periodontal tissues. This, in turn, leads to pathological changes and the destruction of host tissues, ultimately culminating in the loss of teeth as their supporting structures degrade. Inside cells, ROS can inflict damage on biomolecules and cell membranes, further exacerbating the situation.

The link between oxidative stress and periodontal disease

Emerging research has elucidated the connection between oxidative stress and periodontal disease. In the early stages of periodontal disease, especially in the case of periodontitis, a prominent oxidative process unfolds, characterized by elevated levels of reactive oxygen and nitrogen species (ROS and RNS). This oxidative onslaught can upset the balance of the body’s response, triggering changes in biomolecules, especially lipids, proteins, and nucleic acids, ultimately leading to damage to periodontal tissues.

The role of antioxidants

To counteract the deleterious effects of excessive free radicals generated during oxidative stress, our bodies possess an antioxidant defense system. Antioxidants can inhibit and reduce the damage caused by these harmful molecules. These natural antioxidants are found in various sources, including foods, teas, vitamins, minerals, and more. They are also used in auxiliary treatments for conditions such as cardiovascular diseases, pulmonary diseases, aging, and atherosclerosis, all of which share physiological links with periodontal diseases. This suggests that the application of antioxidants might also yield benefits in managing periodontal health.

Promising results

Recent scientific inquiry supports the idea that antioxidants can play a pivotal role in the treatment of periodontitis. A meta-analysis comprising fifteen clinical trials demonstrated uniformly positive outcomes associated with antioxidant supplementation during periodontitis treatment. These findings offer hope and promise for those seeking alternative therapies to complement traditional periodontal treatments.

Conclusion

As we delve deeper into the intricacies of periodontal disease, the role of oxidative stress and antioxidants emerges as a significant area of interest. Oxidative stress appears to be a key contributor to the development and progression of periodontal

diseases. Antioxidants, with their ability to neutralize harmful free radicals, hold promise as adjunct therapies in managing and mitigating the effects of periodontal disease. With ongoing research in this field, we are one step closer to a more comprehensive understanding of periodontal health and the potential for novel treatments that can preserve our smiles for years to come.

[jpitha]

The Oxygen Breathers

I thought I posted this one here, but it looks like I didn’t, so here you go!

It was always an event when the Humans visited.

They'd arrive in their sleek, smooth, thick ships; completely at odds with the other ships of the Coalition. Human ships always looked like they were grown rather than built. People would whisper how the Humans made their ships as tough as they were. How human ships could go atmospheric and land on the ground.

It was nonsense of course, no ship - human or otherwise - could do that. Kre'kk figured that the Humans probably spread that rumor themselves.

After they'd arrive, they would come out of the docking umbilical in their small, highly polished suits. They were a rare class of sapient indeed.

The Oxygen Breathers.

Most 'civilized' people in the Coalition came from worlds with manganese sulfur atmospheres. The humans with their oxidizer for a breathing gas were seen as brash, reckless folks who make decisions without proper consideration. Given the reactive nature of their atmosphere, it's practically a given that they too are more reactive in their choices.

Kre'kk stands at attention at the end of the umbilical ready to welcome the humans for their - hopefully - short visit. They come from a high gravity world with a single massive moon - fully a quarter of the size of their own planet itself - so their environmental defaults are... somewhat extreme compared to the rest of the Coalition. The never fail to mention the moon.

As they approached, they reach one half unit away from Kre'kk and stop. He looked down at them - they were about half his height - and he made the Universal Gesture of welcome. The humans reciprocate and Kre'kk’s head frill rustles.

"Welcome to Coalition Orbital 43559 - known to the Lemilar as 'Habilamen.' I am Administrator Kre'kk and I welcome you as equals for you visit."

The human at the head of the group is wearing a slightly different suit. Still polished and reflective, but where the rest of the humans are wearing suits of pitch black - darker than interstellar space - this one is a deep vermillion red. Kre'kk is drawn to the color. It's so rich! It almost looks wet.

