#serum creatinine

[sameerrazobyte]

 Affordable Serum Creatinine test in Kolkata: Check Kidney Health Today”

One of the most reliable ways to access kidney function is through a Serum Creatinine test in Kolkata they maintain kidney health and overall well-being the center provides reliable and quick testing and patients can receive accurate results without breaking the bank labs center give you offer home collection services without extra charges it give us to you affordable rates you can booking slots schedule with according to your time he’s staff will be visit booking after 1 hour. Don’t wait ensure your kidneys are functioning well by getting testing today.

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[daignostics123]

Get reliable, and accurate Biochemistry Creatinine, Serum with Lucid Diagnostics! Our expert team provides timely and precise results you can trust. Contact us today to schedule your appointment.

[health-today-info]

Unlocking the Secret to Kidney-Friendly Eating: Managing Creatinine Levels Through Diet

Maintaining optimal kidney health is essential for overall well-being, and one crucial aspect of kidney health is monitoring creatinine levels. Creatinine is a waste product generated by muscle metabolism and excreted by the kidneys. High levels of creatinine in the blood can indicate impaired kidney function. While genetics and other factors play a role, your diet can significantly influence your creatinine levels. 

One of the most common methods for measuring creatinine levels is through a creatinine serum test, which involves a simple blood draw to provide valuable insights into your kidney health.

In some cases, healthcare professionals may also use the BUN to creatinine ratio test, which compares the levels of blood urea nitrogen and creatinine in the blood, to gain a more comprehensive understanding of kidney function and potential issues related to the urinary tract.

In this article, we'll explore the connection between diet and creatinine levels and provide valuable insights on what you need to know to keep your kidneys in top shape.

Understanding Creatinine

Before delving into the dietary factors affecting creatinine levels, let's briefly understand what creatinine is and why it matters. Creatinine is produced when muscles contract, and it's transported via the bloodstream to the kidneys for filtration and removal from the body. Healthy kidneys efficiently eliminate creatinine. However, when kidney function is compromised, creatinine levels in the blood rise, signalling potential kidney problems.

Regular monitoring of creatinine levels through kidney function test, which includes  blood tests measuring glomerular filtration rate (GFR) or urine examination tests, is essential to assess the efficiency of your kidneys and detect any potential issues early on.

The Role of Diet in Creatinine Levels

Protein Intake: A significant portion of creatinine is derived from the breakdown of dietary protein. While protein is essential for overall health, excessive protein intake can raise creatinine levels, especially in individuals with compromised kidney function. People with kidney disease or those at risk should consult a healthcare professional to determine their ideal protein intake.

Fluid Intake: Staying adequately hydrated is crucial for maintaining healthy kidney function. Dehydration can lead to a concentration of creatinine in the blood. On the other hand, sufficient fluid intake helps dilute creatinine levels, reducing the strain on the kidneys. Aim to drink enough water throughout the day.

Sodium (Salt) Consumption: High dietary sodium can contribute to elevated blood pressure, which can in turn affect kidney function. Reducing salt intake can help maintain healthy blood pressure and potentially lower creatinine levels.

Potassium Balance: Potassium is another important mineral that can influence kidney function. People with kidney issues may need to monitor their potassium intake as high levels can lead to increased creatinine. Conversely, too little potassium can be detrimental.

Phosphorus and Calcium: An imbalance between phosphorus and calcium in the diet can harm kidney health. Foods rich in phosphorus, such as processed foods and carbonated drinks, should be consumed in moderation.

Alcohol and Caffeine: Excessive alcohol and caffeine consumption can lead to dehydration, potentially raising creatinine levels. Moderation is key when it comes to these beverages.

Fruits and Vegetables: A diet rich in fruits and vegetables can be kidney-friendly. They provide essential vitamins, minerals, and antioxidants while being low in protein and sodium.

Conclusion

Diet plays a pivotal role in maintaining healthy creatinine levels and, consequently, optimal kidney function. By making informed dietary choices and staying hydrated, you can promote kidney health and reduce the risk of kidney problems. However, it's important to remember that individual dietary needs vary, and consult with the best nephrologists like Dr. Vidya Sagarkorla or registered dietitian is advisable, especially if you have existing kidney issues or are at risk for kidney disease. A balanced diet and regular monitoring of creatinine levels can go a long way in ensuring your kidneys stay in good shape, contributing to your overall well-being.

[primamedikatama]

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Fungsi Reagen Kimia Darah Creatinine

Reagen kimia ini dirancang khusus untuk pengukuran kuantitatif kadar kreatinin dalam serum, plasma, atau urin secara in vitro menggunakan sistem fotometrik.

Pengukuran dilakukan dengan metode Fotometrik pada panjang gelombang 500 nm, menawarkan hasil yang akurat dan andal.

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[that-one-girl-studies]

Some help for fellow Phlebotomy students!

This is the saying that helps me remember the order of draw for venipuncture:

Yellow (blood cultures)

Light (PT, PTT, Coagulation)

Stop (Chemistry testing)

Green (Any plasma test except plasma cells)

Light (Blood group, Carbon Monoxide levels, CBC)

Go (Glucose, Lactic acid, Blood alcohol levels)

And then these are the tubes and their functions!

