#Data Recovery Agency

[dataplusrecovery]

Find the Best Data Recovery Company - Datarecoverylebanon

We are the world's Best Data Recovery Company. can check any media to see if it has been completely sanitized to ensure that all data on it has been deleted. We also have the expertise and tools to do so. Our erase verification services are beneficial to a variety of organizations, including technology manufacturers, storage integrators, and enterprises. Our service’s documented erasure verification and data security assurance benefit all customers.

USB Data Recovery is a powerful application that can restore files from a variety of USB flash drive devices, such as JumpDrive, Pen Drive, Pocket Drive, Thumb Drive, and USB memory, among others. It is regarded as the world’s best. Among these are documents, emails, photos, videos, music, and other file types.

The software solution is available as both a free download and an upgraded version that can meet more complex requirements. Despite its lower popularity, USB data recovery can be a powerful alternative to Disk Drill Data Recovery, EaseUS Data Recovery Wizard, and Recuva.

By breaking down the process into three simple steps, Safe365’s USB Data Recovery makes it simple to scan and retrieve data. The first thing you should do is run the software and install it. To access its homepage interface and begin scanning, you must click the “Start” button on your desktop. Here, you should be able to see and record the USB flash drives that are connected to your PC.

The specific storage device and file types you want to retrieve must be selected in the second step. Any and all files that were saved on your device in the past — such as audio, documents, videos, photos, emails, PDFs, and others — can be recovered. Depending on the number of contents that need to be restored, the scanning process can take anywhere from a few seconds to several minutes.

After that, a separate count will be made for each of the recoverable files. It will be shown in a folder structure alongside its name, type, size, date, and time. You will be required to select the items you want to restore to your system once more by pressing the “Record” button. The restoration process will be seamless due to the low CPU and memory usage. In the worst-case scenario, in which you accidentally lose or delete your data, USB data recovery is a useful data recovery tool that you should keep on your computer system. It is compatible with a wide range of storage media and can recover a wide variety of file types. It backs up its claim by providing world-class scanning and retrieval capabilities at the lowest possible cost.

[bondrees]

Discover the Truth with Bond Rees Investigations - Your Trusted UK Detective Agency

Uncover the truth with Bond Rees Investigations, the UK’s leading private detective agency. Our expert team offers discreet and professional services, including private investigations, lie detector tests, tracing services, corporate investigations, and data recovery. With a 98.7% success rate, we ensure confidentiality and accuracy in every case. Trust Bond Rees to provide the answers you need.

[reasonsforhope]

"One of the world's rarest cats, the Iberian lynx, is no longer classed as endangered, according to a report by the International Union for Conservation of Nature (IUCN).

On Thursday [June 20, 2024], the IUCN, which categorises species according to the level of risk they face in a "red list", bumped the Iberian lynx from "endangered" to "vulnerable" after a significant surge in numbers.

Its population grew from 62 mature individuals in 2001 to 648 in 2022. While young and mature lynx combined now have an estimated population of more than 2,000, the IUCN reports.

As the name suggests, the wild cat species calls the Iberian region - Spain and Portugal - home.

According to the latest census data, there were a total of 14 clusters where the animals were stable and reproducing. Of those, 13 were located in Spain and one in Portugal.

The wild cat used to be common across the whole of the Iberian Peninsula, but from the 1960s its numbers plummeted.

Habitat loss, poaching and road accidents all helped to push the species to the brink of extinction.

Now, the cat is coming back.

The increase is largely thanks to conservation efforts that have focused on increasing the abundance of its main food source - the also endangered wild rabbit, known as European rabbit.

Programmes to free hundreds of captive lynxes and restoring scrublands and forests have also played an important role in ensuring the lynx is no longer endangered.

Francisco Javier Salcedo Ortiz, a coordinator responsible for leading the conservation action, described it as the "greatest recovery of a cat species ever achieved through conservation".

Mr Ortiz said there was still "a lot of work to do" to ensure the animals survive and the species can recover.

"Looking ahead, there are plans to reintroduce the Iberian lynx to new sites in central and northern Spain,” he added.

The area the species occupies is now much larger, according to IUCN, jumping from 449 sq km (173 sq miles) in 2005 to 3,320 sq km today."

-via BBC News, June 20, 2024

[cringywhitedragon]

Heads up folks, NicoNicoDouga is currently down due to a large scale cyberattack

The attack happened on the 8th and the site is still down in terms of video streaming. Apparently there were reports of Ransomware being used during the attack.

The site is still “down” but the blog part is back up but from the report, videos and content posted are ok so do not fret. The site is still down as of this post (save for the blog) and it seems they are working their hardest to fix it and do damage control.

Here is a rough translation of their most recent post:

Report and apology regarding cyberattack on our services

As announced in Niconico Info dated June 8th, 2024, Dwango Co., Ltd. (Headquarters: Chuo-ku, Tokyo; President and CEO: Takeshi Natsuno) has been unable to use the entire Niconico service operated by our company since the early morning of June 8th. It has been confirmed that this outage was caused by a large-scale cyberattack, including ransomware, and we are currently temporarily suspending use of the service and conducting an investigation and response to fully grasp the extent of the damage and restore it.

After confirming the cyberattack, we immediately took emergency measures such as shutting down the relevant servers, and have set up a task force to fully clarify the damage, determine the cause, and restore the system. We would like to report the findings of the investigation to date and future responses as follows.

We sincerely apologize to our users and related parties for the great inconvenience and concern caused.

Response history>

Around 3:30 a.m. on June 8, a malfunction occurred that prevented all of our web services, including our "Nico Nico" and "N Preparatory School" services, from working properly. After an investigation, it was confirmed that the malfunction was caused by a cyber attack, including ransomware, at around 8 a.m. on the same day. A task force was set up on the same day, and in order to prevent the damage from spreading, we immediately cut off communication between servers in the data center provided by our group companies and shut down the servers, temporarily suspending the provision of our web services. In addition, since it was discovered that the attack had also extended to our internal network, we suspended the use of some of our internal business systems and prohibited access to the internal network.

As of June 14, we are currently investigating the extent of the damage and formulating recovery procedures, aiming for a gradual recovery.

June 8, 2024

We have begun an investigation into the malfunction that prevented all of our "Nico Nico" services from working properly and the failure of some of our internal systems.

We have confirmed that the cause of the failure was encryption by ransomware. "Nico Nico" services in general and some internal business systems suspended and servers were shut down

A task force was established

First report "Regarding the situation in which Nico Nico services are unavailable" was announced

June 9, 2024

Contacted the police and consulted with external specialist agencies

Kabukiza office was closed

KADOKAWA announced "Regarding the occurrence of failures on multiple KADOKAWA Group websites"

June 10, 2024

Reported to the Personal Information Protection Commission (first report)

Second report "Regarding the situation in which Nico Nico services are unavailable" was announced

June 12, 2024

Reported the occurrence of the failure to the Kanto Regional Financial Bureau (Financial Services Agency)

June 14, 2024

This announcement

This cyber attack by a third party was repeated even after it was discovered, and even after a server in the private cloud was shut down remotely, the third party was observed to be remotely starting the server and spreading the infection. Therefore, the power cables and communication cables of the servers were physically disconnected and blocked. As a result, all servers installed in the data centers provided by the group companies became unusable. In addition, to prevent further spread of infection, our employees are prohibited from coming to the Kabukiza office in principle, and our internal network and internal business systems have also been shut down.

In addition to public cloud services, Niconico uses private cloud services built in data centers provided by KADOKAWA Group companies, to which our company belongs. One of these, a data center of a group company, was hit by a cyber attack, including ransomware, and a significant number of virtual machines were encrypted and became unavailable. As a result, the systems of all of our web services, including Niconico, were shut down.

