#eosinophilic disease

[eosinophil-hate-blog]

[degenderates]

my tissue is scarring and becoming unusable as we speak, i want to kill myself

i want to live despite my immune system's attempt to kill me

my immune system is trying its best to protect me despite being sorely misguided. it has been traumatized by the toxins that living in the 21st century has put into my body and is reacting the only way it knows how. i have empathy for it and often feel the same visceral, overprotective reactions in reaction to violence and poison directed at those whom i love. i understand it. so i will work with it even if that means sacrifice, and i will live.

[tailsfromthecrypt]

[commonknits]

Hey I’ve just been diagnosed with two different autoimmune diseases, hypothyroidism and e.o.e., so now on top of my severe egg allergy I have to cut out a ton of other foods. So if anyone has any recipes or ideas for quick snacks I’d appreciate it. I’m down to really only eating ground beef, chicken, veggies, and fruit.

[chronicbeans]

Happy Chronic Disease Month!

According to the Chronic Disease Coalition, July is Chronic Disease Month! July 10 is also National Chronic Disease Day! I know not everyone celebrates it, but it is something meaningful to me because I got that chronic illness swag in my life. Lol

Basically, it's just a month for education on chronic diseases... Which I am VERY passionate about! I probably won't post that much about it, but I just wanted to make a post announcing it in case anybody else wants to celebrate it for whatever reason. OwO

I am not sure if Chronic Disease Month is considered an "official" thing, or just something the Chronic Disease Coalition does, but I will take any excuse to feel seen and appreciated, lol. Plus I missed Eosinophilic Awareness Week this year, so I gotta make it up to myself!

Anyways, I hope y'all are doing well! I know just checking in on someone can brighten their day, so check in on someone you care for today! It can really help out!

[chicago-geniza]

Finally did my Xolair shots a week late and can suddenly think and write again and were you aware: being in low-grade anaphylaxis all the time makes you stupid and near-comatose with exhaustion. I ate a chicken salad wrap yesterday where the wrap was one of those spinach whole wheat things and my joints and bones unionized and went on strike and then my face broke out in a rash and then I fell asleep sitting up outside in the middle of distro for like 5 minutes wearing two coats when it was almost 70 degrees ddsklfjdlfjsf. Woke up, took Midol, decongestants, and antihistamines, but oh my GD, I literally just took the fucking biologic that binds to my igE and goes “stop doing that” like it’s Osmosis Jones and my brain stops feeling like it’s padded with cotton balls and I stop feeling like I’ve drunk a deep draught of Bone Hurting Juice. Why do we have that lever. I can’t believe mast cell disease is real

[a-nihilistic-lime]

Have you struggled with eosinophilic esophagitis?

The fear of not having a direct allergic reaction?

The fear of feeling your throat closing? And being unable to swallow?

The fear of having something stuck in your esophagus?

I first got it in 2021, and I still don’t know what is the cause, not closer than I was two years ago. I tried PPIs, Flovent, Jorveza and the only one I can’t is Dupixent because when I took it for eczema back in 2019 it gave me the worst eye side effects that my doctor told me to stop it completely. Funny thing, it’s the only medicine that could potentially help with both of my autoimmune diseases!

Six food elimination helped, but I can’t live a life without these 6 major foods, I really hope it’s soy and not dairy. I’m starting my first single elimination with Dairy and testing soon.

If you live in Europe, Africa or the Middle East, and have EoE please tell me what is your allergen if you found it? I suspect wheat and dairy are majority only in the US.

[transorzesolutionstvm]

WHO has classified Eosinophilic cellulitis under the ICD-10 code L98.3 which falls in the range - Diseases of the skin and subcutaneous tissue

For More Details : 🌐 www.transorze.com ☎ +919495833319

[transorzekochi]

WHO has classified Eosinophilic cellulitis under the ICD-10 code L98.3 which falls in the range - Diseases of the skin and subcutaneous tissue

For More Details : 🌐 www.transorze.com ☎ +919495833319

[drpedi07]

Eosinophilic Gastrointestinal Disease

According to the localization of the gastrointestinal tract, primary eosinophilic gastrointestinal diseases include five variants such as esophagitis, gastritis, gastroenteritis, enteritis, and colitis.

[eosinophil-hate-blog]

[does-truth-matter]

The CDC has quietly changed who should AVOID the MMR vaccine.

https://www.cdc.gov/vaccines/vpd/mmr/public/index.html

They now state that ANYONE that “Has a parent, brother or sister with a history of immune system problems” should AVOID THE MMR VACCINE!

What exactly is an 'immune system problem?" Every autoimmune disorder.