Yellow tube:

Blood cultures

Invert 8-10x

Light blue tube:

PT

PTT

Coagulation studies.

Always draw two.

Invert 3-4x

Red, tiger, or gold tubes:

Chemistry testing

Electrolyte panel:

Bicarbonate, carbon dioxide, chloride, potassium, sodium

Basic metabolic panels:

Electrolyte panel, BUN, creatinine, glucose, calcium

Drug monitoring:

Digoxin, vancomycin, aminoglycosides, phenobarbital, phenytoin, valproic acid, methotrexate, lithium, theophylline

Comprehensive metabolic panel

Basic metabolic panel, hepatic function panel

Hepatic function panel

ALT, AST, Bilirubin, albumin, total proteins

Total cholesterol

HDL, LDL

Lipid panel

HDL, LDL, TG

Thyroid profile

T3, T4, TSH

Individual tests

Folic acid, Vitamin B12, HIV, hCG

Invert 5-6x

------------------------------------------------------------------------------

Capillary/Dermal Tubes:

Pink tube:

Blood bank studies

Rh typing

Pearl/white tube:

bDNA

Keep on ice.

Royal blue with purple or red stripe:

Toxicology

Heavy metal testing

Chain of custody.

Tan, royal blue (no stripe), or lavender:

Lead levels

Royal blue (plain):

Trace metal analysis.

Sodium Heparin

Pale yellow:

Compatibility for transplant

DNA & Paternity testing.

Chain of custody

ACD

Capillary/Dermal Tubes END

------------------------------------------------------------------------------

Dark or light green tubes:

Any plasma test EXCEPT plasma cells

C reactive protein for inflammation

Immunoglobin A measures antibodies and tests for autoimmune diseases

Liver enzymes

Bone marrow disorders

Serum HCG

Gets spun!

Lithium heparin

Sodium heparin (Dark green)

Ammonium Heparin

Invert 8-10x

Lavender tubes:

Blood group (ABO)

Carbon monoxide levels

CBC

Hemoglobin

Hematocrit

RBC

WBC

WBC w/ diff.

Platelets

Hemoglobin A1c

Rh typing

Sickle cell anemia

ANY blood cells

EDTA

Invert 8-10 times

Gray tubes:

Glucose

Glucose fasting and tolerance testing

Lactic acid

Do NOT use tourniquet

Patient does NOT need to make a fist

Blood alcohol levels:

DO NOT USE alcohol-based antiseptic

USE Chlorhexidine as an antiseptic.

Potassium Oxalate

Sodium Fluoride

Invert 8-10 times

Feel free to let me know if you have any questions, or if I missed something!! This is straight from my notebook, so it's highly likely that I missed something!

Have a wonderful day and stay safe!!

[mcatmemoranda]

If you miss three or more days of Lamictal, you have to restart it at the low dose and titrate up. If the patient gets any sort of rash whatsoever, they should stop Lamictal and never receive it again. It can cause Steven Johnson syndrome. Lamictal (lamotrigine) and Seroquel (quetiapine) are both okay for treatment of bipolar disorder in pregnancy. Lamictal is not as safe for breast-feeding a seroquel is. Lamictal can decrease the effectiveness of oral contraceptive pills. Although Lamictal can decrease the effectiveness of oral contraceptive pills, the likelihood of getting pregnant by accident is low. You start with 25 mg QD for two weeks and then increase to 50 mg QD for two weeks and then increase to 100 mg x1 week, and then increase by 50 mg every week if needing higher doses. You can go up to 200 mg a day if necessary. If you need more than that, then you can divide the dose b.i.d. You should use the lowest dose with the best effect.

Depakote and lithium should not be used in women of childbearing age.

So I asked her about lithium for bipolar disorder as well. Before starting you can check some baseline labs. At least check calcium, TSH, creatinine; monitor these as well as the serum lithium level. The therapeutic lithium level range is between 0.5 and 0.8. If the patient is acutely manic, 1.2 is a therapeutic level. When the patient is manic, serum levels of lithium are lower. When the patient is not manic anymore, he can have toxicity from increased doses that you needed during the manic episode. So you need to increase carefully and decrease it after they’re out of the manic episode. Monitor the patient two times a week with labs until they’re stable.

You can use mood stabilizers that are antipsychotics or mood stabilizers that are not antipsychotics. The mood stabilizers for bipolar disorder that are non-antipsychotics and therefore have no risk of causing tardive dyskinesia include lithium, Lamictal, Depakote, Trileptal, Tegretol. Lamictal is a moderate mood stabilizer and is not strong enough for patients with bipolar 1, who you have episodes of mania. It may be better for patients with bipolar 2, who have hypomania or not really any real manic episodes. Lamictal works for irritability as well in patients with borderline personality disorder. The antipsychotics that can be used as mood stabilizers include olanzapine, seroquel, Abilify, Latuda, vraylar, caplyta. The antipsychotics cause tardive dyskinesia because they occupy the D2 receptors. She doesn’t use Latuda as monotherapy. Vraylar has no sexual side effects. She said to stick with the lower dose, which is 1.5 mg, unless the patient is really manic. It takes 2 to 3 weeks for Vraylar to work. You can stay at the 1.5 mg dose for four weeks and then see the patient again and evaluate whether or not you want to increase the dose. Caplyta is sedating and you should tell patients to take it two hours before bedtime. Don’t start at the 42 mg dose. Use the 10.5 mg dose for elderly patients or the 21 mg dose for younger patients.