This cyber attack by a third party was repeated even after it was discovered, and even after a server in the private cloud was shut down remotely, the third party was observed to be remotely starting the server and spreading the infection. Therefore, the power cables and communication cables of the servers were physically disconnected and blocked. As a result, all servers installed in the data centers provided by the group companies became unusable. In addition, to prevent further spread of infection, our employees are prohibited from coming to the Kabukiza office in principle, and our internal network and internal business systems have also been shut down.

The Niconico Video system, posted video data, and video distribution system were operated on the public cloud, so they were not affected. Niconico Live Broadcasting did not suffer any damage as the system itself was run on a public cloud, but the system that controls Niconico Live Broadcasting's video distribution is run on a private cloud of a group company, so it is possible that past time-shifted footage, etc. may not be available. We are also gradually checking the status of systems other than Niconico Douga and Niconico Live Broadcasting.

■ Services currently suspended

Niconico Family services such as Niconico Video, Niconico Live Broadcast, and Niconico Channel

Niconico account login on external services

Music monetization services

Dwango Ticket

Some functions of Dwango JP Store

N Preparatory School *Restored for students of N High School and S High School

Sending gifts for various projects

■ About Niconico-related programs

Until the end of July, official Niconico live broadcasts and channel live broadcasts using Niconico Live Broadcast and Niconico Channel will be suspended.

Considering that program production requires a preparation period and that Niconico Live Broadcast and Niconico Channel are monthly subscription services, we have decided to suspend live broadcasts on Niconico Live Broadcast until the end of July. Depending on the program, the broadcast may be postponed or broadcast on other services.

The date of resumption of Niconico services, including Niconico Live Broadcast and Niconico Channel, is currently undecided.

Niconico Channel Plus allows viewing of free content without logging in. Paid content viewing and commenting are not available.

■ About the new version "Nico Nico Douga (Re: Kari)" (read: nikoniko douga rikari)

While "Nico Nico" is suspended, as the first step, we will release a new version of "Nico Nico Douga (Re: Kari)" at 3:00 p.m. on June 14, 2024. Our development team voluntarily created this site in just three days, and it is a video community site with only basic functions such as video viewing and commenting, just like the early days of Niconico (2006). In consideration of the load on the service, only a selected portion of the videos posted on Niconico Video is available for viewing. The lineup is mainly popular videos from 2007, and you can watch them for free without an account.

■About the Niconico Manga app

We have already confirmed that many systems were not affected, and we are considering resuming the service with a reduced-function version that allows basic functions such as reading manga, commenting, and adding to favorites. We aim to restore the service by June 2024.

If any new facts become known in the future, we will report them on Niconico Info, Official X, our company website, etc. as they become available. We appreciate your understanding and cooperation.

Added 6/10]

Thank you for your continued patronage. This is the Niconico management team.

Due to the effects of a large-scale cyber attack, Niconico has been unavailable since the early morning of June 8th.

We sincerely apologize for the inconvenience.

As of 6:00 p.m. on June 10th, we are working to rebuild the entire Niconico system without being affected by the cyber attack, in parallel with an investigation to grasp the full extent of the damage.

We have received many inquiries from you, such as "Will premium membership fees and paid channel membership fees be charged during the service suspension period?" and "What will happen to the time shift deadline for live broadcasts?". We are currently in the process of investigating the impact, so we cannot answer your questions, but we will respond sincerely, so please wait for further information.

Our executive officer Shigetaka Kurita and CTO Keiichi Suzuki are scheduled to explain the expected time until recovery and the information learned from the investigation up to that point this week.

We will inform you again about this as soon as we are ready.

■ Services currently suspended

Niconico Family Services such as Niconico Video, Niconico Live Broadcast, Niconico Channel, etc.

Niconico Account Login on External Services

[Added 2024/06/10 18:00]

Gifts for various projects (due to the suspension of related systems)

■ Programs scheduled to be canceled/postponed (as of June 10)

Programs from June 10 to June 16

■ Current situation

In parallel with the recovery work, we are investigating the route of the attack and the possibility of information leakage.

No credit card information has been leaked (Niconico does not store credit card information on its own servers).

The official program "Monthly Niconico Info" scheduled for June 11 at 20:00 will be broadcast on YouTube and X at a reduced scale. During this program, we will verbally explain the current situation in an easy-to-understand manner. (※There is no prospect of providing additional information, such as detailed recovery dates, during this program.)

"Monthly Niconico Info" can be viewed at the following URL. YouTube → https://www.youtube.com/@niconico_news X (formerly Twitter) → https://x.com/nico_nico_info

The latest information will be posted on Niconico Info and the official X (formerly Twitter).

We deeply apologize for the inconvenience caused to users and content providers who regularly enjoy our videos and live broadcasts. We ask for your understanding and cooperation until the issue is resolved.

Published on 6/8]

Thank you for your continued patronage. This is the Niconico management team.

Currently, Niconico is under a large-scale cyber attack, and in order to minimize the impact, we have temporarily suspended our services.

We are accelerating our investigation and taking measures, but we cannot begin recovery until we are confident that we have completely eliminated the effects of the cyber attack and our safety has been confirmed. We do not expect to be able to restore services at least this weekend.

We sincerely apologize for the inconvenience.

We will inform you of the latest situation again on Monday (June 10, 2024).

■ Suspended services

Niconico family services such as Niconico Video, Niconico Live Broadcast, and Niconico Channel

Niconico account login on external services

■ Current situation

In parallel with the recovery work, we are investigating the route of the attack and the possibility of information leakage.

No credit card information has been confirmed to have been leaked (Niconico does not store credit card information on its own servers).

Future information will be announced on Niconico Info and Official X (formerly Twitter) as it becomes available.

We deeply apologize to all users who were looking forward to the video posts and live broadcasts scheduled for this weekend. We ask for your understanding and cooperation until the response is complete.

[covid-safer-hotties]

also preserved on our archive

by Rowan Walrath

Public and private funding is lacking, scrambling opportunities to develop treatments

In brief Long COVID is a difficult therapeutic area to work in. It’s a scientifically challenging condition, but perhaps more critically, few want to fund new treatments. Private investors, Big Pharma, and government agencies alike see long COVID as too risky as long as its underlying mechanisms are so poorly understood. This dynamic has hampered the few biotechnology and pharmaceutical companies trying to develop new medicines. The lack of funding has frustrated people with long COVID, who have few options available to them. And crucially, it has snarled research and development, cutting drug development short.

When COVID-19 hit, the biotechnology company Aim ImmunoTech was developing a drug for myalgic encephalomyelitis/chronic fatigue syndrome, better known as ME/CFS. As more people came down with COVID-19, some began to describe lingering problems that sounded a lot like ME/CFS. In many cases, people who got sick simply never seemed to get better. In others, they recovered completely—or thought they had—only to be waylaid by new problems: fatigue that wouldn’t go away with any amount of rest, brain fog that got in the way of normal conversations, a sudden tendency toward dizziness and fainting, or all the above.

There was a clear overlap between the condition, which patients began calling long COVID, and ME/CFS. People with ME/CFS have a deep, debilitating fatigue. They cannot tolerate much, if any, exercise; walking up a slight incline can mean days of recovery. Those with the most severe cases are bedbound.

Aim’s leaders set out to test whether the company’s drug, Ampligen, which is approved for ME/CFS in Argentina but not yet in the US, might be a good fit for treating long COVID. They started with a tiny study, just 4 people. When most of those participants responded well, they scaled up to 80. While initial data were mixed, people taking Ampligen were generally able to walk farther in a 6 min walk test than those who took a placebo, indicating improvement in baseline fatigue. The company is now making plans for a follow-on study in long COVID.

