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qrtumb · 1 year

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Global Anticoagulant Market End User, Trends, and Outlook

The Global Anticoagulants market was valued at US$ 34.0 billion in 2021 and is anticipated to reach at USD 60.8 billion by 2027 at a CAGR 10.2% from 2022-2027.

Anticoagulant drugs (also called as blood thinner) are chemical substances prevent or reduce blood and increase the blood clotting time. These drugs are chiefly used for high risk of blood clots in various medical conditions such as atrial fibrillation, deep vein thrombosis, myocardial infraction, pulmonary embolism, stroke and others.

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Market Drivers

The Global anticoagulant industry is expected to show remarkable growth in the upcoming period due to increasing incidence of venous thromboembolism (VTE) and cardiovascular disorders, increasing adoption of novel oral anticoagulants, and rise in knowledge of NOACs in developing countries. Additionally, rise in number of obese and elderly people, higher unmet needs flow in demand of novel therapeutics promote the market growth. Oral anticoagulants market has observed the steady growth and there is fast expansion in product productions. Over the past decade, more patient-friendly, better compliant dosage form improved demand for oral coagulants market.

Market Restraints

Higher price of NOACs and lack of antidots for NOACs hamper the anticoagulant market. The novel oral anticoagulants are new class of anticoagulant drugs. NOCs have major pharmacologic benefit over warfarin, such as fast onset and offset of action, minimum drug interactions, and predictable pharmacokinetics. Although, these novel drugs have higher price and lead to rise in healthcare costs that may limit their adoption and in turn impede the anticoagulant market growth.

Market segmentation

The Global Anticoagulants market is segmented into Drug Class, route of administration, Application.

By Drug Class such as NOACs (Eliquis, Bevyxxa, Xarelto, Savaysa & lixiana, Pradaxa), Heparin & LMWH, Vitamin K Antagonist, Others. By Route of Administration such as Oral anticoagulant, Injectable anticoagulant. By Application such as Atrial fibrillation & heart attack, Stroke, Deep vein thrombosis (DVT), Pulmonary embolism (PE), Others.

Regional Analysis

The Global Anticoagulants market is segmented into five regions North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America brings about a revenue of USD 10.10 billion in 2018 and is expected to turn up superior in the global market during the forecast period. Asia Pacific is anticipated to witness the highest growth in the market value. Europe is anticipated to witness noteworthy growth in the market due to cardiovascular disease causes more than half of all deaths across the region, that is resulting in the higher adoption of blood thinning medications.

Key Players

Various Key Players are listed in this report such as Boehringer Ingelheim, BMS, Johnson & Johnson, Sanofi, Pfizer Inc., AstraZeneca, Bayer, Cellceutix, Cosmo Pharmaceuticals, CSL Behring.

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Market Taxonomy

By Drug Class

NOACs

Eliquis

Bevyxxa

Xarelto

Savaysa & lixiana

Pradaxa

Heparin & LMWH

Vitamin K Antagonist

Others

By Route of Administration

Oral anticoagulant

Injectable anticoagulant.

By Application

Atrial fibrillation & heart attack

Stroke

Deep vein thrombosis (DVT)

Pulmonary embolism (PE)

Others.

By Region

North America

Latin America

Europe

Asia Pacific

Middle East & Africa.

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wiccan-succulento · 3 years

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Aconitum Napellus

*This is a POISON.

(I know a lot of this is medical terms and may be hard to understand- I basically look up every term I come across. I’ve included definitions for most, but not all. I have tried finding my list of sources, but I have lost them. I have NOT personally had experience with this; therefore, some information may be slightly off, or not accurate according to new studies. Feel free to add new information, definitions, or facts. I am NOT a health professional.)

Common Names: Aconite, Monk’s Hood, Wolf’s Bane, Blue Rocket, Queen of Poisons, Soldier’s Helmet, Devil’s Helmet, Mouse Bane, Leopard’s Bane, Women's’ Bane, Brute Killer, Dog Killer

Native to: Central and Western Europe, Asia

Toxicity: Severe. All parts of the plants are toxic, especially the roots and root tubers

Poison will enter the body through contact with skin, contact with broken skin or wounds, ingestion, consuming any part of the plant.

