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#and his many other selves
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starmocha · 16 days
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How many Dawnbreaker fics do I need to write before AO3 gives me a Dawnbreaker tag
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There was this one fan animated Zelda series on youtube I watched like 12 years ago. I think it got to either the 6th or 9th episode before going on what I presume was indefinite hiatus, and I used to rewatch the whole thing every once in a while hoping to see a new episode.
It essentially starred OoT Link as a teenager, and the very first episode featured Link and the Kokiri (including Saria and Mido, who were his friends, and were also 15-16 aged physically) doing a race in the Kokiri forest swinging through the trees. Of course, as Zelda plots do, Link finds out he's not Kokiri and that he's got an entire destiny ahead of him! Also he periodically gets visions of his other lives (those of Link from other Zelda games). Anyhow, the final episode (or set of them) I was able to watch involved Link entering a tournament/battle for the right to be granted the title of Royal Knight or something
(Basically, he needed to see a history book in the castle archives that can only be viewed by the royalty or the royal knights. And to become a royal knight you either need years of training and starting as a general guard member/soldier, OR you can fight the strongest of the royal knights, where you'll be granted the same title if you win)
Anyhow, he got his ass kicked by the champion and got his sword arm cut off, so that final episode I saw ended with Zelda at his bedside fixing his arm problem
I lost track of this series years ago, can't seem to find it if I tried. The only other thing I know is that the youtube account had one other video relating to the series, which contained the funniest submission they saw for people who applied to be voice actors for it (featuring a person doing their best Talon impression)
Mostly I'm saying all of this because I don't want to forget and I'm just kinda reminiscing, but there is a little part of me who hopes someone else knows what I'm talking about 😂
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oblako · 10 months
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she is just a girl who is so so scared </3
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widowshill · 3 months
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VAMP ROGER AU QUESTION! how would he and barnabas interact together (if they ever interact)? :3 💜
tagging @tortoisesshells because she's my co-conspirator <3
excellent question! this family and their sharp-toothed men will be the death of ... well, several community members of Collinsport, i suppose.
to start — Barnabas gets out of the box slightly differently than in canon, which colors his relationship to Roger and the rest of the household. Roger kills Willie after his attempted assault on Carolyn and Vicki (who is, by that point, his wife); Willie's mysterious disappearance and Roger's suspected involvement makes Jason that much more panicked, desperate, and correspondingly aggressive. Liz goes searching for the lost family jewels in a last-ditch attempt to buy Jason off, and, inadvertently, lets their ancient family sin out of the tomb.
ergo she's made Barnabas' thrall instead of Willie, but this goes unnoticed for a while — even though her brother would, in theory, recognize the signs, and his suspicions are raised, but she's already acting so much unlike herself with Jason around that he doesn't suspect anyone else of doing her harm. yet.
at the start, he and Barnabas get along very well, even before they discover their shared affliction: they're both relatively sophisticated, well-traveled, intelligent people, and for all that Roger decries Liz's emphasis on the Collins name, he leans towards familial connections instinctively (Roger hasn't got much in the way of friends outside of the house even in canon, and he's even more isolated as a vampire).
after he finds out Barnabas is also a vampire, things get a little more complicated, but overall, they're still friendly. Roger doesn't have much sympathy for Barnabas' relentless self-pity and decrying his doomed fate to live as a monster, because Roger on the whole enjoys his vampirism and has made a decent un-life for himself out of it (thanks in no small part to Vicki). but having someone like him around is a comfort in ways he wouldn't have expected, he's no longer solitary or uniquely monstrous out of the Collins family, he has someone else around through the night, and someone who understands the sufferings of bloodthirst and being shut out of the sun.
furthermore, Roger's very much interested in his family history and stories of the past, the building of Collinwood, Jeremiah's ships – and Barnabas was there. there's potential for some very interesting conversations about the past, and the arc of the Collins family history to the present, not to mention literature, travel, fashion, politics and the rest. Roger's his cousin's mirror in modernity in many ways, and that's something potentially interesting to explore: the world changes around them, but Collinses do not.
as an aside, they both have a funny sort of relationship to Burke. Barnabas hates him for his resemblance to Jeremiah and envies his friendship with Vicki and thinks he's crude, and Roger ... well. it's complicated. it's closer to antagonism than not, and Burke has tried to kill him once in this au, and Roger resents his flirting with Vicki, but then there's everything else with their past. so I don't think Barnabas' treatment of him would sit particularly well with Roger, he'd take the attitude of hey, only I can be a dick to Burke >:(
the definite fracture point is Barnabas imprinting on Vicki. Roger's already jealous and possessive by nature, and it's amplified by the supernatural nature of his relationship to Vicki (being closer, bodily and mentally; being necessary to each other; being, quite literally, sustenance) so he's already a little on edge when Barnabas starts paying attention to her, giving her presents, and appreciating the scenery — Barnabas doesn't, exactly, tend to have much in the way of moral inclination to leaving women alone when they have prior engagements, but it's fair to point out the irony of everything Roger was doing with his bloodbag governess when he was still very much a married man.
anyway: Roger finds foreign bite marks on his wife's neck, and he's understandably immensely upset by this. partially out of territorial sentiment, but he also knows Vicki, and he knows that she wouldn't have invited another vampire willingly — which means that she was forced, or hypnotized, or attacked in secret, and there's only the one potential suspect. this is already enough to lose his good will, but he might have been willing to let Barnabas go with a "hands off," had this discovery not lead to finding out what he'd also been doing to Liz. the combination of the two is unforgivable, and it's Barnabas' error to have made an enemy who is very personally aware of all his vampiric weaknesses, and Burke's already carved a stake.
