#Endocrinology Research

[academicstrive]

🚀 Unlock the Future of Endocrinology Research with JATER! 🚀

AcademicStrive #Endocrinology #Research #JATER #PublishNow

Are you a researcher with groundbreaking insights into the endocrine system? 🧬🌟 We invite you to contribute to the Journal of Advanced Technologies in Endocrinology Research (JATER), a premier open-access journal dedicated to exploring the complexities of hormone-related phenomena.

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[religion-is-a-mental-illness]

We have a serious problem

Michael Laidlaw, MD: I'm a board-certified endocrinologist, practicing in private practice for the last 16 years. I've been studying and publishing in this area for the last 5 years, including peer reviewed journals such as Journal of of Clinical Endocrinology and Metabolism, and others. I also have a patient who is a detransitioner.

I think it's important to note that studies are shown that desistance, or growing out of this condition, of children by adulthood is very high. It's some 50-98%.

I want to be sure before I give someone a very powerful hormone like Insulin that they in fact have diabetes.

What about cancer? Before we give any powerful agents such as chemotherapeutics or surgeries, we certainly want to have physical evidence of this problem, such as biopsies or imaging.

Now, the gender affirmative therapy treatment proposed by WPATH gives very powerful hormones and surgeries on what basis? Where can we find the gender identity to be certain that these children will not desist by adulthood? Can we use imaging of the brain or blood tests, genetic testing, are there other biomarkers to ensure that we are correct? There is no such thing.

Julia Mason, MD: The Endocrine Society put out guidelines in 2017, and they were very careful in the guidelines. One, to point out that the evidence was of low and very low quality. And they also said in the guidelines that they have no idea how you identify which kids are trans and require this treatment.

And then the American Academy of Pediatrics the next year just leapt into that void and said, oh, oh, we'll tell you how you know which kids. You ask them.

Prior to 2018 I had maybe one trans patient. But then there was another one. And another one. And another one.

It wasn't until later that I started asking questions like, wait, every single kid I send to the gender clinic gets put on puberty blockers or cross-sex hormones. Just, it was happening immediately.

Patrick Hunter, MD: This affirmative model of care has spread wildly in the last 8 years. Now we have objective, unbiased systematic reviews. These systematic reviews tell us the evidence for youth transition is poor quality, and with very low certainty for benefit.

In JAMA Pediatrics, there was a study reported from Northwestern University in Chicago. Patients ranged in age from 13 to 24 years. The authors concluded that mastectomy was beneficial and should not be delayed in youth. What lead them to that conclusion? The finding that 3 months after surgery, the 36 patients were happy with their flat chests. They lost 9% of their surgical cases to follow-up. Nine percent. In 3 months.

It is absurd, meaningless to draw any conclusions after 3 months.

This paper is indicative of the quality of research we have in this field, published in our most prestigious journals.

We have a serious problem.

[5thdivinebeast]

Cis people talking about Trans Healthcare is honestly so bizarre.

Like they'll be like "we have to ban hormone blockers for children" not realizing hormone blockers were developed for children who entered puberty too early back in the 70s and, with proper medical consultation, there are no known lasting side effects.

Like they are fully willing to sacrifice the health of cis kids because they never bothered to see of their warped view of the Trans experience had any factual basis

[reasonsforhope]

"The first modern attempt at transferring a uterus from one human to another occurred at the turn of the millennium. But surgeons had to remove the organ, which had become necrotic, 99 days later. The first successful transplant was performed in 2011 — but even then, the recipient wasn’t immediately able to get pregnant and deliver a baby. It took three more years for the first person in the world with a transplanted uterus to give birth. 

More than 70 such babies have been born globally in the decade since. “It’s a complete new world,” said Giuliano Testa, chief of abdominal transplant at Baylor University Medical Center.

Almost a third of those babies — 22 and counting — have been born in Dallas at Baylor. On Thursday, Testa and his team published a major cohort study in JAMA analyzing the results from the program’s first 20 patients. All women were of reproductive age and had no uterus (most having been born without one), but had at least one functioning ovary. Most of the uteri came from living donors, but two came from deceased donors.

Fourteen women had successful transplants, all of whom were able to have at least one baby.  

