#Regulatory Test Lab

[tyretestinglabinindia]

Our industry provides the best regulatory testing services for India. IRMRI has a regulatory test facility, ready to ensure your product's quality, click now!

[trivediandassociates]

Why Should You Adhere To Compliance Regulations

We are witnessing an increase in industrial activity with the introduction of modernization. During and after the last decade of the 19th century, there has been an increase in the factories across the globe in the developed and developing countries. Furthermore, employee safety and statutory compliance have become significant in the factories.

What Is the Need for Shop and Establishment Compliance?

Initially, with several processes being performed in the industries, governments across the globe have identified the need for stringent measures in place. Furthermore, it helps in ensuring the welfare and safety of the workers. Additionally, it gave rise to the need for formulating policies and principles which are legally essential in the workspace and factories.

One such regulation is the Gujarat Factory Act 1948. It is a legal necessity which was passed with an aim of strengthening the position of the workforce in any factory. Moreover, with the increase in factories and evolution of the production technology all over the world, it has become important for the government and employers to ensure the safety of the employees. Also, in India, the Factory act 1948 is a major regulatory act related to labour which enforces the shop and establishment compliance. Thus, it ensures a healthy and safe working environment for the employees.

Objectives of the Factories Act, 1948

The major focus of the Gujarat Factory act 1948 is on the regulation of health conditions, working condition, leave eligibility, and safety of the workers. Also, the act covers many special provisions related to young persons, factory employees, and women. The major objectives which focus on the welfare and employee safety via statutory compliance are as follows:

Workplace Safety

The act demands to ensuring the employee’s safety via appropriate fencing of the machinery. Young individuals are not allowed to work in confined locations and dangerous machinery. There should be maintenance holes with proper size which offer enough space for workers to escape during an emergency.

Employees’ Welfare

For ensuring the convenience of the employees, the act needs the factories to offer suitable and proper facilities for drying, washing and storing clothes along with maintenance of these provisions. First-aid kits, space for resting, lunch rooms, restrooms, and crèches are also mandatory.

Read the full blog here: https://trivediassociates.co.in/why-should-you-adhere-to-compliance-regulations/

[science-bastard]

Mad Science Wrapped 2023

Top Experiments

Helping the mice blaze it 420 (extreme success)

Efficacy of laser beams in accelerating bacteria cultures (mixed results)

Using all the spare limbs, organs, torsos, etc you had left over from last year (some success)

Unhornyinator (catastrophic failure)

Weed 2 (nice)

Top Specimens

Mold that flips you off

Borderline incomprehensible mess of various limbs and mouths and eyes and other strange protrusions

Sicknasty penguin-elephant hybrid

Semiorganic robot that loves you

Typical but nevertheless extremely suspicious mouse

Top Areas of Research

Radioactive goo

Unconventional gender affirming surgery (eg fangs)

Laser beams

Having fun with lab rats and mice

Recycling lab waste into newer, sexier experiments

Extras

OSHA regulatory violations: 316

Test subjects tested: 571

Total time in lab: 49,381 minutes

Lab personnel kissed: 1

[thatsonemorbidcorvid]

Since the 1970s, crash test dummies - mechanical surrogates of the human body - have been used to determine car safety.

The technology is used to estimate the effectiveness of seatbelts and safety features in new vehicle designs.

Until now the most commonly used dummy has been based on the average male build and weight.

However, women represent about half of all drivers and are more prone to injury in like-for-like accidents.

The dummy that is sometimes used as a proxy for women is a scaled-down version of the male one, roughly the size of a 12-year-old girl.

At 149cm tall (4ft 8ins) and weighing 48kg (7st 5lb), it represents the smallest 5% of women by the standards of the mid-1970s.

However, a team of Swedish engineers has finally developed the first dummy, or to use the more technical term - seat evaluation tool - designed on the body of the average woman.

Their dummy is 162cm (5ft 3ins) tall and weighs 62kg (9st 7lbs), more representative of the female population.

So why have safety regulators not asked for it before now?

"You can see that this is a bias," said Tjark Kreuzinger, who specialises in the field for Toyota in Europe. "When all the men in the meetings decide, they tend to look to their feet and say 'this is it'.

"I would never say that anybody does it intentionally but it's just the mere fact that it's typically a male decision - and that's why we do not have [average] female dummies."

Several times a day in a lab in the Swedish city of Linköping, road accidents are simulated and the consequences are analysed. The sensors and transducers within the dummy provide potentially lifesaving data, measuring the precise physical forces exerted on each body part in a crash event.

The team record data including velocity of impact, crushing force, bending, torque of the body and braking rates.

