#Pathway analysis

[maximum-rex]

Hello I am violently back with Stardust Rhapsody content thoughts after a brief repose, spoilers for. Literally the entire thing if you're not done with it yet.

Specifically I would like to talk about the dynamic between Pyke and Rex and the difference in how they perceived themselves in relation to the other. Some of this is influenced by the fact that some of the backstory seemed to develop during the play itself while some seemed premeditated, and I would like to state for the record I am not on the discord and don't have access to the behind the scenes to a lot of this. I just podcast listen A Lot for the moment so feel free to chip in but these are MY thoughts on the matter atm. And i'll also say this is more about In Universe characterisation than player character/NPC motivations.

Since the very first moment Rex is mentioned, Pyke makes it clear he is Not A Fan. But more than that, he makes it clear he thinks of Rex as some.soet of cheap imitation, a liar, and a joke. He constantly refers to him as a Jackass and, by name itself, a poseur. The amount of sheer disdain present in Pyke towards Rex from the very first instant is fascinating to me.

When we get the rendition of Pyke's backstory with Rex and the Pathway, he talks about the fact that Rex in the beginning was better than him. Consistently. A natural winner and competitor, raw talent from the get-go. Pyke only got an edge after Khan saw and nurtured something in Pyke,the very same thing that lead to him later leaving to pursue the path of the Sun Soul Monk. It was this that allowed Pyke to start winning. But, as Mace says consistently which conflicts with this rendition of events is that Pyke continued to lose sometimes. Pyke said that after that he never lost, but Mace says that Rex was a continued competitor. It became a much steeper fight and Pyke won a lot, but Rex continued to be his greatest opponent and contender to take his spot. Sometimes he did take his spot!

Now before I get to a conclusion on this let us look at how Rex acts towards Pyke.

From the first interaction we see between them, Rex treats Pyke, in my own opinion, very well! He approaches at speed and the first thing he does,besides his incredibly cool kick flip manoeuvre, is to give Pyke a lit cigarette. A gift. One that Pyke couldn't obtain himself without that help, as evidenced by his attempt to light one just before this and failing miserably. Despite the fact he immediately sped off and offered what seemed like joking or hollow encouragement for them to catch him, he still offered Pyke that cig.

And more than that, he took legitimate precautions on the assumption that they would catch up. Not a passing fancy or a faint suspicion, he was ready and waiting for them when they arrived at the temple. He took Pyke, and by extension the Rhapsody crew, seriously. Which is more than can be said of Pyke, at least in the surface level. He prepared traps, and a greeting, and when they do finally catch up to him, he says he expected them at least ten minutes sooner based on when they arrived in the temple. He had what appears to be an absolute faith that they not only would reach the temple, hence the trap, but also continue to pursue him at speed.

And when they begin to talk, Rex is by my account polite. Genial. I don't think he's genuinely that friendly without any hidden motive or precaution, but he is courteous. He greets Pyke politely and addresses him directly, speaking to him familiarly. During the fight itself, more than once, Rex gives the entire crew the chance to back off and leave. Before the fight, he sat there and warded them off without any damage for a good few minutes. He didn't jump into it willy nilly with the outright intention of hurting them. Which isn't exactly to say the crew did but it is to say he didn't seem gung ho about it either.

In the episode Highway Star, Pyke is as per usual antagonistic towards Rex. Alright, fair. Fine. But Rex, while being a shite, kinda..... Isn't. He could've said some rather cutting or outright hurtful things about Pyke not racing or about him overtaking Pyke's ranking on the Pathway, but he didn't. Not a word about it all things considered. He went about his business as usual, from what we see when Laboosh and Chuckles go and sabotage him. He didn't go out of his way to fuck with Pyke and the crew while they were at the Pathway. He went out shopping for himself at a space strip mall, minding his business for all we see.

Now obviously let's circle around to the Main Thing Here, episodes 13 and 14. The big finishers. The gamechangers.

I obvs can't say for certain of Khan asked Rex to help the crew out or if Rex went of his own volition, but my feeling is a bit of both tbh. He showed up when they were in some Shit to help. Obvs I will forever giggle about Andy's "I Saturn Eats His Son Rex" but given im focussing on in universe and not meta, it's disregarded for the sake of this.

Now the main catch point here that prompted all of this thought in the first place is that when Rex points a gun at Pyke, Pyke's first instinct is to assume that Rex is going to kill him. He genuinely believes with everything in him that Rex, after all that, all the blood and sweat and tears of the fight before and everything before that (including a very nice cigarette left in payment for one freely given), would turn and shoot him with zero hesitation. And accepts that.

Rex, on the other hand, was trying to defend him. He was trying, even after every shitass comment and snide remark and the race sabotage, to save Pyke's life. He was watching and prepared to shoot somebody he knew Pyke cared about in order to save his life. He gave Rett his speeder for that same purpose, something we can reasonably assume is precious to him given that he's had it, or some version of it, about as long as Pyke has had the Sparrow. Something that very clearly would have saved his life, and whatever was salvageable of Khan's life as well since it's unclear what level of dead he was. He could've got out and chose to try and save Pyke instead

And when they make outside, Rex hands over the penultimate piece; the papers he stole from the boss. The very thing that got him into this entire mess in the first place. The reason that he and his mentor figure are going to die on a frigid rock displaced in space.

It was all about Pyke. From the very beginning, to the very end, it was about Pyke and his safety.

The entire time, Pyke saw Rex as someone he disliked. Someone aggravating, a thorn in his side, a threat.

While Rex ricked everything, and in the end gave everything, for Pyke. He loved him, in some way, in some capacity. He saw a danger to Pyke and put himself in a very dangerous position to try and lessen or eliminate that threat from The Boss and who he worked for. He was ready and willing to possibly kill someone Pyke cared about, Laboosh, to save his life.

I. Man I just-

Idk does anybody else just *gestures vaguely at all of it*

[boypussydilf]

dont think about betty on her own thinking about how she gave up so much in her life and so much she wanted to do and so much of her own independent identity to follow simon and do what he wanted to do. oh god dont think about simon telling betty he wants her by his side and she cancels her trip to stay with him and when he spins her around he leaves her standing just one step beneath him. but in the theoretical reality where he goes with her they stay on the same level the entire time. and who knows what would’ve happened. but it didn’t happen and they’ll never get to know. no changing it. betty doesn’t regret anything. they made their own choices. and don’t think about simon having this realization that changes everything way, way too late, with absolutely nothing left to do about it but just. know. and keep going. and don’t think about that being how it ends. they never see each other again. Yeah it’s too late I’m crying so much

[colinwilson11]

The Rise Of CGAS-STING Pathway Market Therapies Will Lead To A Revolution In Cancer Immunotherapy

The CGAS-STING pathway market will grow at the highest pace owing to increasing R&D and growing potential of nucleic-acid sensing pathway modulators in cancer immunotherapy. The innate immune system recognizes nucleic acid species unique to pathogens via cytosolic DNA sensors and mediates type I interferon (IFN) responses that are critical for anti-viral immunity. Of these sensors, the cGAS-STING pathway couples cytosolic DNA sensing to type I IFN induction and downstream transcriptional programs. Once activated, cGAS produces the second messenger cyclic GMP-AMP (cGAMP) which binds and activates stimulator of IFN genes (STING). This signals the activation of downstream IFN regulatory factor 3 (IRF3) and NF-κB, leading to production of type I IFNs and pro-inflammatory cytokines.

