#but it’s not as aggressive as a malignant disease?

[321sluggie]

Gross shit in tags

[reasonsforhope]

"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.

The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.

“These clusters alert the immune system in a much more profound way than single particles would.”

Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.

“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.

“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).

Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.

The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.

In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.

The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...

While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.

The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."

-via Good News Network, May 11, 2024

-video via University of Florida Health, May 1, 2024

[grits-galraisedinthesouth]

The Princess delivered such a clear & well written statement for the layperson. She displayed unparalleled poise, courage, and compassion under the harshness of the global spotlight.

I feel for her. Unlike Charles (IMO), Catherine never anticipated that she might have been battling cancer symptoms. Hearing the pathology results was devastating. They deserve our compassion.

And yet THIS:

Knowledge is Power

I already created a post to help the layperson better understand "preventative chemotherapy."

The use of preventative chemotherapy means Catherine's lymphatic system is concerning and warranted aggressive action to ensure that she is cured of this disease.

Sometimes a malignant tumor is removed and the body is cancer free [Sarah York/Guiliani Rancic].

Thankfully Catherine's magins are cancer free as there is no evidence the cancer metastasized.

Despite those cancer free margins, the cancer gained access to the lymph channels (not her lymph nodes), hence she was prescribed a course of a "preventative" form of poison (chemotherapy) to arrest & annihilate the wandering cancer cells in every system of her body. 😥

[fanaroff]

DP X Infection AU: Mosquito Malignance [Malignance] *More art and info beneath the cut.

Recovered Written Fenton Files — Infection Dubbed "Malignance" Estimated Start Date: Two weeks prior Status: Ongoing Threat Level: Cocked Pistol The Doctor known as "Spectra" released a swarm of mosquitoes with tainted or corrupted ectoplasm upon the town of Amity Park, located in Illinois. All known cases of infection have been lethal and incurable insofar. The mosquitoes appear ghostly in nature, even outside of the corrupted ectoplasm, and have been documented intangibly entering a victim's skin rather than biting. Infection is immediate and the removal of tainted areas (such as via amputation) has proven ineffective at stopping the disease. The infection seems to mimic perceived 'ghostly abilities' and have been nicknamed 'ghosts.' It is assumed the disease was created by Dr. Penelope Spectra and her assistant, Bertrand, illegally within their home lab. It is spreading rapidly and no one has been able to approach the lab as Dr. Spectra and her assistant (both in late stages of the infection) are haunting the entrances.

Stage One: Patient will immediately feel weak and lightheaded. There is a chance of fainting. The area of skin the mosquito enters will begin to turn green, bumpy, and rubbery. Rather than any direct pain, pins and needles or 'static' will be felt in all affected areas. Brain fog begins. They are extremely contagious from the start, touching infected areas can spread it.

Stage Two: The green affected areas will spread quicker, making an obvious path towards the heart. A faint glow starts around these areas. Patient begins to loose cognizance, forgetting where they are and what is happening. The tend to focus on one thing and obsess about it. 'Obsessions' have been useful in keeping rowdier patients corralled. Teeth and fingernails have been observed to being lengthening. Intangibility of the affected areas happens on and off. Most have been observed to only have the skin turn intangible. Multiple cases have cropped up where a patient moves an extremity while the skin is intangible and have accidentally separated the skin from their muscle and bones. Several have exhibited red bleeding into their pupils. Patients begin to try and wander about. Some float inches off of the ground. They are still able to somewhat communicate at this stage. Stage Three: Patients loose all sense of self as the infection reaches the heart. There is no longer any ability to communicate with the affected outside of leading them to specific areas and distracted them with their 'Obsessions.' Distortions and decay begin in the extremities. There pupils begin to change size and shape, normally growing larger. Any noises made are guttural and interspersed with static. Mainly aggressive but distractions can keep them content. Some drool corrupted ectoplasm. It is recommended to not interact with any dropped fluids, they are still highly contagious. Any glow begins to brighten, tongue turns green. Stage Four: Patients begin to morph and decay at high speeds. Their bodies are attempting to twist into shapes that have to do, or seem to, with apparent Obsessions. They begin to only scream in what sounds like static at this stage. Green flesh can start to drop off and expose glowing bones. Some have new bones growing through their skin. Pupils have entirely taken up the eye and are red in color with large black irises. Stretching, twisting, and drooping can occur. Patient no longer looks human in appearance. Their skin is almost fully green. Some have the ability to turn invisible and are able to pass intangibly and invisibly into the bunkers of survivors. Stage Five: Patient is fully green, teeth sharp, and fingers into claws. Bone claws have become a common sight. Their eyes are either fully red or fully black in color. Green ectoplasm is constantly leaking from orifices and wounds— The file is cut off here with one last line at the end. "My son has been infected. I must do what I can do find a cure."

I was asked by a friend to try my take at a Danny Phantom Infection Au, since they hadn't seen one in the fandom yet and neither had I. I'm basing mine off of the episode "Doctor's Disorders" when those ghostly mosquitoes cause all of the highschoolers to gain a temporary ghostly illness. Except, in this it's not so temporary and the effects are much, much worse. Most of the show does not happen in this. The 'ghosts' are not the show ghosts but the term used for those in the late stages of the disease and stuck with ghostly figures, powers, obsessions, and a continuous need to spread. They can only be distracted by "obsessions" that the infected begin to ramble about in Stage Two. Danny is infected but his exposure to ectoplasm from a young age keeps him cognizant and docile until his mother is able to create a cure from Vlad Masters, a family friend who turns out to be immune due to an incident in their college years. This 'cure' only works on those exposed who have been exposed to ectoplasm in their lives before the apocalypse. Danny, upon receiving the cure, was able to keep the powers granted to him by his infection and uses this to be able to see where invisible ghosts are as well as stop them from approaching survivors just by being in the vicinity of them. A cure is able to be developed from him for normal people that have not been exposed to ectoplasm before. This only works for those in Stage One. When someone is cured, their hair turns white and their eyes turn the same green as the ectoplasm. These people are called "Halfas." So far, story wise, only three exist.

