#Medullary thyroid cancer

[tockamybeloved]

[atassociation12]

https://www.thyroid.org/

The American Thyroid Association® (ATA) is the professional home for clinicians and researchers dedicated to thyroid health. Learn more and join us.

[myhealingera]

Two weeks after this photo was taken, I received a phone call that nobody ever wants to receive.

I was dealing with a slew of health issues: an inability to lose weight, hair loss, swollen lymph nodes, fatigue so intense that getting out of bed felt like a miracle, and severe brain fog. My joints were in so much pain that I found myself using a heating pad for most of the day.

I consulted my aunt, who is a pediatrician, and she reviewed my recent blood work. She observed that my TSH levels were consistently borderline high, often surpassing the normal threshold. Encouraged by her insight, I visited my OBGYN and shared my symptoms. She ordered hormone testing and referred me to a rheumatologist, given that lupus runs in my family. The results indicated elevated TSH, DHEA, and C-reactive protein levels.

I then saw a remarkable rheumatologist who conducted over 120 tests. All came back normal except for my thyroid antibodies, and I was diagnosed with arthritis in my hands. Around this time, my neck began to swell, feeling as though something was stuck in my throat. My primary care physician scheduled an ultrasound, which revealed swelling in my neck and a lymph node, and identified a nodule or "ectopic" tissue.

Returning to my primary care doctor, I was told my lab results were normal and advised to follow up in a year, despite continuing to experience swollen lymph nodes and being told that the neck nodule was unrelated to the swelling. At this point had been to urgent care 3 times, completed 3 rounds of steroids, a z-pack, and tested negative for mono, Covid, and strep.

Despite my tendency to avoid conflict, something felt off, and I knew I wasn't okay.

I requested a referral to an endocrinologist, which I received, but they couldn't see me until after Christmas. Not wanting to wait, I found another endocrinologist who could see me on Halloween. At my first appointment, I was diagnosed with Hashimoto’s thyroiditis and hypothyroidism. She ordered a biopsy "to be safe," emphasizing that a finding warrants investigation. Even at the hospital for my biopsy, the PA questioned its necessity given my primary care's advice to wait a year.

On 12/22, my endocrinologist informed me that the biopsy results were suspicious for thyroid carcinoma. I returned on 1/5 to discuss the findings.

They had sent my sample for Afirma testing, a genetic test for medullary thyroid cancer, due to the unusual results and the aggressive nature of the potential cancer.

I was then referred to an ENT, who suspected the nodule might actually be a lymph node. A CT scan confirmed this suspicion, revealing a lymph node suspicious for thyroid cancer, yet with no nodules on my thyroid itself.

The decision was made to remove the lymph node, with intraoperative pathology consultation to decide whether to also remove the thyroid.

On 2/24, the lymph node was removed, but pathology was indeterminate, leading to the decision not to remove the thyroid.

The following week, I was informed that my results had been sent to a larger university hospital for further analysis and a second opinion, an ominous sign according to my ENT.

Ultimately, it was confirmed as papillary thyroid cancer that had begun to metastasize to the lymph nodes, indicating occult thyroid cancer, typically undetected until it spreads to the lymph nodes. Likely, there are microcarcinomas on my thyroid undetectable by imaging. Thus, another surgery is required.

My complete thyroidectomy is scheduled for 4/24.

Honestly, none of this truly sank in until I received a call from the hospital's oncology department to schedule a radiation consultation for post-surgery RAI treatment.

It’s been an incredibly tough start to the year, to say the least.

[a-scientific-spirituality]

I have cancer. And not much else.

I am 40.

I got sick in my late 20's. I didn't know what was wrong, I went to doctors and nothing. I blamed stress, I had to drop out of graduate school and figure out living. I ended my marriage, and moved to Denver.

I remarried some time later... and my wife started getting very sick. I continued getting sticker. I was finally diagnosed with medullary thyroid cancer at 35. Incurable. So - I prepared for the worst.

5 months later my wife was injured in a post-surgical -care accident and spent 4 years in a wheelchair.

9 months after she regained the ability to walk, I was diagnosed with ocular melanoma. Five days after that she left. Not because I was sick. But she didn't need me anymore. I don't know if it was ever real

All that aside...I'm 40 now, living at my father's farm in rural Iowa. I'm stranded. I spent Christmas and new years in detox or here as I could not find a doctor in Iowa who would prescribe my bupenorphine while I used Iowa medical Marijuana. I hate it here so much. Over half of my take home income goes immediately out the door to my ex wife.

