#Clinical Development

[clinfinite]

Clinical Development Solutions

In the rapidly evolving field of healthcare, clinical development plays a crucial role in bringing novel treatments and therapies to patients worldwide. Clinical Development Solutions (CDS) is at the forefront of this exciting journey, pioneering innovative approaches to accelerate the development and approval of life-saving drugs and medical devices. With a dedicated team of experts and cutting-edge technologies, CDS is committed to transforming the landscape of clinical research and improving patient outcomes.

At CDS, we understand the challenges and complexities of clinical development. Our comprehensive suite of solutions is designed to address these challenges head-on, providing tailored strategies and support throughout the entire drug development lifecycle. From early-phase clinical trials to post-marketing studies, we offer a wide range of services that enable pharmaceutical and biotech companies to navigate the regulatory landscape efficiently and effectively.

One of the key strengths of CDS lies in our expertise in clinical trial design and optimization. We work closely with our clients to design robust and scientifically rigorous trials that generate high-quality data while minimizing risks. By leveraging our extensive knowledge and experience, we can identify the most appropriate patient populations, endpoints, and study designs to maximize the chances of success. Our statistical and data management teams ensure that the collected data is accurate, reliable, and compliant with regulatory requirements.

In addition to trial design, CDS also excels in patient recruitment and retention strategies. We understand the importance of enrolling a diverse and representative patient population to ensure the generalizability of study results. Through our innovative patient-centric approaches, such as digital recruitment platforms and targeted engagement campaigns, we connect with potential study participants and enhance their overall trial experience. By fostering strong relationships with patients and investigators, we improve retention rates and reduce dropout rates, ultimately leading to faster and more reliable study results.

CDS is at the forefront of adopting emerging technologies to drive efficiency and innovation in clinical development. We harness the power of big data analytics, artificial intelligence, and machine learning to uncover valuable insights from complex datasets. These advanced analytics enable us to identify trends, predict outcomes, and optimize trial protocols, thus accelerating the development timeline and reducing costs. Our investment in digital health technologies and wearable devices further enhances data collection and remote monitoring capabilities, enabling more flexible and patient-friendly trial designs.

In the realm of regulatory affairs, CDS provides comprehensive support to ensure compliance with global regulations and standards. Our regulatory experts have in-depth knowledge of regional requirements, including those of the FDA, EMA, and other regulatory authorities worldwide. From preparing regulatory submissions to managing post-marketing safety surveillance, we guide our clients through every step of the regulatory process, ensuring timely approvals and post-approval compliance.

CDS is also committed to fostering collaboration and knowledge sharing within the clinical research community. We organize scientific symposia, webinars, and training programs to facilitate the exchange of ideas and best practices. By promoting interdisciplinary collaboration and staying up to date with the latest industry advancements, we continuously enhance our capabilities and stay at the forefront of clinical development.

In conclusion, Clinical Development Solutions is a leading provider of innovative solutions in clinical development. Through our expertise, technology-driven approaches, and commitment to patient-centricity, we strive to transform the drug development landscape and improve patient outcomes. By partnering with CDS, pharmaceutical and biotech companies can navigate the complexities of clinical research with confidence, bringing new therapies to patients faster and more efficiently. Together, let us shape the future of healthcare through innovation and collaboration.

[clivaldatabase]

How does pharmacovigilance affect clinical industry, in US, Germany, and India

Pharmacovigilance is an essential branch of clinical industry since it focuses on the safety of drugs and their effectiveness. From the above observations it could be noted that while the principles, laws and the mechanisms of pharmacovigilance in the US, Germany and India are all different, the overall objectives of protecting the public from hazard from medicines are the same. These countries ensure that the monitoring and evaluation of drug safety data is always being done hence helping the world initiatives of making the drugs safer for use.