Aim’s motivation for testing Ampligen in long COVID was twofold. Executives believed they could help people with the condition, given the significant overlap in symptoms with ME/CFS. But they also, plainly, thought there’d be money. They were wrong.

“When we first went out to do this study in long COVID, there was money from . . . RECOVER,” Aim scientific officer Chris McAleer says, referring to Researching COVID to Enhance Recovery (RECOVER), the National Institutes of Health’s $1.7 billion initiative to fund projects investigating causes of, and potential treatments for, long COVID. McAleer says Aim attempted to get RECOVER funds, “believing that we had a therapeutic for these individuals, and we get nothing.”

Instead of funding novel medicines like Ampligen, the NIH has directed most of its RECOVER resources to observational studies designed to learn more about the condition, not treat it. Only last year did the agency begin to fund clinical trials for long COVID treatments, and those investigate the repurposing of approved drugs. What RECOVER is not doing is funding new compounds.

RECOVER is the only federal funding mechanism aimed at long COVID research. Other initiatives, like the $5 billion Project NextGen and the $577 million Antiviral Drug Discovery (AViDD) Centers for Pathogens of Pandemic Concern, put grant money toward next-generation vaccines, monoclonal antibodies, and antivirals for COVID-19. They stop short of testing those compounds as long COVID treatments.

Private funding is even harder to come by. Large pharmaceutical companies have mostly stayed away from the condition. (Some RECOVER trials are testing Pfizer’s COVID-19 antiviral Paxlovid, but a Pfizer spokesperson confirms that Pfizer is not sponsoring those studies.) Most investors have also avoided long COVID: a senior analyst on PitchBook’s biotech team, which tracks industry financing closely, says he isn’t aware of any investment in the space.

“What you need is innovation on this front that’s not driven by profit motive, but impact on global human health,” says Sumit Chanda, an immunologist and microbiologist at Scripps Research who coleads one of the AViDD centers. “We could have been filling in the gaps for things like long COVID, where pharma doesn’t see that there’s a billion-dollar market.”

The few biotech companies that are developing potential treatments for long COVID, including Aim, are usually funding those efforts out of their own balance sheets. Experts warn that such a pattern is not sustainable. At least four companies that were developing long COVID treatments have shut down because of an apparent lack of finances. Others are evaluating a shift away from long COVID.

“It is seen by the industry and by investors as a shot in the dark,” says Radu Pislariu, cofounder and CEO of Laurent Pharmaceuticals, a start-up that’s developing an antiviral and anti-inflammatory for long COVID. “What I know is that nobody wants to hear about COVID. When you say the name COVID, it’s bad . . ., but long COVID is not going anywhere, because COVID-19 is endemic. It will stay. At some point, everyone will realize that we have to do more for it.”

‘Time and patience and money’ Much of the hesitancy to make new medicines stems from the evasive nature of long COVID itself. The condition is multisystemic, affecting the brain, heart, endocrine network, immune system, reproductive organs, and gastrointestinal tract. While researchers are finding increasing evidence for some of the disease’s mechanisms, like viral persistence, immune dysregulation, and mitochondrial dysfunction, they might not uncover a one-size-fits-all treatment.

“Until we have a better understanding of the underlying mechanisms of long COVID, I think physicians are doing the best they can with the information they have and the guidance that is available to them,” says Ian Simon, director of the US Department of Health and Human Services’ Office of Long COVID Research and Practice. The research taking place now will eventually guide new therapeutic development, he says.

Meanwhile, time marches on.

By the end of 2023, more than 409 million people worldwide had long COVID, according to a recent review coauthored by two cofounders of the Patient-Led Research Collaborative (PLRC) and several prominent long COVID researchers (Nat. Med. 2024; DOI: 10.1038/s41591-024-03173-6). Most of those 409 million contracted COVID-19 and then long COVID after vaccines and antivirals became available. That fact undercuts the notion that the condition results only from severe cases of COVID-19 contracted before those interventions existed. (Vaccination and treatment with antivirals do correlate with a lower incidence of long COVID but don’t prevent it outright.)

“There is that narrative that long COVID is over,” says Hannah Davis, cofounder of the PLRC and a coauthor of the review, who has had long COVID since 2020. “I think that’s fairly obviously not true.”

The few biotech companies that have taken matters into their own hands, like Aim, are often reduced to small study sizes with limited time frames because they can’t get outside funding.

InflammX Therapeutics, a Florida-based ophthalmology firm headed by former Bausch & Lomb executive Brian Levy, started testing an anti-inflammatory drug candidate called Xiflam after Levy’s daughter came down with long COVID. Xiflam is designed to close connexin 43 (Cx43) hemichannels when they become pathological. The hemichannels, which form in cell membranes, would otherwise allow intracellular adenosine triphosphate (ATP) to escape and signal the NLRP3 inflammasome to crank up its activity, causing pain and inflammation.

InflammX originally conceived of Xiflam as a treatment for inflammation in various eye disorders, but after Levy familiarized himself with the literature on long COVID, he figured the compound might be useful for people like his daughter.

InflammX set up a small Phase 2a study at a site just outside Boston. The trial will enroll just 20 participants, including Levy’s daughter and InflammX’s chief operating and financial officer, David Pool, who also has long COVID. The study is set up such that participants don’t know if they’re taking Xiflam or a placebo.

Levy says the company tried to communicate with NIH RECOVER staff multiple times but never heard back. “We couldn’t wait,” he says.

Larger firms are similarly disconnected from US federal efforts. COVID-19 vaccine maker Moderna appointed a vice president of long COVID last year. Bishoy Rizkalla now oversees a small team studying how the company’s messenger RNA shots could mitigate problems caused by new and latent viruses, including SARS-CoV-2. But Rizkalla says Moderna has no federally funded projects in long COVID.

Federal bureaucracy has slowed down research in other ways. When long COVID appeared, Tonix Pharmaceuticals was developing a possible drug called TNX-102 SL to treat fibromyalgia. The two conditions look similar: they’re painful, fatiguing, and multisystemic, and fibromyalgia can crop up after a viral infection.

But it wasn’t easy to design a study to test the compound in long COVID. Among other issues, the US Food and Drug Administration initially insisted that participants have a positive COVID-19 test confirmed by a laboratory, like a polymerase chain reaction test, to be included in the study. At-home diagnostics wouldn’t count.

“We spent a huge amount of money, and we couldn’t enroll people who had lab-confirmed COVID because no one was going to labs to confirm their COVID,” cofounder and CEO Seth Lederman says. “We just ran out of time and patience and money, frankly.”

Tonix had planned to enroll 450 participants. The company ultimately enrolled only 63. The study failed to meet its primary end point of reducing pain intensity, a result Lederman attributes to the smaller-than-expected sample size.

TNX-102 SL trended toward improvements in fatigue and other areas, like sleep quality and cognitive function, but Tonix is moving away from developing the compound as a long COVID treatment and focusing on developing it for fibromyalgia. If it’s approved, Lederman hopes that physicians will prescribe it to people who meet the clinical criteria for fibromyalgia regardless of whether their condition stems from COVID-19.

“I’m not saying we’re not going to do another study in long COVID, but for the short term, it’s deemphasized,” Lederman says.

Abandoned attempts Without more public or private investment, it’s unclear how research can proceed. The small corner of the private sector that has endeavored to take on long COVID is slowly becoming a graveyard.