“That success rate is extraordinary, and I want that to get out there,” said Liza Johannesson, the medical director of uterus transplants at Baylor, who works with Testa and co-authored the study. “We want this to be an option for all women out there that need it.”

Six patients had transplant failures, all within two weeks of the procedure. Part of the problem may have been a learning curve: The study initially included only 10 patients, and five of the six with failed transplants were in that first group. These were “technical” failures, Testa said, involving aspects of the surgery such as how surgeons connected the organ’s blood vessels, what material was used for sutures, and selecting a uterus that would work well in a transplant. 

The team saw only one transplant fail in the second group of 10 people, the researchers said. All 20 transplants took place between September 2016 and August 2019.

Only one other cohort study has previously been published on uterus transplants, in 2022. A Swedish team, which included Johannesson before she moved to Baylor, performed seven successful transplants out of nine attempts. Six women, including the first transplant recipient to ever deliver a baby back in 2014, gave birth.

“It’s hard to extract data from that, because they were the first ones that did it,” Johannesson said. “This is the first time we can actually see the safety and efficacy of this procedure properly.”

So far, the signs are good: High success rates for transplants and live births, safe and healthy children so far, and early signs that immunosuppressants — typically given to transplant recipients so their bodies don’t reject the new organ — may not cause long-term harm, the researchers said. (The uterine transplants are removed after recipients no longer need them to deliver children.) And the Baylor team has figured out how to identify the right uterus for transfer: It should be from a donor who has had a baby before, is premenopausal, and, of course, who matches the blood type of the recipient, Testa said...

“They’ve really embraced the idea of practicing improvement as you go along, to understand how to make this safer or more effective. And that’s reflected in the results,” said Jessica Walter, an assistant professor of reproductive endocrinology and infertility at Northwestern University Feinberg School of Medicine, who co-authored an editorial on the research in JAMA...

Walter was a skeptic herself when she first learned about uterine transplants. The procedure seemed invasive and complicated. But she did her fellowship training at Penn Medicine, home to one of just four programs in the U.S. doing uterine transplants. 

“The firsts — the first time the patient received a transplant, the first time she got her period after the transplant, the positive pregnancy test,” Walter said. “Immersing myself in the science, the patients, the practitioners, and researchers — it really changed my opinion that this is science, and this is an innovation like anything else.” ...

Many transgender women are hopeful that uterine transplants might someday be available for them, but it’s likely a far-off possibility. Scientists need to rewind and do animal studies on how a uterus might fare in a different “hormonal milieu” before doing any clinical trials of the procedure with trans people, Wagner said.

Among cisgender women, more long-term research is still needed on the donors, recipients, and the children they have, experts said.

“We want other centers to start up,” Johannesson said. “Our main goal is to publish all of our data, as much as we can.”"

-via Stat, August 16, 2024

[covenawhite66]

A study with prairie voles bred without receptors for oxytocin and showed the same monogamous mating, attachment, and parenting behaviors as regular voles. In addition, females without oxytocin receptors gave birth and produced milk, though in smaller quantities, than ordinary female voles.

Challenging studies in the 1990s using drugs that prevent oxytocin from binding to its receptor found that voles were unable to pair bond, giving rise to the idea that the hormone is essential to forming such attachments.

Prairie voles are among a small group of mammals that display long-term social attachment between mating partners. Many pharmacological studies show that signaling via the oxytocin receptor (Oxtr) is critical for the display of social monogamy in these animals. We used CRISPR mutagenesis to generate three different Oxtr-null mutant prairie vole lines

[literaturepublishersjournal]

Clinical Images and Case Reports Journal 

About Journal

Clinical Images and Case Reports Journal (CICRJ) is a peer-reviewed indexed medical journal established Internationally which provides a platform to publish Clinical Images, Medical Case Reports, Clinical Case Reports, Case Series (series of 2 to 6 cases), Research and Clinical Videos in Medicine. Clinical image journal is a indexed journal accepting clinical images submission, journal of clinical images, journals publishing clinical images in medicine, clinical imaging submission journal and medical illustrations etc. Journal of clinical case reports publishes case reports in clinical medicine, clinical reports, journals accepting clinical case reports submission and journal of clinical cases. Journal of medical case reports publishing medical case reports, journals accepting medical case reports submission etc.

