#lymphoblast

[levikra]

I have Acute Lymphoblastic Leukosis aka Blood Cancer

buckle up :D

This post should've been here for sometime now cuz I prefer keeping everyone updated across all the platforms that I use as an artist.

So - Hi! My name is Evein, on 1st of May 2023 I turned 21 and since then, from 5th of May my health decided to pull a quick one on me, propelling the events that currently make me reside at the hospital with an oncology.

It all started with a tonsillitis-like fever, accompanied by furunclosis in three places on my body, a high fever that lasted for 5 days in the first half of May itself and other unpleasant symptoms. It felt weird, I've never had such an intense streak of sicknesses kick my ass like that, but of course - I went to doctors to get checked, the classic blood testings and general examinations and stuff.

That's when on 10th of May my blood test was checked by a dermatologist regarding my furuncle problem and - after some brief moments of her talking with the main doctor at the clinic - I was rushed to the governmential hospital due to the fact that my blood results had... no white blood cells. Literally 1.83 at the accepted range being much higher than that.

Needless to say I was fucking shocked, I've never dealt with the severity of the situation and let alone while being completely on my own as a human person (working, living, providing for myself, you call it).

At the hospital, after several examinations and another blood test came the recommendation paper that doctors signed with urgency, first and foremost I needed to get to an appointment at the hematologist's. That I did on 14th of May and since that point of time, till 19th, I'd been monitored, given antibiotics for my tonsillitis-like symptoms, along with my furunclosis and after 19th we ruled out the condition to be leukosis, became my white blood cells started coming back to normal with the antibiotics aiding my immunity, but despite that - thr condition still seemed as something more reminiscent of mononucleosis (which, however, in another blood test was disproven).

After exactly a week of feeling better, albeit dealing with leftover anemia, I started developing the same symptoms back and even worse, to the point of losing consciousness and thrwoing up in an elevator on 29th of May after going out for the second pack of antibiotics my hematologist had then already approved of to use to help out.

That's when I was rushed to the hospital again and - the next day - my hematologist arranged an appointment at the big clinic that has an oncology ward specifically for my situation. On 1st of June I was officially admitted with Acute Leukosis (the diagnosis doc attached is in Russian).

Since 1st of June the treatment has been ongoing, I've received three rounds of chemo along with supporting hormonal abd antibiotic therapy. Me is balding too, ofc. :D

And thus, this story leads to a logical question - what's now?

It's day 24 of my treatment, out of 4-6 weeks of inital induction period of leukosis' treatment (the overall chemotherapy to destroy tumor cells down to <5% in my bone marrow). After the induction period, if it's proven to lead to remissions - I'm then admitted out to certain periods of time in between infusions + need to take supporting medicine by myself (hence buying it too).

As an independent freelance artist who's existence is tied to being able to do creative work out of, well, any circumstances, I was sadly forced into situation of asking for monetary support, simply because it's stupid to expect to break your own back trying to work harder when you're body is collapsing on itself.

I have a goal on Boosty open for donations and I deeply appreciate ANY and I mean ANY traction of this post. I made a similar thread on Twitter covering the situation and have recieved a lotnof incredible support that has helped me a LOT so far, but my treatment is ongoing, or to be precise - will last in its entirety for 2-3 years. With the momentary help I was able to secure my living situation and get my pet cat to live for the current time period at my friend's, but you understand how that is just a temporary measure and, of course, I don't plan on stall myself - I simply just can't afford that even while hospitalised.

BOOSTY is very sus when it comes to singular donations higher than 120$ but if you happen to donate below that or in several different ones to bypass their antifraud system (only if you wish to) - the link to a goal is here -

[quotesfrommyreading]

Although nowhere near as aggressive as Maria Speyer's leukemia, Carla's illness was astonishing in its own right. Adults, on average, have about five thousand white blood cells circulating per milliliter of blood. Carla's blood contained ninety thousand cells per milliliter – nearly twentyfold the normal level. Ninety-five percent of these cells were blasts – malignant lymphoid cells produced at a frenetic pace but unable to mature into fully developed lymphocytes.  In acute lymphoblastic leukemia, as in some other cancers, the overproduction of cancer cells is combined with a mysterious arrest in the normal maturation of cells. Lymphoid cells are thus produced in vast excess, but, unable to mature, they cannot fulfill their normal function in fighting microbes. Carla had immunological poverty in the face of plenty.

White blood cells are produced in the bone marrow. Carla's bone marrow biopsy, which I saw under the microscope the morning after I first met her, was deeply abnormal. Although superficially amorphous, bone marrow is a highly organized tissue – an organ, in truth – that generates blood in adults. Typically, bone marrow biopsies contain spicules of bone and, within these spicules, islands of growing blood cells – nurseries for the genesis of new blood. In Carla's marrow, this organization had been fully destroyed. Sheet upon sheet of malignant blasts packed the marrow space, obliterating all anatomy and architecture, leaving no space for any production of blood.

