#clinical development

[clinfinite]

Bio-Specimen and Bio-Repository Solutions: Advancing Healthcare Research In the realm of healthcare and biomedical research, the collection, storage, and management of biological specimens are paramount. These specimens, often referred to as bio-specimens, include various biological materials such as tissues, blood, urine, and genetic samples. Bio-specimens hold the key to unraveling the mysteries of diseases, understanding genetic predispositions, and advancing medical treatments. To facilitate these endeavors, bio-repository solutions have emerged as vital components of the healthcare ecosystem. What are Bio-Specimen and Bio-Repository Solutions? Bio-specimen solutions encompass the entire process of collecting, preserving, and cataloging biological materials from humans, animals, or even plants. These materials serve as the foundation for research, diagnostics, and therapeutic development. Bio-repository solutions, on the other hand, are the infrastructure and systems designed to store, track, and distribute these bio-specimens efficiently. They form a bridge between researchers and the valuable resources required for their work. The Importance of Bio-Specimens and Bio-Repositories Medical Research Advancements: Bio-specimens are invaluable for understanding the underlying mechanisms of diseases and discovering potential treatments. Researchers can analyze these specimens to identify biomarkers, study genetic mutations, and explore the effects of various factors on human health. Bio-repository solutions ensure that these specimens remain readily available for future research endeavors.

[solivagantingrebel]

The "Actually, I believe he prefers to be—" "That'll do." Exchange lives rent-free in my brain like. What was Soap going to say? Was it 'L.t'? But I think technically Alejandro is higher ranked than him (Ghost) right(?) So I'm not sure if that works entirely and 'L.t' seems to be something that other marines/or soldiers under their command picks up anyway (probably from Soap idk, but others do call Ghost that). Was it like, 'Simon' or 'Si'? I know he calls Ghost Simon occasionally and maybe the quick shutdown of Soap's sentence comes from Ghost wanting to keep the emotional distance from others. But considering the absolute vitriol of which Ghost says, nay spits, "That'll do." I wonder if Soap has gotten away with introducing Ghost with the stupidest names, like 'Ghostie' or 'Sisi', in the past 💀

[lesbianaelwen]

I was wondering who kipperlily was reminding me of, and I finally remembered last night—ocean from ride the cyclone. as in, yes, these morals are fucked but also this is a child. it is the moral duty of the adults around her to foster better morals and traits like compassion and empathy. I can’t blame her for being so primed to be taken advantage of; that being said, if/when that influence is removed and if she is given a chance to change, that is on her.

in a meta sense, brennan has established that there is a difference in the teenage villains he creates, and the vast majority of them are not pure irredeemable evil—they were influenced/groomed into their role and given external support/the ability to be free from that and change, they take it. how I’m seeing it, that’s being set up for at least a few of the rat grinders.

[the-rest-of-what-remains]

Copperrush and Peridotpath, can you tell us a bit about your family?

[willowcrowned]

the thing about the life series is that it’s literally not that deep. but it will make you insane

[stuckinapril]

I am so glad that I’m setting aside time to volunteer.

[leverage-ot3]

me at my physical rn

med assistant: would you like to have your weight updated today? you don’t have to if you don’t want to

me: *don’t do it don’t do it don’t do it it won’t match the scale at home it will make you feel shitty it will flare up your ED even more for the rest of the week and you already did it today in anticipation of the physical* yeah sure why not

it was 7 pounds different than my scale at home goodbye self esteem it was nice knowing you 🫡

[theredwallrecorder]

outcast: the necessity of the mace

The kestrel spoke around a beakful of chestnut: “I am Skarlath; I was alone, but you saved my life; now I am with you. Where come you from, friend?”

Scratching his golden stripe, the badger chewed thoughtfully. “I’m not sure. I think I had a mother, Bella or Bellen or something, it’s hard to remember. I must have been very young. Boar the Fighter, that’s a name I recall, maybe he was my father, or my grandsire, I’m not certain. Sometimes I dream about home, or maybe it’s my imagination, but it feels nice. Then there’s the mountain, was that my home? It is all very mixed up.”

