#Diagnostic Devices

[jcmarchi]

Detachable cardiac pacing lead may improve safety for cardiac patients

New Post has been published on https://thedigitalinsider.com/detachable-cardiac-pacing-lead-may-improve-safety-for-cardiac-patients/

Detachable cardiac pacing lead may improve safety for cardiac patients

In 2012, Neil Armstrong, the first man to walk on the moon, died of post-surgery complications at the age of 82 following what should have been a routine heart surgery. Armstrong had undergone bypass surgery, the most common open-heart operation in the United States, and a surgery where the overall chance of death has dropped to almost zero.

Armstrong’s death was caused by heart damage that occurred during the removal of temporary cardiac pacing leads. Pacing leads are routinely used to monitor patients and protect against the risk of postoperative arrhythmias, including complete blockages, during the recovery period after cardiac surgery. However, because current methods rely on surgical suturing or direct insertion of electrodes to the heart tissue, trauma can occur during implantation and removal, increasing the potential for damage, bleeding, and device failure.

A coffee chat in 2019 about Armstrong’s untimely death helped inspire new research, published in the journal Science Translational Medicine. The research demonstrates findings that may offer a promising new platform for adhesive bioelectronic devices for cardiac monitoring, diagnosis, and treatment, and offer inspiration for the future development of bioadhesive electronics.

“While discussing the story, our team had a eureka moment that we probably could do something to prevent such complications by realizing a completely atraumatic version of it based on our bioadhesive technologies,” says Hyunwoo Yuk SM ’16, PhD ’21, a former MIT research scientist who is now the chief technology officer at SanaHeal. “It was such an exciting idea, and the rest was just making it happen.”

The team, comprising researchers affiliated with the lab of Xuanhe Zhao, professor of mechanical engineering and of civil and environmental engineering, has introduced a 3D-printable bioadhesive pacing lead that can directly interface with cardiac tissue, supporting minimally invasive adhesive implantation and providing a detachment solution that allows for gentle removal. Yuk and Zhao are the corresponding authors of the study; former MIT researcher Jue Deng is the paper’s first author.

“This work introduces the first on-demand detachable bioadhesive version of temporary cardiac pacing lead that offers atraumatic application and removal of the device with enhanced safety while offering improved bioelectronic performance,” says Zhao.

The development of the bioadhesive pacing lead is a combination of technologies that the team has developed over the last several years in the field of bioadhesive, bioelectronics, and 3D printing. SanaHeal, a company born from the team’s ongoing work, is commercializing bioadhesive technologies for various clinical applications.

“We hope that our ongoing effort on commercialization of our bioadhesive technology might help faster clinical translation of our bioadhesive pacing lead as well,” says Yuk.

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Welch Allyn CP150 12-Lead Interpretive ECG | AMA Products

The Welch Allyn CP150 is a high-performance 12-lead ECG machine designed for accuracy and ease of use. It features interpretive analysis to assist with quick and reliable diagnosis, making it ideal for both clinical and office settings.

With a user-friendly interface and compact design, it offers precise readings and seamless integration into your healthcare practice. Enhance your diagnostic capabilities with this essential medical equipment.

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Veterinary Equipment for Optimal Animal Care

In today's veterinary practices, the importance of using appropriate equipment cannot be overstated. These tools are not just aids; they are essential for providing the best possible care to our animal companions.

From diagnostic devices to surgical instruments, monitoring tools to rehabilitation equipment, the realm of veterinary equipment is diverse and vital.

This comprehensive guide will take you through the various categories of veterinary equipment, shedding light on their functionalities and significance in the field of animal care.

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[electronalytics]

Medical Grade Thermocouple Wire Market Overview and Regional Outlook Study 2017 – 2032

The market for medical grade thermocouple wire is witnessing steady growth due to the increasing demand for accurate and reliable temperature measurement in the medical industry. Thermocouples are widely used in various medical applications, including monitoring body temperature, laboratory testing, and medical equipment calibration.

Market Overview of Medical Grade Thermocouple Wire:

Technological Advancements: Advancements in thermocouple wire technology, such as the development of high-precision sensors and miniaturization, are driving the market growth. These advancements enable accurate temperature measurements in medical devices.

