#organoid intelligence

[stemgirlchic]

why neuroscience is cool

space & the brain are like the two final frontiers

we know just enough to know we know nothing

there are radically new theories all. the. time. and even just in my research assistant work i've been able to meet with, talk to, and work with the people making them

it's such a philosophical science

potential to do a lot of good in fighting neurological diseases

things like BCI (brain computer interface) and OI (organoid intelligence) are soooooo new and anyone's game - motivation to study hard and be successful so i can take back my field from elon musk

machine learning is going to rapidly increase neuroscience progress i promise you. we get so caught up in AI stealing jobs but yes please steal my job of manually analyzing fMRI scans please i would much prefer to work on the science PLUS computational simulations will soon >>> animal testing to make all drug testing safer and more ethical !! we love ethical AI <3

collab with...everyone under the sun - psychologists, philosophers, ethicists, physicists, molecular biologists, chemists, drug development, machine learning, traditional computing, business, history, education, literally try to name a field we don't work with

it's the brain eeeeee

[kenyatta]

Recent advances in human stem cell-derived brain organoids promise to replicate critical molecular and cellular aspects of learning and memory and possibly aspects of cognition in vitro. Coining the term “organoid intelligence” (OI) to encompass these developments, we present a collaborative program to implement the vision of a multidisciplinary field of OI. 

This aims to establish OI as a form of genuine biological computing that harnesses brain organoids using scientific and bioengineering advances in an ethically responsible manner. Standardized, 3D, myelinated brain organoids can now be produced with high cell density and enriched levels of glial cells and gene expression critical for learning. Integrated microfluidic perfusion systems can support scalable and durable culturing, and spatiotemporal chemical signaling. Novel 3D microelectrode arrays permit high-resolution spatiotemporal electrophysiological signaling and recording to explore the capacity of brain organoids to recapitulate the molecular mechanisms of learning and memory formation and, ultimately, their computational potential. Technologies that could enable novel biocomputing models via stimulus-response training and organoid-computer interfaces are in development. 

We envisage complex, networked interfaces whereby brain organoids are connected with real-world sensors and output devices, and ultimately with each other and with sensory organ organoids (e.g. retinal organoids), and are trained using biofeedback, big-data warehousing, and machine learning methods. In parallel, we emphasize an embedded ethics approach to analyze the ethical aspects raised by OI research in an iterative, collaborative manner involving all relevant stakeholders. 

The many possible applications of this research urge the strategic development of OI as a scientific discipline. We anticipate OI-based biocomputing systems to allow faster decision-making, continuous learning during tasks, and greater energy and data efficiency. Furthermore, the development of “intelligence-in-a-dish” could help elucidate the pathophysiology of devastating developmental and degenerative diseases (such as dementia), potentially aiding the identification of novel therapeutic approaches to address major global unmet needs.

Key points:

Biological computing (or biocomputing) could be faster, more efficient, and more powerful than silicon-based computing and AI, and only require a fraction of the energy.

‘Organoid intelligence’ (OI) describes an emerging multidisciplinary field working to develop biological computing using 3D cultures of human brain cells (brain organoids) and brain-machine interface technologies.

OI requires scaling up current brain organoids into complex, durable 3D structures enriched with cells and genes associated with learning, and connecting these to next-generation input and output devices and AI/machine learning systems.

OI requires new models, algorithms, and interface technologies to communicate with brain organoids, understand how they learn and compute, and process and store the massive amounts of data they will generate.

OI research could also improve our understanding of brain development, learning, and memory, potentially helping to find treatments for neurological disorders such as dementia.

Ensuring OI develops in an ethically and socially responsive manner requires an ‘embedded ethics’ approach where interdisciplinary and representative teams of ethicists, researchers, and members of the public identify, discuss, and analyze ethical issues and feed these back to inform future research and work.

[teledyn]

The presentations and discussion in this session build on the previously posted Frontiers in Science article ‘Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish’.

[thedepartmentofdiscoveries]

And so it begins......*ominous music*

[algoworks]

Unleashing the Power of Organoid Intelligence: Watch our captivating video as we delve into the fascinating world of AI-inspired by the complexity and efficiency of biological systems. 