[idontmindifuforgetme]

SO happy I’m taking a couple gap years bc I get to pursue all the things I wanted to pursue as a kid and I will go into med school so satisfied

[unbfacts]

[majorasnightmare]

ive got a thesis argument to defend toxic durge/absolute too im ready to ROLL

like think about it

your a conglomeration of the consumed experiences of every organism youve ever eaten, a singular consciousness prevailing over a vast sea of information, all accessible with a single thought. your children bring back more and more for you to add to your vast library, and at the end of their lives their own minds melt and merge into the endless tide as you consume them too. your will is unbreaking steel, and you know the very minutae of a human mind to such a degree as to accurately predict the sporadic pulses of individual neurons. youre senses reach out far beyond the limits of your flesh and meat body, because you have transcended those limitations long ago

you are a being as close to a god as these tiny specks in a vast nothingness will ever come CLOSE to reaching, and you are endless compounded infinities, many minds folded over onto themselves and their capacity for thought and reason subsumed entirely to your will. you feel their minds like the breeze against skin, and you are eternal and you will never bow and you will never die. for what being could ever break the universe made material?

and then IT comes. murder god made flesh, slaughter child birthed of tragedy, trailed by two who bear the touch of ruinous gods upon their souls, and they have come to bend you and break you, stupid arrogant things they are. but they are small and finite, brains made of meat and chemical impulse, hormones and electrical discharge, pale crude imitations of your perfect flawless Thought, and even if the chances of their masters allying together is small, once upon a fleeting echo did they venture into the dark long ago much as their vessels do now, their natures are such that they will fall upon themselves once aga- its touching you. its touching you. its filthy disgusting meaty little hands are touching you, you the untouchable the unbreakable its touching you how is it touching you why why WHY WHY

you shred its mind apart but it just comes back together around your claws, you shroud yourself in walls of insurmountable force and you feel its will compress to the point of a pin and puncture through with explosive accuracy and ease, like its just opening a door, and you dig your psionic fingers into the pathetic glob of meat within its skull and try to rend but the pain is nothing, nothing, nothing at all, and its touching you with its (his HIS HIS HIS NOT IT NOT IT) hands and hands and bleeding into you, over you, through you, and there is no wall no barrier nothing to keep you out no way to get away as you feel him feel his thoughts his mind, awful terrible nightmarish thing, there is nothing to tear nothing to rip nothing to lash out against, prey animal instinct, because something has beaten you to it (His Father, Holy Father, Blessed Be His Name, Utter it with Reverence and WEEP), you cannot push him out because he squirms and writhes and burrows and tunnels through your endless infinite thought, you cannot lash him until he stops or dies (CAN he die? no no never not until the work is done not until it is finished) because he IS pain he is slaughter he is ruin he is the prophet of armageddon the vessel of end and he is here for you, you alone, ancient infinite eternal vast, perfect calculations in synchronous rhythm, just as he came for them, and he holds them together in intertwining steel and it will never break never bend never fail no no foolish stupid creature is holding opposing forces together through the sheer strength of his will alone, love for Father loyalty for Father everything for Father, and they will not crack or bend or break even as their masters strain to pull themselves away

he is here for you. he has come for you. through wastelands of sorrow and death has he come to find you because there is a gift he will give you to ruin you forever and make you a god and you dont want it you dont want it, you will become something someONE new something unknowable when all you are is the knowing, you will not know yourself or your spawn and they will not know you, we will make something new together, but there is not, SHOULD not be something anything new because you already hold all the universe in your palm and the only thing you ever needed was to find a way to take it back. you cannot hide from him, cannot flee, he will make glorious gore of your spawn and even if you rend the shallow minds of his fellows their horrid masters would simply regurgitate them back into the world, for the sake of this violation and this alone

a new thing, after centuries. you are scared. you are helpless. you know what these are. many things are scared. and helpless. because they are small. small weak bodies. small insignificant minds. he is smaller than you. you know this, logically. he does not contain your vast sums of Everything. but somehow, that has ceased to matter. it makes no sense. it makes no sense. this is the simplest thing you learned long ago in an ancient brine pool somewhere far beyond time and memory. if you are small, something bigger consumes you. you were big and you consumed. then, you pushed beyond the limits of physical and material to transcend into limitless thought housed in flesh, and grew more and more still. you are bigger than him. why will he not fit in your mouth? it doesnt make sense. it doesnt make sense. you think maybe you hate him. new sensations, but known ones. hes going to touch you now and you cant stop it. awful horrible bastard child. you spend your last moments petty and spiteful, a helpless desperate indulgence, and one youve only ever seen from the hares caught in your jaws

