#Code with kathiresan

[ktrkathir]

Create Custom Shape in SwiftUI

Create Custom Shape in SwiftUI - Kathiresan Murugan

Hi Friends, In this tutorial I was explained about how to create a custom Shapes in SwiftUI. In SwiftUI some Shapes was provided by Apple. Like Circle, Rectangle etc. If you need to create a new custom Shapes to show on the screen. How? Here I have a solution for this question. Shape is the one of the Protocol in SwiftUI. So, We have to create Struct with conform of Shape Protocol. Here I…

[tastydregs]

Doctors Gene-Edit Patient's Liver to Make Less Cholesterol

A team of researchers from US biotech company Verve Therapeutics have injected a gene-editing serum into a live patient's liver with the goal of lowering their cholesterol, a watershed moment in the history of gene editing that could potentially save millions from cardiovascular disease and heart attacks, MIT Technology Review reports.

The clinical trial kicked off with a patient in New Zealand receiving the unusual injection dubbed VERVE-101. Early experiments on monkeys have already yielded hopeful results.

The company claims that these genetic edits will be able to permanently lower levels of "bad" LDL cholesterol, a fatty molecule that at excessive levels can lead to clogged arteries.

And that could be a gamechanger as other interventions such as hard-to-follow diets, exercise, and other prescribed medicine have only been able to make a small dent LDL levels. Many drugs have also remained wildly expensive, with insurers refusing to pay for them, according to MIT Tech.

"VERVE-101 is a first-in-class gene editing medicine that we have designed to make a single spelling change in liver DNA to permanently turn off a disease-causing gene," said gene researcher and Verve Therapeutics founder Sekar Kathiresan in a statement.

"If this works and is safe, this is the answer to heart attack — this is the cure," Kathiresan told MIT Tech.

It's the first time a technique called "base editing," a novel take on CRISPR gene editing that substitutes DNA letters instead of cutting genes altogether, has been used in humans.

Such a technology could have dramatic implications, given how common high cholesterol is in the population.

"Of all the different genome editing ongoing on the clinic, this one could have the most profound impact because of the number of people who could benefit," Eric Topol, a cardiologist and researcher at Scripps Research, who was not involved in the research, told the publication.

Verve is now hoping to enroll around 40 adult patients with heterozygous familial hypercholesterolemia (HefH), an inherited genetic disorder that causes dangerously high cholesterol levels, to evaluate the safety and tolerability of the injection.

READ MORE: Edits to a cholesterol gene could stop the biggest killer on earth [MIT Technology Review]

More on the company: Scientists Suggest Editing Human Genetic Code to Prevent Heart Attacks

The post Doctors Gene-Edit Patient's Liver to Make Less Cholesterol appeared first on Futurism.

[manimarank]

Hi, Have you registered for your GST certificate course? If not, please do now and this course starts on 10th November 2021. Note: While paying class fees, please use the Discount code as "GSTINDIADAILY" to avail discount and pay Rs.800/- after availing of the discount. Link: https://imjo.in/h5XbFt Once you paid please share me, Acknowledgement. வணக்கம் வருகின்ற நவம்பர் 10ம் தேதி நம்முடைய ஜிஎஸ்டி வகுப்பு ஆரம்பிக்க உள்ளது. இதுவரை வகுப்பிற்கு பதிவு செய்யாதவர்களும் பணம் செலுத்தாததவர்களும் கீழே உள்ள இனைப்பில் மூலம் செலுத்தி பதிவு செய்து கொள்ளுங்கள். குறிப்பு: நீங்கள் இந்த வகுப்பிற்கு பணம் செலுத்தும் பொழுது தள்ளுபடியை பெற [Discount] "GSTINDIADAILY" என்று பதிவு செய்து ரூபாய் 2500 மதிப்புள்ள வகுப்பை ரூபாய் 800க்கு பெற்றிடுங்கள். நன்றி மணிமாறன் கதிரேசன் Thanks Manimaran Kathiresan www.gstindiadaily.com https://www.instagram.com/p/CVp5A7PPHLi/?utm_medium=tumblr

[neurogenpapers]

Rare and low-frequency coding variants alter human adult height.

