#monoclonal

[willowreader]

This is good news!

[bio-basic-inc]

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[petnews2day]

Monoclonal Antibodies Maintain Stem Cells in Mouse Brains

New Post has been published on https://petnews2day.com/pet-news/small-pet-news/monoclonal-antibodies-maintain-stem-cells-in-mouse-brains/?utm_source=TR&utm_medium=Tumblr+%230&utm_campaign=social

Monoclonal Antibodies Maintain Stem Cells in Mouse Brains

Summary: Utilizing monoclonal antibodies rather of standard immunosuppressant drugs protects stem cells in mouse brains. Source: University of Michigan A brand-new technique to stem cell treatment that utilizes antibodies rather of standard immunosuppressant drugs robustly protects cells in mouse brains and has possible to fast-track trials in people, a Michigan Medication research study recommends. For […]

See full article at https://petnews2day.com/pet-news/small-pet-news/monoclonal-antibodies-maintain-stem-cells-in-mouse-brains/?utm_source=TR&utm_medium=Tumblr+%230&utm_campaign=social #SmallPetsNews

[drferox]

Monoclonal Antibodies

So I listened to a talk from a drug rep the other day who came into the clinic to promote Cytopoint, the anti-allergy injection for dogs.

It’s a great drug, overall. Super useful for many, literally life changing for a few, and now a mainstay of the allergy treatments we offer. But I had to laugh at something the rep said:

“It’s not really a drug. It’s a bio-mimicry molecule! It’s replicating normal molecules that would be found in the body and just providing more of them!”

And I’m sitting here thinking: that is still totally a drug. A drug is any substance which when given to a living organism produces a physiological effect. 10mg of lokivetmab is most definitely a drug.

But if you are going to argue that Cytopoint is not a drug because it mimics a natural molecule found in the body, then by that logic neither are insulin, thyroxine, cortisone or just about every single hormone.

For goodness sake. I have to wonder what planet marketers live on some days.

We also had a bit of a debate because we’re widely told that Cytopoint shouldn’t have any side effects. Partly this is because monoclonal antibodies aren’t well known in veterinary medicine and they haven’t been around that long.

They’re certainly much safer than the equivalent drugs in other classes, but they’re not ‘side effect free’. They’re a protein, so it’s theoretically possible to be allergic to it. Like the Kesimpta I take it seems likely that some dogs will be ‘off colour’ for a day or so. The most common side effect is being quiet the next say, so it is pretty mild for a typical dog and still worth it. But it’s not zero.

Having a headache for a day is much milder than having acute kidney failure, but I wonder if we’ll get more reports in the future of extremely sporadic weird side effects as we gain more experience with this class of medication.

Medical advancements are wonderful and exciting. But don’t let marketers do all the talking!

And remember to report side effects to the manufacturer.

[cheatachu-72]

Biology was amazing actually

[equalistmako]

why is acetaminophen bad? genuine question

It’s not bad, per se.

But for a drug that’s easily available for purchase by anyone, it has a relatively low therapeutic index (i.e. the window of safety between a drug’s minimum effective dose & its fatal dose).

If you’re using it appropriately, it’s totally fine! But many people do NOT use this drug appropriately (as demonstrated by the amount of liver failure cases attributed to Tylenol/Acetaminophen worldwide), which is why I’m baffled it’s still available OTC.

My pharmacology professor strongly believed that, had Acetaminophen been created in the last decade with our current FDA regulations, it would’ve never seen the light of day.

I’ve also seen and heard of one too many cases of pets dying from consuming Acetaminophen, and it’s left a bad taste in my mouth for OTC pain relievers and NSAIDs in general.

[lachatalovematcha]

. ˚◞♡   ˚◞♡   ⃗ *ೃ༄. ˚◞♡   ⃗ ˚◞♡   ⃗ . ˚◞♡   ˚◞♡   ⃗ . ˚◞♡  

[ihugmomo]

my blorbos‼️‼️ (2/?)

Hanabie. :: Hettsu

☆ bassist girlie‼️ i love her sm she's adorable 💙🥺

misolade-edison :: Yagami Pet

☆ another underrated band. she's just like me fr

mercuro :: Suijou Neir

☆ bah bah bah‼️‼️ pretty girl pretty girl <33

MONOCLONE :: Kuromi Rara

☆ ourple princess <33 the personification of kuromi from sanrio frfr

Twinpale :: Shirayuki Himeno

☆ queen‼️‼️

[eosinophil-hate-blog]

[ladymacbethisagirlboss]

Nearly 5 weeks until my first written GCSE. Where did this year go. Seriously. I want it back

[nerdylizj]

procrastination is a beautiful thing.. that’s why it starts with pro.. Hope this clears some things up

[lilacthebooklover]

i wanted to revise but youtube said no :(

[drferox]

The ✨Joys✨ of Kesimpta

(With a medium amount of sarcasm).

Kesimpta is a monoclonal antibody named Ofatumumab which targets the B cells of my immune system to discourage them from demyelinating my spine and brain. It’s a very targeted therapy, these artificial antibodies only target one protein, and yet the side effect profile continues to be an interesting and unpredictable experience.

But firstly: does it work? Yeah, pretty well so far. Minimal progression, actually some improvement across most symptoms, and I will willingly trade the one day a month or so of side effects I have to endure for the medication that will hopefully keep me functional as long as possible. I will probably never go back to performing surgery, and there are bad days here and there, but the burning arm pain doesn’t happen anymore and the numbness is generally restricted to just hands, not the whole limb.