Join us on a journey where innovation meets nature, unlocking new frontiers of intelligence. 🧠🌱

[innonurse]

A triage platform powered by AI could aid in the response to future virus outbreaks

- By InnoNurse Staff -

A team of academics from Yale University and other institutions across the world has created an innovative patient triage platform powered by artificial intelligence that the researchers claim is capable of predicting patient disease severity and hospitalization length during a viral outbreak.

Read more at Yale School of Medicine

///

Other recent news and insights

Robots have the potential to encourage healthy aging (Newcastle University)

A new study aims to avoid the formation of scar tissue surrounding medical devices (University of Galway)

Combining AI models increases risk assessment for breast cancer (Radiological Society of North America)

A 'mini-brain' investigates the relationship between concussion and Alzheimer's disease (Purdue University)

ConcertAI's TeraRecon now has a cardiology suite within its Eureka Clinical AI platform (ConcertAI/PRNewswire)

[iwonderwh0]

Bio-digital computers/life forms now officially exist

Do with this information whatever you want

Tagging you because you may find it interesting

@kamari2038 @detroitbecomeonline

Also, related vid:

[cbirt]

Scientists from Johns Hopkins University lay out the possibility of energy-efficient biocomputing using brain organoids (3D brain cell cultures) that surpass in-silico computing capabilities. The recent advances in how human stem cell-derived brain organoids replicate crucial cellular, and molecular aspects of learning and memory have led to the coining of the term Organoid Intelligence (OI). The development in brain organoid research promises to address in-vitro cognition or, as the authors say, intelligence-in-a-dish. The authors anticipate OI-based systems to yield faster decision-making capabilities, uninterrupted learning during tasks, and greater data and energy efficiency as compared to Artificial Intelligence-based systems. The research was recently published in Frontiers in Science.

Biological learning or Machine learning: which is more efficient?

Biological as well as machine learning involves building internal representations of the world to enhance task performance. But the implementation mechanisms involved in the two learning paradigms result in drastic efficiency differences.

Continue Reading

[alennia-becker101]

In The Amazing Digital Circus, Caine's name is an acronym, standing for Creative Artificial Intelligence Networking Entity. I also came up with my OC's name with an acronym.

Cody's name stands for Creative. Organoid. Data. Yield. (Yes, I know not as clever or clear has Caine's acronym, but I'd tried my best. It's hard finding words that fit but also starts with each letters.)

You guys seemed more interested in Cody's character card than his actual drawings.

[bpod-bpod]

Young at Brain

Ageing is inevitable and universal, but understanding the biological processes behind it might help ease the experience and prevent some unwanted conditions that so often come with age. Our immune system ages with our body, but what role this plays remains unclear because we lack good platforms to investigate the interaction between the immune system and our organs, particularly the brain, in the lab. So researchers have developed a human brain organoid – a 3D-printed structure on which brain cells and structures can grow and be observed (pictured, with mature (green) and starter (pink) brain cells called neurons). Immune cells from young and older donors were implanted on the organoid, and markers of ageing arose in brain cells exposed to older cells, suggesting the immune system actively drives some of the changes that occur in the brain as we age, and proving the potential of this platform for further experiments.

Written by Anthony Lewis

Image from work by Zheng Ao and colleagues

Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Advanced Science, July 2022

You can also follow BPoD on Instagram, Twitter and Facebook

[sciencespies]

A single gene mutation may have made us smarter than Neanderthals

https://sciencespies.com/humans/a-single-gene-mutation-may-have-made-us-smarter-than-neanderthals/

A single gene mutation may have made us smarter than Neanderthals

Modern humans have a gene mutation that boosts the growth of neurons in the brain neocortex, a brain region associated with higher intelligence

Humans 8 September 2022

By Michael Le Page

The differently shaped skulls of Homo sapiens (left) and Neanderthals (right) could relate to a mutation that changes the TKTL1 protein

PPS Copyright: PHILIPPE PSAILA/SCIENCE PHOTO LIBRARY

Modern humans have a mutation that boosts the growth of neurons in the neocortex, a brain region associated with higher intelligence. This is absent in more ancient humans like Neanderthals, so it is likely that it makes us cleverer, say the researchers who uncovered it.