When they begin to speak, a simplified icon of a human face is projected onto the smooth polished surface of the helmet. It seems that the humans have taken some care to make themselves look less frightening in their environmental suits. "Thank you for the greeting, Administrator Kre'kk. I am Captain Margaret Kellerman and this is my crew." She gestures behind her. "We plan on staying only for three cycles demi in order to take on a load of Ribanium and trade with any interested parties. I will share with you a manifest of what we have available to trade." She gestures on her arm, and the file appears on Kre'kk's pad.

Kre'kk is taken aback at her voice. It's so clear. She seems to be speaking through a translator, but it is getting the nuance and overtones of the Lemilar Trade Language perfectly. She could have a career as an entertainer or storyteller easily if she was a difference species. Kre’kk swallows. "Uh, thank you Captain, I have received your file and will distribute it. Please make use of our facilities during your stay."

Captain Kellerman's helmet flashed a icon of a face, smiling - without their teeth - broadly. "Thank you Administrator Kre'kk, we shall."

For two cycles, Kre'kk held out hope that the human's visit would be without incident. They came in quietly, did some minor trading, loaded their Ribanium and spent a… reasonable amount of money on entertainment and refreshments - suitable for their systems - while on board. Kre'kk felt they were trying very hard to be model visitors. Apparently they knew humans had a reputation in the Coalition for being... rowdy.

On the last demi cycle before the Humans were scheduled to depart a group of Felimen came over, angry. They had spent the entire two cycles previous loudly complaining that the humans shouldn't be here, and that they had captured Felimen colonies long ago and had begun the process of 'poisoning them' to be more suitable to them. The Human authorities maintain - and have the receipts to prove - that they purchased the planets legally from the Felimen, and never attempted to hide their goals of colonization and geoengineering. Regardless, a long, bloody war had followed and the humans had pushed the Felimen to capitulate and were currently engaged in a Cold War with each other.

Kre'kk was alerted as soon as the shouts started. The Felimen seemed to come to the humans wanting to cause trouble. For their part, the humans tried their best to talk the Felimen down. Their helmet icons were looking sad and quiet and they gestured in ways to try and reduce tension. The Felimen were having none of it though.

As Kre'kk undulated over to try and calm them, one of the Felimen in the back had wheeled out a battle rifle. Kre'kk had no idea how they had snuck it in, but it was completely banned on the Orbital and was cause for immediate expulsion. Before he could sound the alarm and get the Orbital authorities to come, they fired at the group of humans.

It proved to be a fatal error in judgement.

One of the humans in the front of the group was struck directly in their center of mass. They staggered back, and their suit showed significant damage. Luckily for them the suit was not penitrated. The humans reputation for building strong was well earned apparently.

Faster than Kre'kk could follow and only confirmed by viewing the security footage after the fact, three of the humans brought massive slug throwers to bear. Kre’kk knew that the Coalition sapient races find chemical powered metal slug throwers to be far too heavy to be hand weapons. If they are used, they're tripod or vehicle mounted. The humans are apparently experts in their manufacture and use, and can swing them around like they weigh nothing.

The noise of the slug throwers in the hall was deafening. Kre'kk winced as his active noise cancellation dampened the noise and wondered how the humans could take the noise without being injured, but he assumed they must also have some kind of noise cancelling built into their environmental suits.

They fired for a short time indeed, but it was more than enough. All of the Felimen were dead, with the ones in the front unrecognizable. The silence in the hall after they finished firing weighed heavy. It felt like an eternity after they had stopped before the station alarms sounded.

Kre'kk moved over to the humans. They were checking eachothers suits and cleaning up the small yellow colored pieces of metal that come flying out of their throwers when they fire. "Brass" is what they call it. Kre'kk gestured an apology. "I'm sorry. Battle weapons are banned here. You're going to have to leave now."

Captain Kellerman's icon showed pure fury. Her gauntlet covered hand pointed at him accusingly. "You're going to take their side, Administrator? You were here, you saw them. They shot first! They damaged the suit of one of my crew! It was through the luck of Forturne herself that his suit was not pierced!”

Kre'kk slid back one half unit unconsciously. "Be that as it may, you responded with… disproportionate force to their attack. It was uncalled for."