[ceilingfan5]

make it count

"problem" for @taznovembercelebration

Kravitz thought he was already having a weird night, but the guy tumbling out of his closet was, honestly, a real surprise. 

“AUGH, FUCK,” Kravitz says, flawlessy parried by closet guy’s “FUCK, AUGH.”

Kravitz steps back. Too far. The bed catches his ass, which hopefully looks like he sat down intentionally and didn’t reverse kneecap himself. Closet guy straightens up, long, gorgeous hair all over the place, and he spits hair out of his mouth and eyes Kravitz, steely, but also nervous, like Kravitz might be angling to kick his ass. 

Kravitz might. He hasn’t decided yet. He’s a little panicked, and he doesn’t like, WANT to call the cops, obviously, but there’s a fuckin’ dude in his closet and he’s been home for like three hours now. He’s played dad rock as high as his phone could go and danced in his boxers, and showered, and changed into pajamas, and eaten popcorn like both a horse and the tender but misunderstood delinquent girl feeding that horse and maybe that’s not necessarily something he wanted some kind of malignant fucknugget to witness.

“Who the fuck are you and how did you get in my apartment??” he demands, grabbing the nearest heavy object and brandishing his shitty lamp that makes an annoying noise when it’s on like it’s some kind of newfangled glaive-mace. 

“Who the fuck are you and where am I?” closet guy retorts aggressively, in a funny accent Kravitz can’t really place. Maybe it’s fake. Is this guy fucking with him? He’s too tired to be fucked with. He won’t allow it. 

“My apartment, asshole, keep up!” 

“Answer the first question!”

“You first!” Kravitz juts with the lamp, which is unfortunately a little flaccid, what with its flexible spine and all. He should have grabbed a shoe and just chucked it. 

“I don’t remember what you said!” the guy admits, which, okay, Kravitz kind of gets it, and it’s sort of hard to stay serious, even with his hackles up as they are. “Why are you dressed like that?”

“I’m in my pajamas!” Kravitz says, defensive. He knows the old, old Death Note t-shirt and Jack Skellington pants, which he got from the defunct K-mart mumble years ago, are not like. Flattering. BUT!! Listen. His vintage monogrammed pjs are in the dirty pile. And the dirty pile has gotten a little big, cause things have been nuts at work, and he’s worn out and exhausted and other words for fuckin’ wiped. What is it people say now. Eepy? Baby you’d best believe he’s eepy to the core like some kind of fucking blood disease. 

Man. Maybe he should get his vitamins checked. 

But also fuck you, closet guy, he’s in his own home, and no one was supposed to witness him tonight. He’s done being seen and perceived. You hear him? Done!

“Is that…so.” The guy squints at him. Kravitz would be assuming what the fuck he’s judging Kravitz on, but he kind of got lost in the attractive freckles and his long elegant fingers, and the gap in his teeth. And the hair, despite the fact that it is still all over the place, isn’t a minus. “I am Taako, prince of the elves.” 

“Oh, okay, and we’re back to zero,” Kravitz says, cheerfully realizing he’s going to have to fucking call 911 because he truly cannot figure out what the better option is. Except. He’s going to get strangled in his fucking Death Note t-shirt from 2013 because his goddamn Jack Skellington pants don’t have pockets and his phone is in the kitchen, actually, and they may not put that in his eulogy but everyone is going to know anyway, because of cringe osmosis. 

He doesn’t usually believe in cringe. Funny what imminent death does to your philosophy. 

“Why is that?” Taako squints at him, tucking hair behind his ears. And, shit, maybe he’s done costume work for whatever the fuck this is, maybe he’s had some insane plastic surgery, but his ears truly are crazy pointy. Not even elf in a movie pointy, like ten, twelve inches long, and they flick when Taako touches them. Kravitz reorients some facts, none of which add up, and he struggles.

“I’m Kravitz,” he says, against both his good judgement and his judgement he uses when his good judgement is dirty. 

Taako squints at him harder. Kravitz wonders if he should put the lamp down, especially considering it knocked over his wifi router which is blinking frantically like some kind of crying electric beast, but honestly whatever at this point. Like, is he going to die? Shit, then at least he doesn’t have to work tomorrow, you know? Sorry mama, he promises he cares, mostly. 

“Assistant head of sales,” he adds. Taako considers this at length. 

“I think I took the wrong portal,” he decides. He turns back to the closet, which reveals that he has a tail, actually, for real, as far as Kravitz can gather, and puts his hands on his enticing hips in frustration when he finds Kravitz’s bullshit mess of Work clothes, Dress Up clothes, Play clothes, and Nobody Can See Me Fuck Off clothes. And also four wigs, his heated blanket, the printer he’s mad at, an embarrassing amount of hangers,  and two paper boxes full of dumb garbage he can’t let go of from two moves ago. And some glitter. Shut up is why. 

"What the fuck is going on?" Kravitz demands. 

"Well," Taako says, with deep conviction, and doesn't finish. He turns back to face Kravitz. That tail flicks dismissively, still somehow incredibly appearing to be legitimate. Kravitz eyes him over, takes in his elaborate and scrumbled suit-gown of purple and gold gossamer and his thighs high boots and his golden eye makeup and also the way he keeps glancing at Kravitz's pajama pants. 

"Well?" Kravitz prompts. "You realize you're in Austin, Texas?" 

"Nah, uh," Taako looks a little pale now. "Chaboi was in Phandolin, in uh, Faerun, the fuck is a Texas?" 

So true. 

"Don't you dare tell me you hopped through a portal in my closet like reverse Narnia." 

"Narnia?" 

Man. Maybe Kravitz will hit him with the lamp. Shame he's so pretty. 

"I don't have time for this," he mutters. "You always watch those fantasy movies and they just handle it, but I don't have- what am I supposed to do, call in an elf prince personal day? If I'm going to take an elf prince personal day you can bet- sorry, I…" Kravitz winces. Just because he wants this to be fake doesn't mean there isn't a situation at hand. 