#THANK YOUUUU for the question :D i love talking about this au kskfgd#devilagent#vamp roger au tbt#➤ answered. ┊ Collinsport 4099.#i do think the barnabas and roger relationship is an interesting one even though there's not much going on there in canon.#(canonically speaking roger is just sort of... there? even during cassandra he doesn't ever pity him for being a victim in the scheme;#it's grrr angelique is here messing with *Me* again. who cares about my oblivious dumb blonde cousin)#but there's a lot of parallels going on there which I never shut up about: the way that roger will drain life from a man#to preserve his own; or manipulate and throw others (vicki) under the bus;#or makes david (not biologically in human reproduction) into a monster just like him — forming him and burke in his image.#roger is Modern in ways that barnabas is not — the sports cars; the en vogue suits and turtlenecks; his flippant relationship with his vows#and his (relatively speaking) more-or-less open queerness.#but he's also a creature out of the past; an antiquated speaking pattern; an embrace of old family stories (particularly tragedies);#not to mention he plays the role of a byronic hero practically straight out of the novel just without any sideburns.#roger simultaneously wishes to be free of that family root system; but falls back on it in desperation because it's only because his#ancestry and family wealth and power exists that *he* exists at all.#and in the same way that joshua cannot shoot barnabas for becoming a monster; neither can liz condemn her brother for his manslaughter#(or david for patricide)#but even though they don't die; they are exiled — to the tomb; to augusta — and return as mere shadowed and monstrous versions#of their former selves.#many of the differences between vamp roger and barnabas I think can be partially explained by: roger did not have the 150 year gap between#being turned and coming back; he returns to essentially the same world he knew just ten years ago#and; two; that roger has his great yearning love *after* he's turned; and not before.#there's nothing about his life with laura and david that he particularly mourns or wishes to recreate.#and; as already noted; roger has vicki — who serves as necromancer;#which... I suppose parallels julia; in an odd way.
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starlytenight · 1 year
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Been seeing a lot of Mirror World stuff on my feed and wanted to doodle up some of my own DMK's angst c:
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espectres · 6 months
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Shou is what you get when the shounen protag doesn't get a good mentor. or a mentor at all
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choctalksalot · 1 year
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i think homestuck is pretty neat because all of the kids (and trolls, im using kids loosely) have this way of introducing themselves where they project an image of who they are/who they want to be, while also having a certain degree of self awareness on how much they actually embody that image. and under all of that a whole different version of themselves that they Actually Are that is usually a thousand times more lame, and more interesting because they're just kids. just a bunch of video gaming nerds. but by being those things, they're people, with flaws in places they may not expect and parts of themselves they misinterpret
so even on the things that they're self aware about, oftentimes they're also wrong about it to some degree, either by playing it up, brooding in in their flaws "i can't fix myself i am #brocken" style or closing their eyes to an underlying problem, sometimes being completely aware of it but burying it regardless
just. god !! it's so chewy. it's the basics of how any reasonably intelligent people would act and interact, i've seen it in media so many times, but there's something about how self-aware all of the kids are, how that awareness is still flawed, and how it reflects in all of their interactions that just Gets me so hard.
it might have something to do with how homestuck itself is a game about growing up. maybe it's how the narration itself embeds into the kids' perspectives and how it literally laser-shoots the image they each want to project into your head first through a mode of storytelling that is usually regarded as Correct And Trustworthy, then you get to pick and peel back each of the things they said. hold it up against their actions. the things their friends say, the things they themselves later admit, and it's still never a complete picture. nothing presented comes from a completely reliable narrator. not the characters, not even the narration itself. you have to break them down and deduce and discuss and still never have the full picture, there is always more to think about, there are always more layers to see.
they're all different degrees of aware in their self-perception and that awareness itself has different degrees of accuracy. sometimes that awareness is muddled through a separate perception of them through their ideals. it changes as they change. they understand, they repress, they dramatize and downplay and are so erringly knowing of themselves, it feels so real amongst all the utter bullshit that is homestuck itself. absolutely bonkers. real person-y thing that exists in every character everywhere to some extent but i've never been so aware of it
is layered. onion of mental illness. and when you look at them again you still see just a bunch of kids who played a game together. i think that's pretty neat
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tovaicas · 11 months
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I think the main reason the way the dravanians are handled (other than the kinda shitty implications of this game wanting to have its cake and eat it too re: the dragons, so that it doesn't have to engage with the honestly terrifying and extremely sad plight of the dravanian horde so that the player can still have mindless dragons to fight that you don't have to feel bad abt killing) annoys me so much is that heavensward had an honestly good curated experience of you learning gradually and then all at once just like an ishgardian would that the dravanians are real people with lives, families, customs, and dreams and not the mindlessly hyper-violent animals you've up until anyx trine you've been made to believe they are, something that is started in ARR with midgardsormr but really hammered home that all the dragons, even the ones you've killed, are sentient, intelligent beings with lives and many simply want quiet lives away from the war and don't want to lose their children to it. up until then you've been made to fear dragons and think of them as deserving of violence in turn simply for being what they are under the assumption they're mindless swarming beasts...just as the ishgardians do. heavensward does an honestly very good job of mirroring the ishgardian mindset and viewpoint of the war to you so that you can experience what ishgard feels when the truth is finally laid out for you.
but then as soon as we get anywhere close to actually engaging with that nuance, with what that says about the situation of the dravanian horde and ourselves, combined with the previous, initially offhand lore that the dragons literally cannot ignore the calls of their sires (which is the entire potential crisis that drags aymeric in for his first on-screen appearance, because midgardsormr can drag every dravanian currently alive into the war if he wants) and that maybe this is a far more complicated and tragic situation for all sides than we initially expected, and that maybe nidhogg's brood suffers in a way that's actually very similar to the ishgardians - we drop all of that. we drop it so that we can have an enemy in dungeons we don't have to feel bad about killing, so that we don't have to feel too uncomfortable with our actions or with running these two dungeons.
#saint.txt#spoilers#major spoilers#ishgardposting#long post#like I cannot reiterate enough that neither the vault nor nidhogg are the 'good guys' in this situation.#nidhogg's anger is justified but some of the things he has forced upon the horde (most of which are his own children) are arguably worse#than the vault's crimes. the dravanian horde literally cannot resist nidhogg's war song without literally losing their entire selves.#nidhog's literally engaging in the selective breeding of his own children. the horde - MOST OF WHICH ARE HIS KIDS - are just weapons to him#not to mention the pure horror that comes when you realize a not-insignificant portion of the horde are transformed ishgardians#many of whom are unwilling dravanians who are also not going to be able to resist nidhogg's call to war.#like the tone difference in some parts of HW is staggering. one daily in anyx trine has you chasing around a dravanian child in#what he thinks is a really fun game of hide and go seek and he plays just like literally any other kid would. it's humble. humanizing.#and then you load into sohm al or ESPECIALLY the aery and you're killing dragons in their own homes and sacred spaces#many of which ARE actual children like with whelp models and everything and there's just no commentary.#dravanians are people except for the ones we've inexplicably decided are mindless and Okay To Kill - many of which are children.#tioman is presented is irrationally angry but she had a point. you invaded a sacred place and just started slaughtering indiscriminately.
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theloveinc · 1 year
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i'm glad i'm not the only one who sees miguel's character hard to capture . i find his character so interesting, interesting enough to watch a hour long analysis vid on yt abt it since his motive for catching miles slowly dissolved into jealously and anger. by for the love of god if u pointed a god to my head and asked me to write abt him i'll say shoot me.