The taste of the poison is a very bitter one, followed by a burning of the mouth and possibly esophagus, then numbing of the mouth.

Toxins in the plant include:

Aconitine- cardiotoxin (heart toxin) and neurotoxin (nerve toxin)

Mesaconitine

Hypaconitine

Side Effects can take a few minutes to a few hours to show.

Side Effects Include:

Abdominal Pain

Nausea

Vomiting

General Numbness

Partial Paralysis

Respiratory Paralysis

Paresthesia- abnormal sensation of the skin (tingling, numbness, chilling, burning, prickling) with no apparent physical cause

Diarrhea

Bradycardia- abnormally slow heart rythym

Hypotension

Chest pain

Palpitations

Sinus tachycardia- elevated sinus rhythm characterized by an increase in the rate of electrical impulses arising from the sinoatrial node (group of cells in the wall of the heart’s right atrium). In adults, sinus tachycardia is defined as a heart rate greater than 100 beats/min (bpm)

Ventricular ectopics- extra heart beats originating in the bottom heart chambers

Ventricular tachycardia- fast abnormal heart rate

Ventricular fibrillation- rapid and erratic electrical impulses of the heart

Defective color vision

The main causes of death are refractory ventricular arrhythmias & asystole. The severity of the toxins are related to the onset of rapid heart rhythm changes

Preexisting health conditions, old age, pregnancy, and breast feeding may amplify the side effects.

Overall in-hospital mortality is 5.5%

Antidotes & Remedies-

It has been reported that the effects of aconite can be buffered/eliminated by various alchemical methods.

Management is supportive, including immediate attention to vital functions and close monitoring of blood pressure & cardiac rhythm.

Inotropic therapy** is required if hypotension persists. Atropine*^ should be used to treat bradycardia.

Aconite-induced ventricular arrhythmias are often refractory to direct current cardioversion & antiarrhythmic drugs.

Available clinical evidence suggests that amiodarone & flecainide are reasonable first-line treatment.

In refractory cases of ventricular arrhythmias & cardiogenic shock, it’s most important to maintain systemic blood flow, blood pressure, & tissue oxygenation by early use of cardiopulmonary bypass.

The role of charcoal hemoperfusion to remove circulating aconitine alkaloids is not established.)

The early use of cardiopulmonary bypass is recommended if ventricular arrhythmias and cardiogenic shock are refractory to first-line treatment

**An inotrope is an agent that alters the force or energy of muscular contractions

*^ Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery

Reducing toxicity-

Boiling, steaming, or soaking the plant may reduce toxicity due to the toxins being heat sensitive alkaloids. Since the toxic effect of raw aconite can be buffered/eliminated altogether by various alchemical methods, early Chinese medical texts focus much attention on processes involving the production of processed aconite. This includes procedures with special growing & harvesting techniques, special processing techniques, & herb combining techniques that blend the processed root with other foods and medicinal substances to safeguard against negative side effects.

Ancient Chinese herbalists espoused a distinct concept of space referred to as “daodi yaocai” (herbs grown in a proper location). This concept is especially used when dealing with a variation of the Aconitum Napellus plant.

Li Shizhen and other ancient authorities of Chinese materia medica invariably state that “the best [aconite] is produced in Mianzhu in the region of Shu (northern part of today’s Sichuan province). Although aconite plants can also be found in other areas, they are unsuitable for treating disease.” A Song dynasty account gives a description of this particular region that is still known for producing China’s only “genuine” aconite

The Chinese materia medica contains about 70 recorded types of post-harvest processing techniques aimed at reducing the toxic potential of aconite. The toxic effect of aconite stems from its alkaloids, especially aconitine. Since this ingredient is sensitive to heating, the processes of roasting, boiling or in most recent times, pressure-steaming, can reduce the effects of most alkaloids. Ancient Chinese texts specify that before heating, the aconite tuber should be peeled with bamboo knives. This labor-intensive technique has been abandoned in the modern production of medicinal aconite.