PubMed: Rare and low-frequency coding variants alter human adult height. Nature. 2017 Feb 01;: Authors: Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rüeger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, Turcot V, Young KL, Winkler TW, Esko T, Karaderi T, Locke AE, Masca NG, Ng MC, Mudgal P, Rivas MA, Vedantam S, Mahajan A, Guo X, Abecasis G, Aben KK, Adair LS, Alam DS, Albrecht E, Allin KH, Allison M, Amouyel P, Appel EV, Arveiler D, Asselbergs FW, Auer PL, Balkau B, Banas B, Bang LE, Benn M, Bergmann S, Bielak LF, Blüher M, Boeing H, Boerwinkle E, Böger CA, Bonnycastle LL, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Burt AA, Butterworth AS, Carey DJ, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Galbany JC, Cox AJ, Cuellar-Partida G, Danesh J, Davies G, de Bakker PI, de Borst GJ, de Denus S, de Groot MC, de Mutsert R, Deary IJ, Dedoussis G, Demerath EW, den Hollander AI, Dennis JG, Di Angelantonio E, Drenos F, Du M, Dunning AM, Easton DF, Ebeling T, Edwards TL, Ellinor PT, Elliott P, Evangelou E, Farmaki AE, Faul JD, Feitosa MF, Feng S, Ferrannini E, Ferrario MM, Ferrieres J, Florez JC, Ford I, Fornage M, Franks PW, Frikke-Schmidt R, Galesloot TE, Gan W, Gandin I, Gasparini P, Giedraitis V, Giri A, Girotto G, Gordon SD, Gordon-Larsen P, Gorski M, Grarup N, Grove ML, Gudnason V, Gustafsson S, Hansen T, Harris KM, Harris TB, Hattersley AT, Hayward C, He L, Heid IM, Heikkilä K, Helgeland Ø, Hernesniemi J, Hewitt AW, Hocking LJ, Hollensted M, Holmen OL, Hovingh GK, Howson JM, Hoyng CB, Huang PL, Hveem K, Ikram MA, Ingelsson E, Jackson AU, Jansson JH, Jarvik GP, Jensen GB, Jhun MA, Jia Y, Jiang X, Johansson S, Jørgensen ME, Jørgensen T, Jousilahti P, Jukema JW, Kahali B, Kahn RS, Kähönen M, Kamstrup PR, Kanoni S, Kaprio J, Karaleftheri M, Kardia SL, Karpe F, Kee F, Keeman R, Kiemeney LA, Kitajima H, Kluivers KB, Kocher T, Komulainen P, Kontto J, Kooner JS, Kooperberg C, Kovacs P, Kriebel J, Kuivaniemi H, Küry S, Kuusisto J, La Bianca M, Laakso M, Lakka TA, Lange EM, Lange LA, Langefeld CD, Langenberg C, Larson EB, Lee IT, Lehtimäki T, Lewis CE, Li H, Li J, Li-Gao R, Lin H, Lin LA, Lin X, Lind L, Lindström J, Linneberg A, Liu Y, Liu Y, Lophatananon A, Luan J, Lubitz SA, Lyytikäinen LP, Mackey DA, Madden PA, Manning AK, Männistö S, Marenne G, Marten J, Martin NG, Mazul AL, Meidtner K, Metspalu A, Mitchell P, Mohlke KL, Mook-Kanamori DO, Morgan A, Morris AD, Morris AP, Müller-Nurasyid M, Munroe PB, Nalls MA, Nauck M, Nelson CP, Neville M, Nielsen SF, Nikus K, Njølstad PR, Nordestgaard BG, Ntalla I, O'Connel JR, Oksa H, Loohuis LM, Ophoff RA, Owen KR, Packard CJ, Padmanabhan S, Palmer CN, Pasterkamp G, Patel AP, Pattie A, Pedersen O, Peissig PL, Peloso GM, Pennell CE, Perola M, Perry JA, Perry JR, Person TN, Pirie A, Polasek O, Posthuma D, Raitakari OT, Rasheed A, Rauramaa R, Reilly DF, Reiner AP, Renström F, Ridker PM, Rioux JD, Robertson N, Robino A, Rolandsson O, Rudan I, Ruth KS, Saleheen D, Salomaa V, Samani NJ, Sandow K, Sapkota Y, Sattar N, Schmidt MK, Schreiner PJ, Schulze MB, Scott RA, Segura-Lepe MP, Shah S, Sim X, Sivapalaratnam S, Small KS, Smith AV, Smith JA, Southam L, Spector TD, Speliotes EK, Starr JM, Steinthorsdottir V, Stringham HM, Stumvoll M, Surendran P, 't Hart LM, Tansey KE, Tardif JC, Taylor KD, Teumer A, Thompson DJ, Thorsteinsdottir U, Thuesen BH, Tönjes A, Tromp G, Trompet S, Tsafantakis E, Tuomilehto J, Tybjaerg-Hansen A, Tyrer JP, Uher R, Uitterlinden AG, Ulivi S, van der Laan SW, Van Der Leij AR, van Duijn CM, van Schoor NM, van Setten J, Varbo A, Varga TV, Varma R, Edwards DR, Vermeulen SH, Vestergaard H, Vitart V, Vogt TF, Vozzi D, Walker M, Wang F, Wang CA, Wang S, Wang Y, Wareham NJ, Warren HR, Wessel J, Willems SM, Wilson JG, Witte DR, Woods MO, Wu Y, Yaghootkar H, Yao J, Yao P, Yerges-Armstrong LM, Young R, Zeggini E, Zhan X, Zhang W, Zhao JH, Zhao W, Zhao W, Zheng H, Zhou W, EPIC-InterAct Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium, ReproGen Consortium, MAGIC Investigators, Rotter JI, Boehnke M, Kathiresan S, McCarthy MI, Willer CJ, Stefansson K, Borecki IB, Liu DJ, North KE, Heard-Costa NL, Pers TH, Lindgren CM, Oxvig C, Kutalik Z, Rivadeneira F, Loos RJ, Frayling TM, Hirschhorn JN, Deloukas P, Lettre G Abstract Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways. PMID: 28146470 [PubMed - as supplied by publisher] http://dlvr.it/NGZn81