The CGAS STING Pathway Market is estimated to be valued at US$ 0.46 Bn in 2024 and is expected to exhibit a CAGR of 25.% over the forecast period 2024-2031.

Growing significance of immunotherapy in cancer treatment and the advantages of targeting the cGAS-STING pathway such as involvement in sensing tumor DNA in the cytoplasm and activation of potent antitumor immunity has augmented the demand of associated drugs and therapies. The success of immunotherapy approaches has led to substantial investment in nucleic acid-sensing pathway modulators by pharmaceutical companies.

Key Takeaways

Key players operating in the cGAS-STING pathway are IFM Therapeutics, Bristol-Myers Squibb, Novartis, AstraZeneca, Merck & Co. Companies are investing heavily in R&D to develop novel therapeutics targeting this pathway. For instance, IFM Therapeutics is developing first-in-class STING agonist focusing on liver and gastrointestinal cancers in phase I/II clinical trial.

The demand for cGAS-STING therapies is increasing rapidly mainly due to growing demand for innovative cancer immunotherapies. According to American Cancer Society, around 1.9 million new cancer cases are diagnosed in the US annually presenting massive market potential. Additionally, improving accessibility of immunotherapy in developing countries will further drive the demand.

Advancements in understanding molecular mechanisms of cGAS-STING pathway activation and development of novel agonist and modulators have expanded therapeutic applications. Ongoing research for developing vaccines and combination therapies with checkpoint inhibitors holds promise to revolutionize cancer treatment through innate immunity activation.

Market Trends

Combination therapies research: There is growing focus on exploring synergies of cGAS-STING agonists with other immunotherapies like checkpoint inhibitors. Ongoing clinical trials evaluating combinations are demonstrating encouraging response rates.

Personalized medicine approach: Efforts are being made to develop biomarkers to predict response and identify patients likely to benefit from cGAS-STING therapies. This personalized approach can improve clinical outcomes.

Geographical expansion: Major players are expanding manufacturing and clinical trials to countries like China and India having huge patient pools. This will boost accessibility and commercialization prospects.

Market Opportunities

First STING agonist approval: IFM Therapeutics' lead molecule will be the first STING agonist examined in registrational trials paving way for first approval in 2026-27.

 Increased adoptability: As clinical evidence demonstrating benefits of cGAS-STING modulation emerges, adoption rate in treatment guidelines and clinical practice is expected to surge exponentially.

New therapeutic areas: Preliminary evidence shows cGAS-STING pathway also plays a role in autoimmune diseases providing scope for therapies in indications beyond oncology.

Impact Of COVID-19 On CGAS STING Pathway Market Growth

The COVID-19 pandemic has profoundly impacted the CGAS STING Pathway Market. During the initial outbreak in early 2020, the market recorded a decline as research activities slowed down and clinical trials faced interruptions due to lockdowns and social distancing norms. However, with shifting focus on immune therapies for tackling novel coronavirus infections, the interest in CGAS STING pathway modulators witnessed rapid growth. Many companies expedited their programs related to IFN activation via cGAS-STING pathway to develop host-directed antiviral therapies against SARS-CoV-2. The pandemic highlighted the need for developing strategies to strengthen innate immune responses via cGAS-STING pathway modulation. While clinical studies faced delays in 2020, collaborations between industry and research institutes intensified to advance immunotherapies targeting this pathway. Moving forward, the high growth projected for this market is expected to accelerate further on the back of strong ongoing research to evaluate potential of cGAS-STING pathway modulators as adjuvant or monotherapy for COVID-19.

Regional Concentration Of CGAS STING Pathway Market

North America currently dominates the CGAS STING Pathway Market and holds over 40% of the global market share in terms of value. This is due to high immunotherapies R&D spending and strong presence of key market players in the US. Moreover, the region is an early adopter of novel immune mechanisms and immune-oncology approaches. Within North America, the United States represents the most lucrative market owing to significant research funding and growing clinical adoption of STING agonists. On the other hand, Asia Pacific region is projected to witness the fastest growth during the forecast period with a CAGR of over 30%. This impressive growth can be attributed to rising healthcare expenditure, expanding clinical research infrastructure and growing focus of global pharma companies on emerging Asian markets. China and India are expected to spearhead the growth of CGAS STING Pathway Market in Asia Pacific region.

Europe currently represents the second largest regional market for CGAS STING pathway modulators globally. Availability of latest healthcare technologies, sophisticated research infrastructure and presence of major industry players have aided the growth of CGAS STING Pathway Market in Europe. Within the region, Germany, United Kingdom and France together hold around half of the total European market in terms of value. However, Eastern Europe is estimated to depict the fastest gains owing to increasing government spending to strengthen native research capabilities. Moreover, growing collaborations between European and US pharmaceutical firms will further stimulate market growth during the forecast period.

Get more insights on this topic:  https://www.trendingwebwire.com/cgas-sting-pathway-market-is-estimated-to-witness-high-growth-owing-to-advancements-in-precision-cancer-immunotherapies/

Author Bio

Vaagisha brings over three years of expertise as a content editor in the market research domain. Originally a creative writer, she discovered her passion for editing, combining her flair for writing with a meticulous eye for detail. Her ability to craft and refine compelling content makes her an invaluable asset in delivering polished and engaging write-ups. (LinkedIn: https://www.linkedin.com/in/vaagisha-singh-8080b91)

What Are The Key Data Covered In This CGAS STING Pathway Market Report?

:- Market CAGR throughout the predicted period

:- Comprehensive information on the aspects that will drive the CGAS STING Pathway Market's growth between 2024 and 2031.

:- Accurate calculation of the size of the CGAS STING Pathway Market and its contribution to the market, with emphasis on the parent market

:- Realistic forecasts of future trends and changes in consumer behaviour

:- CGAS STING Pathway Market Industry Growth in North America, APAC, Europe, South America, the Middle East, and Africa

:- A complete examination of the market's competitive landscape, as well as extensive information on vendors

:- Detailed examination of the factors that will impede the expansion of CGAS STING Pathway Market vendors

FAQ’s

Q.1 What are the main factors influencing the CGAS STING Pathway Market?

Q.2 Which companies are the major sources in this industry?

Q.3 What are the market’s opportunities, risks, and general structure?

Q.4 Which of the top CGAS STING Pathway Market companies compare in terms of sales, revenue, and prices?

Q.5 Which businesses serve as the CGAS STING Pathway Market’s distributors, traders, and dealers?

Q.6 How are market types and applications and deals, revenue, and value explored?

Q.7 What does a business area’s assessment of agreements, income, and value implicate?

*Note: 1. Source: Coherent Market Insights, Public sources, Desk research 2. We have leveraged AI tools to mine information and compile it

[strategiadvizo]

Unlocking Career Opportunities with "Mastering Indian Tax Planning and Return Filing"

In the evolving landscape of the Indian economy, taxation stands as a pivotal element driving the financial framework of both businesses and individuals. With the government’s dynamic regulatory changes, especially with the introduction of GST, the demand for knowledgeable tax professionals has surged. This presents a significant career opportunity for students and aspiring professionals eager to…

[techdriveplay]

Getting Into Kart Racing

Kart racing is a highly thrilling form of motorsport that serves as the gateway for many aspiring racers into the world of competitive racing. At its core, kart racing involves driving small, open-wheel vehicles known as karts around a track. These machines may look simple at first glance, but they offer an intense racing experience that requires skill, precision, and a deep understanding of…

[reasonsforhope]

"China’s carbon emissions have flatlined over the past six months and there’s now an opportunity for substantial declines over the next decade, analysts say.