Ingrezza can treat tardive dyskinesia (send to Genoa pharmacy). Austedo is an older med for TD. Amantadine can also help.

Elderly patients should not receive benzodiazepines. You can use melatonin or trazodone for sleep problems in elderly patients. If they come to you and they are on benzos, she said you can slowly convert them to Valium (but Valium is a benzo so I’m confused by that🤷🏽‍♀️). There’s something called the UK benzo taper which is done over eight weeks.

Medication for schizophrenia include olanzapine and vraylar. Thorazine increases the risk of QT prolongation. Vraylar and caplyta do not increase weight gain. Injectable meds are also effective and are good for patients with poor compliance. If someone is of Asian descent you do gene screening before starting Lamictal. You can use Wellbutrin to treat ADHD but it’s not as effective. For children you can give them strattera, qelbree, or guanfacine, which are not stimulants. There are two classes of stimulants that can be used for ADHD which are the amphetamines and the methylphenidates. Some people have better success with one drug class or the other. So if they don’t do well on the amphetamines you can try the methylphenidates.

[renee-mariposa]

Nothing in my day-to-day job shows me the limits of modern medicine like vancomycin does. And it makes me insane.

(extremely long, somewhat incoherent nerd rant below the cut)

See, vanc is really good at, like, three things: treating MRSA (when given IV), treating ampicillin-resistant enterococcus (when given IV), and treating c diff (when administered orally ONLY). Most every use outside of that, like when it’s used to treat methicillin-susceptible staph aureus for “penicillin allergic patients” (don’t get me started on PCN allergies), actually has data that it increases risk of morbidity and mortality (i.e. harm and DEATH).

Unfortunately, due to the prevalence of multi-drug resistant organisms, vancomycin is empiric therapy for a lot of presumed infections. And it's a lot more difficult to actually tell if someone has an infection than you'd think. A lot of medical conditions imitate each other and when time is of the essence to identify what's going on, the most ethical thing is to start an antibiotic and rule out infection as the hospitalization continues. Lab techniques have gotten a lot quicker: I can remember 8 years ago, it would take 3 days just to identify what microbe the patient had in their presumed infection. These days, anno domini 2023, PCR comes back in a matter of hours, identifying gram positive/gram negative staph/strep/bacilli/etc, and it's the sensitivities that take 2-3 days. (Don't get me started on contaminated cultures.) But even with improvements in lab technique, we might not culture any microbe at all or the provider might keep vancomycin on "just in case" because we don't know IF the patient is infected, WHAT they're infected with, or if the infection will get better with a different drug.

And vancomycin is terrible on kidneys. Extremely nephrotoxic. It isn’t as bad as the 80s when the drug first came out and was called Mississippi Mud colloquially, but it will fuck the patient up if not monitored closely.

But finding the correct dose for each patient in a timely manner is nigh impossible. This is because vancomycin is renally eliminated. We have to mathematically estimate how well the kidneys are working. Unfortunately, our mathematic equation is next to useless if you are:

-Less than 50 kg

-Shorter than 5 foot tall

-Have a BMI of more than 40

-Are an adult younger than 45 (twenty-year-olds get astronomical doses that would be destructive in an older patient)

-Are older than 65 (the official definition of 'geriatric', i'm relatively sure)

-Are female (this is really only applicable if the patient is less than 50 kg or older than 65 - think: little old frail lady - we have absolutely no fucking idea how their kidneys are doing until we order the serum drug level. It is next to impossible to accurately dose vancomycin in little old ladies on the first try.)

-Are missing limbs (lots of leg amputations in the older and impoverished diabetic population!!)

-Have a lot of muscle mass (think bodybuilder or really tall guys)

Fun fact: we estimate renal function by looking at height, weight, age, birth gender (few, if any, studies on trans patients taking HRT), and a lab value called serum creatinine. Creatinine is a byproduct of muscle metabolism, I don't know the fine details, but we can generally estimate how well kidneys are working by seeing how much creatinine is in the blood: low creatinine usually means kidneys are excreting it as they 'should' be. High creatinine means there's something wrong, the kidneys aren't able to excrete it as efficiently as they 'should' be. But the effect of low muscle mass and high muscle mass haven't been studied enough to be able to adjust our mathematical equation to compensate for them. And with high BMI: we often overestimate their renal function because we don't know how to estimate their muscle mass vs their body fat.

(I work out in the boonies. ~70% of our patients have diabetes. ~80% of our patients have a BMI of greater than 35. So what I'm trying to say here is: we are shooting in the fucking dark when we're estimating the renal function of the vast majority of our patients.)