“We can assume that it made us smarter,” says Anneline Pinson at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany.

“I would say so,” says her colleague Wieland Huttner. “But we cannot prove it.”

Advertisement

The mutation results in a single amino acid change in a protein called TKTL1. Previous studies have shown that this mutation is present in almost all people alive today, but not in more ancient humans, such as Neanderthals and Denisovans, or in other primates.

The TKTL1 protein is also known to be produced in the progenitor cells that give rise to the neocortex – the outer layer of the brain involved in conscious thought and language – suggesting that the mutation might have helped shape the brains of modern humans.

To find out what difference the mutation makes, Pinson, Huttner and their colleagues added the modern human TKTL1 protein to the brains of mouse and ferret embryos. They also grew brain organoids from human cells, some of which were gene edited to produce the older version of TKTL1.

These studies show that the mutation increases the number of neocortex progenitor cells, called basal radial glia, which results in a higher number of neurons in the neocortex. The result would have been an increase in the size of the neocortex, or of the density of neurons within it, or both, says Huttner.

Studies of skulls suggest that the brains of modern humans and Neanderthals were similar in size, but shaped differently, with Neanderthals having more elongated brains. The researchers speculate that it is possible this difference in shape is due to the mutation.

So could people be made more intelligent by tweaking genes in a way that further increases the number of basal radial glia?

“I don’t know if we could,” says Pinson. Having more neurons isn’t always a good thing, she says.

Journal reference: Science, DOI: 10.1126/science.abl6422

Sign up to Our Human Story, a free monthly newsletter on the revolution in archaeology and human evolution

More on these topics:

#Humans

[dragonfoxstardesigns]

Part Two: Head Over Heels

Continuation of Part One! Hope you’ve enjoyed the ride so far! Let me know if you’d like to see more of them via comments and be sure to like and reblog, thanks! This part is still SFW with NSFW following in Part Three!

As always, this isn’t for those under the age of 18! Minors and ageless blogs will be blocked! You’ve been warned!

Now back to our scheduled programming~

 It has been a few years since these two unlikely individuals met. A lot has happened since then. Besides growing up via separate paths of their own, they both also matured in their own ways from their occupations to their physique as well. Riley has became a successful mercenary in her own rights though she still believes not to take full credit as her fox organoid, Vulpes, also was her partner through every errand they had to partake in. Along with mercenary errands, she found herself having to train under military assistance considering her screw ups in the past were because of her clumsiness and albeit lacking in personal training of her own. Granted, Riley didn't have to join either the Empire or the Republic as she was a rebel in everything she got caught up in. Which is exactly how Riley ended up, on more than one occasion, bumping into the infamous Jack Hunter.

 Jack also grew up, and had to take on full responsibilities after his father's passing. The unknown organization that his father ran had been a lot to handle and so, as his birthright, he kept his identity a secret from public eyes. His work space being an office whereas his real works as an archaeologist were kept below common areas in secret workspaces deep beneath the building. However, despite his astounding growth in intelligence and physique, he had a hard time getting caught by a clever mercenary named Riley Foxx. Her and the fox organoid named Vulpes were always one step ahead of him and his plans. Even with discovering and reviving an organoid of his own, a wolf type named Wolfe, both could not keep from bumping into these two no matter how much they tried.

 It got to the tipping point of the iceberg where, eventually, Jack began to have feelings for Riley. At the start of both their journeys, their relationships were at best that of rivals. They'd compete either with themselves or their organoids, and it quickly evolved to having battle competitions with their own zoids - Riley with her Blade Liger 'Amber' version, and Jack Hunter with his Command Wolf RZ-009 'stealth ops'. However, through the battles and the paths that were crossed through the years, he became infatuated with her. Not only because of her beauty obviously, but also her endurance and remarkable piloting skills. Jack was impressed that he didn't come too often in his line of work. His leadership skills were the only things that helped his unknown organization continue to thrive and prosper. Even he had to keep his physical health afloat to keep up with both the common undercover work and of course while exploring the ruins of the ancient Zoidians.