LITERALLY‼️‼️‼️ I love him and his story BEYOND WORDS and yet… we never actually see him in a situation where he’s not motivated by something very titular to his storyline (vs. his character). And ofc it’s a movie so like, we can’t know every single moment of his life (and in fact, we do get very important reactions)… but at the same we ALSO know he’s actually quite humorous and snarky and a lil goofy, too, and CAN BE SO SWEET LIKE WE LITERALLY SEE WITH GABI…
But how does one capture that without making it OOC given the ENTIRE STORYLINE???????????? Just, two coexisting things that don’t really fit without so much thought and detail, and while I love that aspect, it’s also ARGHAHSH when it comes to writing him in non-battle / ATSV circumstances :(((
Cuz he’s so complicated and multi-dimensional LOL (and we have yet to see every facet) that writing about him fucking and cuddling and really ANYTHING could just be about any ol’ fictional man……..
IT MAKES ME SO RAWWRRRRRRRRRRRRRRRR can’t believe u watched an hr long YouTube video tho LMFAO I hope it was on 2x speed
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c0rpsedemon · 1 year
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if you like how the mechs interacted w like. the way stories are told and repeated and repeated and how that affects the people they're about At All you'd LOVVVVVE fate bc it does the same thing just 100x more explicitly
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apollos-boyfriend · 8 months
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SPARKLEZ!
You wouldn't believe the things I've seen. Or maybe you would. What do I know?
Worlds upon worlds of wonder have embraced my many selves. I'm living a thousand lives at once. And those are just the lives I'm aware of. For instance, in a place called Middle Earth I am reborn a beautiful elf queen. And under the ice shield of a moon called Europa I am a strand of plankton. And in a world we both know well, I'm a bunch of little girls who look just like me, and maybe other things too... Anyway, my umbrella consciousness has reformed for just a moment; my caretaker, in his mercy, has allowed me to show you these things.
But you definitely won't believe the most amazing thing I've seen. Lately I've been looking through a window... A window into bygone years. A man sits in front of a screen, speaking his soul to the world while playing a game. I think I know who he is!
I see this man forming friendships with those who also speak to the world. I know who they are too. They project themselves as tiny box figures into a world made of boxes. It's so much less detailed than the world where the man and his friends sit. I would not have known Ruxomar and it's sister dimensions to be so childlike in appearance except by this contrast!
The days go on as the friends play. The boxlike world is ruled by two gods. Of course I know who they are. The man is faced with a choice between the two. His life is riddled with choices! And like the stubborn idealist he is, he carves out a middle path. He'll take neither god. He'll have a goddess all to his own.
He created me.
A man named Jordan Maron created the goddess Ianite in a world beyond worlds. And Jordan Maron looks just like you. He is one of your countless alternate selves. He looks so much less boxy! I think that if I did not already know you and Spark so well, I would call him my favorite version.
Now I grasp the truth I have been seeking all my life. I have see what is above gods. It is ____________.
My umbrella consciousness won't hold much longer. Let me say a few choice words before the final goodbye between this version of you and this version of me. Thank you for choosing to create me. I believe that had the other you not made that choice in that far off world, none of my present selves would exist. In a strange sense, you are my god. Thank you for believing in your creation enough to make it real. Thank you for continuing to love me and make choices for my wellbeing. I hope another you loves another me in another world soon.
If Jordan looks out the window one of these days, he might be able to see me.
Not even creeping. Just fyi.
Forever Your Lady
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orbeater · 3 months
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I've been desperately wanting to write a fanfic about those two just typing out an essay dont feel enough anymore
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musubi-sama · 3 months
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Papa Mama, Kiss!
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Nanami Kento, girl dad, and how the small commands an almost-2year-old can etch into his heart.
A/N: Thanks @pseudowho for the gentle nudge to write this one out. And for everyone else, if it's not obvious, based on real events.
WC: 1.4K
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Fatherhood, raising and nurturing children to become their best selves. To give them wings and teach them to fly on their own. This is what Nanami Kento dreamed of for years. But almost two years in, his daughter was testing his last thread of patience.
“Papa, milk!” Kento returns with a glass of milk.
“Papa, tea!” Kento blinks, and returns with a glass of tea, finishing off the milk for himself along the way.
“Milk?” Kento sighs. Just as he starts to lift himself from his chair, you put your arm on his.
“Sweetest, could you take a sip of the tea first?” you offer the glass to your daughter, and she happily starts to drink the water, quickly emptying the cup. Sufficiently satiated, she goes back to eating her lunch.
You shoot your husband a soft smile, you’re met with a weary, but loving gaze in return. Features worn by time, bolstered by love, and cut by the effort of child rearing.
You both had done your research, coming to similar conclusions with differing approaches on how to tackle the approaching “Terrible Twos.”
Kento couldn’t understand the parenting blogs, as they made any solutions to challenges seem so…. simple to solve.
“Guaranteed to solve purple crying with one simple trick!” “Sleep training made easy! You’ll have quiet nights in less than a week!” “10 steps to handling a temper tantrum in public. Number 6 will surprise you”
But every solution seemed to be milquetoast, at best, and unhelpful at worst. But almost two years in, he started to get the hang of things. The secret is that his daughter was her own person and required him to think on his feet. And despite the new levels of exhaustion he had reached, especially in the early days, Nanami Kento was euphoric to see his daughter every morning. He missed her in the depths of his heart every second she was at daycare, or even just with you running errands.
Kento was a modern dad, bucking the trend by taking the full year of paternity leave along with you. Reassuring you that there would still be an open spot in daycare once it was time to return to work. And he was right. He helped fill out the pages and pages of paperwork. And choosing the 13 facilities to rank in hopes you were offered a spot at your number 1? Of course, your salaryman husband excelled at sorting the data and organizing the thick booklets of information.
When it came time to drop off your daughter on her first day, and it was only for two hours, you both arrived with big, nervous, first-time parent jitters. And were the only full family there in the morning drop off. The other parents sharing knowing glances at you and Kento fumbling clothes, trying to find the bins you needed, almost dropping the thermometer, and giving maybe one, two, three, too many kisses to your daughter as you handed her off.
The walk to the local coffee shop was filled with dreams of what fun your daughter would have with her class. Kento was hiding his nerves well, but you could see right through him. You saw the tremor in his hand, the nearly imperceptible gravel in his voice. He didn’t hold back for the other parents’ sake; he’d never do that. But he didn’t want your daughter to catch his nervous and scared energy. He knew if she felt his anxiety, it would make handing her off so much harder. He couldn’t bear to hear your cries of separation.