They are focused on seeing what happens to the biomechanics of the dummy during low-impact rear collisions.

When a woman is in a car crash she is up to three times more likely to suffer whiplash injuries in rear impacts in comparison with a man, according to US government data. Although whiplash is not usually fatal, it can lead to physical disabilities - some of which can be permanent.

It is these statistics that drive Astrid Linder, the director of traffic safety at the Swedish National Road and Transport Research Institute, who is leading the research in Linköping.

"We know from injury statistics that if we look at low severity impacts females are at higher risk.

"So, in order to ensure that you identify the seats that have the best protection for both parts of the population, we definitely need to have the part of the population at highest risk represented," she told the BBC.

Dr Linder believes her research can help shape the way cars are specified in the future and she stresses the key differences between men and women. Females are shorter and lighter than males, on average, and they have different muscle strengths.

Because of this they physically respond differently in a car crash.

"We have differences in the shape of the torso and the centre of gravity and the outline of our hips and pelvis," she explained.

But Dr Linder will still need regulators to enforce the use of the average female she has developed.

Currently there is no legal requirement for car safety tests for rear impact collisions to be carried out on anything other than the average man.

Although some car companies are already using them in their own safety tests they are not yet used in EU or US regulatory tests.

Engineers are starting to create more diverse dummies, including dummies that represent babies, elderly and overweight people.

The average female dummy in Linköping has a fully flexible spine, which means the team can look at what happens to the whole spine, from the head to the lower back, when a woman is injured.

US company Humanetics is the largest manufacturer of crash test dummies worldwide and is seen as the leading voice when it comes to the precision of the technology.

CEO Christopher O'Connor told the BBC he believes that safety has "advanced significantly over the last 20, 30, 40 years" but it "really hasn't taken into account the differences between a male and a female".

"You can't have the same device to test a man and a woman. We're not going to crack the injuries we are seeing today unless we put sensors there to measure those injuries.

"By measuring those injuries we can then have safer cars with safer airbags, with safer seatbelts, with safer occupant compartments that allow for different sizes."

The UN is examining its regulations on crash testing and will determine whether they need to be changed to better protect all drivers.

If changes are made to involve a crash test dummy representing the average female, there is an expectation that women will one day be safer behind the wheel.

"My hope for the future is that the safety of vehicles will be assessed for both parts of the population," Dr Linder said.

[darkmaga-retard]

Uncover the shocking truth behind COVID-19 vaccines: contamination, hidden risks, and regulatory failures. Millions were exposed without informed consent—this fight is for accountability & justice.

Gaz's - A Defender's Voice

Sep 07, 2024

This video delves into the alleged concealment of critical information regarding the safety and efficacy of COVID-19 mRNA injections, focusing on how regulatory bodies and authorities misled the Australian public. It claims that significant contamination of genetic material was found in Pfizer and Moderna vaccines, far exceeding safety thresholds, with potential links to severe health risks like cancer and autoimmune diseases. Despite independent verification from multiple labs, global regulators, including Australia’s Therapeutic Goods Administration (TGA), dismissed concerns, claiming there was no safety risk without conducting proper tests.

The video argues that the mRNA injections are in fact gene therapies rather than traditional vaccines, citing how these injections modify genetic material within cells to stimulate an immune response. It criticizes the lack of rigorous testing on the long-term effects of this genetic modification, accusing manufacturers and health authorities of withholding important information about the risks, such as the bio-distribution of modified RNA throughout the body and its potential to disrupt cellular functions.

Legal challenges against Pfizer and Moderna are outlined, notably the case of Dr. Julian Fidge, who accused the companies of bypassing Australia’s regulatory requirements for gene therapies. The lawsuit was dismissed due to a lack of legal standing, but the video highlights potential conflicts of interest, including Judge Helen Rofe’s undisclosed connections to Pfizer. This raises questions about the integrity of the judicial process, especially regarding the dismissal of critical evidence related to genetic contamination.

[cannabisbusinessexecutive]

California legal weed industry in tumult after Times pesticide investigation

A scandal over California’s failure to keep pesticides out of legal cannabis is causing turmoil throughout the industry, with a whistleblower retaliation lawsuit, the departure of a top cannabis official, the state hiring a private investigator, and a race in the private sector to form a shadow regulatory system in the face of crumbling consumer confidence. Product testing, confidential lab…

[healthcaremarketanalysis]

Revolutionizing Healthcare: The Role of Cloud Computing in Modern Healthcare Technologies

In today’s digital era, cloud computing is transforming industries, and healthcare is no exception. The integration of cloud computing healthcare technologies is reshaping patient care, medical research, and healthcare management. Let’s explore how cloud computing is revolutionizing healthcare and the benefits it brings.