 However, Jack wasn't the only one that had a crush on Riley. Many of Riley's crewmates and foes were wanting to find a way to get the best mercenary money could buy. To their dismay, Riley had no interest in being with anyone at the time. Her path was already laid out for her, and Riley was content in doing mercenary work and finding adventure wherever life threw her way. But, despite all of that, she did find it extremely difficult to concentrate every time she had accidentally bumped into Jack. So much so that, through the past few years, Riley too found a thrill of pleasure of sorts whenever bumping heads with her rival. It got to the point where they'd ended up being in awkward positions too. Her face flushed, as was his, whenever they met through the rare occurance of him somehow stumbling and falling onto her and vice versa when trouble brewed.

 "Hey! Get off of me!" Jack grumbled gaining consciousness after hitting his head against the ground. His body slack underneath Riley's, who too had passed out when the explosion caught them both.

 No response came from Riley though he could hear both Wolfe and Vulpes growling ahead. Whatever caused the unfortunate accident had made both organoids upset. Their heels hackled and ready to pounce at the opposing foes. However, oddly enough there didn't seem to be anything there. Least it seemed that way as Riley's rival sighed helping her off the ground.

 "Well, I guess it can't be helped. What should we do now...?" He pondered in thought, looking over to see the two organoids oddly not at odds with one another. Jack nodded to both Vulpes and Wolfe heading out of the ruins site with Riley in tow. It looked like they'd both have to tend to their wounds knowing that their fall was anything but a fluke. Unfortunately there wasn't anything the unknown organization's leader could do in regards to the culprit that had mysteriously vanished. Someone had oddly wanted what he had came for as well as knew that both the mercenary and himself were their targets. Guess he'd have to do some research after they get back to his place. That was the only solution Jack could come up with that wouldn't blow his cover. To be seen with a mercenary in the public eye would be embarrassing. That and the news crew would certainly love a juicy story that they'd likely twist in order for their own personal benefits. Either way, Jack didn't like the thought of bringing Riley to his own bedroom but it couldn't be helped with their current situation. He'd have to ask for his personal doctor/nurse to make sure Riley didn't have any internal injuries that couldn't be seen from the naked eye.

 Eventually though, with prestigious stealth, Jack made his way back to the hangar in his command wolf whereas Vulpes kept the blade liger hidden from the town's view just enough so that Riley couldn't be caught on any of the security cameras. It was risky, but Jack knew the best care would have to be at his own estate. He already had the doctor on the way so at least now he could get her safely to one of the guest rooms while tending to his own needs. If Riley woke up, Jack had to devise a clever plan. However, even he was at a loss for words, not sure where to even begin. Maybe he hit his head a little too hard on that fall was all the rival could think while barely functional to walk much less carry Riley from the hangar, up the staircase, and up to the guest room adjacent to his own. There he'd casually left her on the bed for the doctor to figure out what to do for her while going to the washroom to get cleaned up and check for any injuries that weren't visible. His uniform was already in tatters and would have to be mended.

 "Doctor, it's good to see you. I have her in the guest room. Make sure she's well taken care of and let me know if there's anything urgent. You have my regards." He addressed the doctor while slipping away to his own bedroom. The master suite has his own personal bathroom to soak and tend to any cuts or bruises. Goodness knows the rubble had his hair and clothes a mess. Dirt even on his scuffed boots. His red visor was broken too so it must have looked rather gruesome for the doctor to see his scarred face with his blind eye still intact. Vision impaired didn't really bother Jack much as he was well used to the stares and having to rely on his good eye to see when not wearing his red visor. The leader sighed, taking his mind off things, even for a moment, to clear his head and take a decent bath. His head throbbed, feeling a crust of dry blood. He may have to ask the doctor to come in and check to make sure his concussion wasn't severe.