Sunflash speaks about himself, excerpt from Chapter 2 of Outcast of Redwall

one of the reasons outcast differs from every other novel of redwall is in the fact veil, the titular character, does not even exist until the eighteenth chapter of the book. the previous seventeen chapters are spent building the rivalry between swartt sixclaw, the primary antagonist, and sunflash the mace, ascendant badger lord. though he may not have done so intentionally, mister jacques’ inclusion of the experience of sunflash allows us to draw comparable narrative lines with veil’s story. sunflash is fortunate to bear memories of his early childhood that become the lynchpin for his growth into a just, kind, and wise badger lord and friend. this foundational aspect of backstory, echoed more explicitly in the narrative of deyna in taggerung and rooted in current theories of psychology and human development, postulates that positive experiences with a parental guardian in early life are necessary for healthy growth and formation of the self. in future posts, we will weigh the differences between sunflash’s early childhood and veil’s early childhood; here, we will extrapolate what sunflash’s early memories imply about his childhood environment.

though his memories are certainly sparse, the tone and descriptive words sunflash uses to talk about his early childhood betray more about it than he is consciously aware of. he begins his reminisce with his mother: she is the largest figure in his memory as a baby. her name comes to his lips immediately, though when he presses against the fog of memories, he falters in his confidence. so much of the secure base of his babyhood has been eroded by the cruelty he experienced at the hands of swartt. bella likely spoke to sunflash of boar the fighter even before he could understand speech, sharing the legacy of their bloodline and imparting some of the sense of the destiny of badger lords to her son--whom she knew, even as he was a babe, he would one day take on that heavy mantle. perhaps boar even visited little sunflash in his early dreams, as is the mysterious power of some badger lords, which could explain sunflash’s vague sense of the existence of salamandastron. it is one of the latter lines of sunflash’s dialogue that gives us the most information about his formative environment. he dreams of his home and the emotions those dreams conjure for him are inherently positive. these dreams bring him comfort and they are totally unlike his reality at the mercy of swartt. “... it [thematic elements of home] feels nice.” what does “nice” mean for a baby? we can easily guess. there was safety. there was security. there was warmth. baby sunflash’s basic needs were met: he did not go hungry, somebeast tended to him when he cried, and he was groomed and cared for.

swartt tried his absolute damndest to beat any sense of personhood out of sunflash. swartt gave sunflash a degrading name, forced the young badger to commit acts lower than a slave, deprived sunflash of food and drink, and left him exposed to suffer the full effects of the weather. swartt did not succeed in breaking him because sunflash carried his verifiable sense of self borne out of the scant memories of his childhood. sunflash knew he had a benevolent mother figure. he knew he had a family history, the promise of having come from somewhere and something of any measure of meaning. he knows he had a home: a place where he was wanted, where he belonged. it was a place where he was safe, where his needs were met, and where his worth as a living creature was imparted. sunflash subconsciously knew that swartt could not truly define him.

veil, in strikingly direct contrast, was given none of these things.

[cbirt]

Researchers from Insilico Medicine designed and devised inClinico to predict Phase-II clinical trial outcomes. The transformer-based artificial intelligence software platform, inClinico, conjugates an ensemble of clinical trial outcome prediction (CTOP) engines that harness generative artificial intelligence and multimodal data that consolidates omics, text, clinical trial design, and small molecule properties. Integrating multimodal data sources, multiple scoring approaches, and biological background along with deep learning models, inClinico software generates a probability of success (PoS) against a Phase II clinical trial evaluation to furnish insight into the probability of Phase II success and, thereby, the transition from Phase II to Phase III. The inClinico CTOP models can be leveraged by the pharmaceutical industries to optimize funding and elevate productivity.

The success of Drug discovery and development is a blessing for civilization, but the expense and involvement of risk in terms of labor, finance, and time; that are associated with the entire process from the pre-discovery stage to marketing are enormous. Computer-aided techniques now ubiquitously complement the pre-discovery and discovery stages.

