#shca

[int3rn3tp1x13]

interest updat + loosing interests in stuffs

hello im back from the depths of the ocean, just here to give a small interest update. BECAUSE IM A LOSER/j

started working at SHCA again but as a orderly! its fun so far but a bit stressful

IM STARTING TO LOSE INTEREST IN LAW OF TALOS/ENDZONE IM GONNA CRY- i know its a normal thing, to lose interest in something but its like, interests are huge thing to me.. losing it is kind of like losing a friend. my interests make me happy when life doesnt!

but yeah, it sorta sucks when you get that feeling of like "wow im losing interest in this" it happens with most of my interests so its not anything new. thankfully, theres always something to fill the empty space so i am never alone with my thoughts

rolling back over to law of talos/endzone for a moment, before i kinda leave the fandom for a bit i want to finish the 2 fics i have for it. they just been collecting dust in the corner </3

ANYHOW, interests may go away, but they always come BACK this is to say im obssesed with portal 2 again (my love for it never really went away tbh) ive also been becoming interested in eddsworld again (shivers)

well i think thats about it, see you all later! *scurries back into the dark alleyway laughing evilly*

[mantorjustsports]

Best CricketAcademy in Faridabad

The SledgeHammer Cricket Academy (SHCA) seeks for and develops India’s best cricketing potential. Best Cricket Academy in Faridabad, We operate with the express purpose of developing and preparing people for future difficulties by giving them the best cricket instruction, cutting-edge cricketing facilities, and an excellent opportunity to learn and discover more about the game from trained instructors. 

Our goal is to find young people and provide them with the chance to learn new skills and enhance their leadership qualities, which will ensure their entire development as a cricket player and a person. Our coaches are actively involved in all aspects of the on-field team’s operations. 

Since coaching methods are passed down from one generation of coaches to another, learning the plays and strategy of the game involves a certain set of skills.

SERVICES WE PROVIDE

In all of our running academies, we have 2 to 4 acres of space for practice, including 5 to 10 pitches with lighting.

We provide certified coaches in all age group + ex cricketer visits. 

We have all BCCI affiliated age groups like under 14,16,19,22,25 .

With different timings of batches 3:pm to 7.30 pm .

We also organize international and domestic tours for kids and corporate players to get maximum experience and exposure.

A few of the players in our academy have already competed for their school and state at various age levels.

COACHE PROFILE

DEEPAK SHARMA

Head coach Mantor’s

Mantor's Sports Cricket Academy in Faridabad

Well qualified and well experienced in CRICKET coaching for more than 5 years Academic.

DONE MBA FROM JAMIA MILLIA ISLAMIA Professional

Achievements:-

DONE ICC LEVEL 1 from icc centre (dubai) Achievements

Was part of DELHI DEREDEVILS camp PLAYED 3 consecutive year state from up and delhi Played district ptaudi trophy Played icc ramadan trophy and all major tournaments of DDCA HCA AND UPCA

National Levels :-

Qualified and played SGFI 2 times and 3 year’s national and reached till semi final level Also represented 9 times various universities in ALL INDIA UNIVERSITY CHAMPIONSHIP AND ALSO WAS PART OF VIGGY TROPHY. Was best performer in most of the reputed tournaments represented.

[thewistfulwordwitch]

New #review #ThisIsKindOfAnEpicLoveStory by #KacenCallender This is Kind of an Epic Love Story by Kacen Callender is such a sweet story of young love. The characters are endearing, and so real. You can't help but feel bad for Nate every time he fucks up because you can sympathize with him too. I also want to read his script now! You just want to cheer the rest of them on too - Ollie, Flo, Ashley, and even Gideon. My maternal instincts fired up several times, lol. I really enjoyed the diversity of characters and found myself trying to remember the signs she described, as I used to know some ASL. Like teens IRL, the book is filled with angst, about friendships, romantic relationships, familial relationships, school, wondering what the future will bring. Being scared of the unknown... Hell, being an 'adult' is a lot like this too! And "maybe the ending isn't even really the point. Just as long as there was a happy somewhere along the way"... . . . . . #goodreads #Amazon #kindle #Bookbub #StoryGraph #iheartbooks #readingisfundamental #book #books #readallthebooks #booklover #bookworm #bookwrym #bookstagram #bookstagrammer #booksofinstagram #booksbooksbooks #read #reading #readersofinstagram #readmorebooks #readyourbooks #readabook #readallthebooks #authorsofinstagram #writersofinstagram #booksarelife https://www.instagram.com/p/ClkAaS-shCa/?igshid=NGJjMDIxMWI=

[dabadnewz]

Slaptima Disassembly 2 of 2

Watch me pull the last few pieces of car audio equipment (the “big 3” 0 gauge power and ground wires), remove the plates, and get my totaled Nissan Altima Coupe towed away forever!