So... here I am. 2 months now out here. It's COLD on a level Denver wasn't. It's lonely and I miss my partner and my cats and my life in Denver.

I've been pondering the contents of this blog for 30 years. I think I have it sorted now. I've not got much else to do.

Mostly this is something to keep me busy. And i guess it gives me hope. If it gives you hope then I am grateful for that chance.

[snowandstarlight]

okay i mostly use this tag to complain but i figured i’d contribute something semi-educational for once

i’m sure I’m not the first one to think of this (the first one is straight from First Aid), but here’s how i remember the different Multiple Endocrine Neoplasias

MEN I - Ps

     Parathyroid hyperplasia

     Pituitary adenomas

     Pancreatic neuroendocrine tumors

MEN IIa - Cs

     Medullary thyroid cancer (from parafollicular C cells, secretes Calcitonin)

     Parathyroid hyperplasia (elevated Calcium)

     Pheochromocytoma (produces Catecholamines)

MEN IIb - Ms

      Medullary thyroid cancer

     Pheochromocytoma (diagnosed with elevated plasma Metanephrines)

     Marfanoid habitus

     Mucosal neuromas

[impomed]

Selpercatinib 40 & 80 mg has transformed cancer treatment in India by specifically targeting RET gene mutations. It provides a more precise therapy option for patients with non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC), and RET fusion-positive thyroid cancers. Selpercatinib 40 & 80 mg in India available through Impomed Healthcare, this targeted therapy provides a personalized, effective, and well-tolerated option, marking a new era in India's oncology care.   

For more information click on this link-:https://www.impomedhealthcare.com/

[twinkl22004]

“Medullary Thyroid Carcinoma”, Victor McKusick, Mendelian Inheritance in Man, 1966.

Here I present: “Medullary Thyroid Carcinoma”, Victor McKusick, Mendelian Inheritance in Man’, 1966. INTRODUCTION. Medullary thyroid carcinoma (MTC) is a form of thyroid carcinoma which originates from the parafollicular cells (C cells), which produce the hormone calcitonin.   MTC was first characterized in 1959; and, is the third most common of all thyroid cancers. There is evidence familial…

[theindianpharma]

Cabozantinib, a tyrosine kinase inhibitor (TKI) is used for treating several types of cancer, including renal cell carcinoma (RCC), medullary thyroid cancer (MTC), and hepatocellular carcinoma (HCC).

[medchemexpressinhibitor-blog]

Unlocking the Potential of Pralsetinib: Key Facts You Should Know

In the realm of targeted cancer therapies, Pralsetinib has emerged as a groundbreaking option for patients with certain types of tumors. This innovative treatment has generated significant interest due to its specific action against genetic mutations that drive cancer growth. In this article, we will explore essential facts about Pralsetinib, including its mechanism of action, indications, safety profile, and impact on patient care.

1. What is Pralsetinib?

Pralsetinib is an oral tyrosine kinase inhibitor designed specifically to target rearranged during transfection (RET) alterations in various cancers. It has been approved for the treatment of adult patients with advanced or metastatic RET fusion-positive non-small cell lung cancer (NSCLC) and medullary thyroid cancer (MTC). By focusing on these specific mutations, Pralsetinib offers a precision medicine approach to cancer treatment.

2. Mechanism of Action

The efficacy of Pralsetinib lies in its ability to selectively inhibit the RET protein, which plays a significant role in cellular signaling pathways involved in tumor growth and survival. By blocking this pathway, Pralsetinib effectively disrupts the signals that promote cancer cell proliferation, leading to reduced tumor growth and improved patient outcomes. This targeted approach minimizes damage to healthy cells, which is a notable advantage over conventional chemotherapy.

3. Indications for Use

Pralsetinib is primarily indicated for:

Non-Small Cell Lung Cancer (NSCLC): Specifically for patients with RET fusion-positive NSCLC who have not received prior systemic therapy.

Medullary Thyroid Cancer (MTC): For patients with advanced MTC who require systemic therapy.

By addressing these specific malignancies, Pralsetinib provides a vital treatment option for patients with limited alternatives.

4. Safety Profile

Understanding the safety profile of Pralsetinib is crucial for healthcare providers and patients alike. In clinical studies, Pralsetinib has been generally well-tolerated, with common side effects including:

Fatigue

Nausea

Diarrhea

Hypertension

While most side effects are manageable, it is essential for patients to communicate openly with their healthcare team to monitor any adverse reactions and adjust treatment as necessary.