The rapid growth in clean energy generation has been sufficient to offset a recent surge in power demand caused by higher air conditioning use amid late-summer heatwaves, and the government’s manufacturing push, according to an analysis by Lauri Myllyvirta of the Centre for Research on Energy and Clean Air (CREA).

China’s carbon emissions fell by 1% in the second quarter of 2024 and were flat in the third quarter, providing another indication that emissions may have already peaked.

This is largely because solar power output was up 44% in the three months to end-September, compared to a year before, while wind power generation grew 24%. In the first nine months of 2024, China installed 161GW of new solar capacity and 39GW of wind, per CREA data.

For emissions to post a decline in 2024 as a whole, there will need to be a 2% reduction in the fourth quarter, Myllyvirta’s calculations show. That’s probable if power demand growth cools as expected and hydro plants perform in line with historical averages, he wrote in a post on X, adding that over the entire summer period, clean energy expansion covered all electricity demand growth.

“If the current downturn in China’s emissions is sustained — with emissions falling in the second quarter and stable in the third quarter — that would open the door to the country beginning to reduce emissions much faster than its current commitments require.

“This would have enormous significance for the global effort to avoid catastrophic climate change, as China’s emissions growth has been the dominant factor pushing global emissions up for the past eight years since the signing of the Paris climate agreement.”

Based on current trends and targets, CREA expects China’s emissions will decline 30% by 2035. The International Energy Agency says emissions will fall 24% by then based only on stated policies, but that could be raised to 45% if the country follows a pathway that’s consistent with its long-term carbon neutrality target.

For the time being, Chinese policymakers are setting relatively unambitious targets, and “it’s vital that future targets reflect ongoing clean energy trends to avoid locking in lower ambitions,” Myllyvirta said."

-via The Progress Playbook, October 29, 2024

[tacgenomics20]

Rna-Seq Revelations: Pathway Analysis As The Genomic Compass

The advent of RNA-Seq technology has ushered in a new era of exploration, unraveling the mysteries encoded within our genes. Scientists delve into the vast sea of RNA data, and Pathway Analysis emerges as a powerful tool in their research. Let's explore a journey through the genomic landscape, where RNA-Seq becomes the compass guiding us through the intricacies of cellular pathways.

Read More :- https://www.myvipon.com/post/865752/Pathway-Analysis-The-Genomic-Compass-amazon-coupons

[electronalytics]

Biomass Refining Market Overview, Demand, Key Players and Regional Outlook Study 2017 – 2032

Overview:

The Biomass Refining Market refers to the market for converting biomass feedstock into value-added products through various refining processes. Biomass refers to organic materials derived from plants and agricultural residues, which can be used as a renewable and sustainable source of energy and chemical feedstock. Biomass refining involves the conversion of biomass into biofuels, biochemicals, bioplastics, and other valuable products. The Global Biorefinery Market is estimated to reach over USD 336.39 billion by 2031, exhibiting a CAGR of 9.06% during the forecast period. Here is an overview, key trends, key points, and demand factors related to the Biomass Refining Market:

Key Trends:

•             Shift towards Renewable Energy: The increasing focus on reducing greenhouse gas emissions and dependence on fossil fuels has propelled the demand for renewable energy sources. Biomass refining plays a vital role in the production of biofuels, such as bioethanol and biodiesel, which can replace fossil fuels in transportation and power generation.

•             Circular Economy and Waste Valorization: Biomass refining enables the valorization of organic waste streams and by-products from agricultural, forestry, and food processing industries. It contributes to the circular economy by converting waste materials into valuable products, reducing waste generation and promoting sustainable resource utilization.

•             Advanced Conversion Technologies: Advancements in biomass refining technologies, such as pyrolysis, gasification, and enzymatic hydrolysis, have improved the efficiency and scalability of biomass conversion processes. These technologies offer opportunities for the production of advanced biofuels and high-value biochemicals from diverse biomass feedstocks.

•             Biorefineries and Integrated Value Chains: Biomass refining often takes place in biorefineries, which are facilities that integrate multiple conversion processes to maximize the production of various products from biomass. Integrated value chains, where different industries collaborate to optimize biomass utilization, are emerging to leverage the potential of biomass refining across multiple sectors.

•             Policy Support and Incentives: Government policies and incentives promoting renewable energy, sustainable development, and decarbonization efforts are driving the demand for biomass refining. Supportive regulations, financial incentives, and research and development initiatives are encouraging investments in biomass refining technologies and infrastructure.

Key Points and Demand Factors:

•             Bioenergy Demand: The demand for bioenergy as a renewable alternative to fossil fuels in transportation and power generation is a significant driver for biomass refining. Biofuels derived from biomass, such as bioethanol and biodiesel, are sought after to meet renewable energy targets and reduce carbon emissions.

•             Sustainability and Environmental Concerns: Biomass refining offers a more sustainable and environmentally friendly alternative to traditional fossil fuel-based industries. The utilization of biomass feedstocks helps reduce greenhouse gas emissions, promote waste valorization, and minimize the environmental impact of energy and chemical production.

•             Renewable Chemicals and Materials: The demand for renewable chemicals and materials, such as bioplastics, bio-based polymers, and biochemicals, is growing. Biomass refining enables the production of these sustainable alternatives, driven by consumer preferences for eco-friendly products and the need to reduce reliance on petrochemicals.

•             Feedstock Availability: The availability and accessibility of biomass feedstocks, including agricultural residues, dedicated energy crops, and forestry residues, influence the demand for biomass refining. Regional biomass availability and supply chain logistics play a crucial role in determining the viability and competitiveness of biomass refining operations.

•             Technological Advancements and Cost Competitiveness: Continuous technological advancements in biomass refining processes, such as improved conversion efficiency, scalability, and cost reduction, are key factors driving market demand. The ability to produce biofuels and biochemicals at competitive prices compared to fossil fuel alternatives is essential for market growth and adoption.

We recommend referring our Stringent datalytics firm, industry publications, and websites that specialize in providing market reports. These sources often offer comprehensive analysis, market trends, growth forecasts, competitive landscape, and other valuable insights into this market.

By visiting our website or contacting us directly, you can explore the availability of specific reports related to this market. These reports often require a purchase or subscription, but we provide comprehensive and in-depth information that can be valuable for businesses, investors, and individuals interested in this market.

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Market Segmentations:

Global Trailer Substation Market: By Company

• Hitachi

• Siemens

• Matelec

• Efacec

• EATON

• CG

• GE

• EKOS Group

• WEG

• Delta Star

• Meidensha Corporation

• AZZ

• Ampcontrol Pty Ltd.

• Tadeo Czerweny S.A.

• Tgood

• VRT

• Powell Industries

• Jacobsen Elektro

• Elgin Power Solutions

• Aktif Group

Global Trailer Substation Market: By Type

• HV Trailer Substation

• LV/MV Trailer Substation

Global Trailer Substation Market: By Application

• Energy

• Infrastructure

• Industrial

• Others

Global Trailer Substation Market: Regional Analysis

All the regional segmentation has been studied based on recent and future trends, and the market is forecasted throughout the prediction period. The countries covered in the regional analysis of the Global Trailer Substation market report are U.S., Canada, and Mexico in North America, Germany, France, U.K., Russia, Italy, Spain, Turkey, Netherlands, Switzerland, Belgium, and Rest of Europe in Europe, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, China, Japan, India, South Korea, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), and Argentina, Brazil, and Rest of South America as part of South America.

