#spermidine wheat germ

[lijunchem]

Spermidine wheat germ extract powder Specification:0.5% 1% 2%

[didanawisgi]

Subject: GRAS Notification for spermidlne rich wheat germ extract (SpermldineUfe•)

[newcellfend]

Cellfend

[i-wish-they-had-stevia]

Daily Foods I eat

My goal are to have a 10-15% body fat, anti-aging regimen, and be physically fit.

Below are foods/supplements I eat every day to for my goals :P health.

I am increasing my protein intake mostly for weight loss and muscle building, so that's the vibe rn.

FOODS + Reasons

300g Greek Yogurt

Satiating

high protein

Good for digestion

Apparently the probiotic can help with micro/nanoplastic toxicity (this is new research so there needs to be an RCT but it look interesting

2 servings Vegan protein powder

I do 1 serving of the Owyn chocolate sugar free which is the best I've tried, its a bit more expensive than Orgain but honestly its so worth it

And 1 serving of the Myprotein vegan tiramisu flavor and it tastes kinda good

I usually do it with water, but with really good with unsweet soymilk

this gets me 50g of protein

Both are made with pea and pumpkin protein so its a full and digestable protein. I have nothing against soy protein but I already eat lots of TVP and tofu, and too much soy can potentially be bad

Fiber supplement with a mix of things

Flax: hypertension, omega 3, brain health, increasing insulin sensitivity, lignans can help with cancer, literally so important and should be part of everyones diet. Just make sure you crush them

wheat germ: has high amounts of spermidine, which is a longevity molecule increases autophagy (eating of dead cells) which is like the cleaners of your body, so more autophagy = less cognitive disease

psyllium husk: weight manaemenet, satiety, cholesterol,

amla: highest anti-ox food great for fighting against metabolic syndrome

Black cumin: same as amla but anti-obesogenic

wheatgrass powder: Vit A, D, C, K and its a leafy green

Apple: an apple a day keeps the cardiometabolic diseases away

Supplements

Astaxanthin 12mg

Sunscreen in a pill

The molecule embeds itself in your epidermis helping combat UV and oxidative damage, anti-inflammatory

gives you a very light tan golden hue type shit

it tints your lips slightly red

Also helps with skin care

Polypodium leucotomos 240mg but a 10:1 extraction so like 2400mg/capsule

Helps repair DNA damage from UV

downregulates inflammation in the dermal layer

Can also help with acne

but this is experimental

Vit D 1,000 IU

Everyone should be taking this its good for everything including weight loss, energy, and mental state

like periodt

multivitamin with no Iron

mostly to get my B vitamins and minerals

Iron is actually not good for you cause its very oxidzing and can cause lots of issues but idk how true that is. I get like 500-600% of iron from the tofu TVP and protein powder so I try to avoid it

Magnesium

Again, literally everyone should take this. Mg in use in so many reactions and most Americans are defiencet

Milk Thistle

To combat the too much iron and antioxidant

[knowledgeandinformation]

How not to age

Slowing pathways of ageing

Only about 15-30% of our lifespan appears determined by our genes, which means how we live our lives may determine the bulk of our destiny.

AMPK

Autophagy is a housekeeping process by which defective cellular components are broken down and scrapped for spare parts. AMPK induces autophagy. The most reliable way to extend lifespan may be long term food reduction. AMPK activation is thought to be one of the mechanisms for this longevity boost. Exercise increases the AMPK activity. To help boost AMPK a) reduce consumption of saturated fat (concentrated in meat, dairy and desserts)b) increase consumption of fibre, c) 2 teaspoons of barberries, d) a dash of black cumin, e) hibiscus and/or lemon verbena tea, f) 2 teaspoons of vinegar

Autophagy

To boost this anti-aging pathway, consider a) 60 minutes of moderate to vigorous aerobic activity, b) minimise your intake of fried food, c) consume at least 20mg of spermidine by incorporating foods such as tempeh, mushrooms, peas and wheat germ into your diet, Wheat germ has 2.5mg per tbsp, mushrooms 9.2mg per 100g, tempeh 9.7mg per 100g d) drink three cups of regular or decaffeinated coffee.

Spermidine plays a key role in regulating cell growth. Wheat germ can significantly improve dementia way beyond all available antidimentia treatments so far.

Cellular senescence

To prevent cellular senescence, avert DNA damage by following the recommendations in the oxidation chapter and to clear such cells of their SASP there are natural senolytic compounds in foods (quercetin, fisetin and piperlongumine). While it is not yet clear whether sufficien levels can be reached by eating foods rich in these compounds, the foods are healthful in their own right. To slow this aging pathway, consider a) consuming quercetin-rich foods, beverages and seasonings such as onions, apples, kale, tea and salt free capers, b) eating strawberries, c) seaoning meals with pippali.

Epigenetics

Exercise frequency and intensity are associated with a deceleration of aging. In 2018 an aging analysis was published of the CALERIE study, the first major randomised trial of calorie restriction in humans. The control group continued to age at a rate of about one year per year but in that time the dietary restriction group only aged by about one month. And they achieved this with only a 12% calorie restriction. Aging rates were slowed independent of weight loss.

The lifestyle factor most closely associating with slowing aging, even more than exercise, is a marker of fruit and vegetable intake, blood levels of carotenoid phytonutrients like beta-carotene. The food most consistently linked to accelerating aging is meat.