 "Dr. Hunter, the woman is in bed asleep still. I tended to her wounds though it seems she only had a concussion. Cuts and bruises seem to not be severe, and there is no internal bleeding that I could find." The doctor stood at the door to his room waiting for Jack to respond. "I can leave if you are busy. Though I'd rather check to make sure you don't have any injuries either."

 Just then the door opened with Jack wearing a towel around his waist. "Thanks, Doctor. I can let you examine and see for yourself. I'm glad she's not severely injured and is safe." He concluded letting the doctor tend to his injuries which seemed to be akin to Riley's being unconscious. Jack was fortunate not to have been out for so long. That and able to carry a woman all the way back to his place from the ruin site.

 "So, who is this woman if I may ask? She seems to be a close friend of yours I'd taken?" The doctor hesitated to ask but wanted to know for sure why Jack would have brought someone he'd haven't seen before. It was unlikely that Jack would have brought anyone that wasn't family or acquaintance from his work.

 "She's a mercenary. I just happened to have bumped into her and gotten us both in a mess. If you have anything else then I think we're done here. I can have payment sent to you for all the trouble, but remember to leave our conversation private as agreed, understood?"

 "I see, and of course. Both of you have been cleared in good health and I prescribed some medication to help with soreness and headaches from concussions. If there are any problems that come up, please do call and I'll come right over. Everything is kept between us as promised." The doctor nodded briefly before heading out letting Jack have privacy to get dressed into a more suitable attire to greet his guest in the next room over. Hopefully it won't be much longer until Riley awakes. However, first Jack had to make sure they had dinner and to find out where Wolfe and Vulpes had gone off to. Most likely they were resting from saving their partners but if Riley wanted to see Vulpes he'd have to know where they are beforehand.

 "Ugh...my head..." Riley stirred finally from unconsciousness. "Where am I...?" She croaked feeling parched and sore all over. Her head was throbbing a little, but it seemed she was taken care of judging by the bandages and smell of ointment. Was she in a house or a hospital? She couldn't tell as everything around her was clean, but it didn't look like an ordinary hospital room. It was like she was in a palace or wealthy house of sorts judging by the size and furniture around the room.

 "You are well taken cared of in my very own home. I hope you like it here. I don't normally get visitors ya know?" Came a strikingly familiar voice nearby. Riley tried to sit up, but she felt support behind her. A pillow soon replaced a rough calloused hand. "You...your Jack Hunter, aren't you?" She turned, finally seeing the hero who rescued her though Riley thought she was dreaming. It couldn't have been him who had brought his own arch nemesis here...?

 "I am. Quite surprised, aren't you? Well let's just say you owe me big time for that commotion back there. I had to make sure we both got here alive after falling. You were lucky I cushioned your fall or else we'd have both been in worse off shape. And don't worry about the medicine and such. I had a private doctor look after you. You should be fine after a few days and can leave afterwards."

 Riley couldn't believe her eyes or what she was hearing. To think that of all the people that were on Planet Zi...Jack was the one that saved her life?! It didn't seem real. Almost too good to be true.

 "I...thank you. I suppose I do owe you now for saving my life and all. Though...wait where's Vulpes? What have you done with her?" Riley eyed him suspiciously knowing that her arch rival would have loved to get his hands on her fox organoid. After seeing him in the ancient ruins he had to be up to no good, right?

 "Relax. She's fine. Your fox organoid is with mine actually. Wolfe and Vulpes are resting in the hangar with our zoids. They've dealt with just as much trauma as we did." Jack replied, coming to sit down beside her bed.

 "She's okay...thank goodness. But...I didn't know you of all people had an organoid like mine? Since when did you steal one?"

 "I didn't steal one...not technically. I researched the very ancient ruins we first met and used my scientific discovery and archeological methods to revive the pod that held Wolfe. Unfortunately, I never did see a Zoidian with them though I assume he quite likes me seeing as how Wolfe never leaves my side. He's my companion as Vulpes is yours."

 "I see..." Riley nodded with a thoughtful hum resting her head back against the pillow. "Well...now that I know where I am, who rescued me, and where Vulpes is...can I ask you something?" She looked over to Jack, seeing him look at her earnestly.