Healthcare Industry Expansion: The expanding healthcare industry, including hospitals, clinics, and research laboratories, is creating a substantial demand for medical grade thermocouple wire. These wires are widely used in medical devices, such as patient monitoring systems, incubators, and surgical equipment.

Stringent Regulations: The medical industry is subject to strict regulations regarding patient safety and product quality. Medical grade thermocouple wires comply with these regulations, ensuring reliability and accuracy in temperature measurement, which is a key factor driving their adoption.

Increasing Awareness: Growing awareness among healthcare professionals and researchers about the benefits of using thermocouple wires in medical applications is boosting the market. These wires offer advantages such as high accuracy, fast response time, and compatibility with various medical devices.

Key Factors Driving the Medical Grade Thermocouple Wire Market:

Rising Focus on Patient Safety: The healthcare industry's increasing emphasis on patient safety and comfort is driving the demand for medical grade thermocouple wires. These wires help in precise temperature monitoring, ensuring optimal patient care.

Growing Demand for Minimally Invasive Procedures: The rising preference for minimally invasive procedures requires accurate temperature sensing and monitoring during surgeries. Medical grade thermocouple wires enable real-time temperature measurements, enhancing the safety and success rates of such procedures.

Advancements in Medical Device Technologies: The continuous advancements in medical device technologies, such as wearable devices and remote patient monitoring systems, are fueling the demand for medical grade thermocouple wires. These wires play a crucial role in temperature sensing within these devices.

Increasing Research and Development Activities: The ongoing research and development activities in the medical field, including the development of new drugs, medical treatments, and diagnostic techniques, rely on accurate temperature measurements. Medical grade thermocouple wires are essential components in such research activities.

Growing Geriatric Population: The global increase in the geriatric population is driving the demand for medical devices and healthcare services. Medical grade thermocouple wires find extensive applications in temperature monitoring devices used for elderly care, such as patient monitors and wearable health trackers.

COVID-19 Impact: The COVID-19 pandemic has increased the demand for medical devices and equipment, including temperature monitoring systems. Thermocouple wires are used in various COVID-19-related applications, such as vaccine storage and transport, ICU patient monitoring, and fever detection systems.

Expansion of Home Healthcare: The rising trend of home healthcare services and the need for portable medical devices have led to an increased demand for medical grade thermocouple wires. These wires enable temperature monitoring in portable devices used for home healthcare purposes.

Increasing Adoption of Wireless Thermocouple Systems: The market is witnessing a shift towards wireless thermocouple systems, which offer convenience, ease of use, and reduced clutter. Medical grade thermocouple wires are an integral part of these wireless systems, driving their demand.

Collaborations and Partnerships: Key players in the medical device industry are entering into collaborations and partnerships to develop innovative solutions. Such collaborations involving medical grade thermocouple wire manufacturers contribute to market growth.

Growing Focus on Precision Medicine: The increasing focus on precision medicine, which involves personalized treatment based on individual characteristics, requires accurate temperature monitoring in various medical procedures. Medical grade thermocouple wires play a vital role in delivering precise temperature measurements for effective treatment outcomes.

We recommend referring our Stringent datalytics firm, industry publications, and websites that specialize in providing market reports. These sources often offer comprehensive analysis, market trends, growth forecasts, competitive landscape, and other valuable insights into this market.

By visiting our website or contacting us directly, you can explore the availability of specific reports related to this market. These reports often require a purchase or subscription, but we provide comprehensive and in-depth information that can be valuable for businesses, investors, and individuals interested in this market.

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Market Segmentations:

Global Medical Grade Thermocouple Wire Market: By Company • TE Wire＆Cable • Johnson Matthey • Heraeus • Sandvik (Kanthal) • BASF • OMEGA Engineering • Belden • Pelican Wire • National Instruments • Indutrade (Pentronic) • Pyromation • Dwyer Instruments • Tempco • Durex Industries • Marlin Manufacturing Corporation • Multi/Cable Corporation • Ellab • Temprel • Thermo-Electra • Hayashidenko Global Medical Grade Thermocouple Wire Market: By Type • Type T • Type K • Other Global Medical Grade Thermocouple Wire Market: By Application • Pharmaceutical Enterprise • Hospital • Other Global Medical Grade Thermocouple Wire Market: Regional Analysis All the regional segmentation has been studied based on recent and future trends, and the market is forecasted throughout the prediction period. The countries covered in the regional analysis of the Global Medical Grade Thermocouple Wire market report are U.S., Canada, and Mexico in North America, Germany, France, U.K., Russia, Italy, Spain, Turkey, Netherlands, Switzerland, Belgium, and Rest of Europe in Europe, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, China, Japan, India, South Korea, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), and Argentina, Brazil, and Rest of South America as part of South America.