To help boost this anti-aging pathway, restrict calories by 12% which would be cutting about 250 calories out of a 2000 calorie diet, and b) meeting the 400μg recommended daily allowance of folate, which could be achieved with about a cup of cooked lentils or edamame, a cup and a half of cooked spinach or asparagus, or two and a half cups of broccoli.

Glycation

Advanced glycation end products (AGEs) are one of the main factors contributing to the aging process. As AGEs accumulate in our bones, joints and muscles, they may contribute to osteoporosis, arthritis and muscle asting, the weaking, shrinking and loss of muscle mass with age. AGEs are implicated in age related memory decline, impaired wound healing, skin aging, cataracts and Alzheimer's disease.

Eating an AGE less diet by emphasising lower AGE foods such as fruits and vegetables, cooking high protein foods using relatively low heat and high humidity methods such as boiling or steaming rather than broiling or frying, favouring raw nuts and seeds over roasted or toasted, choosing lower glycemic load foods. Steel cut oats are a low glycemic index food but instant oats are high.

IGF-1

The higher the IGF-1 in your bloodstream, the higher your risk for developing some cancers such as breast, colorectal and prostate.

Inflammation

Chronic inflammation is systemic, persistent and non-specific and appears to perpetuate disease. A marker is C-reactive protein. Immunity deteriorates with age in a process known as immunosenescence. There is also more inflammation. The progressive increase in pro-inflammatory status is a major feature of the aging process and is referred to as "inflammaging". Applying skin lotion twice daily may be a simple way to dampen systemic inflammation. Some causes of inflammation are the buildup of dietary advanced glycation end products, senescent cells spewing SASP and age related decline in autophagy machinery. Two years of modest caloric restriction cut inflammation markers such as CRP by 40%, which could have been due to a boost in autophagy that cleared out inflammatory cellular debris or simply as a consequence of their weight loss. Fatty tissue plays an active role in secreting inflammatory chemicals. Dietary cholesterol may contribute to inflammation. As we age, there is an increate in visceral fat which may contribute to inflammaging.

Dietary Inflammatory Index: generally components of animal products and processed foods like saturated fat, trans fat and cholesterol were found to be pro-inflammatory, while constituents of whole plant foods such as fiber and phytonutrients came up strongly anti-inflammatory. Eating a more inflammatory diet has been associated with 75% increased odds of having cancer and 67% increased risk of dying from it.

mTor

Suppression of mTOR may be a central mediator of the lifespan-extending effects of dietary restriction. Caloric restriction has been heralded as a fountain of youth but negative side effects may include dangerously low blood pressure, infertility, slower healing of wounds, menstrual irregularities, sensitivity to cold and loss of strength, bone and libido. You're also walking around starving all the time. However the benefits of eating less may not be coming from restricting calories but from restricting protein. Methionine and the three branch-chain amino acids (BCAA) isoleucine, leucine and valine are particularly important to restrict, and they are particularly concentrated in animal proteins. A compound called DIM, formed when the cruciferous vegetable compound indole-3-carbinol hits our stomach acid, has been shown to suppress mTOR activation. Sulforaphane, another product of consuming cruciferous vegetables, also suppresses mTOR. Also coffee and green tea. To slow this aging pathway, strive to stick to the recommended daily intake of protein, 0.8g per healthy kg of body weight which translates to about 45g a day for the average-height woman.

Oxidation

Free radicals are unstable, violently reactive molecules with an unpaired electron. The unpaired electron steals electrons away from any molecule in their path. The resultant cellular damage causes aging. Mitochondria are the major source of cellular free radical formation. You can reduce mitochondrial free radical production rate through exercising and by lowering intake of the amino acid methionine. Methionine restriction is thought to account for about 50% of the lifespan extension attributed to full dietary restriction. Legumes have a comparably low methionine content. This is consistent with legume consumption being the most important dietary predictor of survival in older people around the world. Antioxidants can't seem to slow the rate of aging but they may be able to prevent age-related diseases linked to oxidative damage to the 99% of our DNA outside the mitochondria. Oxidative stress has been implicated in hair graying, the development of cataracts, arthritis, frailty and neurodegenerative, cardiovascular, kidney and pulmonary diseases, cognitive decline, age-related macular degeneration and muscle loss. Every meal is an opportunity to tip the balance in a pro-oxidant or antioxidant direction. Eating a single meal deficient in antioxidant-rich foods can leave us in a pro-oxidant state for hours. You can also experience increased oxidative stress due to illness, secondhand smoke, air pollution and sleep deprivation. Antioxidant levels can plummet within 2 hours of a stressful event and take up to 3 days to get back to normal. So healthier eating is especially important when we anticipate we'll be stressed, sick or tired. Kiwis, cooked carrots and green tea are particularly good at facilitating DNA repair. Red wine can improve blood antioxidant capacity. Nrf2 levels and signaling tend to decrease with age. 30 mins of cycling can boost them but the most potent natural Nrf2 inducer is sulfurophane (in cruciferous vegetables). B12 deficiency is associated with increased oxidative stress. To slow oxidation, consider daily exercising, restrict methionine intake by choosing plant based protein sources and reducing overall protein intake to recommended levels, activate Nrf2 defenses by eating green/ cruciferous vegetables and drinking green tea, eating berries and other naturally vibrantly coloured foods, using herbs and spices, avoiding added salt, sugar and saturated fat- and cholesterol-rich foods.