So, when you both returned two hours later, Kento lit up with the biggest smile and the most eager arms as the workers handed your daughter off to him.
“Oh, my love, I’ve missed you! What did you play with? Who did you meet? Please tell me all about your day, spare no details,” your doting husband cooed at your one-year-old. He continued an entire conversation with her, even if words didn’t form from the baby babble.
You spoke with the workers to understand how she fared for the short visit. They told you how she didn’t cry not even once. And how tomorrow your daughter can stay even longer, through the morning snack. It made you so happy to get such fantastic feedback.
After a few weeks, you all settled into a lovely routine. Both of you working from home left flexibility for drop off and pick up. And as your daughter became more capable of bigger play times, Kento would take her out to the local park so that you could make dinner most days. You loved the peace and quiet, he loved the bonding time.
As your daughter’s language built up over the months leading up to her second birthday, she was beginning to string together commands. Able to ask for help, food, drink, toys. She even started to command who could sit next to her and then tell them to “moot (move)” away and a new person would be not-so-gently asked to sit next to her.
“Papa,” she would point to a spot on the ground next to her, in the middle of the playground. And Kento is not the type to ignore the requests of a child. He took a polite squat next to your daughter, waiting with bated breath for the next command she would give.
“Mmm. Ah…up,” she reached her hands up in the air.
“Do you want up?” Kento reached over to lift his little one up in the air with a light, controlled, toss.
“Papa!”
You sat on a nearby bench watching, camera clicking over and over, catching the precious moments to share with your friends and family across the world.
That night ran like every other, a well-oiled machine. You took a bath with your daughter, Kento took her for a fresh diaper, clean pajamas, and to help him make, and for her to drink, the nightly milk bottle.
And the final step, you welcomed a sleepy toddler into your weary arms. Tonight, she was laden down with her stuffies of choice, a small Sylveon and Doraemon.
“Okay, let’s cuddle up here, please,” you coax a sleepy toddler into your lap and to lay against your chest. It seems like every day it gets harder as she grows bigger. What happened to your teeny tiny bub?
“Good night, I love you,” Kento leans down to give a kiss to the tiny (well, not so tiny anymore) forehead. “And I love you,” he leans over to your waiting lips as you tilt your head up. Every night you get a soft, but gently urgent kiss from Kento.
“Papa iss?” you both break from the kiss to hear a tired request. Your daughter had sat up from your chest and looked expectantly at Kento.
“Of course,” he leans down for another kiss, this time her cheek. A satisfied smile spreads across her face.
“Mama iss?”
“Yes, love.”
“Mama papa iss?” and you looked up at Kento to make sure you heard her correctly.
“Did she…?”
“You heard her now,” and Kento leans down for another kiss, this time he lingers a heartbeat longer. As he pulls away, in the dim haze of the nightlight he catches your waterline beginning to fill.
“Oh, baby, you’re so sweet,” you coo at your daughter, pulling her into a tender hug.
“Good night, you two,” Kento is standing by the door, soft smile from lips to eyes. He slips out and gently shuts the door.
After you spend a few minutes cuddling with your daughter, you gently lay her in the crib and quietly slip out of the bedroom, leaving her to take the last step to dreamworld.
You sit down on the couch next to Kento. Still feeling the buzz from twenty minutes ago, he reaches over to cup your face.
“How are you feeling?”
“I am going to ride that high for weeks. I can’t believe it,” your eyes can’t hold back the tears of love and happiness. You feel every bit of the dichotomy between the hard moments and the soaring highs of happiness.
Kento could feel his heart grow and swell. The small command would replay in his mind until his dying breath. It would be a story he shared as the father of the bride. An endearing tale he treasured, a memory he could rely on to get him through overtime.
Coaxing you into his lap, Kento presses his lips to yours much more urgently than the last kiss.
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fatuismooches · 1 month
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cor meum, manus tuas.
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synopsis: After your illness strikes again, Dottore decides to gift you a failed experi-, a new companion in order to soothe your injured heart.
includes: dottore w/ gn! reader
notes: A cute fluff fic where Dottie gives you Foxttore and the pufflings as a pet (the blue monster creature from Nahida's fairy tale.) He loves you a lot. Really just pure fluff and Foxttore getting on Dottore's nerves. Enjoy!
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For as long as Il Dottore had known you, you had always been one to suggest things that he had no interest in. It was a habit of yours, and sometimes he’s not sure if you’re being genuine about it or if you simply want to rile him up, as you usually do.
One such example was back in the Akademiya when the two of you finally successfully reversed-engineered one of those machines after a painstaking amount of work. It was arduous and tiring, but immensely rewarding. Oh, he had so many ideas and things to do now, but you- you had other plans.
“So, now that we’ve got it under our control, I think we should program it to have some new tricks.” Zandik had paused at your words, as for once that was a good idea. He wondered what the limit of such a killing machine could possibly be.
“Go on.”
“Alright, imagine this, it’s about to swoop in and land the finishing blow, but instead, a whole bunch of confetti pops out and-”
“No.”
“You can’t even pick up a sword properly. You know nothing about fighting like I do! Just hear me out, it’ll be a great distraction because they’d never be expecting that, and boom, that’s where the real attack comes in.”
“No.” (Later on, he found out that you’d programmed the thing to have a single flower shoot out, just for him. He swiftly removed it after you were done laughing.) 
Or when you had begged and pleaded with him to let you teach him how to cook, just once. It was no secret you were always the one on cooking duty during the Akademiya, for he had a severe lack of skill for it. Furthermore, Zandik had no interest in it, not having the time or patience for something just meant as sustenance. You, however, were insistent on at least teaching him the basics, for it was no way for a student to live (according to you.)
The slicing and dicing went well enough, but the moment you turned your back for a few moments, he had somehow set the smoke detector off, and the Akademiya’s dorm director gave you two a good scolding. You learned your lesson after this particular incident, but from your giggles, he knew you didn’t feel an ounce of regret.
Your antics were truly something he wouldn’t get used to. And now, over four hundred years later, your teasing nature had remained the same, only that it became more verbal as you didn’t have the strength to pull off your elaborate plans anymore.
Which is why lately you had been clinging to him with pleading eyes and a jutted lip, vehemently asking for a pet despite his numerous rejections, going so far as to try and recruit other segments (who, unfortunately for you, did not join your cause.)
“Please honey, my darling, my beloved, my-”
“My answer is not going to change, [Name]. I will not tolerate anything running around and causing a mess.”