[evajones24]

“4th International Conference on #Diabetes, #Endocrinology and #Obesity”. The conference will bring together experts and professionals from the field of Diabetes, Endocrinology and Obesity to exchange knowledge and insights into the latest research, treatments, and practices. The conference is scheduled to take place on ​March 11-12, 2024 at Rome, Italy.  For More Details: https://www.diabetesmeet.com/ Abstract Submission: https://www.diabetesmeet.com/Submit_Abstract For Registration: https://www.diabetesmeet.com/Registration

Email: diabetesmeet@diabetesspeakerexperts.org

[genderkoolaid]

A common concern about gender-affirming hormone therapy for transmasculine people is the risk of red blood cell volume changes and erythrocytosis, a high concentration of red blood cells, with the use of prescribed testosterone. However, Mount Sinai researchers have found that testosterone treatment may be safer than previously reported, with results published today in The Journal of Clinical Endocrinology and Metabolism. Mount Sinai researchers from the Division of Endocrinology and Center for Transgender Medicine and Surgery examined the relationship between the use of testosterone as part of gender-affirming hormone therapy (GAHT) for transmasculine individuals and changes in hematocrit, a test that measures how much of a person's blood is made up of red blood cells. The study of a large North American cohort is the largest on this subject to date. [...] Researchers found that higher testosterone levels were associated with higher hematocrit levels, however, the magnitude of change in hematocrit was small and unlikely to be clinically meaningful. Only 8.4 percent of transmasculine individuals in the study had a hematocrit greater than 50 percent, and less than 1 percent had a hematocrit greater than 54 percent, the level at which treatment for erythrocytosis is recommended, often through the use of phlebotomy (bloodletting). These numbers are lower than those previously reported in smaller studies, and the finding of such a small degree of change in hematocrit and a lower risk of erythrocytosis should provide more assurance to those prescribing and using testosterone as GAHT.

Good news for everyone on T!

[ashleyrowanthewriter]

Porcelain Doll HRT Observation Report

Part I - WTO Foreword

The report is based on studies and observations performed by Dr. Pierre Oupée, Dr. Kotomi Abuki and Dr. Pirkko Osliini. The team studied 25 participants who underwent therapy including Dr. Osliini.

The therapy has been approved by the World Transhumanism Association, but every licensed physician administering the treatment has to report the course of therapy of at least 50% of patients for clarity of data. The therapy is to be submitted for reapproval once reports of at least 1000 patients are collected.

Part II - Recommended Psychological Evaluation

Before undergoing the therapy it is recommended to evaluate the patients psychologically. The evaluation should take three sessions, which should be performed in intervals of 14 days. The process of evaluation prioritises informed consent and letting the patient consider their decision.

The first session is focused on discussing the desired effects with the patient. During the second session the patient is to be explained about the effects of the therapy. During the third session the patient signs the informed consent file after which they can undergo an endocrinological evaluation and get prescribed the medications.

Part III - Required Medications

All medications are available in oral and epidermal form. It is important to note that the exact dosage differs from patient to patient.

Antihomogen (0,5-2 mg/week) - Humanity removal agent. Due to the anthropomorphic nature of the therapy it is important to keep the dosage low unless cross administering multiple therapies.

Antisomatotropin (10-17 mg/week) - Somatotropin halting agent.

Contostropin (13-22 mg/week) - Shrinking hormone. Due to the rate of influence the final dose should be taken when the patient reaches the height of 5-7 cm higher than desired. Further research is advised.

Tsichirone (17,5-32 mg/week) - Porcelanising agent.

Part IV - Course of Therapy

Phase 1 (onset on week 4-8) - Somatotropin in the patient’s body stops influencing it and constopropin causes it to start shrinking.

Phase 2 (onset on week 7-14) - Tsichirone starts turning the patient’s skin into soft porcelain. The effects of constotropine become amplified causing rapid decrease in height. The patient’s hair starts falling out. It is not understood what causes this effect, but it is observed that it doesn’t affect scalp hair. Further research is required.

Phase 3 (onset on week 20-30) - Tsichirone might cause the patient’s body to spontaneously freeze for a short time. The effect first affects small parts of the body such as single fingers to later spread to entire limbs and near the onset of phase 4 even the entire body. The patient’s scalp hair stops growing. It is not understood what causes this effect. Further research is required. The patient’s body hair falls out entirely midway through this phase. Tsichirone causes the patient’s skin to become more brittle. The patient’s hearing becomes more sensitive to high sounds. It is not understood what causes this effect. Further research is required.