What is Cloud Computing in Healthcare?

Cloud computing in healthcare refers to the use of remote servers to store, manage, and process healthcare data, rather than relying on local servers or personal computers. This technology allows healthcare organizations to access vast amounts of data, collaborate with other institutions, and scale operations seamlessly.

Download PDF Brochure

Key Benefits of Cloud Computing in Healthcare

Enhanced Data Storage and Accessibility Cloud technology allows healthcare providers to store massive volumes of patient data, including medical records, images, and test results, securely. Clinicians can access this data from anywhere, ensuring that patient information is available for timely decision-making.

Improved Collaboration Cloud-based healthcare platforms enable easy sharing of patient data between healthcare providers, specialists, and labs. This facilitates better collaboration and more accurate diagnoses and treatment plans, especially in multi-disciplinary cases.

Cost Efficiency The cloud reduces the need for expensive hardware, software, and in-house IT teams. Healthcare providers only pay for the resources they use, making it a cost-effective solution. Additionally, the scalability of cloud systems ensures they can grow as healthcare organizations expand.

Better Data Security Protecting sensitive patient information is critical in healthcare. Cloud computing providers invest heavily in data security measures such as encryption, multi-factor authentication, and regular audits, ensuring compliance with regulatory standards like HIPAA.

Telemedicine and Remote Patient Monitoring Cloud computing powers telemedicine platforms, allowing patients to consult with doctors virtually, from the comfort of their homes. It also enables remote patient monitoring, where doctors can track patients' health metrics in real time, improving outcomes for chronic conditions.

Advanced Data Analytics The cloud supports the integration of advanced data analytics tools, including artificial intelligence (AI) and machine learning (ML), which can analyze large datasets to predict health trends, track disease outbreaks, and personalize treatment plans based on individual patient data.

Use Cases of Cloud Computing in Healthcare

Electronic Health Records (EHRs): Cloud-based EHRs allow healthcare providers to access and update patient records instantly, improving the quality of care.

Genomics and Precision Medicine: Cloud computing accelerates the processing of large datasets in genomics, supporting research and development in personalized medicine.

Hospital Information Systems (HIS): Cloud-powered HIS streamline hospital operations, from patient admissions to billing, improving efficiency.

Challenges in Cloud Computing for Healthcare

Despite its numerous benefits, there are challenges to implementing cloud computing in healthcare. These include:

Data Privacy Concerns: Although cloud providers offer robust security measures, healthcare organizations must ensure their systems are compliant with local and international regulations.

Integration with Legacy Systems: Many healthcare institutions still rely on outdated technology, making it challenging to integrate cloud solutions smoothly.

Staff Training: Healthcare professionals need adequate training to use cloud-based systems effectively.

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The Future of Cloud Computing in Healthcare

The future of healthcare will be increasingly cloud-centric. With advancements in AI, IoT, and big data analytics, cloud computing will continue to drive innovations in personalized medicine, population health management, and patient care. Additionally, with the growing trend of wearable devices and health apps, cloud computing will play a crucial role in integrating and managing data from diverse sources to provide a comprehensive view of patient health.

Conclusion

Cloud computing is not just a trend in healthcare; it is a transformative force driving the industry towards more efficient, secure, and patient-centric care. As healthcare organizations continue to adopt cloud technologies, we can expect to see improved patient outcomes, lower costs, and innovations that were once thought impossible.

Embracing cloud computing in healthcare is essential for any organization aiming to stay at the forefront of medical advancements and patient care.

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[transmutationisms]

do you have any methods for figuring out what supplements/supplement brands are trustworthy/effective? i’m just relying on reddit anecdotes and studies people link on there.

it depends whether there's any regulation in the country of manufacture/sale. if you mean in the us, fda does not regulate supplements like food, so you don't actually know whether they contain what the bottle claims. occasionally independent labs or scientific studies will investigate a specific supplement, so you can certainly look at those papers, but that information is only good as long as it's up to date—you don't know what, if anything, may have changed in their supply chain or manufacturing practices since then. like i don't mean to sound conspiratorial here but genuinely the only way to verify these label claims in the absence of a regulatory body you trust would be to like, test your supplements yourself lmao. otherwise im afraid it's just a guessing game of picking a brand you think you can trust for whatever reason

[harinibw]

On July 2, 2024, Ripple Labs made a significant move in its lengthy legal battle with the SEC by filing a crucial document with Judge Analisa Torres. Despite the SEC reducing its penalty demand from $2 billion to $102 million, Ripple declined the offer and submitted a Notice of Supplemental Authority to strengthen its stance against the SEC’s remedies and final judgment.