 "Yeah...what is it you wanted to ask?" Jack raised an eyebrow curiously her way.

 "How long am I supposed to be in bed? Am I allowed to get up and move around freely here or am I not even allowed to do that...?" Riley eyed him but not in a cruel manner.

 At that, Jack laughed heartily. "Yes, you can move around as you please. You aren't held prisoner here or anything like that I can assure you. I was just about to get you to come down for dinner with me. That is..if you don't mind joining me?"

 Riley was kind of stunned by the way Jack sounded like he had proposed to her. Her cheeks flushed slightly at his words, but she nodded and slowly sat up more before moving the duvet off. She had on her clothes still thank goodness but nothing was broken. Just scrapes, cuts, and bruises here and there from what she could tell.

 "If you don't mind, then I'd love that. I'm starving...but I might need to get cleaned up first. You mind if I do that first before we have dinner. After all, I wouldn't want to make a mess of your place." She grinned bashfully up at him. Did she have any clothes here that should change into in the meantime?

 "I...well I wouldn't say no to that. You are free to use the guest bathroom. It's over yonder and of course clean as is the rest of the house. Clean clothes though...well I don't have much besides my own I'm afraid, but you are welcome to take what you can fit from the dresser and closets in here. Feel free to come downstairs when you are done." At that, Jack Hunter left to give Riley some privacy while he went downstairs to get the kitchen and dining room set up for her.

 A good thirty minutes or so, Riley came down the stairs after freshening up. She felt vulnerable only being able to find loose-fit clothing that was decent enough to throw on. A large shirt and shorts that must have been his at some point. The detergent definitely smelled like lavender just like the familiar scent of his uniform before she had gone unconscious back at the ruins. She hesitantly walked towards the smell of cooked food. Her stomach growled in confirmation as the sight of the kitchen and dining room made her mouth water. Though, the sight of Jack in casual wear also seemed to make her weak too. Riley couldn't remember the last time, if ever, seeing her arch rival outside of his uniform much less vulnerable just as she was. She swallowed thickly before going over to sit down as Jack fixed her a plate of what looked to be delectable foods of all sorts.

 "Wow...I...this is a lot of food! Are you sure this is for the two of us?" Riley asked, looking over to him as he sat next to her already digging in to his plate of delicious food.

 "Yeah...it's enough to make you not miss a meal. Hope that's decent for you to eat." Jack replied almost too casually for her this time. His demeanor seemed to have fallen since being in the house. Almost like he wanted to try to not scare his guest away. Comfortable even.

 Riley simply nodded and dug in, helping herself to all the amazing food there from fish, rice, and even delectable vegetables. It wasn't overly extravagant, but it's more than what she could usually make or afford on the go. Her stomach seemed to agree contently with all the food and the medicine for her concussion seemed to finally be working.

 "So...what's it like living in a place like this? I don't thoroughly believe you are just an archeologist seeing as how you can have your own private doctor and estate." She thought out loud wanting to know more about Jack and who he really is. After all, they were going to spend a few days together here so why not start getting to know him now?

 Jack nearly choked on his food at the question Riley had asked him. Already straight and forward as always. He sighed wiping his mouth with a napkin before getting up to walk towards the window looking out into the night sky. 

"Well...you are straight forward as always. You are right though. Archaeology is just one side of my life. Truth be told, I knew this day would come. Usually I would say it's confidential, but the truth is I run my father's business. Leadership is often full of responsibilities, Riley, and as such I take up on making sure I follow his legacy. However...I do not wish to go down the same path that my father took. I only run it for the money and personal reasons in order to get closer to pursuing my dream of finding something that is unlike anything I'd ever seen. Though truth be told I did find Wolfe that fateful day we met at the ancient zoidian ruins. However, I long to look for more than that. My heart yearns for something much more though I can't quite fathom what it is, or why. I just follow my instinct as I am sure you do as well, Riley. After all...we do seem to bump into each other a lot. Wouldn't you say it was fate that brought us together, hmm?"