Phase 4 (onset on week 40-56) - The patient’s body is completely turned into soft porcelain. While the patient retains muscle control for some time, tsichirone starts causing muscle atrophy and conversion of movable soft porcelain into immovable hard porcelain.

Phase 4A (10 weeks after the onset of phase 4) - The patient has to register in a surgery clinic licensed to perform dollification surgeries.

Phase 5 (onset on week 55-70) - Tsichirone causes complete conversion of soft porcelain into hard porcelain and complete muscle atrophy. The patient loses control over their body. Dollification surgeries become possible. The medication process is deemed completed.

Part V - Course of Surgeries

All the surgeries become possible after the patient reaches phase 5 of therapy. 

Articuplasty involves cutting the patient’s body and shaping new joints out of kintsugine. The joints become integrated with the patient's body after two to three weeks of auxiliary tsichirone therapy after which the patient is to undergo physical rehabilitation. Articuplasty is to be performed on shoulder joints, elbows, wrists, finger joints, hips, knees and ankles. If the patient expresses such desire, articuplasty can also be performed on toe joints, neck and some regions of the torso. The patients are able to use their joints despite muscle atrophy.

Voice box transplantation is not necessary for transition, but if the patient wishes not to undergo it, it is advised they learn sign language. The surgery involves cutting a hole in the body region chosen by the patient, inserting an artificial voice box and sealing the hole using kintsugine. The seal gets healed after one to two weeks of auxiliary tsichirone therapy. Although the voice box can be transplanted to any part of the body that is big enough to store it, it is highly recommended to transplant it into the neck or the torso.

Some patients express a desire for their post-transition forms to possess winding keys. In such cases it is possible for them to undergo winding key transplantation. The transplantation consists of drilling a hole in the patient’s body, constructing a key rail out of kintsugine, inserting the key and sealing the rail. The key becomes integrated into the patient’s body after two to three weeks of auxiliary tsichirone therapy, during which it is absolutely necessary not to touch the key. Touching the key during the auxiliary therapy may result in damage which may render the key unusable or require repeating the surgery. Winding the key seems to have no effect on the patient's physical state. It is however understood to cause feelings of relaxation. Further research is required.

Some patients express a desire for their post-transition forms to possess movable eyelids. In such cases it is possible for them to undergo palpebraplasty. The surgery involves cutting the eyelid rails into the patient’s eye sockets and shaping the eyelids out of kintsugine. The eyelids become integrated with the patient’s body after four to eight days of auxiliary tsichirone therapy. To ensure proper shape of the eyelids they are to be shaped in the closed position.

Part VI - Reversibility

The effects of the therapy are currently understood to be irreversible once the patient’s body enters phase 4 of the transition process. Further research is required.

Part VII - Contraindications

The therapy is not to be administered to patients with calcium deficiency until the deficiency is treated.

To prevent damage to the organism the therapy is not to be administered to patients with brittle bone disease.

Patients with any health conditions causing muscle atrophy are to be thoroughly observed by their physician.

The physician has the right to alter or completely halt therapy if it poses danger to the patient’s life.

Part VIII - WTO Approval

The World Transhumanism Organisation approved the therapy on August 2nd 20XX.

*************

Sorry, but I like the otherkin HRT genre too much. And while it will feel weird to self-insert myself into such a story as a receiver (because it seems my disability prevents me from gender HRT IRL), I thought I could write some lore bits to contribute to the community. It might not even be the only report I decide to write.

Of course, feel free to base your own story on that report. I'd be excited to read it!

[five-thousand-loaves-of-bread]

what is (chronic) autistic catatonia?

// why specify “autistic” catatonia? //

catatonia most common associate with schizophrenia, but increase realize also happen in things like bipolar & depression.

if look at some of typical catatonia diagnostic criteria in DSM 5 (but in easier words): catalepsy & waxy flexibility, grimacing (hold same stiff facial movement), mutism, echolalia, echopraxia (copy movement), exaggerated mannerisms, stereotypies/repetitive movements, etc… wait! some of these things happen in autism!!! (like 7 out of total 12 can be seen in autism)

this is why important to know how recognize catatonia in autism. because overlap.

catatonia in schizophrenia most common start fast and get worse fast. but chronic autistic catatonia typically slow onset and slow but visible deterioration. (always have exceptions though)

not know a lot about schizophrenia catatonia, so this post largely focus on autism. everything below, when say “catatonia” or “autistic catatonia,” mean chronic autistic catatonia with deterioration.