Ripple’s legal team, led by James Filan, argued that the Howey test is inadequate for digital assets like XRP and called for formal rulemaking to ensure regulatory clarity. They criticized the SEC’s reliance on varied court rulings, which could create inconsistent regulatory outcomes.

The SEC’s response is anticipated, especially after a recent ruling in SEC vs. Terraform Labs. At press time, XRP trades at $0.4743 with a market cap of $26.46 billion. The case's outcome could significantly impact the cryptocurrency market, potentially driving XRP prices up or down depending on the ruling.

[soniez]

From Lab to Patient – The Evolution of Medicine Production

The journey of a medicine from a research laboratory to a patient’s bedside is a complex and intricate process.  It involves rigorous scientific research, extensive clinical trials, stringent regulatory approvals, and sophisticated manufacturing processes.  This blog will explore the evolution of medicine production, highlighting the role of leading pharmaceutical companies in India, including Centurion Healthcare, in bringing life-saving medications to the market.

The Genesis of Medicine: Research and Development

The Role of Pharma Companies in India

The development of new medications begins with a deep understanding of diseases and the biological mechanisms that drive them.  Pharmaceutical companies in India, renowned for their robust R&D capabilities, play a pivotal role in this phase.  Researchers at these companies work tirelessly to identify potential therapeutic targets and develop compounds that can modulate these targets effectively.

Preclinical Research

Before a new drug can be tested in humans, it must undergo extensive preclinical research.  This involves laboratory and animal studies to assess the safety and efficacy of the compound.  The goal is to gather enough data to support the initiation of clinical trials.  This stage is crucial for ensuring that only the most promising and safe candidates move forward.

Clinical Trials:  Testing in Humans

Phase I Trials

Once a compound has shown promise in preclinical studies, it enters Phase I clinical trials.  These trials involve a small number of healthy volunteers and aim to evaluate the safety, tolerability, and pharmacokinetics of the drug.  For a medicine manufacturing company in India like Centurion Healthcare, this phase is critical for determining the initial safety profile of the drug.

Phase II Trials

If Phase I trials are successful, the drug progresses to Phase II trials, which involve a larger group of patients who have the condition the drug is intended to treat.  The focus here is on assessing the drug’s efficacy and further evaluating its safety.  Pharmaceutical companies in India invest heavily in this phase to gather robust data that can support the drug’s potential therapeutic benefits.

Phase III Trials

Phase III trials are the most extensive and involve a large number of patients across multiple locations.  These trials are designed to confirm the drug’s efficacy, monitor side effects, and compare it to standard treatments.  For a medicine manufacturing company, this phase is critical for obtaining the data needed for regulatory approval.

Regulatory Approval

After successful Phase III trials, the data is submitted to regulatory authorities for approval.  In India, the Central Drugs Standard Control Organization (CDSCO) is responsible for evaluating the safety and efficacy of new drugs.  Obtaining regulatory approval is a significant milestone for any medicine company in India, allowing the drug to be marketed and made available to patients.

Manufacturing:  From Lab Bench to Production Line

Scaling Up Production

Once a drug receives regulatory approval, the focus shifts to manufacturing.  Scaling up production from laboratory scale to commercial scale is a complex process that requires significant expertise and investment.  Medicine manufacturing companies in India, such as Centurion Healthcare, employ state-of-the-art technologies and adhere to stringent quality control measures to ensure that every batch of medicine meets the highest standards.

Quality Assurance and Control

Quality assurance and control are paramount in medicine manufacturing.  Companies implement rigorous testing protocols to ensure that each batch of the drug is consistent in terms of potency, purity, and safety.  This involves testing raw materials, in-process materials, and finished products.  Pharmaceutical companies in India are known for their stringent quality control measures, which are essential for maintaining the trust of healthcare providers and patients.

Packaging and Distribution

Once manufactured, the medicines are packaged in a manner that ensures their stability and safety during transportation and storage.  Packaging must protect the drug from environmental factors such as light, moisture, and temperature fluctuations.  After packaging, the medicines are distributed to pharmacies, hospitals, and clinics, ensuring that they are readily available to patients.

Post-Market Surveillance

The journey of a medicine does not end with its launch in the market.  Post-market surveillance is crucial for monitoring the drug’s performance in the real world.  This involves collecting and analyzing data on the drug’s safety and efficacy from patients and healthcare providers.  Pharmaceutical companies in India are actively involved in post-market surveillance to ensure that any potential issues are identified and addressed promptly.