Axcella Therapeutics made a big gamble in late 2022. The company pivoted from trying to treat nonalcoholic steatohepatitis, a liver disease, to addressing chronic fatigue in people with long COVID. In doing so, Axcella reoriented itself exclusively around long COVID, laying off most of its staff and abandoning other research activities. People in a 41-person Phase 2a trial of the drug candidate, AXA1125, showed improvement in fatigue scores based on a clinical questionnaire (eClinicalMedicine 2023, DOI: 10.1016/j.eclinm.2023.101946), but Axcella shut down before it could get its planned 300-person follow-on study up and running.

The fate of AXA1125 may be to gather dust. Axcella’s former executives have moved on to other pursuits. Erstwhile chief medical officer Margaret Koziel, once a champion of AXA1125, says by email that she is “not up to date on current research on long COVID.” Staff at the University of Oxford, which ran the Phase 2a study, were not able to procure information about the planned Phase 2b/3 trial. A spokesperson for Flagship Pioneering, the venture firm that founded Axcella in 2011, declined to comment to C&EN.

Other firms have met similar ends. Ampio Pharmaceuticals dissolved in August after completing only a Phase 1 study to evaluate an inhaled medication called Ampion in people with long COVID who have breathing issues. Biotech firm SolAeroMed shut down before even starting a trial of its bronchodilating medicine for people with long COVID. “Unfortunately we were unable to attract funding to support our clinical work for COVID,” CEO John Dennis says by email.

Another biotech company, Aerium Therapeutics, did manage to get just enough of its monoclonal antibody AER002 manufactured and in the hands of researchers at the University of California, San Francisco, before it ended operations. The researchers are now testing AER002 in a Phase 2 trial with people with long COVID. Michael Peluso, an infectious disease clinician and researcher at UCSF and principal investigator of the trial, says that while AER002 may not advance without a company behind it, the study could be valuable for validating long COVID’s mechanisms of disease and providing a proof of concept for monoclonal antibody treatment more generally.

“[Aerium] put a lot of effort into making sure that the study would not be impacted,” Peluso says. “Regardless of the results of this study, doing a follow-up study now that we’ve kind of learned the mechanics of it with modern monoclonals would be really, really interesting.”

‘A squandered opportunity’ In 2022, the NIH’s National Institute of Allergy and Infectious Diseases (NIAID) put about $577 million toward nine research centers that would discover and develop antivirals for various pathogens. Called the Antiviral Drug Discovery (AViDD) Centers for Pathogens of Pandemic Concern, the centers were initially imagined as 5-year projects, enough time to ready multiple candidates for preclinical development. The NIH allocated money for the first 3 years and promised more funds to come later.

The prospect excited John Chodera, a computational chemist at the Memorial Sloan Kettering Cancer Center and a principal investigator at an AViDD center called the AI-Driven Structure-Enabled Antiviral Platform. Chodera figured that if his team were able to develop a potent antiviral for SARS-CoV-2, it could potentially be used to treat long COVID as well. A predominant theory is that reservoirs of hidden virus in the body cause ongoing symptoms.

But Chodera says NIAID told him and other AViDD investigators that establishing long COVID models was out of scope. And last year, Congress clawed back unspent COVID-19 pandemic relief funds, including the pool of money intended for the AViDD centers’ last 2 years. Lawmakers were supposed to come through with additional funding, Chodera says, but it never materialized. All nine AViDD centers will run out of money come May 2025.

“When we do start to understand what the molecular targets for long COVID are going to be, it’d be very easy to pivot and train our fire on those targets,” says Chanda from Scripps’s AViDD center. “The problem is that it took us probably 2 years to get everything up and going. If you cut the funding after 3 years, we basically have to dismantle it. We don’t have an opportunity to say, ‘Hey, look, this is what we’ve done. We can now take this and train our fire on X, Y, and Z.’ ”

Researchers at multiple AViDD centers confirm that the NIH has offered a 1-year, no-cost extension, but it doesn’t come with additional funds. They now find themselves in the same position as many academic labs: seeking grant money to keep their projects going.

Worse, they say, is that applying for other grants will likely mean splitting up research teams, thus undoing the network effect that these centers were supposed to provide.

“Now what we’ve got is a bunch of half bridges with nowhere to fund the continuation of that work,” says Nathaniel Moorman, cofounder and scientific adviser of the Rapidly Emerging Antiviral Drug Development Initiative, which houses an AViDD center at the University of North Carolina at Chapel Hill.

“This was a squandered opportunity, not just for pandemic preparedness but to tackle these unmet needs that are being neglected by biotech and pharma,” Chanda says.

Viral persistence Ann Kwong has been here before. The virologist was among the first industry scientists trying to develop antivirals for hepatitis C virus (HCV) back in the 1990s. Kwong led an antiviral discovery team at the Schering-Plough Research Institute for 6 years. In 1997, Vertex Pharmaceuticals recruited her to lead its new virology group.

Kwong and her team at Vertex developed a number of antivirals for HCV, HIV, and influenza viruses; one was the HCV protease inhibitor telaprevir. She recalls that a major challenge for the HCV antivirals was that scientists didn’t know where in the body the virus was hiding. Kwong says she had to fight to develop an antiviral that targeted the liver since it hadn’t yet been confirmed that HCV primarily resides there. People with chronic hepatitis C would in many cases eventually develop liver failure or cancer, but they presented with other issues too, like brain fog, fatigue, and inflammation.

She sees the same dynamic playing out in long COVID.

“This reminds me of HIV days and HCV days,” Kwong says. “This idea that pharma doesn’t want to work on this because we don’t know things about SARS-CoV-2 and long COVID is bullshit.”

Since January, Kwong has been cooking up something new. She’s approaching long COVID the way she did chronic hepatitis C: treating it as a chronic infection, through a start-up called Persistence Bio. Persistence is still in stealth; its name reflects its mission to create antivirals that can reach hidden reservoirs of persistent SARS-CoV-2, which many researchers believe to be a cause of long COVID.

“Long COVID is really interesting because there’s so many different symptoms,” Kwong says. “As a virologist, I am not surprised, because it’s an amazing virus. It infects every tissue in your body. . . . All the autopsy studies show that it’s in your brain. It’s in your gut. It’s in your lungs. It’s in your heart. To me, all the different symptoms are indicative of where the virus has gone when it infected you.”

Kwong has experienced some of these symptoms firsthand. She contracted COVID-19 while flying home to Massachusetts from Germany in 2020. For about a year afterward, she’d get caught off guard by sudden bouts of fatigue, bending over to catch her breath as she walked around the horse farm where she lives, her legs aching. Those symptoms went away with time and luck, but another round of symptoms roared to life this spring, including what Kwong describes as “partial blackouts.”

Kwong hasn’t been formally diagnosed with long COVID, but she says she “strongly suspects” she has it. Others among Persistence’s team of about 25 also have the condition.

“Long COVID patients have been involved with the founding of our company, and we work closely with them and know how awful the condition can be,” Kwong says. “It is a big motivator for our team.”

Persistence is in the process of fundraising. Kwong says she’s in conversations with private investors, but she and her cofounders are hoping to get public funding too.

On Sept. 23, the NIH is convening a 3-day workshop to review what RECOVER has accomplished and plan the next phase of the initiative. Crucially, that phase will include additional clinical trials. RECOVER’s $1.7 billion in funding includes a recent award of $515 million over the next 4 years. It’s not out of the question that this time, industry players might be invited to the table. Tonix Pharmaceuticals’ Lederman and Aim ImmunoTech’s McAleer will both speak during the workshop.