Captain Kellerman sputtered, her melodic voice taking on frightening undertones as the translator worked overtime to relay her fury to Kre'kk. "Uncalled for!? Administrator Kre'kk with all due respect you are out of line. You know about the war I assume, but do you know what they did to our colonies? They dropped nanobombs on our legally purchased colonies. They weren't trying to take back land, they were trying to obliterate us. I was there, I saw it with my own eyes."

Kre'kk was taken aback. This was not part of the standard narrative about the war. "I did not know that no, the Felimen-"

"The Felimen tell their own version of the war in order to garner support and sympathy against 'the aggressor human' I'm sure." Captain Kellerman sounded bitter in the translated voice. "Kre'kk. Your people border the Felimen opposite us do you not?"

"Yes, our territory borders theirs but-"

"And have you by any chance heard of some border worlds coming under some kind of unknown trouble? Maybe a strange illness, or unusually strong weather on the worlds?"

Kre'kk's frill rippled worriedly and he said nothing. He had heard about things like that.

Captain Kellerman cleared her helmet. Suddenly, Kre'kk saw her clearly. Small, with bilateral symmetry, close set binocular eyes and a small mouth, this was the first time Kre'kk saw a human as they are, not as their icons show them. They are predators. They are hunters.

They are terrifying.

Kre'kk unconsciously made a gesture of fear and slid back another half unit. Captain Kellerman's face contorted into a snarl. "Know this Kre'kk. It's only a matter of time before they do to you what they attempted - and failed - to do to us. Think hard about who your friends are and who in the Coalition you can come to for help when they start dropping nanobombs on your worlds." Just as suddenly as it had cleared, her helmet darkened again, and the cartoon icon of her face returned. It felt like a mockery to Kre'kk now.

The humans picked up the rest of their debris and freed their weapons. Faster than Kre'kk could ripple, they were all carrying slug throwers. "We're leaving, Administrator Kre'kk. If any Felimen even come within 5 units of us-" The people behind her cycled a round into their rifles for emphasis "-we will take it as a provocation and will respond with 'disproportionate' force."

"Y-yes Captain. I will relay this information."

"Oh and Administrator Kre'kk? Your Station will be added to the list of Orbitals where humans will not go. We will do no trading, sell no wares, and offer no defense. You and yours will do well to consider your stance vis-a-vis us and the Felimen."

Without another word, the group of humans turned and marched towards their ship. Shaking, Kre'kk signaled that they were not to be interrupted and made sure their warning about Felimen was relayed.

After they left and the mess was cleaned up, Kre'kk sat in his quarters and stared out the window at the planet below a long time. One of his creche mates was living on a newly founded colony bordering Felimen space. He began composing a message to beam to her asking if she had any plans about moving back.

[b1asho]

Round one of the species introduction!!!!

Prectikar Master Post:

Here's some info on them, and if you want to see some other drawings I've done of them (albeit some occasionally older n crustier ones), check out my deviantart: https://www.deviantart.com/blasho

Anyway:

Prectikar are a large sentient species, usually standing at around 8-9 feet tall when fully upright and weighing anywhere close to or upwards if 1000 pounds

They are covered in feather-like fur (or is it fur-like feathers? They're occasionally branched like feathers, and all have quills, but some are more hairlike) due to the cold climate they evolved in, though length and thickness of it now varies by region.

They are omnivorous, and while they have many traits to help them hunt and kill, most of their diet tends to be plants.

Originally rush-down predators, they use their considerable strength to move in quick bursts and their specialized tusks to either ram prey to death or gouge into it as they grapple it.

Their jaw strength is also insane,with their skull actually sacrificing brain space in favor of it, which helps them eat pretty much anything they come across. They pay a lot of attention to food and cooking because of their high calorie needs and very sensitive nose/tongue.

They have manganese as an oxygen carrier is a result of the scarcity of other metals in their environment and potentially because of its general affinity for oxygen.

This causes their blood to be an amber/orange brown and shades of pink depending on its exposure to oxygen.