Pharmacovigilance

Pharmacovigilance is a key component of post-market surveillance.  It involves the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems.  Medicine manufacturing companies in India have dedicated pharmacovigilance teams that monitor and report any adverse events associated with their drugs, ensuring patient safety.

The Role of Technology in Medicine Production

Advanced Manufacturing Technologies

The pharmaceutical industry has embraced advanced manufacturing technologies to enhance efficiency and product quality.  Techniques such as continuous manufacturing, automation, and advanced analytics are revolutionizing the way medicines are produced.  These technologies enable medicine manufacturing companies to produce drugs more efficiently, reduce waste, and ensure consistent product quality.

Digital Transformation

Digital transformation is playing a significant role in the evolution of medicine production.  Pharmaceutical companies in India are leveraging digital technologies such as artificial intelligence (AI), machine learning, and big data analytics to streamline their operations.  These technologies are used in various stages of drug development and manufacturing, from identifying new drug targets to optimizing production processes and ensuring quality control.

Sustainability in Medicine Production

Sustainability is becoming increasingly important in the pharmaceutical industry.  Companies are adopting environmentally friendly practices and technologies to minimize their environmental footprint.  This includes using renewable energy sources, reducing waste, and implementing green chemistry principles.  Medicine manufacturing companies in India are at the forefront of this movement, striving to make their production processes more sustainable.

Centurion Healthcare: Leading the Way

As a leading medicine manufacturing company in India, Centurion Healthcare is dedicated to advancing the field of medicine production.  Our commitment to quality, innovation, and sustainability sets us apart in the industry.  Here is how we are contributing to the evolution of medicine production:

Cutting-Edge Research and Development

Our R&D team is at the heart of our success.  We invest heavily in research to discover and develop new therapeutic agents that address unmet medical needs.  Our state-of-the-art facilities and collaboration with leading research institutions enable us to stay at the forefront of medical innovation.

Advanced Manufacturing Capabilities

At Centurion Healthcare, we utilize advanced manufacturing technologies to produce high-quality medicines efficiently.  Our manufacturing facilities are equipped with the latest equipment and adhere to international standards of quality and safety.  We are committed to continuous improvement and innovation in our production processes.

Comprehensive Quality Control

Quality is our top priority.  We have established rigorous quality control measures to ensure that every product we manufacture meets the highest standards.  From raw material testing to final product release, our quality assurance team meticulously monitors every step of the production process.

Commitment to Sustainability

We are committed to making our production processes more sustainable.  We have implemented various initiatives to reduce our environmental impact, including energy-efficient practices, waste reduction programs, and sustainable sourcing of raw materials.  Our goal is to contribute to a healthier planet while providing high-quality medicines to patients.

Conclusion

The evolution of medicine production is a testament to the dedication and innovation of pharmaceutical companies in India.  From the initial stages of research and development to the manufacturing and distribution of life-saving medications, every step in this journey is crucial.  At Centurion Healthcare, we are proud to be a part of this dynamic industry, contributing to the health and well-being of patients worldwide.

As a leading medicine company in India, we remain committed to advancing the field of medicine production through cutting-edge research, advanced manufacturing technologies, and a steadfast commitment to quality and sustainability.  Our journey from the lab to the patient’s bedside is driven by a passion for excellence and a desire to make a meaningful impact on global health.

[tyretestinglabinindia]

https://irmri.org/regulatory-testing-facility.html  Our industry provides the best regulatory testing services for India. IRMRI has a regulatory test facility, ready to ensure your product's quality, click now!

[mariacallous]

Before a sperm can fertilize an egg, it faces a long journey: Propelled by the back and forth movement of its tail, it needs to swim all the way through the female reproductive tract to the fallopian tube, where it meets an egg. But in a new study, researchers who want to develop on-demand male contraceptives say they’ve figured out a way to prevent pregnancy: temporarily stop the sperm from swimming.

In a paper published today in Nature Communications, the researchers announced that when they injected 52 male mice with an experimental compound called TDI-11861, it temporarily inhibited an enzyme that helps sperm move. When they paired the males off with females to mate, no pregnancies occurred. (The same number of male mice treated with a control substance impregnated almost one-third of their mates.) The effects lasted for up to two and half hours. At around three hours, some sperm started moving again, and by 24 hours, nearly all sperm recovered normal movement. The authors say the results point the way to a short-term birth control option for men.

