#interferon

[biology-geology-beaches-india]

The Science Research Notebooks of S. Sunkavally, p431.

[willowreader]

This analysis made it clear that the difference between those who were improving and those who were not was in the immune system’s interferon-led response to the virus. Interferons are proteins that act like the body’s alarm system against viruses and other harmful invaders. When a virus infects a cell, the cell sends out interferons to warn nearby cells. These nearby cells then prepare to defend themselves, making it harder for the virus to spread. All of these responses produce specific biological signatures that have been determined in various experiments and exist in databases.

This article explains how interferons in our cells can help some people recover from brain fog ir cognitive impairment in Long Covid.

[medicomunicare]

Autoimmunity crosses alteRNAtive threads: meet SLIRP and its mitochondrial businesses

SLIRP: an anomalous factotum on nuclear signaling SLIRP (SRA stem-loop interacting RNA binding protein) was firstly identified in 2006 and found to bind to a functional substructure of SRA called STR7. Steroid receptor RNA activator (SRA), the only known RNA coactivator, augments transactivation by nuclear receptors (NURs). SLIRP is expressed in normal and tumor tissues, contains an RNA…

[didanawisgi]

Spontaneous, persistent, T cell–dependent IFN-γ release in patients who progress to Long Covid

Abstract

After acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a proportion of patients experience persistent symptoms beyond 12 weeks, termed Long Covid. Understanding the mechanisms that cause this debilitating disease and identifying biomarkers for diagnostic, therapeutic, and monitoring purposes are urgently required. We detected persistently high levels of interferon-γ (IFN-γ) from peripheral blood mononuclear cells of patients with Long Covid using highly sensitive FluoroSpot assays. This IFN-γ release was seen in the absence of ex vivo peptide stimulation and remains persistently elevated in patients with Long Covid, unlike the resolution seen in patients recovering from acute SARS-CoV-2 infection. The IFN-γ release was CD8+ T cell–mediated and dependent on antigen presentation by CD14+ cells. Longitudinal follow-up of our study cohort showed that symptom improvement and resolution correlated with a decrease in IFN-γ production to baseline levels. Our study highlights a potential mechanism underlying Long Covid, enabling the search for biomarkers and therapeutics in patients with Long Covid.

[deinheilpraktiker]

Wie moduliert das ISG15/ISGylierungssystem die Infektion mit dem Vaccinia-Virus?

In einer aktuellen Studie, die im veröffentlicht wurde bioRxiv* Server zeigten Forscher, wie das Interferon-stimulierte Gen 15 (ISG15) an der Verbreitung des Vaccinia-Virus (VACV) beteiligt ist. Studie: ISG15 ist für die Verbreitung extrazellulärer Virionen des Vaccinia-Virus erforderlich. Bildnachweis: Kateryna Kon/Shutterstock Bei diesem Nachrichtenartikel handelte es sich um eine Rezension…

[ricisidro]

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Our first line of defense vs #SARSCoV2 are interferons, our innate immunity, a complex system not yet exploited for prevention and therapy. A great new review/perspective here @ImmunityCP | via Eric Topol @EricTopol

Innate immunity and interferon in SARS-CoV-2 infection outcome, published in Immunity on 06.18.23

[gregdotorg]

it wasn't immediately clear whose portrait this was in the Felix Gonzalez-Torres exhibition at the National Portrait Gallery. Usually the subject is in the parentheses after the "Untitled" title, but not this time. Ofc like so much of his work, it turns out it was a portrait of the artist himself. This is the 42nd version to be installed since 1989.

[wheelie-sick]

*my class lecture is about interferons and mast cells*

internally: I KNOW ABOUT THOSE MINE ARE BROKEN

I get so excited when I know stuff in the lecture like yeah I know what interferons are. I don't have any anymore! they're gone! goodbye and good riddance!

[colinwilson11]

The cGAS-STING Pathway: A Key Immune Surveillance Mechanism

The innate immune system provides the first line of defense against invading pathogens like viruses and bacteria. One of its key mechanisms for detecting microbial infections is the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. This cellular surveillance pathway plays a critical role in detecting foreign DNA from invading microbes and mounting appropriate immune responses.

How It Works

When microbial DNA enters the cytosol of host cells, it is recognized by the cGAS enzyme. cGAS has the unique ability to bind to DNA and produce the second messenger cyclic GAMP (cGAMP) from ATP and GTP. cGAMP then acts as a ligand to bind and activate the endoplasmic reticulum-associated adaptor protein called STING.

