#omicron virus

[rightnewshindi]

कोरोना वायरस JN.1: भारत और विश्व में 2025 में फिर बढ़े मामले, जानें इस वैरिएंट के बारे पूरी डिटेल #News #RightNews #HindiNews

[lenterablog]

Evolusi dan Dampak Varian Baru COVID-19 Terkini

COVID-19 terus menjadi ancaman global, meskipun vaksinasi dan pengobatan telah berkembang pesat. Salah satu tantangan terbesar yang dihadapi oleh dunia adalah munculnya varian-varian baru dari virus ini. Menurut www.igcp585.org, varian Omicron dan subvarian XBB, misalnya, telah menjadi sorotan utama karena sifat mutasinya yang cepat dan dampaknya terhadap tingkat infeksi, keparahan penyakit,…

[wahyugunawanpbb]

Jasa Disinfektan Rumah di Tangerang Selatan | 0813-8299-9966 | Garda Pest

Memerlukan Info Untuk Jasa Disinfektan Rumah di Tangerang Selatan ? Segera Hubungi Customer Service Garda Pest Control di 0813-1344-4221 Layanan 24 Jam – Harga Terjangkau – Teknisi Profesional dan Tersertifikasi Assphami, Dapatkan Promo Diskon 10% atau Free Disinfektan Virus 1 Unit Mobil Untuk Pemesanan Via Aplikasi. Jasa Disinfektan Rumah di Tangerang Selatan Pada tahun 2023, dunia terus…

[priangancom]

Peringatan Terkini: Lonjakan Kasus COVID-19 di Indonesia, Protokol Kesehatan Harus Diperketat

Jakarta, 6 Desember 2023 – Direktur Jenderal Pencegahan dan Pengendalian Penyakit, Maxi Rein Rondonuwu, kembali memberikan peringatan kepada masyarakat Indonesia untuk meningkatkan kewaspadaan dan disiplin dalam menerapkan protokol kesehatan (prokes) mengingat adanya peningkatan kasus COVID-19 dalam beberapa pekan terakhir.   Berdasarkan data terbaru Kementerian Kesehatan per 6 Desember 2023,…

[situationlately]

[x]

[natugardener]

The global death rate did decline dramatically after Omicron.

[covid-safer-hotties]

Also preserved on our archive

By Anthony Robledo

The side effects of newly discovered COVID-19 strain XEC might not be as severe, but is part of the more contagious variant class, experts say.

The Centers for Disease Control and Prevention (CDC) defines XEC as recombinant or hybrid of the strains KS.1.1 and KP.3.3., both from the Omicron family that became the predominant strain in the U.S. late December 2022.

The variant, which first appeared in Berlin in late June, has increasingly seen hundreds of cases in Germany, France, Denmark and Netherlands, according to a report by Australia-based data integration specialist Mike Honey.

XEC has also been reported in at least 25 U.S. states though there could be more as genetic testing is not done on every positive test, RTI International epidemiologist Joëlla W. Adams said.

"We often use what happens in Europe as a good indication of what might happen here," Adams told USA TODAY Friday. "Whenever we're entering into a season where we have multiple viruses occurring at the same time, like we're entering into flu season, that obviously complicates things."

What is the XEC variant? New COVID strain XEC is a recombinant strain of two variants in the Omicron family: KS.1.1 and KP.3.3.

The hybrid strain was first reported in Berlin late June but has spread across Europe, North America and Asia with the countries Germany, France, the Netherlands and Denmark leading cases.

Is the XEC variant more contagious? While there's no indication the XEC strain will increase the severity of virus, it could potentially become a dominant strain as Omicron variants are more contagious. However, current available COVID-19 vaccines and booster shots are particularly protective against XEC as it is a hybrid of two Omicron strains.

"These strains do have the advantage in the fact that they are more transmissible compared to other families, and so the vaccines that are currently being offered were not based off of the XEC variant, but they are related," Adams said.

Like other respiratory infections, COVID-19 and its recent Omicron variants will increasingly spread during the fall and winter seasons as students return to classes, kids spend more time inside and people visit family for the holidays, according to Adams.

How can we protect ourselves from XEC and other variants? The CDC continues to monitor the emergence of variants in the population, according to spokesperson Rosa Norman.

"At this time, we anticipate that COVID-19 treatments and vaccines will continue to work against all circulating variants," Norman said in a statement to USA TODAY. "CDC will continue to monitor the effectiveness of treatment and vaccines against circulating variants."

The CDC recommends that everyone ages 6 months and older, with some exceptions, receive an updated 2024-2025 COVID-19 vaccine to protect against the virus, regardless whether or not you have previously been vaccinated or infected.

Norman urged Americans to monitor the agency's COVID Data Tracker for updates to new variants.

KP.3.1.1:This dominant COVID-19 variant accounts for over 50% of cases, new CDC data shows

What is the dominant strain of COVID in the US? COVID-19 variant KP.3.1.1 is currently the dominant strain accounting for more than half of positive infections in the U.S. according to recent CDC projections.

Between Sept. 1 and Sept. 14, 52.7% of positive infections were of the KP.3.1.1 strain, followed by KP.2.3 at 12.2%, according to the agency's Nowcast data tracker, which displays COVID-19 estimates and projections for two-week periods.

KP.3.1.1 first became the dominant strain in the two-week period, starting on July 21st and ending on August 3rd.

"The KP.3.1.1 variant is very similar to other circulating variants in the United States. All current lineages are descendants of JN.1, which emerged in late 2023," Norman previously told USA TODAY.

COVID XEC symptoms There is no indication that the XEC variant comes with its own unique symptoms.

The CDC continues to outline the basic COVID-19 symptoms, which can appear between two to 14 days after exposure to the virus and can range from mild to severe.

These are some of the symptoms of COVID-19:

Fever or chills Cough Shortness of breath or difficulty breathing Fatigue Muscle or body aches Headache Loss of taste or smell Sore throat Congestion or runny nose Nausea or vomiting Diarrhea

The CDC said you should seek medical attention if you have the following symptoms:

Trouble breathing Persistent pain or pressure in the chest New confusion Inability to wake or stay awake Pale, gray or blue-colored skin, lips, or nail beds

[genderqueerdykes]

the COVID 2024-2025 vaccine is now available in some areas, please look into getting yours ASAP

i am a COVID survivor who is dealing with long COVID and permanent lung damage due to having caught the virus in October of 2023. this isn't a flu or a cold. this disease causes serious, permanent long term damage. i'm still struggling with even worse brain fog than i already had previously and sometimes it becomes extremely hard for me to breathe, even in good conditions.

COVID has been surging like crazy in the US this summer due to folks socializing more closely and masking no longer being required in most places. social distancing does not happen here anymore. we need to protect ourselves even while there are not mandates and rules in place stating that you MUST be masked (you still should be masking).

the CDC is stating that everyone ages 6 months and older should get the 2024–2025 COVID-19 vaccine:

even if you have been vaccinated in the past you still need to keep up with current vaccines as their protection decreases over time, and COVID continues to mutate and become different strains that are resistant to previous vaccines. staying up to date and masking are the only ways to stay safe. viruses mutate to adapt to their hosts, and COVID is no different.

there are currently 5 variants of the Omicron strain of COVID that are responsible for the uptick in recent cases:

from a COVID survivor who doesn't want to go through this shit a second time: vaccinate. wear your masks. wash your hands. social distance. quarantine when sick. take this seriously. it's been 4 years and COVID has done nothing but prove it is here to stay unless we make a huge change in our society.

[scatter-snz]

Best Laid Plans - Part 1

Details: 9k, Male sneezes, no pairing (yet..)

Summary: A secret agent is going undercover for a few days, and his target has a sneeze fetish. The agency’s best engineer has constructed something to give him an edge.

PART 1 - PART 2

My first original piece I've posted here!

This is VERY self-indulgent so you’ll have to excuse me lol. It’s like.. lizard brain horny. Seriously lol. Slapping NSFW on here for good measure. It’s rare I get embarrassed about my kink nowadays but I feel a little embarrassed about this one. Still, I had fun writing it! I hope someone else can enjoy it too! 

These are original characters, all in their mid twenties to early thirties! This story was inspired by @testingtwns writing. She has such captivating descriptions, spectacular characterizations, and fascinating world lore. (If you would prefer I remove this shoutout, Red, please let me know! Your stuff is just so great!)

(Warnings: Unrealistic science, my cringe attempt at sneeze characterization, Mess Lite™, questionable workplace dynamics, general horny undertones and overtones, accidental boners and feeling pleasure from sneezing).

THIS STORY IS NSFW!

-

It was never a great morning when Agent Omicron found himself in Dr. Anita Voster’s lab. She was a little eccentric, he thought, and liked to make mischief. Not a good combination for a scientist. Still, she was the best in the force and the one assigned to his case by the powers that be. He knew why he was reporting to Dr. Voster’s lab and he knew what his bosses would say - The sooner you report to Dr. Voster, the sooner you can begin your work.

Omicron reported to her lab sharply at 0800, shrugged off his suit jacket at her behest, and sat himself down in her vaguely threatening patient chair for the administration of her invention. Dr. Voster was far too giddy in handing over a small container of nasal spray. It looked harmless, but Omicron knew better.

“This,” he said, inspecting the bottle, “will make me sick?”

“Something like that,” Dr. Voster replied. She fetched the bottle from his hand as she spoke, and rolled a plush stool over to sit as they talked. “This virus was engineered specifically to make you sneeze, so think of it like a cold in your nose.”

“Similar to allergies?”

“Yes, if you were allergic to air.”

Omicron sighed. He wasn’t in the business of complaining, but this was going to be challenging. He crossed his arms, trying not to fidget. “How long does it last?”

“Just long enough to see you through the mission. Your symptoms should abate by Thursday.”

So he’d be sick the entire time, essentially. Great. His leg started to bounce.

“Will this slow me down?” he asked. Dr. Voster arched a look over her safety glasses. He clarified himself. “Am I going to feel like shit?”