"I mean, Taako is all for an elf prince personal day if it means what I think it means." Taako grins, showing surprisingly sharp teeth, which Kravitz feels totally regular about, no details thanks. "I was running from some assholes who wanted to murder me. I mean, I don't necessarily think monarchy is the way of the future either, but you don't see me assassing about it." 

"Well, no monarchy here." Kravitz can't help but be glib. He finally puts the stupid lamp down. Just on the bed. No way he's sleeping anytime soon. This makes the cord pull taut. His sad router just slumps onto the floor. Taako jumps and inspects its flashing lights, alarmed but also kind of fascinated. 

"No?" He glances at Kravitz, and back at the lights. "Sick. That sounds easier."

"Well, it's not like there's no- we don't have to do politics. Hey, Taako, if I take this as nonfiction, which I am not committed to, and do not faint, which I am also not committed to, what the fuck am I meant to do next?"

"I mean either we take that elf prince personal day, really make it count, or uh, you magic me back home, mister?" 

"Magic isn't real!" Kravitz runs his hands down his face, excruciatingly aware of the comedy of the situation. 

"Ah," Taako says, really tasting the gravity here. "Guess there's no option but to fuck me." 

"Now hang on," Kravitz says, struggling not to laugh. 

"No, I'm right, probably." 

[real-total-drama-takes]

Cody Emmet Jameson Anderson, your aura hurts to be in the same multiverse as. I feel debased just knowing that you exist. I despise everything about you, and I wish you would go away. You are jetsam who dreams of becoming flotsam. You won't make it. I beg for sweet death to come and remove me from a world which became unbearable when you crawled out of a harpy's lair. It is hard to believe how incredibly stupid you are. Stupid as a stone that the other stones make fun of. So stupid that you have traveled far beyond stupid as we know it and into a new dimension of stupid. Meta-stupid. Stupid cubed. Trans-stupid stupid. Stupid collapsed to a singularity where even the stupons have collapsed into stuponium. Stupid so dense that no intelligence can escape. Singularity stupid. Blazing hot summer day on Mercury stupid. You emit more stupid in one minute than our entire galaxy emits in a year. Quasar stupid. It cannot be possible that anything in our universe can really be this stupid. This is a primordial fragment from the original big stupid bang. A pure extract of stupid with absolute stupid purity. Stupid beyond the laws of nature. I must apologize. I can't go on. This is my epiphany of stupid. After this experience, you may not hear from me for a while. I don't think that I can summon the strength left to mock your moronic opinions and malformed comments about boring trivia or your other drivel. Duh. The only thing worse than your logic is your manners.P.S.: You are hypocritical, greedy, violent, malevolent, vengeful, cowardly, deadly, mendacious, meretricious, loathsome, despicable, belligerent, opportunistic, barratrous, contemptible, criminal, fascistic, bigoted, racist, sexist, avaricious, tasteless, idiotic, brain-damaged, imbecilic, insane, arrogant, deceitful, demented, lame, self-righteous, byzantine, conspiratorial, fraudulent, libelous, bilious, splenetic, spastic, ignorant, clueless, EDLINoid, illegitimate, harmful, destructive, dumb, evasive, double-talking, devious, revisionist, narrow, manipulative, paternalistic, fundamentalist, dogmatic, idolatrous, unethical, cultic, diseased, suppressive, controlling, restrictive, malignant, deceptive, dim, crazy, weird, dyspeptic, stifling, uncaring, plantigrade, grim, unsympathetic, jargon-spouting, censorious, secretive, aggressive, mind-numbing, arassive, poisonous, flagrant, self-destructive, abusive, puerile and a Stupid Spoon Incelic Harry Styles.

𓂸

[dickgoblinpi]

so i havent been very active on tumblr lately and i dont know how many of my followers are still actually here or who is likely to see this, but its worth a shot

my beautiful baby boy Alice has an aggressive malignant tumour in his mouth. diagnostics and medication so far have cost around £1500 which has meant draining my bank account and maxing out my credit. i need to drum up another £1000 at least to be able to pay for his lump removal op on Monday

these tumours are usually painful and because it is right by his teeth, he is often bumping and scraping it which causes bleeds and secondary infections. it needs to Go to make him more comfortable and to give us the best shot of shrinking and slowing the remaining cancer cells so we can, with a bit of luck, have another couple of happy years together before we have to say goodbye

he is my oldest friend, an absolute angel of love and joy, and apart from this stinking cancer he is fit and well and full of life. if anyone is able to help me give him the best chance of putting this disease at bay to enjoy his golden years to the fullest, it would mean the world

if you cant spare anything, please do share widely. he's not ready to go just yet

thank you

[bryce-hansen-hfjone]

how DARE you h8 skibidi toilet........