Activation of STING leads to its association with tumor necrosis factor receptor-associated factor 3 and 6 (TRAF3/6). This triggers a downstream signaling cascade involving the protein kinases TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3).

Phosphorylation of IRF3 by TBK1 causes IRF3 dimerization and translocation into the host cell nucleus. There, IRF3 induces the expression of Type I interferons (IFN-α and IFN-β) and other proinflammatory cytokines that signal the presence of invading pathogens to other cells and recruit additional immune defenses.

Role In Antiviral Defense

The cGAS-STING Pathway plays a critical role in the host defense against various DNA viruses like herpes simplex virus 1, cytomegalovirus, Epstein-Barr virus, vaccinia virus and HIV. Upon viral DNA entry in the cytosol, cGAS binds and activates STING to induce Type I IFN production. This initiates an antiviral state in infected cells and neighboring uninfected cells to limit viral replication and spread. Mice lacking cGAS or STING exhibit impaired IFN responses and increased susceptibility to infection by these DNA viruses.

Protecting Against Cancer

Aside from fighting infections, the cGAS-STING Pathway also acts as a tumor suppressor mechanism by detecting aberrant genomic DNA in cancer cells. Many cancer cells have disruptions like broken DNA strands that could lead to cell death if sensed by the immune system. However, cancer cells often develop ways to evade this cGAS-STING surveillance.

Studies have shown that loss of or reduced expression and activity of cGAS or STING promotes tumorigenesis in various cancer types like colon cancer and prostate cancer. At the same time, therapeutically activating the cGAS-STING Pathway seems to stimulate antitumor immunity and enhance the effectiveness of cancer immunotherapies in mouse models. This highlights the pathway's potential for developing new immunotherapeutic strategies against cancer.

Role In Autoimmune Disease

While the cGAS-STING Pathway protects against infections and tumors, its overactivation can also lead to inflammatory and autoimmune conditions. Defects that cause constitutive STING signaling have been linked to autoinflammatory diseases. Genetic mutations that make STING hyperactive and uncontrollable result in a group of rare hereditary inflammatory syndromes known as STING-associated vasculopathies with onset in infancy (SAVI). Patients with SAVI exhibit symptoms resembling systemic lupus erythematosus due to excess Type I IFN production.

Meanwhile, environmental and endogenous cytosolic DNA from dying cells have been shown to aberrantly trigger the cGAS-STING Pathway and IFN responses during conditions like systemic lupus erythematosus or Aicardi-Goutières syndrome. Figuring out ways to modulate cGAS-STING activation or signaling may yield new therapeutic approaches for these diseases.

Pharmaceutical Applications

Given its crucial contribution to antiviral immunity and cancer immunosurveillance, the cGAS-STING Pathway represents an attractive target for pharmaceutical intervention. Small molecule drugs that activate cGAS or STING are being developed as potential antiviral and anticancer agents. STING agonists administered alone or in combination with checkpoint inhibition immunotherapy show promise in treating solid tumors in clinical trials.

Moreover, cGAS or STING inhibitors may offer new ways to treat autoinflammatory conditions caused by overactive cGAS-STING signaling. Researchers continue working to refine drugs that can selectively modulate different points along the pathway for optimal therapeutic benefit while avoiding side effects. As understanding of this defense mechanism deepens, more opportunities may arise to harness it against an array of diseases with immunological underpinnings.

The cGAS-STING Pathway serves as a critical surveillance system helping our innate immune defenses detect cytosolic DNA. Its ability to sense microbial as well as aberrant self-DNA makes it an important regulator of antiviral immunity, tumor suppression, and inflammatory balance. Ongoing investigations into modulating cGAS-STING activation hold promise for developing new immunotherapies targeting infections, cancer, and autoimmune disorders.

Get more insights on this topic:   https://www.ukwebwire.com/role-of-cgas-sting-pathway-in-detecting-cytosolic-dna/

Author Bio:

Alice Mutum is a seasoned senior content editor at Coherent  Insights, leveraging extensive expertise gained from her previous role as a content writer. With seven years in content development, Alice masterfully employs SEO best practices and cutting-edge digital ing strategies to craft high-ranking, impactful content. As an editor, she meticulously ensures flawless grammar and punctuation, precise data accuracy, and perfect alignment with audience needs in every research report. Alice's dedication to excellence and her strategic approach to content make her an invaluable asset in the world of  insights. (LinkedIn: www.linkedin.com/in/alice-mutum-3b247b137 )

*Note: 1. Source: Coherent  Insights, Public sources, Desk research 2. We have leveraged AI tools to mine information and compile it

[anmapvnn]

GLUKAFERON

Interferon

[organichealthsolutions]

How Do Supplements Lead to Anti-Aging?