She smirked at him. “Are you one of those man-cold types?”

Heat swept over his ears and burned the back of his neck, and her smile only widened. He crunched his brows with a glare. “No, I’m just being thorough. If this will compromise my performance in any way, I want to know about it.”

“It won’t,” she chuckled, and he tried not to get defensive at the amusement in her voice. “Like I said, the primary function of this virus is to make you sneeze. You’ll be contending with some nasal congestion, but aside from that you’ll be fine.”

That was easy for her to say. She wasn’t going undercover into enemy territory. He tensed as she snapped on a pair of gloves and looped on a face mask. When she uncapped the bottle, he cleared his throat. “The paperwork said something about me being more ‘suggestible?’ What does that mean?”

She huffed at his air quotes and yanked down her mask. “It means you’ll be vulnerable to psychosomatic triggers. In other words, if you think hard enough about sneezing, you’ll prompt one.”

“That sounds unlikely.”

“We have testing data to support it,” she chastised, and yanked her mask back up. “It was a goal for the formula. We thought you might find it handy to take matters into your own hands if a sneeze wasn’t forthcoming.”

“For.. what? Tactical measures?”

“Yes, strategic options. Now, tilt your head and relax.”

He reluctantly settled back into the cushioned chair, sniffing in preparation. One of her latex hands moved to cradle his jaw and keep him still as she nudged the applicator up the right side. It was wide enough to graze the sides of his nostrils, and he felt them flare in response.

“Okay, deep breath..”

Swallowing, he breathed slowly, deeply through his nose. A fffssh from the bottle yielded a mist of curiously warm aerosol that instantly coated the skin. He flinched a wrist up to his mouth to cough in response. It felt suddenly like his nose was running, so he sniffed, sniffed, and sniffed again. A strong flavor coated the back of his throat.

“Why is it salty?”

“Well, we didn’t intentionally flavor it,” she said, already moving to his left nostril. “Probably the saline. We used it as a base. Now, give me another big breath.”

He did as he was told, and again a warm puff of wetness invaded his nose. And another. And another. They performed this three times for each nostril, alternating sides, and the last one rubbed him wrong. A tiny tickle ignited. Omicron warded Dr. Voster back with one cautious hand as the other routed to his nose. He anchored his forefinger beneath his nostrils, pressing deliberately against his septum as he parted his lips to breathe. Voster snorted at him as she set the bottle aside.

“I thought that only worked in cartoons.”

“And on me,” he mumbled in a heady voice. 

It took a moment of concentrated effort, but the urge passed. He sniffed, a little wetter this time as he blinked away tears. Agent Omicron was an old hand at holding back sneezes. Sudden, uncontrolled outbursts weren’t great for business when he was out in the field. That, and he generally didn’t like to draw attention to himself even in civilian life. He caught Dr. Voster smiling at him and his brows trenched.

“What now?”

“I’m not into sneezing,” she told him as she capped the bottle, “but that was pretty cute. Your target won’t stand a chance, Mr. Honey Pot.”

He replied with a scowl and one more see-sawing rub beneath his nose. “When does this kick in?”

“Give it twenty-four hours,” she said, and snapped off her gloves. “I’ll check on you then to make sure it took.”

He stood and slipped back into his jacket, straightened his tie. “Isn’t this cutting it a little close? I’m flying out tomorrow.”

“Maybe, but we didn’t want your poor nose suffering anymore than it has to,” she cooed, and punctuated this with a little tap of her knuckle to his septum. He swatted her away.

“Stop.”

“Oohhh,” she pouted, leaning a hip against her workstation. “Always so serious, Agent O.”

Omicron lurked a warning glare her way as he adjusted his sleeve cuffs and shirt collar. “I’ll be back in 2400.”

---

And he was, though he dragged his feet most of the way.

Omicron believed Dr. Voster when she said this nasal spray contained a virus that would cause his nose some hell, but he didn’t quite understand just how.. intense the experience would be. 

He sniffled, a necessary indignity since he woke up this morning, and the slow, deliberate flare of that ever-present irritation beckoned him toward an unavoidable conclusion. Still, Omicron shoved the hard edge of his finger beneath his nose and tilted his head back for another whip-crack sniff. It flared the tickle dangerously, but the steady breakwater against his septum kept him in the clear. His nostrils twitched and he pinched them, rubbing rubbing rubbing until he heard the embarrassing squelch of something wet in his nose.

Another strong sniff, and a weak huhh on his exhale. Shit. He wiped his hand on the side of his pants with a grimace. He’d have to start carrying tissues.

“There he is!” Dr. Voster greeted him with a disarming smile, but he could see the hawklike way she zeroed in on his nose. He tried not to sniffle. “How’s my magnum opus treating you?”

It’s bullying me, Omicron thought, but as he laced his hands properly behind his back, what he said instead was, “It’s working.”

“Oh, is it?” she said. She wasn’t even trying to mask the delight in her voice now as she crowded him back into her exam chair. “Let me take a look.”

He stared hard at the ceiling as she slipped on gloves and wheeled forward on her stool, leaning over him like a dentist. He hated the dentist. A warm trickle of wetness prompted an automatic sniff, and a huffing exhale when that far-back tickle teased him.

“Runny nose?” she chirped, using her thumb to gently coax his nostril open. She held an otoscope with her other hand, using the little light to peer up his nose. Omicron tried not to shrivel in embarrassment as she crooned with sympathy. “Oooh, poor thing. You’re so inflamed..”

“Wasn’t that the idea?” he sighed, and sniffled again. A spark somewhere in his sinuses caused him a hard blink.

“Yes, but it must tickle so much..”

In response to her words, another spark snapped inside him. Like striking flint to burn kindling. Another reflexive sniffle. His eyes began to water. 

“It must feel like something fuzzy is stuck up there,” she was saying, rubbing her thumb softly against the quivering edge of his nostril. “Every time you breathe, this fluffy thing, lodged in place and too far for you to reach..”

The frantic efforts of the virus continued, tenacious now in its purpose. The fuse caught, as did Omicron’s next inhale. His chest hitched with a stutter. He tried to reach up, finger extended and ready, but Voster caught his wrist and pinned it back down to the chair arm.

“It must be new for you, to be so out of control. This thing inside you, tickling so sweetly, growing unbearable, and there’s nothing you can do but submit.”

That tantalizing feeling got worse. The line of gunpowder trailing through his pulsing nostrils lit up with an unstoppable blaze. It raced through him, and Omicron couldn’t do anything but give it fuel. He gasped hugely, his chest straining against the buttons of his shirt. The exhale crashed out of him clumsily, unrelieved.

“H-HUHhh..”

Dr. Voster leaned away, but set her otoscope aside to pin his other wrist when he reflexively raised it to ward off what was coming. “Don’t fight it, Omicron. That tickle nestled in your nose was built for this. Listen to it. You two are a team, remember?”

Omicron couldn’t even open his eyes, the sensation held him so powerfully. It felt alive, calculated, somehow vying for control. He snatched in another soft breath, breathed it out on a moan, and then gasped again. His lungs strained to accommodate as that demanding tickle wanted more.. more..

He huffed out another helpless groan. “HHUHhhh..”

His hands flinched toward his face, but met resistance. A tear surfed down his cheek and dripped off his chin. He gasped- gasped-! “.. hH-hiIHH-!”

The sensation crested, and finally, overcame him.

“HHZZZSSSCHOOO!!”

The force of it threw him forward. It was the loudest, strongest sneeze he’d ever sneezed, but somehow it didn’t feel big enough. Cool, tingling aftermath quickly gathered a second storm. This time, Omicron didn’t do anything but breathe into it.

“..hhHI’JJIZZSHHUE!”

Another uncharacteristically enormous sneeze. His wrists were free, but he didn’t even bother to cover his mouth or muffle into his elbow. Usually he’d rather disintegrate than sneeze freely even in his own home, but.. this tickle.. he just wanted to let it.. let it do.. 

“HEH’CHIZSHOoo!”

.. do whatever it wanted. And what it wanted was complete and utter domination. Omicron sniffled helplessly, half-aware he was leaking out of more than one orifice but too punch-drunk to do much about it. His breath caught fitfully in his throat and he-.. 

“-idzhih.. HID’ISSsshoo!.. huhh..”

Omicron leaned over to press hands over his eyes, his palms coming away wet. He was normally a one-and-done guy, with fairly normal-sized sneezes; this many at this size had him light-headed. His breath hitched again, quick like the strike of a viper, before he let it go on a sigh. And another, just the same. It felt like hiccups. He didn’t dare touch his nose, too wary of setting off the wrath of this thing deep inside him. Instead he just sniffled pitifully, catching his breath.

There was a tap on his shoulder. He glanced askance to a sheepish looking Dr. Voster who was offering a box of tissues. He snatched several, still too dazed to be properly embarrassed as he blew a wet, crackling sound into the wad of them. It took a few rounds, but when he finished he cleared his throat and blinked at her with teary eyes.

“What the fuck, Anita.”

“Sorry,” she winced, and she actually did seem sorry. “I wanted to test the ‘suggestible’ variable and you reacted more strongly than I anticipated. Also, um.. bless you, by the way.”

He sat back against the seat with a stuffy sniffle, arms crossed, and now that he was more aware of himself, valiantly fighting down the urge to blush. “Yes, well. You were just doing your job, so I can’t be mad.”

She hedged a nervous smile. “Can’t be, or shouldn’t be?”

He gusted a long sigh, reaching up to rub the bridge of his nose when somehow even the rumble of his own voice stirred the residual dust of another sinus-deep tickle. “Do you need to test anything else, or can I go?”

His voice had lost most of its resonance from the sneeze attack as the congestion set in -- not yet enough to blunt his consonants but enough to dull the overall sound. Moisture skated down the side of his nose and Omicron wrinkled it with another snuffle that moved nothing at all. How could his nose be both dripping and completely blocked? He indulged a rub this time, soothing his nostrils to stillness with the tempering back-and-forth of his index finger.