Complicating this: vancomycin is useless until it reaches steady-state concentration in therapeutic range. On one side of this problem: a lot, if not most, medical providers assume that vancomycin starts working its magic from the first dose. So we sometimes get orders for "vancomycin 1 gram now and see how the patient is doing in the morning". That isn't going to solve jack shit! That's just going to increase the incidence of microbial resistance!!

OR, like in the multiple situations I dealt with this afternoon, you make an educated guess on what regimen is going to work for the patient. You get a level 48 hours after the dose starts. And you find out that you fucking guessed wrong and the patient is subtherapeutic. It has been two fucking days and the patient hasn't started being treated for their (presumed) infection yet!! And we've increased the possibility of microbial resistance! *muffled screaming in frustration*

So what I'm trying to say here is: on almost every presumed infection that comes into the hospital (which we're guessing like 30%? 50%? of the time), we're starting an extremely toxic drug, oftentimes 100% guessing what regimen will be therapeutic, only finding out in 2 days that it is not therapeutic, and it can sometimes take days and days to titrate the dose sufficiently to find a therapeutic regimen. And sometimes we're really fucking unlucky and we destroy the patient's kidneys temporarily (or permanently! but kidneys can be very resilient so that's thankfully rare) because we guessed a regimen that's too high!! This is a fucking nightmare!!!!!!!!

And if all of this wasn't bad enough, we don't really have any drugs that do what vancomycin does therapeutically. We have things that can be used to cover some of what vancomycin does, but nothing that's equivalent AND less toxic.

Like, to fix this situation, we need:

-Better education to providers on what drugs are appropriate empiric therapy for different presumed infections (we're working on it, we are working on it)

-Better ways to estimate kidney function (there needs to be more research on kidney function in patients with BMI greater than 35!! And little old ladies!! And patients with low body weight and high body weight and amputations and...)

-Better prognostic tools to tell 1. when the patient is infected (looking at you, sepsis!!!) 2. what they're infected with

-Less-toxic antibiotics AND/OR better ways to treat infection (this would be the evolution of medicine as we know it)

And I want to be clear: vancomycin isn't bad. It's an extremely effective tool when used correctly but we often either don't have enough data to use it correctly or the provider doesn't understand that this tool is fucking useless for the job they're trying to perform.

[campcrow2]

Creatinine went down half a whole ass point so I’m finally back to about where I was pre hydronephrosis and Covid and serum sickness so…thank god!

[bluegoblinfox]

Lupus?

I have a lot of symptoms which match with lupus. I've had lots of infections this year...8 so far.

I found out yesterday that my mum had a positive ANA (anti-nuclear antibodies) blood test in the 1990s and again in early 2000s. Docs haven't really followed up on this though.

So today I've got put on my big girl pants and sent a message to my GP surgery with all of my symptoms and some pics of rashes and white fingers. I've done this in hope that I am not blown off and told I'm just stressed or anxious.

Like I am anxious about my health because I feel like shit and I've had 8 infections this year. EIGHT!

So I think my anxiety is founded and proportional to the issue.

If they don't offer me an ANA I'm going to pay for one next year. To rule out autoimmune issues if nothing else.

I just can't deal with more medical gaslighting. After being told last time I raised this it was all because I was stressed.

If anyone's interested here are my symptoms:

* Hair loss

* Fatigue (debilitating)

* headaches and migraines

* Joint pain and stiffness and inflammation

* hearing loss

* dry gritty, itchy eyes (in the middle) which water at the edges.

* rash on checks and nose and sometimes chin

* skin which goes red, then pink and then loses pigment although. Leaving white patches.

* Serum creatinine levels at the highest reference point or just over. Have been for over a year.

* stage two liver disease

* cardiomyopathy

* digestive problems

* three recent UTIs

* One recent skin infection

* three recent respiratory infections

* one recent ear infection

* one abnormal ESR recently

* one high CRP recently

* feeling generally unwell often

* apparent but as yet undiagnosed Raynauds.

[mykidneytreatment]

This video features the story of Mohammad Razi. He suffered from the adverse effects of kidney failure for the past 12 years, only to be remedied (serum creatinine reduced from 9.8mg/dL to 5.4 mg/dL in a month) and given another shot at life by Karma Ayurveda. https://youtu.be/0je1OcWKSz4

[happy-smile-flowers]

Does Metformin, a glucose-lowering drug, hurt the kidneys?

Metformin is a biguanide compound that reduces blood sugar mainly by reducing hepatic glucose output, improving insulin resistance, and reducing glucose absorption in the small intestine. It is currently one of the world's most widely used oral hypoglycemic drugs. Drug safety evaluation studies have found that Metformin has a good safety profile, no carcinogenic or mutagenic effects, and no evidence that Metformin can increase the risk of lactic acidosis. Medicilon has a professional team and experience in preclinical drug safety evaluation services, providing high-quality data and a fast turnaround time to support all drug safety evaluation studies.

Many patients are concerned about the effects of long-term metformin use on the kidneys. The drug does not directly damage the kidneys but can lead to drug accumulation when taken by patients with existing kidney damage. Both the Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes (2017 edition) and the Expert Consensus on the Clinical Application of Metformin (2016 edition) suggest that Metformin is the drug of choice for the treatment of type 2 diabetes in the absence of contraindications and intolerance, and should always be retained in the glucose-lowering regimen.