[melport]

[haughtsoundz-blog]

Burnt a little of that midnight oil last night, cut out two massive octoports for a quad 15 enclosure. #haughtsoundz #stayloud #octoport #latework #skyhigh #audio #loud #audio #subwoofer #enclosure #speaker #box #install #work #skyhighcaraudio #shca #wire (at Haught Soundz) https://www.instagram.com/p/B0lbTrrgOpg/?igshid=2tbpb32x9vlm

[littlestarcafe]

Final Space for Send Me a Fandom

SEND ME A FANDOM 

The first character I first fell in love with: Gary, such a lovable badass dork The character I never expected to love as much as I do now: Surprisingly, I never expected to love Avocato, I found him cool back then but he is quite an interesting character that I ended up falling for The character everyone else loves that I don’t: Not really The character I love that everyone else hates: HUE and KVN, yes I kinda like KVN now, he might be annoying but he is kinda cool The character I used to love but don’t any longer: Lord Commander, cool bad guy but some fans just rubbed me the wrong way The character I would totally smooch: Gary, Quinn and Avocato, oh and also Fox The character I’d want to be like: I feel like I'm alot like both Gary and Little Cato The character I’d slap: Clarence and Sheryl A pairing that I love: Garycato (obviously), Polyspace, Quinnary, EvrAsh and I have a soft side for QuinnCato; oh there is also Little CatoxGumball (my friend's crackship) that looks fun A pairing that I despise: Any ship that involves Little Cato and an adult characters, specially A/shCa//to, its just too gross

[myatlantamomsclub-blog]

My sweet girl graduates from #prek today. 5 years have flown right by and I'm so thankful I've gotten to see it all. #graduation #capngown #preschool #girlmom #mamc #atlkids #atlmoms #georgiamoms #shca (at Sugar Hill Christian Academy)

[int3rn3tp1x13]

omg.. times goes by.. UPDATESL OLZ

WOOP WOOP SUMMERS HERE BABY!!!

mini school rant(bleh) its been pretty great! i hate school so much, felt like i was going to implode any second!! I still have things to worry abt school wise but honestly, i dont think i care anymore. its summer and im gonna have fun :) RANT OVER

OMG OMG OM- so much fnaf news!!! movie!dlc!vr! eeee im literally so excited for all of it!!! and MERCH!!! i love spending money, i literally preordered the new sun&moon figures on amazon (i hope they come lol) ive already seen ppl getting theirs but i have to wait until next month to get mine :(

also update to my last post: i got fired from shca lol, which is like totally understandable. i was pretty offline for some time but it was fun! might try to be a medic again but who knows.

ALSO NEW OBBESSSINO!!!!!!!!!!!!! SPIDEEVERSE!! which im pretty sure is most ppls obsession rn. the movie was absolute amaazingness!!! BUT MY OBSESSION MOSTLY LIES WITHIN THE SPOT!!!!!!!!!!! hes my dream guy..my little meow meow omg hes literally my type.. >//< - but cringe aside his character is so cool man. understanbly the next movie is gonna take awhile to come out (jeez im probably gonna be 18 by the time it comes out..) im willing to wait ofc but i dunno if my obsession with the spot will last that long, (NO ILL LOVE HIM FOREVER!!!!!!!!(lets see if thats still true 2 months from now</3) i believe in myself, sorta..

ee well art wise i think im getting better? eh ive been a bit unhappy with my art lately, i just dont think its interesting or all that pretty.. so im gonna try my hardest to improve!! though, when doing a redraw of one of my drawings from around 2021, i saw a HUGE improvement. which honestly,, made me feel better about my art. i guess its true that it can be hard to see improvement in urself unless you really compare!!! or something like that but yeah!!! keep practicing!! its advice that always rings true for the most part :)