// before move on— //

sometimes professionals do connect autistic shutdown with/as catatonia or catatonia episode or catatonia-like episode to draw connection. this not talk about that. this about chronic ones with deterioration. personally for community identity purpose i don’t enjoy (already have term for shutdown). but personal opinion aside, again this about the temporary vs long term all the time. if experience temporary shutdown, remember to leave space for and not same as those of us deal with chronic autistic catatonia.

important to distinguish from autism because autism and catatonia share many symptoms. (for example, physical stimming or “stereotypies” is autism diagnostic criteria AND catatonia criteria). autistic catatonia should only be suspected IF have new symptoms OR change in type & pattern of old symptoms. cannot. stress. this. enough. again. it not about IF you have these symptoms it’s about WHEN and HOW and CHANGE. it's about NEW.

and. please do not diagnose self based on one tumblr post. yes even if i do extensive research and cite sources and have lived experience. many many many disorders look similar. am all here for educated self diagnosis because medical system inequitable BUT am also sick of every time write this a bunch people comment “oh never heard this this is so me.” one tumblr post not educated self dx. it not a cool new thing to add to carrd to hoard as much medical label as can, it miserable it makes my life hell it not a joke it not cool. not every autistic have chronic catatonia, not every shutdown means chronic catatonia, even if you autistic and see these signs, may be separate unrelated disorder altogether, like Infectious, metabolic, endocrinological, neurological, autoimmune diseases, all can see catatonia (Dhossche et al, 2006). some of you all will read this and truly think this is answer been looking for so long—great! still, please do more research.

// chronic autistic catatonia with deterioration and breakdown //

the key defining symptoms of chronic autistic catatonia is gradual lose functioning and difficulty with voluntary movements (shah, 2019, p21). “gradual lose functioning” will come with regression in independence & ADLs & quality of life. it usually gradual, chronic, and complex. but can vary in severity. some need prompts on some day & some situations, while others need prompt and even physical assistance for almost everything.

how common? have seen statistic estimate from 10% - 20% of autistic people adolescents & above experience chronic autistic catatonia.

typical onset for autistic catatonia is adolescence. some study samples is 15-19, some as early as 13. some professionals think this autistic catatonia may be a reason for many autism late regression (Ghaziuddin, 2021).

can happen regardless of gender, IQ (yes shitty), “autism severity/functioning labels” (is what most studies use, so i keep, but yes have issues, probably also mean happens regardless of autism level 1/2/3 and support needs before catatonia, but need more research to confirm since these thing don’t equal eachother).

// primary symptoms //

from book "Catatonia, Shutdown and Breakdown in Autism: A Psycho-Ecological Approach" by dr amitta shah, recommend read at least first two chapter and appendix.

1. Increased slowness

often first sign but not always

periods of inactivity or immobility between actions which appears as slowness, e.g walking, responses (verbal & body), self care, mealtime, etc

2. Movement difficulties (freezing and getting stuck)

difficult initiate/start movement

freeze or become "stuck" in middle of activity for few seconds to minutes

hesitate & "to and fro" movements

difficulty cross threshold/transitions like door way

difficulty stop action/movement once started

affect speech content, fluency, & volume

eat & drink difficult (like movement for fork & knife, chewing and swallowing, etc)

spend long time in one place

(new) ritualistic behaviors

3. Movement abnormalities

repetitive movements like in tourette's & parkinsons

e.g. sudden jerky movement, tremors, involuntary movements, blinking, grimacing, unusual & uncomfortable postures, locked in postures, increase in repetitive movements, etc.

4. Prompt dependence

may not be able to do some or any movement/activity, unable to move from one place to another, unable to change posture, etc without external/outside prompt

5. Passivity and apparent lack of motivation

look unmotivated & unwilling to do stuff, include activities used to like, probably because can't do voluntary action or have trouble with request and make decison.