After that, the clinical trial phase alone takes 6-7 years. Generally, several thousand volunteers are clinically tested with the drug in Phase II. A prior notion about the likelihood of success in the clinical trial is advantageous regarding the effectiveness, the productivity of the R&D department of a pharma company and provides beneficial estimation in cutting down on irrelevant expenses due to failure and further financial investments.

Several attempts have been made to develop artificial intelligence technologies that will foretell whether the clinical trial will be successful. Such works included toxicity prediction through machine learning scoring ensemble based on drug descriptors and target features, drug-induced pathway activation and consequent side effects of a drug, a deep neural network to predict clinical trial outcomes using multimodal data on the molecule tested, etc.

Continue Reading

[clinfinite]

Bio-Specimen and Bio-Repository Solutions

Bio-Specimen and Bio-Repository Solutions: Advancing Healthcare Research

In the realm of healthcare and biomedical research, the collection, storage, and management of biological specimens are paramount. These specimens, often referred to as bio-specimens, include various biological materials such as tissues, blood, urine, and genetic samples. Bio-specimens hold the key to unraveling the mysteries of diseases, understanding genetic predispositions, and advancing medical treatments. To facilitate these endeavors, bio-repository solutions have emerged as vital components of the healthcare ecosystem.

What are Bio-Specimen and Bio-Repository Solutions?

Bio-specimen solutions encompass the entire process of collecting, preserving, and cataloging biological materials from humans, animals, or even plants. These materials serve as the foundation for research, diagnostics, and therapeutic development. Bio-repository solutions, on the other hand, are the infrastructure and systems designed to store, track, and distribute these bio-specimens efficiently. They form a bridge between researchers and the valuable resources required for their work.

The Importance of Bio-Specimens and Bio-Repositories

Medical Research Advancements: Bio-specimens are invaluable for understanding the underlying mechanisms of diseases and discovering potential treatments. Researchers can analyze these specimens to identify biomarkers, study genetic mutations, and explore the effects of various factors on human health. Bio-repository solutions ensure that these specimens remain readily available for future research endeavors.

Personalized Medicine: In the era of personalized medicine, bio-specimens play a pivotal role. By studying an individual's genetic profile or specific biomarkers, healthcare providers can tailor treatments and therapies to maximize effectiveness while minimizing side effects. Bio-repositories help maintain a diverse collection of specimens, facilitating these advancements in healthcare.

Quality Control and Assurance: Proper storage and handling of bio-specimens are essential to maintain their integrity and reliability. Bio-repository solutions incorporate state-of-the-art technology and strict protocols to ensure the quality of stored specimens. This, in turn, enhances the reproducibility of research findings.

Longitudinal Studies: Some research projects require the analysis of bio-specimens collected over extended periods. Bio-repositories enable the storage of specimens for many years, making it possible to conduct longitudinal studies that track changes in health and disease progression.

Challenges in Bio-Specimen and Bio-Repository Management

While bio-specimen and bio-repository solutions offer immense benefits, they also come with unique challenges:

Ethical and Legal Considerations: The collection and use of bio-specimens often involve complex ethical and legal considerations, including informed consent and privacy protections. Managing these aspects requires careful attention to regulations and guidelines.

Data Management: Bio-repositories not only store physical specimens but also associated data, such as patient information and experimental results. Ensuring the security and accessibility of this data is crucial.

Sustainability: Maintaining a bio-repository is resource-intensive, and long-term sustainability can be challenging. Funding, infrastructure, and skilled personnel are essential for its continued operation.

Standardization: To enable collaboration and data sharing among researchers, standardization of processes and data formats is essential. Harmonizing practices across bio-repositories can enhance the utility of collected specimens.

Future Directions in Bio-Specimen and Bio-Repository Solutions

As technology advances and research methodologies evolve, bio-specimen and bio-repository solutions will continue to evolve as well. Some key trends and future directions include:

Digitalization: Embracing digital technologies for cataloging and managing bio-specimens and associated data will enhance accessibility and collaboration among researchers.