L + ratio + wrong + get a job + unfunny + you fell off + never liked you anyway + cope + ur allergic to gluten + don't care + cringe ur a kid + literally shut the fuck up + galileo did it better + your avi was made in MS Excel + ur bf is kinda ugly + i have more subscribers + owned + ur a toddler + reverse double take back + u sleep in a different bedroom from your wife + get rekt + i said it better + u smell + copy + who asked + dead game + seethe + ur a coward + stay mad + you main yuumi + aired + you drive a fiat 500 + the hood watches xqc now + yo mama + ok + currently listening to rizzle kicks without u. plus ur mind numbingly stupid plus ur voice is ronald mcdonald + dont care + didnt ask + cry about it + stay mad + get real + L + mald seethe cope harder + h0es mad + basic + skill issue + ratio + you fell off + the audacity + triggered + any askers + redpilled + get a life + ok and? + cringe + touch grass + donowalled + not based + your’re probably white + not funny didn’t laugh + you’re* + grammar issue + go outside + get good + reported + ad hominem + GG! + ur momdon’t care + didn’t ask + cry about it + stay mad + get real + L + mald seethe cope harder + hoes mad + basic + skill issue + ratio + you fell off + the audacity + triggered + any askers + redpilled + get a life + ok and? + cringe + touch grass + donowalled + not based + your’re a full time discordian + not funny didn’t laugh + you’re* + grammar issue + go outside + get good + your gay + reported + ad hominem + GG! + ur mom + unknown + random + biased + racially motivated + kys + ur unfunny +ratio don’t care + didn’t ask + cry about it + stay mad + get real + L + mald seethe copedon’t care + didn’t ask + cry about it + stay mad + get real + L + mald seethe cope harder + h0es mad + basic + skill issue + ratio + you fell off + the audacity + triggered + any askers + redpilled + get a life + ok and? + cringe + touch grass + donowalled + not based + your’re probably white + not funny didn’t laugh + you’re* + grammar issue + go outside + get good + reported + ad hominem + GG! + ur momdon’t care + didn’t ask + cry about it + stay mad + get real + L + mald seethe cope harder + hoes mad + basic + skill issue + ratio + you fell off + the audacity + triggered + any askers + redpilled + get a life + ok and? + cringe + touch grass + donowalled + not based + your’re a full time Discordian + not funny didn’t laugh + you’re* + grammar issue + go outside + get good + your gay + reported + ad hominem + GG! + ur mom + unknown + random + biased + racially motivated + kys + ur unfunny +ratio don’t care + didn’t ask + cry about it + stay mad + get real + so bad + so ass + fucking kill yourself loser + I did both of your parents + you're stupid + you are a rock + you lost your mewing streak + your parents don't love you at all + I fucked them again + you're like 5 bro get off the internet idiot. + you aren't sigma, or male, or a rizzler. You aren't even a LITTLE RIZZLER. + You don't main + level 0 gyatt + no bitches + no balls

/NOT SATIRE

/srs

oh yeah? You are hypocritical, greedy, violent, malevolent, vengeful, cowardly, deadly, mendacious, meretricious, loathsome, despicable, belligerent, opportunistic, barratrous, contemptible, criminal, fascistic, bigoted, racist, sexist, avaricious, tasteless, idiotic, brain-damaged, imbecilic, insane, arrogant, deceitful, demented, lame, self-righteous, byzantine, conspiratorial, satanic, fraudulent, libellous, bilious, splenetic, spastic, ignorant, clueless, illegitimate, harmful, destructive, dumb, evasive, double-talking, devious, revisionist, narrow, manipulative, paternalistic, fundamentalist, dogmatic, idolatrous, unethical, cultic, diseased, suppressive, controlling, restrictive, malignant, deceptive, dim, crazy, weird, dystrophic, stifling, uncaring, plantigrade, grim, unsympathetic, jargon-spouting, censorious, secretive, aggressive, mind-numbing, abrasive, poisonous, flagrant, self-destructive, abusive, and socially-retarded.

[pb-dot]

Film Friday: [REC]

After talking about Paranorman last week I feel a hankering for some more in the world of the spooky, and so I figured it was time to talk about one of my favorite scary movies, certainly the one that has the best track record at scaring the utter bejeezus out of me, the Spanish found footage film [REC]

TV Journalist Angela Vidal and her trusty cameraman Pablo are filming a Human Interest story about the life of firemen on night watch when the emergency services are called to assist an old woman who has fallen in her home. Hoping for a slight touch of action to the otherwise painfully boring footage, Angela and Pablo tag along to the apartment complex where the rest of the movie takes place. Unfortunately for them, by the time they get there the old woman is dead, the exit is sealed by the government shortly after their arrival, and to make it all worse said old woman refuses to actually stay dead.

Now, Found Footage is an oft-maligned subgenre, and I will concede that many of its criticisms are valid. Shaky camera and characters too scared and cinema verite-incoherent to explain what the hell is going on can wallpaper over subpar effects and incoherent writing and the by now beyond cliche ending of whatever beastie is out hunting amateur filmmakers or journalists lunging at the cameraman isn't as satisfying as the first five or so times we saw that. Still. [REC] makes it work, and I think there are a couple of reasons for it.

First of all, the main characters are professionals. Pablo wields a heavier, more stable camera than the handheld camcorders that are often the POV in these things, and his skills and experience compels him to keep striving to keep a more or less readable picture until shit has well and truly hit the fan. Similarly, Angela's journalistic instincts wake up in a big way under the unusual threat and the mad scramble to get to safety as the firefighters and tenants fall to the intensely aggressive rabies-like disease that makes them turn on their fellows. Her ongoing narration and commentary on their situation also help bridge gaps in the narrative and provide a small, but important jolt of characterization. Her attitude also does a good job of justifying the movie going on. When all is said and done, she is a journalist, and what's going on with her may be terrifying, but it is also capital N-News. As she herself says close to the movie's final crisis point "We have to tape everything, Pablo, for fuck's sake."

Perhaps the best part about [REC] is how perfect the movie's sense of timing is and how it capitalizes on the verisimilitude offered by the camera pov style. Sudden jumpscares do not come in the form of cinematic build up and scare stings but in the middle of an otherwise normal-ass scene where something unexpected and frightening will happen at a point where your mind has kind of assumed this scene's just a breather scene or is secretly delivering you some exposition when WHAM!

My favorite of these scares is just so insidiously effective that it has gotten me every single time I've watched the movie. The scene in question where our heroes use their camera, now the only light they have access to, to scout out a potential escape. Despite knowing the type of scene before I even saw it and expecting a scare to come out of left field either before or after I expect it, the scare still hits me like a damn train. It could be that the filmmakers hold back, almost to the degree where you end up wondering if it's misdirection and that the real scare will be when the camera is pulled back when WHAM, you get got by the simplest conceptual scare possible, there's something scary and grody-looking in your attic and it fucking GETS you.

REC isn't one of those movies that I have zero complaints about, there's a kind of out-of-left-field twist to what exactly is going on that feels more like sequel bait than part of a cohesive story. There are also perhaps more moving parts to this apartment building than feels entirely plausible and one or two scenes that don't quite hit the mark. These are minor quibbles hanging on for dear life on a majestic shadow-beast of a movie. Normally I don't even like fast zombies all that much, but these living dead folks got my adrenaline going like there are ambush predators about, and make no mistake.