* Achalasia

* Addison’s disease

* Adult Still's disease

* Agammaglobulinemia

* Alopecia areata

* Amyloidosis

* Amyotrophic lateral sclerosis (Lou Gehrigs)

* Ankylosing spondylitis

* Anti-GBM/Anti-TBM nephritis

* Antiphospholipid syndrome

* Autoimmune angioedema

* Autoimmune dysautonomia

* Autoimmune encephalomyelitis

* Autoimmune hepatitis

* Autoimmune inner ear disease (AIED)

* Autoimmune myocarditis

* Autoimmune oophoritis

* Autoimmune orchitis

* Autoimmune pancreatitis

* Autoimmune retinopathy

* Autoimmune urticaria

* Axonal & neuronal neuropathy (AMAN)

* Baló disease

* Behcet’s disease

* Benign mucosal pemphigoid

* Bullous pemphigoid

* Castleman disease (CD)

* Celiac disease

* Chagas disease

* Chronic inflammatory demyelinating polyneuropathy (CIDP)

* Chronic recurrent multifocal osteomyelitis (CRMO)

* Churg-Strauss Syndrome (CSS) or Eosinophilic Granulomatosis (EGPA)

* Cicatricial pemphigoid

* Cogan’s syndrome

* Cold agglutinin disease

* Congenital heart block

* Coxsackie myocarditis

* CREST syndrome

* Crohn’s disease

* Dermatitis herpetiformis

* Dermatomyositis

* Devic’s disease (neuromyelitis optica)

* Discoid lupus

* Dressler’s syndrome

* Endometriosis

* Eosinophilic esophagitis (EoE)

* Eosinophilic fasciitis

* Erythema nodosum

* Essential mixed cryoglobulinemia

* Evans syndrome

* Fibromyalgia

* Fibrosing alveolitis

* Giant cell arteritis (temporal arteritis)

* Giant cell myocarditis

* Glomerulonephritis

* Goodpasture’s syndrome

* Granulomatosis with Polyangiitis

* Graves’ disease

* Guillain-Barre syndrome

* Hashimoto’s thyroiditis

* Hemolytic anemia

* Henoch-Schonlein purpura (HSP)

* Herpes gestationis or pemphigoid gestationis (PG)

* Hidradenitis Suppurativa (HS) (Acne Inversa)

* Hypogammalglobulinemia

* IgA Nephropathy

* IgG4-related sclerosing disease

* Immune thrombocytopenic purpura (ITP)

* Inclusion body myositis (IBM)

* Interstitial cystitis (IC)

* Juvenile arthritis

* Juvenile diabetes (Type 1 diabetes)

* Juvenile myositis (JM)

* Kawasaki disease

* Lambert-Eaton syndrome

* Leukocytoclastic vasculitis

* Lichen planus

* Lichen sclerosus

* Ligneous conjunctivitis

* Linear IgA disease (LAD)

* Lupus

* Lyme disease chronic

* Meniere’s disease

* Microscopic polyangiitis (MPA)

* Mixed connective tissue disease (MCTD)

* Mooren’s ulcer

* Mucha-Habermann disease

* Multifocal Motor Neuropathy (MMN) or MMNCB

* Multiple sclerosis

* Myasthenia gravis

* Myositis

* Narcolepsy

* Neonatal Lupus

* Neuromyelitis optica

* Neutropenia

* Ocular cicatricial pemphigoid

* Optic neuritis

* Palindromic rheumatism (PR)

* PANDAS

* Parkinson's disease

* Paraneoplastic cerebellar degeneration (PCD)

* Paroxysmal nocturnal hemoglobinuria (PNH)

* Parry Romberg syndrome

* Pars planitis (peripheral uveitis)

* Parsonage-Turner syndrome

* Pemphigus

* Peripheral neuropathy

* Perivenous encephalomyelitis

* Pernicious anemia (PA)

* POEMS syndrome

* Polyarteritis nodosa

* Polyglandular syndromes type I, II, III

* Polymyalgia rheumatica

* Polymyositis

* Postmyocardial infarction syndrome

* Postpericardiotomy syndrome

* Primary biliary cirrhosis

* Primary sclerosing cholangitis

* Progesterone dermatitis

* Psoriasis

* Psoriatic arthritis

* Pure red cell aplasia (PRCA)

* Pyoderma gangrenosum

* Raynaud’s phenomenon

* Reactive Arthritis

* Reflex sympathetic dystrophy

* Relapsing polychondritis

* Restless legs syndrome (RLS)

* Retroperitoneal fibrosis

* Rheumatic fever

* Rheumatoid arthritis

* Sarcoidosis

* Schmidt syndrome

* Scleritis

* Scleroderma

* Sjögren’s syndrome

* Sperm & testicular autoimmunity

* Stiff person syndrome (SPS)

* Subacute bacterial endocarditis (SBE)

* Susac’s syndrome

* Sympathetic ophthalmia (SO)

* Takayasu’s arteritis

* Temporal arteritis/Giant cell arteritis

* Thrombocytopenic purpura (TTP)

* Tolosa-Hunt syndrome (THS)

* Transverse myelitis

* Type 1 diabetes

* Ulcerative colitis (UC)

* Undifferentiated connective tissue disease (UCTD)

* Uveitis

* Vasculitis

* Vitiligo

* Vogt-Koyanagi-Harada Disease

Wonder how many doctors are paying attention?

