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[unifiedcitationjournals]

Global Research Journal of Pharmaceutical and Drug Discovery [GRJPDD]

 Introduction:

In order to give unlimited access to the domains of pharmacy and pharmaceuticals, the Global Publication of Pharmaceuticals is being produced as an international peer-reviewed journal. The way the pharmaceutical sciences respond with appropriate remedies, such as diagnosis, surgical, medicinal, and rehabilitation methods, is crucial to the efficient management of public health challenges.

Hospital and Clinical Pharmacy, Pharma Research & Review, Pharmaceutical Quality Assurance, Pharmaceuticals and Nanotechnology, Pharmacognosy and Phytochemistry, and Toxicology are all topics covered in the Pharmaceutical Journals of Research and Review International.

Journal of Pharmacy & Pharmaceuticals replaced Journal of Pharmaceutical Science and Drug Designing as the journal's name. Leading articles, meeting reports, insightful observations, correspondence, and book reviews pertaining to pharmaceutical sciences (Pharmacy, Pharmacognosy, Pharmaceuticals, Pharmacokinetics, Pharmaceutical Analysis,Pharmacy Practice), among others, are accepted.

Journal of Pharmacy & Pharmaceutic Global Journal of Pharmaceuticals adheres to the Scholars Open Access Publishing Policies and the Creative Commons Attribution License, allowing readers free access to the works that have been published.

 

Abstract:

 

Organizations working on drug discovery are developing the capacity to measure a number of essential "drug-like" characteristics. The structure-property relationship (SPR) data are an addition to the existing SAR data. With the help of this pharmacological profile technique, research teams can more effectively organise and analyse discovery tests, identify potential "show stoppers," reduce property liabilities, and choose the most deserving applicants for advancement. Teams can use a wealth of information from high throughput property assays for physicochemical properties, such as solubility, permeability, lipophilicity, stability, and pKa, as well as in vitro ADME, which measures metabolism, transporters, protein binding, and CYP inhibition, and in vivo PK/exposure.

 

About this Journal:

Drug Development Research was first published in 1981 and is currently in its fourth decade of existence. The journal's readership includes pharmacologists, pharmacists, toxicologists, medicinal, pharmaceutical, and organic chemists, chemical and molecular biologists, and experts in drug evaluation, approval, and regulation. Its broad scope covers all areas within drug development, from target identification and validation to structure-activity relationship studies, through to post-market clinical reports.

Pharmaceutical Research:

Papers describing cutting-edge research covering the entire spectrum of drug discovery, development, evaluation, and regulatory approval are presented in Pharmaceutical Research, the official journal of the American Association of Pharmaceutical Scientists. Papers published here frequently include small medicinal compounds, genetically modified cells, and biotechnology products like genes, peptides, proteins, and vaccines. Preformulation, drug delivery and targeting, formulation design, engineering, and processing, pharmacokinetics, pharmacodynamics, and pharmacogenomics, molecular biopharmaceutics and drug disposition, and computational biopharmaceutics are some of the areas on which the journal currently places a focus.

Twelve issues of Pharmaceutical Research are released annually.

Pharmaceutical Research: • Covers pharmacodynamics, pharmacogenomics, molecular biopharmaceutics, drug disposition, computational biopharmaceutics, and more. • Presents research across the complete range of drug discovery, development, evaluation, and regulatory approval.

It offers great author service and is an official journal of the American Association of Pharmaceutical Scientists. 97% of authors who responded to a survey said they would certainly or probably publish.

• Post something new in the journal.

Readership:

Experts in the examination, approval, and regulation of drugs, including pharmacologists, pharmacists, toxicologists, medicinal, pharmaceutical, and organic chemists, as well as chemical and molecular biologists.

Aims and scope:

Publishing cutting-edge research that is mechanism-based, hypothesis-driven, and tackles important issues in drug discovery, development, and regulation is a priority for Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists. The following are some current areas of interest: (pre)formulation engineering and processing

• medication delivery and targeting; computational biopharmaceutics;

• Drug disposal and molecular biopharmaceutics (including cellular and molecular pharmacology)

• Pharmacogenetics, pharmacodynamics, and

Nonclinical and clinical studies, as well as in vitro and in vivo methods, may be used in research. It is encouraged to conduct research on small drug molecules, pharmaceutical solid materials (such as biomaterials, polymers, and nanoparticles), biotechnology products (such as genes, peptides, proteins, and vaccines), and genetically modified cells.

Reference and blogs

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https://ucjournals.medium.com/global-research-journal-of-paediatrics-and-child-health-grjpch-9660060ddc27

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[unifiedcitationjournals]

Global Research Journal of Pharmaceutical and Drug Discovery [GRJPDD]

If you are interested in submitting a manuscript to  [GRJPDD] , please visit https://ucjournals.com/journals/  to familiarize yourself with the Journal and the  [GRJPDD] manuscript requirements. When you are ready to submit, please go to https://ucjournals.com/global-research-journal-of-pharmaceutical-and-drug-discovery/

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What is 2-MPPP ?

2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one is a compound structurally derived from 2-Aminopropan-1-one in which the Nitrogen is connected to the Carbon in the 3-position. The physiological and toxicological properties of this compound have not been studied.

2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one may be utilised by researchers who wish to use it as a reference sample for their Gas chromatography/mass spectrometry (GC/MS), Fourier transform infrared spectroscopy(FTIR) or Nuclear magnetic resonance(NMR) analysis catalogues. In stockPriceStock is Available2-MPPP

Laboratory Procedures

For long term storage, we suggest that 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one be stored at -20°C. It should be stable for at least two years.

2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one is supplied as a white crystalline solid. 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one is soluble in organic solvents such as methanol, DMSO, and dichloromethane (DCM), which should be purged with an inert gas. The solubility of 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one in ethanol and DMF is about 22 mg/ml and approximately 15 mg/ml in DMSO.

Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one in PBS, pH 6.4, is approximately 11 mg/ml. We do not recommend storing the aqueous solution for more than one day. References

Indian journal of chemistry, 1981 , vol. 20 B, # 4 p. 303 – 307

Ruddy; Buckley Journal of the American Chemical Society, 1950 , vol. 72, p. 718,719

Kjaer; Petersen Acta Chemica Scandinavica (1947-1973), 1951 , vol. 5, p. 1145,1148

Nasarow; Tscherkasowa Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 122,124, 125 Specifications

SpecificationsSynonyms2-MPPP

IUPAC2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one

PubChemN/A

Cas#N/A

Molecular FormulaC15H21NO

Purity99%

Forumlation / AppearanceWhite Crystal Powder

References Indian journal of chemistry, 1981 ,  vol. 20 B,  # 4  p. 303 – 307 Ruddy; Buckley Journal of the American Chemical Society, 1950 ,  vol. 72, p. 718,719 Kjaer; Petersen Acta Chemica Scandinavica (1947-1973), 1951 ,  vol. 5, p. 1145,1148 Nasarow; Tscherkasowa Zhurnal Obshchei Khimii, 1958 ,  vol. 28, p. 122,124, 125

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