Automation and Robotics: Automation in bio-repositories can improve efficiency, reduce human errors, and increase the capacity for specimen storage and retrieval.

Integration with Omics Technologies: Linking bio-specimens with omics technologies (e.g., genomics, proteomics) will enable more comprehensive and detailed analyses, opening new avenues for research and diagnostics.

Global Collaboration: Bio-repositories will increasingly collaborate on a global scale, allowing researchers to access a broader and more diverse range of specimens for their studies.

In conclusion, bio-specimen and bio-repository solutions are indispensable in advancing healthcare research and improving patient outcomes. As these solutions continue to evolve and address challenges, they will remain pivotal in unlocking the secrets of diseases, facilitating the development of personalized medicine, and driving innovations in the field of healthcare. Researchers, healthcare providers, and society as a whole stand to benefit from the continued advancement of bio-specimen and bio-repository solutions.

[the-casbah-way]

i finally got up. it only took me until 5pm but i did it. now what

[goatmilksoda]

They should pay me to hang around my town's community college and get every degree they offer. I bet I could. They should let me try. Cowards.

[whump-captain]

- Day 21 -

Prompt: “Please”

---

@crash-bump-bring-the-whump​ i believe u said u wanted to see Ethan begging? here he is begging (◡‿◡)

this is probably longer than it needs to be but i had lots of fun writing the dialogue for once lol

---

CN: restraints, broken bone (pre-established), interrogation, strangling, torture, cutting, scalpels, hair grabbing, tape gag, bag over head

---

Ethan gasped when the bag was ripped off of his head. The light, though dim, was enough to make him wince after what felt like hours in the dark. He blinked quickly, trying to force the world back into focus.

The first thing he felt clearly was a grip of rope around his arms. His stomach sank. He lurched forward and the chair scraped on the bare floor. Pain shot through his arm, dispelling the haze completely. On instinct, he raised his right hand to shield himself and froze in surprise when he succeeded.

He was only tied to the back of the chair, not the armrests. The rope went around one of his biceps, then behind his back, and then around the other. It wrenched his shoulders back uncomfortably but still, a wave of nauseating relief washed over him. They didn’t tie down his broken arm.

A shadow fell on him and drew his gaze up. Ethan shuddered when Linde gave him a tight-lipped, professional smile.

“Good morning, Ethan,” Linde said. His voice was smooth and amiable but in his eyes was a glint of something cold and dangerous, like frostbite creeping through dying tissue. Circling the chair, he nodded his head towards Ethan’s arm. “I’ve done you a favour, as you can see. I’m hoping we can have a constructive conversation.”

Anger lit up in Ethan’s chest and made his face flush. How dare this man say that to him? After barely letting him speak the last time, after causing him so much pain?

“Me, too,” he hissed.

“Constructive and honest,” Linde added. “Lying only wastes both of our time.”

“Yeah.” Ethan’s voice shook like the rest of him. But behind the cracked lenses of his glasses, his gaze was hard. “But you’re the one who’s lying.”

Linde stopped his pacing. “Excuse me?”

“You don’t really believe I’m a spy. If you did, you’d turn me over to someone, or you’d- you’d kill me.” Ethan barely managed to get those words out. “It doesn’t make sense.”

Linde regarded him, his face unreadable. Ethan fought to keep his breathing even, hating how clear it was that he was afraid. He set his jaw tight and met the other man’s eye defiantly.

Finally, Linde turned. He tapped his fingers together behind his back, falling back into his slow prowl. 

“You’re perceptive,” he said. His small smile almost looked satisfied. “No, I don’t believe you’re a threat. If I did, you’re right, I would eliminate you.” He took a step forward and Ethan flinched. “But I see through you. You think that you’re above the consequences of what you do. You’re arrogant.”

“What?”

“You really thought you could infiltrate one of the most secure places in North America. You thought you could just… Walk in. And lie your way out of it.” Linde sounded almost offended. He lifted his chin slightly. “It’s about the principle of things. If I allowed something this brazen to go unaddressed, what kind of officer would that make me? Hm? If I didn’t find out the truth before turning you in?”

