#and they'll be like is this a coffee

[kedreeva]

Do you think you could give your opinions on the recessive / lethal yellow genes in mice? Do you think you'd ever consider breeding recessive yellow? (If you haven't already.) I'm just super curious about your thoughts on them as I don't really know a lot about genetics. Do you think it's possible to breed a consistently healthy line of yellow mice? I'm just super curious to hear your thoughts as a breeder

Well, this is a kind of long answer and I'll warn it discusses animal death, so I'll put it behind a cut.

Personally, I wouldn't, but not because of ethics concerns; I just don't like any of the colors made with RY/AY. They're just not visually appealing to me. I had a couple RY pop up from the Taylor black line when I first got it, and they were just enh. A good, rich red, esp a satin red, can be a really perfect looking mouse... but by god that's years of work and it never ends because Red is such a hard phenotype to maintain and I'm just not that determined. I'm convinced that people breed for red because seeing it opens all the ferret cages in their brain, not because they can be normal about it. If you want good reds, it's like you dedicate your life (and mousery) to it or you don't do it, and my life's already dedicated to the peafowl. My mousery is already dedicated to blacks and tricolors.

As for the AY gene itself, it's a "lethal" gene in that homozygosity is lethal but it's lethal at the blastocyst stage so it's not really an ethical problem imo. If it was lethal as in the pups deteriorate and die post partum, or if it caused well developed pups to die/be stillborn such that it caused the dam health risks, then it would be a problem. But, it doesn't. You just get smaller litters because some cells die way early on and get reabsorbed. I don't really have any problems with that. Show breeders cull litters down to 4-6 pups (for dam and pup health reasons), so it's not like all of them would be turning into adults anyway.

As for the genetic issues with the adult mice, there are three major health issues. The first is obesity (sort of), and the major problem there is keeping them in breeding shape (meaning, capable of doing the do at all). Curiously, in at least one study I remember seeing, there's a difference between an obese mouse of X color mutation and an AY that's considered obese because of its natural body type; for example, an obese black mouse will likely have a shortened lifespan, whereas an AY mouse doesn't (at least not less than any other mouse color mutation) unless it's obese for an AY. So this isn't really a problem as long as the breeder is watching their diet and ensuring they stay fit for their body type.

The other two genetic problems actually are health issues related directly to the AY gene, and that's being prone to diabetes and to tumors. However, these are both things that (any good) breeders would notice, cull, and therefore not breed forward, in order to keep the line as free from them as possible. Which really isn't any different than any other line that develops health problems of any sort. People don't keep health problems. A good breeder should be and usually is aware of the potential health problems in the lines they are breeding, particularly if it's a genetic one that can't be avoided (like you can't avoid AY if you're breeding AY), and will know what to look for and intervene as soon as possible. Diabetic mice urinate excessively so it's REALLY noticeable, and tumors... well. Hard to miss. And tumors of various sorts is a fairly common "select away from/cull" problem in any mutation, it's just slightly higher risk in AY.

So the short answer, in my opinion, AY isn't really an unethical gene to work with. It's not one I'd choose to work with, but I don't think the people who do are doing anything wrong just for working with the gene at all. It comes down to the same ethics as any other mutation; working to maintain body condition and selecting for health.

Honestly, out of all the animals I've seen bred and bred myself, I think mouse breeders in general have proven themselves to be the most concerned with what's best for the animal, not the breeder. The show clubs like FMBA and AFRMA etc won't recognize standards for things like snub noses or manx tails or anything else that would potentially seriously impact QoL by nature of existing at all, and at least in the groups I'm in, the members are not shy about recognizing when health problems mean no breeding for a mouse regardless of how pretty or sweet. When someone newer asks what to do, I've never seen anyone support trying to breed a mouse with issues, or usually even keep one whose QoL would be poor. They are very familiar with the kindest thing you can do is let them go. It's a breath of fresh air from the goddamn chicken groups, who will limp along any bird that's still breathing regardless of what's best for the bird.

I think the only morph I've seen that I have an ethical problem with is the X-brindle gene, which is a "brindle" gene on the X chromosome that causes the mouse to be unable to absorb copper. This means that the males DO founder and die after birth (which means most people just humanely euthanize the male pups, they aren't out here letting them suffer that I've seen), and females get a strange coat color and curled whiskers from low copper absorption. Does have a second X gene that's clean so they still can, but it's really an unnecessary mutation to continue imo. It hasn't been recognized by the show clubs that I know of, but idk if they can be shown under normal brindle or if you can tell at a glance, as I don't really know as much about them or any of the AY gene specifics. I have basic knowledge but since i don't breed them myself it's very in passing knowledge. I know it's rarely bred or worked with in the first place, and I hope it stays that way or disappears entirely.

