#maraia

[hopefulngold]

lovers

[impmakesart]

Finally, a picture of Jere and Maraia, together. Trans solidarity.

[maraiabex]

*ੈ✩‧₊˚sc: mya.miller123 *ੈ✩‧₊˚

[themissingteasp69n]

[chromatoiromaraia]

Maraia, Little sister

[pharmacologyassist]

The PARP1-Siah1 Axis Controls HIV-1 Transcription and Expression of Siah1 Substrates

Graphical Abstract

Highlights

•PARP1 activity is required for optimal Tat activation of HIV-1 transcription

•PARP1 increases levels of ELL2 protein and ELL2-SEC, key for Tat-transactivation

•PARP1 and NCoR inhibit transcription of Siah1, an E3 ubiquitin ligase for ELL2

•PARP1 induces proteosomal degradation of Siah1 likely through a PARdU mechanism

Summary

Recent studies have revealed a key role of PARP1 that catalyzes the poly-ADP-ribosylation (PARylation) of substrates in regulating gene transcription. We show here that HIV-1 transcriptional activation also requires PARP1 activity. Because efficient HIV-1 transactivation is known to depend on the ELL2-containing super elongation complex (SEC), we investigated the functional relationship between PARP1 and ELL2-SEC in HIV-1 transcriptional control. We show that PARP1 elevates ELL2 protein levels to form more ELL2-SEC in cells. This effect is caused by PARP1’s suppression of expression of Siah1, an E3 ubiquitin ligasefor ELL2, at both mRNA and protein levels. At the mRNA level, PARP1 coordinates with the co-repressor NCoR to suppress Siah1 transcription. At the protein level, PARP1 promotes Siah1 proteolysis, likely through inducing PARylation-dependent ubiquitination (PARdU) of Siah1. Thus, a PARP1-Siah1 axis activates HIV-1 transcription and controls the expression of ELL2 and other Siah1 substrates.

[dridersgeorg]

Dear Maraias Mask: I am in Hell

[storiesofoldgreeceandrome]

Homer: The Odyssey 彡 FULL NOTES ︶꒦꒷♡꒷꒦︶ [x]

[somewhereontheeastsideofsorrow]

who lives with who - WABBBAD

The Lupin-Blacks

Sirius Lupin-Black

Remus Lupin-Black

*Isaiah Lupin Black - gryffindor

*Max Lupin-Black - slytherin

Teddy Lupin-Black - slytherin

- All the kids are adopted (obviously)

The Mckinnon and Meadows

Marlene Mckinnon

Dorcas Meadows

The Potters

Lily Potter

James Potter

Harry Potter -gryffindor

The Riddles/Notts

*Maraia Riddle

*Tiberius Nott

Tom Riddle - slytherin

Mattheo Riddle - slytherin

Theodore Nott - slytherin

Rue Nott - Maraia and Tiberius's daughter

- Tiberius's wife, Theodore's Mum, *Amory, died when Theo was born, due to birth complications (won't go into full detail in story, maybe only one or two mentions but read the warning at each chapter). Tom and Mattheo's Dad died when Mattheo was 2, Tom was 3, as he was killed by deatheaters. So when Theo and Mattheo were 13 and Tom 14, Tiberius and Maraia got together then 3 years later Rue was born.

The Black/Malfoy

Narcissa Black

Draco Malfoy - slytherin

- Narcissa kicked Lucius out years ago because he is a deatheater and she didn't want her child to grow up like she did.

The Berkshires and Zabini

*Claire Berkshire

*Charles Berkshire

Lorenzo Berkshire - slytherin

Juniper Berkshire - Ravenclaw

Blaise Zabini - slytherin

Blaise lives with the Berkshires because his Mum is rarely there and only shows up every few months and he doesn't know who his Dad is.