1, Benefits of Metformin.

Metformin can reduce hyperglycemia with no hypoglycemic effect on those with regular blood sugar; the drug has the following benefits in addition to hypoglycemia.

(1), Metformin has the effect of reducing body weight.

(2) Metformin has apparent cardioprotective effects and reduces the risk of cardiovascular disease in newly diagnosed and established type 2, diabetes patients.

(3) Metformin can improve lipid synthesis, metabolism, and lipid profile.

(4) Metformin significantly improved liver serological enzyme profile and metabolic abnormalities in patients with non-alcoholic fatty liver.

2, Adverse reactions and countermeasures

The main adverse reactions of Metformin are diarrhea, nausea, vomiting, gastric distension, and other gastrointestinal responses, which mainly occur in the early stage of treatment (the majority happen in the first ten weeks). Most patients can gradually tolerate them, or their symptoms disappear as the duration of treatment increases. Start taking small doses, gradually increase the amount, adjust the quantity at the right time, take with meals, and choose enteric preparations and other methods, which can reduce gastrointestinal reactions.

Three 、Does Metformin hurt the liver and kidney?

Metformin has no hepatic and renal toxicity; Metformin is absorbed through the gastrointestinal tract for blood circulation, almost does not combine with plasma albumin, does not go through liver metabolism, does not compete with liver P450 enzymes, and does not degrade in the body, but acts directly on the liver and muscle, reducing hepatic glucose isomerism and increasing muscle glucose enzymes. Therefore, Metformin is not hepatotoxic.

Metformin is mainly excreted from the urine in its original form by the kidneys and is cleared rapidly, with approximately 90% clearance in 12-24h. The renal clearance of Metformin is about 3.5 times higher than that of creatinine, and renal tubular excretion is the main route of metformin clearance. Therefore, Metformin itself is not harmful to the kidney.

However, caution should be exercised when using Metformin in people with impaired liver and kidney function. Metformin should be avoided when serum transaminases exceed three times the upper limit of normal, and patients with renal insufficiency need to adjust the dose by estimating the level of glomerular filtration rate. Clinicians or pharmacists can assess the above.

4, long-term use of Metformin, the need for appropriate supplementation of vitamin B12

Studies have shown that: the incidence of vitamin B12 deficiency in glucose patients using Metformin is 5.8%, while the incidence of vitamin B12 deficiency in glucose patients not using Metformin and people without diabetes is 2.4% and 3.3%, respectively. Therefore, long-term metformin users should monitor vitamin B12 concentration regularly and increase the intake of vitamin B12-rich foods appropriately (vitamin B12 is mainly contained in animal proteins, such as meat, animal liver, fish, shellfish, eggs, etc.) to prevent and correct vitamin B12 deficiency. If this condition occurs, vitamin B12 should be supplemented in an appropriate amount under the guidance of professional doctors.

Five 、Stop taking Metformin 48 hours before and after doing a CT examination

Diabetic patients should stop taking Metformin 48 hours before and after doing enhanced CT because it is necessary to play contrast agent before doing CT. The contrast agent belongs to macromolecular substances excreted through the kidneys. If you retake Metformin, it will increase the burden on the kidney and cause contrast nephropathy.

6, the icing on the cake: combined with other glucose-lowering drugs

There are several different drugs when taking glucose-lowering drugs, often more than Metformin. This is because the combination of glucose-lowering medications mutually increases the hypoglycemic effect, improves insulin resistance, or reduces adverse reactions.

All diabetic patients should choose the appropriate hypoglycemic drugs according to their different conditions and pay attention to the indications and contraindications of each type of drug. At the same time, it is essential to emphasize that diet therapy and diet control are the cure for diabetic patients and must be adhered to for life. Diet therapy should not be relaxed or abandoned because of oral hypoglycemic drugs or increased dosages of hypoglycemic medications.

[dagasinfilo]

it’s mad at doctors hours. wish i could even type out a rant and/or vent about it but i can’t due to brain fog i’m getting from being in pain and extremely tired bc of the superhuman feat of *check notes* running one or two short-ish errands a day every day this week except today and nothing else. been just sitting the rest of the time. too tired to even move properly most of that time. so tired having to cook at night makes me want to cry and/or explode in anger. but cbc, blood glucose, bun, creatinine, serum electrolytes, liver and tsh bloodwork back in march came out all ok so there’s literally nothing wrong with me. literally nothing. it’s all normal. not possible for anything else to be causing problems right? no other possible answer to what’s causing my symptoms other than stress. right? right? at this point i am fucking fighting for my life trying to not fall back into the “it’s actually all in my head” “i’m really actually lying about it” pit. i am so fuckig tired man! i wish my body worked! i wish my brain worked enough to be able to speak out! i wish i was heard! wish i was believed! god damn.

[colinwilson11]

Rare Kidney Disease: An In-Depth Look

There are over a hundred rare diseases that can impact the functioning of the kidneys. Some of the less common renal diseases include Alport syndrome, Medullary cystic kidney disease (MCKD), Autosomal dominant polycystic kidney disease (ADPKD), and Nephronophthisis.