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In general, market research studies offer companies and organisations useful data that can aid in making decisions and maintaining competitiveness in their industry. They can offer a strong basis for decision-making, strategy formulation, and company planning.

Medical Grade Thermocouple Wire Market Research Report Contains Answers to your following Questions

Which Manufacturing Technology is Used for Medical Grade Thermocouple Wire? What Developments Are Going On in That Technology? Which Trends Are Causing These Developments?

Who Are the Global Key Players in This Medical Grade Thermocouple Wire Market? What's Their Company Profile, Their Product Information, and Contact Information?

What Was Global Market Status of Medical Grade Thermocouple Wire Market? What Was Capacity, Production Value, Cost and PROFIT of Medical Grade Thermocouple Wire Market?

What Is Current Market Status of Medical Grade Thermocouple Wire Industry? What's Market Competition in This Industry, Both Company, and Country Wise? What's Market Analysis of Medical Grade Thermocouple Wire Market by Taking Applications and Types in Consideration?

What Are Projections of Global Medical Grade Thermocouple Wire Industry Considering Capacity, Production and Production Value? What Will Be the Estimation of Cost and Profit? What Will Be Market Share, Supply and Consumption? What about Import and Export?

What Is Medical Grade Thermocouple Wire Market Chain Analysis by Upstream Raw Materials and Downstream Industry?

What Is Economic Impact On Medical Grade Thermocouple Wire Industry?

What are Global Macroeconomic Environment Analysis Results? What Are Global Macroeconomic Environment Development Trends?

What Are Market Dynamics of Medical Grade Thermocouple Wire Market? What Are Challenges and Opportunities?

What Should Be Entry Strategies, Countermeasures to Economic Impact, Marketing Channels for Medical Grade Thermocouple Wire Industry?

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[riannatriton]

Medical Electrodes Market: Tech Trends & leading Segments

The steady rise in the number of chronic diseases reflects an urgent need for countries worldwide to establish healthcare programs, reforms and funds for the public. Due to the advancing popularity of early diagnosis and treatment, the global medical electrodes market is expected to progress at a growth rate of 4.99% during the forecast period 2022-2028.

According to a report by World Health Organization (WHO), approximately 17.9 million people died from cardiovascular diseases in 2019, accounting for nearly 32% of the global deaths. Additionally, approximately 50 million people worldwide suffer from neurological disorders such as epilepsy.

Government Initiatives: Key Driver

The geriatric population is increasing worldwide. According to a report by the UN, Population division, North America is projected to be the second most-aged region after Europe in the coming year, with 28% of the population aged 60 years and over in 2050. Such an increase in the elderly population increases the incidence of neurological and cardiovascular diseases, sleep-related disorders and other diseases.

Although with an increase in the incidence of diseases, there has been a rise in investments in the research and development of all healthcare services. According to a WHO report on Global Healthcare Expenditure, the spending reached $8.5 trillion in 2019, i.e., 9.8% of global GDP, with high-income countries accounting for about 80% of this spending. Some of the government healthcare reforms and funding initiatives are listed as follows-

Universal Health Coverage has focused on strengthening the health systems around the world. This ensures that people worldwide have access to quality healthcare without any financial hardship.

Similarly, government initiative such as Production Linked Incentive Scheme in India for Medical Devices 2020 provides a financial incentive to boost domestic manufacturing and attracts large investments in medical devices. The government also introduced Medical Devices Parks Scheme in the country to support the medical device sector.

Horizon Europe for funding research and innovation to achieve SDGs by the EU facilitates industrial competitiveness and optimizes investment impact within a strengthened European Research Area.

The Federal Ministry of Education and Research in Germany announced an increase in medical technology funding further by USD 23.7million to address the needs of Covid-19 patients and advance the healthcare system.