“It’s pretty clear that this is an on-off switch for sperm,” says Lonny Levin, a professor of pharmacology at Weill Cornell Medicine in New York, and an author on the paper. “We thought inhibiting this would be a great way to stop sperm in their tracks, prevent them from ever leaving the vagina and getting to the promised land to fertilize an egg.” 

But injecting a drug before sex isn’t exactly an appealing idea, so the researchers also tested an oral version in male mice and confirmed that the drug immobilized sperm when delivered this way. This method of birth control doesn’t contain hormones, as pills for women do. The idea is that it could be taken shortly before sex, rather than daily. “I think this is really one of the biggest advancements for non-hormonal contraceptives in recent times,” says Christopher Lindsey, a program official in the National Institute of Child Health and Human Development, which partly funded the work. 

Levin and his collaborator Jochen Buck, also a professor of pharmacology at Weill Cornell, didn’t initially set out to find a male contraceptive. They were studying a regulatory enzyme called soluble adenylyl cyclase, or sAC, which is found in almost every cell. When they genetically engineered mice to lack this enzyme, they found that the males were infertile. The enzyme appears to play a major role in activating a sperm cell’s ability to swim.

That led the researchers on a new quest to develop a potential male contraceptive by designing compounds that could block sAC. But because this enzyme is present elsewhere in the body—and may be necessary for other cellular functions—they didn’t think it would be a good idea to shut it off permanently.

In 2018, Melanie Balbach, a postdoctoral associate in their lab, gave one of those experimental compounds to mice and found that it produced sperm that could not propel themselves forward. “They didn't move. They didn't twitch,” Levin says. But that compound lost its effect once it entered the female reproductive tract. So the researchers kept testing compounds that would keep sperm immobile. 

Over time, they refined TDI-11861. In mice, the drug didn’t appear to interfere with sexual functioning or cause any side effects. And most importantly, the sperm were normal again a day later. 

Of course, there is a big caveat: Mice are not people. But humans also have the sAC enzyme, and in males, it’s also involved in sperm movement. Buck and Levin are reassured that the strategy might be safe in people by another team’s report from 2019, which described two infertile men with mutations in the gene that makes sAC. The men were otherwise healthy, except for having a higher risk of kidney stones. (Mice bred without this gene have elevated eye pressure, which wasn’t a problem found in the men without the gene.) 

To test the safety of their compound, the Cornell team continuously infused it into male and female mice via a pump for six weeks. They noted no side effects, including no kidney issues. They’re now testing the compound in rabbits, which have reproductive organs that are more similar to those of humans. 

Many efforts to create male contraceptives have used hormones—primarily testosterone—to suppress sperm production. But like hormonal birth control for women, these drugs can have an array of negative side effects, including mood swings, weight gain, and decreased libido. Both female and male hormonal birth control also take weeks to become fully effective at preventing pregnancy. A trial sponsored by the National Institutes of Health that’s testing a hormonal gel for men is showing promising results, but the gel must be applied daily to the shoulders to keep sperm levels low enough for effective contraception. 

Some men might prefer a non-hormonal, temporary option. “I think it’s a really wonderful idea and would be very much appreciated by a lot of people who would not maybe want to take a pill every day,” says Gunda Georg, a professor of medicinal chemistry at the University of Minnesota, who researches male and female contraceptives and wasn’t involved in the new work. “I think we need to have many different options for contraception for men and also for women.” 

Georg’s lab developed a non-hormonal pill, dubbed YCT529, that targets a protein called retinoic acid receptor alpha and is involved in sperm formation. In mice, it greatly reduced sperm counts and was 99 percent effective at preventing pregnancy after being given daily for four weeks. 

While Buck and Levin are also working toward a pill, these are less efficient at delivering drugs than injections. The stomach tends to degrade them, and Levin says the current version of their compound would need to be a pretty large pill. The researchers have launched a company, Sacyl Pharmaceuticals, to further refine their sAC inhibitors and advance them to human clinical trials. “We're trying to get a compound that will be a nice, small pill,” Levin says. 

They also acknowledge that the current compound wears off too quickly, which could result in unwanted pregnancies if not taken at exactly the right time, so they’re hoping to extend the window of effectiveness to 18 hours or so. While there’s still a lot of testing ahead, if all goes well, maybe it will play a role in future Valentine’s Days. “Presumably, you could take this over dinner, and then within an hour, similar to Viagra, you would be ready to engage in sexual activity,” Lindsey says. 

[journeythroughbible]

Small Farms and Seeds

If you are not aware, small farms are going away. Large corporate farms are buying many out, and the ones who try to remain get squeezed until many just give up. One local farm had a booming produce stand and provided great service to the community. Still, they finally closed and went to hay only since they could run that with just family members AND did not have regulatory problems.