~shared from Jodi Wilson

[read-watch-sleep]

I am being so silly in your inbox (+ Discord) I have managed to convert you to the ScarVi verse and Im cackling like an evil villian about it

Well, my dear Kai, you're not the only one with the capacity for evil. (It is a delight to hear from you always). I'm using your ask as an opportunity to spread propaganda featuring my Pokémon conspiracy theory about a game I've never played (I only play pkmn Emerald on an emulator and Diamond on my jalbroken 3DS). You already know about this, of course. But I digress,

^ This Guy Is a Reference to the Toxic Oil Syndrome Outbreak of 1981 

(gifs by @/ianime0 and rant under the cut)

His name in the Japanese game is Colza, and in the English translation is Brassius, both names for the plant known as Rapeseed, and the plant that makes Canola Oil. We also know that he looks sickly, and at one point, he was deathly ill with something unknown, which is part of what inspired his work Surrendering Sunflora.

In the 80s, canola/colza oil was illegal to sell for cooking in Spain (mostly for economic reasons) and had to be denatured for industrial use to be imported in as lubricant or biodiesel.

Now, in 1981, some 20,000+ people developed a strange musculoskeletal disease, that resulted in pulmonary edema (fluid in the lungs), muscle pain and failure, fever, and eosinophilia (too many eosinophil white blood cells), scleroderma (autoimmune rash) ect. The progression was brutal. Patients would go from a cough and a fever to strange rashes and rapidly losing weight, to having their muscles seize permanently and lifelong hepatitis. Thousands of people were permanently disabled, and more than 400 people died.

The cause?

Colza/Rapeseed oil, having been denatured with the chemical aniline, then filtered and mixed with olive oil to sell as edible cooking oil (which wasn't at all safe to eat).

It's just a bit of a coincidence that one of the few canonically ill characters in the Pokémon universe just happens to be named after a plant that caused an epidemic in the place where he's meant to be from, especially when he always battles with Pokémon from the Arboliva line.

So yeah, my theory is that he's got Toxic Oil Syndrome.

[dailyunsolvedmysteries]

A Boy Ate A Slug On A Dare And Ended Up Paralyzed

In 2010, 19-year-old Sam Ballard and his friends were indulging in a casual night of wine drinking on a back patio in Sydney, Australia, when the group came up with a seemingly harmless idea. As a slug inched its way across the concrete, Ballard asked his friends if he should eat it. When his pals didn't question the idea, he tossed the slug into his mouth and swallowed.

Soon after, Ballard began experiencing strange symptoms. When he complained that he felt intense leg pain, Ballard's mother feared he might be developing multiple sclerosis. Doctors uncovered the real culprit as his symptoms progressed - Ballard had ingested a slug carrying rat lungworm disease.

This parasitic worm settles into the lungs of rats before eventually being discharged through their feces. When a slug, freshwater crab, shrimp, or frog comes in contact with the feces, it then contracts the parasite itself.

Unfortunately, the worm doesn't move through the human digestive tract in the same manner that it does a rat's. Instead, the parasite can be lost in the body, eventually lodging itself in the brain. Soon, the unwanted organism causes inflammation of the membranes surrounding the brain and spinal cord, called eosinophilic meningitis.

Though most recorded cases have mild consequences, some, like Ballard's, end with devastating results. Ballard fell into a 420-day coma shortly after the diagnosis. When he awoke, he was completely paralyzed and forced to eat through the use of a feeding tube. He eventually perished due to his injuries.

[flyonthewallmedstudent]

Helicobacter Pylori

Spicing things up a bit with a Gram Negative Helical/spiral Bacteria

Epidemio:

up to 50% of the population worldwide, but even more in endemic countries/the 3rd world

it can cloud differentials, as it can be asymptomatic unless it caues peptic ulcer disease, in which case the infection may have been decades prior to detection - so you have to interpret serology with a grain of salt (it may not be the culprit of acute infection)

often picked up in early childhood and lingers without treatment for dcades

by contrast, 5% of children in the US have had it, so it may change your clinical decision making depending on where your patient grew up

In australian populations, up to 30% have it, but again, high frequency in older migrants, lower socioeconomic status etc.