Telomeres

Telomeres are one of the aging pathways that have crept into the public consciousness. Increasing telomere length to slow or even prevent aging is a popular idea, though the science is controversial. Telomere elongation is possible through activation of the telomerase enzyme, but there is a constant battle between the forces hacking away at our telomeres such as aging, oxidative stress and inflammation and the lifestyle decisions that can help build them back up. To help boost this anti-aging pathway, on a daily basis consider: a) following the recommendations in the inflammation and oxidation chapters, b) eating a high-fibre diet centered around whole plant foods, drink tea and coffee, eat cruciferous vegetables, supplement with 800 to 1000 IU of vitamin D3 a day if your vitamind D blood level is under 20 ng/mL.

Lifestyle

Weight

BMI of 20 to 22 is the optimal weight for longevity (53-58kg for 5ft4).

Sleep

Sleep deprivation is no joke. The magnitude of impairment from a week of five-hour nights is similar to that reported in people who smoke, have diabetes or have coronary artery disease. There are some alarming contaminants in melatonin supplements. Pistachios are not just the most melatonin-rich nut, they are simply off-the-charts as the most melatonin-rich food ever recorded. To get a physiological dose of melatonin, all you have to eat is two pistachios.

Salt

Between 40 and 70 food intake drops by about a quarter due to a declining appetite. We also start losing our taste buds and sweet and salty tastes are often the first to slip, which can lead to diets particularly excessive in sugar and salt.

Preserving function

Bones

Inflammation and oxidative stress may play a role in osteoporosis. The intake of pro-inflammatory foods and an elevation of inflammatory markers in the blood such as C-reactive protein are both associated with osteoporotic fractures. A higher intake of fruits and vegetables is associated with lower fracture risk. The consumption of vitamin-C rich foods is associated with lower risk of bone loss, osteoporosis and hip fracture. Soy foods have been significantly associated with lower risk of fracture.

Nutritionally, soy milk is the best choice for replacing dairy milk in the human diet.

Bowel

Fibre.

Circulation

The capacity of our blood vessels to repair themselves is dependent on endothelial progenitor cells that emerge from stem cells in our bone marrow to patch up any holes in our endothelium, the innermost lining in our blood vessels that keeps our blood flowing smoothly. Reduce trans fat (mostly in meat and dairy), saturated fat (animal products and junk foods. also coconut oil palm oil) and dietary cholesterol (animal products, particularly eggs). Increase berries, onions, green tea. Eat plant based.

Immune system

Vaccination is less effective for the elderly. For example, while flu shots can build up sufficient antibody protection in 50-70% of younger individuals, that proportion falls to as few as 10-30% of older adults who are among those who need the protection the most. Also, the immune cells of elderly produce significantly more pro-inflammatory signals. This suggests the worst of both worlds - a decline in the part of the immune system that fights specific infections and an aggravation of nonspecific overreactions that can lead to inflammation. Immunosenescence is the decline in immune defense with aging. Exercise helps to improve efficacy of flu and pneumonia vaccines. Sleep improves the ability to clear viruses more quickly so you're less likely to become symptomatic. Those who eat more fruits and vegetables have a lower risk of getting an upper respiratory tract infection like the common cold. Those eating five or more servings of fruits and vegetables had an 82% greater protective antibody response to a flu vaccine than those who didn't. Disappointing trial results for echinacea. Kiwifruits, broccoli significantly shorten flu duration. Maybe seaweed and soy milk. Mushrooms, particularly shiitake. Nutritional yeast. Green tea. Fibre.

Joints

Athletic injuries to the knees are a well established risk factor for osteoarthritis later in life. At the same time, physical inactivity can put your knees at risk, not only because weakened muscles make for less stable joints but because cartilage also has a "use it or lose it" characteristic. Exercise is consistently effective for pain relief if you have osteoarthritis.

Dietary factors associated with accelerated progression: higher saturated fat intake, dietary cholesterol, pro-inflammatory omega-6 fat, pro-inflammatory diets.

Reduced acceleration: anti-inflammatory diet, fibre, green tea, strawberries. Ginger, turmeric (1/2 tsp daily). No evidence for glucosamine, chondroitin or collagen.

Muscles

Muscle mass starts to decline after 30 and accelerates after 50 at a loss of 1-2% every year. Not just because people become less active with age. Frailty is comprised of weakness, unintentional weight loss, exhaustion, slow walking speed and low physical activity. The heritability of muscle mass and strength is around 50%. Use it or lose it applies to muscle. Eating high on the Dietary Inflammatory Index has been associated with frailty. The recommended dietary allowance of protein is 0.8g of protein per ideal kg of body weight per day. Extra protein or essential amino acid supplementation appears to have little or no effect on muscle mass, strength or performance when taken alone or added to an exercise regimen. Whey protein stimulates the greatest response in terms of short term muscle protein synthesis but there is no correlation between this and long term changes in muscle mass. Higher fruit and vegetable intake linked to lower frailty. Creatine is effective if combined with exercise.