Now I am not getting into all the regulations our government adds or the fact that they could not afford or find employees during covid and the explosion of weed farms. One of the issues I would like to focus on that helped their closing was seeds. They were a family farm and would set aside some of the harvest for next year's seeds. Well, with corporate farms nearby, this became a problem.

Seed companies are doing all they can to corner the market. Companies like Monsanto have made patented seeds that control pests eating them. You cannot hold back the harvest for these seeds; you must replant with new ones. I do not have a problem when a farm decides to do this for business reasons. The small family farm that purchased seed outside the seed company and holds back their seeds now has another expense, testing their seeds.

Nature is such that one field with patented Seed Co's seeds and one with family seed experiences cross-pollination. Because of this, Seed Co now has the right to force you to test your seeds to ensure no cross-pollination. If nature did its thing and you now have Seed Co patented seed-producing plants, you must pay Seed Co for the seeds or destroy the seeds held back. This additional expense causes the small farm to close and forces the large farms to purchase Seed Co seed from that point forward.

If a farm, at no fault of their own, now has corrupted seeds, Seed Co should not be able to force undue burden on the farms to clean their supply or pay for something that once was free. Because of this, I suggest our local governments get on board to correct this with the following bullet points:

Farms should bear no costs in the testing of their seeds.

The seed company should bear the costs of cleaning and replanting contaminated farms. This "clean up" expense should not affect the current crop until after harvest.

Seed companies should bear the costs of having their products tested by an independent lab to ensure the "patented" seed is not harmful to the environment or from consuming these products.

The ultimate resolution should be that plants/seeds that can naturally progress should not be patentable.

DISCLAIMER – This is all from first and second-hand discussions with farmers, and not sure if they misrepresented these claims. If any problems, PLEASE comment below.

[ai-digital-marketing]

The Marvelous Journey of PaperCup: A Tale of Grit, Grind, and Glory

Once upon a time, in the bustling city of San Francisco, two starry-eyed entrepreneurs, Sarah and Alex, embarked on a daring adventure. Fueled by their shared passion for sustainability, they decided to tackle the mounting problem of single-use plastic waste. They founded PaperCup, a startup committed to revolutionizing the world of disposable cups by making them 100% biodegradable and eco-friendly.In the beginning, Sarah and Alex faced an uphill battle. They were armed with nothing more than a brilliant idea and a garage-turned-lab where they tirelessly experimented to perfect their product. Their enthusiasm and determination knew no bounds, but challenges lurked around every corner.The first roadblock they encountered was financing their dream. Without adequate funding, they wouldn't be able to mass-produce their eco-friendly cups. This dilemma led them to knock on countless doors, pitching their idea to skeptical investors. It took persistence and an unyielding belief in their vision, but eventually, a handful of angel investors saw the potential in PaperCup and backed the venture.With funding in place, Sarah and Alex continued their quest. They knew that to stand out in the saturated market, they had to craft a unique marketing campaign that would resonate with their target audience. They devised an ingenious growth hack: they would collaborate with popular cafes and coffee shops to offer customers discounts on their favorite drinks when served in a PaperCup. This strategy not only increased brand visibility but also aligned with the cafes' sustainability goals. The cups became a hit, and word-of-mouth marketing quickly spread like wildfire.As with any true adventure, there were plenty of obstacles that tested their resolve. One particularly daunting hurdle was navigating the complex web of regulatory compliance. In their pursuit to create a cup that could break down completely within a year, Sarah and Alex had to ensure their product met strict environmental standards. After several iterations and extensive lab testing, they finally achieved a winning formula that was both eco-friendly and compliant with regulations.It seemed that their hard work was beginning to pay off, but an unforeseen challenge loomed on the horizon. A global pandemic threatened to derail their progress, forcing businesses to shut down and bringing the world to a standstill. PaperCup was no exception, as cafes and coffee shops closed their doors, and demand for their cups plummeted.Sarah and Alex knew they had to act quickly to keep their dream alive. They pivoted their business model, harnessing the power of e-commerce to sell directly to consumers. With a renewed focus on home-brewed coffee and tea, they expanded their product line to include a range of biodegradable coffee filters, stirrers, and even tea bags. Their unwavering determination turned a potential crisis into a golden opportunity.Today, PaperCup stands as a shining example of innovation, resilience, and the power of human spirit. They have not only transformed the disposable cup industry but also inspired a movement towards a more sustainable future. Their journey is a testament to the fact that with passion, perseverance, and a little bit of ingenuity, even the most audacious dreams can become reality.And so, dear reader, as you sip your coffee from a PaperCup and reflect on the tale of Sarah and Alex, remember that the seeds of greatness lie within each of us. All it takes is the courage to chase your dreams, embrace the struggles, and turn adversity into opportunity. Who knows, you might just be the next PaperCup in the making. Key Takeaways

Passion and determination can turn dreams into reality, even when faced with numerous challenges.