“Aww, but come on. I know you love cats. I know you secretly pet them when no one’s looking. I know that-”
“That’s enough from you. Now, will you sit or should I strap you down instead?”
That line of conversation persisted for a while until you mostly gave up, only throwing the idea in from time to time with a hmph. But now, he was uncharacteristically wondering if there could be a solution to this problem. 
Lately, you had been confined to your bed and room, too physically weak to move around much. He and the segments had done their best, as they always do, to take care of you, but one did not need to be a genius to know that you were feeling down. Not only because of the aches your body gave you, but also because you were lonely for most of the day, seeing as his other selves were usually too busy to spend an adequate amount of time with you. Once again, despite his lack of care for the emotions and feelings of others, he could see straight through your feigned expressions of nonchalance.
Dottore hated it when you pretended around him.
He could raise the topic but it would probably make matters worse. Instead, it was much more logical to work toward a solution for the issue - the solution being a companion to keep a smile on your face, and your mind at ease. Now, an actual pet probably would be a hassle to maintain in the lab, knowing the kind of activities that were… well, unsafe to say the least, so he put that possible solution to the side for now.
Initially, he sought to create something mechanical, having seen the mechanical animals from Fontaine. Of course, his creation would be far superior, and it would be quite helpful with your condition and all. But upon further thinking, knowing your tastes… you’d probably prefer something softer, considering how much you liked to cuddle him and your plushies. 
It was a conundrum the scholar found himself in, making his darling lover happy was not something that could be so easily scientifically concocted like the rest of the conclusions he reached. It required much more than simply following the lines of reason. Perhaps that’s why Dottore often struggled with it. 
Yet he did not have the luxury of time to continue pondering, for he did not want to leave you by yourself for much longer. And so he continued to sit at his desk, his hands automatically filling out paperwork while his mind was focused elsewhere, still thinking about what he could possibly gift you. Something warm and cuddly with the ability to communicate with you to some extent…
That was when he remembered something he created long, long ago.
The memories of that creation came back to him rather quickly once he remembered. Dottore remembered every experiment he’d done, but some were just not very special or successful and lingered very little in his mind. This was one of those unnoteworthy results. It was no secret that he was known to… play around with the concept of life, ignoring the rules that guarded it so strictly… and it was this idea that led to the birth of a creature, one that certainly did not belong to this world.
It was a monstrous, furry black thing that hid its true self with some kind of suit, its lone eye bright and red. It hadn’t been the first time his experiments led him to the unknown, but this… was just something he didn’t care about at all. After a few tests on the creature, he lost interest rather quickly. It was the farthest thing away from the life Dottore wanted to toy with. In fact, he had planned to dispose of the thing, but the creature seemed to understand his words more than he anticipated. It quickly scurried away, creating chaos and knocking down almost everything it could, skillfully making its escape.
Dottore had contemplated searching for his odd creation but decided that it wasn’t worth the time or energy. Judging from the distaste it held for him, it probably wouldn’t come around anyway. So, it could exist in the far depths of the lab for all he cared. It wasn’t like this was the first time he threw things into the back and forgot about them. Now, he was rather pleased that he didn’t get rid of his experiment. He had known you for long enough that he was sure you’d find such a thing cute, for some reason. It checked the fluffy and easily holdable boxes too. His only question was whether it could be alive after all these years… well, it was certainly worth a shot, seeing as his solutions were limited.
The answer to Dottore’s question was a yes. It had unfortunately taken much longer than he’d liked to search the dusty rooms (although admittedly, he had gotten a bit distracted with reviewing the old things he dumped) but at long last, he had found the round creature peacefully dozing without a care in… some kind of bed it had crafted with a bunch of papers and black fur. It looked perfectly content… in all honesty, Dottore was a bit interested in what it had been up to all this time. Maybe it held more scientific value than he thought… 
Regardless, in one swift motion, Dottore grabbed the creature by the scruff of its neck and it immediately awoke, attempting to scramble away. Once its single eye laid on the man who so rudely interrupted its sleep, it blinked, before multiplying its strength to escape, even trying to scratch him, but to no avail. The Harbinger’s grip was far too strong, of course. Meanwhile, Dottore had already lost a bit of patience from the creature’s incessant movements.
“Stop that,” he demanded sharply, and the critter instantly went still as its eye continued to stare at him completely widened. Dottore smiled, which felt rather eerie and frightening to the oversized creature.
“What, did you think I came all the way here to finish the job? Oh no, if I wanted to, I would have done so already a long time ago. Instead, I have another use for you. Something that will benefit both of us. I’m sure you’ll agree,” he hummed as he turned to leave the room. But as he took a single step, he found himself stepping on something soft. Curiously lifting his foot, he looked down to see a small, black, round ball of fluff staring at him with a red eye identical to the creature he held in his hand. And then another came into view.
… And another. Soon at least over a dozen had popped out of the shadows, all watching at him with anticipating eyes. He had forgotten these balls of black fur were also a byproduct of creating the creature. Now quite a few had surrounded his feet and were hopping up and down, attempting to climb his pants, which he quickly shook off with a scowl. Well, it looked like these things were going to follow him regardless of what he said…
“If you all are going to follow me, be prepared to make yourself useful,” he sighed in exasperation before finally leaving, stepping on a few more in the process. (The usefulness in question, was making sure you’d be left with a smile.) Based on the odd squeaking noises the smaller creatures made, they seemed to be on board with the idea. 
When your husband suddenly presented you with a gift contained in a rather large box, you were a bit surprised. Not because you were receiving a gift, but because of the size of it. Normally, he would give you small trinkets and such, things he’d thought you’d like (that had no real purpose to him, retrieved solely for you. Yes, he was very cute unintentionally. You had a little shelf for his stuff.) But you had no clue what he could have possibly gotten for you that warranted the need for such a big container…
You had long discarded your book in favor of new entertainment (you were reading the same sentences over and over anyway), your hands gliding over the rough material. Dottore was looking at you expectantly, having barely said anything besides shoving the thing on your bed, with a simple “for you.” You couldn’t help but chuckle, your chest getting a bit lighter from the previously stuffy atmosphere dissipating.
“Are you going to explain yourself or leave me guessing as to what I’ve done to receive such a thing?”
“You have been lonely and tired, and I seek to alleviate your pain. Yet there are certain things I cannot always do, which is why I found a solution,” he stated simply, pushing the box closer to you as if it was no big deal. Your eyes widened as your jaw hung, speechless, before you sent a small, teasing smile to your husband.