The doctor’s voice broke the quiet. “How does it feel?”

Omicron peered up at her, finger still held to his upper lip. “Pardon?”

“Your nose,” she clarified, but not by much. “How does it feel?” He scoffed and stood to leave. She stood to stop him, holding both hands out as if to placate him. “I’m not teasing you. I really do need to know. Are you in pain?”

“No,” he said, chest lifting with another short sniff. He pressed harder against his septum, rubbing in earnest now as the tickle began gathering momentum. It stalled against the wrangling touch, but didn’t back down. “No pain.”

“But it does tickle?”

“I believe we’ve estahh..hkrrrm!” He cleared his throat to steady his voice. “.. established that, yes.”

She eyed him, her gaze trailing down to the finger glued beneath his nose. “You shouldn’t try to hold them off, Omicron. It might be why your sneezing earlier was so extreme.”

All this talk of sneezing was just emboldening the tickle. It’s like the sensation was surging forward, eager to answer to the call of its name. His eyes fluttered closed and he pressed his tongue to the roof of his mouth to try and waylay another gasping breath. His nostrils pulsed against his finger, prompting him to pinch them instead, but still they tried to flare against his grip. He heard Dr. Voster sigh.

“I don’t know why they picked you for this mission,” she muttered, just loud enough to be heard. “If you’re too shy to sneeze, you’re going to lose your target pretty much instantly.”

His eyes sliced open, as defiant as his nose still squirming between his fingers. His voice was bottled back in his throat completely. “I’b dnot shy, I’b.. I’b jhhss.. hooh..”

The tickle hijacked his voice, tremoring it on a snatchy inhale. It prickled ominously behind his eyes, insistent, and Omicron stayed perfectly still in an effort to tame it. Even with his nose plugged and his fervent attempts to rub the sensation away, the tickle persisted. It dragged another breath in on a soft gasp, out on another dreading utterance.

“.. H-Ihih!.. ohh..”

“You’re so stubborn,” said Dr. Voster, and he could hear her rolling her eyes. He’d known her for years, and while he tried to rise above her goading taunts, there always came a point when she got to him.

Omicron let go of his nose and took as long and deep of a breath as he could through his trembling nostrils. The tickle welcomed it, greedily advancing, and rather than prolong the fight Omicron simply braced his hands on his knees to keep his balance as the sensation built inside him. As Dr. Voster so strangely asserted during his last volley, he and this virus were a team. He wouldn’t see the success of this mission without it.

It was this thought that compelled him to breathe again, a sniff that coasted directly into a gasp. He waited, hovering on the edge of it, but the sneeze backed away just before he could snatch it. Omicron squinted up at Dr. Voster, who was watching him with bald interest.

“Iihhff… hoo..” He sniffled, abandoning all dignity as he snubbed the wet edges of his nostrils against the sleeve of his suit. “If I let this tiH.. tiihckle ha..uuHUhh.. have its way ev..” 

His eyes fluttered closed, and he snatched in a series of chuffing breaths. Each was a shrill gasp followed by a bleating exhale, utterly beyond his power to stop. The crescendo carried him into increasingly higher and faster octaves, before the sneeze ripped out of him with gusto.

“HAH’CHIZSHOO!-ohhhh..” He swayed on his feet, panting at the ground, and was shocked to find in the tingling aftermath how good that felt. It made it easier to let the next one swell and crash out of him. “..HIH’SSschoo!- fuck mbe..”

Omicron rarely swore aloud, but the power and sheer abandon of these sneezes were so unlike his usual that he couldn’t help it. Through the haze of another rising tickle, he tried to hurry through the rest of his thoughts before he completely forgot what he was saying.

“If I let it have.. hahve it’s wayiiiiee..ig’GIZZSCHue!!-hah... I’ll be sdnee.. sdiizz.. HIZZSSSHOO!!..ughh, sdeezig for..fuh! UH!hhh.. for days.” He finished on a sigh, unrelieved, one hand now holding desperately onto the chair so he didn’t end up on his knees.

Dr. Voster didn’t immediately speak and when he finally blinked away blurry tears, he found her biting her lip with a worried crease between her eyes. “.. Do you always sneeze like this when you catch a cold?”

Even the very word caused his nose to buzz. His willpower was all but shredded, so he clamped onto the chair with his other hand and threw his head down with a body-shaking, “IID’DZZSSSSSTTH!!”

It was an unfortunate sneeze, one that painted his tie and the seat of the chair with its aftermath. Omicron didn’t have the energy to blush about it; honestly, this was all Anita’s fault so if he happened to catch her furniture in the crossfire of his helpless sneezing fit he.. heeeeeeee-

“HEEZZZSHOOO!!” He stumbled forward into a suspended tray of implements that crashed to the ground in a tremendous clatter. Omicron paid it no mind, tilting his head back to the fluorescent lights in an effort to keep his running nose at bay. “Ugh, won’t it st.. uh.. ohh.. hH!”

A bridge of pressure appeared beneath his septum, pressing firmly against it. He cracked his eyes open to find Dr. Voster beside him, her finger fearlessly anchored beneath his flaring nostrils. They threatened another revolt, under the tickle’s full command. That enduring, swelling force inside Omicron begged again for release and he gasped loudly against Dr. Voster.

“..hihHIT-!”

“Nope, nope, nope,” she muttered, pressing even harder against his nose. “Work with me here..”

Omicron had no idea if she was talking to him, or the virus, but both struggled to comply. The maddening prickle became tortuous. His nose cried out for relief, as the tickle played his sinuses like a fine instrument. Holding it back now seemed impossible. And to be frank, he was still a bit irked with Anita. He flicked his gaze up to the lights, sensitive enough that the bright flash of them set alight the simmering fuse inside him.

And, because he was a gentleman, he did try to warn her. “.. caahh.. cahhdd..”

“O, don’t you dare. I know you have more control than this, just-”

He heaved his way through an ominous buildup, letting the tickle dictate the pace of his breath until it brought him to the brink. His chest inflated, pressing against Dr. Voster as she fought to the end to keep him together. She pressed hard enough that he half-wondered if his nose would bruise, but no amount of pressure could tide it back. He threw both of them forward with a sneeze scraped up from the depths of his lungs.

“HAAAZZSCHHOOOO!!-ooohhhhh..” 

His knees felt a bit weak after that one, but for the first time since he’d woken up that morning, his nose tingled with welcome relief. It would be brief, he was certain, but he’d take the reprieve while he had it. The satisfaction of the fit filled his head with a pleased emptiness as he teetered his way around the edge of the chair and dropped to sit there. He tried to catch his breath.

“Agent Omicron, I swear to god,” groused Dr. Voster. He cracked his eyes open to see her ripping out more than a dozen tissues to throw at him. “You did that on purpose.”

He gathered them up and groaned wetly into the white bouquet. His voice was an achy croak. “I had no control over that, I promise you..”

Dr. Voster washed her hands at the sink and joined him on her stool when she finished. By that time, he’d managed to make himself somewhat presentable. His suit was a bit of a lost cause, but with luck the stains would dry into something less noticeable before his flight.

“You didn’t answer my question,” she said, and there was a serious quality to her question. “Do you always sneeze like this when you catch cold?”

Omicron shook his head, bringing another bunch of tissues to his face to blow. ‘Sore throat’ may not have been an intended symptom, but it soon would be if he kept shouting sneezes on the hour. He massaged his sinuses through the thin paper, already hopelessly stuffed up as he tried to suck in a sniffle. It just made him cough.

Dr. Voster was muttering beside him. “.. may have hit you harder than intended..”

“Whad was that?” he asked. He didn’t bother masking the reproach in his tone. She sighed and adjusted her glasses.

“I said, I may have underestimated how reactive you’d be,” she admitted. “You rarely sneeze, so I thought your sinuses weren’t sensitive.”

“I have to sdneeze all the time,” Omicron admitted in turn with a sawing rub beneath his nostrils. “I’b just good at holding themb back.”

Dr. Voster stared at him a moment, then bent over her knees with a sound of pure frustration. “Omicron. You should have TOLD me that in the INTAKE INTERVIEW.”

Omicron startled in his seat, sputtering with insult. “Are you tryi’g to make this mby fault? I answered all your questions honestly!”

“I asked you if you sneeze a lot when you’re sick and you said no!!”

“Thad’s because I DON’D!” 

His throat didn’t take kindly to the treatment and he turned away to cough. He yanked out more tissues, determined to free his consonants with a noseblow. Nothing moved, and all he got was another threatening jab from the tickle for his trouble. Oh, please not again, he thought, blinking at the sensation.

“Then what do you call this, O? Are you sneezing for fun?”

Anita’s voice called him briefly back to his ire. “I almost never sneeze this much when I’m sick! In fact I sdneeze more when I’m well, I-..”

He stopped, and Dr. Voster watched him with bare worry as he wrestled with what could be another punishing sneezing fit. Omicron learned his lesson from before, and he didn’t try to fight it at all. Just gave himself over to the feverish tickling until it snagged his breath in one fell swoop.

“H-ih.. TZSshoo!” 

He waited briefly for another, but none came and Omicron could have wept with relief. That was far closer to what he’d expected at the start of this experiment. He wiped his nose with a tissue and was unsurprised to find the skin was already getting sore. His skin was prone to chafing with too much friction, which was just as inconvenient as it sounded.

Dr. Voster frowned at him. “Was that..?”

“My usual, yes,” Omicron verified with a sigh. He was numb to the embarrassment of discussing this by now.

“Okay.” Dr. Voster folded her hands in her lap and with a deep breath, marshaled herself. “Okay, okay. This.. is salvageable. I just have to create an antidote, or maybe a diluting agent, and then maybe I can administer a weaker dose before..” She glanced at her watch and hung her head in defeat. “.. you leave in less than an hour.”