Carla was at the edge of a physiological abyss. Her red cell count had dipped so low that her blood was unable to carry its full supply of oxygen (her headaches, in retrospect, were the first sign of oxygen deprivation). Her platelets, the cells responsible for clotting blood, had collapsed to nearly zero, causing her bruises.

Her treatment would require extraordinary finesse. She would need chemotherapy to kill her leukemia, but the chemotherapy would collaterally decimate any remaining blood cells. We would push her deeper into the abyss to try to rescue her. For Carla, the only way out would be the way through.

  —  The Emperor of All Maladies: A Biography of Cancer (Siddhartha Mukherjee)

[thesakurainrain]

Amelia’s Fight Against Leukemia

Hi friends, 

I know it’s been forever since I’ve on here, and I know it’s bold to ask, but this is the one place I’ve not posted this yet. 

This past summer, my baby sister Amelia was diagnosed with Leukemia. I put together a GoFundMe for her. Any little bit helps, and my family and I all really appreciate each donation, share, anything. 

Thank you. I love you all.

https://gofund.me/735ba3e7

[bommagoni]

Acute Lymphoblastic Leukemia Treatment Market Size 2030

[drpawankumarsingh]

Can You Survive Leukemia?

Yes, you can survive leukemia! With the help of Leukemia Specialists, many patients receive effective treatments and live healthy lives. Early detection and advanced treatment play a vital role. Remember, it is important to have a strong support system and follow your treatment plan. With leukemia specialists, there is hope and a path to recovery.

[drpedi07]

Leukemia (Blood Cancer)

ALL is the commonest childhood cancer. The peak age is between 2-6 years. Boys are affected more frequently as compared to girls.

[mitalipingale]

https://sparktv.net/read-blog/17840_t-cell-acute-lymphoblastic-leukemia-market-size-share-and-forecast-2031.html

The T-Cell Acute Lymphoblastic Leukemia Market is projected to expand at a CAGR of 7.7% from 2023-2031.

[cmipooja]

Global Dasatinib Drugs Market Is Estimated To Witness High Growth Owing To Increasing Demand for Targeted Cancer Therapies

The global Dasatinib Drugs Market is estimated to be valued at US$ 4.35 billion in 2023 and is expected to exhibit a CAGR of 6.0% over the forecast period (2023-2030), as highlighted in a new report published by Coherent Market Insights. Market Overview: Dasatinib is an oral medication used for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is classified as a tyrosine kinase inhibitor and works by blocking the action of abnormal proteins that signal the growth of cancer cells. The advantages of dasatinib include its high efficacy in treating CML, ability to target specific cancer cells, and reduced side effects compared to traditional chemotherapy. The increasing incidence of CML and the demand for targeted cancer therapies are driving the growth of the dasatinib drugs market. Market Key Trends: One key trend in the dasatinib drugs market is the growing focus on precision medicine. Precision medicine aims to tailor treatment strategies based on a patient's genetic makeup, lifestyle, and environmental factors. Dasatinib, being a targeted therapy, aligns with the principles of precision medicine by selectively inhibiting specific cancer cells, thereby reducing the likelihood of adverse effects. For example, research studies have identified specific mutations in the BCR-ABL gene, which can affect the response to dasatinib treatment. This trend emphasizes the importance of personalized therapies and molecular testing in optimizing patient outcomes. PEST Analysis: - Political: Government regulations and policies related to drug approvals, intellectual property rights, and reimbursement can significantly impact the availability and affordability of dasatinib drugs. - Economic: The cost-effectiveness of dasatinib drugs compared to other treatment options, as well as healthcare expenditure and insurance coverage, can influence market growth. - Social: The increasing prevalence of cancer, especially CML, and the awareness and acceptance of targeted therapies among patients and healthcare professionals are driving market demand. - Technological: Advances in genetic testing technologies and biomarker identification are enabling the identification of patients who are likely to benefit the most from dasatinib treatment. Key Takeaways: 1: The Global Dasatinib Drugs Market Demand is expected to witness high growth, exhibiting a CAGR of 6.0% over the forecast period, due to increasing demand for targeted cancer therapies. Dasatinib's efficacy in treating CML and its ability to selectively target specific cancer cells position it as a preferred treatment option. 2: In terms of regional analysis, North America is expected to dominate the dasatinib drugs market due to the high prevalence of CML in the region and the well-established healthcare infrastructure. Asia Pacific is projected to be the fastest-growing region, driven by the increasing incidence of CML and the rising adoption of targeted therapies. 3: Key players operating in the global dasatinib drugs market include Bristol-Myers Squibb Company, Novartis International AG, Teva Pharmaceutical Industries Ltd., Sun Pharmaceutical Industries Ltd., Pfizer Inc., Cipla Ltd., Hetero Drugs Limited, Natco Pharma Limited, Dr. Reddy's Laboratories Ltd., and Aurobindo Pharma Ltd. These companies focus on research and development activities to develop innovative therapies and expand their product portfolios.