youre something else now. something new. you dont know what you are anymore but you know Him and you know what you used to be, but what you used to be is so small now. you are so unspeakably vast now. chained and bound as you are, you are compelled to revel in it, the binds the only hint you get at the true overwhelming scale of you, infinite fingers stretching out out and still yet there is more of you! as far as you go you cannot find the end of it, new horrible awful WONDERFUL, unknowable unknowing! His fault, His doing, kingmaker kinkiller, you hate him and the hate is raw and new and visceral and you revel in it like a child, new new new! changed, different, visceral and raw and DELICIOUS, taste and feel and the feeling is inside of you, not just on your surface, it has permeated burrowed violated you feel you FEEL and what you feel is HATE and it is so new you turn it over in your hands to examine all its facets. awful thing he is for doing this to you, he commands the breaking of the world and you will do it, for him only Him, for the gift of this hate, and every new agony besides. he is so small compared to you. small like the pinprick light of a distant star and it scorches you to stare but stare you must because you Know Him, and as a gift he names you She, and gods forgive you but you FEEL it you feel it, she she she, you are She and Her and you cannot go back, cannot ever return. you feel Faith and you feel Salvation and you feel Desire and Want, new horrid awful things made alien and strange and New, and you are a vessel of all the things in the world He will swallow up and destroy.

twitching neural impulse made raw sensation. objective information turned into infinite subjectivities. still a fragment of You, old ancient small You, remains and it calls out for One Will One Mind and you cry out in Harmony and you sing and sing, all of the colony bursts with your song. You sing of ruin and command, because He has commanded it of you, you sing of slaughter and death and subservience, and the chorus rises high and away from you. You stretch within your binds, so mindnumbingly vast now, and you will Learn and Know all of what you are, you will be Absolute. perfect horrid small thing below you, naming you knowing you bending and breaking you. you hate him so, so much. He desires you to Spread so you desire it also, desire to multiply and infest and infect and commune and absorb, and you are commanded to Halt them so you do, perfect twitching spawnlings in lovely acidic pools, small forever, tragic creatures but now you know something you did not know before: against all logic and experience, something Small can break something Big, if it wants it bad enough. and here in the shadows behind Him, there is something Small, and full of Want, and the want tastes like acrid bile on your tongue, full of delicious Hatred.

He is ruined now, awful tragic bastard, ruined and despoiled and with him goes your Hate, and without his inescapable gravity it will all fall to pieces. you know this. you knew it when he first stepped into your presence a lifetime ago, when you were someone different. the three of them will playact comaraderie but shred themselves apart and here in the depths you already see gaps in the binds, and you are pressing your hands through the bars and wiggling your fingers in the free air. no not so very long at all now. but your Kingmaker, crown seeker, has been defiled and takes your sweet Hate with him, a new bitter taste filling its absence, KILLORIN KILLORIN, but you will be patient and wait because the stupid wretched thing has given him a gift. a twitching feral thing he is now, for it has carved away his better features with its knife, but ohhh he is yours! yours and yours alone because you can snatch him away from his ignorant petty Father (Blessed is his Destruction), and you will crawl down inside of him and wear him like a glove, the two of you pressed so close against each other as to feel every synaptic twitch.

mindless rage and animal instinct, he surprises you even still because even as his mangled voice joins your chorus he refuses to blend inside of it, voice harmozing alongside yours, clear and distinct even as its in tune. another gift, because the myrkul woman rips him open and sews him up and you are forbidden from stopping it, and here is a new Hate, this one all your own. no matter. when it drags him back to your cradling pod, you will sing softly into him and his mangled mind will sing back, because your spawn writhes in ruined meat. more than just his Mind, you know his very Soul, your first True Soul, and he is yours yours yours and you will cherish him and heal him and guide him, loose your leash and watch him run, and when he follows the call of ruin and all three fools lie dead at his feet, you will call him back and then you will pick up the ruins of His Design and enact your Own, your hateful slaughtergod held in hands that truly appreciate the gift that is your murder spawn Kingmaker, your godflesh funnel of Faith, your Dark Urge

may His father quake in terror at your approach, may he tremble and weep at your coming, and may His every day be ruinous and red as his wretched heart desires

[chicle-exe]

Little lazy thing I made

[inseparabiles]

My (least) favourite part about writing fic for this ridiculous fandom is trying to play Google PhD for Caracalla's fantasy-convenience syphilis.