[gargarismo-blog1]

Letallis - A Thousand And One Nights - Chapter 1

aking musical influence from OPETH, GOJIRA, THE BLACK DAHLIA MURDER, and conceptually based around the Arabian Nights tales, A Thousand And One Nights - Chapter 1 is the first of three upcoming EP releases. 

The band comments: 

"This music has been crafted to take you along the ride of the classic literary stories that transcend time. Filled with peaks, valleys, intimate moments and aggressive passages, each song is made to take the listener along the journey."

More on A Thousand And One Nights - Chapter 1: "Merchant": "This story begins with the listener journeying to a bazaar who encounters a mysterious merchant. The merchant entices the wanderer to read the tales that will eventually become A Thousand And One Nights."

"A Thousand And One Nights": "This is the first “frame” story to the ATAON. Telling the tale of a King who is betrayed by his wife. Consumed by hatred, he has her killed, and decides he will take a new, virgin wife every night. Sleeping with them for the night, and having them killed the next day to ensure he can’t be betrayed again. 

After several years of killing off nearly all the women virgins in his kingdom, his head vizier’s daughter offers herself to the king. She devises a plan; telling him such intriguing stories every night, yet not entirely finishing them, so that he becomes so captivated as to spare her life the next day. This goes on repeatedly for a thousand and one nights, until finally he spares her life permanently and they marry (Ouch. Happy ending much?) Overall a tale about a brave heroin figure who gives herself over to stop a merciless King."

"Thief": "Thief is based around the point of view of a street thief who will stop at nothing, burn any bridge, to get what he wants. Honor below all. He eventually has an encounter with a jinni, asking him to satisfy his endless greed. Overall about a person with insatiable hunger for anything he doesn’t already possess."

"The Vizier And The Sage": "This story is about a king who is stricken with leprosy. A man who has everything he could want in life, except his physical appearance. One day the king is approached by a sage who says he can cure him of his disease. The King, initially trusting the sage, takes him in and grants him many treasures. The Kings vizier, a very ill intentioned manipulator, convinces the king the sage cannot be trusted. 

The king eventually has the sage beheaded. But before his head is removed, he tells the king he has one last gift. After his beheading, place the sages head on a plate and he will instruct him. The king, instructed to read from a book by the now only head, flips through the pages, only to find them poisoned and is killed by the sage. The sages head proceeds to speak of how if the king hadn’t been manipulated by hate, he would still be alive. Overall a story of how many people already have all they need in life, if they only look for it. And to not be coerced by hateful opinions of others." About LETALLIS: Formed by Jake Calonius in New Jersey in 2006, the band released their first full-length The World Awakened, shortly after. the band soon took to the live stage opening up for bands like CANDLEMASS, DAYLIGHT DIES and POWERMAN 5000, as well as landing a spot at the NJ date of Warped Tour in 2008. Relocating to New York City in 2009, 2014 saw the release of Resonate. After joining forces with new drummer Alex Cohen (MALIGNANCY) and other members to play live, the band started gigging around NYC in 2017 and dove into the local metal scene. A Thousand And One Nights - Chapter 1, is the first EP in a series of three releases. LETALLIS is: 

Jake Calonius (Guitar/Vocals) Marcus Hedwig (Guitar) Alex Cohen (Drums) Credits:  All music written/recorded/mixed and mastered by Jake Calonius in Brooklyn, NY.  Lyrics by Jake Calonius.  Artwork by Carl Ellis.  ATAON calligraphy by Muhammed Basdag. "A Thousand And One Nights" pre-save link: https://show.co/0NENz4u

[redsn0w]

Asura Rot, a rare and highly malignant affliction, manifests as a progressive degenerative condition with devastating effects on the afflicted individual's psyche and physiology. It is characterized by a twisted pathophysiological phenomenon, wherein the victim undergoes a rapid transformation into a psychopathic state unless they fulfill the morbid requirement of taking the lives of a thousand individuals.

Initial Stages:

Hair Discoloration: The earliest observable symptom of Asura Rot is the discoloration of the victim's hair, transforming from its original hue to an ashen white. This striking change is believed to be a result of altered melanin production within the hair follicles, indicative of the profound disturbances occurring at a cellular level.

Cardiac Paradox: As the disease progresses, a paradoxical phenomenon manifests within the victim's cardiovascular system. Although the heart ceases its regular rhythm and exhibits no discernible beats, it continues to sustain the individual's existence. This peculiar state challenges conventional understanding of vital organ function and necessitates further investigation into the mechanisms underlying the anomaly.

Neurological Deterioration: Neurological changes become evident during the early stages of Asura Rot. Afflicted individuals display signs of escalating aggression, erratic behavior, and an insatiable craving for violence. This progressive alteration in the neural pathways disrupts cognitive processing, leading to the loss of empathy, moral reasoning, and impulse control.

Heightened Sensory Perception: Paradoxically, alongside the cognitive decline, victims experience heightened sensory perception. Their senses become acutely attuned to stimuli, enabling them to track potential victims with an uncanny precision. This enhanced sensory awareness is a disturbing aspect of the disease, serving as a catalyst for the insatiable bloodlust that afflicts them.

Enhanced Regenerative Abilities: Another remarkable aspect of Asura Rot is the rapid extreme regenerative capacity exhibited by the afflicted individuals. Wounds that would be fatal to an unaffected person heal at a highly accelerated rate, resulting in a swift recovery from injuries sustained during acts of violence. This regenerative ability is suspected to contribute to the prolonged survival of individuals suffering from this affliction.

[medicineforcare]

Belustine Capsules

Belustine 40mg Capsule is an anticancer medicine. It is used in the treatment of different kinds of cancers such as brain tumor, lung cancer, Hodgkin’s disease, and malignant melanoma. It may also used to treat other conditions, as determined by the doctor.

When taking Belustine 40 Capsule, it is best to take it first thing in the morning, if possible. Your doctor will determine the appropriate dosage and how frequently you should take it. This may vary over time depending on the condition you are being treated for. It is important that you follow your doctor's instructions exactly. If taken improperly or in excess, it might have extremely harmful negative effects. You might not notice or feel the effects of the medication for a few weeks or months, but unless your doctor instructs you otherwise, keep taking it. 