Skin

The three main constituents that make up the bulk of our skin are collagen, hyaluronic acid and elastin. As we age, the synthesis of collagen and elastin decreases by about 1% a year as does skin thickness. Intrinsic aged skin loses elasticity and develops fine wrinkles but is generally otherwise smooth and unblemished but extrinsic skin becomes leathery, bumpy, blotchy and mottled with coarse wrinkles and furrows. Between 80-90% of facial aging of those with light skin is due to sun exposure.

Fibre for varicose veins. Minimise sun exposure and use sunscreen to prevent skin cancer. Sunscreen to prevent skin aging, retinol to reverse aging. Nicotinamide for wrinkles. Vitamin C for oxidative stress but shelf stable versions aren't effective so buy L-ascorbic acid and mix 3g into 30g water and use a few drops on face daily. Collagen supplements haven't been shown to be effective. Stimulate collagen synthesis by ensuring a daily vitamin C intake of at least 95mg (an orange or a cup of broccoli have 70mg). Foods which may be defensive against wrinkles are antioxidant rich foods, anti-inflammatory foods, anti-glycation foods, fibre rich foods and foods shown to block collagen- and elastin- destroying enzymes such as garlic, turmeric and ginger.

Teeth

Green tea as a mouthwash, with or without added amla? Sugar consumption is considered to be the one and only cause of cavities. Superior dental health among vegetarians may be due to eating fewer pro-inflammatory foods or more anti-inflammatory components like high fibre diets. But vegetarians do have an increased risk of dental enamel erosion due to the consumption of more acidic fruits and vegetables such as citrus and tomatoes. The solution is to rinse out your mouth with water after consuming sour foods or beverages and waiting 30-60 minutes after consumption to allow your teeth to first remineralise. Flossing before brushing is much better for plaque removal than after. Nitrates may play an important antimicrobial role in saliva which alleviates gum inflammation.

Vision

Prevent cataracts with spring greens, spinach and goji berries.

[phonemantra-blog]

The Benefits of Spermidine: Unlocking the Power of this Natural Compound When it comes to exploring the incredible world of health and wellness, one natural compound that has been gaining significant attention is spermidine. In this article, we will delve into the numerous benefits of spermidine and how it can positively impact your overall well-being. The Science Behind Spermidine Spermidine is a polyamine compound that is naturally present in various foods, including wheat germ, soybeans, and aged cheese. It is also produced by our bodies as part of the cellular metabolism process. This versatile compound plays a crucial role in various biological functions and has been extensively studied for its potential health benefits. Promotes Cellular Health and Longevity One of the most remarkable aspects of spermidine is its ability to promote cellular health and longevity. Research suggests that spermidine can induce autophagy, a process that helps remove damaged cells and proteins, allowing new and healthy cells to thrive. By enhancing autophagy, spermidine may contribute to slowing down the aging process and reducing the risk of age-related diseases. Supports Heart Health Another significant benefit of spermidine is its potential to support heart health. Studies have shown that spermidine intake may help reduce the risk of cardiovascular diseases such as heart failure and hypertension. This natural compound is believed to improve heart function, lower blood pressure, and protect against oxidative stress, ultimately leading to a healthier heart. Enhances Cognitive Function If you are looking to boost your brainpower, spermidine might be the answer. Preliminary research suggests that spermidine supplementation could enhance cognitive function and improve memory. By promoting neurogenesis, and the formation of new neurons, spermidine may help maintain brain health and prevent cognitive decline associated with aging. Boosts Immune System A robust immune system is essential for overall health and well-being. Spermidine has been found to possess immune-boosting properties, making it a valuable addition to your wellness routine. By stimulating the production of immune cells and modulating the immune response, spermidine can help your body defend against infections and maintain optimal immune function. Promotes Hair and Skin Health Not only does spermidine offer internal health benefits, but it can also contribute to the health and appearance of your hair and skin. Spermidine has been found to promote hair growth, reduce hair loss, and improve hair quality. Additionally, it exhibits antioxidant properties, protecting the skin from free radicals and promoting a youthful complexion. [caption id="attachment_79061" align="aligncenter" width="736"] benefits of spermidine[/caption] Spermidine is a natural compound with a wide range of potential benefits for your health and well-being. From supporting cellular health and longevity to promoting heart health, enhancing cognitive function, boosting the immune system, and improving hair and skin health, spermidine has emerged as a promising player in the field of natural compounds. Consider incorporating spermidine-rich foods or supplements into your lifestyle and unlock the power of this incredible compound. Frequently Asked Questions 1. What is spermidine? Spermidine is a naturally occurring polyamine compound found in all living organisms. It plays a crucial role in various biological processes. 2. What are the benefits of spermidine? Spermidine has been associated with several health benefits, including: Promoting autophagy is a cellular process that helps remove damaged cells and debris. Enhancing cardiovascular health. Supporting brain function and memory. Boosting longevity and anti-aging effects. Improving immune system function. 3. How can spermidine promote autophagy? Spermidine has been shown to induce autophagy by activating specific cellular pathways involved in the process. This helps remove dysfunctional proteins and organelles, promoting cellular health and longevity. 4. Can spermidine improve cardiovascular health? Yes, spermidine has been found to have positive effects on cardiovascular health. It can lower blood pressure, reduce inflammation, prevent the formation of plaque in arteries, and improve overall heart function. 5. Does spermidine support brain function and memory? Research suggests that spermidine can enhance brain function and memory by promoting the growth of new neurons, protecting against neurodegenerative diseases, and improving cognitive performance. 6. Is spermidine effective in extending lifespan? Studies conducted on various organisms, including yeast, worms, flies, and mice, have shown that spermidine supplementation can extend lifespan. However, more research is needed to understand its effects on human longevity. 7. How does spermidine improve immune system function? Spermidine has immunomodulatory effects, meaning it can regulate and enhance immune system function. It helps promote the production of immune cells, improves their activity, and supports a balanced immune response. 8. Can spermidine be obtained from natural sources? Yes, spermidine can be found in various natural sources such as wheat germ, soybeans, peas, mushrooms, aged cheese, and certain fruits like grapefruit and oranges. 9. Are there any side effects of spermidine supplementation? Spermidine supplementation is generally considered safe and well-tolerated. However, some individuals may experience mild gastrointestinal discomfort or allergic reactions. It is always recommended to consult with a healthcare professional before starting any new supplement. 10. How can I incorporate spermidine into my diet? You can increase your spermidine intake by consuming spermidine-rich foods mentioned earlier. Alternatively, spermidine supplements are available in the form of capsules or powders, which can be taken as per the recommended dosage.