The US Senate Committee on Appropriations explicitly directed the NIH during an Aug. 1 meeting to prioritize research to understand, diagnose, and treat long COVID. It also recommended that Congress put $1.5 billion toward the Advanced Research Projects Agency for Health (ARPA-H), which often partners with industry players. The committee instructed ARPA-H to invest in “high-risk, high-reward research . . . focused on drug trials, development of biomarkers, and research that includes long COVID associated conditions.” Also last month, Sen. Bernie Sanders (I-VT) introduced the Long COVID Research Moonshot Act, which would give the NIH $1 billion a year for a decade to treat and monitor patients.

It’s these kinds of mechanisms that might make a difference for long COVID drug development.

“What I’ve seen a lot is pharma being hesitant to get involved,” says Lisa McCorkell, a cofounder of the PLRC and a coauthor of the recent long COVID review. “Maybe they’ll invest if NIH also matches their investment or something like that. Having those public-private partnerships is really, at this stage, what will propel us forward.”

Chemical & Engineering News ISSN 0009-2347 Copyright © 2024 American Chemical Society

[nasa]

What is Artemis I?

On November 14, NASA is set to launch the uncrewed Artemis I flight test to the Moon and back. Artemis I is the first integrated flight test of the Space Launch System (SLS) rocket, the Orion spacecraft, and Exploration Ground Systems at NASA’s Kennedy Space Center in Florida. These are the same systems that will bring future Artemis astronauts to the Moon.

Standing 322 feet (98 meters) tall, the SLS rocket comprises of a core stage, an upper stage, two solid boosters, and four RS-25 engines. The SLS rocket is the most powerful rocket in the world, able to carry 59,500 pounds (27 metric tons) of payloads to deep space — more than any other vehicle. With its unprecedented power, SLS is the only rocket that can send the Orion spacecraft, astronauts, and cargo directly to the Moon on a single mission.

Before launch, Artemis I has some big help: the Vehicle Assembly Building (VAB) at KSC is the largest single-story building in the world. The VAB was constructed for the assembly of the Apollo/Saturn V Moon rocket, and this is where the SLS rocket is assembled, maintained, and integrated with the Orion spacecraft. 

The mobile launcher is used to assemble, process, and launch the SLS rocket and Orion spacecraft. The massive structure consists of a two-story base and a tower equipped with a number of connection lines to provide the rocket and spacecraft with power, communications, coolant, and fuel prior to launch.

Capable of carrying 18 million pounds (8.2 million kg) and the size of a baseball infield, crawler-transporter 2 will transport SLS and Orion the 4.2 miles (6.8 km) to Launch Pad 39B. This historic launch pad was where the Apollo 10 mission lifted off from on May 18, 1969, to rehearse the first Moon landing.

During the launch, SLS will generate around 8.8 million pounds (~4.0 million kg) of thrust, propelling the Orion spacecraft into Earth’s orbit. Then, Orion will perform a Trans Lunar Injection to begin the path to the Moon. The spacecraft will orbit the Moon, traveling 40,000 miles beyond the far side of the Moon — farther than any human-rated spacecraft has ever flown.

The Orion spacecraft is designed to carry astronauts on deep space missions farther than ever before. Orion contains the habitable volume of about two minivans, enough living space for four people for up to 21 days. Future astronauts will be able to prepare food, exercise, and yes, have a bathroom. Orion also has a launch abort system to keep astronauts safe if an emergency happens during launch, and a European-built service module that fuels and propels the spacecraft.

While the Artemis I flight test is uncrewed, the Orion spacecraft will not be empty: there will be three manikins aboard the vehicle. Commander Moonikin Campos will be sitting in the commander’s seat, collecting data on the vibrations and accelerations future astronauts will experience on the journey to the Moon. He is joined with two phantom torsos, Helga and Zohar, in a partnership with the German Aerospace Center and Israeli Space Agency to test a radiation protection vest.

A host of shoebox-sized satellites called CubeSats help enable science and technology experiments that could enhance our understanding of deep space travel and the Moon while providing critical information for future Artemis missions.

At the end of the four-week mission, the Orion spacecraft will return to Earth. Orion will travel at 25,000 mph (40,000 km per hour) before slowing down to 300 mph (480 km per hour) once it enters the Earth’s atmosphere. After the parachutes deploy, the spacecraft will glide in at approximately 20 mph (32 km per hour) before splashdown about 60 miles (100 km) off the coast of California. NASA’s recovery team and the U.S. Navy will retrieve the Orion spacecraft from the Pacific Ocean.

With the ultimate goal of establishing a long-term presence on the Moon, Artemis I is a critical step as NASA prepares to send humans to Mars and beyond.

Make sure to follow us on Tumblr for your regular dose of space!

[rjzimmerman]

How many of you get excited when you see a monarch butterfly? If you do, did you get excited as a kid, or is the excitement a function of their possibly pending extinction? If you do not, can you imagine a world without monarch butterflies?

Excerpt from this story from E&E News/Politico:

Judgment day approaches for the monarch butterfly.

Bound by a court settlement, the Fish and Wildlife Service is supposed to decide by early December whether the monarch warrants listing as threatened or endangered. Although the agency misses many Endangered Species Act deadlines, it appears determined to meet this one after several years of study.

“We wanted to make sure that we have all the best science available … and we wanted to make sure that we were able to gather all that information and make a quality decision,” said Nicole Alt, director of FWS’ Center for Pollinator Conservation.

With the migratory butterfly passing through dozens of states, a decision to list the species could be accompanied by the designation of an expansive critical habitat. Combined with other regulatory implications, this could make the long-delayed monarch listing call one of the most consequential actions in the history of the ESA. It also appears likely, some monarch experts say, given the bleak population trends that led FWS to conclude in 2020 that “monarch viability is declining and is projected to continue declining over the next 60 years.”

Despite the dire circumstances, a campaign to help the monarch butterfly has been advancing on multiple fronts but without a unified commander in chief. Rather, the monarch’s allies march under different flags that reflect a dispersed approach toward species conservation. Some study the insect, some set aside habitat and some tinker with new tools, all without reference to a species recovery plan that an ESA listing would mandate.

Consider:

From an urban office building, a program administered by the University of Illinois, Chicago’s Energy Resources Center has recruited energy companies, state departments of transportation and counties into conserving hundreds of thousands of acres as butterfly habitat on rights of way, such as the medians between roads.

On sprawling Fort Cavazos — formerly Fort Hood — in Texas, biologists prowl the grounds in search of adult monarchs as well as eggs and larva. Since 2017, they estimate they have collected information from more than 10,000 tagged adult monarchs and forwarded this data to another team of collaborators with the Monarch Watch program based at the University of Kansas.

From her Denver office, Alt oversees four geographically scattered FWS staffers and collaborates with others in and out of government. With yet another allied group called Monarch Joint Venture, for instance, the Center for Pollinator Conservation is supporting studies of drones and artificial intelligence in measuring milkweed distribution on wildlife refuges.

And, scattered as they are, the various monarch teams, researchers and advocates periodically gather for a meeting of the minds, as they did in the summer of 2022 for a first-of-its-kind Capitol Hill butterfly summit where Interior Secretary Deb Haaland announced establishment of Alt’s pollinator center.

“It’s really been exciting to see the level of interest from lots of different sectors,” Alt said, adding that “different people want to work in different ways and in different spaces … and in the vast majority of situations they are all advocating for the same thing.”

Some conservation groups, however, want to see a more urgent focus on the problem, saying Congress needs to dramatically increase funding to help the monarchs truly recover. In letters sent last week to House and Senate appropriators, the Center for Biological Diversity and other environmental groups called on lawmakers to provide $100 million annually to restore 1 million acres of pollinator habitat in this country each year and another $30 million to preserve forests in Mexico where some of the butterflies spend their winters.