[ktrkathir]

Design Login screen in SwiftUI | How to make an iOS App

[ktrkathir]

Debug: Print class, function, line number swift

Debug: Print class, function, line number swift

Hi Guys, Here I created new Function to print message, class name, function name and line number. // Can call like. DebugPrint.message("Test") // Implementation enum DebugPrint { static func message(_ text: String, _ fileName: String = #file, _ function: String = #function, _ line: Int = #line) { print("\(text) \t fileName: \((fileName as NSString).lastPathComponent), function: \(function),…

[ktrkathir]

Daily Reminder Local Notification Swift 5.2

Daily Reminder Local Notification Swift 5.2

Implementing a Daily Reminder Local Notification (UNUserNotification) and build an iOS Application | Xcode 11 | Swift 5.2

No real device. No Certificate. No Provisioning profile.

Here I used UserNotification framework and implemented UNCalendarNotificationTrigger, DateComponents to set notification on every day at 12 pm.

[ktrkathir]

Simulate APNS Remote Notification on simulator iOS 13.5 and above | Xcode 11.5

Simulate APNS Remote Notification on simulator iOS 13.5 and above | Xcode 11.5

Hi EveryOne!

In this Swift tutorial. I discussed about how to trigger a push notification to Simulator iOS 13.5 and above | Xcode 11.5 and above.

No Certificate. No ProvisioningProfile. No Third party websites. No .p12 file required.

Terminal command to send Push notification to simulator.

Syntex:

$ xcrun simctl…

[ktrkathir]

Customise ActivityIndicator | Swift 5.2 | Xcode 11

Customise ActivityIndicator | Swift 5.2 | Xcode 11

Hi Buddy,

In this swift tutorial I discuss the topic of Customise ActivityIndicator out of your UIViews. This will make your code much more readable, and keep those UIViewController small.

You can use this LoadingIndicator for any other Views. That makes sense to users what was going on right now in this UI Element.

Once you implemented it will help for your entire project. Because of…

[ktrkathir]

Dark mode for iOS 10 and above

Dark mode for iOS 10 and above

Hi Friend,

Here I implemented a dark mode support for iOS 10 and above.

Follow my step by step video and learn quickly

Dark mode support for iOS 10 and above

[ktrkathir]

Location based Augmented Reality using ARKit in iOS

Location based Augmented Reality using ARKit in iOS

Hi Friends,

Its time to learn ARKit in iOS. Yes. I have start learning of ARKit in iOS.

Scope: Showing information for particular location coordinates. Like below image

Using ARKit and CoreLocation Framework‘s. Its possible to archive.

I have set of places like

var places: [Place] = [Place(name: "L", lati: 11.053791, lngi: 76.990920, id: 1),Place(name: "R", lati: 11.051854, lngi: 76.991360, id:…

[tastydregs]

Scientists Suggest Editing Human Genetic Code to Prevent Heart Attacks

Heart attacks are the world’s leading cause of death, yet the few treatments available are often expensive and inaccessible. Although that’s been the case for years, the World Health Organization warned back in 2020 heart disease numbers were still on the rise.

Verve Therapeutics says altering human genomes to prevent the buildup of bad cholesterol might be the answer, and is creating what CEO Sekar Kathiresan says may be a permanent solution to heart disease. The company is backed by Google Ventures, according to a report about the breakthrough published Friday in Bloomberg. Verve also counts a Harvard medical professor and an award-winning medical expert among its cofounders.

“We’re on the cusp of potentially transforming that model to a one-and-done treatment,” Kathiresan told the business publication.

The gene editing technique will initially be tried on individuals who have already suffered a heart attack for a hereditary condition that impacts as many as 31 million people globally. Verve uses CRISPR gene editing, a powerful but ethically complex gene tool. If this round of testing goes well, Verve may expand to larger groups of people.

While some, like Tesla and SpaceX CEO Elon Musk, worry that extended life spans aren’t a good idea for Earth, the people whose lives would be saved might feel a little differently, especially given how expensive medicine can be. It’s not uncommon for life-saving treatments, like insulin for example, to be so expensive people can’t afford it and die instead.

Affordable, accessible treatment could be just around the corner if Verve pulls this off.

More on other leading cause breakthroughs: CDC Mocked for Bizarre Tweet About Cancer Causing Cancer

The post Scientists Suggest Editing Human Genetic Code to Prevent Heart Attacks appeared first on Futurism.

[ktrkathir]

Side menu implementation Swift

Side menu implementation Swift

A Step by step tutorial about Integration and Implementation of Left sideMenu and build an iOS App

Here I Implemented tableView with SideMenu SDK to Xcode project using Swift Package Manager.

We can design our own ViewController to Left slide menu and also customise what we need.

Integration [youtube=https://www.youtube.com/wa…