Alport syndrome is a genetic disorder characterized by kidney failure and hearing loss. It is caused by mutations in genes coding for type IV collagen, which is an important component of the glomerular basement membrane in the kidneys. Over time, the glomeruli are damaged, resulting in proteinuria and declining kidney function. Approximately 1 in 5000 individuals are affected by Alport syndrome worldwide.

Medullary cystic Rare Kidney Disease involves the development of cysts in the medulla of the kidneys, which are the inner regions. Two main types are MCKD type 1 and type 2. They are inherited in an autosomal recessive pattern. Cysts accumulate over time, leading to kidney enlargement and eventual failure. MCKD has a prevalence rate of about 1 in 50,000.

Autosomal dominant polycystic kidney disease is one of the most common life-threatening genetic disorders. It is caused by mutations in the PKD1 and PKD2 genes and is inherited in an autosomal dominant pattern. Multiple cysts form in both kidneys, enlarging them considerably. Symptoms include high blood pressure, kidney pain, urinary tract infections, blood in urine and late-stage renal failure. ADPKD has an incidence of about 1 in 1000-4000.

Nephronophthisis is a tubulointerstitial kidney disease leading to end-stage renal failure during childhood or teenage years in most cases. It is inherited as an autosomal recessive or autosomal dominant trait. Tiny cysts form along the renal tubules as the disease progresses. Overall prevalence is estimated to be between 1 in 50,000 to 1 in 100,000.

Diagnosis And Management Challenges

Given the rarity of these disorders, diagnosing them accurately can prove difficult. Initial tests ordered by doctors usually include urine examination, ultrasound of kidneys, serum creatinine levels and creatinine clearance tests. However, definitive diagnosis requires specialist kidney biopsy in many cases to check for characteristic pathology changes under microscopy. Genetic testing is also important to confirm the specific type and mutation involved.

Lack of awareness about Rare Kidney Disease poses challenges in management. Patients often face delays before reaching specialist nephrologists. Limited published research means treatment protocols are still evolving for some conditions. Managing complications like hypertension, pain, infections etc. requires multidisciplinary teams. Coordinating long-term care and follow-up can be an issue as patients transition between pediatric and adult medical services.

Access To Novel Therapies

As understanding of disease pathways improves, new treatments are being developed for Rare Kidney Disease. For instance, antiviral drugs that block JC polyomavirus replication show promise against Nephropathia epidemica (a zoonotic infection causing tubulointerstitial nephritis). CRISPR gene editing is being explored as a curative approach for hereditary conditions. Drugs inhibiting ACE2/angiotensin pathways help slow ADPKD progression. Research is ongoing into stem cell therapy using patient-derived podocytes for Alport syndrome. Management of symptoms also incorporates dietary changes, lifestyle modifications and palliative care approaches. Government approvals have enabled access to orphan drugs for rare disorders in many countries.

The rare diseases impacting the kidneys remain an important public health problem due to their chronic nature and lack of standardized care protocols. Improving awareness, expediting diagnosis, streamlining multi-specialty management, facilitating clinical trials and making innovative therapies more affordable are some priorities. Coordinated global research programs are necessary to find new treatments and eventually cures for these challenging conditions afflicting patients worldwide.

Get more insights on this topic:  https://www.trendingwebwire.com/rare-kidney-disease-understanding-the-uncommon-causes-of-kidney-failure/

Author Bio

Vaagisha brings over three years of expertise as a content editor in the market research domain. Originally a creative writer, she discovered her passion for editing, combining her flair for writing with a meticulous eye for detail. Her ability to craft and refine compelling content makes her an invaluable asset in delivering polished and engaging write-ups. (LinkedIn: https://www.linkedin.com/in/vaagisha-singh-8080b91)

*Note: 1. Source: Coherent Market Insights, Public sources, Desk research 2. We have leveraged AI tools to mine information and compile it

[diagnosticpoint]

Affordable Senior Citizen Health Checkup Packages in Bhubaneswar: Prioritize Your Health

As we age, our health requires more attention and care. Senior citizens, in particular, face unique health challenges, and routine checkups become crucial in maintaining their well-being. Bhubaneswar, the capital city of Odisha, is home to several medical facilities that offer specialized health checkups designed to meet the specific needs of the elderly. In this blog, we will explore why opting for a senior citizen health checkup package in Bhubaneswar is vital and how you can prioritize your health without breaking the bank.

The Importance of Health Checkups for Senior Citizens

Aging brings about natural changes in the body, and with these changes come increased risks for a variety of health issues. Common concerns for senior citizens include cardiovascular diseases, diabetes, arthritis, and even cognitive decline. Early detection through regular health checkups can help in the timely diagnosis and management of these conditions, improving the quality of life.

With a senior citizen health checkup package in Bhubaneswar, you are essentially investing in preventive healthcare. These packages are designed to screen for common illnesses and monitor your overall health. They often include tests for vital parameters like blood sugar levels, cholesterol, kidney function, and even cancer screenings.

What Should a Senior Citizen Health Checkup Include?