5. Administration and Dosage

Pralsetinib is administered orally, usually taken once daily. The specific dosage may vary based on individual patient factors and should be determined by a healthcare provider. This convenient oral formulation allows for flexible dosing schedules, enhancing patient adherence to treatment regimens.

6. The Future of Cancer Treatment

As research continues, the future of Pralsetinib looks promising. Ongoing clinical trials are exploring its effectiveness in additional cancer types with RET alterations and assessing combination therapies to enhance its therapeutic impact. As our understanding of targeted therapies evolves, Pralsetinib may play a pivotal role in shaping the future of personalized cancer care.

Conclusion

Pralsetinib represents a significant advancement in the treatment of RET-altered cancers, offering a targeted approach that improves patient outcomes while minimizing side effects. Its specific indications for non-small cell lung cancer and medullary thyroid cancer underscore its importance in oncology.

For patients eligible for Pralsetinib, discussing this treatment option with a healthcare provider can provide valuable insights into its benefits and potential role in their cancer management plan. As we continue to uncover the potential of targeted therapies, Pralsetinib stands out as a beacon of hope for many individuals battling cancer. Stay informed about ongoing developments and consider the possibilities that Pralsetinib brings to modern cancer treatment.

Please visit MedChemExpress https://www.medchemexpress.co

[tockamybeloved]

Another year as a Meddie survivor! Medullary Thyroid Cancer | ThyCa: Thyroid Cancer Survivors' Association, Inc.

[drsupreetbhatt]

Explore Thyroid Cancer Types: Papillary, Follicular, Medullary, Anaplastic. Knowledge empowers better decisions for treatment and care.

For more details, visit us at https://drsupreetbhatt.com/thyroid-tumor-surgery-in... CALL:- (099092 88099)

[oncologistseemasingh]

Learn about the different types of thyroid cancer, including papillary, follicular, medullary, and anaplastic. Explore this comprehensive guide to gain insights into the diverse nature of thyroid cancer.

[thyroidsurgeryuae-blog]

Understanding Parathyroid Disease: Symptoms, Diagnosis, and Treatment Options

Thyroid cancer is an increasingly prevalent health issue in the Middle East, reflecting both regional Thyroid Cancer Middle East advancements and changing epidemiological patterns. The thyroid gland, located at the base of the neck, plays a vital role in metabolism regulation through hormone production. When malignant cells form in this gland, it leads to thyroid cancer, which can be categorized into several types: papillary, follicular, medullary, and anaplastic thyroid cancer.

Papillary thyroid cancer is the most common and generally the most treatable form, while anaplastic thyroid cancer is rare but highly aggressive. The rising incidence of thyroid cancer in the Middle East can be attributed to several factors, including improved diagnostic capabilities, increased awareness, and possibly environmental and genetic factors unique to the region.

The availability of advanced diagnostic tools such as high-resolution ultrasound and fine-needle aspiration biopsy has significantly contributed to early detection and diagnosis. These tools allow healthcare professionals to identify and evaluate thyroid nodules more effectively, leading to earlier and more accurate diagnoses.

In the Middle East, there is also a growing emphasis on public health initiatives aimed at increasing awareness about thyroid cancer. Educational campaigns stress the importance of regular check-ups and early detection, which are crucial for effective treatment. Additionally, access to Best Thyroid Center UAE specialized care and improved medical infrastructure has enhanced treatment outcomes.

Environmental factors, such as dietary iodine intake, have also been linked to thyroid health. In some parts of the Middle East, variations in iodine consumption due to dietary habits may influence the prevalence of thyroid disorders, including cancer. Genetic predispositions, influenced by the region’s demographic and hereditary patterns, are another area of ongoing research.

Treatment for thyroid cancer typically involves a combination of surgery, radioactive iodine therapy, and hormone replacement therapy. The success rates are generally high, especially for the more common and less aggressive forms of the disease. However, continuous monitoring and follow-up care are essential to manage potential recurrences and long-term health outcomes.

In conclusion, Thyroid Cancer Middle East is a growing concern, but advancements in medical diagnostics, increased awareness, and improved healthcare infrastructure are contributing to better outcomes for patients. Ongoing research into the unique environmental and genetic factors in the region will further aid in understanding and combating this disease.