Transmission:

faecal oral or even sexual (did not know that one)

increased risk:

lower socioeconomic status/growing up in a developed country

family history of infection and gastric cancer

What it does:

cause ulceration (peptic ulcer disease)

and inflammation or gastritis

due to it's helical shape and flagella, it can penetrate the mucosal lining

Trivia/History:

discovered by Australians in Western Australia in the 1980s

To quote the IM physician, Barry Marshall, in the face of skepticism that a bacteria could survive the stomach's acidic environment: "everyone was against me, but I knew I was right"

After failing to publish and some lab snaffus, he decided to do a Jonas Salk and swallow a broth of Hpylori himself. Of course this last experiment was published in an Australian journal.

At any rate, it is now widely accepted that Hpylori is linked to PUD and gastric cancer and by 2005, the two Australians who found the bacteria received the Nobel prize in medicine

we now know so much more about the pathogen with advancements in microbiology

they also came up with the urease breath test for it

Clinical presentation:

asymptoamtic

symptom onset occurs after gastritis and peptic ulcer disease develop: nausea, vomiting, dyspepsia, abdo pain, or at the extreme when the lining has eroded, bleeding/haematemesis

IMage source

Important differentials

coeliac's

Crohn's

nSAID induced gastritis

reflux

lactose intolerance

eosinophilic oesophagitis (sooo rare, usually a/w dysphagia)

Investigations (all with relatively good/high sens and spec)

H pylori antigens in stool

serology (antibodies in serum, urine) --> usually IgG, hence can remain positive for years even post eradication

urease breath test

if a scope was involved due to PUD, then histopathology and culture (reduced sensitivity if treated with PPI in 2/52 prior or Abx 4/52 prior)

actually had no idea they breathed into little bags.

Treatment:

triple therapy - PPI, amoxicillin and clarithromycin for 14 days, in penicillin allergy replace amox with metro (increasing resistance is why metro is not first line in some countries - refer to local guidelines made based on local Abx resistance trends)

In patients younger than 50, it can be cost effective to treat if they have reflux on testing (if there's a high pretest probability - see increased risk groups) given the life time risk of PUD & gastric cancer, can also reduce risk of GIB

balance of risk/benefit: will it significantly improve QOL or will risks of ADRs outweigh the benefits (eg frail, elderly, multiple comorbidities)

when used in those with PUD - improves ulcer healing, recovery and prevents relapse

in simple ulcers, triple therapy is all that is required in more chronic complex ones --> 8/52 of PPI is also recommended to prevent recurring of bleeding etc.

not treating can lead to relapse and complications like bleeding/perforation/cancer risk

Complications

rarely, it can cause gastric adenocarcinoma as a known carcinogen

aka MALT lymphoma - mucosa-associated lymphoid tissue

this resolves with triple therapy (Usually)

consider it in family histories of gastric cancer

life time risk of gastric cancer at 2% and 15-20% risk of peptic ulcer disease

Wish the acronym wasn't MALT. But could be a good way to remember it. MALT, tasty, gastritis and Hpylori.

Follow-up

test for eradication 2 weeks post with stool antigen or urease breath test (serology less effective as the IgGs can remain positive for years) but that's on holding the PPI for 1/52 to prevent a false negative, some countries want both tests

in resistance or relapse there's salvage therapy, usually with bismuth or a quinolone.

Sources:

Wikipaedia - I havent covered pathophysio or it's cellular mechanisms and virulence factors, but there's a good overview in wiki

StatPearls (more paeds focused in this one)

CDC guidelines

Australian Therapeutic guidelines (Paywalll rest above are free)

[allformrno]

Eosinophilic Esophagitis

I love myself but some days it’s hard living in my body. This disease that I have makes living really hard. As depressing as that sounds it’s not. There are so many ways to cope with what I have and having a positive attitude really helps. But it's hard when I try to explain it to others and those people will never seem to understand. They won't understand what it’s like to not be able to eat things other people can. Having a dietary restriction is a pain in the butt too. You end up eating the same thing in different variations multiple times. You end up getting sick and tired of it but there is nothing you can do about it. I tend to rather starve than eat sometimes because of the fear of getting it trapped inside my throat or not enjoying it the way I want to enjoy it. My options are limited and it sucks everything out of you when you aren’t able to choose outside of the three choices you get. Going to dinners with friends and family is my biggest fear. I hate when I’m faced with the words sorry you can't have this or sorry it contains traces of ingredients you cannot consume.

I have been told by peers, teachers and random people to just take the risk and that they are also ‘lactose’ or better yet ‘just peel it off’. But that's not how it works for me, as much as I would like to, I just can't risk it like that. Even though they may try to understand, it does not seem like they grasp the fact that mine is severe. That even those labels that may contain or was produced in a facility that also uses the product actually has the ingredient in it. With just one bite I can determine whether or not it truly has it. The constant fear of getting sick is something so scary that it makes me feel like I am solely responsible for having this sickness. Even though it is not something I can just decide to have. Its something I was born with.