The most frequent adverse effect of this medication is a reduction in your body's white blood cell count. In addition, it may result in other negative effects like hair loss, nausea, and vomiting. Throughout this medication's course, routine blood tests are necessary to monitor your kidney, liver, and heart functions in addition to your blood cells. Notify your physician if you experience any unusual bleeding or bruises, or if you see symptoms of an infection, such as fever, chills, or body aches. 

Inform your doctor before using it if you have kidney or liver issues, or if you are currently taking any medications for infections. Inform your doctor about all of the medications you take because this prescription may interact with or be affected by many other medications. It is not advised to use this medication while nursing or when pregnant. To prevent conception during therapy, it is crucial for both males and females to utilize an effective form of contraception.

Benefits of Belustine Capsule

In Brain tumor

A brain tumor is an aberrant mass or grouping of cells, either benign or malignant in nature. Belustine 40 Capsule inhibits the growth and/or destroys cancer cells while also preventing their replication. You should go over the advantages and disadvantages of this strong, highly poisonous medication with your physician. While undergoing this treatment, you should abstain from alcohol use and stay hydrated by drinking lots of water. 

In Lung cancer

The malignant cells in the lungs are eliminated by Belustine 40 Capsule, which also prevents their growth and spread. However, because it lowers immunity, stay away from crowds and wash your hands frequently to avoid getting sick. Unless the doctor instructs you otherwise, drink lots of fluids. To receive the full benefits of the medication, maintain a balanced diet and take it as directed.

In Hodgkin’s disease

One kind of lymphoma, a blood cancer that originates in the lymphatic system, is Hodgkin's disease. The immune system fights infections and eliminates waste with the aid of the lymphatic system. Belustine 40 Capsule inhibits the growth and/or destroys cancer cells while also preventing their replication. Take it as directed and pay close attention to your doctor's recommendations.

In Malignant melanoma

One kind of skin cancer that appears in melanocytes—the cells that make the pigment known as melanin—is called malignant melanoma. The pigment that gives skin its color is called melanin. Skin cancer that is most aggressive and lethal is called malignant melanoma. Belustine 40 Capsule destroys cancer cells by attaching themselves to their DNA, or genetic code. It also stops them from spreading and growing. This aids in the cancer treatment.

[jdrsandeep]

Esophageal Cancer Awareness – Abdominal Cancer Day

Esophageal cancer is a serious and often life-threatening condition that affects the esophagus, the tube that carries food from the throat to the stomach. It ranks among the more aggressive forms of cancer, often remaining asymptomatic until reaching advanced stages, which makes early detection and awareness crucial. As part of Abdominal Cancer Day’s mission, we seek to raise awareness about esophageal cancer, promote early diagnosis, and support individuals and families impacted by this disease.

Understanding Esophageal Cancer

Esophageal cancer occurs when malignant cells form in the tissues of the esophagus. There are two main types of esophageal cancer: squamous cell carcinoma and adenocarcinoma. Squamous cell carcinoma develops in the flat cells lining the esophagus, while adenocarcinoma arises from glandular cells, often in the lower part of the esophagus.

Several risk factors contribute to the development of esophageal cancer, including:

Smoking and alcohol consumption: These habits can damage the esophagus's lining and increase the likelihood of cancerous growths.

Chronic acid reflux: Known as gastroesophageal reflux disease (GERD), this condition can irritate the lining of the esophagus and lead to Barrett's esophagus, a precancerous change.

Obesity: Excess body weight can increase pressure on the stomach, worsening acid reflux and raising the risk of esophageal cancer.

Dietary factors: Diets low in fruits and vegetables and high in processed foods and red meat have been linked to esophageal cancer.

Signs and Symptoms

The early stages of esophageal cancer often present without noticeable symptoms. However, as the cancer progresses, individuals may experience the following:

Difficulty swallowing (dysphagia)

Unexplained weight loss

Persistent chest pain or discomfort

Hoarseness or chronic cough

Indigestion or heartburn that doesn’t improve with treatment

Vomiting or coughing up blood

These symptoms may not always indicate cancer but should be evaluated by a healthcare professional, especially if they persist.

Importance of Early Detection

Early detection of esophageal cancer significantly improves treatment outcomes and survival rates. Unfortunately, because symptoms often appear later in the disease, many cases are diagnosed at advanced stages. That’s why awareness and screening are key components of the fight against esophageal cancer.

For individuals with risk factors such as chronic GERD or Barrett's esophagus, regular screening tests like endoscopy may help detect abnormal changes in the esophagus before they develop into cancer. Additionally, promoting a healthy lifestyle that includes quitting smoking, reducing alcohol consumption, maintaining a healthy weight, and eating a balanced diet rich in fruits and vegetables can lower the risk of esophageal cancer.

Treatment Options

Treatment for esophageal cancer varies depending on the stage and type of cancer. Common treatment options include:

Surgery: Removal of part or all of the esophagus may be necessary for localized cancer.

Chemotherapy and radiation therapy: These treatments are often used to shrink tumors before surgery or to treat more advanced cancer.

Targeted therapy: This approach targets specific proteins or mutations in cancer cells, sparing normal cells and reducing side effects.

Immunotherapy: This emerging treatment helps the immune system recognize and attack cancer cells.

Each treatment plan is tailored to the individual’s condition, often involving a combination of these therapies.

Abdominal Cancer Day's Commitment

At Abdominal Cancer Day, we are committed to supporting research, awareness, and patient advocacy for all forms of abdominal cancer, including esophageal cancer. Through educational campaigns, community events, and resources for patients and their families, we aim to improve awareness and understanding of this disease.

 We also promote early detection and encourage individuals to seek regular medical checkups, especially if they are at higher risk.

Together, we can make a difference in the fight against esophageal cancer. By spreading awareness, supporting research, and advocating for early detection, Abdominal Cancer Day hopes to reduce the impact of this devastating disease and improve the lives of those affected.