Such government initiatives result in increased investments in healthcare facilities. These investments result in higher production of medical electrodes due to their application in different diseases, thereby driving the growth of the studied market during the forecast period 2022-2028.

Technological Advancements - Key Opportunity

Based on application, cardiology is anticipated to drive the segment with a CAGR of 5.45% during the forecast period 2022-2028. The electrodes used in this segment are developed using different technologies. These electrodes can be dry or wet, disposable or reusable, wireless or wired, depending on the usage and type of treatment like ECG, EEG, EMG and others.

The diagnostic is expected to drive the type segment with a CAGR of 4.88% during the forecast period 2022-2028. The demand for electrodes has been growing rapidly due to technological advancements for increasing the portability of medical electrodes, the rising need for preventive medicine and the increasing number of chronic diseases.

With digitalization and technological advancements, consumer demand is changing based on new product patterns. For instance, the developments in medical electrode applications using miniaturization with the help of nanotechnology is a major trend, boosting the market growth. The process makes the electrodes portable, resulting in higher density, localized stimulation control, and greater tissue-sensing resolution.

Conclusion

The development, manufacturing, distribution and sale of medical electrodes are subject to stringent regulatory processes for their safety, quality and performance checks. They are also subjected to various environmental health and safety laws requiring proper sterilization. However, the diversified portfolio of competitors and acquisitions drives the global medical electrode market with new technology and a streamlined process. Some of the key partnerships and acquisitions are:

With the acquisition of Itamar Medical Ltd, ZOLL Medical Corporation hopes to improve communication between the fields of cardiology and sleep medicine while assisting more patients in receiving a diagnosis and treatment for sleep-disordered breathing.

Nihon Kohden acquired AMP3D to integrate the Saas platform of AMP3D into their healthcare ecosystem.

GE Healthcare acquired BK to expand GE’s Ultrasound business from diagnostics to surgical and therapeutic interventions.

Johnson and Johnson’s Ethicon business completed the acquisition of Auris Health to expand the digital surgery portfolio and bring disruptive innovation to the complete continuum of procedures, including open, laparoscopic, endoluminal and robotic.

[absentlyabbie]

going to bed before i burst into actual tears of helpless frustration because for the third time in as many weeks, my computer has decided that despite paying for 500mbps internet, i'm only allowed an oscillation between 2.4-40mbps for absolutely no valid reason, and whatever i did to somehow make it work again last time absolutely will not work this time

[creativeera]

Point of Care Diagnostics: Revolutionizing Healthcare with Real-Time Testing

The Advent of Quick and Accurate Medical Testing Point of Care Diagnostics have emerged as a groundbreaking development in the medical field by enabling accurate testing to be done quickly and conveniently. Traditional diagnostic methods usually require samples to be sent to a centralized laboratory for analysis, which can delay vital treatment decisions by several days. However, point-of-care tests provide results within minutes using portable devices, bringing testing closer to the patient. This revolutionary approach is transforming healthcare delivery. Rapid Testing for Better Patient Outcomes By facilitating timely diagnosis, point-of-care testing leads to better patient outcomes. Speedy detection of conditions like infections or chronic diseases allows doctors to prescribe appropriate treatment without delay. For example, point-of-care tests are commonly used in emergency rooms to quickly identify heart attacks, strokes or life-threatening infections. Getting fast diagnostic results is crucial for such medical emergencies as it ensures patients receive the right therapy as soon as possible. The timely administration of antibiotics, anti-clotting medications or other critical treatments improves survival rates and recovery. Patient Comfort and Convenience Besides clinical benefits, Point of Care Diagnostics enhance patient comfort and convenience. People no longer have to wait anxiously for days to learn about their health while potentially worsening conditions go untreated. With devices that analyze samples on-site, patients get actionable results during the same clinical visit when treatment decisions are made. This spares them follow-up trips to the doctor or lab and unnecessary stress. Home testing using self-administered point-of-care kits even allows monitoring health remotely while maintaining independence. Finger-prick blood samples or urine specimens are all that's needed, eliminating difficulties obtaining specimens. More Efficient Use of Resources Speedy diagnostic testing optimizes use of limited healthcare resources. Quick turnaround times avoid unnecessary reliance on expensive treatments initiated just to address uncertainty in diagnoses. Point-of-care devices reduce laboratory workloads too by decentralizing testing. Moreover, decentralized testing is vital for resource-constrained settings like rural areas, refugee camps or developing countries where access to centralized labs is limited. Portable devices overcome infrastructure barriers and enable basic medical services even in remote areas. This promotes healthcare equity globally. A Proliferation of Diagnostic Platforms Rapid technological progress has enabled the development of varied point-of-care testing systems. Examples include paper microfluidic devices, electrochemical sensors, molecular diagnostics platforms and portable ultrasound machines integrated with imaging analysis software. Immunology-based tests detecting proteins or antibodies through lateral flow or microarray methods are commonly used for conditions like infections and cardiac markers. Molecular diagnostic platforms employ techniques like polymerase chain reaction (PCR) for swift nucleic acid amplification and analysis of viruses or genetic markers. Newer technologies like CRISPR gene editing also hold promise as a basis for point-of-care genetic testing. With ongoing research, the types of conditions examinable at the point of care continue expanding in scope and complexity. Get more insights on Point Of Care Diagnostics