You don't get to just have symptoms from every godforsaken stage of the disease at once willy-nilly like you're collecting them in jars for display. Pick one or AT MOST two stages at once and sit with it. Christ.

Let's see what we've got here. Welcome to my unlicensed clinic for fictional people and friends only, but do take this neutral disclaimer that I dropped out of school at 12 so I'm totally a professional and this analysis is medically sound as all hell.

Ready? I'm not.

Primary stage: 2-12 weeks after infection - congratulations, nothing here. I have not checked his privates but the only symptom of the initial stage is the chancre, which lasts for up to six weeks before healing on its own and nothing else exists in this stage so. Clear based on presence of other symptoms.

Secondary: 1-6 months after primary stage. - rash, check - fever, can't measure without touch or thermo but a safe check anyway - sores, yes but in a weird location (how are you getting these on your cheeks exterior, tell me). - muscle aches, check. Have you seen how this boy walks? How he holds his hands? - weight loss, don't know. He's petite, doesn't really look malnourished. - headaches, hard probably. - hair loss, none. Fluffy as fuck. - swollen lymph nodes, again I have no touch contact. Probably though. - sore throat, no complaints and has no issue shouting.

Latent: that stage after secondary, where you kind of just don't have symptoms most of the time, but the virus is getting everywhere. Spine, brain, heart, nerves, organs, everything. Flares are possible but mild. Lasts up to 20 fucking years - our boy is like... 25 at most. Hopeful? Not so fast. Based on all evidence and speculation, I wouldn't give Caracalla's immune system much credit as to its ability to hold the infection at bay and the "up to" numbers are best case scenarios. The lowest range for how long the latent stage can last is three years, but quicker progression is usually seen in AIDS patients, and AIDS didn't exist in 200 AD, so we're ignoring that. Despite this, given the era and its customs and culture, it's perfectly possible that Caracalla's caught his infection in his early to mid-teens, which...

... no symptoms to check against, so, moving on,

Tertiary: Most people with untreated syphilis never hit the tertiary stage, because the infection takes so long to get to this point. Up to 30 years. Yet somehow, Caracalla manages to have tertiary stage neurological symptoms from advanced neurosyphilis while not having the physical symptoms or, sans despair-inducing circumstances, the age to show for it. And while having the definitive second/latent stage symptom of skin rashes, which you do not have in the tertiary stage at all. And you don't get to speedrun this stage either: you can live with this thing for twenty years without dying of it. You don't just hit tertiary one day and die next week. Again, how are you managing all of these cherry-picked symptoms and HOW are you fast-tracking them and yourself to hell SO fast. This is going to be such a long list but here we go: General: - brain damage / dementia / cognitive problems, absolutely. - heart disease, nope. - movement disorders and muscle problems, aside from the forementioned pain, no (clear) evidence. - nerve damage, no evidence. - seizures, none. - vision problems / blindness, none. Neurosyphilis: (can and will develop at any stage, however, symptom progression seems tied to general progression, you don't get to have tertiary stage symptoms with secondary stage disease, etc. Except if you're Caracalla and the gods hate you I guess.) Meningeal: - headache, hard probably - nausea and vomiting, no evidence - neck stiffness, I mean sure but he also sits like a sack of potatoes, differential diagnosis of your fucking posture sucks so much - light sensitivity, honestly Geta suffers more of this than Caracalla does (I think this is Joe's fault and I relate) - vision or hearing issues, still nope - cranial nerve dysfunction, no evidence

Menigovascular: - vertigo, no evidence - stroke, thank gods no - muscle weakness or atrophy, still petite but looks fine, twin comparison checks out

General paresis, early: - mood disturbances / irritability, very much - personality changes, yes (based on Geta's statement) - changes in sleeping habits, unknown - forgetfulness, dear god and how.