Omicron gave her a half-lidded stare over his tissues. “You didn’t create an antidote?”

Dr. Voster threw her arms up and shot up from her chair to pace. “No, Omicron! No, I didn’t. It’s a cold. It’s a harmless, nose-oriented cold at that. Barely a case of the sniffles. But apparently you have the most delicate sinuses of all mankind because my dose was too strong and now you’re-”

She glanced over at Omicron to find him in a state of sneezy limbo, no longer listening as his nostrils twitched their way to a consuming finale. He stuttered a few breaths, each exhale a sound of unwitting surprise when the sneeze didn’t come. It took longer than Omicron wanted, but he finally got it.

“DZSSSH!” Another pitchy gasp, the corners of his mouth flinching upward in the barest hint of a relieved smile as he vented one down on his lap. “TSSschoo!! ahhh, tha’g you..”

Omicron wasn’t even sure who he was talking to, the tickle or his nose, but each succinct release felt wonderful and left him spent in a way that relaxed him. It seemed if he didn’t try to stop them, they would come in much more manageable waves. Hmm.. maybe that meant if he held them off, he could get another one of those punishing volleys when he needed one. It would depend on the target’s preferences.

“Omicron, are you listening?”

He glanced up to find a fretful Dr. Voster, her hair loose from her ponytail and lab coat a little askew. He sniffed. “No, sorry. What did you say?”

“I’m going to recommend we ground you,” she said. Omicron froze, uncertain if he heard right, but jumped to his feet when she snatched up her phone. “We can’t risk this compromising you.”

He tried to grab her phone from her, but she dodged. “What are you talking about? I thought that was the point.”

“The point was to give you a reliable way to sneeze,” she clarified, quickly typing something out with her thumbs. “Not make you a liabilit-HEY!”

Omicron managed to liberate her phone and held it high above to keep it out of reach as he tried to reason with her. He sniffed again when he felt his nose begin to run, and blinked against the throbbing reply of his nose-tickle. “Listen, Anita, I’ve been training for this mission for months. It’s our only chance t.. to..”

Her eyes narrowed as his fluttered. “You have to sneeze right now, don’t you?”

“Of course I do, but I’m telling you I’m hh!UHhh..” He sniffled again, fighting for composure. “.. I’m learning to work with it, alright?”

“If you can go thirty seconds without sneezing, I’ll believe you.”

Omicron swallowed. Thirty seconds yesterday would have been nothing, but today? His nostrils flared at even the suggestion. If he wasn’t certain viruses had no capacity for thought, let alone emotion, he would claim this tickle had a mind of its own and a chip on its shoulder. It was always simmering somewhere in the recesses of his sinuses, but the moment he committed to staving it off, it surged forward with pure intention.

Somehow, he could tell he’d be in for another seismic sneezing fit if he tried any tricks to keep it back, so he let his eyes fold shut. Rather than increments of jumping breaths, this sneeze was a smooth slide into fruition. He drew in a dreamy breath and felt his nostrils ease wide. Then-

“HETZChuu!” It was cleansing, a reset that cleared his mind. He welcomed another. “h-hHEH!h.. ohhH!hh..” 

The urge abandoned him, and of course the moment he wanted to sneeze, he couldn’t. Clearing his throat, he realized with a measure of chagrin that when he sneezed, he hadn’t done more than turn his head. Where had his manners gone? The urges were so immediate, he could scarcely think of anything else.

Dr. Voster snatched the phone from his hand. “That wasn’t even fifteen seconds! I’m calling HQ.”

“Anita!” he growled, and darted forward. The two of them ended up in a spontaneous spar. While Dr. Voster was rarely on the field, she was trained in hand-to-hand as well as he was. They exchanged a series of blocks, strikes, kicks, dodges, and by the time Omicron wrestled her into a hold on the linoleum, they were both breathless. Splayed out on her back, he huffed heavy breaths into her hair. The silken strands ruffled in the gusts.

She threw him a dirty look from the corner of her eye. “Let me go, Omicron.”

“Not until you let go of this notion that I’m incapable of fulfilling this mission, Anita,” he leveled back at her. “It’s unlike you to worry like this.”

Her glare darkened; she didn’t like his choice of words, but didn’t deny it. “I oversensitized you. It will be my fault if you collapse in an uncontrollable sneezing fit and get captured by the enemy.”

He scoffed. “Is that all? I didn’t sneeze once during our spar and, in case you haven’t noticed, I’ve got you in a lock on the ground. Not to mention the mission is information extraction. If I attract unwanted attention, that would be my own mistake.”

She said nothing in return, which prompted Omicron to slide off of her. Together they sat up, still sitting on the floor together. She tucked hair behind her ear, refusing to look at him. He sighed. “Anita..”

She shot him a side glance. “.. are you seriously going through with it?”

“Of course,” he replied, twitching his nose to one side. The tickle rippled, and he sniffled in response. Out of habit he reached up to rest his finger beneath. “If the target enjoys this as much as sources claim, th-h!.. then it’ll beeeeh-”

He tucked his finger more tightly to his septum, only realizing his mistake after the tickle churned restlessly against the tender, tortured edges of his sinuses. “Oh, fuck mHH-.. HIH!hh.. uhh… UH..”

Dr. Voster made a noise of exasperation and he caught the sound of tissues getting snatched from the box. As he gasped and groaned his way through another incredible buildup, a flurry of softness enveloped his squirming nose. He cupped his hand over hers as he flinched forward into their shared grip.

“iiiIHH’GGZSSCHOO!..oohhh, uhduther-..” He caught his breath in a desperate gasp, straight from the bottom of his belly. When he crunched forward, he heard a couple seams rip in his shirt. “AAHHDZZSCHOO!!”

“I guess I should said bless you,” grumbled Dr. Voster. She wiggled the tissues around his nose, which remained twitchy. He had yet to open his eyes. “Are you done?”

He shook his head.

“One more?”

He paused to consider, then nodded. And after another terrific gasp, the force of his doubling-over wrenched their hands down toward his lap. “EEHTTZZSSSCHOOO!!.. ohhh, wow..” 

Omicron nearly shivered at the pleasant, tingling aftermath. Why did they always feel so good? The bigger the better, even if they winded him. Dr. Voster left him with the tissues as he muzzily blew his nose. He kept his head down for a moment to let the dizziness ease, so he was still facing his lap when he opened his eyes.

Oh. That was new. Side effect of the virus, perhaps..? 

Omicron darted his eyes to the doctor, but she was already up on her feet and brushing off her coat. She hadn’t seen - his first and only stroke of luck today. Because if she thought his violent sneezing was grounds for calling off the mission, his sudden sneeze-induced half-chub would definitely warrant a mortifying and career-destroying advisory call to HQ. He rushed to adjust himself as she turned away, and then both of them jumped when the door opened.

“ - yes, yes, just tell them to fax it,” Agent Delta was saying, attention still focused on someone else in the hall. Omicron scrambled to his feet, standing at attention as Dr. Voster filed beside him, just as Delta turned to them both. He clapped his hands together. “Ah, there they are! Case 28947!”

That was the case number to which they were assigned, and the very case that would see Omicron leaving for the airport in the next.. his eyes flew to the clock on the wall.. twelve minutes. That’s probably why Delta was here. 

“How’s our experiment? A success?” He strolled over to Omicron, over whom he held a few inches. Omicron stood his ground, resolving not to drop his eyes when Delta jovially scanned his features. His gaze lingered on Omicron’s nose. “Looks like it was.”

“It was.” Dr. Voster and Omicron briefly locked eyes before she continued. “It’s.. functioning as intended.”

“Really?” asked Delta, impressed. Dr. Foster preened under that look, in spite of the circumstances. The senior agent looked between the two of them with a polite smile. “I suppose you wouldn’t mind me testing it as well?”

Again Omicron and Anita met eyes. This time, Omicron cleared his throat and nodded his reply. “If you wish, sir.”

Delta scratched his cheek thoughtfully, studying Omicron in silence until the shorter agent couldn’t help but sniff. He also couldn’t help the need to briefly wrinkle his nose afterward. Delta grinned.

“From how it was described, it must tickle pretty bad in there, huh?” he said, nodding to Omicron’s nose. It must be blushed pink by now, if not darker. He waited for Delta to continue, and then realized that his superior was waiting for an answer.

Much as it humiliated him to say it, he replied, “It does, sir.”

“Mmm,” Delta hummed thoughtfully, and to the man’s credit he sounded a little sympathetic. “It must feel like.. hm, how did your poetic literature put it, Doctor? What was it?.. Liiike..”

Dr. Voster, who was busy putting her hair back up into its customary ponytail, darted an apologetic glance toward Omicron. Well, it wasn’t her fault. Omicron knew what literature Delta referenced and it was only part of protocol for her to write something thorough for their records.

“Like feathers.”

“That’s right, like feathers,” Delta continued, shifting on his feet in front of Omicron. His eyes never left his subordinate’s face. “Constantly and tirelessly petting the inside of one’s nose.”

The words seemed hypnotic to Omicron because he could feel it. He could feel those feathers, stroking so gently and repeatedly against the far depths of his sinuses. Somewhere deep, somewhere too far to scratch. They were careful with the fragile nerves there, but dauntless in their purpose. To make him sneeze. And sneeze.. And sneeze…

Omicron’s eyes fluttered shut, his breath deepening as his nostrils flared softly to the siren call of those thoughts. His hands remained firmly clasped behind him.

Delta continued as if he didn’t notice. “Yes. An ever-present irritation in the most sensitive depths, coaxed to greater and greater strength by your breath. Isn’t that ironic? That you yourself are the catalyst to this growing fire inside you, cursed to fan the flames even in sleep.”

Did it start while I was asleep last night? Omicron wondered. Because when he woke, it was to an itchy nose. So itchy in fact he snorted, sniffed, and rubbed it with such single-mindedness he nearly forgot he was due to Dr. Voster’s lab today. He breathed now, a slow and reverent inhale that squeaked around his blocked sinuses and added speed to the stroking sensation of those silken feathers.