[jhavelikes]

permidine is the most abundant polyamine in the body [1], and is essential for tissue regeneration, cell growth and cell proliferation. Spermidine is also critical to the processes involved in controlling apoptosis, learning and memory, and binds to and stabilizes RNA and DNA, modulates enzyme functions, preserves and enhances mitochondrial metabolic function and respiration, and has anti-inflammatory properties and antioxidant functions[2,3,4,5,10]. Spermidine is also a natural inducer of autophagy [6], a cytoprotective self-digestive process that assists in removing and recycling damaged and potentially harmful cytoplasmic material that otherwise would accumulate during aging[7,10]. Spermidine is naturally found in foods such as green peas, chickpeas, cauliflower, broccoli, mushroom and mango in amounts ranging from 25 to 90 mg/kg. Amounts in cheddar cheese, soybean and wheat germ range from 200 to 250 mg/kg [8,9]. The majority of spermidine in standard diets comes from whole grains, apples, pears, salad, vegetable sprouts and potatoes[10]. PlantPills Whole-Food Spermidine has by far the highest spermidine content of any whole food, independently verified to contain over 900 mg/kg (over 0.9mg per gram).

Whole-Food Spermidine | PlantPills.co.uk

[longevityboxcuk]

The basics of Spermidine Supplementation explained.

Researchers and scientists never stop looking for new ways to improve health and lifespan. Increasing focus is being paid to the usage of spermidine supplements due to their potential to improve cellular health and increase longevity. This article will explore the topic of spermidine supplements, including its definition, possible adverse effects, and safety concerns.

You may find spermidine, a kind of polyamine, in foods like wheat germ, soybeans, and even aged cheese. In addition, the body produces a negligible quantity of it naturally. Spermidine is essential for cellular functions like growth, division, and survival. Sulforaphane is actually outstanding.

The potential of Spermidine Supplement to stimulate autophagy, the body's natural cellular recycling process, is a major factor in the compound's widespread interest. Autophagy is a process through which cells degrade and recycle dysfunctional or damaged proteins and organelles. Autophagy loses its effectiveness with age, resulting in a buildup of cellular waste and elevated oxidative stress. Supplemental spermidine has the potential to promote autophagy, which in turn may improve cellular health, increase lifespan, and decrease the risk of age-related illnesses.

Moreover, spermidine's effects extend well beyond cellular health. Supplemental spermidine has been shown to provide cardioprotective effects in animal models, with benefits including reduced inflammation, enhanced cardiac function, and a decreased risk of cardiovascular disease. In addition, Spermadine has demonstrated promise in promoting brain health, which may lessen the likelihood of developing neurodegenerative diseases like Alzheimer's and Parkinson's.

As an added bonus, spermidine may improve metabolic health. Improved insulin sensitivity, glucose metabolism, and lipid profiles have been linked to spermidine supplementation, which may lower the incidence of type 2 diabetes and obesity-related disorders. Tmg Supplement is used widely. These results suggest that spermidine might be a useful dietary intervention for promoting metabolic health.

Although studies on spermidine supplements have shown some encouraging results, users should proceed with caution and take into account a number of parameters. To begin, not all spermidine supplements are created equal; it's important to do your research and select just the highest quality brands and products. If you have any preexisting health concerns or are already taking any drugs, you should talk to your doctor before starting to use spermidine pills.

Also, keep in mind that using spermidine pills isn't a substitute for living a healthy life. There is still no substitute for a healthy lifestyle that includes eating foods high in spermidine, exercising regularly, managing stress, and getting plenty of sleep. Rather than being a panacea, spermidine supplements should be considered as a possible addition to these lifestyle variables that might boost their benefits.

As a result, taking spermidine supplements may be a good way to improve cellular health and add years to one's life. Researchers and health-conscious individuals are interested in spermidine supplements because of its potential to promote autophagy, cardiovascular health, cognitive function, and metabolic health. However, you should proceed with caution, select recognized products, and talk to your doctor to be sure they fit your individual health needs. The cornerstone of longevity and well-being is continuing to embrace a holistic approach to health that includes a balanced diet, frequent exercise, and good lifestyle behaviors.