[retevmocapsule]

Retevmo Available in Afghanistan, Bangladesh,Bhutan,India Maldives, Nepal

The drug Selpercatinib is sold under the brand name Retevmo which is used to treat metastatic RET fusion-positive non-small cell lung carcinoma, advanced or metastatic RET-mutant medullary thyroid ca, carcinoma, advanced or metastatic RET fusion-positive thyroid cancer. This medicine is supplied in 40 mg and 80 mg capsules for oral administration. Selpercatinib may be taken with or without food unless coadministered with a proton pump inhibitor (PPI).

The drug Selpercatinib is a kinase inhibitor. Selpercatinib inhibited wild-type RET and multiple mutated RET isoforms and VEGFR1 and VEGFR3 with IC50 values ranging from 0.92 nM to 67.8 nM. Healthcare professionals recommend this medicine for the treatment of metastatic RET fusion-positive non-small cell lung cancer, advanced or metastatic RET-mutant medullary thyroid cancer, and advanced or metastatic RET fusion-positive thyroid cancer. The recommended dosage of Selpercatinib is based on body weight is:

Less than 50 kg: 120 mg

50 kg or greater: 160 mg One should take Selpercatinib orally twice daily until disease progression or unacceptable toxicity. Swallow the capsules whole. One should not crush or chew the capsules.

The medicine Retevmo contains the active ingredient Selpercatinib, a kinase inhibitor that is used in the treatment of advanced or metastatic RET-mutant medullary thyroid cancer, metastatic RET fusion-positive non-small cell lung cancer, and advanced or metastatic RET fusion-positive thyroid cancer. Selpercatinib is supplied in capsules of 40 mg and 80 mg for oral intake.

Retevmo medicine is recommended for the treatment of patients with metastatic RET fusion-positive non-small cell lung cancer, advanced or metastatic RET-mutant medullary thyroid cancer, and advanced or metastatic RET fusion-positive thyroid cancer. Retevmo capsules come in 40 mg and 80 mg for oral administration. The common side-effects of Retevmo are edema, diarrhea, fatigue, dry mouth, hypertension, abdominal pain, constipation, rash, nausea, and headache.

The drug Selpercatinib is sold under the trade name Retevmo. Healthcare professionals use this drug in treating metastatic RET fusion-positive non-small cell lung cancer, advanced or metastatic RET-mutant medullary thyroid cancer, and advanced or metastatic RET fusion-positive thyroid cancer. Selpercatinib is a kinase inhibitor, and it is a white to light yellow powder that is slightly hygroscopic.

[drkamath]

What is Thyroid Cancer? & Treatment after Thyroid Cancer Surgery in Bangalore By Dr.Anil Kamath

Ever found yourself wondering about the little butterfly-shaped gland in your neck? That’s your thyroid, and while it’s small, it plays a huge role in your overall health. Sometimes, things can go awry, leading to conditions like thyroid cancer. Let’s dive into what thyroid cancer is, how it’s treated, especially after surgery, and why Dr. Anil Kamath in Bangalore is a top choice for this critical care.

Understanding Thyroid Cancer

What is thyroid cancer?

Thyroid cancer occurs when cells in the thyroid gland grow uncontrollably. The thyroid, located at the base of your neck, produces hormones that regulate your metabolism, heart rate, and body temperature.

Types of thyroid cancer

There are several types of thyroid cancer, each with unique characteristics:

Papillary thyroid cancer: The most common type, accounting for about 80% of cases.

Follicular thyroid cancer: Less common but still a significant proportion.

Medullary thyroid cancer: Develops from thyroid cells that produce calcitonin.

Anaplastic thyroid cancer: The rarest and most aggressive form.

Symptoms of thyroid cancer

Early thyroid cancer might not show any symptoms, but as it progresses, you might notice:

A lump in the neck

Difficulty swallowing

Hoarseness or changes in your voice

Persistent cough not associated with a cold

Swollen lymph nodes in the neck

Causes and Risk Factors

Genetic factors

Certain genetic mutations can increase your risk of developing thyroid cancer. Family history plays a role, particularly in medullary thyroid cancer.

Environmental and lifestyle factors

Exposure to high levels of radiation, particularly during childhood, is a known risk factor. Diets low in iodine can also contribute to the risk.

Other risk factors

Age and gender can influence your risk, with women and people over 40 being more susceptible. Pre-existing thyroid conditions and certain hereditary syndromes also elevate the risk.

Diagnosis of Thyroid Cancer

Initial medical consultation

If you suspect you have thyroid issues, start with a visit to your healthcare provider. They’ll take a detailed history and perform a physical exam to feel for lumps or abnormalities.