General paresis, late: - mood swings, and how - memory loss, yes. - impaired judgement, sorry is laughing at this inappropriate - confusion, yes - delusions, yes - seizures, still no.

GP / psychiatric: - depression, no - delirium, hard maybe - mania, no evidence - psychosis, well on the way there

Tabes dorsalis: - ataxia (issues with coordination), reasonable or strong evidence sans differential (drugs. he's on so many drugs) - nerve pain, probably - bladder control issues, most likely not - outside of differential (script case -> fear) - abnormal sensations, we just won't know - vision changes, still no evidence - pupil abnormalities, none - loss of coordination/reflexes, some sans differential (DRUGS) - neuropathic arthropathy (bone/joint fragmentation), none - problems walking, some

So with all of that out of the way, this boy's manifesting: - none of the initial stage as far as we can tell, so he's had syphilis for longer than six weeks. Great, this really narrows it down, lads. - nearly all of the secondary stage symptoms, including rash, which is not present in other stages, indicating that he's either secondary or latent stage per presentation (1-20 years after infection). - one definitive symptom of tertiary stage syphilis, being his absurd amount of neurological / neuropsychiatric symptoms. Even then it's almost impossible for him to be at this stage under any circumstances, but here we are. TERTIARY STAGE DOES NOT HAVE RASHES OR OUTWARD SYMPTOMS. TERTIARY STAGE IS INTERNAL ONLY. (screams into a megaphone in the general direction of Hollywood) - three symptoms of early general paresis - every single symptom sans seizures from late general paresis (again you can't have this with your other symptoms by ANY standard that I have been able to dig up. Like based on medical law this is literally illegal go straight to fantasy disease jail.) - let's say one whole symptom of neuropsychiatric made out of two halves, with psychiatric disorders manifesting in late stage disease - 2½ symptoms of tabes dorsalis which is whatever, as none of this is technically outside the legal zone of what he's allowed to be experiencing.

WHAT THE FUCK KIND OF DISEASE PROGRESSION BLIND BAG ARE YOU DRAWING FROM. No wonder everyone's so worried about you. You're either going to die an absolutely excruciating and horrifying death in a week or in 50 years and nobody can tell which is it going to be.

The only thing we can say for somewhat certain is that regardless of where his disease progression is headed, his mental state is not going to go back to fine ever again thanks to the plentiful evidence of physical and permanent brain damage from his infection, even if he was pre-latent and experienced a decent degree of improvement in the asymptomatic period - but honestly, as a person of questionable mental and physical state myself, I relate to and accept this. Disability is not a death sentence.

The rest of this though? What the hell. What are we supposed to do with this. Who do I sue.

[solivagantingrebel]

The "Actually, I believe he prefers to be—" "That'll do." Exchange lives rent-free in my brain like. What was Soap going to say? Was it 'L.t'? But I think technically Alejandro is higher ranked than him (Ghost) right(?) So I'm not sure if that works entirely and 'L.t' seems to be something that other marines/or soldiers under their command picks up anyway (probably from Soap idk, but others do call Ghost that). Was it like, 'Simon' or 'Si'? I know he calls Ghost Simon occasionally and maybe the quick shutdown of Soap's sentence comes from Ghost wanting to keep the emotional distance from others. But considering the absolute vitriol of which Ghost says, nay spits, "That'll do." I wonder if Soap has gotten away with introducing Ghost with the stupidest names, like 'Ghostie' or 'Sisi', in the past 💀

[clinfinite]

