#Cancer cells NEWS

[reasonsforhope]

"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.

The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.

“These clusters alert the immune system in a much more profound way than single particles would.”

Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.

“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.

“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).

Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.

The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.

In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.

The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...

While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.

The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."

-via Good News Network, May 11, 2024

-video via University of Florida Health, May 1, 2024

[onebizarrekai]

(for the ibvs guys) what would the side effects of overexerting themselves with their powers be? i'm imagining edward drawing too much string and would start to feel faint, or would the string just... stop before he got to that point? i imagine drew could grow a tree out of his head if he was healing a massive wound or a lot of people at one time in quick succession. what about the others? can isaac just seemingly make objects forever, as long as he has the drawings to 'draw' from?

that seems about right to me, it would just cause a lot exhaustion, strain, migraines, eventually physical damage from overuse. think like nosebleeds. I don't think someone could ever overuse their power to this degree but it might even cause a seizure if used too much.

I could have sworn I wrote this down somewhere but I can't find it. if I remember right drew's power can't create that many cells while healing, so he can't do things like create new limbs. I could've sworn it said something like "his powers can restore an injury to its former state as long as it's not too complex or outside the strength of his power" but now I'm debating if healing something causes it to create new cells entirely. since I cannot seem to find my notes on this subject though, practically anything I say is subject to change.

[political-us]

The American Cancer Society:

[kirby-the-gorb]

[anewcalamity]

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A New Calamity: Page 469

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Chapter 1 • Chapter 2 • Chapter 3 • Chapter 4 • Chapter 5 • Chapter 6 • Chapter 7 • Chapter 8 • Chapter 9 • Chapter 10 • Chapter 11 • Chapter 12 • Chapter 13 • Chapter 14 • Chapter 15 • Chapter 16

[iliveinprocrasti-nationn]

doctors are like “look out for symptoms” and im like “but which ones and how do i know they’re not caused by one of my other issues” and there’s no answer

[rincent-van-uggh]

Alternatively/additionally cover up in the sun. Especially if you cant stand suncream, wear long sleeves, long legwear, wide brim hats.

Hello everybody with summer fast approaching here is your regular reminder that:

Everyone needs to wear sunscreen

SPF 50 is pretty much the best protection you can get, an SPF higher than that will have the same effect

Melanin does not protect you from skin cancer

Tanning is caused by exposure to ultraviolet radiation

Spending the majority of your life receiving regular large doses of UV radiation without any skin protection is a good way to get skin cancer

Don't use tanning beds, and don't go sun tanning

Wear your fucking sunscreen

[calculatedchimpevent]

AI is a kind of malicious homunculus

[abigailspinach]

He has unilaterally halted – as of 5 pm this evening, according to an executive memorandum first reported by independent journalist Marisa Kabas – all “grant, loan and federal assistance programs” for at least 90 days. This appears to include everything the federal government does beyond the salaries of federal employees, direct checks to Social Security and Medicare beneficiaries and the US military. Mainstream media journalists are calling this “temporary” or a “pause”. But that’s like saying you’re “temporarily” shutting down Congress or “pausing” elections. “Temporary” isn’t a meaningful term in this case. It’s hard to think through everything affected. Already the halt to USAID budgets has cut off funding for the prison guards holding 9,500 ISIS prisoners in northeastern Syria, according to Syria expert Charles Lister. Cancer research, major parts of every state’s budget, the grants that keep the local daycare center running. This hits basically everything.

The best way to understand this is that it is essentially a unilateral government shutdown on steroids. Even government shutdowns distinguish between essential and inessential government activities. This doesn’t, though it doesn’t appear to effect the salaries of government workers. If this goes into effect it will show up more or less immediately everywhere across the country, as I noted above. It is also blatantly unconstitutional and violates the Impoundment Control Act of 1974, a law intended to prevent much more targeted versions of this which had been attempted by President Nixon. In practice, it amounts to the executive illegally seizing spending authority from Congress.

This action will trigger a host of lawsuits and rapidly make its way to the Supreme Court.

Will the public accept it? This isn’t a conversation about norms or aid to a country you’ve never heard of. It will show up all over the place pretty much immediately. Federal funding for cancer research? Full stop. Various federal grants that fund parts of state and local government basically everywhere. Again, as I said, this is basically a government shut down on steroids.

The big thing to understand in terms of the Democratic opposition is that they’re out of power. This really comes down to the Courts and congressional leadership, which is all Republican. This gets to a broader reality. Whatever battles Democrats do with the Trump administration has to be asymmetric. Pretending that anything else is possible is crazy and invites failure and demoralization. That is certainly part of the design here: do all sorts of things all at once that no one can easily stop and let it become a precedent. The best response? This goes back to dominance politics. Find what you can actually do that’s not begging or meaningless and then do it. The clearest lever out there is that the White House needs a debt limit increase sometime this Spring, probably pretty soon. There’s been chatter that Republican leaders are going to try to put together a spending deal with Democratic help that would include a debt limit increase or suspension. That has to be taken off the table. No debt limit increase unless the President renounces illegal and constitutional actions. That’s the clearest place where opposition Democrats can take the initiative and force the President and GOP leadership to come to them. Anything that doesn’t force that is basically meaningless.

You’ve probably heard me say before that no one should ever play chicken with the full faith and credit of the United States. Well, these are extraordinary circumstances. But really you don’t even need to make that argument. The Republicans are in the majority. They can do this themselves if they want. The Democrats aren’t in the majority and holding anything hostage. The Republicans are the majority. It’s the majorities job, literally, to do this stuff. They can’t because they can’t get their own caucus in order. So they’re coming to the Democrats for help. It’s a perfectly reasonable condition. That’s not the only thing they should demand. There are a bunch of additional things Democrats can do that are deeper in the budget process weeds. But it’s the minimum. No cooperation without an agreement to operate only within the law and the constitution. 