The groups noted how people over generations have heralded the black-and-orange butterfly’s “spectacular beauty and epic, life-affirming migrations.”

“Dedicating $100 million a year to monarch conservation gives these beloved butterflies a fighting chance at survival,” one letter said.

[todaysdocument]

This edition of the Marshall Star from 1973, a newsletter of the George C. Marshall Space Center in Huntsville, Alabama, features an article titled “Anita, Job Done, Dies Aboard Skylab.” 

The article goes on to explain that Anita was the back-up spider in the Web Formation Experiment.  The primary spider, Arabella, was still alive at the time of the newsletter. Arabella’s current whereabouts are unknown.

Record Group 255: Records of the National Aeronautics and Space AdministrationSeries: Marshall StarFile Unit: Marshall Star Volume 14

Marshall Star Vol. 14, No. 2 . NASA George C. Marshall Space Flight Center -- Huntsville, Ala. 35812 . September, 1973 Final EVA Saturday Skylab 3 Crew Prepares For Next Week's 'Splash' Skylab's second manned crew, prvoding a bonanza of scientific data to investigators on Earth. has begun preparations for splashdown and recovery scheduled for Tuesday, Sept. 25. As they head into the home stretch, Astronauts Alan Bean, Owen Garriott and Jack Lousma are operating ahead of experiment timelines. Flight directors estimate they will exceed 100 percent of their planned activity in all scientific disciplines. The crew is scheduled to conduct its third and final EVA Saturday. Exposed film cannisters will be removed from the Apollo Telescope Mount's instruments for stowage inside the Command and Service Module and return to Earth. For the EVA, the crew is to awaken at 2 a.m. Hatch opening is expected about four hours later. Monday the crew becan changing the rhythm of their sleep-work cycle by arising at 4 a.m. after goint to bed two hours early. This schedule was to be followed Tuesday. Today the crew planned to arise at 2 a.m. after beginning their sleep period at 6 p.m. last night. Purpose of the new sleep-work cycle is to prepare the astronauts for splashdown day when they will be required to arise early for a full day's activity. The crew was given the go- ahead last week for continuation to the end of the 59-day mission. This approval for a fourth incremental extension beyond 28 days followed review of the inflight medical data and the recommendation of the NASA director for life sciences, Dr. Charles A. Berry. The crew's health and spirits are excellent. The body weight of each has been relatively constant (See SKYLAB on Page 4) SOLAR ERUPTION -- A mammoth solar eruption is seen in this photo taken by the White Light Coronagraph about Sklyab. The eruption expanded into space at a speed of about one million miles per hour. When photographed it was approximately 220 times the diameter of Earth. Solar eruptions are a result of the interaction between solar material and magnetic fields around the Sun. Combined Federal Campaign 'Kickoff' Scheduled Monday MSFC's 1974 Combined Federal Campaign gets underway Monday with a "kickoff" in Morris Auditorium. The annual campaign combines the monetary needs of many health, welfare and recreational agencies into one drive. Rober G. Sheppard, executive chairman, stated the drive officially begins with the 10:45 a.m. kickoff and will end November 2. He explained that the 1974 goal is to do as well as in 1973 when MSFC employees contributed $194,712. Monday's kickoff ceremonies will feature and address by Dr. Rocco A. Petrone, director. He will be joined by several distinguished guests, including Mrs. Ruth Ferrari, International Services Agencies; Tom Horton, Jr., National Health Agencies; and Mrs. Jerri McLain, Huntsville/ Madison County United Way. MSFC lab and office directors, campaign mangers and solicitors are expected to attend the opening ceremonies. Music will be provided by the 55th U.S. Army Band. The Rev. Hugh Chambliss, presi- (See 'KICKOFF' on Page 4) 

Anita, Job Done, Dies Aboard Skylab One of Skylab's two "spider astronauts" --who never were intended to be brought back to Earth--has now finished her job in space and is dead. Anita, the backup spider for the Web Formation Experiment, ED52, apparently died sometime over the weekend. The report of Anita's death came from science pilot Owen Garriott early Monday. Although NASA had no plans to bring back the spiders, it was announced several weeks ago that they would be returned if they could be kept alive. Arabella, the prime spider for the experiment, is still doing fine. Garriott explained from the (See ANITA on Page 4)

[beatrice-otter]

The tribes, environmentalists and their allies celebrated the shrinking waters as an essential next step in what they say will be a decades-long process of restoring one of the West's largest salmon fisheries and a region the size of West Virginia back to health. Yurok tribal member and fisheries director Barry McCovey was amazed at how fast the river and the lands surrounding the Copco dam were revealed. "The river had already found its path and reclaimed its original riverbed, which is pretty amazing to see," he said. The 6,500-member tribe's lands span the Klamath's final 44 miles to the Pacific Ocean, and the Yurok and other tribes that depend on the Klamath for subsistence and cultural activities have long advocated for the dams' removal and for ecological restoration. Amid the largest-ever dam removal in the U.S., rumors and misunderstandings have spread through social media, in grange halls and in local establishments. In the meantime, public agencies and private firms race to correct misinformation by providing facts and real data on how the Klamath is recovering from what one official called "major heart surgery." But while dam removal continues, a coalition of tribes, upper Klamath Basin farmers, and the Biden administration have struck a new deal to restore the Klamath Basin and improve water supplies for birds, fish and farmers alike. ...

The Yurok Tribe also contracted with Resource Environmental Solutions to collect the billions of seeds from native plants needed to restore the denuded lands revealed when the waters subsided. The company, known to locals as RES, took a whole-ecological approach while planning the project. In addition to rehabbing about 2,200 acres of land exposed after the four shallow reservoirs finish draining, "we have obligations for a number of species, including eagles and Western pond turtles," said David Coffman, RES' Northern California and Southern Oregon director. ... The company also plans to support important pollinators like native bumblebees and monarch butterflies and protect species of special concern like the willow flycatcher. And, Coffman said, removal of invasive plant species like star thistle is also underway. In some cases, he said, workers will pull any invasives out by hand if they notice them encroaching on newly planted areas. ...

The Interior Department announced Wednesday that the agency had signed a deal with the Yurok, Karuk and Klamath Tribes and the Klamath Basin Water Users Association to collaborate on Klamath Basin restoration and improving water reliability for the Klamath Project, a federal irrigation and agricultural project. An Interior Department spokesperson said the agency had been meeting with river tribes and the farmers of the Upper Basin for the first time in a decade to develop a plan to restore basin health, support fish and wildlife in the region, and support agriculture in the Upper Basin. "We're trying to make it as healthy as possible and restore things like wetlands, natural stream channels and forested watershed," the spokesperson said. He likened it to keeping the "sponge" wetlands provide to store water wet. The effort is meant to be a cross-agency and cross-state process. The Biden administration also announced $72 million in funding for ecosystem restoration and agricultural infrastructure modernization throughout the Klamath Basin from the Bipartisan Infrastructure Act.  

[dataplusrecovery]

DATAPLUS - #1 Data Recovery Agency

Any EFS-encrypted file can be decrypted and read by an administrative account using the data recovery agent. An X.509 certificate has been provisioned into the DRA account. Every EFS file is encrypted with a second protector that the DRA certificate can unlock. As a result, both the DRA and its certificate are extremely delicate. Protect it and only use it when absolutely necessary. The DRA should not be used as a typical account or frequently by administrators.

An individual File Encryption Key (FEK) is encrypted into each EFS-encrypted file. The FEK is made in two separate copies when a DRA is assigned: The user public certificate encrypts one, while the DRA public certificate encrypts the other. The encrypted file contains both encrypted FEKs. This enables the DRA to recover the file even if the user’s encryption certificate is lost, allowing both the user and DRA to decrypt the file independently.