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[yourstardarling]

Lilith Analysis

(Lady Lilith, by Dante Gabriel Rossetti)

In my perspective, Lilith symbolizes the female intuition which is often vilified in our patriarchal society. She questions the status quo, defying societal norms and forges her own path for how she lives her life. In some interpretations, Lilith is depicted as the serpent in the garden, tempting Eve with the apple as revenge for her expulsion after refusing to submit to Adam. Targeting Eve instead of Adam, shows how Lilith understands the curious nature within women to want to know more and what ifs. It is the same curiosity that made Pandora open the box releasing malicious spirits into the world.

The energy of Lilith is a vengeful one as she sought revenge against God for her banishment out of the garden. In her expulsion, she was stated to steal babies and harm innocent lives, unsympathetic to anyone in her way. So within our charts, Lilith shows where we've experienced profound shame and societal rejection. It is where we are often demonized for refusing to yield to others' expectations. If we don't heal this pain it often becomes a form of self-destruction, fueling a need to gain revenge, harming anyone in our path. This part of our chart is usually suppressed, relegated to the shadows, but integration of this energy is crucial. Mainly because keeping our shame underneath the surface will often cause self-sabotage within the house Lillith is in. Finding the underlying root of the problem will often lead to reclaiming of your power, making Lilith be an energy of magnetization and authority. Neglection will only exacerbate internal conflict.

Lilith in the 1st:In the first house, these individuals are the walking embodiments of Lilith. They are often faced with deep-seated feelings of shame regarding their sexuality and physical appearance. Many have endured the pain of bullying in their youth, which has made them feel shunned out from society. This shame becomes a heavy burden that feels as if it is a part of them, complicating efforts to express their true self openly. Consequently, a portion of their identity remains veiled, guarded against potential judgment or rejection from others. Yet, beneath this veil within their unconscious, lies a potent magnetism. A profound sense of sexuality that others find rather attractive or unsettling. They find themselves both desired and feared. But honestly like Britney said it’s because, "All of the boys and all of the girls want to if you seek Amy." Lilith's influence in this house encourages independence and self-assertion. It teaches the importance of standing firm in the face of societal pressures and refusing to be demonized for your own authenticity. However, yielding to criticism and seeking external validation risks facing internal conflicts. A constant battle against yourself. That is why confronting the shadow aspects of one's personality should be practiced, as it offers a pathway to self-discovery and empowerment. When you are able to show resilience and unwavering faith in yourself, you're able to garner admiration and respect from those around you. The ability to transmute pain into productive actions serves as a magnetic force, attracting allies and opportunities alike. Learning to embrace your inner sexual energy is imperative, as it is something that cannot be suppressed. Unfortunately, this embracement may invite unwanted attention, leaving you vulnerable to exploitation and trauma. Overall, the role of Lilith in the first house is one of self-acceptance and defiance against societal norms. It's a journey marked by challenges, but also by profound personal growth and authenticity.

Lilith in the 2nd: In the house of personal gains, Lilith has felt great shame surrounding her personal values. Individuals with this placement have a hard time surrounding their self worth and physical assets. Possessive tendencies lie beneath the surface, as a consequence from being betrayed in the past. People may have taken advantage of them for their material value and stolen from them. Financial wounds run deep making them unable to properly trust themselves with money. Might find themselves in cycles of reckless spending, prioritizing instant gratification over long term investments. The types go on a shopping spree and then feel guilty for indulging materialistically.These people can either be overindulgent or extremely picky when it comes to what they spend. There is an inherent value of pleasure and spending resources on things that make you feel good.The sign Lilith is in will give you an idea on what you unwarily spend money on and guide your financial decisions. Implementing a budget plan can be very beneficial in uncovering and healing shame surrounding your spending habits. It will help you regulate your spending. Underlying shadow challenges when it comes to self worth is another aspect of this placement. Leading to having doubts about deservingness and attaining success. Lilith in the 2nd, prompts a reevaluation of your values. Rather than being overly picky, you're encouraged to be intentional in your pursuits. Learn to align your investments with your deepest values and aspirations. Family dynamics may also contribute to your relationship with money, with the possibility of past generations engaging in questionable financial practices. Additionally, Lilith's immature aspects may tempt individuals to resort to unethical means of acquiring wealth, such as engaging in sex work or participating in illicit activities. However, succumbing to these temptations risks exploiting others and ultimately perpetuating cycles of harm. In navigating the influence of Lilith in the 2nd house, you are urged to exercise caution and integrity in financial dealings. By confronting shadows and cultivating a sense of self-worth, they can transcend shame and reclaim power over their financial well-being.

Lilith in the 3rd: When Lilith is in the third house of youth and mental stimulation, these individuals have deep shame within their speech and communication. Oftentimes they were demonized as a child, facing constant scrutiny about their childish behavior. Parental guardians made them seem like they were to blame for the smallest issues that occurred. In school they may have felt shunned out from their peers, becoming the target of bullying and ridicule. This ridicule can even come from their teachers that overly criticized them for not being the perfect student, leading them to feel like they were a bad kid. Might indicate having a speech impediment, having a hard time communicating how you feel and issues surrounding being able to read. Your intelligence was significantly downplayed from the earlier years of school which made you believe you were dumb. For this reason, you may prefer being quiet and only speaking when you are needed to, often avoiding starting conversation. To others you may seem standoffish when you speak, but instead it can be anxiety to say what you really want because of public reaction. This Lilith wound is one centered around your inner child and taking back power over your mind. Intrusive thoughts of feeling less than can often be an underlying trigger, but you must recognize that these voices in your head are not your own. It is programming from the ridicule you received as a kid. Mindfulness and meditation practices can help regulate the outside input that comes in your head. You're a very intellectually capable individual that often understands knowledge about topics considered unconventional by society. Don’t be ashamed of what you know and use it to teach other people information you are passionate about.

Lilith in the 4th: Within the house of home and heritage, Lilith has wrested with feeling of shame for her family background. These individuals can often grow up feeling sexually repressed by their family. Criticism for what they were and being called a slut for wanting to express themselves. This placement reminds me of Meg from Family Guy, and how she is consistently made the butt of all ridicule by her family. As you went through puberty, you could've felt uncomfortable being objectified by family members. Some could've faced even faced exploitation by their own family. There is a strange focus on purity within the household and committing towards conservative ideals of presenting yourself. From their point of view, you may be seen as someone who is promiscuous and disobeying traditional values. You might find it hard to feel at home within yourself because of these past afflictions. This can even lead to you feeling ashamed about your emotional responses, often viewing them as evil instead of necessary feelings. Aside from sexuality, this Lilith placement also indicates having shame regarding your origin. There might have been concealed truths about your birth, unraveling as you mature. Might have felt like your family were strangers and you did not belong with them. Issues with the mother figure can be highlighted by this placement. You don't get along well and could feel a sense of cruelty from her. A shadow side to you is kept veiled from your family, which makes you feel like an outsider by them. You may have a reputation of being the rebellious cousin. They may harbor outdated ideologies such as racism, homophobia and xenophobia, that makes you more ashamed of them. The home you grew up in may have been the cause of this shame too, because of its design or infestation issues. Overall, stepping away from your family's point of view of the world is a big factor with this Lilith placement. You cannot allow their lives to dictate who you are meant to be. Learning to nurture yourself and finding your own community is an essential part of your journey. As time pass, you may discover yourself becoming a space for other people to confide in about their personal issues. A testament to Lilith making a home for herself outside the boundaries of Eden.

