#CSF

[wikipediapictures]

Cerebrospinal fluid

“4 vials of human cerebral spinal fluid of normal appearance, collected via lumbar puncture from the L3/L4 disk space.” - via Wikimedia Commons

[therogue704]

Chancellor Palpatine is dead? Oh no! OH NO! OH-

...no

[potter-solomons]

Been in the hospital since Friday. Getting a lumbar puncture (spinal tap) tomorrow. My optical nerves are swollen and my eyes have too much CSF built up behind them. They tried a spinal tap yesterday but after 3 pokes I vomited and they had to stop. Lemme tell you, getting your spinal bone poked by a needle is PAINFUL AS F. I've got pain meds and they've been taking good care of me. That and HP Marathon on tv along with Ghosts or Friends on my phone.

Thank you @hecatemoon87 and @quarterpastmidnight for giving me the talks while I've been here.

Also, here are my boyos. I misses them.

Po, Joey and Alfie Bear (sweet pea).

[mcatmemoranda]

Oligoclonal bands (OCBs) are bands of immunoglobulins that are seen when a patient's blood serum, or cerebrospinal fluid (CSF) is analyzed. They are used in the diagnosis of various neurological and blood diseases. Oligoclonal bands are present in the CSF of more than 95% of patients with clinically definite multiple sclerosis.

Two methods of analysis are possible: (a) protein electrophoresis, a method of analyzing the composition of fluids, also known as "SDS-PAGE (sodium dodecyl sulphate polyacrylamide gel electrophoresis)/Coomassie blue staining", and (b) the combination of isoelectric focusing/silver staining. The latter is more sensitive.[1]

For the analysis of cerebrospinal fluid, a sample is first collected via lumbar puncture (LP). Normally it is assumed that all the proteins that appear in the CSF, but are not present in the serum, are produced intrathecally (inside the central nervous system). Therefore, it is normal to subtract bands in serum from bands in CSF when investigating CNS diseases. A sample of blood serum is usually obtained from a clotted blood sample taken around the time of the LP.

[bpod-bpod]

Fluid’s Bad Influence

Cerebrospinal fluid induces resistance to chemotherapy in glioblastoma (GBM) brain tumour cells – clues to improved therapy strategies for this hard to treat aggressive cancer

Read the published research paper here

This is International Brain Tumour Awareness Week – 29.10–5.11 2023

Image from work by Brett W. Stringer, Manam Inushi De Silva and Zarina Greenberg, and colleagues

South Australian Health and Medical Research Institute (SAHMRI), Laboratory for Human Neurophysiology and Genetics, Adelaide, SA, Australia

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Science Advances, October 2023

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[000callum]

// NEWSHORE WAY // (callum’s save file)

——————————————————-

gallery id: callumhambidge01

san sequoia / gilbert gardens neighbourhood

30 x 20

3 bedroom

3 bathroom

home recording studio

art room

lot traits: n/a

lot challenges: n/a

[er-cryptid]

Cerebrospinal Fluid

ko-fi

[algoentremanos]

Cómo conseguir que Cloudflare y el firewall CSF se lleven bien

Una de las cosas que tienes que tener en cuenta cuando conectas tu dominio a Cloudflare y tienes instalado un Firewall en tu servidor, por ejemplo CSF, es que este firewall puede empezar a bloquear las conexiones de Cloudflare como un loco. Y es algo que podemos evitar con cierta facilidad configurando listas blancas en el firewall para que se ignoren las IP de Cloudflare. Te voy a contar cómo…

[ananymouss]

aparent iar imi stalkereste un măr contul?? te simti??

[devine-landminds]

My spinal fluid gotta be 1/3 tequila by now

[eixeasway]

Insider reports indicate that Don Cho, head of the Common Security Force, has ordered an increase in security around the Grand Councillor and Council members.

The Government under Squ Bai has notified President Swapardeshi on a speech she will make in Assembly tomorrow.

[om-gay]

Adventures in Self Hosted Email

Photo de Yannik Mika sur Unsplash It has been a while since I’ve updated the situation on moving oh.mg to a self hosted email method, and let me tell you there is absolutely no fucking… … thing to report. It has been going well actually, pretty normal for once. There is a bit of a delay sometimes and I discovered this is down to Leafnode taking resources when the internal machines connect to…

[bishiglomper]

YA KNOW WHAT

I think I MIGHT actually have a mild brain fluid leak 🤔

Listen listen listen-

My nose. Is constantly wet. The wells at the bottom of my nostrils just always have water in them. I am CONSTANTLY just dabbing at it with a tissue. All fuckin' day.

