#tlr yi

[lesbianleonardo]

LAST RONIN 2!!!!

[turrondeluxe]

Know peace

[sweeneydino]

Do you think spikes soul went somewhere else? He couldn’t have just disappeared…

👀 😬

Uhhhhhhhhhhhhhh

[theyhavetakenovermylife]

I'm already so in love with these kids. I just got my hands on The Lost Years, and I already adore them. They are so much like their uncles, yet they all have their own personality. So cute! Amazing! Love them!

[art-killed-the-superstar]

day 12: golden rule uno, never sneak up on a turtle while she's welding!!!!!

[sivistheone]

Yi's finished!! I'm so excited!

[roninreverie]

Silly little edit, but what kinds of masks do you think these kids will wear? Based on that silohuette picture out there, they may not wear any at all. If they do, do you think they will all be one color like red or black? The old 4 colors because they found spares in the lair? Totally new colors? Or like a kalediscope colored pencil blend of colors?

[love-killed-the-superstar]

give it up for day 3 of crying over yi ninjaturtle

[genius-in-training]

[Arai's come back a while later. He's sitting in the TLR lair with Inori and Sanka draped over his shoulders and Munei napping across his lap. They're playing Pokemon.]

-@araimahou

*Yi comes for once out of her room, looking a bit confused to them all*

"Hey, what are y'all doing?"

[crimsonpublisherscancerstudy]

Toll-Like Receptor Agonists in Cancer Therapy-Crimson Publishers

Toll-Like Receptor Agonists in Cancer Therapy by Yi Lu in Novel Approaches in Cancer Study

Toll-like receptors (TLRs) are single membrane-spanning proteins that are present on the membranes of immune cells involved in the innate response. Detection of pathogen-associated molecular patterns (PAMPs) initiates the adaptive immune response (antigen presentation). To date, 10 TLR genes have been determined in the human genome, and 13 in mice. TLRs are commonly adapted for use in neoplasia therapy, but different aspects of TLR function may suppress or promote tumor development. Connections between tumor development and inflammatory responses triggered by TLR activity have been elucidated, and TLR agonists are the subject of investigation for various cancer therapies. The purpose of this review is to focus on the relationship between TLR agonists and cancer and describe the underlying mechanisms that have been experimentally and clinically established about this relationship.

For more Open Access Journals in Crimson Publishers please click on: https://crimson-publishers.blogspot.com/2019/10/crimson-publishers-impact-factor.html

For more Articles in Novel Approaches in Cancer Study please click on: https://crimsonpublishers.com/nacs/index.php

[genefish]

New in Pubmed: The involvement of TLR signaling and anti-bacterial effectors in enhanced immune protection of oysters after Vibrio splendidus pre-exposure.

The involvement of TLR signaling and anti-bacterial effectors in enhanced immune protection of oysters after Vibrio splendidus pre-exposure.

Dev Comp Immunol. 2019 Sep 13;:103498

Authors: Wang W, Wang L, Liu Z, Song X, Yi Q, Yang C, Song L

Abstract The phenomena of enhanced protection of innate immunity responding to a pre-exposed pathogen have been reported in invertebrates. The underpinning molecular basis and mechanism for the enhanced immune protection are still missing. In order to explore the possible molecular basis for enhanced immune protection in molluscs, the transcriptomic analysis of oysters Crassostrea gigas hemocytes after twice stimulation of Vibrio splendidus were conducted, and a total of 403 M clean reads and 34254 differentially expressed genes (DEGs) were collected. There were 2964 common DEGs up-regulated in hemocytes after both the first and second immune stimulation, which were mostly enriched in metabolic processes and immune related pathways, such as endocytosis, MAPK signaling pathway and TLR signal pathway. Moreover, 187 and 55 DEGs were higher expressed at resting (0 h after stimulation) and activating state (12 h after stimulation) of the second immune response than that of the first response, respectively, mainly including immune recognition receptor scavenger receptor 2, signal molecule MAPK2, immune regulator IL17-d, apoptosis inhibitor IAP and effector cathepsin. More importantly, 13 DEGs were long-lastingly higher expressed at both the resting and activating state within the second immune response than that of the first, including TLR signal molecule MyD88, anti-virulent tissue inhibitor of metalloproteinase, anti-bacterial proline-rich transmembrane protein, which might play indispensable roles in enhanced immune protection against V. splendidus re-infection. The expression patterns of TLR signals (CgTLR6 and CgMyD88) and effector molecules (CgTIMP and CgPRTP) were further validated by RT-PCR, which were consistent to transcriptomic results. All the results provided an overall molecular basis of enhanced immune protection for hemocytes defensing against the second stimulation of V. splendidus in oyster, which would be valuable for understanding the protection mechanisms of pre-exposure in invertebrates.