[linstudy]

December 17, 2024 | fried eggs mixed in my cell culture

ooh boy… where should I start? i f*cked up. yep. mycoplasma contamination is the worst. my only consolation is that these are my *practice* cells, not the real ones i should use for my thesis. i reported to my supervisor and waiting for a feedback. anyone has any advice?

[rightnewshindi]

हिमाचल में कैंसर के 32 हजार 909 मरीज, 3 हजार 138 अस्थमा से पीड़ित; धनीराम शांडिल

Himachal Pradesh Cancer Patients: हिमाचल प्रदेश में कैंसर के 32 हजार 909 और अस्थमा के 3 हजार 138 मरीज हैं. मौजूदा वक्त में चिकित्सा शिक्षा एवं अनुसंधान हिमाचल प्रदेश विभाग के तहत जिला शिमला, कांगड़ा, सिरमौर, मंडी और हमीरपुर गवर्मेंट मेडिकल कॉलेज और अस्पताल चलाए जा रहे हैं. इन महाविद्यालय एवं चिकित्सालय में यह मरीज अपना इलाज करवा रहे हैं. यह जानकारी हिमाचल प्रदेश विधानसभा के मानसून सत्र के दौरान…

[reasonsforhope]

"A cure for HIV could be a step closer after researchers found a new way to force the virus out of hiding inside human cells.

The virus’s ability to conceal itself inside certain white blood cells has been one of the main challenges for scientists looking for a cure. It means there is a reservoir of the HIV in the body, capable of reactivation, that neither the immune system nor drugs can tackle.

Now researchers from the Peter Doherty Institute for Infection and Immunity in Melbourne, have demonstrated a way to make the virus visible, paving the way to fully clear it from the body.

It is based on mRNA technology, which came to prominence during the Covid-19 pandemic when it was used in vaccines made by Moderna and Pfizer/BioNTech.

In a paper published in Nature Communications, the researchers have shown for the first time that mRNA can be delivered into the cells where HIV is hiding, by encasing it in a tiny, specially formulated fat bubble. The mRNA then instructs the cells to reveal the virus.

Globally, there are almost 40 million people living with HIV, who must take medication for the rest of their lives in order to suppress the virus and ensure they do not develop symptoms or transmit it. For many it remains deadly, with UNAids figures suggesting one person died of HIV every minute in 2023.

It was “previously thought impossible” to deliver mRNA to the type of white blood cell that is home to HIV, said Dr Paula Cevaal, research fellow at the Doherty Institute and co-first author of the study, because those cells did not take up the fat bubbles, or lipid nanoparticles (LNPs), used to carry it.

The team have developed a new type of LNP that those cells will accept, known as LNP X. She said: “Our hope is that this new nanoparticle design could be a new pathway to an HIV cure.”

When a colleague first presented test results at the lab’s weekly meeting, Cevaal said, they seemed too good to be true.

“We sent her back into the lab to repeat it, and she came back the next week with results that were equally good. So we had to believe it. And of course, since then, we’ve repeated it many, many, many more times.

“We were overwhelmed by how [much of a] night and day difference it was – from not working before, and then all of a sudden it was working. And all of us were just sitting gasping like, ‘wow’.”

Further research will be needed to determine whether revealing the virus is enough to allow the body’s immune system to deal with it, or whether the technology will need to be combined with other therapies to eliminate HIV from the body.

The study is laboratory based and was carried out in cells donated by HIV patients. The path to using the technology as part of a cure for patients is long, and would require successful tests in animals followed by safety trials in humans, likely to take years, before efficacy trials could even begin.

“In the field of biomedicine, many things eventually don’t make it into the clinic – that is the unfortunate truth; I don’t want to paint a prettier picture than what is the reality,” stressed Cevaal. “But in terms of specifically the field of HIV cure, we have never seen anything close to as good as what we are seeing, in terms of how well we are able to reveal this virus.

“So from that point of view, we’re very hopeful that we are also able to see this type of response in an animal, and that we could eventually do this in humans.”

Dr Michael Roche of the University of Melbourne and co-senior author of the research, said the discovery could have broader implications beyond HIV, with the relevant white blood cells also involved in other diseases including cancers.

Dr Jonathan Stoye, a retrovirologist and emeritus scientist at the Francis Crick Institute, who was not involved in the study, said the approach taken by the Melbourne team appeared be a major advance on existing strategies to force the virus out of hiding, but further studies would be needed to determine how best to kill it after that.

He added: “Ultimately, one big unknown remains. Do you need to eliminate the entire reservoir for success or just the major part? If just 10% of the latent reservoir survives will that be sufficient to seed new infection? Only time will tell.

“However, that does not detract from the significance of the current study, which represents a major potential advance in delivery of mRNA for therapeutic purposes to blood cells.”"

-via The Guardian, June 5, 2025

[ralfmaximus]

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

Within 48 hours, the four human study participants showed remarkable results: their immune systems went into turbo cancer-destroying mode. And without surgery, radiation, or dangerous chemotherapy.

Folks, we may have a cure for cancer within your lifetime.

[techtoio]

Biotech Breakthroughs: Cutting-Edge Innovations That Will Change Health Care

Introduction

The field of biotechnology is at the forefront of some of the most groundbreaking advancements in healthcare. With new discoveries and innovations emerging at an unprecedented rate, biotech is poised to transform the way we approach health care. From revolutionary treatments to personalized medicine, the potential of biotech to improve lives is immense. In this article, we’ll delve into the most significant biotech breakthroughs and how they are set to change health care as we know it. Read to continue

[fagpulp]