[ultradannyboyblog]

Why This Fundraiser Is Very Important

I sometimes get choked up because of something that breaks my heart – and this picture of Chona’s grandnephew is worth a thousand words. His name is Jayce Lore Astley, and Chona is one of my gal pals from the Vancouver Venturers Walking Club. Jayce is just four years old and was diagnosed with All-Acute Lymphoblastic Leukemia. Chona said they have a GoFundMe page that her niece’s friend has…

[bellarogness]

Lol I had a melt down and then I was ok but I made this bc I was just like >:( having leukemia and a judgemental family is hard. I'm struggling to keep up with the pace of life. Sucks to suck I guess lmao. If you're wondering what the fuck is going on w her hands, she's picking them. I pick my hands when I'm anxious. Self inserts are gay but so am I

[ijcimr]

An ‘Uncommon early lineage switch’ in an MLL rearranged adult B-lineage Acute Lymphoblastic Leukemia to Mixed-phenotypic acute leukemia (B/Myeloid) by  Narendra Agrawal in International Journal of Clinical Images and Medical Reviews 

Case Report

Lineage switch is an infrequent phenomenon with an incidence of ~ 0.6% of all de novo leukemias and seen in almost 6% of relapsed cases. This phenomenon is observed following therapy or at the time of relapse. Switch in lineage tends to occur in younger patients and is associated with particularly poor outcomes.[1]

https://ijcimr.org/wp-content/uploads/2022/01/Fig-1__1_.jpg

Discussion

Our clinical report illustrates an adult refractory B -ALL with t (4;11) (q21;23), AF4:MLL fusion who transformed to Mixed-phenotypic acute leukemia;KMT2A-rearranged during his second month of therapy. Lineage switch in MLL rearranged paediatric ALL is common, but in adults it is not well reported. During the literature review, we found 2 cases of adult ALL harbouring t (4;11) transformed to AML [1,4]. First case illustrated chemotherapy responsive MLL rearranged B-ALL who underwent allogeneic stem cell transplantation (Allo SCT) in remission after induction therapy, who transformed to AML post 100 days of Allo SCT[4]. Second case illustrated refractory MLL rearranged B-ALL adult that rapidly transformed to AML following initiation of blinatumomab therapy [1].  However there was no case found to have switched from B acute lymphoblastic leukemia to Mixed-phenotypic acute leukemia;KMT2A-rearranged .Mechanism for lineage switch in MLL rearranged acute leukemia is not clear yet. Reports showing a strong trend of lineage switch involving B and myeloid lineages suggest that B myeloid progenitor might be involved in the mechanism of lineage switch. Studies reporting lineage switch post anti CD19 therapy; blinatumomab and CD19 chimeric antigen receptor (CAR-T), further advocates this theory [3].In our case it is not possible to state that transformation occurred post Venetoclax therapy, as flow cytometric evaluation was not done prior to start of venetoclax therapy. Development of secondary AML as a result of therapy related process can be ruled out in view of early lineage switch (< 6 months of therapy) and consistent finding of the t (4;11) (q21;23) at diagnosis of B-ALL and transformation. The (4;11) rearrangement detected at diagnosis, and phenotypic switch suggests that the original clone harboured a bi-lineage potential. If further genetic studies including NGS or gene expression studies done at baseline could have predicted the bi lineage potential is also unclear as the case reported by Haddox C et al did not show any change in the baseline NGS and the NGS performed during relapse.In conclusion, haematologists should be cognizant while treating MLL rearranged B -ALL adults for a lineage switch. It also underlies the importance of repeat evaluation of the disease if there is no response to standard therapy.

Declarations

Funding Funding information is not applicable to this study.Conflict of Interest All authors declare no conflict of interest to declare.Compliance with Ethical Standards Ethical Approval Statement: All authors stated that the study has been approved by the appropriate institutional review board and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.Acknowledgement We are thankful to our RGCI & RC staff of department of Hematology for their constant supportFor more details: https://ijcimr.org/editorial-board/

[drpawankumarsingh]

Can Bone Marrow Transplant Cure Leukemia?

Yes, a bone marrow transplant can potentially cure leukemia by replacing damaged or diseased bone marrow with healthy cells. If you need expert advice, consult with a Bone Marrow Specialist in Gurugram. Dr. Pawan Kumar Singh offers the Best Online BMT Consultation, providing advanced treatments and personalized care. Trust Dr. Singh for comprehensive and compassionate care in managing and treating leukemia. Schedule your consultation today for the best support.

[drpedi07]

Toronto Childhood Cancer Staging criteria for Acute lymphoblastic leukaemia Calculator

These results provide the first population-wide picture of the distribution and outcomes for childhood blood cancers by extent of disease at diagnosis and provide a baseline for future comparisons.