If you or someone you know is experiencing symptoms related to esophageal cancer or has risk factors, it’s important to consult with a healthcare professional for appropriate screening and care. For more information and resources, visit our website or participate in our events. Your health matters, and Abdominal Cancer Day is here to support you every step of the way.

Read More Info : stomach cancer

pancreatic cancer

[credenceresearchdotblog]

The HER2 gastric cancer market is set for a steady ascent from 2024 to 2032, with a compound annual growth rate (CAGR) of 3.12%. The market’s size in 2024 is 1340.56 million USD, and it’s projected to escalate to 1714.07 million USD by 2032. Gastric cancer, a prevalent and often fatal malignancy, continues to pose a significant global health challenge. Among its various subtypes, HER2-positive gastric cancer has garnered considerable attention due to its distinct biological characteristics and therapeutic implications. HER2, or Human Epidermal Growth Factor Receptor 2, is a protein that promotes cell growth, and its overexpression in gastric cancer cells is associated with aggressive disease progression and poor prognosis. The HER2 gastric cancer market has evolved rapidly in recent years, driven by advancements in targeted therapies and personalized medicine, offering hope for improved patient outcomes.

Browse the full report at https://www.credenceresearch.com/report/her2-gastric-cancer-market

Market Dynamics

The HER2 gastric cancer market is shaped by a complex interplay of factors, including the rising incidence of gastric cancer, advances in diagnostic technologies, the development of targeted therapies, and growing awareness of personalized treatment approaches. According to the World Health Organization (WHO), gastric cancer is the fifth most common cancer worldwide, with over a million new cases diagnosed annually. Although HER2-positive gastric cancer represents only about 10-20% of these cases, the need for specialized treatments has spurred significant market growth.

Advancements in Diagnostics and Treatment

One of the key drivers of the HER2 gastric cancer market is the improvement in diagnostic capabilities. The introduction of more accurate and accessible testing methods, such as immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), has facilitated the identification of HER2-positive patients. Early and precise detection is crucial, as it allows for the timely initiation of targeted therapies, which can significantly improve survival rates.

The development of targeted therapies has revolutionized the treatment landscape for HER2-positive gastric cancer. Trastuzumab (Herceptin), the first HER2-targeted therapy approved for gastric cancer, has been a game-changer, improving overall survival in combination with chemotherapy. The success of Trastuzumab has paved the way for the development of other HER2-targeted agents, including pertuzumab, trastuzumab deruxtecan, and tucatinib, each offering different mechanisms of action and potential benefits.

Challenges and Opportunities

Despite these advancements, the HER2 gastric cancer market faces several challenges. One of the primary obstacles is the development of resistance to HER2-targeted therapies. Many patients eventually progress despite initial treatment success, necessitating the exploration of combination therapies and novel treatment strategies. Additionally, the high cost of targeted therapies can limit access, particularly in low- and middle-income countries, where the burden of gastric cancer is often highest.

However, these challenges also present opportunities for innovation. The ongoing research into overcoming resistance mechanisms has led to the investigation of new drug combinations and next-generation HER2 inhibitors. Furthermore, the integration of biomarker testing into routine clinical practice has the potential to refine patient selection and optimize treatment outcomes, ensuring that the right patients receive the most effective therapies.

Regional Market Insights

The HER2 gastric cancer market exhibits regional variations, reflecting differences in gastric cancer incidence, healthcare infrastructure, and access to advanced treatments. Asia-Pacific, particularly East Asia, represents the largest market due to the high prevalence of gastric cancer in countries like Japan, South Korea, and China. In contrast, North America and Europe have smaller patient populations but benefit from robust healthcare systems and greater access to innovative therapies.

In Asia-Pacific, the market is expected to grow rapidly due to increasing awareness, improved diagnostic capabilities, and the introduction of new targeted therapies. Governments in the region are also investing in cancer care infrastructure, which is likely to further boost market growth. Meanwhile, in North America and Europe, the focus is on expanding the use of combination therapies and overcoming treatment resistance, with ongoing clinical trials playing a pivotal role in shaping the future treatment landscape.

Future Outlook

The HER2 gastric cancer market is poised for continued growth as new therapies and diagnostic tools are developed and integrated into clinical practice. The trend towards personalized medicine, where treatments are tailored to the individual patient based on genetic and molecular profiling, is expected to drive innovation and improve outcomes for HER2-positive gastric cancer patients. Moreover, the increasing emphasis on combination therapies, addressing resistance mechanisms, and expanding access to targeted treatments in emerging markets will be crucial in shaping the future of this dynamic market.

Key Player Analysis:

Roche (Herceptin)

Merck (Keytruda)

AstraZeneca (Tagrisso)

Daiichi Sankyo (Enhertu)

Bristol Myers Squibb (Opdivo)

Genentech

MacroGenics

Seattle Genetics

Pfizer

Takeda

Segmentations:

By Therapy:

Chemotherapy

Immunotherapy

Radiation Therapy

Targeted Therapy

By Stage:

Stage I

Stage II

Stage III

Stage IV

By End-User:

Ambulatory surgery centers,

Hospitals and Specialty clinics

Others

Based on the Geography:

North America

US

Canada

Mexico

Europe

Germany

France

UK

Italy

Spain

Rest of Europe

Asia Pacific

China

Japan

India

South Korea

South-east Asia

Rest of Asia Pacific

Latin America

Brazil

Argentina

Rest of Latin America

Middle East & Africa

GCC Countries

South Africa

Rest of Middle East and Africa

Browse the full report at https://www.credenceresearch.com/report/her2-gastric-cancer-market

About Us:

Credence Research is committed to employee well-being and productivity. Following the COVID-19 pandemic, we have implemented a permanent work-from-home policy for all employees.