Through a network of cooperative bonding and other adaptations (like better oxygen retention in muscles and the easily carried size and longevity of the molecule) they’ve managed to bring this manganese transport molecule close to hemoglobin in terms of effectiveness, though they can also make use of manganese’s catalyst properties to temporarily push it to bring lots more oxygen to their tissues at a time (used for short bursts of speed and strength that allow them to take down large prey and plants for food).

their large body size (selected by their colder environment) lets them use their own high body heat to keep the O2 fixation and liberation going in their highly effective lungs.

An extensive understanding of their internal chemistry is unknown (aka gatekept by their colonizers/"uplifters" who ill get to later) but it seems like they also have a network of bacteria in their body just to manage the more reactive and damaging oxides that form, and to remove/convert the spent manganese into connective tissue and aid in bone maintenance.

They have higher calorie needs from keeping up the body temp and recycling/removing all that stuff, alongside just being big in general. Alongside a lot of sleeping, they also basically just eat all the time (compared to other species) to compensate, though their mammal-like fat retention and other metabolic adaptations for scarcity mean that they can handle long periods without resources(though this causes increasingly compounded problems for them)

Some other downsides include low tolerance of changes in oxygen levels (particularly low) and temperature levels, and poor adaptation to environments outside of their biosphere/without all the microorganisms since these things upset their delicate balance.

(part of why so many tribes were nomadic was/is to chase temperate and ‘warm’ seasons, even though to us that’s still cold. Prectikar living in human dominated areas often just take a lot of supplements with beneficial bacteria in them to cope with thr lack of that in their environent, and any food printers need an 'ink' cartridge containing these things or else theyre basically useless.),

They also experience faster general wear and tear from having constant complex and intensive chemical reactions(sometimes with dangerous chemicals) going on in their bloodstream and tissues.

( I’m not a biochemist, so if there’s any glaring issues with this then just explain it away to yourself with ‘they have a gland for that’ or ‘just don’t think about it actually’ which is what I did. I just wanted the fun color with a metal that can reversibly bond with oxygen :). )

They have one nasal passageway for smell/air and a second, bigger cavity for just vocalization (which they can’t breathe in from as easily).

This second cavity is between their first set of eyes, and has a phonic lip structure inside to produce higher pitched sounds.

The upper nasal opening has muscled nostrils that act as lips to further help control sound. The noise coming from here sounds very high to them, but to us it sounds like a nasally human voice, broken uobhere and there with squeaks, buzzes, and clicks).

They can pitch this nose voice very high, closer to dolphin-like clicking noises but not quite echolocation level.

Their throat vocal cords by their air sac are very long and thick, used for making very deep noises that carry long distances.

However, the vocal control they have through their mouth is very poor due to this and the inarticulate lips and tongue they have, and due to the more limited air they can bring in and out of it, so when speaking only through their mouth they sound a lot like seals or dogs and can only really go in short bursts before having to refill the sac.

Most of their languages are spoken with the nose and mouth sounds in tandem, where the high and low mix to make a more even sounding voice.

It’s fairly easy to understand them, but nearly impossible for us to truly speak any of their native languages, and if they wanted to they could also just start making sounds we cant hear.

They see it as strange that humans and other species speak with a single tone without difficulty.

The red flaps pictured on the drawing of their mouth and nasal passages can be moved to seal off the passage and direct airflow elsewhere.

The big red one in their throat acts as a “diaphragm” to fill and empty the air sac (which is left over from when their digestive and respiratory tracts were more connected like ours, but time in the water heavily shifted it to a more ‘blowhole’ type outline to help them breathe and vocalize from the surface).

The other flap by the air sac and its vocal cords moves upwards to block off the digestive tract whenever the mouth or nose is opened to allow air to be drawn in by this diaphragm.

The two red flaps making a pinched shape can move independently or with the other red flap, but never at the same time with each other. The main airway is always separate from the digestive tract, though the flap to the middle, non vocal nasal passage can be moved so that it’s a part of either the vocal nasal passage to draw in air or the air sac part to act as another resonance chamber.

Air can be drawn in by the diaphragm via open mouth and through the nose via open top red flap at the same time, and can be released at the same time, resulting in their near continuous double speak sound they use for their own language.