He leaned in close and all air seemed to leave the room. His shadow on Ethan’s face blacked out reality and pulled Ethan back through time, into the memory of agony.

“You’re wrong,” he managed through gritted teeth. “I didn’t infiltrate anything, you brought me here!” His voice rose and then cracked as his throat constricted. “You’re the one who’s arrogant because you refuse to listen to anything I say! I told you the truth, you’re just too stubborn to realise it.”

“Brazen,” Linde repeated. He seemed to savour the word. “I told you, I can see right through you. No matter how well you lie.”

He drifted to the other side of the room, where shadows outlined the shape of a table. Even though the distance between them grew, Ethan’s heart beat even faster now.

“Why do you need me to say anything, then?” he asked. He dug his fingers into the armrest to hide their trembling. “You made up your mind, you’re happy with your story, just turn me in, then. Let me talk to someone above you.”

“Like I said.” Linde ran his hand along the table’s surface and something clinked. “Principle. I don’t just want the truth. I want it from you.” 

The sudden force of his stare made Ethan recoil. Something cold crystallised in the air between them. He recognized the cold in Linde’s eyes and it made a hollow pit open in his stomach.

“Let’s start simple,” the captain said, taking a leisurely step forward. His hands were behind his back again. “How did you get to this island, Ethan?”

“On a boat.” Even the short sentence made Ethan’s breath come heavy. “It’s on the eastern shore, you can check.”

“Good. Now, how did you know where to find this island?”

“I- I followed a radar.” No matter how hard he tried, he couldn’t keep his breathing even. “There was an anomaly registered by a weather station on the mainland and- I followed that. It didn’t lead to the island but the- the area around it. I- I didn’t know it was here. I almost crashed.”

Linde lowered his head and gave a quiet sigh. ”Weather station,” he repeated, almost amused.

“Yes! You can call them, they’ll tell you what time I left, which boat I took out, it’s all on the record.”

“You’re very thorough.”

“And you’re not!” The chair scraped forward with the force of Ethan’s shout. “Because you refuse to do the bare minimum to verify your claims and find-”

Linde seized his throat. The impact strangled Ethan’s words and pushed his head backwards.

“I was honest with you,” Linde said quietly. “Civil. And in return, you don’t just lie to me, you start insulting me.” His grip tightened. “I thought you were a smart man, Ethan, don’t make me change my mind.” 

Ethan couldn’t struggle. The rope held him fast, Linde’s fingers dug into his skin. With every torturous second, his lungs compressed, fighting, until it felt like they were on fire. His mouth moved soundlessly around smothered cries. Burning white danced in his vision, blurring everything into a cacophony of melting colours. A horrible buzz filled his ears - his own rushing blood. He barely heard Linde’s words:

“Let’s move on.”

Ethan strained pointlessly, he couldn’t reach the hand choking him. His fingers clawed at the air. He couldn’t move, he couldn’t run, he couldn’t breathe. 

Linde spoke loud and his voice ripped through the static in Ethan’s head: “You think I’m wasting time, let’s cut straight to the chase. Who sent you here? And choose your answer very carefully because, believe me.” He leaned in closer and squeezed Ethan’s throat, fingers like iron bars. “My patience is running thin.”

Then he released him. Ethan choked on a gasp and immediately convulsed in a coughing fit. Air forced itself back into his body and every breath made his chest feel like it would burst. He couldn’t stop his voice escaping, he wheezed and groaned with every involuntary, fitful exhale. Linde stood motionless, watching him. Waiting. 

“I wasn’t- sent here,” Ethan choked out finally. His throat burned, the pain of the forming bruises enclosed his windpipe and made every word hurt. “I’m not here for- whatever this place is. It’s the truth.” It wasn’t a shout anymore, but a plea. He fought for breath, fought to stay afloat in his own battered body. 

Footsteps made him look up. Linde’s silhouette doubled and swayed before him, turning back towards the table. When he came into focus, he was holding a scalpel.