Contact:

Credence Research

Please contact us at +91 6232 49 3207

Email: sales@credenceresearch.com

Website: www.credenceresearch.com

[drkamath]

Best Skin Cancer Treatment at Dr. Anil Kamath in Banashankari

Understanding Skin Cancer

Skin cancer occurs when abnormal cells in the skin grow uncontrollably, forming malignant tumors. The most common types of skin cancer include basal cell carcinoma, squamous cell carcinoma, and melanoma, with melanoma being the most aggressive form. Factors such as prolonged exposure to ultraviolet (UV) radiation, fair skin, a history of sunburns, and a family history of skin cancer can increase the risk of developing the disease.

Early detection of skin cancer significantly improves the chances of successful treatment. Regular skin checks and awareness of changes in moles or skin lesions are critical in catching skin cancer in its early stages.

Why Choose Dr. Anil Kamath for Skin Cancer Treatment?

Dr. Anil Kamath is a renowned oncologist with extensive experience in treating various types of cancer, including skin cancer. His practice in Banashankari, Bangalore, is known for providing comprehensive, patient-centered care that is tailored to each individual’s unique needs.

Dr. Kamath’s approach to skin cancer treatment is characterized by a meticulous attention to detail, ensuring that every aspect of the patient’s condition is thoroughly evaluated. His expertise in the field, combined with a commitment to staying abreast of the latest advancements in oncology, makes him one of the top choices for skin cancer treatment in Bangalore.

Comprehensive Diagnostic Services

Accurate diagnosis is the first step in effective skin cancer treatment. Dr. Kamath’s clinic in Banashankari is equipped with state-of-the-art diagnostic tools that enable precise evaluation of skin lesions. Services include dermoscopy, skin biopsies, and advanced imaging techniques that help in determining the extent and type of skin cancer.

Dr. Kamath places a strong emphasis on early detection, and he encourages regular skin checks for patients at risk of developing skin cancer. His diagnostic approach is thorough, ensuring that no detail is overlooked, which is crucial for planning the most effective treatment strategy.

Personalized Treatment Plans

Every case of skin cancer is unique, and Dr. Kamath develops personalized treatment plans that are tailored to each patient’s specific condition. Depending on the type, stage, and location of the skin cancer, treatment options may include surgical excision, Mohs surgery, radiation therapy, chemotherapy, or targeted therapy.

Dr. Kamath is skilled in a variety of surgical techniques, including minimally invasive procedures that aim to remove cancerous tissue while preserving as much healthy skin as possible. For more advanced cases, he collaborates with a multidisciplinary team of specialists to provide comprehensive care that addresses all aspects of the patient’s health.

Advanced Treatment Techniques

Dr. Kamath’s clinic utilizes the latest advancements in skin cancer treatment, ensuring that patients have access to the most effective and least invasive options available. Techniques such as Mohs surgery, which is highly effective for treating certain types of skin cancer with minimal scarring, are part of the clinic’s offerings. Additionally, Dr. Kamath is experienced in using targeted therapies and immunotherapies that are tailored to treat specific types of skin cancer, particularly melanoma.

Compassionate Patient Care

Beyond his clinical expertise, Dr. Anil Kamath is known for his compassionate approach to patient care. He understands that a skin cancer diagnosis can be a source of significant anxiety, and he takes the time to educate his patients about their condition and the treatment options available. Dr. Kamath believes in empowering his patients with knowledge, which helps alleviate fears and allows for informed decision-making.

Patients under Dr. Kamath’s care benefit from his empathetic communication style and the supportive environment he creates at his clinic. His dedication to patient well-being extends beyond treatment, as he also focuses on preventive care and long-term follow-up to monitor for any signs of recurrence.

Conclusion

If you or a loved one is facing a skin cancer diagnosis, seeking expert care is essential for the best outcomes. Dr. Anil Kamath in Banashankari, Bangalore, offers top-tier skin cancer treatment that combines medical excellence with compassionate care. His comprehensive diagnostic services, personalized treatment plans, and advanced techniques ensure that each patient receives the highest standard of care tailored to their specific needs.

[thyroidsurgeryuae-blog]

Understanding Parathyroid Disease: Symptoms, Diagnosis, and Treatment Options

Thyroid cancer is an increasingly prevalent health issue in the Middle East, reflecting both regional Thyroid Cancer Middle East advancements and changing epidemiological patterns. The thyroid gland, located at the base of the neck, plays a vital role in metabolism regulation through hormone production. When malignant cells form in this gland, it leads to thyroid cancer, which can be categorized into several types: papillary, follicular, medullary, and anaplastic thyroid cancer.

Papillary thyroid cancer is the most common and generally the most treatable form, while anaplastic thyroid cancer is rare but highly aggressive. The rising incidence of thyroid cancer in the Middle East can be attributed to several factors, including improved diagnostic capabilities, increased awareness, and possibly environmental and genetic factors unique to the region.

The availability of advanced diagnostic tools such as high-resolution ultrasound and fine-needle aspiration biopsy has significantly contributed to early detection and diagnosis. These tools allow healthcare professionals to identify and evaluate thyroid nodules more effectively, leading to earlier and more accurate diagnoses.

In the Middle East, there is also a growing emphasis on public health initiatives aimed at increasing awareness about thyroid cancer. Educational campaigns stress the importance of regular check-ups and early detection, which are crucial for effective treatment. Additionally, access to Best Thyroid Center UAE specialized care and improved medical infrastructure has enhanced treatment outcomes.

Environmental factors, such as dietary iodine intake, have also been linked to thyroid health. In some parts of the Middle East, variations in iodine consumption due to dietary habits may influence the prevalence of thyroid disorders, including cancer. Genetic predispositions, influenced by the region’s demographic and hereditary patterns, are another area of ongoing research.

Treatment for thyroid cancer typically involves a combination of surgery, radioactive iodine therapy, and hormone replacement therapy. The success rates are generally high, especially for the more common and less aggressive forms of the disease. However, continuous monitoring and follow-up care are essential to manage potential recurrences and long-term health outcomes.

In conclusion, Thyroid Cancer Middle East is a growing concern, but advancements in medical diagnostics, increased awareness, and improved healthcare infrastructure are contributing to better outcomes for patients. Ongoing research into the unique environmental and genetic factors in the region will further aid in understanding and combating this disease.