Also read related article on Gastroesophageal Reflux Disease Treatment Devices Market

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[alt-ctrl]

The Simplicity Revolution: How Healthcare is Getting a Much-Needed Makeover

In a world where complexity seems to reign supreme, healthcare is taking an unexpected turn towards simplicity. Who would have thought that in an industry known for its labyrinthine processes and cryptic jargon, the next big thing would be... simplification? It's like watching a Rube Goldberg machine suddenly transform into a sleek, minimalist sculpture. But don't be fooled - this simplicity revolution is anything but simple.

The Paradox of Simplifying Complexity

Healthcare, much like a tangled ball of Christmas lights, has long been a source of frustration for patients and providers alike. But fear not, dear reader, for the elves of innovation are hard at work, untangling this mess one strand at a time. And they're doing it in ways that might make you scratch your head and say, "Why didn't we think of this before?"

Telemedicine: When "House Calls" Go Digital

Remember the good old days when doctors made house calls? Well, they're back - sort of. Telemedicine is like the love child of a house call and a Zoom meeting. It's bringing healthcare to your living room, minus the doctor's signature on your sofa cushions.

Imagine this: You're sitting in your pajamas, hair a mess, sipping coffee, when suddenly - poof! - your doctor appears on your screen. It's like magic, but with more stethoscopes and less top hats. This digital house call is not just convenient; it's a game-changer for rural patients who can now access specialized care without embarking on an "Oregon Trail"-style journey.

Electronic Health Records: Your Medical History, Minus the Library

Remember when your medical history was a mysterious tome, locked away in some dusty filing cabinet? Electronic Health Records (EHRs) are here to change that narrative. It's like someone took your entire medical history and turned it into a binge-worthy Netflix series - easily accessible, shareable, and much less likely to be lost in a flood.

But here's the real plot twist: EHRs are not just about digitizing paper. They're about freeing up healthcare providers to do what they do best - care for patients. It's as if we've given doctors a magic wand that turns paperwork into patient time. Abracadabra, indeed!

Mobile Health Apps: Your Pocket-Sized Health Guru

If you thought your smartphone was just for scrolling through cat videos and arguing with strangers on the internet, think again. Mobile health apps are turning our phones into pocket-sized health gurus. It's like having a tiny, very knowledgeable doctor living in your phone, minus the expensive medical school bills.

Take diabetes management apps, for example. They're like having a personal nutritionist, fitness trainer, and endocrinologist all rolled into one, living in your pocket. They remind you to check your blood sugar, suggest what to eat, and even tattle on you to your doctor if you're not behaving. It's like having a health-conscious Jiminy Cricket, but with better data plans.

Wearable Health Devices: When Your Watch Knows More About Your Health Than You Do

Welcome to the future, where your watch doesn't just tell time - it tells you when it's time to see a doctor. Wearable health devices are like having a tiny, very attentive nurse strapped to your wrist. They monitor your vitals with the dedication of a helicopter parent, but with more beeps and fewer guilt trips.