Their characteristic large tusks are retractable and housed in a cone-shaped bony socket on the side of their jaw.

A muscle is attached to the bony root of the tooth, and pushes it out. As it slides towards the front of the mouth, the cone socket narrows and wedges a protrusion on the tooth into a hole in the socket, and then the muscle stiffens, locking it in there.

When the tusk retracts, the muscle quickly jimmies the tooth forward then draws it back to get it out of the hole, and then pulls it back into the wider part of the socket.

This is mainly because their tusks are ever growing (but very slowly) but not great at self sharpening, and are their main weapon in self defense and hunting,so it seems this just happened to keep them safe.

If a tusk is broken, as long as it was not cracked at the root, it can be regrown with extensive time in the socket, but otherwise they stay safely stowed in da socket where the majority of its sharp edge can stay protected from chewing and other mouth stuff. Tusks won't start growing in until their teenage years.

They are primarily bipedal/ quadrupedal and switch between the two occasionally.

Knuckle walking helps distribute their top-heavy weight and give them more balance for long and short distance, while walking upright gives them better visibility, less stress on their neck/upper back, and quicker but unsteadier movement.

Their gallop/sprint utilizes both arms and legs to propel them forward in a gait halfway between a bear and a gorilla (since their big mid arms are set like a bears) to overtake prey after an ambush or drive them into the rest of the pack waiting elsewhere. Quad walking also helps them get around in buildings meant for species half their size.

Their hands are some of their only places without hair, but as they age, they loose it on their arms and face too.

Prectikar have different uses for each of their pairs of limbs, and have for all stages of their evolution.

The front ones specialized for grappling prey and grabbing things, and so have a ‘sprawling’ shoulder position like humans and have hands with relatively nimble fingers, the outer two are angled inwards but can also move in a pamprodactyl ish fashion (which acts as their version of a thumb, and lets them switch from big to little grabbing motions) .

Their mid limbs used to be wings with hands, and still have a basically zygodactyl finger position that was helpful for holding onto branches (with the backwards facing finger), but over time they have been converted into terrestrial knuckle-walking limbs, with the one that swings back and forth being brought forwards to walk or swung back to adjust grip on big things they want to move or for balance on unstable terrain like ice . The fingers on this one are big and clumsy, pretty much only useful for digging, walking, or slashing.

Their back limbs also used to be for grasping but were mainly counterbalances, but have now turned into plantigrade walking limbs (and much like humans, that’s pretty much all they use them for). All have nonretractable claws.

Prectikar are viviparous and usually give birth to litters of up to 8.

They have a specific mating season, where their dimorphic traits will become more pronounced.

Males in rut will shed the feathers on their throat sac region and it will become a bright ambery yellow color, and they will also grow in longer feathers on their butt region (in a fan shape for display purposes. The dont have a true post anal tail like humans).

They will also develop some of that pinkish orange/yellow on their chest skin. Females go throguh estrus cycles and will also grow a more prominent butt feather crest, as well as some very long feathers around their neck, shoulders, and abdomen for babies to hold onto.

Their skin patches turn a much brighter shade of yellow to help direct newborns to where they can feed from. Once they give birth, they will start making an oily and thick secretion across the skin patch which is collected into a divot which the infant licks from. Part of why the babies hold onto them is so they can constantly lick the 'milk'so they can grow.

Newborns come out blind and hairless, but quickly grow in a thick down and open their eyes so they can climb on mom.

Once they're weaned, they'll drop off and use the muscles they gained hanging on and climbing to start moving with the adults. They grow very fast, and canes are a common sight in teens to help deal with the rapid bone and muscle growth.

Usually, it is only during this season where chest/skin related nudity standards change to be more conservative, since showing those colors means youre down to fuck and so doing that is usually restricted to in private with their partner or for bachelors.

They have very strict binaries for sex and gender based on this seasonal divide and religion.

Most tribes show gender identity through a piercing on their lower nose for male or chin for female (so dont worry, the main guy up there is showing some male presenting chest outside of the mating season, so hes fine).