 Riley watched as Jack Hunter explained everything to her. It was like something enlightened deep within herself. Of course, Vulpes had been her companion ever since she could remember. It did seem to be too good to be true that their paths continued to cross time after time again. And although he didn't tell her exactly everything like the name of the organization, Riley could at least understand from his point of view as to why and what his reason was for doing what was best in his circumstance. She sighed and nodded before getting up to stand beside Jack sharing the outlook from his estate. The night sky did look beautiful out here.

 "Yes. I can't say why or how or for what reason our paths have crossed, but I can be certain what you told me is proof of reason to confirm what you want to accomplish rather than whatever it is that I had thought beforehand. Vulpes and I have always been together. She's my companion in more ways than one, and if my fox organoid can get along with your Wolfe then maybe...just maybe we can too. I trust that you told me the truth, Jack. And I'm grateful that you saved my life and gave me a place to stay while I recover. I'll never forget your kindness tonight, and I'll pay you back someway...somehow no matter what life throws at us. So...let's get back to finishing eating this delicious food and we will see what happens next." She smiled, giving him a playful push before going back to the dinner table to finish her food.

 Jack laughed heartily at that with a nod. Perhaps fate did have something big in store for them.

 He can't be sure of what, but judging by the way Riley accepted him for who he was and not for his fame or occupation - that perhaps he'll know more about Riley and maybe something more will come from spending quality time together. Though..he'd have to tread carefully as just that close contact alone already awakened an undying urge inside of him that Jack knew could make it or break it for him. It'll take time, and a bit of luck on his side to see if Riley too felt the same way.

[innonurse]

What happened to all the fitness bands?

- By InnoNurse Staff -

Smartwatches are the go-to wearable these days, but why is it so difficult to find basic, low-cost alternatives like the fitness bands of yesteryear?

Read more at The Verge

///

Other recent news and insights

Scientists use artificial intelligence to shed light on various varieties of Parkinson's disease (The Francis Crick Institute)

AI-powered muscle mass measurement could improve care for patients with head and neck cancer (Dana-Farber Cancer Institute)

A 'mini-brain' study at the Mayo Clinic reveals a possible crucial link to autism spectrum disorder (Mayo Clinic News Network)

Stream Platform, FluidAI's artificial intelligence-powered postsurgical monitor, is now available globally (FluidAI Medical/PRNewswire)

[smukher2]

Article: Could there soon be digital copies of your heart? #BBC https://www.bbc.com/reel/video/p0hnb26m/could-there-soon-be-digital-copies-of-your-heart-

Article: Barcelona Startup Creates 3D Models Of Diseased Hearts Using High-Performance Cloud Computing #Forbes https://www.forbes.com/sites/oracle/2019/03/06/barcelona-startup-creates-3d-models-of-diseased-hearts-using-high-performance-cloud-computing/

ArticleSummary: "The goal is to get a virtual heart that is as close as possible to the diseased heart of the patient. ELEM grew out of work done at the Barcelona Supercomputing Center and is now using cloud-based high-performance computing from Oracle in hopes of bringing those models to everyday use by doctors and the healthcare industry. ELEM runs a version of Alya Red on Oracle Cloud Infrastructure’s Bare Metal Instances, which gives the company full control over the hardware, software, and infrastructure—and doctors can use the software with no queuing."

By #www.smukher2.com #www.smukher2.eu #www.smukher2.co.uk #www.smukher2.org #www.smukher2.net #smukher2 to #Everyone: A digital twin of the heart is like a "complicated heart" from the MLTR song. Let's break down this idea to understand it better.

A digital twin is a virtual model that copies a physical system. It lets us simulate, predict, and improve things without needing real prototypes. These twins can be simple or complex, using tech like machine learning to give insights. NASA first came up with digital twins, and now we have different kinds, from basic copies to intelligent ones that learn and make decisions on their own. In healthcare, they help with personalized medicine, running hospitals, and planning clinical trials. With AI, the Internet of Things (IoT), and sensors, digital twins are growing in many fields. In medicine, they're helping with precise treatments for diseases like cancer and improving how we make decisions for patients.