Before diving into the benefits of opting for a senior citizen health checkup package in Bhubaneswar, it’s essential to understand what these checkups typically cover. While the exact tests may vary depending on the package or the facility, most comprehensive packages include the following:

Complete Blood Count (CBC) – This test measures various components of your blood, such as red blood cells, white blood cells, and platelets. It helps detect conditions like anemia, infections, and blood disorders.

Blood Sugar Test – A fasting blood sugar test is crucial for diagnosing and monitoring diabetes, a common concern for older adults.

Lipid Profile – This test checks for cholesterol and triglyceride levels, helping to assess your risk for heart diseases.

Kidney Function Test – This includes serum creatinine and blood urea nitrogen (BUN) tests to monitor kidney health.

Liver Function Test – This assesses the functioning of your liver, screening for any potential liver diseases.

Electrocardiogram (ECG) – This simple test helps evaluate heart health by measuring the electrical activity of the heart.

Bone Density Test – Bone health tends to decline with age, and this test helps in diagnosing osteoporosis or other bone-related issues.

Thyroid Function Test – Thyroid issues are common in older adults, and this test checks for abnormal thyroid hormone levels.

Urine Test – A routine urine examination can reveal kidney problems, urinary infections, or other health issues.

Chest X-Ray – This helps screen for lung conditions, especially if the patient is a smoker or has a history of respiratory issues.

Eye Checkup – A comprehensive eye exam can detect cataracts, glaucoma, or age-related macular degeneration (AMD).

Hearing Test – Hearing loss is common in elderly individuals, and a hearing test can help in early detection.

Dental Checkup – Dental health often gets neglected, but regular checkups can help detect oral cancers or gum diseases.

These tests are typically bundled together in a senior citizen health checkup package in Bhubaneswar, making it a convenient and cost-effective solution for maintaining your health.

Why Bhubaneswar?

Bhubaneswar has become a healthcare hub, offering state-of-the-art medical facilities and a range of healthcare services. Senior citizens living in or around the city have easy access to world-class diagnostics and treatment at affordable rates. Diagnostic centers in Bhubaneswar, such as Diagnostic Point, have recognized the need for affordable healthcare solutions tailored specifically for the elderly.

The city offers various senior citizen health checkup packages that cater to different needs and budgets. Whether you're looking for a comprehensive health assessment or specific tests based on your medical history, Bhubaneswar’s diagnostic centers provide a range of options.

Affordable and Accessible Healthcare

One of the key benefits of opting for a senior citizen health checkup package in Bhubaneswar is the affordability. Medical expenses can add up quickly, especially for senior citizens who may be living on a fixed income or pension. However, diagnostic centers in Bhubaneswar offer packages that are both affordable and comprehensive, allowing you to get the care you need without overspending.

Moreover, many diagnostic centers also offer home sample collection services, which can be a boon for senior citizens who may have mobility issues. This ensures that elderly individuals can get their tests done from the comfort of their home, adding another layer of convenience.

How to Choose the Right Health Checkup Package

With so many options available, how do you choose the right senior citizen health checkup package in Bhubaneswar? Here are a few tips to help you decide:

Evaluate Your Health Needs – Before opting for a package, consider your specific health concerns. If you have a history of diabetes or heart disease, look for packages that focus on these conditions.

Check the Reputation of the Diagnostic Center – Not all diagnostic centers are the same. Look for well-established centers like Diagnostic Point that have a good reputation for accuracy and professionalism.

Compare Package Contents – Some packages may include additional tests that are not necessary for your health condition, while others might miss out on important ones. Make sure the package you choose covers all essential tests.

Consider Convenience – If you're not able to visit the diagnostic center in person, choose a package that offers home sample collection services.

Look for Discounts – Many diagnostic centers offer discounts on health checkup packages for senior citizens. Keep an eye out for such offers to make the package even more affordable.

Review Customer Feedback – Before making your decision, take a look at customer reviews and feedback to get an idea of the quality of service offered by the diagnostic center.

How Often Should Senior Citizens Get Health Checkups?

Regular health checkups are crucial for senior citizens, but how often should they be done? The answer depends on your overall health and medical history. For most elderly individuals, an annual health checkup is sufficient. However, if you have a pre-existing condition like diabetes or heart disease, more frequent checkups may be recommended by your doctor.

It’s essential to consult your healthcare provider to determine how often you should undergo a senior citizen health checkup package in Bhubaneswar. They can provide guidance based on your medical history, age, and risk factors.

The Role of Preventive Healthcare in Senior Years

Preventive healthcare plays a critical role in ensuring that senior citizens lead healthy, active lives. Regular checkups help catch potential health issues early, allowing for prompt treatment and management. This not only improves the quality of life but can also extend life expectancy by keeping chronic conditions under control.

Moreover, preventive healthcare empowers senior citizens to take control of their health. It helps in building awareness about potential risks and encourages a proactive approach to maintaining well-being.

The Bottom Line: Prioritize Your Health

In conclusion, opting for a senior citizen health checkup package in Bhubaneswar is one of the best ways to prioritize your health in your golden years. These packages are tailored to meet the specific needs of the elderly, offering a range of tests that help in the early detection of common health issues.