Normally, only some cultures pierce their ears, which are like if owls had a little mobile flap of outer ear to swivel I stead of their whole head. Very little of it is actually flesh, and the sound is mainly captured by the feathers around it.

While they have a reputation otherwise, Prectikar are highly social within their tribal/family groups.

They regularly allogroom, greet each other with hugs, and usually travel in sibling groups. Households are multi generational.

They have a reputation as standoffish or irritable because they take things very differently and have other standards/specific body language truggers. also most other species treat them differently/with fear by default.

their upper pair of eyes is larger and focused on long distance vision while their lower pair is for close up vision, creatign a bifocal effect for them when using both at once.

Aaaaaand that oretty much everything, I think. I'll post some other arts related to them soon, but consider this the Master Post on the things you should know about them!!

[mindblowingscience]

The human papillomavirus (HPV) is responsible for the vast majority of cervical cancer cases, but this isn't a sexually transmitted infection that just one half of the population needs to worry about. Researchers from Argentina have found strains of HPV which put people at high risk of cancer are associated with a greater percentage of dead sperm. In semen samples from those with high-risk strains, scientists noticed a lower count of white blood cells and an elevation of reactive oxygen species, which can damage sperm and alter DNA.

Continue Reading.

[bpod-bpod]

Egg Timer

Our cells are replaced every few weeks as they accumulate damage. But there’s one big exception: egg cells. In a seemingly high-risk strategy, women are born with all the eggs they will ever have, yet an egg may wait decades before creating healthy offspring. So how do they avoid the damage that other cells are subjected to (image shows a human egg cell (crescent shape) surrounded by granulosa cells which nurture the egg cell)? They go into ‘standby mode’. Cell damage is often caused by reactive oxygen species (ROS), which are created in the mitochondria, specifically in a compartment called complex I. In egg cells, this complex is inactive which creates less ROS and reduces the chance of developing damaging mutations. By adding a dye to the eggs, researchers saw that their mitochondria are less active (green) compared to those of the surrounding granulosa cells, which are producing more damaging ROS (red).

Written by Sophie Arthur

Image adapted from work by Aida Rodríguez-Nuevo and colleagues

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature, July 2022

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[brightlotusmoon]

Now this takes me back to a 20 year old hyperfixation on herbs and plants with medicinal benefits. I did not expect to find this in my search.

[unidentifiedmammal]

Alrighty so this is the post on lichen dyes!

this particular bath of lichen dyes was originally started over a year ago scraping a tentatively-ID'd lecanora and/or ochrolechia genus lichen off of a fallen branch (remember, don't gather lichen when it's still growing! it's very slow growing and easy to overharvest)

to start off, this particular type of dye is made through the ammonia-fermentation method, also known as ammonia maceration. No actual bacterial fermentation occurs though. Rather, the compound orcinol (and precursor compound to orcinols) react with ammonia (N2) and oxygen to form the compound orcein (also called orchil/archil) which is what makes the final dye!

this process takes anywhere from 3 weeks to 16+ weeks depending on the lichen species, its constituent acids, the temperature, and the frequency of aeration.

This batch was set aside for several months and neglected a good bit, but it still works. I strained out the crumbled lichens (which i set aside for later) and diluted it 1:4 as instructed by a very good book called Lichen Dyes: The New Source Book by Karen Diadick Casselman. This book is basically omnipresent everywhere you see lichen dyes mentioned, especially the orcein-based dyes. I also used several websites/videos/papers and such that i've hunted down over various internet crawls.

I use an old coffee pot for this as it's both a non-reactive material (glass) and is built to withstand heat. Ironically i also scraped the lichens off the branch using a tool i made out of a metal band from the broken handle of this same coffee pot!

I decided to dye some eri silk cakes that i fluffed up and scoured. these have been very good at absorbing dye in the past so i would hopefully get a good result from them. As lichens are a substantive dye i don't have to put a mordant on them, but i did soak them in an alum solution just before adding them to the dye bath to hopefully maximize dye uptake as well as improve fastness as lichen dyes are also fugitive and can fade in sunlight.