[transmechanicus]

Really fucked up that two ppl can care about each other and make their best efforts to communicate and still end up hurting each other so badly they cannot stand to be in the same room.

[jeanharlowseyebrows]

other people have and will say it better than i ever could, but the ongoing theme of. you create your reality. no i didn’t kill someone. i wasn’t even there. that didn’t happen. their self-contained little world in which they’re always playing and everything can be erased and put back to the start. so busy with what’s going on in front of them that they never look around and realize they’re in a cage. once or twice there are those moments of -- i can choose something else i can do something else. i can write my own future, a new future. but in the end they can’t fathom anything other than this. the world their father built. sitting in a car and becoming your mother to start the game all over again.

[ddarker-dreams]

chrollo suggests that you should get a spiderweb tattoo. if you make the mistake of asking why, he'll tell you without the least hint of embarrassment, that it's 'because you've ensnared him.'

[meganechan05]

"While we're here, why don't we have tea?"

"I'm impartial."

"Would your impartiality really be skewed with just one cup of tea?"

"...I suppose just one wouldn't hurt..."

(A bubble tea place had this photo op area so I snapped a photo and plopped HimeRita onto the couch as sitting pose practice)

[longagoitwastuesday]

I am liking Jujutsu Kaisen, way more than I imagined I would, but I foresee it will let me down and it's keeping me from enjoying this as much as I could haha

I think the characters and dynamics are well set, and I think many of them have an incredibly good and deep potential, but I would be willing to bet they'll not get a proper development, enough for them to really hit. A well assembled set of gears is not enough to make the movement go, you have to wind the clockwork.

I think Gojo and Megumi have a fascinating and very complex dynamic, but I doubt it will be given the time and care that imo it needs to actually work. And it is going well enough for now! One could see the intimacy between them was deeper than the one Gojo had with, say, Yuji and Nobara ever since the very first few episodes despite the fact Fushiguro too was a first year. But the pieces forming what they have are extremely complex, and it just wouldn't be realistic if it doesn't show, even if in a not showing way, or if it doesn't have consequences or implications.

It's one of those dynamics that shape one's life, the way one regards the world, the way one establishes or not relationships with other people. It's one of those dynamics that could be full of fondness, gratitude, resentment, admiration, trust, and that imply intimacy, the good kind or the bad, even if in just the knowledge of someone who's been a constant through your life. It could, and would, imply a myriad of feelings, and probably in such a mix it could imply contradictory feelings too. Even the nothingness would weight, even the nothingness would be significant and meaningful.

Gojo took Megumi and his sister under his wing, the son of a man who murdered him, because of both selfish and selfless reasons. Megumi looks like Toji. What does Gojo feel about this? How does Gojo deal with this? How does Gojo go about taking care of Megumi? Would he walk him to school? Make him breakfast? Celebrate his birthdays making him blow candles? Did he take him to the zoo? Does the relationship between them feel professional or is it something more? Gojo appreciates his students, but is Megumi to him just another student? When Gojo faces Sukuna in Megumi's body, did he see the kid he raised, or does he just see Sukuna in one of his students' body? Did he have one faint wavering instant? And how does Megumi feel about this? Is he resentful of him? Resentful of the situation? Of the selfishness behind his actions? Does he feel like a pawn? Is he grateful? Does he resent feeling grateful? Would he rather not? Does he love Gojo? Does he feel nothing about him other than what he could feel about a teacher that sort of annoys him but knows he's reliable in his strength? Does he think it unfair, cruel or unfeeling that Gojo is close, closer perhaps, with Yuuji or Yuta, considering their story? When Sukuna slices Gojo in two, does the remnants of Megumi's soul tremble?

And not just Megumi and Gojo. Yuuji and Nanami, Gojo and Nanami, Yuuji and Fushiguro, Nobara and the boys, or Nobara and Maki, Todo and Yuuji or Yuta, Gojo and Yuta, Megumi and his sister. Gojo and Geto, even! If the pieces are well set, the dynamics are intriguing, interesting, and have potential to be deep, but then the characters have like two plot relevant scenes that punch you hard, but little more, it's not nearly enough. Especially not nearly enough for the enormity that is shonen dynamics and situations. And the potential existing at all, and then not delivering, makes it all the more frustrating when you're left with something mediocre that could have been so good.

The development of dynamics through not only a few plot relevant gut wrenching moving scenes, but also the smallness of life, is important. The friend who recommended this to me said that those things were just unnecessary filler, but I disagree. I think there's a big difference between a large amount of anime-only filler episodes whose existence is based on the fact they had run out of manga chapters to animate, and moments of quietness. The low stakes character-driven moments of quietness can be so telling and so insightful, and they are so satisfactory when brought back later in higher stakes situations. My friend teased me there was no scene of Gojo making breakfast to Megumi, that it would be an idiotic idea, but it would be so telling. How he makes breakfast, what they eat, if he tries hard or if it's all mechanised, if they have personal bowls or if they use whatever, if he just buys them some pastry on the way to school, if the way they have breakfast changes through the years, or if he doesn't make them breakfast at all! All that would be very insightful on their dynamic and its evolution. All that would give a glimpse on how they regard each other and why, even in the present. All that could become meaningful in tense situations and high stakes scenes.