Millions of men and women aim to slow down the signs of aging while achieving a more youthful, radiant look. While skincare products, particularly serums, can help you achieve that, many seek approaches that lead to improvements from the inside out.

Anti-aging supplements are becoming more popular than ever. These products promote results from a cellular level. But how do they work?

What are Anti-Aging Supplements?

Supplements that fall under the anti-aging category aim to slow down the signs of aging. Depending on their formulation, that could mean promoting more refreshed and youthful skin. However, many products can also translate to better health and vitality.

Whatever the case, they work from the inside out. While traditional anti-aging skincare products are topical, these supplements are oral. That means you consume them much like your daily multivitamin!

Anti-aging supplements can come in gummy, tablet, capsule or liquid form. Whether you get a selenium supplement that protects from sun exposure or an anti aging polyphenols supplement formulated to provide multiple benefits, the main difference is that you consume these supplements.

How Do Anti-Aging Supplements Work?

The magic comes from the ingredients. These products contain ingredients that improve your skin and slow down the signs of aging at a cellular level. While your diet and supplement regime greatly keep you healthy, these supplements focus on keeping your cells young to deliver anti-aging benefits and more vitality.

Anti aging polyphenols supplement products are some of the best because they contain powerful plant compounds. Polyphenols are compounds that keep plants safe from ultraviolet radiation and oxidative stress. Studies are showing that humans can reap the same benefits and more.

Researchers found that polyphenols are effective in providing many anti-aging properties. They're potent antioxidants that neutralize damaging free radicals while protecting cells from oxidative stress. That protects your DNA from damage.

Polyphenols are also robust anti-inflammatories that tame inflammatory responses. Research suggests they also have anticancer properties.

Overall, polyphenols are the ingredient to success in the fight against aging. While aging is natural, supplements can make a difference by reducing the effects aging has on your appearance and vitality.

Read a similar article about supplement for artery protection here at this page.

[medicomunicare]

All hands on DECs: lift your skin up 'cause immunity won't TLR8 further X-age-rated IFNrence

Scleroderma or systemic sclerosis (SYS) affects approximately 300,000 people in the U.S., with about one-third developing systemic disease, which can affect major organs such as the lungs, kidneys or heart. Women are four times more likely than men to be diagnosed with the disease, but until now, the underlying reason for this gender disparity had remained elusive. Two new studies led by…

[academiavet]

Efeitos terapêuticos do interferon ômega felino (rFeIFN-ω) na evolução clínica de gatos naturalmente infectados com imunodeficiência felina (FIV) e vírus da leucemia felina (FeLV)

O rFeIFN-ω mostrou-se útil na melhora da sintomatologia clínica e no controle de infecções virais secundárias em gatos FIV+, FeLV+ e FIV/FeLV+.

Referência:

Cravo, J.A.P. (2011). Efeito do tratamento por interferão ómega de origem felina (rFeIFN-Ω) na evolução clínica de gatos naturalmente infectados com os vírus da imunodeficiência (FIV) e leucemia felinas (FeLV) e na excreção de vírus respiratórios concomitantes. Dissertação de Mestrado. Universidade Técnica de Lisboa, Faculdade de Medicina Veterinária, Lisboa.

[pwrn51]

How one Woman became a Trailblazer for Cancer

  Betsy’s guest is Judith L. Pearson, an award-winning author, and writer, who’s here to discuss her latest book, “CRUSADE TO HEAL AMERICA: The Remarkable Life of Mary Lasker.” In our conversation, Judy highlights the incredible story of Mary Lasker, a health activist and philanthropist, known for her passionate stance, “I am opposed to heart disease and cancer the way one is opposed to…

[pandemic-info]

Long COVID Looks Like Acute Infection in the Brain | Psychology Today

Key points:

Long COVID patients with brain fog have the biological signature of an acute infection in the brain.

50 percent of people with cognitive impairment from Long COVID improve after two years, but very slowly.

An effective interferon lambda response in the brain helps recovery from Long COVID cognitive impairment.

Researchers call for a clinical trial on the use of interferon lambda to treat Long COVID brain fog.