Securing funding is crucial for a startup's growth, but it requires persistence and belief in one's vision.

Unique marketing strategies, such as collaboration and growth hacks, can help a startup stand out in a crowded market.

Regulatory compliance is an essential aspect of product development, particularly in the sustainability sector.

The ability to pivot and adapt to changing circumstances can turn potential crises into golden opportunities.

[darkmaga-retard]

Uncover the shocking truth behind COVID-19 vaccines: contamination, hidden risks, and regulatory failures. Millions were exposed without informed consent—this fight is for accountability & justice.

2nd Smartest Guy in the World

Sep 12, 2024

An important clarification on the below video is that it incorrectly states that the BigPharma manufacturers did not know nor test the dangers of their slow kill bioweapon “vaccines,” but this is untrue; they and their patent holder Intelligence Industrial Complex handlers all knew the exact nature of these gene altering cytotoxic spike protein inducing poisons.

This was always a deliberate global eugenics program.

by Gaz’s - A Defender’s Voice

This video delves into the alleged concealment of critical information regarding the safety and efficacy of COVID-19 mRNA injections, focusing on how regulatory bodies and authorities misled the Australian public. It claims that significant contamination of genetic material was found in Pfizer and Moderna vaccines, far exceeding safety thresholds, with potential links to severe health risks like cancer and autoimmune diseases. Despite independent verification from multiple labs, global regulators, including Australia’s Therapeutic Goods Administration (TGA), dismissed concerns, claiming there was no safety risk without conducting proper tests.

The video argues that the mRNA injections are in fact gene therapies rather than traditional vaccines, citing how these injections modify genetic material within cells to stimulate an immune response. It criticizes the lack of rigorous testing on the long-term effects of this genetic modification, accusing manufacturers and health authorities of withholding important information about the risks, such as the bio-distribution of modified RNA throughout the body and its potential to disrupt cellular functions.

Legal challenges against Pfizer and Moderna are outlined, notably the case of Dr. Julian Fidge, who accused the companies of bypassing Australia’s regulatory requirements for gene therapies. The lawsuit was dismissed due to a lack of legal standing, but the video highlights potential conflicts of interest, including Judge Helen Rofe’s undisclosed connections to Pfizer. This raises questions about the integrity of the judicial process, especially regarding the dismissal of critical evidence related to genetic contamination.

[mpplstandard]

Proficiency Testing Providers for Laboratories: Ensuring Accuracy and Reliability

Proficiency testing (PT) is a vital component in ensuring the accuracy and reliability of laboratory results. By participating in proficiency testing, laboratories can compare their performance with other labs and maintain high standards of quality. Proficiency Testing Providers play a crucial role in this process by offering various testing programs tailored to specific industries and testing requirements.

What Are Proficiency Testing Providers?

Proficiency Testing Providers are organizations that design and administer PT programs. These programs allow laboratories to evaluate their testing accuracy by comparing results with peers. Providers offer testing samples, analyze the results, and offer feedback, helping labs identify areas of improvement.

Key Benefits of Proficiency Testing

Quality Assurance: Participation in PT programs helps laboratories ensure consistent and accurate results.

Benchmarking Performance: PT programs allow laboratories to compare their performance against others in the industry.

Regulatory Compliance: Many industries require laboratories to participate in proficiency testing for accreditation purposes.

Confidence in Results: By regularly participating in PT, laboratories can enhance confidence in their testing procedures and results.

Choosing the Right Proficiency Testing Provider

When selecting a Proficiency Testing Provider, laboratories should consider:

Industry-Specific Programs: Ensure the provider offers tests relevant to your specific industry and testing needs.

Accreditation: Choose providers accredited by recognized bodies, ensuring the tests meet international standards.

Support and Guidance: Opt for providers offering comprehensive support and detailed feedback to help improve your lab’s performance.

Conclusion

For laboratories aiming to maintain accuracy, reliability, and compliance, partnering with trusted Proficiency Testing Providers is essential. They provide invaluable support in benchmarking and improving laboratory performance, ensuring the highest standards in testing quality. Looking for a reliable proficiency testing provider? MPPL Standards offers tailored PT programs to help your laboratory achieve excellence. Contact MPPL Standards today to learn how we can support your lab’s quality assurance efforts!