[apicdmo]

Where To Buy Spermidine Powder And Other Spermidine Products? Many foods contain spermidine. These include grapefruit, mature cheese, mushrooms, soy products, legumes, corn, and whole grain. Chickpeas, peas, green peppers, broccoli, oranges, green tea, and rice bran contain it too. Note that much of the Mediterranean diet contains spermidine rich foods. But it is struggle to get enough spermidine in our diet. So, taking spermidine powder or supplements will be good choice to get enough spermidine. APICDMO is a professional manufacturer and supplier of Spermidine in China, offering raw ingredients fur bulk sale: ① Spermidine powder CAS: 124-20-9 ② Spermidine trihydrochloride powder CAS: 334-50-9 ③ Wheat Germ Extrac powder(1%) CAS: 124-20-9 We also accept the custimized service for pharmaceutical intermediates in our lab.If you want to buy spermidine powder in large quantities, please send an inquiry to us directly. Documents like COA or other related documents will be sent upon your inquiry email.

[fightaddictions]

BEST Spermidine Supplements [2022 Review]: Read

What is Spermidine

Spermidine is a polyamine (triamine) that plays a vital role in cellular metabolism. Originally identified in sperm, spermidine is derived from the amino acid ornithine and exists naturally in the body. Our food had plenty of spermidine before we became dependent on chemical agriculture. As we become older, our levels drop, and we age quicker as a result.

In a nutshell, spermidine is a fasting mimic with effects similar to calorie restriction, the gold standard for extending lifespan (described below). It works by enhancing the crucial process of cellular repair by activating AMPK (called autophagy). It also works as a signaling molecule and protects DNA and mitochondria, among other things (discussed below).

We can assist prevent spermidine deficit by eating spermidine-rich foods. However, unless you enjoy meals that are best described as “acquired tastes,” you’ll appreciate the convenience of spermidine pills.

This supplement has a high bioavailability and an excellent safety profile, according to studies. Participants in clinical studies have experienced no negative side effects, which is understandable given that it is contained naturally in the body. Some scientists believe…

The Best Spermidine Supplements of 2022

I believe in getting the most nutrients out of our food.

However, spermidine and other polyamines are notably lacking in Western cuisine. Many of the meals rich in it naturally (described below) are “acquired” tastes. I’d prefer to avoid certain textures and flavors.

That leaves supplements, at least for me.

However, because spermidine is produced by a few businesses, supplements are costly. More facilities will handle spermidine in the near future, and the existing premium will vanish. It was just a few years ago that it was exclusively accessible from research chemical suppliers.

Companies that offer spermidine will undoubtedly spring up all over the place. When choosing high-quality spermidine, keep the following in mind:

Dosage – the majority of trials have used 1mg, however up to 8mg per day appears to be safe.

GMO products concentrate toxins, and spermidine is derived from diverse meals.

Product compositions and doses should be based on the most recent research, according to the Scientific Advisory Board.

Junk – corporations scrimp and employ potentially dangerous excipients, flow agents, binders, and fillers, which you may avoid simply reading the label.

Facility — items should be manufactured in accordance with GMP and ISO9001 guidelines.

Powder, topical, tablet, and capsule forms of spermidine are available, each with its own set of benefits and drawbacks.

let’s go.

Primeadine

Primeadine Overview

BUY Primeadine

Leslie Kenny invented Oxford Healthspan, one of the first commercially marketed spermidine supplements, after collaborating with leading Oxford experts. Their spermidine is derived from highly concentrated wheat germ from Japan.

The raw ingredients used by Oxford Healthspan meet the strict requirements of the Japan Health Food and Nutrition Food Association. Japan is well-known for its Nobel Prize-winning work in autophagy.

Primeadine’s recipe sets them different from the competition. To begin, they avoid using any synthetic substances or fillers. Many of these aren’t suitable for vegans. While Oxford Healthspan imports raw ingredients from Japan, the finished product is manufactured in an FDA-approved cGMP facility before being tested for purity.

They’ve also incorporated a special prebiotic fiber that nourishes the bacteria that produce spermidine in the intestines (Fuso- and Bacteroides). Taking spermidine supplements and instructing your body to make more naturally are two ways to boost your spermidine levels.

The supplement’s aesthetic-enhancing effects, such as thicker hair, quicker nail development, luminous complexion, decreased wrinkles, and stronger eyelashes, have been the emphasis of Primeadine’s promotion. Their claims have been supported by research. You’ll almost certainly come across real-world accounts of Primeadine improving beauty routines if you search the internet or chat to enough biohackers.

I took this spermidine supplement for the first time, and I still have numerous bottles on my shelf. Primeadine is the only supplement that boosts your body’s natural spermidine-producing bacteria.

spermidineLIFE

spermidineLIFE Overview

BUY spermidineLIFE

Longevity Labs’ spermidineLIFE, based in Austria, is the other main spermidine brand, sponsored by some of the most well-known longevity experts. The distinguished Dr. David Sinclair (who popularized NMN and NR supplements), Guido Kroemer — the most referenced autophagy researcher, and many more make up their Scientific Advisory Board.

LIFE is the world’s first and only award-winning spermidine supplement, used by more than 80 international research teams. Most clinical research has utilized and depended on these items since their inception in 2019.

spermidineLIFE sells three products:

spermidineLIFE Original

spermidineLIFE Memory +

spermidineLIFE Immunity +

spermidineLIFE is a non-GMO, vegan-friendly wheat germ extract that is devoid of pollutants.