The Primswoods

*Martha Primswood

*Lionel Primswood

*Dylan Primswood - slytherin

*Xander Primswood - hufflepuff

OTHER CHARACTERS all the Weasleys, Hermione etc. other OC's

*means O.C

[vhopezine]

Brand New Day: A Vhope Zine Introducing The Team

We're so happy to introduce our bright and beautiful team of artists, writers and mods!

Together, we're hoping to create a zine dedicated to the relationship between Jung Hoseok and Kim Taehyung of BTS. The zine will be available physcially and digitally, with the hope that we can raise money for a nominated charity.

Follow us on twitter | instagram | caard

Where you can find our contributors and mods

Mod Team: Ashhie: twitter: AiSeeHope | tumblr: @aiseehope Allié: twitter: onlypreciouslov Lo: twitter: junghomobi | tumblr: @junghomobii Vhesio: twitter: vhesiho | tumblr: @vhesio

Artists: Ada: twitter: greenmoonie | tumblr: @greenmoonies Aki: twitter: amaiaaki Altie: twitter: AltieDraws Ama: twitter: inflickers Ann: twitter: ayilings Arisu: twitter: Aris_art_hell Bebe: twitter: bebe_sope Bee: twitter: _bluebees Blu: twitter: blusseok Circa: twitter: circadraws Conneeh: twitter: conne_eh Daisy: twitter: glassrtz | tumblr: @glassrtz Diya: twitter: mintminnim Ejiko: twitter: dopeshow401 Fanny: twitter: pan_ninie Hanpa: twitter: 0n1yh0pewe11 LynaH: twitter: lynahcz Maraia: twitter: hopefulngold | tumblr: @hopefulngold Nyom: twitter: nyom_side Plume: twitter: plumadot Rei: twitter: Gresiteisland Ruthie: twitter: sopedoods Si: twitter: si_sss_ Strawberry Flamingo: twitter: strawberryflam | insta: strawberryflamingoh Toya: twitter: toya12_kp Ty: twitter: iwannaeatpasta Vhesio: twitter: vhesiho | tumblr: @vhesio Zam: twitter: zam_chala

Writers: Alex: twitter: murderoustannie Ashhie: twitter: AiSeeHope | tumblr: @aiseehope Kate: twitter: distantbluesky | tumblr: @distantbluesky Lauren: twitter: ladyhobi Lo: twitter: junghomobi | tumblr: @junghomobi

[spacepigfanclub]

Remaking my OC ref sheet be like

I also wanna make a version with Maraia wearing armor with the sigil of Caed Nua

I'm also making Cosmo the carrier of Mara's stuff

A good boy, a very very good boye that is employed and doing his share of work, Torchlight style

...Cosmo is lazy af, and yet even he works harder than Lord Gathbin >:3c

[hopefulngold]

i dreamt of you

[ninaemsaopaulo]

"Tina Turner faleceu", noticiei, achando que já estivesse fora desse plano há algum tempo. A gerente, 50 anos:

- Mentira!

A vendedora, 22 anos:

- Quem é?

Eu, explicando:

- Tina Turner foi a Beyoncé da época da gerente. Assim como Whitney Houston foi a Mariah Carey dela.

A novinha:

- Maraia quem?

E Maraísa.

[themissingteasp69n]

paris_remix.mov

[chromatoiromaraia]

Maraia, Prophecy

[elrodolforodrigues]

✨ sodades migles 🎅 feliz natalz ✨ 🎶 any 🎵 maraia query 🎶 . . . . . . . . . . . . . . . . . . . . . . #Gay #gayboy #gayhotties #gayman #lisboa #lisbon #hotguys #gaymen #hotguysportugal #gays #sexydudes #gayhot #gayteen #telavivgay #gayrj #gaybr #gayriodejaneiro #gaydude #lisbonne #iamhoscos #favoboys #gayboys #gayberlin #gayguys #gaysp #gayhunk #gaytwink #lisbonlovers #gaytelaviv . . . (em CONSTRUCTION Lisbon Club) https://www.instagram.com/p/CmWYovpNZd7/?igshid=NGJjMDIxMWI=