While maintaining DRA access, an administrator can also deny users access to the encrypted file. Because only one recovery certificate that can access each file needs to be stored, the amount of information that is saved is reduced.

Imagine an office building with a lot of offices and key locks on the doors to show how a DRA works. For the purposes of this illustration, each employee (user) must be able to unlock their office door. They may have multiple offices. Additionally, DRA maintenance personnel must be able to unlock each door. In this scenario, maintenance personnel would require a copy of each key, and each employee would require a key for the one or more doors they must unlock. The number of keys being used would quickly increase as a result of this.

Installing two copies of the door-unlocking key (FEK) in a lockbox next to the door they unlock is one way to address this issue. The lock box can be opened with the key held by both the worker and the maintenance person. In this manner, each individual only requires a single key to open any accessible door. Only the key boxes need to be changed to update access.

The DRA was designed to be used in a business setting. It is based on a Microsoft Windows policy framework like Microsoft Endpoint Configuration Manager, Microsoft Intune, or Microsoft Active Directory Group Policy.

The generation of a Data Recovery Agency key (DRA key) is the first step in the process of creating a DRA. The recovery key will come from this certificate, which contains a pair of public and private keys. The Windows executable cipher can be used to generate it. [Run the order “figure/r: FILENAME” to produce files with the extensions.cer and.pfx.] A public key infrastructure (PKI) can also be used to generate the certificate.

The user must open the Group Policy Object Editor and navigate to ConfigurationWindowsSettingsSecuritySettingsPublic Key Policies. Encrypting File System, right-click on Encrypting File System in the right-hand pane, and select Create Data Recovery Agency to deploy a DRA using Microsoft Active Directory Group Policy. Using the pre-generated certificate or a user account with a published certificate from Active Directory will launch a wizard for adding the DRA to the domain.

The user must create a configuration item in the configuration item’s node in Microsoft System Center Configuration Manager (SCCM) and select Windows Information Protection for the device settings to configure in order to deploy a DRA for WIP using Microsoft Endpoint Configuration Manager. The WIP policy is then created using the wizard. “Upload a Data Recovery Agent (DRA) certificate to allow recovery of encrypted data” is the first step in the setup wizard, where the user can browse to select the created Data Recovery Agency certificate.

[accountabilityza]

Managing Cash Flow: The Role of Debt Collection Services in South Africa for Business

Cash flow is essential to any business, ensuring that operations run smoothly, and expenses are covered. Late or unpaid invoices, on the other hand, can have a significant impact on cash flow, causing financial difficulties and jeopardising a company's viability. Debt collection services in South Africa play a key role in assisting businesses in recovering outstanding debts and maintaining a steady cash flow.

One of the primary functions of debt collection services in South Africa is to serve as a liaison between businesses and debtors. These services focus on negotiating payment terms and agreements that benefit both parties. Debt collection services, by facilitating communication and negotiation, can assist businesses in recovering outstanding debts while maintaining positive client relationships.

In addition to negotiating payment terms, debt collection services in South Africa use a variety of strategies to recover debts. These strategies may include sending reminders and notices to debtors, making follow-up calls, and, if necessary, taking legal action. Debt collection services can increase the likelihood of collecting outstanding debts on time by leveraging their expertise and resources.

Furthermore, debt collection services in South Africa play a key role in reducing the risk of severe debt. By proactively managing and monitoring outstanding invoices, these services can detect potential problems early on and take appropriate action to avoid severe debt. This initiative-taking approach can help businesses maintain positive cash flow and avoid financial losses.

Another important feature of debt collection services in South Africa is their ability to provide businesses with valuable insights and analytics. These services can assist businesses in optimising their credit management processes and lowering the risk of future overdue payments by analysing patterns of payment and debtor behaviour. This data-driven approach may eventually lead to increased cash flow and financial stability for businesses.

Debt collection services in South Africa are also essential for helping businesses during tough economic times. In times of economic uncertainty or downturn, businesses may see an increase in overdue payments and unpaid invoices. Debt collection services can be extremely beneficial during these times, assisting businesses in recovering outstanding debts and maintaining cash flow stability.

Furthermore, debt collection services in South Africa can help businesses recover debts from difficult or unwilling debtors. Dealing with difficult debtors can be time-consuming and frustrating for businesses, especially when juggling other operational responsibilities. Debt collection services have the knowledge and resources to manage these situations professionally and efficiently, allowing businesses to focus on their core operations.

Debt collection services in South Africa can help businesses avoid legal action. When debtors refuse to pay or disputes arise, debt collection services can assist businesses in navigating the legal system and effectively resolving issues. This can help businesses save time and money on legal proceedings while also ensuring that debts are recovered as soon as possible.

Finally, debt collection services are critical to managing cash flow and ensuring the financial health of South African businesses. These services help businesses recover outstanding debts, reduce severe debt, and maintain healthy cash flow by acting as mediators, implementing effective recovery strategies, and providing valuable insights. As a result, businesses in South Africa can benefit significantly from collaborating with reputable debt collection agencies to efficiently manage their receivables.

[plethoraworldatlas]

Wildlife Services, a program of the U.S. Department of Agriculture, has released a new set of standards it will use to determine the cause of livestock deaths in Arizona and New Mexico. Conservation groups have sought such changes to ensure Mexican gray wolves aren’t unfairly blamed for livestock deaths.The new standards require evidence, such as subcutaneous hemorrhaging, that the livestock animal was alive during the wolf encounter, and additional indicators of wolf involvement.

“Our goal has been to make sure that Mexican gray wolves aren’t being unfairly blamed for livestock depredation,” said Greta Anderson, deputy director of Western Watersheds Project. “The over-reported incidence of wolf involvement in cattle deaths in the Southwest has had negative impacts on the wolf recovery program, including the killing and capture of wild wolves. We’re hoping the new standards help prevent that from happening again.”

Today’s action follows an exposé of Wildlife Services’ unscientific and unsupportable reports, in which a former state director of the agency called out what he saw as corruption in the livestock deaths reporting program. A Western Watersheds Project review of five years of predation reports highlighted poor data collection, illogical conclusions, and an unjustifiably high rate of blaming wolves for the deaths of livestock on public lands.

“It’s appalling that the U.S. Department of Agriculture blames endangered Mexican gray wolves for killing cows that died of something completely different,” said Michael Robinson, a senior conservation advocate at the Center for Biological Diversity. “I’m glad they’re tightening standards for determining the causes of cattle mortality, but the government should go further and require that ranchers properly dispose of dead cattle to protect both wolves and livestock.”

[rambleonwaywardson]

Astronaut AU Definitions

Since we're getting into more mission oriented chapters and I'm not sure how technical things will get, a definition post that I will link on future chapters and add to as needed:

Flight Controllers: CAPCOM: Capsule communicator; direct line of contact between astronauts and mission control

CDH: Command and Data Handling Officer; manages computer systems, software, data, and display interfaces on Orion

EECOM: Emergency, Environmental, and Consumables Officer; monitors environmental controls, life support systems, and emergency procedures in Orion

FAO: Flight Activities Officer; manages and coordinates the flight plan to meet mission objectives, including timeline of all crew activities

FIDO: Flight Dynamics Officer; monitors the trajectory of Orion through the entire mission

Flight: The flight director; oversees all mission control activity

GNC: Guidance, Navigation, and Control Officer; operates and monitors navigation and flight control software on Orion

INCO: Integrated Communications Officer; monitors Orion's communication systems (data, telemetry, and video)

MPO: Mechanical and Power Officer; monitors electrical, mechanical, structural, and landing/recovery systems on Orion including batteries, solar arrays, thermal protection, etc.