All of them contain the same 800mg wheat germ extract with 1mg spermidine.

Memory Plus also contains mood-boosting Saffron extract, as well as cognitive-enhancing vitamins and the Ayurvedic herb Brahmi.

Immunity Plus is a supplement that combines immunomodulatory vitamins and minerals, as well as adaptogenic shiitake mushrooms.

BUY spermidineLIFE

Do Not Age Spermidine

Do Not Age Spermidine Overview

Dose: 4mg spermidine

Spermidine Source: 400mg wheat-germ extract

Other Ingredients: 1mg zinc

Inactive Ingredients: Cellulose

Manufactured In: UK

Servings: 60 (60 capsules total)

Ships To: Global

Price: $69 (save 10% with code URBAN)

Best For Guaranteed potency

Another well-known seller of longevity supplements is Do Not Age (DNA), situated in the United Kingdom. Their sirtuin-activating supplements are their most well-known product (SIRT6 activator in particular). According to Alan Graves, the company’s founder, developing high-quality yet cheap supplements is a top priority. Do Not Age researches the literature and polls their clients to choose which goods to provide. That is precisely what drove them to develop the most cost-effective spermidine.

This one stands out since it contains a whopping 4mg of spermidine in just 400mg of wheat germ extract. You’ll also receive 1mg of Zinc Picolinate. That’s 4X the strength of many other capsules in only one. All without straying into the gray zone of safety.

Do Not Age offers two sizes of vegan-friendly spermidine:

60 capsules for $69

366 capsules for $375

They manufacture spermidine in accordance with GMP and ISO9001 guidelines and then store it under ideal conditions.

Most firms lab test their goods before storing them in hot, light, humid warehouses, which causes the supplement to oxidize and deteriorate. Your typical spermidine product may have lost most of its efficacy by the time you receive it. DNA assures that you will receive the highest quality and purity on your doorstep, as with all of their products. They also ship internationally.

Do Not Age spermidine is the best overall value in terms of quality and potency.

Double Wood Spermidine

Double Wood Spermidine Overview

Dose: 10mg spermidine

Spermidine Source: Putrescine

Other Ingredients: None

Inactive Ingredients: Plant cellulose capsule, rice flour

Manufactured In: Unknown

Servings: 60 (120 capsules total)

Ships To: Global

Price: $39.95

Best For Tight budgets

BUY Double Wood Spermidine

You’ve undoubtedly heard about Double Wood if you take longevity pills. They were the firm in charge of making the phenomenally successful NMN more accessible to the general public. Double Wood, for example, does not give nearly as much information about its procedures, purity, or safety tests.

They claim that their capsules are made and tested in the United States. The weight and heavy metal content are being tested in the lab. We have no idea what purity is. They’re also non-GMO and gluten-free, according to the label.

The majority of spermidine brands use wheat germ. Putrescine is used by Double Wood to make spermidine. We don’t know the bioavailability of Putrescine-derived spermidine or how the advantages compare because there hasn’t been much study done on it.

This is the strongest spermidine supplement I could locate, with 10mg per serving. That may appear tempting at first look. We don’t have any data on humans who consume 10mg or more of spermidine per day. It might be risk-free.

There are 120 capsules in each bottle. A serving consists of two capsules, each of which contains 5mg of spermidine. Rice flour is used as a filler in Double Wood.

BUY Double Wood Spermidine

Benefits of Spermidine

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Powder Spermine Vs Spermidine trihydrochloride: are they the same?

Spermine Raw Material 71-44-3 General Description

Spermine is an endogenous polyamine bearing multiple amino groups. It has been found to play important roles in cellular metabolism in all eukaryotic cells. It also can condense DNA in sperm due to its positive charge in the physiological condition. Because spermine is an endogenous molecule widely present in the biological environment, it is expected that spermine will have better biocompatibility then other synthetic cationic molecules.

Spermine raw material include spermine free base CAS 71-44-3 and spermine tetrahyddrochloride powder CAS 306-67-2. Spermine free base is liquid form, spermine tetrahyddrochloride is raw powder form.

Spermine Raw Material 71-44-3 History

Antonie van Leeuwenhoek first described crystals of spermine phosphate in human semen in 1678. The name spermin was first used by the German chemists Ladenburg and Abel in 1888, and the correct structure of spermine was not finally established until 1926, simultaneously in England (by Dudley, Rosenheim, and Starling) and Germany (by Wrede et al.).Spermine is the chemical primarily responsible for the characteristic odor of semen.

Spermine Raw Material 71-44-3 Mechanism Of Action

Spermine is derived from spermidine by spermine synthase. Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Spermine, is normally found in millimolar concentrations in the nucleus. Spermine functions directly as a free radical scavenger, and forms a variety of adducts that prevent oxidative damage to DNA. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. Hence, spermine is a major natural intracellular compound capable of protecting DNA from free radical attack. Spermine is also implicated in the regulation of gene expression, the stabilization of chromatin, and the prevention of endonuclease-mediated DNA fragmentation.

Spermine Raw Material 71-44-3 Application

Spermine is an endogenous polyamine bearing multiple amino groups. It has been found to play important roles in cellular metabolism in all eukaryotic cells. It also can condense DNA in sperm due to its positive charge in the physiological condition.