Lilith in the 5th: In the fifth house, individuals have grappled with profound shame surrounding the way they experience pleasure within their lives. Their childhood may have been faced with restrictions on the ways they could have fun, such as engaging in hobbies solely to appease their parents rather than for personal enjoyment. Activities you found enjoyment in, felt like you needed to keep hidden away from other people in order to not get ridiculed. There are plenty of hobbies you enjoy that others will find unorthodox to have. For example, going to shooting ranges, participating in drag shows, taking part in the circus or cosplaying your favorite characters. When it comes to your talents, you might face envy from others because they want the attributes that you have. May face hate in your extracurricular activities and being outcasted by team members. In your own eyes, your often unsure about your talents and feel like you're not good enough in your practice. Additionally, there is also shame regarding sexual pleasure. You might find it fun to explore, but some experiences make it unsettling for you to enjoy. There may be a need to keep your sex life a secret from other people. However, sex positivity can be a notable aspect of this placement though, not having much conservative notions in your sexual experiences. When it comes to children, you might feel some shame for not wanting to have kids and face scrutiny from others for this stance. You can even feel like you hate the thought of children and not wanting them around you. If you do end up having kids, they can exhibit Lilith quality traits of rebellion and unorthodox behavior. There is definitely a shadow side to how you gain pleasure with this placement, indulging in self destructive behaviors and selling yourself away for fun. You must learn to tame that primal urge within you when you are having a great time. Especially as this can lead to addictions to pleasure, such as having a gambling, drug abuse and being overly sexual. Learn to set boundaries when you're having fun.

Lilith In the 6th: In the house of service, Lilith plays a commanding role within her work space. This placement reminds me of The Devil wears Prada, where Miranda was seen as a formidable figure by her colleagues. Similarly, coworkers may harbor similar feelings toward you, casting you as assertive & harsh. You may face a lot of scrutiny in the workplace and could even work in an environment where there's a prevalence of discrimination. Workplace harassment can occur here as well, oftentimes facing oversexualization. Navigating and accepting your shadow persona in the workplace becomes essential. As long as you come there to do your job, that’s all that matters. Just try not to lash out at your colleagues because of misconception and other issues. There may be a big rumor that you are lazy for not doing as much as everyone else. However, you're the type of person that only comes and does the work that is necessary, not overworking themselves as everyone else. On the flip side, you can be hyper focused on work and do a lot more in your day that others don’t really see. This can take a toll on your health and work stress can be a big indication of this placement. Speaking of health, you might have a terrible relationship with health officials. Health experts in the past might have treated you poorly and even faced a misdiagnosis. Your relationship with health overall is something you can feel intense emotions around. A health condition could make you feel like you don’t have the same capabilities as other people. Might struggle with digestion and eating food to nourish yourself. There is a lot of necessary shadow work to uncover within your habits and daily routines with this placement. Learn to not be so hard on yourself, making time to properly maintain your physical needs.Health is wealth after all.

Lilith In the 7th: When Lilith lies in the house of partnerships, there is often shame surrounding the close connections these people have. They often easily attract people with Lilith energy in their lives, such as rebellion, ostracization and outcasts. You're often able to see the version of others that they keep hidden underneath. For some reason, people can feel like they can trust you with their problems and you make space to not judge them. Something about you just allows people to feel easily able to open up their shame to you. It might be because there is a part of you that has felt the same shame of being shunned out by other people. In your love life, there could be a tendency to feel outcasted by your partners which leads to having a warped perception of yourself. Partners often can make you feel like you are too much and incapable of being loved. May find it hard to feel their needs being met in their personal relationships. Here lilith indicates issues of being taken advantage of by other people and personal power being exploited. Aggressive aspects can also show facing abuse, which can make these individuals pretty guarded when meeting others. You could feel the need to be in control and have a dominant role in your love life. However, self-destructive tendencies may spur from not getting what you want out of a partner and lead you sabotaging your connections. You can often pursue relationships you know are unhealthy for you. There’s a tendency to want people that bring out an unhinged version of yourself, becoming a whole different person with a partner. Shadow work needs to be done as to why you chase these toxic connections, which sometimes is rooted from the way you viewed the partnership of your parents.

Lilith in the 8th: In the house of death and loss, Lilith is put to face the extremes. Each time they are in a transitional phase in their lives, they get kicked out of their paradise. These individuals understand the darker sides of life and are somewhat good at navigating their shadow. Shadow side can often take things to the extreme when they are out of control. Really good at understanding the taboo and being okay with things that are scarier for other people. A necessary need to make peace with inner demons and resolving past psychological conflicts. While they are able to easily exude a seductive persona, sex can be a harsh topic for them to feel comfortable with. Losing their virginity might have been a monumental experience that shifted the way they act in their lives. There is a need to work on resolving issues with sex and not being afraid of it . Also, you might be into some fetishes that you feel the need to keep hidden from other people. Hiding is a big coping mechanism for them, whenever they feel like the world rejects them, they bury themselves down in shadows to not be seen. A distinct relationship with death, some hold huge guilt for being unphased by death, while others worry about their own deaths. If a family member had died, you might feel guilty for not being sad or crying at the funeral. These people can mourn their innocence a lot, thinking of a time they were untouched by the world around them. During transitional phases of your life, you could be vilified and demonized for acting differently. Might have had a dark aesthetic or emo phase during your teen years. Change can be a scary thing for you and you could harbor strong resistance towards new possibilities. This mainly comes from the scrutiny you’ve felt by other people. Learn to embrace the taboo and understand change will only allow you to reclaim your power.

Lilith in the 9th: These individuals hold a complex relationship with religion and belief systems. Growing up, they likely experienced a religious environment that instilled fear and submission to authority. It's possible they had overly religious parents who prioritized adherence to faith, rather than showing genuine love and understanding for their children. As you mature, there's a tendency to reject traditional systems of beliefs for more esoteric philosophies, helping you find empowerment through alternative spiritual paths. Although shifting your beliefs will allow you to have a sense of freedom, remnants of past religious trauma still linger in your mind. Guilt for what you believe in is a big focus for this placement. They often find themselves at odds with mainstream perspectives, feeling a sense of alienation and struggling to fit in. There's a tendency to doubt their intelligence and the information they know. This struggle extends to academic pursuits as well, where they may feel out of place and struggle to connect with their peers. Moving away from their area of upbringing can be liberating, allowing them to explore their shadow aspects and embrace their darker side through travel and adventure. In doing so, they may discover a newfound magnetism and allure, attracting others to their path towards self-discovery.