Substantive dyes contain mordants already embedded in them; fugitive dyes are a bit fuzzy to me but my understanding is they end up trapped in the fiber instead of actually bonding to the fiber in a stronger way. Mordants are used to help the dye "bite" onto the fiber better, improving both fastness (the ability of a due to resist fading from sunlight/washing/time) and the brightness of a color. Alum is useful in that it typically doesn't affect the end color of a dye more than simply making it slightly more strong!

it was pretty successful i'd say! i warmed up the dyebath, added the silk, let it simmer for a few hours, let it cool down overnight, and then warmed it back up the next day for a few hours; then, when it cooled, i took it out, let it dry, then rinsed it, and let it dry a second time. At that point, it was ready for spinning!

It was a lovely pink color that's not fully captured by the camera like most dyes, and eri silk is lovely because you can spin the clouds directly and easily without carding and make lovely relatively threadlike yarn

this was the first skein i got! i love how shiny the silk is. Some dyes can get really purple or even magenta-like!

next, i had the leftover lichens that i had set aside. They were a crumbly texture and dark black and i dried them out, crushed them up more, set them back in a jar, added more ammonia and water, and did the ammonia fermentation method a second time! this was after reading about the method for making french purple, and while this is definitely a very pale imitation of the method, the double-soak is the key feature here

here it is (on the left); it was already way darker purple than an in-progress lichen dye i had yet to crack open and use

speaking of which, heres a shot of various test lichens i had while working on this, you can see the blue-capped jar that has the second-soaked lichens. the foam will often give a preview of whether or not the dye will be red/purple or not!

Here it is, i forget how long i let it soak but i think it was a bit over a week. i strained the material out, diluted it, and then repeated the same warm/cool/warm/cool/dry/rinse/dry method with more eri silk

And below you can see the difference, it's definitely slight but still cool!

the left is from the original dyebath, the right is the second-soaked one. the first one is more salmon-colored while the second is a tad more blue-purpled!

I'm extremely excited about this, these dyes have such a fascinating history and have multiple historical uses everywhere from florentine orchil to norwegian korkje to scottish cudbear and more, and it was often used in tandem with the roman murex/tyrian purple dyes that come from a mussel. Some folks used the lichens to pre-dye the fabric before dyeing with tyrian purple, both to stretch the expensive tyrian purple and to make the end color more vibrant. It's all such a great topic that's mightily confusing and could take up a post of its own, same with the underlying chemistry of what makes these dyes work in the first place!

Anyways that's all for this post, i have more i'm working on involving actually turning these dyes into paint that i'll hopefully turn into a post on its own soon! I've also got other lichen dyes I'm waiting to get through the ammonia fermentation process that will hopefully give other colors, whenever that may be!

[existennialmemes]

Absolutely True™ Science Facts!

The moon cannot generate its own light. instead it reflects light from the sun. It briefly struggled with an inferiority complex, but after therapy it no longer feels compelled to compare itself to others. It knows our power lies not on every individual being exceptional, but on our exceptional capacity to work together.

Carbon is known as the building block of life, as it is present in all organic compounds. Carbon is most stable when it is bonded to four other atoms. Carbon, like many other atoms, has been practicing ethical non monogamy since the beginning of physical matter,

The Sun burns at around 10,000 degrees Fahrenheit. It does this because it said something awkward 4 billion years ago, and it's been stewing over it ever since.

Oxygen is a diatomic molecule, which means an oxygen atom is most stable when bonded to another oxygen atom. On occasion, oxygen molecules have an ugly break up and go on rampages throughout your body. These divorced atoms are known as "Reactive Oxygen Species" and you should be sure to avoid them if you see them pop up on your dating app.

[whats-in-a-sentence]

Rapid SSA responses to different abiotic stress conditions, including heat, cold, salinity, and high light intensity, have been demonstrated to be mediated by a self-propagating wave of ROS production, which travels at a rate of approximately 8.4 cm min^-1 and is dependent on the presence of a specific NADPH oxidase, respiratory burst oxidase homolog D (RBOHD), which is located on the plasma membrane (Figure 24.14).

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.