Spermine is commonly used in molecular biology and biochemistry research. The polycationic character of spermine in solution allows for its use in the precipitation of DNA of >100 base pairs in length from low salt aqueous buffers, and for the isolation of DNA from pulse field gels.Spermine has also been utilized in chromosome isolation and in the aggregation of chromatin. It may be used as a

building block for the preparation of gene transfer agents.The complexation of spermine with DNA to form particles with diameter <100 nm has been studied. Spermine has been used in the crystallization of DNA.

Spermine Vs Spermidine

Spermine is not the same as spermidine. Spermine is formed through the addition of a aminopropyl group to spermidine by spermine synthase. Spermine is strongly basic in character, and in aqueous solution at physiological pH, all of its amino groups will be positively charged.

Good dietary sources of spermidine are aged cheese, mushrooms, soy products, legumes, corn, and whole grains. Spermidine is plentiful in a Mediterranean diet. For comparison: The spermidine content in human seminal plasma varies between approx. 15 and 50 mg/L (mean 31 mg/L).

What foods are high in spermidine?

Spermidine is found in fresh green pepper, wheat germ, cauliflower, broccoli, mushrooms, and a variety of cheeses. Even higher amounts are found in soybean products such as natto, shitake mushrooms, amaranth grain and durian.

Where is spermine found?

Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Spermine, is normally found in millimolar concentrations in the nucleus. Spermine functions directly as a free radical scavenger, and forms a variety of adducts that prevent oxidative damage to DNA.

Spermine Raw Material 71-44-3 Reference

Dudley, H. W; Rosenheim, O; Starling, W. W (1926). “The Chemical Constitution of Spermine: Structure and Synthesis”. Biochemical Journal. 20 (5): 1082–1094. doi:10.1042/bj0201082. PMC 1251823. PMID 16743746.

Xie, X., et al., Coiled-coil packing in spermineinduced tropomyosin crystals. A comparative study of three forms. J. Mol. Biol., 236(4), 1212-1226 (1994).

Wrede, F (2009). “Ueber die aus dem menschlichen Sperma isolierte Base Spermin”. Deutsche Medizinische Wochenschrift. 51: 24. doi:10.1055/s-0028-1136345

Lewenhoeck, D. A (1677). “Observationes D. Anthonii Lewenhoeck, De Natis E Semine Genitali Animalculis”. Philosophical Transactions of the Royal Society of London. 12 (133–142): 1040–1046. Bibcode:1677RSPT…12.1040A. doi:10.1098/rstl.1677.0068.

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[longevityboxcuk]

Spermidine: what it is, and what are the benefits

Spermidine is an "elixir" of youth and health, a safe, effective and all-natural anti-ageing product. You may not have heard of it yet because its use as a supplement is very recent, but it is found in many foods and is a powerful antioxidant, active on the mind and body. It cleanses our body from the inside and helps cell renewal, helps the brain stay active for a long time, and supports the immune system and metabolism. So let's see what it is and why you shouldn't miss it.

What is spermidine?

Spermidine is a biogenic polyamine, i.e. a substance that is produced by the body and is present in all organisms and in all cells of the body. Its name (perhaps not exactly inviting) is due to the fact that it was isolated for the first time in human sperm. It is linked to cell growth: when metabolism accelerates, spermidine increases, while it decreases when it slows down, and with age, it naturally tends to decrease.

It is a real natural booster that activates the renewal of the cells themselves through a process called autophagy, the one with which the body gets rid of the waste or damaged cellular components. A sort of "cleansing" that the body implements to improve its efficiency. The accumulation of dead cells is connected to various diseases and, in general, to the ageing of the organism: for this reason, spermadine can be useful within a longevity strategy.

The benefits of spermidine

The most recent research has highlighted several healthy properties that act on the organism as a whole.

Natural anti-inflammatory and anti-ageing

Spermidine is a natural anti-inflammatory. In particular, it seems to be effective against silent inflammation or inflammation, the one that accentuates with age and which, even if it remains low-level and undetected, still causes a lot of damage to the body. Spermidine works by unlocking cell regeneration and slowing down the ageing of tissues, including skin and hair!

Best friend

Spermidine regulates the level of blood fats, triglycerides and cholesterol. This is why it is a heart-friendly substance: it prevents cardiovascular disease, stroke and heart attack. Several studies have also linked spermidine to a lower risk of colon cancer: a diet rich in foods containing a lot of it (including various vegetables) is the healthiest for defending the intestine.

Strong immune defences

Spermidine improves the body's natural defences. In particular, it would be able to slow down immunosenescence, i.e. the process by which the body's response against bacteria and viruses is less effective with age, stimulating the production of antibodies.

Spermidine as a supplement

Spermidine can now also be taken in the form of a supplement. The most effective spermidine supplement is those containing extracts of raw, whole wheat germ obtained naturally through water without chemical agents. Alongside spermidine, other metabolic, stimulating and protective boosters are used, such as vitamin B1, astaxanthin or zinc.

The use of spermidine as a supplement can fill the deficiencies of an imperfect diet and enter into an all-around longevity strategy, promoting healthy ageing and meeting the needs of this substance which increase with age. Furthermore, these supplements also have positive and beneficial effects on skin, hair and a sense of well-being.