And I can use said tissue, a normal kleenex ALL day. Because it dries like water. Theres no slime or stickiness so it doesnt get stiff or crinkled.

Also, it does absolutely no good to blow my nose. A little bit of extra water comes out, but it doesn't like. Bring down anything.

I dont have drainage down my throat. I don't know if that's for or against my theory though. 👀

I have been sneezing a shit ton. So, allergies are still a possability. ☝

I think this has been going on for over a year. I think it's also gotten worse the last several months because I'm way more aware of it and thus annoyed.

I constantly have a tissue to my nose shoving it up there to absorb as much moisture as I can at once, I'm sure it's not very attractive.

The other thing is my ears leak. Just at night. Every night. My nose is fine though. Like they SWITCH. And I'm a side sleeper.

The fluid coming out of my ears is clear. My ears themselves are clean. They don't get waxy.

I've have tried searching all sorts of ways to figure out how my ears would leak from allergies, like I've been told it was, but I'm still getting that it would be wax. I don't have swimmers ear or infection. I know THIS has been going on for several years.

I don't remember if antihistimines stop any of this, I will experiment further with that. 👀

There's a few dozen other symptoms that come with CSF. I have maybe 1/4 of them.

Neck pain and stiffness. I don't know if this is caused by that or just tension.

I always have a mild headache. From 2-4. The migraine shot every month helps a lot but I'm still getting worse the last week or two before then.

I get light sensitivity so very easily. It ranges just from discomfort to straight up my eyes start watering. The other day it was super cloudy and it still felt too damn bright.

I always have vertigo. That is also at about a 3. It does get worse if i bend down but clears up after a second. (Though last night i had a more intense, several moments lasting one... vision actually blurred: another symptom)

Bending over and seeing if your face drips is a test for it, but that is SO uncomfortable for me, i tense my whole body and hold my breath and can't do it for more than a few seconds so.. That test hasnt worked for me

I do get mildly nauseous fairly regularly but i figured that was a precurser to a migraine. I'll start dry heaving If i don't take a zofran right away..

Another is balance and gait problems. 👀💦 that is a problem. I may have had that my whole life though. Though it has gotten worse the last several years. I've tried to do balance training sort of things. And my gait is just super small. (I think that's all thats wrong with it. I don't know if i zigzag or anything. It may just be a hip problem..)

CSF is usually caused by an injury. My theory is when I was 15, I went on a fair ride called the zipper. Its the pod with a weight at the other end that flings you around in a circle. Upside down and all. They sent me like 3x in a row because there wasnt a line. That was the first time I ever felt ill from a ride. I literally had to lay down for like half an hour in the grass before I could move.

And I could never go on a spinny ride ever again without getting extremely nauseous. 😥 Like just doing a slow 360 in a spinny chair makes me ill.

Breaks my heart because my FAVORITEST ride at our amusement park was that huge tube that spun so much you stick to the wall and they drop the floor. It was my life's goal to be one of those people who could turn yourself upside down then 🤣😭

So yeah, I think that's gonna be the next thing i bring up with my doctor. 🤔 I see her in a month but I might just straight up tell her "Hey I want some tests" now.

[drpedi07]

Hydrocephalus

Hydrocephalus is an excessive accumulation of cerebrospinal fluid (CSF) within brain cavities (Ventricles).

[bpod-bpod]

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Along the Pia

Forming pockets that stretch along the brain’s blood vessels, perivascular spaces serve as outlets for sluicing waste chemicals, but exactly how they work throughout our lives is a little mysterious. Investigating inside this mouse’s brain (with its cells highlighted in blue), researchers find clues in the pia mater (green) – a tender layer of brain tissue that blood vessels (red) pass through on their way into or out from the brain. It was previously thought that pia acts as a barrier, restricting the flow of brain fluids, but the scientists now believe pia acts more like a filter, adjusting the flow of chemicals in cerebrospinal fluid flowing around perivascular spaces, and potentially changing as we age. Investigating further may help to guide pia’s role in sieving out waste chemicals that may contribute to Alzheimer’s disease in later life.

Written by John Ankers

Video from work by Humberto Mestre and colleagues

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, July 2022

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