His lips parted, his chest jumping with a sudden breath. He sighed it out, the ghost of a moan carried on his exhale.

“And once it starts, it is nigh impossible to stop. That tickle won’t let you. No matter how badly you might want a reprieve, those feathers are mindless. You can’t reason with them. They’ll just keep at their work, teasing and teasing that aching flesh until..”

The tickle buoyed him through a catching gasp. Omicron sighed again, his voice carrying, wanting. Another cresting gasp, the wave of something reachable, and then he fell short again. His nostrils pulsed plaintively, begging what dwelled inside to give him relief. But Omicron didn’t mind this limbo, this torture. He knew what came after would be well worth the wait.

“.. agitating.. working you over.. beckoning you with a relentless tickle.. until you can take it no longer.”

His chest swelled, and what he thought might be another forsaken gasp turned into the exclamation of climax. “HAH-.. BBZSSSSCHHUUHH!”

The first one came, because of course there would be more, and he snatched an arm around his middle when there was a strong, delicious undulation of pleasure deep in his gut. He groaned, his voice deep and gravelly and unfamiliar to his ears.

“Whoa!” came Delta’s exclamation. He sounded shocked. “That sure was something. Omicron, bless-”

“HEH-.. BBZSSSHHOO!.. nnnnghh.” 

These were smooth as butter - one big, long, scooping breath and then a knee-shaking release. He sniffled thickly, wetly, with his eyes shut in concentration. Omicron wanted another, and this time the tickle delivered. Those invisible feathers rustled like wheat in a windstorm, and he caught himself grinning as he gasped another huge breath. 

“HHHH!.. EHDZZSSSHUUE!!”

He swayed forward as another cramp of ecstasy swirled in his gut, and Omicron felt a strong hand brace his shoulder to keep him from tipping over.

“Is he okay?” was one faint voice.

“Yes, just-” came another.

Omicron sneezed.

“HIIH!.. IIHTDZZSSSHHHTT!! .. fuck.”

That one was particularly wet, fired haphazardly at the floor like the rest. It also contracted in a burst of stars behind his groin so intense that Omicron became instantly and fearfully aware that he would actually come in his pants if he kept this up. And holy shit he didn’t want that to happen. Not here. Not now. 

He jerked his free hand out, holding it expectantly toward the voices. With tremendous effort, he tried to be understood. “Tiih.. Tiizzusss.. HUH-”

“One second, one second!!” he heard Anita’s tempering assurances over the rush of blood in his ears. 

And the rush of ticklish sensation through his nose. He couldn’t get the visual of feathers out of his head. Delta, damn him. All Omicron could see behind the dark of his wet eyelids was a field of pristine, white, downy feathers positioned diabolically against every inch of his nasal walls. The tips of them wavered each time he hitched a stuttery inhale, and huffed a helpless exhale. They were devoid of life beyond that which he gave them, breathing intent into them as they swayed against swollen, irritated flesh. He could picture his nasal membranes flinching helplessly against the onslaught, crying out to him for relief. And he would give it-

“hH-.. uHH’TZZZSSSHHOOOO!!”

The feathers fluttered wildly and his nose calmed with a prickling balm, sated. Until he sniffled against the slogging block of congestion in his nose and what little air there was eeked through and-.. the feathers trembled, dragging their soft tips gingerly against his quivering flesh, an endless torment, so subtle yet compounding in its simplicity because he could feel the echoes of that tantalizing sensation all through his nose and as he snuffled against the feeling, the feathers trembled again as if in eagerness, excitement, their tendrils tracing long worn paths on fraught nerves as the aching pressure built and built in his nose, deep inside, and oh-.. ohh-

“hHHHHH-”

“Oh no you don’t.” 

The sudden presence of a hand over his nose surprised him, frightened the sneeze away, and Omicron felt an irrational pang of frustration when his gasp escaped from him with a gutteral hhuhh unrelieved. He realized in retrospect that the voice was Dr. Voster, and the hand belonged to her too. He also realized, in a wash of cold sweat, that he was achingly hard where his prick was tucked into his belt.

“Blow your nose, Omicron.”

He struggled to comply. A hitching breath got out of his control, only emboldening the tickle, and again he thought of the feathers. They were everywhere, impossible to blow out, and they’d just keep… keep-

“RRZZSSSSCHH’HOO!”

It tore out of him with a passion, and the pleasure washed over him so fiercely he would have gone to his knees had Delta not stepped in to catch him. Omicron panicked, bursting into motion to put distance between himself and the others. They let him go, only for him to stumble backwards onto his ass. The impact shook an impending sneeze out the queue, and Omicron had a moment to collect his bearings.

He quickly got to his hands and knees, trying to keep his crotch pointed to the floor. He was still painfully hard, but thankfully he hadn’t managed to sneeze himself into orgasm. Now that he had his wits, he realized he still had the wad of tissues in his hand. He brought them to his face and blew as hard as he could, concentrating only on the act of getting something out rather than thinking too hard about what was happening inside.

Adrenaline and humiliation were quick and quiet boner killers; any residual arousal swirling in his thoughts extinguished as he assessed his situation. He was somewhat sweaty, stained with a few of his own sneezes, and his damn nose still tickled. Omicron threw caution to the wind and rubbed it with fast, punishing pressure against his septum, as if to admonish it. Rather than chance a sniffle, he breathed only through his mouth as he climbed to his feet.

Both Dr. Voster and Agent Delta regarded him warily. Omicron straightened his vest, his jacket, and smoothed back his hair where it had fallen into his eyes. 

“Pardod be,” he rasped, still breathless. He coughed into his fist to clear his throat.

Delta’s features eased into genuine concern. The man’s flippant nature notwithstanding, he did care about his people. “Agent, are you alright?”

“Of course,” insisted Omicron. He cleared his throat again. “Just fine. Why?”

“Well, that just..” Delta looked over to Dr. Voster, who was refusing to meet anyone’s eyes. “.. it seemed very intense, don’t you think? Doctor?”

The doctor startled at her name, then reached to adjust her glasses. She looked now at Omicron, her expression as hard and firm as her voice. “Yes, I agree. And I would recommend..”

Here, Omicron bit his tongue. If Anita really did want to rat him out, he’d only dig his own grave if he tried to deflect. But then her eyes softened.

“.. that Agent Omicron desist from triggering the suggestion impulse until this initial sensitivity wears off.”

Tension left his shoulders. He closed his eyes briefly in relief.

Delta rubbed the back of his neck, contrite. “Oh. Sorry, I didn’t realize it was an issue. You should have told me!”

“I wasn’t aware it was a pattern until you tried it, sir,” said Dr. Voster. She crossed her arms and nodded toward Omicron. “And with all due respect, sir, you should really apologize to Agent O.”

Delta turned to him with dewy puppy-dog eyes and Omicron wanted to evaporate out of embarrassment. He didn’t do well with anything sentimental and at times his superior was pure sentimentality. “Forgive me, Omicron. I hope I didn’t cause you any distress. I’m sure that wasn’t comfortable.”

On the contrary, thought Omicron, but admitting anything even close to the truth made his tongue wither. His cheeks burned, and to add further indignity, he sniffled. The brief, tickling swell prompted him to thumb the end of his nose to encourage good behavior. 

“Not at all, sir. Please don’t trouble yourself over it.”

Delta clapped him companionably on the shoulder, and when he turned toward Dr. Voster, Omicron leaned around him to throw a scathing look her way. She only smiled. That prompted apology was likely just her getting some revenge. To be frank, the new complication of sneeze-induced arousal would absolutely complicate the mission, but Omicron begged to be given a case like this for months. More than a year, even. He’d take the risk rather than give this up.

Besides, it wasn’t his fault his nose couldn’t calm down. He didn’t conduct a half-baked intake interview and design an overpowered tickle virus, so why should he be the one to suffer the consequences? Beyond those he was already suffering, he supposed.

Once again, thinking too much about it summoned the tickle forth. Omicron refused to get stuck in another self-perpetuated sneeze-cycle, so he focused only on the wall as the urge lapped at the edges of his sinuses. Oh, the ones that made him wait were the worst.

“.. to it that we grab your luggage on the way to the jet,” Delta was saying. He still had his hand on Omicron’s shoulder and squeezed when he got no response. “You already packed right?”

Omicron took a breath to reply, but it hitched in his throat. Then rushed out with a soft uhh that he couldn’t suppress. Gone were the days when he could quietly build up to a sneeze; it seemed this virus wanted everybody to know as soon as his nose started to tickle. He fought to keep his eyes open, and his ears from flushing red.

“.. yeh..hssirr..”

Delta’s smile tilted back into concerned territory, and he rubbed Omicron’s shoulder. “Looking a little sneezy, Agent. Try not to knock yourself down this time.”

Omicron huffed a laugh that trembled into a gasping inhale, a fitful exhale, an even more urgent inhale-.. “-uUHH!” and then left him on a frustrated sigh. He rubbed his face with both hands. “Fuck,” he mumbled. Then his head shot up in alarm. “Oh-.. ah, sir-...”

Agent Delta only laughed, booming and cheerful as he slid his arm further across Omicron’s shoulders to give him a jostling side-hug. “Don’t worry, Agent. These are extenuating circumstances, I’ll let that it slide.”

Omicron nodded as he was jerked around by Delta’s strength, reaching up to push his hair back when it fell out of style again. His nose was still tingling, unrelieved, and he scrunched it with exasperation. Sneeze or don’t sneeze, won’t you? 

“Off we go!” crowed Delta, escorting Omicron toward the door while still under his arm. He looked back to Dr. Voster. “I’ll be with him on the flight, so we’ll let you know if there are any case developments.”