Lilith in the 10th: In the house of public career, Lilith exerts a strong influence on one's outward image and persona. When in public settings, you often see people being easily magnetized towards you. If Lilith is conjunct the Midheaven (MC), it can signify experiences of unwanted attention, including catcalling. There's a deep-seated fear of being seen, stemming from the difference between your public persona and true self-image. Overexposure to the public eye can lead to discomfort, particularly in career fields where others seem to dominate or overshadow you. There is a natural ability to exude sensuality that others find intriguing. They may develop a reputation for sensuality and allure, which can intimidate others, particularly men, due to the inherent power they radiate. Despite the fantasization, they may resent the objectification and sexualization. In professional settings their bosses may even attempt to take advantage of them. This placement can also indicate stage fright and social anxiety, causing them to prefer the sidelines rather than the spotlight. An unbalanced version of this placement would be sabotaging yourself when it comes to your career. Promoting bad behavior so that you can gain the upper advantage in situations. It's crucial for them to be vigilant against exploitation by authority figures and to properly navigate professional relationships and contracts. Despite potential misconceptions about their character, individuals with this placement must embrace their authenticity and prioritize their own career aspirations over societal expectations. Your that b*tch for real, and you cannot allow the public opinion of you to dictate who you are. Also, Lilith in the 10th house may signify a challenging relationship with their father, involving absence, mistreatment, or attempts at control. This further fuels aspirations to become a successful person, in order to prove their farther wrong. Embracing their power and authenticity is important for success and fulfillment in the professional world.

Lilith in the 11th: Friendships are never easy with Lilith in the 11th. Despite outward display of support, these individuals frequently encounter betrayal from those they consider close allies, discovering that supposed friends harbor secret animosity and ulterior motives towards them. Friends could make jokes about insecurities you have, while accusing you of being soft for finding offence. Your secrets are not the safest within your social networks, they are like blind items ready to spill all the tea about your personal life. This atmosphere of distrust can lead to a cautious approach to forming friendships, resulting in a preference for family and romantic relationships over the unpredictability of friendships. Despite these challenges, individuals with this placement often gravitate towards unconventional or marginalized groups of people. Finding companionship in the outcasts who defy societal norms. They may become strong advocates for the rights and liberation of marginalized groups, focusing on the need for women's rights and the empowerment of societal underdogs. So while friendships may be met with much difficulty, these individuals create meaningful connections with fellow non-conformists in society. Finding solidarity in their shared struggles, leading to finding community outside of Eden.

Lilith in the 12th: Individuals with Lilith in the 12th house tend to keep Lilith's energy to the depths of their subconscious mind. They are often unaware of its magnetic, rebellious, and sexually charged nature. May doubt their own sexuality and seductive capabilities, feeling overshadowed by others charm. However, when in solitude, Lilith emerges to confront them about their inner shadows and demons. This often leads to solitary battles with their deepest fears and insecurities. Sleep issues are common with this placement, as they may struggle to maintain a stable sleep routine. May prefer the quiet solitude of the night for introspection and self-discovery. In their dreams, they often confront scenarios designed to evoke feelings of inadequacy and shame, forcing them to confront their inner vulnerabilities. They can be drawn towards dream working, meditation, shifting and exploring unique ways to access their subconscious mind. By using the arts, they can transmute fears and underlying issues in their mind to a reservoir of creativity. You can often see their shadow portrayed boldly in their art. Also, these individuals are often empathetic and hold nonjudgmental view towards the shadows of other people. Overall, through uncovering their darkness, Lilith in the 12th house can lead to spiritual growth and artistic development when integrated unapologetically.

____

Remember to look at the aspects to Lilith in your chart. Since it is an astrological point & asteroid, it doesn't hold as much significance compared to the planets. So aspects allow you to know how much of this energy can be brought up to the surface. Also, this reading is for all versions of Lilith in the chart.

-your Star Darling

(Portrait of Simonetta Vespucci, by Piero Di Cosimo)

[wosospacegirl]

loved the latest alexia fic haha

i had an idea for us stem girlies (not wanting to study virology btw, so fkn real)

i was thinking a kika fic where readers a bio/stem student & is trying to teach kika something & likewise kika (and the rest of the younger barça girls) tries to teach r football

Summary: Y/N’s been buried in virus replication pathways for hours. Kika’s had enough.

A/N: for the STEM girls who haven’t seen the sun in 3 business days and need a footballer girlfriend to drag them outside - Everything written here was taken from my own notes...I hope they are right, or else it means I failed my own exam.

..

Y/n had been studying for what felt like seven years straight. 

Realistically, it had only been four hours, but time blurred somewhere between drawing replication cycles and muttering the difference between RNA-dependent RNA polymerase and reverse transcriptase.

Kika had been patient. She really had. She brought her water, kissed her temple, and even sat silently nearby, scrolling through TikTok while Y/n ranted about capsids and envelope proteins. 

But now it was too much.

“...and that’s why enveloped viruses are more susceptible to disinfectants,” Y/n concluded, still scribbling away. “You would’ve thought that the envelope would make them more resistant, right?”

There was a beat of silence.

“You realise we were just talking about lunch?” Kika said.

Y/n blinked. “Were we?”

“You brought up protein bars, and then somehow transitioned into protein coats. Again. That’s like the third time.”

“Okay, but it’s actually a really–”

“No.”

Kika stood up with the kind of quiet menace only a very tired girlfriend could summon.

“You need to get out of this apartment.”

“I’m busy! I have an exam, Francisca.”

“You need to touch some grass.”

Y/n gasped, clutching her notes to her chest. 

“You sound like my mom.. Are you okay? Did a neurodegenerative virus get to your brain?” Y/n  squinted her eyes, talking in a very mysterious and suspicious voice. “It could be rabies.”

Kika raised an eyebrow. “Por favor, put on some gym clothes.”

“No.”

“You’re coming with me to the training ground.”

“I’m not playing football.”

“You are, just a bit. You’re going to run, breathe some fresh air. Maybe learn how to use your legs again.”

Y/n narrowed her eyes. “I feel like you want to sabotage my academic life.”

Kika deadpanned, “I just want to have a normal conversation with my girlfriend again.”

Half an hour later, Y/n was in mismatched gym clothes, standing awkwardly on the sidelines of the Barça training pitch while Kika passed her a ball.

“Okay,” Kika said. “Basics. Pass it back.”

Y/n kicked it directly into Kika’s shin.

Kika didn’t even flinch. “Right. That was bad.”

“Yeah, well,” Y/n muttered. “I use my brain, not my feet.”

“You used your foot just now,” Kika deadpanned. “You’re just not good at keeping control of it.”

Before Y/n could come up with a scathing reply involving cortical motor neurons, a trio of voices interrupted from behind her.

“Hi amiga,” Jana grinned, jogged up with Pina and Vicky flanking her. “That pass was criminal.”

“Terrible,” Vicky added.

Pina nodded solemnly. “You’re bad, bad.”

Y/n crossed her arms. “Wow, thank you. So much support.”

Kika smirked from the sidelines.

“She made me come here,” Y/n gestured vaguely toward her girlfriend, “because apparently I’m ‘studying too much’ and need to ‘go outside like a normal person.’”

The girls blinked.

“What are you studying?” Jana asked.

Y/n brightened instantly, like a switch flipped. 

“Oh! I'm doing an exam on virus replication pathways, and it’s super interesting because…wait–okay, so you know HIV, right?”

All three nodded slowly, unsure where this was going.

“Well, it’s a retrovirus, which means it uses reverse transcriptase to turn its RNA into DNA inside the host cell. And that DNA actually integrates into the host’s genome and–wait, let me draw it.”

Somehow, within ten minutes, they’d migrated off the pitch and into the tactical analysis centre. 

A whiteboard was pulled over. Y/n commandeered a marker, drawing the double-stranded DNA meticulously.

“This is the viral envelope, this is the capsid, oh, and DpRd-RT is like–the main enzyme you have to remember, alright? So now we have a full DNA–”

Pina was blinking rapidly.

Vicky was furrowing her brows like she was trying to understand it, really trying.

Jana had started taking notes on her phone.