ALSO YEAH!! another notable obsession, needy streamer overload!!!!!!!!!!!!!! KANGEL 4 LIFE....i almost got all the achievements!!! i just need two :3

i dont i missed anything else?? but yeah, life is pretty nice. its a bit lonely but who cares >o<

bye bye

[dj-rmc868]

Post by @sky_high_car_audio_ BASS HEAD PROBLEMS.... #caraudio #12v #shca #sundownaudio #bassheadsunite #basshead #caraudio (via #InstaRepost @Fluxtechsolutions)

[captain-temhote]

My Fursona/Scalesona redesign partially based on my cultures legends/myth and some favorite animals

By the way, i know people rarely view my blog but i wanna say thank you all for doing so, still. Also i am mostly active in SHCA ((roblox game)) as a medic at current time and 6 hours from now

[dabadnewz]

This is how I mourn…(been looking online for the next project, but having very little luck) https://www.instagram.com/p/BuUnpO_ga9e/?utm_source=ig_tumblr_share&igshid=1y00hgqit9ig9

[ijcmcrjournal]

p66ShcA, A Context Dependent Player in Promoting Cellular Plasticity, Lung Metastasis and an Epigenomic Basis for Breast Cancer Metastasis by Hudson J*

Editorial

Metastasis is responsible for 90% of cancer-related deaths and includes efficient and inefficient steps, with the later stages being rate-limiting to successfully establishing metastases. Src homology and collagen A (ShcA) is an adaptor protein that relays extracellular signals by coupling to receptor and cytoplasmic tyrosine kinases to control cell proliferation, survival, invasion, and angiogenesis [1]. The ShcA allele encodes three proteins that originate through alternative promoter usage (p66) or alternate translation initiation (p46, p52) [2]. However, the role of p66ShcA in recurrence is conflicting and poorly understood in breast cancer [3], and even across cancer types, as p66ShcA has been reported to have pro or anti-metastatic features depending on the context [4]. Reactive oxygen species (ROS) are important in the regulation of cell proliferation, apoptosis and cell survival. The major source of ROS in the cell is from the mitochondria and the formation of ROS can also enhance the metastatic potential of breast cancers by perturbing mitochondrial respiration and enhancing migration and/or invasion [5]. Indeed, there had not been any in vivo studies performed in breast cancer elucidating the role of p66ShcA in this setting and we recently set out to answer these questions [6].

Previously, we provided the first in vivo evidence of the role of p66ShcA in ErbB2+ breast cancer in inducing an EMT to promote cellular plasticity and tumor heterogeneity (Figure 1), left panel [6]. Reversible conversion between epithelial and mesenchymal states has been associated with metastasis, increased tumor heterogeneity and resistance to therapy. In TNBC, we recently demonstrated that distinct pools of p66ShcA are necessary for lung metastasis [6]. Both cytoplasmic-p66ShcA and mitochondrial-p66ShcA are necessary at different stages (Figure 1, middle panel). At the earliest stages, cytoplasmic-p66ShcA increases the migratory capacity of TNBC cells, potentially to increase access to the vasculature. During extravasation, cytoplasmic pool aids in the turnover of focal adhesions, increasing their assembly/disassembly, reducing their size and surface area to potentially aid in lung colonization and reactivation of proliferation pathways. These data raise the intriguing possibility that integrins and/or additional cytoskeletal proteins (such as FAK/RhoA/Rac1 which have previously been shown to interact with p66ShcA/ShcA proteins) are involved in p66ShcA-dependent colonization to aid in adhesion/tension-induced mechanotransduction. Mitochondrial-p66ShcA, however, is necessary for increasing CTCs in the bloodstream from the primary site and this correlates with lung metastasis from the primary site. Notably, cytoplasmic-p66ShcA was unable to rescue lung metastatic burden from the primary site compared to breast tumors lacking p66ShcA, indicating mitochondrial p66ShcA is necessary for intravasation or increased survival once in the bloodstream.