He tightened his hold when he said this, and Omicron fought down a flash of annoyance that Delta probably meant any developments with Agent Omicron’s nose. Speaking of which… 

Omicron let his eyes roll shut as Delta led him into the hall, their footsteps echoing down the corridor. He was saying something, probably about the jet, but Omicron let the words wash over him just as he let the tickle wash through his nose. Wary of what might happen, he strayed away from thinking too much about feathers. Instead, he thought of dust motes. A dandelion seed. Something small and irritating and hopelessly stuck somewhere deep inside him. Whatever it was, this thing wanted to escape. It squirmed and twisted, fluttered its wings or flicked its tail. The throbbing urgency of Omicron’s tender pink membranes wouldn’t deter it, neither would the gradual unsteadiness of his breath. He exhaled, yearning.

“..uh-..”

The invader redoubled its efforts, writhing against his most sensitive places. He couldn’t-.. he..

“.. huhh-..”

If only he could reason with it, but on a baser level, Omicron didn’t want to. He wanted it to flap and struggle, tickle and itch, uncontrollable and impossible to satiate. Fan the flames of this urge so feverish that he couldn’t do anything but-

“HAH-!”

Omicron found himself smiling again, delirious as he breathed into this unstoppable force. He was completely helpless to its thrall. This thing in him, nuzzling and ruffling and bothering his nose so fervently, dotingly, sweeping him up with its caress. He.. oh-.. oh-!

“S’combi’g-” He gasped out, if only just to himself. The breathy word preceded an absolutely euphoric sneeze. “WRIZZSSSSHUUU’uoohhhh…”

Omicron stayed as he was, one hand cupped to his nose and the other bracing his middle. Another dagger of pleasure had stabbed him through, but it was fast to dissipate as he sniffled into his palm. The way his nose tingled signaled a temporary relief. Omicron couldn’t decide if he was disappointed by this or not.

“Goodness, bless you!” Omicron jumped. Delta stood beside him, both hands in his pockets now, looking amused. Omicron had forgotten he was there. “That was a big one! Sounds like you worked your way up to it.”

Why was Omicron cursed with the chattiest superior Agent in the force? He snuffled again behind his hand, by habit searching his pockets for a handkerchief or a restaurant napkin, anything. He paused when Delta extended a travel pack of tissues. 

“Thought you might need these, so I brought a few packs along.”

“.. Tha’g you.” 

Omicron took it with grace, turning around so he could use both hands. He blew his nose yet again, dismayed with the sheer amount of moisture he was capable of producing. At this rate he’d need to stay hydrated. Once he finished up, he turned back to Delta to find him extending a small bottle of hand sanitizer. He eyed the other man.

“You can’t actually catch this, sir.”

“I know, Agent, but the public won’t know that,” he said, as carefree as ever. “And even if you’re not actually sick, better to keep your hands clean, mm? And maybe try the vampire trick too.” Here he demonstrated by lifting his elbow and tucking his nose in. 

Omicron burned with the embarrassment of having his lackadaisical sneezing addressed in such an obvious way. Normally he was very thorough with his hygiene practices. He sneezed into his elbow or better, a handkerchief if he had one. He washed his hands frequently and properly. Something about this tickle just emptied his head of all sense when it came over him. It was a miracle he’d managed to even cup a hand to his mouth just now. He didn’t remember doing that.

So he could only nod, his cheeks burning, as he took the bottle and copiously applied. The stringent scent bloomed in the air. Delta could probably tell he was upset because he gave the shorter agent a lighthearted slap on the back. “You’re usually very conscientious. Just a gentle reminder, agent.”

Omicron nodded again, this time with a yip of surprise as his eyes slammed closed. Suddenly his nose was frenzied, filled to the brim with that strong, alcoholic smell. It burned, so sharp it brought tears to his eyes as he rushed his elbow to his face. Unlike the other sneezes of this morning, this itch wasn’t indulgent. It was almost brutal. 

“Chssh-! Tschh!” Even without muffling into his jacket, they would have been small. Smaller than his normal sneezes, even. They were fittish, barely letting him up for air. “Itschh! HHtschh!.. uh-.. TSSH’hee!!.. fucking hell..”

It only lasted seconds, over as suddenly as it began, and Omicron picked his head up blearily. He sniffled, coughing again at the remaining scent on his hands as he fished out another tissue and nursed his nose. Stupid thing was so needy now, he couldn’t even use hand sanitizer without a complaint. Belatedly he realized he’d cursed in front of his superior again.

When he looked at Delta, the man was regarding him thoughtfully. Not his usual fond musing sort of look either. The kind of discerning expression that awarded him the rank he currently held. Omicron’s blinked at him, wide eyed over the edge of his tissues.

“S-Sorry for sweari’g, sir..”

Delta stirred from wherever he’d been, and dropped into a polite smile. It didn’t quite reach his eyes. “That’s alright, Omicron, I honestly don’t mind. But, I’ll ask this again: are you alright?”

Omicron blinked at him again, owlish. “Me, sir?”

Delta chuffed an airy chuckle. “Yes, agent, you. You’re sure this..” He warred over his words, trying to pick the best ones. “I know you’ve been waiting a long time for this opportunity, but are you sure? About this?”

Omicron bristled, and he was certain Delta could tell. He finished up with his nose, balling up the tissue and foregoing hand sanitizer this time. “Respectfully, why wouldn’t I be sure, sir?”

“This science isn’t exact,” Delta told him. His voice was lower now, the proper tone of a superior officer. “Dr. Voster is a genius, but this is the first time we’ve tried something like this. There’s bound to be a margin of error. So I’m asking you again, Agent Omicron..” Here he fixed his subordinate with a firm stare. “.. are you sure about doing this right now, as you are, in this state?”

Omicron didn’t have to think about it. He merely drew himself up to a force-standard posture and looked Delta in the eyes without flinching. “Yes, sir. Very sure.”

Delta held his stare, but when Omicron didn’t buckle, he sagged where he stood. With a long sigh, he once again patted Omicron’s shoulder. “Alright, agent. But if you change your mind or if you become compromised, you must be honest and tell me immediately. Am I understood?”

Omicron just barely managed to resist twitching his nose; he could feel it wanting attention, but didn’t want to give Delta any reason to doubt him. “Of course, sir.”

Delta gave him a jaunty thumbs up, back to his usual lofty cheer. “Grand! I’ll take you at your word.” He turned away, beginning to stride down the corridor with expectation Omicron would follow. “Now, we ought to get a move on. They’ve got the jet idling and you know how they are about the fuel budget..”

Agent Delta carried on, blind to his subordinate keeping step behind him. Omicron absently, then more purposefully, rubbed his nose. The skin was starting to sting, no doubt ready to peel by tomorrow like sunburn. The tickle stretched languidly, lazily working Omicron up to another toe-curling sneeze. The hedonist in him wanted to welcome it.

However, he had nearly twelve hours on a jet to contend with, surrounded by other personnel. And he was certain now after that little conversation with Delta that the man would be watching Omicron carefully from here on out. If he noticed anything suspicious, he’d ground the mission and take Omicron off the case without remorse. He couldn’t let it happen, not after how hard he’d fought for this.

His nostrils flared against his finger, a premature warning to what was brewing. But Omicron knew, and he was prepared for the impending battle. It wouldn’t be easy, but he fully intended to negotiate with his nose and keep sneezing to nil on the flight. Almost nil, if he couldn’t hold out. Again his nostrils flared, as if playfully chiding him. You’re not in control, his nose seemed to say. I am.

Well, thought Omicron as he stepped out of the jet bay and into the sunshine. The jet sat waiting on the tarmac, a flurry of activity around it. We’ll just see about that.

/tbc??

I’m not sure if I’ll continue it, but I hope you had fun reading!! Part 2 is in the works!

PART 2 IS HERE!

[mindblowingscience]

The virus that causes COVID-19 has been very good at mutating to keep infecting people – so good that most antibody treatments developed during the pandemic are no longer effective. Now a team led by Stanford University researchers may have found a way to pin down the constantly evolving virus and develop longer-lasting treatments. The researchers discovered a method to use two antibodies, one to serve as a type of anchor by attaching to an area of the virus that does not change very much and another to inhibit the virus’s ability to infect cells. This pairing of antibodies was shown to be effective against the initial SARS-CoV-2 virus that caused the pandemic and all its variants through omicron in laboratory testing. The findings are detailed in the journal Science Translational Medicine. “In the face of an ever-changing virus, we engineered a new generation of therapeutics that have the ability to be resistant to viral evolution, which could be useful many years down the road for the treatment of people infected with SARS-CoV-2,” said Christopher O. Barnes, the study’s senior author, an assistant professor of biology in the Stanford School of Humanities and Sciences and a scholar at Stanford’s Sarafan CheM-H.

Continue Reading.

[facts-i-just-made-up]

What is the greatest of all speculative fiction novels?

What makes a novel great is very subjective. Dune and 1984 are among the most famous, Frankenstein is often credited with inventing the genre, and Valhalla is the top favorite novel of nearly four people. It's also half off from the publisher right now.

But most people familiar with "Far Beyond the Machine" by Rudy T.F. Cloutier agree that if nothing else, it is the novel that best predicted the future. Written in 1972, it depicts the then-distant future of 2022 where the world population is passing 8 billion people and a virus called "The Omicron" is wreaking havoc across the globe. Meanwhile, the USSR has broken up and Russia has declared war on Ukraine.

The plot is a fairly typical spy story in which the heroic Agent 909 has been tasked with recovering a hard drive with critical information about the Russian plans. Surprisingly for a 1972 novel written when a 1MB hard drive weighed several pounds, the drive in the novel is stated to hold 16GB but is only the size of a thumbnail.

Most surprisingly, the novel features the use of "Motorolas," in reference to the then upcoming, just-announced 1973 release of the first public mobile phone. In the world of Cloutier's 2022, these are described not as giant cordless beasts like the real thing, but as tiny handheld computers that can look up any information in the encyclopedia, give directions to a safe-house, take and send photos, and even in once scene, access a computer-dating service.