PAO: Public Affairs Officer (Marge!); provides mission commentary, explains the mission and flight control operations to the public/media, and coordinates events between the media and crew/mission control

Prop: Propulsion Officer; monitors Orion's propulsion systems, engine burns, position control maneuvers

General Space Program/Mission Terminology: AGS: abort guidance system

ESA: European Space Agency

ESL: Earth Landing System - jettisons the crew capsule heat shield and releases the parachutes during re-entry into Earth’s atmosphere

EVA: Extravehicular activity (spacewalks and moonwalks)

ISS: International Space Station

JSC: Johnson Space Center in Houston TX

KSC: Kennedy Space Center in Cape Canaveral, FL

Neutral Buoyancy Tank: Giant water tank at JSC used to simulate working in zero gravity

OCS suits: Orion Crew Survival suits; the space suits worn inside the spacecraft during critical mission phases and in an emergency situation

Launch and Other Spacecraft Terminology: APU: Auxiliary Power Unit; provides power/electricity to the spacecraft

Feet Wet: Navy and Air Force speak for being over water

“G” or Gs: the force of gravity (7 Gs is 7 times the force of gravity on Earth)

GLS: Ground Launch Sequencer; automated system that controls the countdown from about T-10 minutes on. Starting at this point, 'T-' is used instead of 'L-'

H-dot: the time derivative of height (the ascent rate of a space vehicle) during launch

ICPU: Interim Cryogenic Propulsion Stage; another stage of the SLS with more engines that are used to reorient the spacecraft after core stage separation

LEO: Low Earth Orbit

LLO: Low Lunar Orbit

Max q: maximum dynamic pressure on the rocket due to pushing through the thickest part of the atmosphere at high speeds

MECO: Main Engine Cut Off (literally cutting off the main engine)

NRHO: Near-Rectilinear Halo Orbit; the orbit that Orion will be in around the moon, balanced between the moon's gravity and the Earth's gravity; spacecraft in constant contact with and view of Earth

PGNS: pronounced “pings,” Primary Navigation and Guidance System

RRT: Re-entry interface - the moment the capsule re-enters Earth’s atmosphere

SRB: Solid Rocket Booster; solid propellant motors providing additional thrust (there are two on the sides of SLS)

TLI: Trans-Lunar Injection burn; firing the engines to get the spacecraft on a path towards the moon

[hellomynameisbisexual]

Bisexual survivors, like all survivors of any form of trauma or violence, deserve compassion, support, and better treatment. Bisexual individuals who have experienced trauma or violence may face unique challenges and forms of discrimination that require specific attention and understanding. Here are some key aspects of why bisexual survivors deserve better:

Visibility and Recognition: Bisexual survivors' experiences are often overlooked or erased, both within the LGBTQ+ community and in broader society. Their experiences might not fit neatly into heteronormative or monosexist narratives, leading to further marginalization and lack of support.

Biphobia and Stigma: Bisexual survivors may face biphobia and stigma, even from within the LGBTQ+ community, which can compound the trauma they have experienced. This additional layer of discrimination can create barriers to seeking help and support.

Access to Support Services: Support services for survivors of trauma are essential, but they may not always be inclusive and sensitive to the unique needs of bisexual individuals. Efforts should be made to ensure that support services are affirming and accommodating for all sexual orientations and gender identities.

Cultural Competency and Training: Service providers, including therapists, counselors, and law enforcement professionals, should receive training on bisexuality and the specific issues faced by bisexual individuals. This training helps them better understand and support bisexual survivors effectively.

Intersectionality: Many bisexual individuals have intersecting identities, such as race, ethnicity, gender identity, and socioeconomic status. Intersectionality must be considered when providing support and resources to address the diverse needs of bisexual survivors.

Fostering Safe Spaces: Creating safe and inclusive spaces where bisexual survivors can share their experiences and find support is crucial. This includes both physical spaces and virtual communities.

Breaking the Silence: Encouraging open conversations about bisexual survivorship can help break the silence surrounding their experiences and raise awareness about their unique needs and challenges.

Empowerment and Agency: Providing resources that empower bisexual survivors to reclaim their agency and voice in the aftermath of trauma is essential for healing and recovery.

Research and Data Collection: More research should be conducted on the experiences of bisexual survivors to better understand their needs and develop targeted interventions and support services.

Addressing Bi-Erasure in Support Discourses: Efforts should be made to address and challenge bi-erasure in discussions surrounding trauma and survivorship, ensuring that bisexual individuals' experiences are acknowledged and validated.

Overall, addressing the specific needs of bisexual survivors requires a comprehensive approach that involves education, awareness, policy changes, and a commitment to inclusivity within support systems and communities. By advocating for better treatment and support for bisexual survivors, we can work towards a more just and equitable society for all survivors of trauma and violence.

[covid-safer-hotties]

Long COVID is a $1 trillion problem with no cure. Experts plead for governments to wake up - Published Aug 9, 2024

For months, governmental officials around the world have appeared to want to forgo discussing the specter of long COVID. As a new review makes clear, that is wishful thinking—and the latest COVID variants may well kick long COVID into overdrive, a scenario that researchers and experts have been warning about for some time.

“I think they (government agencies) are itching to pretend that COVID is over and that long COVID does not exist,” says Ziyad Al-Aly, director of the Clinical Epidemiology Center at Veterans Affairs St. Louis Health Care System and lead author of the review. “It is much more pleasant to pretend as if emergency department visits and hospitalizations haven’t been rising sharply this summer.”

In a Nature Medicine review this week, Al-Aly and several other top researchers lay out a difficult truth: Long COVID has already affected an estimated 400 million people worldwide, a number the authors say is likely conservative, at an economic cost of about $1 trillion annually—equivalent to 1% of the global economy.

Moreover, the risk of a person being hit with long COVID rises with repeated infections of the virus itself, and recent COVID activity has experts watching closely. As review co-author Eric Topol noted in a recent blog post, the current COVID incursion is ramping up quickly, with one modeler estimating 900,000 new infections per day in the U.S. alone.

“The new significant wave,” Topol said via X. “It’s hard to believe the we are well into our fifth year of this virus and not taking the requisite steps to gain control.”

The virus is evolving incessantly. Multiple COVID subvariants, collectively nicknamed FLiRT, are powerfully present in the U.S., and reports from California indicate that some patients are complaining of throat pain so strong it feels like they’re “swallowing razors or broken glass,” according to the Los Angeles Times. Topol, meanwhile, says the Sato Lab in Japan has characterized one of the newest COVID strains, KP.3.1.1, in a preprint as having “the most immune evasion and infectivity of any of the variants” derived from previous powerful iterations of the JN.1 strain, which was prominent last winter.

Although the Centers for Disease Control and Prevention says that severe outcomes and deaths from COVID have decreased substantially overall from the pandemic’s early days, wastewater data shows viral activity is “high’ nationally and COVID-19 infections are growing or likely growing in 35 states. More COVID infections mean more cases of long COVID. And long COVID is already exacting an enormous toll on both the people and economies of the world.

Those are words you aren’t hearing from many government bodies. But, the researchers say, the evidence tells the story.

“Despite the dire impact of long COVID on individuals and society, I fear that many are still unaware of the danger,” says Akiko Iwasaki, professor of immunology at Yale School of Medicine and co-lead investigator of the university’s COVID-19 Recovery Study. “There is an urgent need to provide proper diagnosis and treatment for people living with long COVID.”

Read the full report at either link! (covidsafehotties is always free of annoying in-line ads, jsyk!)