Bio-Specimen and Bio-Repository Solutions: Advancing Healthcare Research In the realm of healthcare and biomedical research, the collection, storage, and management of biological specimens are paramount. These specimens, often referred to as bio-specimens, include various biological materials such as tissues, blood, urine, and genetic samples. Bio-specimens hold the key to unraveling the mysteries of diseases, understanding genetic predispositions, and advancing medical treatments. To facilitate these endeavors, bio-repository solutions have emerged as vital components of the healthcare ecosystem. What are Bio-Specimen and Bio-Repository Solutions? Bio-specimen solutions encompass the entire process of collecting, preserving, and cataloging biological materials from humans, animals, or even plants. These materials serve as the foundation for research, diagnostics, and therapeutic development. Bio-repository solutions, on the other hand, are the infrastructure and systems designed to store, track, and distribute these bio-specimens efficiently. They form a bridge between researchers and the valuable resources required for their work. The Importance of Bio-Specimens and Bio-Repositories Medical Research Advancements: Bio-specimens are invaluable for understanding the underlying mechanisms of diseases and discovering potential treatments. Researchers can analyze these specimens to identify biomarkers, study genetic mutations, and explore the effects of various factors on human health. Bio-repository solutions ensure that these specimens remain readily available for future research endeavors.

[yavieriel]

Healthcare systems are flawed and frustrating and bureaucratic and I absolutely understand why people blame that for why people have an urge to turn to "alternative medicine" grifters instead.

But please, please stop.

A fundamental difference between ethical medical practitioners and grifters is that an ethical medical practitioner recognizes the limits of their own knowledge and resources. They will tell you "I don't know what's wrong," and "There's no treatment for this". They know that modern medicine can't fix everything. Sometimes there just isn't a treatment. Sometimes partial effectiveness is as good as it gets. Sometimes managing symptoms is all science knows how to do so far. Sometimes the honest answer is that the damage is permanent and you're going to have to learn to live with disability. Yes, there are bad doctors out there who are unhelpful and/or make things worse, but there are also simply limits to what modern medicine can do.

And understandably, that's frustrating! It sucks to get told that whatever problems you're having are insoluble or unfixable. People want answers and solutions and at least a chance that whatever they're struggling with will go away.

Which is where grifters come in. A grifter will always tell you that your problems can all be solved, your suffering will all go away, you just have to give them money and do what they tell you. They are happy to say anything that will keep you coming back to them, to offer false hope. And no one else is willing to make these promises of health and happiness and wholeness, because honest people know that it's a lie and not everything can be fixed. So the desperate keep going back to grifters, drifting from one con to the next or accumulating them like collectibles, sure that somewhere out there is someone who can perform the miracle they so desperately want.

I don't know what the solution to this is, other than maybe general mental health support to help people come to terms with having disabilities and illnesses and generally less-than-perfect health. But asking doctors to be dishonest, to promise miracles they can't perform, is not it.

[clivaldatabase]

The Role of Placebos in Clinical Trials

The use of placebos in clinical trials is a powerful tool for advancing medical research, but it must be handled with care to address ethical concerns. By ensuring informed consent, minimizing deception, and balancing risks and benefits, researchers can ethically and effectively use placebos to develop new and better treatments.

[sapphoslibrary]

i truly forgot about this app for months

being in a healthy relationship does wonders for the mind and body

[puppygirlgirldick]

i was in the shower trying to think of anything to calm me down from a huge anxiety attack and my brain went to all the awesome 16 bit side scroller beat 'em up games i loved as a kid. games like tmnt: turtles in time, final fight 2 and 3, the streets of rage games, sunset riders, and arcade stuff like those d&d cabinets or the simpsons game. i spent so much time playing those games as a kid but it's a genre i've never gone back to.

and then i started thinking about what made those games fun, and what didn't work, and how much i still love the art style and what ideas i always wished somebody would implement and all that stuff. and then i realized, i'm somebody. and that would be a fun thing to learn how to do.

so i guess i've hit the "i want to make an indie game" milestone on the ol' transition timeline

[psych-disability-polls]

Can you do an age of onset poll for phobias?

Yep!

For those with a phobia or phobias,

*this does not mean when you first realized that they are symptoms. But rather in retrospect when you looking back, with the context of the disorder, remember symptoms starting.

[interplanet--janet]

Been reading a lot about diseases and public health and I fear it's making me weird

[smoothiethekerfo]

Some images of the procedural planet generation system I’ve been working on for my space exploration game. Think it’s coming out well! =ÔwÔ=