Though the book is celebrated for its exceedingly prophetic vision of 2022, its sequel was not at all well received, with critics claiming its vision of 2026 as a post-apocalyptic wasteland where rich fascists have seized America and condemned its citizens to slavery and death for their own financial gain was too depressing, and the new main character Agent 020 was derided as a "Mary Sue."

[mariacallous]

Updated vaccines against Covid-19 are coming, just as hospitalizations and deaths due to the virus are steadily ticking up again.

Today, the US Food and Drug Administration authorized new mRNA booster shots from Moderna and Pfizer, and a panel of outside experts that advises the Centers for Disease Control and Prevention voted to recommend the shots to everyone in the United States ages 6 months and older. Once Centers for Disease Control and Prevention director Mandy Cohen signs off on the recommendations and the vaccines are shipped, people can start getting the boosters.

The recommendation is projected to prevent about 400,000 hospitalizations and 40,000 deaths over the next two years, according to data presented at the meeting by CDC epidemiologist Megan Wallace.

This year’s mRNA vaccines are different from the 2022 booster in a key way. Last year’s shot was a bivalent vaccine, meaning it covered two variants: the original one that emerged in China in 2019, plus the Omicron subvariant BA.5, which was circulating during much of 2022. This fall’s booster drops the original variant, which is no longer circulating and is unlikely to return. It targets just the Omicron subvariant XBB.1.5, which was dominant throughout much of 2023.

Pfizer and Moderna’s vaccines work by introducing a tiny piece of genetic material called messenger RNA, or mRNA, that carries instructions for making SARS-CoV-2’s characteristic spike protein. Once it is injected, cells in the body use those instructions to temporarily make the spike protein. The immune system recognizes the protein as foreign and generates antibodies against it. Those antibodies stick around so that if they encounter that foreign invader again, they will mount a response against it.

Since the start of the Covid-19 pandemic, the virus has acquired new mutations in its spike protein and elsewhere. These mutations result in new variants and subvariants that diverge from the original virus. When enough mutations accumulate, these new versions can more easily evade the antibodies created by previous vaccine doses or infections.

The constantly evolving nature of the virus is the reason health regulators decided last year to update the original mRNA vaccines, which were designed against the version of the virus that first appeared in 2019. This year, once again, the virus has changed enough to warrant an updated booster.

In June, an advisory committee to the FDA recommended that this fall’s booster be a monovalent vaccine—targeting only the then-dominant XBB.1.5 subvariant.

At that meeting, committee members reviewed evidence suggesting that the inclusion of the original variant may hamper the booster’s effectiveness against newer offshoots. “The previous bivalent vaccine contained the ancestral spike and thus skewed immune responses to the old spike,” says David Ho, a professor of microbiology at Columbia University whose research, which is not yet peer-reviewed, was among the evidence the FDA panel reviewed. “This is what we call immunological imprinting, and it results in lack of immune responses to the new spike.” He thinks taking out the old variant should optimize the immune response.

But over the past few months, even newer Omicron offshoots have arrived. Currently, EG.5.1, or Eris, is the dominant one in the United States, United Kingdom, and China. Meanwhile, a variant called BA.2.86, or Pirola, has been detected in several countries. Pirola has raised alarm bells because it has more than 30 new mutations compared to XBB.1.5.

Even though the new boosters were formulated against XBB.1.5, they’re still expected to provide protection against these new variants. “The reason is, while antibodies are important in protection against mild disease, the critical part of the immune response that’s important for protecting against severe disease is T cells,” says Paul Offit, a professor of vaccinology at the University of Pennsylvania and member of the FDA’s vaccine advisory committee.

These cells are a different part of the immune response. Unlike antibodies, which neutralize a pathogen by preventing it from infecting cells, T cells work by eliminating the cells that have already been invaded and boosting creation of more antibodies. Both the Moderna and Pfizer-BioNTech Covid vaccines produce long-lasting T cells in addition to antibodies.

It’s why, Offit says, when the Omicron wave hit in late 2021 and peaked in January 2022, the US didn’t see a dramatic increase in hospitalizations and deaths even as cases rose significantly: People’s T cells kicked into gear, even when their antibodies didn’t recognize the Omicron variant.

“In some ways,” says Offit, when it comes to vaccine booster development, “it almost doesn’t matter what we pick to target” because the coronavirus has yet to evolve away from T cell recognition. “Everything works.”

Scientists think T cells are able to protect against severe Covid because they’re recognizing parts of the virus that have remained unchanged throughout the pandemic. “I suspect that as we continue to vaccinate, there are some conserved regions [of the virus],” says Jacqueline Miller, Moderna’s head of infectious diseases. “So even with the accumulation of mutations, we’re still building on previous immunity.”

People who have hybrid immunity—that is, have had a Covid infection and have also been vaccinated—seem to have the best immune responses to new variants, she says, which suggests that previous exposure shapes and improves immune responses to new variants. Preliminary studies show that antibodies generated by previous infections and vaccinations should be capable of neutralizing Pirola.

Earlier this month, Moderna issued a press release saying that clinical trial data showed that its updated booster generated a strong immune response against Pirola, as well as the more prevalent Eris variant.

In a statement to WIRED, Pfizer spokesperson Jerica Pitts said the company continues to closely monitor emerging variants and conduct tests of its updated monovalent booster against them. Data presented at Tuesday’s CDC meeting showed that Pfizer-BioNTech’s updated booster elicited a strong neutralizing antibody response against both Eris and Pirola.

The FDA expects that Covid-19 vaccines will continue to be updated on an annual basis, unless a completely new variant emerges that requires a different approach. “We will always be a little behind the virus,” says Ho. “In this instance, we won’t suffer too much, but that might not be the case going forward. Surveillance is imperative.”

[wahyugunawanpbb]

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[literaryvein-reblogs]

Hello! First of all, thank you for the wonderful content! It's a real joy, and an enrichment, food for both the brain and the heart! I was wondering if through your treasures, you could find some writing notes/words/concepts/vocabulary relating to genetic engineering? Like...creating a virus, and a vaccine for it, modifying the virus so it has certain specific effects.... Thank you in advance!

Writing Notes: Virus & Vaccine

References How Viruses Work; Replication Cycle; Mutation, Variants, Strains, Genetically Engineering Viruses; Writing Tips; Creating your Fictional Virus & Vaccine

Virus - an infectious microbe consisting of a segment of nucleic acid (either DNA or RNA) surrounded by a protein coat.

It is a tiny lifeform that is a collection of genes inside a protective shell. Viruses can invade body cells where they multiply, causing illnesses.

It cannot replicate alone; instead, it must infect cells and use components of the host cell to make copies of itself. Often, a virus ends up killing the host cell in the process, causing damage to the host organism.

Well-known examples of viruses causing human disease include AIDS, COVID-19, measles and smallpox. Examples of viruses:

Viruses are even smaller than bacteria and can invade living cells—including bacteria. They may interfere with the host genes, and when they move from host to host, they may take host genes with them.

Bacteriophages (also known as phages)—viruses that infect and kill bacteria.

Size differential between virus and bacterium

Viruses are measured in nanometers (nm).

They lack the cellular structure of bacteria, being just particles of protein and genetic material.

How Viruses Work

Viruses use an organism’s cells to survive and reproduce.

They travel from one organism to another.

Viruses can make themselves into a particle called a virion.

This allows the virus to survive temporarily outside of a host organism. When it enters the host, it attaches to a cell. A virus then takes over the cell’s reproductive mechanisms for its own use and creates more virions.

The virions destroy the cell as they burst out of it to infect more cells.

Viral shedding - when an infected person releases the virus into the environment by coughing, speaking, touching a surface, or shedding skin.

Viruses also can be shed through blood, feces, or bodily fluids.

Virus Replication Cycle

While the replication cycle of viruses can vary from virus to virus, there is a general pattern that can be described, consisting of 5 steps:

Attachment – the virion attaches to the correct host cell.

Penetration or Viral Entry – the virus or viral nucleic acid gains entrance into the cell.

Synthesis – the viral proteins and nucleic acid copies are manufactured by the cells’ machinery.

Assembly – viruses are produced from the viral components.

Release – newly formed virions are released from the cell.

Mutations, Variants, and Strains

Not all mutations cause variants and strains. Below are definitions that explain how mutations, variants, and strains differ.

Mutation - errors in the replication of the virus’s genetic code; can be beneficial to the virus, deleterious to the virus, or neutral

Variants - viruses with these mutations are called variants; the Delta and Omicron variants are examples of coronavirus mutations that cause different symptoms from the original infection

Strains - variants that have different physical properties are called strains; these strains may have different behaviors or mechanisms for infection or reproduction

Genetically Engineering Viruses

Using reverse genetics, the sequence of a viral genome can be identified, including that of its different strains and variants.

This enables scientists to identify sequences of the virus that enable it to bind to a receptor, as well as those regions that cause it to be so virulent.

Vaccine - a special preparation of substances that stimulate an immune response, used for inoculation

Vaccines & Fighting Viruses with Viruses

Common pathogenic viruses can be genetically modified to make them less pathogenic, such that their virulent properties are diminished but can still be recognized by the immune system to produce a robust immune response against. They are described as live attenuated.

This is the basis of many successful vaccines and is a better alternative than traditional vaccine development which typically includes heat-mediated disabling of viruses that tend to be poorer in terms of immunogenicity.

Viruses can also be genetically modified to ‘fight viruses’ by boosting immune cells to make more effective antibodies, especially where vaccines fail. Where vaccines fail, it is often due to the impaired antibody production by B-cells, even though antibodies can be raised against such viruses – including HIV, EBV, RSV & cold-viruses.

Related Articles: Modified virus used to kill cancer cells ⚜ Genetic Engineering ⚜ Engineering Bacterial Viruses ⚜ Benefits of Viruses

A Few Writing Tips

As more writers look to incorporate infectious diseases into their work, there are quite a few things writers should keep in mind:

Don’t anthropomorphize. Really easy to do, but scientifically wrong. Viruses don’t want to kill you; bacteria don’t want to infect you; parasites don’t want to make your blood curdle. None of these things are big enough to be sentient to want to do anything. They just do it (or don’t do it).