Bhubaneswar’s healthcare infrastructure is well-equipped to provide affordable, accessible, and comprehensive health checkups. Diagnostic centers like Diagnostic Point are dedicated to offering the best services for senior citizens, ensuring they receive the care they deserve.

Remember, taking care of your health is an investment in your future. Regular health checkups can prevent complications, improve your quality of life, and help you stay active and independent for longer. So, if you haven’t already, consider scheduling a senior citizen health checkup package in Bhubaneswar today!

[adoctorx]

A complete blood count, chemistry profile, immunoglobulin test, and light chain assay are among the important blood tests doctors use to help diagnose multiple myeloma. Multiple myeloma is a type of cancer that affects the white blood cells that your bone marrow produces. Doctors can help diagnose multiple myeloma using blood tests. These measure changes in the levels of blood cells or proteins that may mean you have cancerous cells in your bone marrow. Read on to learn about the blood tests for multiple myeloma, including what their results mean and how doctors use them to aid diagnosis. Complete blood count A complete blood count (CBC) is a common blood test done to measure the levels of blood cells that are part of your immune system, such as: red blood cells, including oxygen-carrying hemoglobin and the percentage of red blood cells in your blood (hematocrit) white blood cells that can increase in number when you have cancer or an infection platelets that control blood clotting and can suggest illness when they change in levels With multiple myeloma, your red blood cells and platelets might decrease as your bone marrow loses its ability to produce enough of these blood cells. Your white blood cells might increase in early stages of multiple myeloma but also decrease as cancer affects your bone marrow. Blood chemistry profile With a blood chemistry profile, healthcare professionals use a blood sample to monitor levels of substances in your blood that multiple myeloma can affect, including: calcium, which can rise to very high levels when you have multiple myeloma albumin, which can lower drastically when you have aggressive forms of multiple myeloma creatinine, which can increase due to kidney complications related to multiple myeloma Quantitative immunoglobulin test A quantitative immunoglobulin test can measure the levels of antibodies in your blood that respond to the presence of cancerous cells and changes in what your bone marrow can produce. With multiple myeloma, you’ll typically show higher levels of antibodies called immunoglobulins on your test results. Kidney disease that develops from multiple myeloma can also cause lowered immunoglobulin levels. Doctors may need to use this test alongside other tests to confirm a diagnosis of multiple myeloma. Electrophoresis A serum protein electrophoresis (SPEP) and immunofixation test — sometimes just called an electrophoresis test — involves placing a blood sample on a piece of paper that’s given an electric shock. This test can split up antibodies into visible bands that help a healthcare professional note which antibodies are present. When you have multiple myeloma, a doctor may see a band of M proteins made by cancerous myeloma cells on the paper. Serum-free light chain assay A serum-free light chain (SFLC) assay can help diagnose light chain myeloma, a subtype of multiple myeloma. Doctors often request this test when an electrophoresis test doesn’t show the presence of any M proteins. For the SFLC assay test, a healthcare professional will draw a blood sample to test it for the presence of light chain antibodies in your blood. Light chains are a part of what makes up immunoglobulins and are also associated with your blood plasma. High levels of light chains in your blood can suggest you have light chain myeloma. Beta-2 microglobulin test The beta-2 microglobulin (B2M) test is a tumor marker test that looks for the presence of B2M proteins in your blood. High levels of B2M in your blood can mean you have multiple myeloma or other blood or bone marrow cancers, such as chronic lymphocytic leukemia (CLL) or lymphoma. Doctors won’t use the results of a B2M test on its own to diagnose multiple myeloma on its own. But several B2M tests over time can help a doctor figure out how aggressive your cancer is or how well treatments are working. Multiple myeloma symptoms Symptoms of multiple myeloma can depend on what stage you’re in and what organs are affected.

Some symptoms you might experience include: unexplained shortness of breath feeling very thirsty nausea throwing up stomach pain losing your appetite not peeing as much as usual swelling in your legs and feet feeling drowsy or fatigued confusion chest pain unexplained seizures loss of consciousness or coma Frequently asked questions What is the most important blood test for multiple myeloma? A complete blood count (CBC) is the most important blood test for multiple myeloma. A CBC test can clearly show levels of immune cells that are directly related to multiple myeloma. However, to confirm a diagnosis, doctors will often need to consider results from a serum-free light chain assay along with your symptoms and imaging. Would myeloma show up in a routine blood test? An increase in your red or white blood cells on a routine blood test can mean that you have an active infection or cancer. If a doctor notices an increase in these immune cells, they might order other diagnostic tests to look for other signs of infections or cancer. These tests will help them to confirm a diagnosis or rule out conditions. Are blood tests enough to diagnose multiple myeloma? Blood tests are not usually enough to confirm a diagnosis of multiple myeloma. If your blood test results suggest you might have multiple myeloma, a doctor will also perform a biopsy to test a sample of your bone marrow for the presence of cancerous cells. Imaging tests, such as a CT scan or MRI, can also help confirm a diagnosis of multiple myeloma with detailed images of the affected bones or organs. Takeaway Numerous blood tests can help diagnose multiple myeloma by showing increased or decreased levels of blood cells and proteins. Contact a doctor if you’re concerned that you have multiple myeloma and want help confirming a diagnosis.