The article talks about making a digital copy of the heart. The central idea is that DNA makes RNA, which makes proteins. Proteins do important jobs in cells and organisms, like humans or mice. They act as enzymes and cause reactions that lead to what we see, called the phenotype. To understand diseases, which are bad phenotypes, we need to know about the organism at all levels. This helps us find treatments. For years, scientists have studied DNA, RNA, proteins, and phenotypes using animal models, cell cultures in 2D and 3D, and getting data like ECGs, blood pressure, genetic sequencing, and MRI images. But why do we need digital twins now? Well, these animal models and cultures give us lots of useful data. However, a digital twin combines all this data. It's tough for people to analyze all this info, but computers, especially with AI, can handle and study it easily.

Modeling the heart helps us understand how diseases change it compared to healthy hearts. These models have been used to figure out how the heart works and doesn't work in sickness, and to create treatments. Models can be based on animals, human cells in 2D, or organoids in 3D. When we collect data over time, we add the dimension of time, making it 4D. Now, we have tons of data from genomes, health records, wearable devices, and various imaging techniques. Computers and AI can manage and analyze this big data. So, we turn it digital, creating a digital twin of a patient's data.

The Human Cell Atlas made a Heart Cell Atlas with gene expression data from adult human hearts. Researchers used special techniques to look at the cells in different heart areas. They found unique cell types and genes in each region. Although the Atlas shows this in 3D, it's presented in 2D, and you can't view it in full 3D online. The Allen Brain Atlas, however, offers both adult and developmental data for mouse and human brains in 3D. Understanding development is key for studying diseases in organs like the heart and brain.

In these 3D maps, or atlases, you see where different cells are, plus the fourth dimension of age and the fifth dimension of gene expression. Imagine adding even more data, like EEGs, blood pressure, MRI images, and gene-protein binding. The Cardiac Atlas Project is a database with cardiac images for research and education. If you mix this with the Heart Cell Atlas's gene data, you get a 5D digital twin. Adding dimensions bit by bit will help build a complete digital twin of organs like the heart or brain. These twins can teach us about the organ and predict how drugs will work, making them super useful.

Digital twins in healthcare are changing things big time. They help hospitals work better, design medical stuff, plan surgeries, run virtual clinical trials, and give care just for you. They also help find new drugs and ways to check for diseases. Digital twins for wellness are also popping up to help people stay healthy and get care that fits them perfectly. Digital Twins for health rely on extensive health data of a human being, including sensitive personal health information. Strict measures must be in place to ensure patient privacy, data encryption, secure storage, and compliance with relevant data protection regulations.

References: 3D interactive Heart gene expression by location https://3d-cardiomics.erc.monash.edu.au 3D interactive Heart MRI by location Cardiac Atlas Project and UK BioBank https://www.cardiacatlas.org/biventricular-modes/ 3D Interactive Brain gene expression by location https://atlas.brain-map.org Human Cell Atlas https://data.humancellatlas.org Heart Cell Atlas https://www.heartcellatlas.org 3D-cardiomics: A spatial transcriptional atlas of the mammalian heart - Journal of Molecular and Cellular Cardiology #Elsevier https://www.jmcc-online.com/article/S0022-2828(21)00190-5/abstract Allen Reference Atlases :: Atlas Viewer https://atlas.brain-map.org Cardiac Atlas Project https://www.cardiacatlas.org "Complicated heart" quote from the Michael Learns To Rock (MLTR) album 'Greatest Hits Strange Foreign Beauty' https://genius.com/Michael-learns-to-rock-complicated-heart-lyrics

[escapistsatellite]

https://www.pixiv.net/en/artworks/54024152

Sea Serpent type wild Zoid A mysterious being that has existed in a freshwater lake in the hinterland for a long time. They have a friendly personality and are highly intelligent, and sometimes they help local fishermen drive fish into their traps. He has a delusion that he is actually an organoid that awakened in an ancient ruin at the bottom of a lake.

by R・のぶを