Kika walked in fifteen minutes later, looking for her girlfriend.

“Amor,” Kika said slowly, “why is my team being held hostage by you and– ai meu Deus…is that a virus?”

Y/n turned around, completely unfazed. “I’m teaching them how HIV uses the host's RNA polymerase II to transcribe proviral DNA.”

Kika stared. “...This started with a bad pass.”

“And now it’s a public health seminar!” Y/n grinned. “Honestly? You're welcome.”

[sunskisser]

oh my gosh! I am in love! pleaseee continue this

https://www.tumblr.com/saturnitystar/758532956071624704/chocolate-coated-hearts-rl?source=share

yesss i love barista!remus too much not to continue <3 !! i got so carried away and this was way longer than i expected it to be haha

chocolate-coated hearts | r.l. (part 2)

୨ৎ series masterlist

barista!remus x shy!reader

tw: fluff, use of y/n

The rain patters down mercilessly, the tip-tap sound from where it’s hitting your file awfully loud. You break into a slight jog, holding the black file above your head as if it would offer some sort of protection against the downpour.

You were on the way back from the university, and had conveniently ignored your roommate’s reminders to bring an umbrella earlier that morning, because oh, are you sure you checked the forecast for the right day? and it hasn’t rained in weeks – why the hell would it rain today? Unfortunately, it did rain today.

The dampness soaked through your shoes as you moved, splashing upwards to wet your pants. You let out an exasperated sigh and lift your head, eyes darting around to seek shelter until the rain subsided.

In your peripheral vision, you could see a library – but that was way too chilly, given the way you were trembling. There was a bar, but… that was where your weird neighbour, Carl, went every evening. And you were in absolutely no mood to entertain his rambling. You wrap your arms around yourself, shivering as you trot a little further in an attempt to find a decent place. Wetness was seeping into your clothes, igniting a chill throughout your entire body.

As the seconds ticked by, you felt the frustration building up. Everything was just going so wrong today. Your lecturer had returned your analysis of Pride and Prejudice, and you had done so badly that it had to be redone. Plus, you were supposed to go out with Madison for lunch, but she had fallen horribly sick. And now, the torrential rain seemed to be mocking you – adding insult to injury.

The warm orange lighting of a sign came into view, and you squint your eyes to make out the words. Rubbing water off your face, you realise that the sign said Beanie’s. Well, it was a cafe – that was good enough. As you veered off the pathway to the right, you could smell freshly-baked cookies and coffee from the place. It better be warm inside, you thought. One more screw-up, and you genuinely believed you would burst.

You come to a stop outside the cafe, taking laboured gasps of air to catch your breath. You shake the water off your file and push the door open, stepping inside.

Fortunately, it was warm inside – you could feel the hot air blowing onto your skin immediately, drying your clothes from inside out. But to your misfortune, the heat seemed to be spreading to your face as well when you caught sight of the person behind the counter.

It had completely slipped your mind. But now it was all coming back to you, staring at his chiselled arms as he placed a plate of bagels on a tray. Your incident a few weeks ago, when you’d embarrassingly frozen on the spot and let the hot barista pick your donuts for you.

That had weighed on your mind for days, the way you had humiliated yourself in front of possibly the most angelic person on earth, and how said angel had treated you as though you were some kind of delicate flower.

You glance back out at the rain, drawing your lip in between your teeth as you contemplated your options. Either you went back out there, or you moved forward and ordered from Mr. Super Hot Barista. And you were definitely not going back into the rain.

Sucking in a deep breath, you brushed your soaked hair out of your face and wiped your hands on your sweatshirt. You shake off as much water as possible before walking towards the counter, feeling shivers run down your spine – from the cold or from shyness, you weren’t sure.

“Hi.” It comes out unnecessarily loudly, and you cringe. You actively try not to ogle at him, and your eyes fall on the tag on his shirt. Remus, it said. For fuck’s sake, even his name was pretty.

Mr. Super Hot Barista – Remus – looked up from the cookies he was boxing, his hazel eyes meeting yours. You could have sworn something like recognition flashed in his gaze. “Hey,” he smiled easily.

It was happening again, and you hated it. You felt your throat start to go dry as you held his gaze, and his smile slowly widened. You swallowed nervously, the quick drip, drip of water from your hair mirroring how fast your heart was beating. He very well knew the effect he was having on you, and was taking full advantage of it.

“So,” Remus started, “What would you like to order, sweetness?”

You thought you were going to pass out from the sheer amount of endearment in the nickname, eyes widening and cheeks turning pink. But you were a strong, independent young woman. And you were not going to let some random barista knock you off your feet.

“One small cappuccino, please,” you squeak, horrified at how small your voice was.

“Right,” he ducked his head to key it into the register, and you resist the urge to reach out and brush your fingers through his gorgeous curls. “And would you like any chocolate donuts with that?”

You swore your stomach flipped upside down at the comment – he remembered your little situation. Your hands come up to cover your reddening cheeks as you involuntarily let out an embarrassed groan.

The sound of his soft chuckle only exacerbates the sensation of your heart bobbing up and down in your chest. “Sorry, sorry – just messing with you.”

You let out a strangled sort of noise, still unwilling to look up and let him see just how flushed you probably were. When you press your face further into your palms, his voice softens. “Hey, I’m not trying to put you on the spot, I swear. I’m sorry.”

The slight tinge of guilt in his voice makes you look up immediately as you drop your hands to your sides. You see him standing in front of the coffee machine, preparing your cappuccino. “No, no. You’re not putting me on the spot, I’m just –” you sputter out, letting out a nervous chortle.

“God, you’re really embarrassed, aren’t you?” he breathes out in quiet laughter. “Calm down, pretty girl. I promise I won’t bite.” That majorly sucks, you thought. You envisioned how his lips would look biting into a cream puff, cursing yourself for even thinking of it a moment later.

“Okay,” you mumble, flipping your slightly less damp hair over your shoulder. And the next thing you utter, you don’t even think about it before saying it. “Don’t call me pretty girl.”

You immediately slap a hand to your mouth, eyes widening in shock at your own tongue. Literature students, and the yappers they are, Madison had once complained. Now you knew just how right she was.

Remus let out an amused snort, his lips curving upwards in a grin. “Okay, sorry, sweetness.”

“Don’t call me that either.”

“Someone’s picky,” he muttered, the smile still on his face as he pressed a lid onto the cup of coffee before pushing it towards you. “What can I call you, then?”

“Y/n,” you mumble, praying that your delight at having been asked your name was not showing on your face.

“Y/n,” he lets it roll around on his tongue, a sweet smile playing on his lips. He scribbles something onto your cup. “That’s a nice name.”

“You too,” you say without thinking, glancing downwards to pull money out the pocket of your pants. You look up to find him eyeing you with his eyebrow arched. A giggle escapes you as you point at his nametag. “Remus, right?”

He looks down at his shirt and chuckles, realisation lighting up his face. “Yeah, my name’s Remus.”

Remus glances back up as you drop the money into his hand. And you’re very careful not to let your fingers brush against his palm this time.

His smile was soft and sunny, making it feel like it had never even rained in the first place. “Bye.”

“Bye,” you echo, your heart fluttering in your chest as you offer him a smile. You turn around to find a table, and just then realise that the cafe was as crowded as it was the last time you were here, if not more.

You purse your lips worriedly. It was still storming outside, and you really needed to get started on your failed analysis and your newly assigned one –

“Y/n!”