These moments also let the plot breath; if a lot is happening all the time, if every character is always experiencing trauma after trauma, the entire story is so emotionally draining that at some point you don't even care all that much. Besides, these nothing moments or low stakes plot arcs, besides deepening and developing dynamics, also let some in-world time pass, which would make the intimacy and bond between characters more believable imo; between Yuuji eating Sukuna's finger and their last confrontation in December how much time has passed? A few months? Am I truly to believe these characters are so everything to each other in only a few months?

Without some smallness, some repetition, some daily life, some low stakes not plot-centric development, the dynamics don't hit, they don't truly feel fleshed out, and dynamics as complex as the ones Megumi and Gojo have, or as supposedly meaningful as the one Megumi has with Yuuji or his sister, should be fleshed out if they're going to exist at all. Otherwise they'd risk making the writing feel awkward and fake. Besides, if the dynamics felt well fleshed out and realistic, they would shape the way the characters interact and act, and how they deal with situations, thus being plot relevant.

The shonen genre has so much happening all the time, the stakes are so high, the dynamics are so rooted in big events and the relationships carry enormous weight and implications. Yet they barely get developed, and it feels so stupid, so plain, the absence of something so important noticeable like a constant void, a shapeless nothingness present in every scene. It makes the characters feel like cardboard figures. Jujutsu Kaisen is already getting a better job than many, but I doubt it will do enough for what I've heard, and I fear I am bound to feel let down, and bound to feel unmoved.

After all, if not enough time and care has been given to develop a dynamic, I am not going to feel pressured by the high stakes; if not enough time and care has been given to develop the dynamic between Megumi and Yuuji, as good potential as it has I am bound to feel little for this last confrontation between Sukuna and Itadori, and his effort in getting Megumi back.

[winepresswrath]

The thing about Crowley is that he already tried fighting* the system and the end result was his fellow rebels making a new system suspiciously similar to the old system with torture pits and demotivational posters in place of the aggressive hypocrisy and kardashiancore interior decorating. And then after that he decided to fight the apocalypse and the apocalypse thwarted itself with minimal involvement required from him. His biggest contribution was fucking up a simple handoff completely accidentally. His apparent belief that it'll all sort itself out without him or it won't and either way his involvement will be largely irrelevant to everyone but himself is pretty well founded. I'm sure by the end of season three he'll have learned a valuable lesson about how admitting that you want to make positive contributions to the world is something you can do on your own terms and not simply an exercise in opening yourself up to god's preordained judgement and hell's torture pits and but he's old and tired and has probably never been kissed let him have a very specific vision for his retirement.

*ok his version of fighting was probably just asking a lot of very annoying questions and then semi-accidentally joining a rebellion.

[jaggededges123]

"born to be an event writer forced to be a mod" i've made this my discord status because it is extremely Me jsafklsdjkflajsdl

[loving-jack-kelly]

au where jack and davey start out as random roommates/craigslist roommates or something similar and only see each other at four am bc that's usually when jack is waking up to start his day and when davey is finally going to bed

[lesbiancarat]

really hope booseoksoon keep up the concept of being a rookie group for their comeback, they're comedians at heart i'm trusting them to commit to the bit

[skrunksthatwunk]

unfortunately i have found myself mildly captivated by a fancy caffeinated drink. this is bad bc I've avoided coffee all this time and now im being defeated. by $6 cold brew shake orz

[starthelostboys]

i just know that none of the lost boys have drank water in at least a decade

[carcarrot]

highlight of the interview was the 80s music playing in the background

[secretlyavastavatar]

@thechieflibrarian I think we found one of your Leitners, cuz one of my underlings read a book cuz he was bored...and now we have random-ass doors to nowhere showing up and trying to eat people all over the warehouse. Nothing's eaten anyone YET, but with these idiots it's only a matter of time before they start throwing artifacts through to see what happens.

I have NOT had enough caffeine to deal with this today....

[richardgrimes]

it's actually so sinister that you can reblog posts from palestinians who are begging for help because their loved ones are getting killed or on the verge of dying and zionists will come in your inbox trying to argue with you about it. what the hell is wrong with you truly. like something is deeply disturbed within you. get better for the sake of the people that come across your path. thanks!

[salvadorbonaparte]

After "not having running water on two separate days this month" now the long awaited sequel "not having electricity for two days next month"