6. Posturing

classic catatonia symptom of being stuck in one posture, sometimes for hours

7. Periods of shutdown

8. Catatonic excitement

episodic & short lasting

e.g. uncontrollable & frenzied movement and vocalizations, sensory/perceptual distortions, aggressive & destructive outbursts that not like self

9. Fluctuations of difficulty

e.g. some days better can do more need less prompt! other days worse. sometimes emergency can act as almost like a prompt! but fluctuate doesn't mean difficulty voluntary

// secondary difficulties //

Social withdrawal and communication problems

Decline in self-help skills

Incontinence

‘Challenging’ behavior

Mobility and muscle wastage

Physical problems

Breakdown

// autism breakdown //

can be in addition to autistic catatonia. can look like autism is getting worse, even though autism by itself not progressive disorder!

i also call this autism late regression. separate between autistic catatonia & this not very clear, not enough research.

1. exacerbation of autism

1a. increased social withdrawl, isolation, avoidance of social situations

1b. increased communication difficulties

1c. increased repetitive and ritualistic behavior

2. decrease in tolerance & resilience

easily disturbed, irratable, angry

3. increase in "challenging" behaviors

e.g. self injurious behaviors

4. decrease in concentration & focus

5. decrease in engagement & enjoyment

// treatment //

for catatonia (autistic or not), typical treatment is lorazepam and/or ECT.

specific to catatonia in autism, Dhossche et al. (2006) separate it to mild/moderate/severe and give recommend treatment according to that (do not come here and argue about severity labels, because fuck! mild depression and severe depression of course have different suggested treatments and severity important to know. Remember we talk about autistic catatonia).

note: this is one paper! not the only way! yes have problems like most psych/autism papers, just here to give example (of range of symptoms and treatment route!). NOT MEDICAL ADVICE. (not even endorsement)

mild: slight impairment in social & job things without limit efficiency as a whole (essentially still able to function for most part but difficult).

moderate: more obvious struggles in all areas, but ambulatory and don't need acute medical services for feeding or vitals

severe: typically medical emergency, acute stupor, immobility for most of day, bedridden, need other people help feed. also malignant catatonia which can be life-threatening (fever, altered consciousness, stupor, and autonomic instability as evidenced by lability of blood pressure, tachycardia, vasoconstriction, and diaphoresis, whatever any of that means)

the "shaw-wing approach": very brief summary, keep person active and do thing they enjoy, use verbal & gentle physical prompts, have structure & routine.

lorazopem challenge: take 2-4 mg of lorazopem to see changes in next 2-5 minutes. if no change, another 1 mg and reassess

lorazopem trial up to 24 mg. (note difference between challenge & trial)

bilateral ECT, last resort.

mild: "shaw-wing approach" -> 2 week lorazopem trial if no imporvement in 1 month -> if effective, do both, if not, just shaw-wing approach

moderate: depends on prefernece, either shaw-wing alone or shaw-wing and 2 week lorazopem trial -> if not effective, do 2 week lorazopem trial if havent already -> if not, bilateral ECT

severe: lorazepam challenge test -> if not effective, bilateral ECT; -> if lorazopem challange positive, 1 week lorazopem trial -> continue if successful, bilateral ECT if not.

can sound extreme, but rememeber for many severe catatonia (autistic or not), it is medical emergency. can be life-threatening. there's no/not a lot of time.

it possible to make partial recovery, as in get better but not to before catatonia. but overall, many permanently lose previous level of functioning.

references

Dhossche, D. M., Shah, A., & Wing, L. (2006). Blueprints for the assessment, treatment, and future study of Catatonia in autism spectrum disorders. International Review of Neurobiology, 267–284. https://doi.org/10.1016/s0074-7742(05)72016-x

Ghaziuddin, M. (2021). Catatonia: A common cause of late regression in autism. Frontiers in Psychiatry, 12. https://doi.org/10.3389/fpsyt.2021.674009

Ghaziuddin, M., Quinlan, P., & Ghaziuddin, N. (2005). Catatonia in autism: A distinct subtype? Journal of Intellectual Disability Research, 49(1), 102–105. https://doi.org/10.1111/j.1365-2788.2005.00666.x

Shah, A. (2019). Catatonia, shutdown and breakdown in autism: A psycho-ecological approach. Jessica Kingsley Publishers.