“I… well, who knew you could be such a considerate man? Keep that up and you’ll make me blush.” You couldn’t help but heat up a bit from his concern, although he didn’t say it outright. And you didn’t really have it in you to deny his words too, he was right after all, you have been lonely and tired from being cooped up in your room all day.
“Still, I want a hint! Ah, it’s too heavy for me to even lift up…” You couldn’t guess what could be in here. “Could it be the latest new novels from Inazuma?”
“No, but those are on the way. It’s something more-” At that moment, the box slightly shifted and you blinked in surprise.
“Oh, oh! Are these new models of Beta’s miniature Ruin Machines? Did he finally make the Ruin Sentinels series?” In truth, initially, the segment wasn’t interested in creating such pointless machines, but after you oh so innocently challenged him to make them movable and fit in the palm of your hand, he took the bait and presented them to you smugly. Needless to say, you very much liked your little collection of action figures, and you were hoping he had finally made ones that could fly.
“No, it’s-” Once again, he was interrupted by even more dramatic shuffling, thumping echoing loudly from inside the box which made you scoot back a bit.
“Dottore, you sure whatever’s in here isn’t going to attack me…?” Your voice was more lighthearted than worried, but now you were squinting at him a bit suspiciously. Dottore’s expression remained unaffected, but inside he was the slightest bit annoyed. He had told those damn things not to move around. Thankfully, a sharp slap to the cover of the box caused the movements to cease, and he only smiled at you once again.
“As I was saying, it’s something you have been asking about for a long time.” He watched as your face turned thoughtful, fingers drumming when suddenly it became very obvious as to what it was. 
“Is it… is it what I think it is?” He found your expression rather amusing as he witnessed your eyes becoming sparkly with joy.
“Go ahead,” Dottore motioned and you wasted no time pulling the cover off the box, your eyes meeting a furry, blue creature whose lone eye gazed up at you curiously. You blinked at it, and it blinked back at you, but you had no time to say anything before some other unknown creatures began pouring out the box and spilling onto your bed, some crawling on your lap. This was certainly not the average pet you had expected… but you were not complaining. These things were the cutest - not to mention the little strand of hair on the top.
“Dottore,” you giggled at the fluff tickling your skin, “what exactly are these- oh!” Your words were interrupted when the larger creature suddenly jumped out of the box and launched itself into you, pawing your chest. You reciprocated the attention in delight, giving it numerous head pats and taking a closer look at it. Most of its soft fur seemed to be blue, although its head was black, and its beak was harder than the rest of its body. Regardless, it was completely adorable, and it seemed to like you very much.
“It is something I created in my lab during one of my experiments. I figured it would be something you’d enjoy.” You lit up, and the scholar couldn’t help but appreciate how you seemed to glow.
“You made these little guys for me? Oh, I always knew you could be such a romantic! I have my husband, my son, and now a cute pet. Isn’t it nice to see our family grow, Zandik?” He remained silent at your hastily made conclusion, deciding that the little white lie wouldn’t hurt, especially not when you looked this happy. After all, he imagined your response to him keeping this creature in the backrooms of his laboratory for ages wouldn’t be very well received, considering how attached you were to it already. Thankfully, you didn’t notice the glare the creature sent him either.
“Do they have names yet?” Dottore thought back to the string of numbers and letters attached to this experiment and opted not to disclose that, shaking his head. You hummed, trying to think of what name to bestow upon your new pets until you quickly came up with something good.
“Foxttore,” you stated firmly.
“Foxttore?” He repeated a few seconds after you, rather unimpressed.
“Yes! Because he looks like a fox, and he also kind of looks like you!” You playfully squished the creature’s cheeks.
“I bear no resemblance to that creature,” he frowned, immediately refuting your statement.
“Don’t look like that,” you teased. “It’s a compliment. You’re both cuties that are the same shade of blue,” you leaned in to kiss him gently, a simple way to silence him despite his vexation. “Now as for these little ones…” you thought once more as the black puff balls clung to your arm, Dottorelings… no, that’s too long… how about pufflings? Yes, that will do nicely!” Seemingly understanding your words, the pufflings began jumping up and down in glee. You then moved closer to the man and enveloped him in a hug.
“Thank you for this, Zandik. I am very happy,” you whispered quietly as you snuggled into his neck. It was the truth - you really were happy to have some company constantly around. Your husband returned the hug and you loved how his strong arms felt around you.
“Of course. But if they happen to cause you any… trouble,” he sent a look to the thing now called “Foxttore”, “be sure to tell me.”
“Aww, don’t say that. Foxttore is a good boy! Right?” You smiled brightly at your new pet, who was kneading the blanket, watching the two of you. The contrast between its creator’s less-than-pleasant face and your wide grin was stark and rather easy to choose from. It then hopped up and practically wedged itself in between the two of you, looking up to you with a pleading eye, desperate for attention. You squealed with delight and pressed the creature to your cheek, nuzzling against it.
When Dottore noticed the cheeky look his creation sent him, he wondered if this was actually a good idea.
Foxttore and the pufflings were the best and cutest companions you could ever ask for.
The pufflings were always scattered about your room, resting in different locations. You honestly had no clue how many there were, nor could you tell them apart, but you swore they squeezed through the bottom of your door somehow because sometimes they’d return with random items. They seemed pretty starved for attention… they even liked it when you squished them like a stress ball.
Foxttore was equally as cuddly, but also rather intelligent. He would fetch you items so you didn’t need to get up, and he could even turn a doorknob… you were fascinated. One of your favorite things to do was give him a note for him to deliver to a segment, and he would actually deliver it. (Said note usually contained you begging a segment to visit you, otherwise you’d die without their attention.)
After a lot of cuddling and rubbing, you found out that Foxttore was just a severely oversized puffling with four legs instead. That blue fur of his wasn’t even his, just a suit he wore. It was quite funny to see him without it on. It seemed rather shy without its fox fur, but with enough kisses, hugs, and reassurance, it had no problem lounging around without it.
You read them stories, showed them everything your room had to offer, placed some of Beta’s cute pink bows on them, bathed with them - you were starting to look forward to the day much more now that you could wake up to them.
While Dottore knew that you would get attached to the little monstrosities he gifted you, perhaps he didn’t anticipate it to reach this degree. Even after you had gotten well enough to stroll around the lab again, the blasted things were attached to your hip the whole time.
Visiting the segments? They would come up to you, caressing and teasing you with their deliciously infuriating small touches and kisses, and then all of a sudden a small crash would sound throughout the room, the culprit being Foxttore.