Personal protective equipment. This includes wearing gloves, lab coats, safety glasses, and tying your hair back if it’s long. It is the same as Edna Mode’s “no capes.” Flowing hair looks cool all the way to the explosive ball of flames that engulfs someone’s head.

Viruses are small. You can’t see viruses down a normal microscope—they need a special microscope called an electron microscope. These are highly specialized and take a long time to make the preparations to be able to see the virus. Normally viruses are detected by inference—measuring part of them using an assay that can amplify tiny amounts of material, for example PCR.

Viruses don’t really cause zombie apocalypses. 

Vaccines work. But they take time. The best vaccine in the world will still only prevent infections two weeks after it is given. Drugs are quicker, but still take some time. But the good news is an infection is not going to kill you (or turn you into a zombie) quickly, so they both have time to work.

Scientists use viruses as a vector to introduce healthy genes into a patient’s cells:

Your Fictional Virus & Vaccine

When creating your own fictional virus, research further on the topic and consider choosing a specific one as your basis/inspiration.

Here's one resource. For some of them, you'll need a subscription to access, but those that are available give you a good overview of the virus, as well as treatment options.

You can do the same for creating your fictional vaccine:

Here's one resource. And here's one on vaccine developments.

Sources: 1 2 3 4 5 6 7 8 9 10 11 12 13 ⚜ Writing Notes & References

Lastly, here's an interesting article on how science fiction can be a valuable tool to communicate widely around pandemic, whilst also acting as a creative space in which to anticipate how we may handle similar future events.

Thanks so much for your kind words, you're so lovely! Hope this helps with your writing. Would love to read your work if it does :)

[reasonsforhope]

I'm sorry I'm sending so many asks. I've been struggling like this for a year now, and it's barely gotten easier, but you've often been a good help with my anxiety. I really appreciate everything you do. It's hard to have hope.

I've had a really bad moment again recently. I have to be honest, the worst thing, that makes me the most anxious out of everything else, is COVID. Because it feels like nobody is paying attention, and that there is no good news. There is never any good news. COVID is always the catalyst for the worst of my anxious slumps. It's really bad. COVID is very, very scary. If you somehow have anything for that, I'd be thankful. Often I've only been able to set my heart on nasal vaccines, or next gen vaccines in general, but they're not going fast enough whatsoever.

I'm sorry, again. I don't want to try and treat you like a therapist. I just trust you. If this is too overwhelming, you can just delete it, but if you do, I'd like to know. Just so I'm not waiting for it to be answered.

I just ravaged through someone's doomy collapse blog, again, after stumbling on it in my rising anxiousness, and it was not good. I think I'm clearly too open-minded of a person to some degree, and I feel so pulled around by information that I see. I don't want to be placated, out of the loop, or lied to, but I don't want to feel hopelessly depressed. Everything is too complex. I feel like I've been through this maze, top to bottom, over and over again, and again. I just wish I knew how much truth their words held, or anyone else's words held.

And I wish we were all masking, at the very least. I'm holding myself back from swearing. I don't know if you'd have a good way to counteract general "collapse" thoughts, either. But that's also a thing.

<3 I'm touched by your trust.

I just found some good news about COVID - the first genuinely good covid-related news article I've seen in a while, instead of all of the "ah but young abled people are fine!" bs - and remembered this ask.

"As new varieties of the coronavirus took center stage during the COVID-19 pandemic, the odds of developing long COVID dropped. Those who were vaccinated against the virus saw the biggest plunge over time.

For every 1,000 unvaccinated people, 104 developed long COVID up to one year after an infection during the pre-delta phase of the pandemic. That fell to 95 per 1,000 during the delta variant’s era and 78 during omicron’s reign. Among vaccinated people, just 53 out of 1,000 developed long COVID up to a year after infection during delta and only 35 during omicron, researchers report July 17 [2024] in the New England Journal of Medicine.

The study of U.S. Department of Veterans Affairs Health Care System data looked at people who had a COVID infection from March of 2020 — the month the pandemic began — to the end of January in 2022. The researchers, from the Veterans Affairs St. Louis Health Care System, compared the rates of long COVID during three phases of the pandemic among those who had and had not gotten vaccinated...

A comparison of omicron infections with infections from prior eras found that 72 percent of the drop in the long COVID rate during omicron was attributable to vaccines. The remainder was due to changes in the virus and improvements in medical care and the use of antiviral treatments during the omicron phase.

Even with the steep decline in the occurrence of long COVID for vaccinated people, there is still a risk, the researchers write. With “the large numbers of ongoing new infections and reinfections, and the poor uptake of vaccination,” they continue, this “may translate into a high number of persons” with long COVID."

-via ScienceNews, July 17, 2024

--

Masking continues to be important. The virus continues to be a problem. But especially given the decline in masking, I'm really encouraged to see this news. Because long covid IS scary. And I'll take any good news on this front that I can get.

It's especially encouraging because it shows how much staying on top of your vaccinations really does matter and really can prevent long covid.

I'm also really hopeful (though I don't have a related background and have no idea how realistic my hopes are) that this trend has been continuing past the end of the study (2022).

[covid-safer-hotties]

FDA Approves and Authorizes Updated mRNA COVID-19 Vaccines to Better Protect Against Currently Circulating Variants - Published Aug 22, 2024

Today, the U.S. Food and Drug Administration approved and granted emergency use authorization (EUA) for updated mRNA COVID-19 vaccines (2024-2025 formula) to include a monovalent (single) component that corresponds to the Omicron variant KP.2 strain of SARS-CoV-2. The mRNA COVID-19 vaccines have been updated with this formula to more closely target currently circulating variants and provide better protection against serious consequences of COVID-19, including hospitalization and death. Today’s actions relate to updated mRNA COVID-19 vaccines manufactured by ModernaTX Inc. and Pfizer Inc.

In early June, the FDA advised manufacturers of licensed and authorized COVID-19 vaccines that the COVID-19 vaccines (2024-2025 formula) should be monovalent JN.1 vaccines. Based on the further evolution of SARS-CoV-2 and a rise in cases of COVID-19, the agency subsequently determined and advised manufacturers that the preferred JN.1-lineage for the COVID-19 vaccines (2024-2025 formula) is the KP.2 strain, if feasible.

“Vaccination continues to be the cornerstone of COVID-19 prevention,” said Peter Marks, M.D., Ph.D., director of the FDA’s Center for Biologics Evaluation and Research. “These updated vaccines meet the agency’s rigorous, scientific standards for safety, effectiveness, and manufacturing quality. Given waning immunity of the population from previous exposure to the virus and from prior vaccination, we strongly encourage those who are eligible to consider receiving an updated COVID-19 vaccine to provide better protection against currently circulating variants.”

The updated mRNA COVID-19 vaccines include Comirnaty and Spikevax, both of which are approved for individuals 12 years of age and older, and the Moderna COVID-19 Vaccine and Pfizer-BioNTech COVID-19 Vaccine, both of which are authorized for emergency use for individuals 6 months through 11 years of age.

What You Need to Know

=Unvaccinated individuals 6 months through 4 years of age are eligible to receive three doses of the updated, authorized Pfizer-BioNTech COVID-19 Vaccine or two doses of the updated, authorized Moderna COVID-19 Vaccine.

=Individuals 6 months through 4 years of age who have previously been vaccinated against COVID-19 are eligible to receive one or two doses of the updated, authorized Moderna or =Pfizer-BioNTech COVID-19 vaccines (timing and number of doses to administer depends on the previous COVID-19 vaccine received).

=Individuals 5 years through 11 years of age regardless of previous vaccination are eligible to receive a single dose of the updated, authorized Moderna or Pfizer-BioNTech COVID-19 vaccines; if previously vaccinated, the dose is administered at least 2 months after the last dose of any COVID-19 vaccine.

=Individuals 12 years of age and older are eligible to receive a single dose of the updated, approved Comirnaty or the updated, approved Spikevax; if previously vaccinated, the dose is administered at least 2 months since the last dose of any COVID-19 vaccine.

=Additional doses are authorized for certain immunocompromised individuals ages 6 months through 11 years of age as described in the Moderna COVID-19 Vaccine and Pfizer-BioNTech COVID-19 Vaccine fact sheets.

=Individuals who receive an updated mRNA COVID-19 vaccine may experience similar side effects as those reported by individuals who previously received mRNA COVID-19 vaccines and as described in the respective prescribing information or fact sheets. The updated vaccines are expected to provide protection against COVID-19 caused by the currently circulating variants. Barring the emergence of a markedly more infectious variant of SARS-CoV-2, the FDA anticipates that the composition of COVID-19 vaccines will need to be assessed annually, as occurs for seasonal influenza vaccines.

For today’s approvals and authorizations of the mRNA COVID-19 vaccines, the FDA assessed manufacturing and nonclinical data to support the change to include the 2024-2025 formula in the mRNA COVID-19 vaccines. The updated mRNA vaccines are manufactured using a similar process as previous formulas of these vaccines. The mRNA COVID-19 vaccines have been administered to hundreds of millions of people in the U.S., and the benefits of these vaccines continue to outweigh their risks.

On an ongoing basis, the FDA will review any additional COVID-19 vaccine applications submitted to the agency and take appropriate regulatory action.

The approval of Comirnaty (COVID-19 Vaccine, mRNA) (2024-2025 Formula) was granted to BioNTech Manufacturing GmbH. The EUA amendment for the Pfizer-BioNTech COVID-19 Vaccine (2024-2025 Formula) was issued to Pfizer Inc.

The approval of Spikevax (COVID-19 Vaccine, mRNA) (2024-2025 Formula) was granted to ModernaTX Inc. and the EUA amendment for the Moderna COVID-19 Vaccine (2024-2025 Formula) was issued to ModernaTX Inc.