Diagnostic tests and imaging

To get a clearer picture, your doctor might order tests such as:

Ultrasound: To visualize the thyroid gland and identify any nodules.

CT or MRI scans: To determine the extent of the cancer.

Blood tests: To check for abnormal levels of thyroid hormones and calcitonin.

Biopsy procedures

A fine-needle aspiration biopsy is often performed to take a sample of thyroid tissue. This sample is then examined under a microscope to confirm the presence of cancer cells.

Stages of Thyroid Cancer

Early-stage thyroid cancer

In the early stages, the cancer is confined to the thyroid gland. Treatment at this stage is generally very successful.

Advanced-stage thyroid cancer

The cancer has spread beyond the thyroid to nearby tissues and possibly lymph nodes. Treatment becomes more complex and may involve a combination of therapies.

Metastatic thyroid cancer

This is when the cancer has spread to distant parts of the body, such as the lungs or bones. Treatment focuses on managing symptoms and slowing the spread of the disease.

Treatment Options for Thyroid Cancer

Surgical interventions

Surgery is often the first line of treatment. The main types of thyroid surgery include:

Thyroidectomy: Removal of all or part of the thyroid gland.

Lobectomy: Removal of one lobe of the thyroid gland.

Radioactive iodine therapy

After surgery, radioactive iodine therapy is often used to destroy any remaining cancerous tissue. It’s particularly effective for papillary and follicular thyroid cancers.

External radiation therapy

For more aggressive types of thyroid cancer, external beam radiation might be necessary. This therapy targets cancer cells with high-energy rays.

Chemotherapy and targeted therapy

Chemotherapy is not commonly used for thyroid cancer, but it may be necessary for advanced cases. Targeted therapies, like tyrosine kinase inhibitors, can be effective for certain types of thyroid cancer.

Thyroid Cancer Surgery

Types of thyroid surgery

Depending on the extent of the cancer, your surgeon might recommend:

Total thyroidectomy: Removal of the entire thyroid gland.

Partial thyroidectomy: Removal of a portion of the thyroid gland, usually a lobe.

Preparing for surgery

Preparation involves routine blood tests, imaging, and sometimes a special diet. Your doctor will give you specific instructions to follow.

What to expect during surgery

Thyroid surgery is typically performed under general anesthesia. The procedure can take several hours, and most patients stay in the hospital for one or two days post-surgery.

Post-Surgery Treatment and Care

Post-operative care

After surgery, you’ll need to take care of the incision site, watch for signs of infection, and manage pain with prescribed medications.

Hormone replacement therapy

Since the thyroid produces essential hormones, you’ll likely need hormone replacement therapy. This involves taking daily thyroid hormone pills to maintain normal body functions.

Monitoring and follow-up care

Regular follow-up visits are crucial to monitor hormone levels and check for any signs of cancer recurrence. Your doctor will adjust your medication as needed.

Living with Thyroid Cancer

Managing side effects

Side effects from treatment can include fatigue, changes in appetite, and mood swings. A comprehensive care plan will help manage these effects.

Diet and lifestyle changes

Eating a balanced diet and maintaining a healthy lifestyle can support your recovery and overall health. Your doctor may recommend specific dietary adjustments.

Emotional and psychological support

Coping with cancer can be challenging. Seeking support from friends, family, or professional counselors can provide emotional relief and practical advice.

Why Choose Dr. Anil Kamath for Thyroid Cancer Treatment?

Dr. Kamath’s expertise and experience

Dr. Anil Kamath is a leading oncologist with extensive experience in treating thyroid cancer. His approach combines advanced medical techniques with compassionate patient care.

Success stories and patient testimonials

Patients treated by Dr. Kamath often share their positive experiences and successful outcomes, highlighting his skill and dedication.

Advanced technology and facilities

Dr. Kamath’s clinic in Bangalore is equipped with state-of-the-art technology, ensuring patients receive the highest standard of care.

Preventive Measures and Early Detection

Routine check-ups and screenings

Regular medical check-ups and thyroid screenings can help detect abnormalities early, improving treatment outcomes.

Awareness and education

Being informed about thyroid cancer symptoms and risk factors can lead to earlier diagnosis and treatment. Educational efforts can significantly raise awareness.

Conclusion

Understanding thyroid cancer and the importance of early detection can save lives. With the expertise of specialists like Dr. Anil Kamath, patients in Bangalore have access to top-tier care. Don’t wait for symptoms to escalate — proactive healthcare and regular screenings are your best defense.