Visiting him? He’d have you on his lap, about to pin you to his desk, when he noticed the pufflings watching him from all corners of the room. It was maddening trying to chase them away, but then you’d get pouty about how the creatures didn’t like to be alone. (The only segment that the creature seemed to like was Zandy, although it had taken a while - a bit of scolding from you, and many offerings of food from the child to Foxttore had done the trick.)
As much as Dottore was glad your mood had improved greatly, admittedly, it would please him if he could just chuck his creations out into the Snezhnayan snow, just to finally get some alone time with you. But you loved them too much, so he resolved to resort to other means… eventually.
Over time, your pets gradually began to not hog your attention the whole time, but you were very insistent on helping Dottore and them become friends. It wasn’t very easy, however, they seemed to have some tension between them. You weren’t really sure why, but you still loved having them together.
“Dottore! Oh Dottore, you have to watch this,” you puffed out your chest proudly as Foxttore trotted behind you. Your husband looked at you questioningly before you spread your arms out, directing them toward the creature.
“I taught Foxttore tricks! Watch this! Foxttore, sit!” Your pet obediently sat down, his tail wagging (although you had no clue how that worked since it was just a suit…)
“Foxttore, spin around!”
“Foxttore, roll over!”
“Now high-five me!” Dottore watched in amusement as the blue creature followed your commands with ease. Perhaps it really was smarter than he thought. Regardless, all he cared about was that you were occupied with something, rather than being by yourself.
“Okay, now fetch Dottore’s secret stash of sweets!” At that, Foxttore began making its way over to one of the numerous bookshelves in Dottore’s office before the Harbinger quickly realized what you said, and stopped the creature in its tracks.
“I knew there were too many pieces missing,” he stared at you humorlessly, while you sweated nervously.
“W-What? You said I was allowed to take some!”
“I said you, not this… thing,” the man then picked up Foxttore by its strands of blue hair, which the creature fought at, and dropped it in your arms like it was some pest. “I’m moving it.” 
“Please don’t! I won’t do it again!”
The continued pampering of Foxttore had, unfortunately for your lovers, become a norm to see around the lab. He was a spoiled lil shit, in other words, who could do no wrong in your eyes… which is why every new thing you did had little to no effect on them anymore besides an eye twitch of annoyance and a promise to bully the creature later. The current situation was one such time. Dottore had come into your room only to see many abnormally small clothes scattered on your bed, with you in the center of it all.
“Oh Dottie, you’re just in time! Look at what I got!” You then held up Foxttore in all his glory, his new hoodie substantially thinner with different patterns, a great big smile on your face.
… It was only you who had the privilege of using his time like this.
“Now before you ask how I got these, I had them custom-made! See, I wanted to sew the clothes myself, but my hands have been too shaky lately and then you’d get all grumpy if I hurt myself with the needle, so I just asked Columbina to find someone for me and she did! She’s a great friend!” You continued to ramble on. 
“See, the poor thing gets too hot sometimes, especially when he starts running on our walks,” you said sadly, while he wondered how exactly you walked this monstrosity, “that’s why I got him different clothes! And they’re stylish too! Look, he’s even got pajamas! Don’t you think it’s cute?” You looked at him, your eyes sparkling and glittering with light that dazzled him.
In all honesty, Dottore didn’t really care about the little abomination of a creature. In fact, he probably leaned more into disdain for it. But what he did care about was you, and what made you happy, what put a smile on your face since he hated for it to be missing.
“I believe your definition of cute is rather unusual.”
“Huh? How could you not think Foxttore is the cutest thing ever? Oh… I see your game. You think I’m the cutest thing ever, don’t you?” You boldly teased him which didn’t phase him, only making a confident smirk grow on his face.
“I suppose that would be accurate, yes. Nothing else comes to mind that could be compared to your beauty,” he said smoothly, plucking the creature from your hands and dropping it elsewhere, which it clearly disliked, but he was more interested in your reaction. Your mouth slightly ajar, heat creeping up your face with a flustered expression, breathing speeding up a bit.
“A-As long as you’re aware,” you mumbled shyly, turning your face away, although your slight smile was apparent.
Needless to say, Zandik was always aware of his beloved.
You always loved it when you were able to leave the lab. Sometimes they were frequent outings, sometimes they were very rare. It all depended on how well you had been feeling lately. Today, you had finally been able to go out for a short walk with Dottore after so long. The cold air and snow had you shivering, but feeling the wind hit your cheeks was worth it. (And being able to cling to your husband was a definite plus in your books.) But you were still happy to come back home.
… Especially when you were greeted by your little friend.
As soon as you walked through the door, you noticed that Foxttore was impatiently waiting by the entrance. The moment he saw you, he sped toward you at light speed and pawed at your legs for pets, hopping up and down. You couldn’t help but laugh as you bent down to give him some attention which he happily reciprocated, but then he pulled away and started wildly running around the two of you.
“Aww, Foxttore is having zoomies!”
“… Pardon?”
“He’s having zoomies!” You smiled at your husband before crouching down, and your pet immediately ran into your arms and settled himself there as you picked him up. “Aww, you must have missed us so much, didn’t you?” You cooed as you rubbed his tummy, while Dottore merely stared at you blankly. The man then noticed the creature’s eye had narrowed into a half circle directed toward him as if to mock him. 
If there was a point system between the two of them as to who was able to steal your attention more, Dottore would sorely be losing.
It was one of the few nights where you were able to spend a night like most couples do at the end of the day - resting in the same bed with your lover. You weren’t even sure how you managed to do it this time. You thought it was probably due to your persistence but also that he was genuinely tired. (Well, he had been genuinely tired for ages now, but you were able to get him on a weak day, perhaps.)
You had always loved it when Dottore held you, even if it was slack or just one arm, you always felt safe. Protected. Warm. Happy. The feelings only amplified when both his arms caged you into his chest, which was the perfect place for you to snuggle. (Still, he’d never admit to being the little spoon from when he was a student.)
“Hey, Zandik?”
“Hmm?”
“Thank you for everything you’ve done lately, by the way.”
“Of course,” his answer was as simple as could be. He stroked your hair languidly, always one to brush off your thank yous.
“I mean it,” you wiggled out of his grip to look him in the eye, lip jutting out slightly.
“I already know you do. You do not need to keep saying it every time.” You pouted at his response. How else were you supposed to show your appreciation? You then grabbed his arm, which was surprisingly pliable, and placed his hand over your heart.
“Then let me know if you need anything from me. Anything at all. I have to pay you back eventually, you know.” Dottore looked as if he was enjoying himself.
“What do you propose? I’ll listen to your suggestions.”