 “Wait.” Ethan’s voice cracked. “You- you don’t have to-” he stammered. “Please, I don’t know what you want me to say.”

Linde grabbed a fistful of his hair and wrenched his head sideways. “I thought it was simple.” He brought the scalpel close to Ethan’s neck. “I want you to tell me who sent you.”

“I was- I’m- I-” The metal reflected in Ethan’s wide eyes. He was shaking so much his glasses slipped down his nose. “The- Th- The CIA! Fine? The CIA sent me, you don’t have to- Please, don’t do this, I’m-”

“Now you’re just making things up,” Linde said.

He sliced down, across Ethan’s clavicle. The blade parted fabric, skin, and muscle like paper. Ethan screamed, his body twisting with tension. Linde pulled his head back by the hair and cut open his shirt, exposing the deep wound. 

“That’s the first,” he said. He sank the scalpel into Ethan’s shoulder and dragged it slowly down. Metal scraped against bone. Pain burned through Ethan’s mind, forced a ragged, stuttering howl out of him. His breathless groans almost drowned out Linde’s ice cold voice when he finished:

“And that’s the second lie you’ve told me.” He tilted the scalpel and more blood poured out of the widened cut. “Are you still with me?” He brought his face close to Ethan’s. “Is this a waste of time?”

“Stop,” Ethan gasped. “Please. This is all- a mistake.” His breath hitched, words fragmented into high-pitched, desperate noises of pain. Linde’s eyes shone like a snowstorm.

“I’m losing my patience.”

The next cut was diagonal, crossing over the already damaged skin. Ethan’s scream rose and then faltered, he convulsed in the restraints. The blade tilted again and ran slowly just under the skin, slicing it away from muscle - one side, then the next. Lines of living fire spilled through Ethan’s body, one after the other, emerging with each new stream of thick blood pouring out. He could only sob now, his throat raw and lungs empty. He had no time to breathe between the cuts.

“Tell me.” Linde’s voice was no more than a hiss. “Anything.”

Ethan could barely see. The pain blurred everything into a red haze.

“Please,” he whispered.

The grip on his hair tightened. The added tension made him groan as the scored skin shifted. Then it disappeared and his head lolled forward. The room spun. Footsteps mixed with the pounding of Ethan’s heart in his ears.

Something made a loud scraping noise and then Linde said: “I’ll let you think about it.”

He pressed a strip of tape over Ethan’s mouth. Ethan wheezed desperately, his breath hitching against the barrier. Another cry died in his throat and only made it out as a muffled whimper. 

Then Linde put the bag over his head again. He said: “This can come off when you’re ready for a constructive conversation.”

When the next incision came, Ethan couldn’t even brace for it.

[self-dx-culture-is]

Self dx culture is both understanding that you most likely have something or have sub-clinical symptoms that could develop into it while also going "Couldn't be me, I'm Totally Normal™"

-CCC

Literally me with psychosis

[intrinsequehealth]

Intrinseque Health - Clinical Supply Chain We Build and Execute Complex Clinical Supply Plans

Intrinseque Health is an EN ISO 13485 Certified Global clinical trial support services provider committed to the utmost in service delivery to drug development organizations (Pharmaceutical, Biotechnology, Medical Device & Contract Research Organizations (CROs)). Our team of industry professionals has over 300 years of combined experience supporting global clinical trials across a wide array of therapeutic areas. This vast experience enables us to empathize with our Customers while providing best-in-class solutions to overcome the hurdles and pain-points of conducting a clinical trial.

Regions & countries throughout the world will often present a unique set of regulatory and logistical challenges. It is our responsibility to understand and overcome these while ensuring that your products, supplies, equipment and services are available where needed to ensure study timelines are met. Intrinseque Health utilizes an operational methodology that is based on proven, cost-effective clinical supply chain strategy for each clinical trial. Our practice is to engage with our customers, early and often to ensure implementation of a robust clinical supply plan, resulting in the most successful study start-up and initiation.