Imagine a world where your watch can detect an irregular heartbeat before you even feel it. It's like having a tiny cardiologist living on your wrist, constantly on the lookout for trouble. Who knew that the path to better health would involve accessorizing?

AI-Driven Diagnostic Tools: When Machines Become Medical Detectives

Move over, Sherlock Holmes. There's a new detective in town, and it's powered by artificial intelligence. AI-driven diagnostic tools are like giving a supercomputer a medical degree and a deerstalker hat. They can spot anomalies in medical images faster than you can say "elementary, my dear Watson."

Picture this: You go in for a routine scan, and while the human radiologist is still sipping their first coffee of the day, the AI has already analyzed your images, flagged potential issues, and probably planned your treatment schedule. It's like having a medical savant on your side, minus the social awkwardness often portrayed in medical dramas.

The Plot Twist: Simplicity is Complex

As we navigate this brave new world of simplified healthcare, we must remember that achieving simplicity is, paradoxically, a complex endeavor. It requires rethinking entire systems, challenging long-held beliefs, and sometimes, teaching old docs new tricks.

But here's the million-dollar question: In our quest for simplicity, are we overlooking the beautiful complexity of human health? As we automate and streamline, are we at risk of losing the human touch that has long been the cornerstone of healthcare?

As we marvel at these innovations, let's not forget that at the heart of healthcare are human beings - complex, unpredictable, and wonderfully diverse. The true challenge lies in harnessing the power of simplicity while honoring the intricate tapestry of human health.

In the end, the simplicity revolution in healthcare isn't about dumbing things down - it's about smartening things up. It's about making healthcare more accessible, more efficient, and dare we say, more human. Now, isn't that a plot twist worth exploring?

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[swapnamakro]

QMS & Risk Management for IVD Manufacturers

IVD manufacturers must comply with strict regulations to ensure product safety and quality. A well-implemented Quality Management System (QMS) and risk management strategy help manufacturers meet regulatory standards, minimize risks, and improve overall product reliability. This content offers insights on regulatory frameworks like ISO 13485 and FDA 21 CFR Part 820, designed to support manufacturers in the medical diagnostics industry.

For more info: https://www.makrocare.com/blog/developing-and-maintaining-a-qms-for-ivds/

[jcmarchi]

Understanding why autism symptoms sometimes improve amid fever

New Post has been published on https://thedigitalinsider.com/understanding-why-autism-symptoms-sometimes-improve-amid-fever/

Understanding why autism symptoms sometimes improve amid fever

Scientists are catching up to what parents and other caregivers have been reporting for many years: When some people with autism spectrum disorders experience an infection that sparks a fever, their autism-related symptoms seem to improve.

With a pair of new grants from The Marcus Foundation, scientists at MIT and Harvard Medical School hope to explain how this happens in an effort to eventually develop therapies that mimic the “fever effect” to similarly improve symptoms.

“Although it isn’t actually triggered by the fever, per se, the ‘fever effect’ is real, and it provides us with an opportunity to develop therapies to mitigate symptoms of autism spectrum disorders,” says neuroscientist Gloria Choi, associate professor in the MIT Department of Brain and Cognitive Sciences and affiliate of The Picower Institute for Learning and Memory.

Choi will collaborate on the project with Jun Huh, associate professor of immunology at Harvard Medical School. Together the grants to the two institutions provide $2.1 million over three years.

“To the best of my knowledge, the ‘fever effect’ is perhaps the only natural phenomenon in which developmentally determined autism symptoms improve significantly, albeit temporarily,” Huh says. “Our goal is to learn how and why this happens at the levels of cells and molecules, to identify immunological drivers, and produce persistent effects that benefit a broad group of individuals with autism.”

The Marcus Foundation has been involved in autism work for over 30 years, helping to develop the field and addressing everything from awareness to treatment to new diagnostic devices.

“I have long been interested in novel approaches to treating and lessening autism symptoms, and doctors Choi and Huh have honed in on a bold theory,” says Bernie Marcus, founder and chair of The Marcus Foundation. “It is my hope that this Marcus Foundation Medical Research Award helps their theory come to fruition and ultimately helps improve the lives of children with autism and their families.”

Brain-immune interplay

For a decade, Huh and Choi have been investigating the connection between infection and autism. Their studies suggest that the beneficial effects associated with fever may arise from molecular changes in the immune system during infection, rather than on the elevation of body temperature, per se.