“Well… I have kisses and cuddles as my expertise. I can cook and bake for you sometimes too… oh, but I can also try doing some of your paperwork! …What? You’re not impressed? I guess I can try to do some more… unsavory tasks as well. The Fatui agents listen to what I have to say quite easily,” you continued to chatter as Dottore’s fingers made their way from your cheek to your neck and then your collarbone, making you stammer at the sensation. “Hey, you’re not even taking me seriously, are you?” Your husband only chuckled at your furrowed eyebrows and grumbling.
If anything, he would want you to repay him by letting him see the faces you’ll make once you’re finally free of your illness.
“Anyway…” you squeezed his hand with yours that still rested on your chest, “You probably know this already, with that ever-calculating mind of yours, but you hold my heart in your hands. I’ll always be here with you.” It was a funny thing to think about, giving your heart to someone like him, in both a physical and intangible sense. Trusting him with your frail body, trusting him with your love, knowing he could squeeze it to a pulp if he wanted to. But he wouldn’t.
He would treat your heart with the utmost care and precaution, not daring to risk even the slightest harm to it.
Dottore stared at you for a few moments while you held his gaze, resolute on making your point known. Wordlessly, he began to move closer to your soft lips, intent on making his response to your statement physical. He was so close, his nose brushing against yours, and your warm breath on his. He was about to finally satiate his desire when-
Something was scratching at the door. Loudly, too. The sudden noise made you jump back and turn your gaze to the door. The Harbinger had a bad feeling about this.
“Did you hear that?”
“No.”
“You’re just lying now!” With a huff, you pushed the blankets off, much to his displeasure, and made your way to the door, opening it. There was Foxttore, making strange noises that he tried his best to mask as cries.
The bliss Dottore felt a few moments ago had turned to immense annoyance immediately.
“Oh, you poor baby! Did you have a nightmare or something?” You exclaimed before quickly scooping Foxttore into your arms and bringing him onto the bed. “It’s okay, you’re with us now…” You softly murmured, stroking it gently as you let it settle on your chest. Where Dottore’s hands should be right now, cupping your soft skin instead of that damned creature.
Dottore swore he was going to throw that thing out once you were asleep.
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reasonsforhope · 4 months
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"Since it was first identified in 1983, HIV has infected more than 85 million people and caused some 40 million deaths worldwide.
While medication known as pre-exposure prophylaxis, or PrEP, can significantly reduce the risk of getting HIV, it has to be taken every day to be effective. A vaccine to provide lasting protection has eluded researchers for decades. Now, there may finally be a viable strategy for making one.
An experimental vaccine developed at Duke University triggered an elusive type of broadly neutralizing antibody in a small group of people enrolled in a 2019 clinical trial. The findings were published today [May 17, 2024] in the scientific journal Cell.
“This is one of the most pivotal studies in the HIV vaccine field to date,” says Glenda Gray, an HIV expert and the president and CEO of the South African Medical Research Council, who was not involved in the study.
A few years ago, a team from Scripps Research and the International AIDS Vaccine Initiative (IAVI) showed that it was possible to stimulate the precursor cells needed to make these rare antibodies in people. The Duke study goes a step further to generate these antibodies, albeit at low levels.
“This is a scientific feat and gives the field great hope that one can construct an HIV vaccine regimen that directs the immune response along a path that is required for protection,” Gray says.
-via WIRED, May 17, 2024. Article continues below.
Vaccines work by training the immune system to recognize a virus or other pathogen. They introduce something that looks like the virus—a piece of it, for example, or a weakened version of it—and by doing so, spur the body’s B cells into producing protective antibodies against it. Those antibodies stick around so that when a person later encounters the real virus, the immune system remembers and is poised to attack.
While researchers were able to produce Covid-19 vaccines in a matter of months, creating a vaccine against HIV has proven much more challenging. The problem is the unique nature of the virus. HIV mutates rapidly, meaning it can quickly outmaneuver immune defenses. It also integrates into the human genome within a few days of exposure, hiding out from the immune system.
“Parts of the virus look like our own cells, and we don’t like to make antibodies against our own selves,” says Barton Haynes, director of the Duke Human Vaccine Institute and one of the authors on the paper.
The particular antibodies that researchers are interested in are known as broadly neutralizing antibodies, which can recognize and block different versions of the virus. Because of HIV’s shape-shifting nature, there are two main types of HIV and each has several strains. An effective vaccine will need to target many of them.
Some HIV-infected individuals generate broadly neutralizing antibodies, although it often takes years of living with HIV to do so, Haynes says. Even then, people don’t make enough of them to fight off the virus. These special antibodies are made by unusual B cells that are loaded with mutations they’ve acquired over time in reaction to the virus changing inside the body. “These are weird antibodies,” Haynes says. “The body doesn’t make them easily.”
Haynes and his colleagues aimed to speed up that process in healthy, HIV-negative people. Their vaccine uses synthetic molecules that mimic a part of HIV’s outer coat, or envelope, called the membrane proximal external region. This area remains stable even as the virus mutates. Antibodies against this region can block many circulating strains of HIV.
The trial enrolled 20 healthy participants who were HIV-negative. Of those, 15 people received two of four planned doses of the investigational vaccine, and five received three doses. The trial was halted when one participant experienced an allergic reaction that was not life-threatening. The team found that the reaction was likely due to an additive in the vaccine, which they plan to remove in future testing.
Still, they found that two doses of the vaccine were enough to induce low levels of broadly neutralizing antibodies within a few weeks. Notably, B cells seemed to remain in a state of development to allow them to continue acquiring mutations, so they could evolve along with the virus. Researchers tested the antibodies on HIV samples in the lab and found that they were able to neutralize between 15 and 35 percent of them.
Jeffrey Laurence, a scientific consultant at the Foundation for AIDS Research (amfAR) and a professor of medicine at Weill Cornell Medical College, says the findings represent a step forward, but that challenges remain. “It outlines a path for vaccine development, but there’s a lot of work that needs to be done,” he says.
For one, he says, a vaccine would need to generate antibody levels that are significantly higher and able to neutralize with greater efficacy. He also says a one-dose vaccine would be ideal. “If you’re ever going to have a vaccine that’s helpful to the world, you’re going to need one dose,” he says.
Targeting more regions of the virus envelope could produce a more robust response. Haynes says the next step is designing a vaccine with at least three components, all aimed at distinct regions of the virus. The goal is to guide the B cells to become much stronger neutralizers, Haynes says. “We’re going to move forward and build on what we have learned.”
-via WIRED, May 17, 2024
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