[ashes2caches]

all i’m saying is that if we rerouted all the funds going to cancer research into endocrinology instead we could probably synthesize an instant forcefem pill before 2030.

[medphieldphannies]

hey yall!! i'm mando @amusedphan (he/him); i currently volunteer in a repro lab (where i met @tarotphil!) where i will do an indep. research project next year, aka my last year of an extended immunology & infection BS(c). i'm probably going to stay in graduate school (medsci) for at least another decade, but eventually i want to go into forensic pathology. i'm most familiar with the med school process in canada

sex differentiation is probably a special interest now, with endocrinology as a focal point (sex and neuro hormones especially). that being said, things like psych/neuro and inflammation also interest me immensely, and the potential clinical relevance/application of research too. if you ever want pointers with writing (academic or otherwise tbh), just give me a shout!

i got into dnp probably via tumblr ~a decade ago, stopped watching around high school (minus BIG), and only started becoming interested again when @cactuslester especially became more active (who i must've followed back in 2014-15; thanks jess <3). i'm just glad i now have somewhere to scream when dan/phil/pj don't know which side of the chest the heart is located, dan puts essential oils into a cocktail they both drink, and i come up with a whole scifi-medical explanation on how dil's mpreg alien pregnancy worked :)

[mindblowingscience]

Researchers have found a correlation between flavonoids, a compound found in fruits and vegetables, and a reduction in the symptoms of endometriosis. In the study, published in the journal Endocrinology, the researchers outline how flavonoids may be able to help suppress the symptoms of inflammatory diseases like endometriosis. In endometriosis, cells similar to those in the lining of the uterus begin growing in other places in the body, causing inflammation. The painful condition affects millions of women, and there is no cure. Flavonoids have been associated with anticancer, antioxidant, anti-inflammatory, and antiviral medical benefits, but the details of how they work have remained a mystery. “Scientists have known for a while that people who eat more fruits and vegetables tend to live longer and have lower risk for many types of diseases, including Parkinson’s and Alzheimer’s diseases,” says Stephen Safe, a professor in the veterinary physiology and pharmacology department at the School of Veterinary Medicine and Biomedical Sciences at Texas A&M University.

Continue Reading.

[crossdreamers]

An improved awareness of the complexity of biological sex may help shape the research and teaching of future biologists.

The University of Oklahoma has made a course on the Diversity of Biological Sex Characteristics.

Ari Berkowitz writes:

«…we explore nonhuman sexual diversity, including fungi that have thousands of sexes and aphids that reproduce asexually most of the year but sexually once each fall. Among many others, we also learn about fish that are male or female at different times of their lives; intersex crayfish; and female spotted hyenas that have a penis….»

The course also shows that most people have some brain structures that are more typically male, others that are more typically female and still others that are intermediate.

In other words: There is no clear cut «male brain». Nature does not care about the strict binaries of human traditionalists.

[literaturepublishersjournal]

https://www.literaturepublishers.org/

Clinical Images and Case Reports Journal

Submit Manuscript or email at

editor.cicrj@literaturepublishers.org

imagecase@literaturepublishers.com

[shabbytigers]

when they say the clock in the brain, they could mean the pineal gland (which you can in fact surgically remove to make an animal insensitive to zeitgebers), the SCN (the main site of the circadian pacemaker) or, more likely given the mention of genetics, genes like BMAL1 and CLOCK. Sadly a Google Scholar search for BMAL1 agonist and CLOCK agonist comes up empty -- maybe it's cause they're (sometimes) in the nucleus?

interesting! i haven’t looked into this properly tbh, it was a purely visceral gut reaction, but now i Want to Know 😤

am also being advised via messages: acth issues typically, created by elevated crh, pursuant to some imbalance such as low cortisol

endocrinology gnarly as hell tbh only immunology is worse, i would so much rather be looking at the genetic level. but clearly the functional level is the more meaningful here, esp if as you say the research on targetability isn’t there. pineal gland prolly checks out if that’s where animal research along these lines already exists. this is all depressingly unfriendly to applied broscience but oh well

nota bene, i haven’t made it to sleep before 5 am for four days straight and my ability to sleep in to compensate is much attenuated. this blathering may have bugs