PMID: 31525382 [PubMed - as supplied by publisher]

from pubmed: crassostrea gigas https://ift.tt/2Am7l5A via IFTTT

[turrondeluxe]

[furynewsnetwork]

LISTEN TO TLR’S LATEST PODCAST:

Chinese media, specifically Xinhua, erroneously reported that North Korea had fired a missile or projectile, a story that was picked up by other other outlets such as Bloomberg according to Zero Hedge. 

Xinhua is the official press of the Chinese government, which means that anything coming from them should be taken seriously. However, according to different reports, North Korea didn’t fire off any missiles but instead were showing off new missiles that could be fired from a submarine (SLBM).

As Zero Hedge reported:

“As expected – and feared – during the annual “Day of the Sun” celebration parade (celebrating the birth of the nation’s founder), Bloomberg blasted a headline that Chinese news agency Xinhua reported that North Korea has fired a projectile.

NORTH KOREA FIRES PROJECTILE, MEDIA SAYS: XINHUA

On its website, Bloomberg immediately picked up the story, and ran with “North Korea Fires Projectile Media, Says Xinhua” (at a url which still reads: “http://ift.tt/2oAmT0mnorth-korea-fires-projectile-media-says-xinhua“)”

Source: Zero Hedge

The link above is directed to an article about North Korea showing off their new missiles as the world wonders what will happen. A senior North Korean military official said that their country was ready for nuclear war.

If the U.S. provokes recklessly, the revolutionary forces will take an annihilating strike,” Choe Ryong Hae said in a speech.

As American warships draw near, China has been trying to play mediator while also moving closer to America. While they have stopped coal imports from North Korea and a communist paper called for stiffer sanctions against North Korea, China warned that all parties should “stop provoking.”

“Once a war really happens, the result will be nothing but losing all round and no one could become a winner,” China’s Foreign Minister Wang Yi said. “No matter who the nation is, if it continues to provoke wars in the Peninsula, it has to bear this historical responsibility and pay its price.”

WATCH TLR’S LATEST VIDEO:

The post Chinese Media Erroneously Reports North Korea Fired a Missile appeared first on The Libertarian Republic.

via Headline News – The Libertarian Republic

[healthcarebiz]

US FDA Grants Orphan Drug Designation to Yisheng Biopharma's PIKA Rabies Vaccine

BEIJING, Jan. 4, 2017 /PRNewswire/ -- Yisheng Biopharma Co., Ltd. ("Yisheng Biopharma"), a biopharmaceutical company focusing on research, development, manufacturing, sales and marketing of immuno-therapeutic products and vaccines, today announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation for its lead vaccine candidate, PIKA rabies vaccine, which is an innovative rabies vaccine independently developed by Yisheng Biopharma, using its proprietary toll-like receptor-3 (TLR-3) activation technology. This project was named a "National Key Medicine Innovation" in 2013, and is currently under Phase II clinical development.

"The orphan drug designation of our vaccine candidate for rabies prophylaxis is an important regulatory milestone as we have been working in this area for over seven years, an area where little advancement or improvement has been achieved for some time," said Yi Zhang, Chairman and Chief Executive Officer. "This product has great potential to provide superior clinical benefit to patients as compared to current rabies vaccines. As this product is already in Phase II clinical study, we look forward to working closely with the US FDA and regulatory authorities in other countries to bring this promising product to market."

Orphan drug designation is granted by the FDA Office of Orphan Products Development (OOPD) to novel drugs and biologics which are defined as those intended for the safe and effective treatment, diagnosis or prevention of rare diseases/disorders that affect fewer than 200,000 people in the U.S. The OOPD provides incentives for sponsors to develop products for rare diseases, which may include tax credits towards the cost of clinical trials and prescription drug user fee waivers. The orphan drug designation would also entitle Yisheng Biopharma to a seven-year period of marketing exclusivity in the United States pending FDA approval for the marketing clearance.

About Yisheng Biopharma Co., Ltd.

Yisheng Biopharma Co., Ltd. is a biopharmaceutical company headquartered in Beijing, China, focusing on the research, development, manufacturing and sales and marketing of immunological and vaccine products, with approximately 1000 employees in China, USA and Singapore.

www.yishengbio.com

To view the original version on PR Newswire, visit:http://ift.tt/2hQXJJh

Read this news on PR Newswire Asia website: US FDA Grants Orphan Drug Designation to Yisheng Biopharma's PIKA Rabies Vaccine

[turrondeluxe]

Seeing your turtle tots in baby clothes it's just the cutest thing ever <3 If you have the time, can you draw them in little onesies?

thank you! <3

some little pokemon warm ups!

[turrondeluxe]

They remind me of you.