The side effects though, they have been… interesting. They’ve certainly lessened over time as I adjust to the medication, but it’s such a random grab bag of effects.

You get warned when you start this medication that it will cause a bit of a headache, so to take some Panadol. But what happened for me:

First two hours after the injection - nothing happened at all

Then the migraine came, plus heavy fatigue.

Then the shivering started, I had chills so bad that I was filling hot water bottles with boiling water to hug in my bed, because it was the only way I wouldn’t tremble constantly.

Then came the gastro signs, while I still had the chills.

Unrelenting insomnia approximately 12 hours after the dose.

The chills dissipated overnight but the nausea continued the next day, plus dizziness and exhaustion.

And I got to do that once a week for the first few doses, so I was pretty much non functional other than keeping myself alive at that point.

Over time, the side effects have been steadily less and less though. If I’m a little bit unwell in some way before a dose, the Kesimpta will exaggerate the symptoms, and I try and time the dose so I can sleep through most of the nausea and headache. I’m usually a bit off balance for most of the day, not enough to be a fall risk but aware enough that I am not right enough to drive and definitely shouldn’t climb a ladder.

But I still get these completely bizarre mood swings. I can go from being okay to crying over a sad thought in about 20 minutes, over no meaningful stimulus. I’m watching myself react this way and just have to ride it out, but there’s no way I could go to work on a medication day. People will think I’m insane or on a recreational drug.

So I have to take the day as a scheduled maintenance day.

Being on this medication has made me very glad for the Medicare system we have in Australia, and the pharmaceutical benefits scheme which subsidises the cost of a lot of medications through the government.

Without these systems, Kesimpta would be costing me about $2.5k per month. As it is now, it costs me about $60 a month, delivered, and I get a handy little ap that reminds me when my dose is due, and will send me an email or text message if it thinks I’ve missed a dose, steadily getting more frequent so that I will get a text message every hour as a reminder if it thinks I’ve forgotten.

[cbccindia]

Understanding Immunotherapy for Autoimmune Diseases

Introduction

Immunotherapy, a groundbreaking approach primarily recognized for cancer therapy immunotherapy, is now making significant strides in treating autoimmune diseases. This article delves into how immunotherapy is applied beyond cancer immunology immunotherapy to manage and treat autoimmune conditions.

The Mechanism of Immunotherapy in Autoimmune Diseases

Immunotherapy works by modulating the immune system, enhancing its ability to fight diseases. Unlike in immunotherapy cancer treatment, where the goal is to target and destroy cancer cells, in autoimmune diseases, the therapy aims to recalibrate the immune system to stop attacking the body's tissues.

Types of Immunotherapy for Autoimmune Diseases

There are various types of immunotherapy used to treat autoimmune diseases. These include monoclonal antibodies, cytokine inhibitors, and immune checkpoint inhibitors, each designed to alter specific immune system pathways. While some of these therapies overlap with those used in cancer treatment, their application in autoimmune diseases focuses on immune regulation and suppression of overactive immune responses.

Immunotherapy Medications and Treatments

Immunotherapy medications for autoimmune diseases are tailored to reduce inflammation and curb the immune system's erroneous attacks on healthy cells. The precise medication or combination of therapies depends on the specific autoimmune condition being treated, highlighting the personalized nature of immunotherapy.

The Role of Immunotherapy and Vaccines

Exploring the intersection of immunotherapy and vaccines reveals potential for preventative strategies in autoimmune diseases. Vaccines designed to induce tolerance in the immune system are under research, potentially preventing autoimmune diseases from developing or worsening.

Managing Side Effects and Costs

While immunotherapy offers new hope, it's crucial to consider immunotherapy side effects and immunotherapy cost. Side effects vary widely, from mild to severe, and must be carefully managed under medical supervision. The cost can also be significant, necessitating a discussion about healthcare resources and insurance coverage.

Conclusion

Immunotherapy for autoimmune diseases represents a promising frontier in medical treatment, offering hope for millions suffering from these conditions. As research progresses, it could redefine the therapeutic landscape for autoimmune diseases, much like it has for cancer.

Discovering Excellence in Cancer and Autoimmune Disease Treatment at CBCC India

At the forefront of medical innovation and care, CBCC India stands as one of the leading Cancer Hospital in India, dedicated to eliminating cancer and advancing treatment for autoimmune diseases. Our commitment to innovative research and exceptional care ensures that every patient receives personalized, state-of-the-art treatment. Discover the pinnacle of healthcare excellence at CBCC India, where we strive to conquer cancer and improve the lives of those with autoimmune diseases through cutting-edge immunotherapy and comprehensive care.

[chronicmigrainetime]

One year on Ajovy update!:

I can’t believe it’s been a year already, it’s gone so fast. I stopped doing monthly updates because the situation hasn’t really changed since the effect of the medication stabilised. I currently get ~10/30 migraine days a month —down from 30/30 before the medication— and my quality of life has improved dramatically as a result.

(Finding medication to help my POTS has also had a huge positive impact)

I’m still not really able to work a job, but I have been able to do a lot more of the work of being a person.

I had a review with the headache clinic that’s prescribing the Ajovy for me and they decided I can continue on it for another year (with another review at the end of the year), which is really good news.