Intriguingly, a foundational role for the epigenomic contribution to metastasis has been established, whereby a lack of CpG island methylator phenotype (B-CIMP) correlates with recurrence and reduced survival in breast cancer [7]. Of note, p66ShcA expression is up regulated in both TNBC and “claudin-low” metastatic variants to the lung and liver and basal breast tumors compared to the luminal subtype [6]. In addition, p66ShcA is regulated transcriptionally in TNBC, raising the possibility that p66ShcA may be regulated epigenetically during breast cancer metastasis (Hudson et al. Under Review) indeed, an increase in active chromatin was seen at the p66ShcA promoter in basal tumors and in aggressive metastatic variants. Furthermore, CTCF a known regulator of chromatin was enriched at the p66ShcA promoter and PARP1 regulates p66ShcA expression in these cells. These data support the potential role for an epigenomic program in breast cancer metastasis that may include p66ShcA, a novel promoter of breast cancer metastasis. Hence, p66ShcA may serve as a biomarker of aggressive breast cancers at increased likelihood of metastasis to the lung and liver.

Notably, methylation of CpGs within the CTCF-binding site prevents binding of CTCF, integrating DNA methylation and insulator function in gene regulation [8]. Recently, CTCF was shown to regulate the forehead transcription factor (FOXM1, a key regulator of the cell cycle, DNA damage response and EMT), and a CTCF-FOXM1 axis regulates tumour growth and metastasis in ovarian cancer [9,10]. FOXM1 is frequently overexpressed in cancer and a gene expression signature of FOXM1 predicts the prognosis of luminal breast cancer patients [11]. FOXM1 was also found to co-bind with estrogen receptor alpha to regulate luminal breast cancer. Finally, FOXM1 was shown to promote stemness and radio resistance in glioblastoma and increased mitochondrial function and tumorigenesis through expression of PRX3 in colon CSCs [12]. Hence, these findings integrate various processes including EMT, mitochondrial function, stemness and epigenetic regulation by CTCF to coordinate an epigenetic program that supports metastatic progression. It will be interesting to determine whether a CTCF/p66ShcA-driven axis exists and contributes to metastasis. Furthermore, future studies should delineate the importance of p66-dependent regulation on metastasis, potentially focusing on acetylation and methylation and their associated epigenetic players such as Sirt1 and DMNT 1 and 3b.

The role of p66ShcA is outlined in an ErbB2+ luminal and basal breast tumor models. Cytoplasmic p66ShcA induces an EMT and promotes cellular plasticity and tumor heterogeneity in a HER+ setting, while cytoplasmic p66ShcA promotes cell migration, colonization of the lung and reactivates cell proliferation pathways at secondary organs (lungs). A schematic of the epigenetic regulation of p66Shca is outlined in TNBC whereby CTCF binds to the p66ShcA promoter at activated chromatin (black marks = active histone marks H3K9Ac and H3K27Ac and beads = Histone 3), potentially through PARP1 or other chromatin modifiers (SIRT1, HATs?) to induce transcriptional expression of p66ShcA in aggressive metastatic breast tumors. Hypomethylated DNA correlates with p66ShcA expression within the p66ShcA promoter and hypomethylated DNA has been proposed as an epigenomic basis of metastasis in breast cancer [7].

For more information about Journal : https://ijclinmedcasereports.com/

https://ijclinmedcasereports.com/pdf/IJCMCR.SC.ID.00032.pdf https://ijclinmedcasereports.com/ijcmcr-sc-id-00032/

[jsalternators]

@emerybowling Awesome Air Cooled VW Memphis Car Audio install with Js 240amp.🏁 Js-Alternators.com Your #1 Source for High Output Alternators. 🇺🇲 Js-Alternators.com/quote Js-Alternators.com/performance 🏁💯 @memphiscaraudiousa #jsalternators #memphiscaraudio #dbdrag #атвозвук #bassheadlife #subwoofers #texas #caraudio #skaraudio #basshead #carstereo #caraudioaddicts #bassheads #rockfordfosgate #ampereaudio #12volt #caraudiosystem #shca #dcaudio #lowbass #caraudioinstallation #bass #sundownaudio #carfabrication #spl https://www.instagram.com/p/CKKM5cQMgHT/?igshid=1dx5eb5cyh2or

[xplicitaudio]

🎶⚡👌A large build consists of many components. Make sure you have everything you need like #SHCA install accessories and #SBC RCA distribution from www.xplicitaudio.com/?ref=793 💎 YOUR #1 source for #caraudio ✔ Lowest Price Guaranteed 💰 No credit needed w/...

[myatlantamomsclub-blog]

What an amazing morning of praise and worship, friendships, picnics and egg hunting. #atlantamoms #georgiamoms #atlmoms #mamc #therealhousewivesofatlanta #sugarhill #shca (at Sugar Hill Christian Academy)