Their work in mice has shown that maternal infection during pregnancy, modulated by the composition of the mother’s microbiome, can lead to neurodevelopmental abnormalities in the offspring that result in autism-like symptoms, such as impaired sociability. Huh’s and Choi’s labs have traced the effect to elevated maternal levels of a type of immune-signaling molecule called IL-17a, which acts on receptors in brain cells of the developing fetus, leading to hyperactivity in a region of the brain’s cortex called S1DZ. In another study, they’ve shown how maternal infection appears to prime offspring to produce more IL-17a during infection later in life.

Building on these studies, a 2020 paper clarified the fever effect in the setting of autism. This research showed that mice that developed autism symptoms as a result of maternal infection while in utero would exhibit improvements in their sociability when they had infections — a finding that mirrored observations in people. The scientists discovered that this effect depended on over-expression of IL-17a, which in this context appeared to calm affected brain circuits. When the scientists administered IL-17a directly to the brains of mice with autism-like symptoms whose mothers had not been infected during pregnancy, the treatment still produced improvements in symptoms.

New studies and samples

This work suggested that mimicking the “fever effect” by giving extra IL-17a could produce similar therapeutic effects for multiple autism-spectrum disorders, with different underlying causes. But the research also left wide-open questions that must be answered before any clinically viable therapy could be developed. How exactly does IL-17a lead to symptom relief and behavior change in the mice? Does the fever effect work in the same way in people?

In the new project, Choi and Huh hope to answer those questions in detail.

“By learning the science behind the fever effect and knowing the mechanism behind the improvement in symptoms, we can have enough knowledge to be able to mimic it, even in individuals who don’t naturally experience the fever effect,” Choi says.

Choi and Huh will continue their work in mice seeking to uncover the sequence of molecular, cellular and neural circuit effects triggered by IL-17a and similar molecules that lead to improved sociability and reduction in repetitive behaviors. They will also dig deeper into why immune cells in mice exposed to maternal infection become primed to produce IL-17a.

To study the fever effect in people, Choi and Huh plan to establish a “biobank” of samples from volunteers with autism who do or don’t experience symptoms associated with fever, as well as comparable volunteers without autism. The scientists will measure, catalog, and compare these immune system molecules and cellular responses in blood plasma and stool to determine the biological and clinical markers of the fever effect.

If the research reveals distinct cellular and molecular features of the immune response among people who experience improvements with fever, the researchers could be able to harness these insights into a therapy that mimics the benefits of fever without inducing actual fever. Detailing how the immune response acts in the brain would inform how the therapy should be crafted to produce similar effects.

“We are enormously grateful and excited to have this opportunity,” Huh says. “We hope our work will ‘kick up some dust’ and make the first step toward discovering the underlying causes of fever responses. Perhaps, one day in the future, novel therapies inspired by our work will help transform the lives of many families and their children with ASD [autism spectrum disorder].”

[amaproducts]

Welch Allyn Durashock DS66 Aneroid Sphygmomanometer with Adult Flexiport Cuff | AMA Products

The Welch Allyn DS66 Multi-Cuff Sphygmomanometer Kit offers precision and versatility for accurate blood pressure measurement. This comprehensive kit includes four cuffs—large adult, adult, small adult, and child—ensuring a perfect fit for various patient sizes.

Designed for healthcare professionals, the durable and easy-to-use sphygmomanometer is ideal for both clinical and home settings.

Enhance your medical equipment collection with this reliable and high-quality sphygmomanometer kit.

[anthonyhoffmansworld]

Top CE Marked Medical Devices And Diagnostic Equipment

Discover premier CE-marked medical devices and diagnostic equipment, ensuring top-tier quality and safety standards. Explore reliable tools designed for accurate diagnostics and effective patient care, all compliant with rigorous European regulations.

[dashtechnologiesinc]

Surgical Innovation & Medical Device Diagnostic Applications

We’ve engaged in device firmware, EMR/EHR integration, digitized & automated operation room workflow, ensuring data security with HIPAA & FDA compliances. More - https://dashtechinc.com/blog/transformative-technologies-advancing-patient-care-through-next-gen-embedded-medical-device-software-development/