You swivel back around to find Remus grinning at you. “You can sit here,” he gestures at the bar stools in front of the platform, which were unoccupied. “I get lonely anyway. It’ll be nice to have some fun company.”

“Oh,” you murmur, an unignorable sense of relief settling over you. “Okay, thanks.” You make your way over, setting your coffee and tote bag down on the platform before hauling yourself up onto the stool.

As he picks up donuts and packs them into boxes, you pull out your book and a stack of foolscap. Remus glances up at the sound, his face immediately lighting up. “M.L. Rio?”

You nod. If We Were Villains was the next book you were assigned to work on.

“That was a good book,” he says casually as he begins to work again. “Why, are you annotating it or something?”

You try not to beam. He reads, your brain was screaming at you. He reads and he has excellent fucking taste. Could he possibly be more perfect?

“Not just annotating,” you reply, a pleased lilt to your voice. “Analysing, for a project. Oh – I forgot to mention, I’m majoring in literature.”

“Literature, huh?” he grins as he sets his tongs down, and he looks almost bemused. “Interesting.”

You pull out a pen and begin to write, the smile never fading from your face. He lets you work in silence, the only sound being the metallic clinking of tongs as he packs pastries into bags and boxes.

“Hot take,” he says suddenly, a couple minutes later. You look up, surprised. “I don’t believe James was some sort of tragic hero, as people make him out to be. I think he was the villain.”

“No.”

“Yes,” he snorts, and a laugh bubbles out of you. “That’s a ridiculous opinion.”

Remus rolls his eyes. “As a literature student, I think you need to be more open-minded.”

“The title is ‘If We Were Villains’, not ‘I Am The Villain’!” you retort indignantly, earning a loud bout of laughter from him. He shakes his head indulgently, continuing to stack boxes. “Great point.”

You can hear the deadpan in his voice, but decide to take it as a victory anyway. Grinning, you get back to your book as a comfortable silence settles over the both of you.

It was hard, but you were trying your hardest not to glance up at him every once in a while. The glowy orange light on the ceiling shone down on him, and you felt your curiosity growing towards the pale scars that decorated his face.

Whenever he caught you staring, you immediately evaded his gaze and took a sip of your coffee, or jotted something onto your paper. You thought you may have seen him trying not to smile a couple of times.

You blink as you glanced at your foolscap, which was full of random squiggly lines and words written in an attempt to make it seem like you were concentrating. But it was absolutely impossible to focus with Remus in front of you.

You furrow your eyebrows disappointedly. It really was important that you finished this up by tonight, and you were obviously not getting any work done here. One look outside told you that, unfortunately, the rain had stopped and the moon had come out.

Remus perked up when he heard the shuffling coming from you. He looked up to see you packing your things. “Leaving so soon?”

“Sorry,” you mutter as you pick up your cup of coffee, almost finished with it. “I’ve got more work to do at home.” The stool screeches as you stand up, slinging your tote bag over your shoulder. You rake your fingers through your hair – you had spent so long in the cafe, it was completely dry now.

He smiles, “Nah, you don’t need to apologise. It was fun talking to you.”

Your heart smiled at that. “Yeah, I had fun too.”

He stays silent for a moment, observing you. Your face starts to feel hot again. “Okay then, I’m gonna go.”

“Hey, wait a minute,” he calls out, causing you to turn back around.

You tilt your head questioningly. “There’s a poetry reading happening here, tomorrow, at 5pm. You like poetry?”

“Yeah,” you reply. “Yeah, I like poetry.”

He nods, the hint of a smile on his lips. “Come round if you’re free. I think you’ll like it.”

It felt like fireworks had begun to explode everywhere within you, from your head to toes and even in those little spaces between your fingers. “Okay,” you murmur. Your heart was tingling with excitement. “I’ll try to make it.”

“Great,” he grins, chucking his hands in his pockets as he leaned against the platform behind him. “Cool, then. See you.”

“See you,” you smile dazedly, pivoting and walking towards the exit with your coffee in hand. Your beam widened as you walked out, strolling back home as you sipped your coffee.

Remus had invited you to a poetry reading. A poetry reading.

Your cheeks ached from how hard you were grinning. You drink the last bit of your cappuccino, going to throw it in a bin on the street. That’s when you caught sight of something scrawled in black ink on the side of the cup.

There was a heart next to your name, and a number below it. Call me, pretty girl, it said in brackets.

You skipped all the way home.

[colinwilson11]

[covid-safer-hotties]

Also presreved on our archive

A history of COVID-19 can double the risk of heart attack, stroke or death according to new research led by Cleveland Clinic and the University of Southern California.

The study found that people with any type of COVID-19 infection were twice as likely to have a major cardiac event, such as heart attack, stroke or even death, for up to three years after diagnosis. The risk was significantly higher for patients hospitalized for COVID-19 and more of a determinant than a previous history of heart disease.

Further genetic analysis also revealed individuals with a blood type other than an O (such as A, B or AB) were twice as likely to experience an adverse cardiovascular event after COVID-19 than those with an O-blood type.

Published in Arteriosclerosis, Thrombosis and Vascular Biology, the researchers used UK Biobank data from 10,005 people who had COVID-19 and 217,730 people who did not get infected between February to December 2020.

"Worldwide over a billion people have already experienced COVID-19. The findings reported are not a small effect in a small subgroup," said co-senior study author Stanley Hazen, M.D., Ph.D., chair of Cardiovascular and Metabolic Sciences in Cleveland Clinic's Lerner Research Institute and co-section head of Preventive Cardiology. "The results included nearly a quarter million people and point to a finding of global health care importance that promises to translate into a rise in cardiovascular disease globally."

Certain genetic variants are already linked to coronary artery disease, heart attack and COVID-19 infection. The researchers completed a genetic analysis to see if any of these known genetic variants contribute to elevated coronary artery disease risk after COVID-19.

None of the known genetic variants were drivers of the enhanced cardiovascular events observed post COVID-19. Instead, the data highlighted an association between elevated risk and blood type.

Previous research has shown that people who have A, B or AB blood types were also more susceptible to contracting COVID-19.

"These findings reveal while it's an upper respiratory tract infection, COVID-19 has a variety of health implications and underscores that we should consider history of prior COVID-19 infection when formulating cardiovascular disease preventive plans and goals," said Dr. Hazen.

"The association uncovered by our research indicates a potential interaction between the virus and the piece of our genetic code that determines blood type and signals the need for further investigation," said Dr. Hazen. "A better understanding of what COVID-19 does at the molecular level may potentially teach us about pathways linked to cardiovascular disease risk."

Hooman Allayee, Ph.D., of USC's Keck School of Medicine, was co-senior author of the paper.

"Our data suggesting that risk of heart attacks and strokes was especially higher among COVID-19 patients with A, B, or AB blood types has significant clinical implications," Dr. Allayee said.

"Given our collective observations and that 60% of the world's population have these non-O blood types, our study raises important questions about whether more aggressive cardiovascular risk reduction efforts should be considered, possibly by taking into consideration an individual's genetic makeup."

The findings show that the long-term risk associated with COVID-19 "continues to pose a significant public health burden" and that further investigation is needed, according to the authors.

More information: COVID-19 is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction with ABO Blood Type, Arteriosclerosis, Thrombosis and Vascular Biology (2024). DOI: 10.1161/ATVBAHA.124.321001

www.ahajournals.org/doi/abs/10.1161/ATVBAHA.124.321001