There is emphasis on the removal of the salt used for preservation of the aconite tubers after the harvest before they are brought to market. After the harvest, the unprocessed aconite root will decay rapidly (within a week) unless it is immediately immersed in brine. Brine immersion will embalm the root during the time when the entire year’s harvest is waiting for the typical step-by-step detoxification process consisting of skin removal and the application of heat. Traditional paozhi techniques specify that all brine is removed from the raw aconite slices before steaming or baking them, by soaking and rinsing them repeatedly in basins of fresh water. Seasoned Fire School practitioners, i.e. the contemporary scholar-physicians Drs. Lu Chonghan and Liu Lihong, have observed that industrial aconite production during the last two decades has flooded the market with high salt content aconite slices. To most kidney deficient patients, this significant salt residue in most pharmacy grade aconite (70% in most contemporary aconite products) is harmful and may be partially responsible for some of the side effects associated with aconitine alkaloids in the pharmacological literature. In addition, it has become common practice in recent years to remove the root peel by immersion in hydrochloric acid, defying the stringent alchemical experience of aconite detoxification garnered during the last two millennia.

Medicinal Uses -

Medicinal applications of aconite were not fully explored until the 18th century when Viennese physician Anton Stoerck published his clinical observations about benefits of the “internal use of aconite in humans” in 1762. Alleged therapeutic uses include treatment of joint & muscle pain. As a tincture applied to skin, it’s claimed to slow heart rate in cardiac patients. Other claimed uses: reduction of fevers & cold symptoms. Some take it by mouth for facial paralysis, joint pain, gout, finger numbness, cold hands & feet, inflammation, painful breathing & fluid in space surrounding the lungs (pleurisy), certain heart problems (pericarditis sicca), fever, skin diseases, & hair loss. Aconite is also used as a disinfectant to treat wounds & promote sweating. Some apply aconite to skin in liniment as a “counter irritant” for treating facial pain, joint pain, & leg pain (sciatica). Aconite root contains chemicals that may improve circulation, but also contains chemicals that can harm the heart, muscles, & nerves

History-

Aconitum Napellus was used in ancient times as poison on spears and arrows for hunting and battles. The tips and (possibly) shafts pf arrows were covered with the poison so anyone helping a wounded soldier may get poisoned as well by skin contact.

As wolfsbane, it was believed to repel werewolves and wolves. The poison was placed in raw meat which would kill wolves attacking livestock.

Ancient Romans used it as a method of execution.

In Hong Kong, aconite is the most common cause of severe poisoning from herbs. In Asia, toxicity is related to the use of aconite in traditional medicines. In western countries, aconite poisoning is associated with consuming the plant

Supposedly used in times of war by retreating armies to poison enemy water supplies. Generals would realize the poisoning and be forced not to pursue the enemy.

The poison was placed on the tips of harpoons to kill whales more easily.

The murder of Percy John by his brother-in-law, Dr. George Henry Lampson, was carried out using aconite

“If [aconite] sap is condensed by simmering, it is called Shewang (Shooting Net) and used to kill wild animals.” The 5th century Daoist hermit Tao Hongjing elaborates further: “When the sap of the raw [aconite] vine is extracted by mortaring it to a pulp, and then concentrating it by simmering, the paste yielded from this process is called Shewang. Arrows dipped into it can be used by hunters to shoot wild animals; when hit by such an arrow, an animal will fall to the ground after 10 steps. If a human is struck by such an arrow, s/he will die as well, unless the poison is swiftly neutralized by an antidote.

Known Cases

Very low margin of safety between therapeutic and toxic doses of aconitine.

A 66-year-old female with no known heart disease obtained Aconite from an herbalist. She was instructed to make tea with it to treat her osteoarthritis*. About 90 minutes after consuming the tea she developed numbness of the face, arms, & legs. Rapidly followed by nausea, weakness, & chest pressure. In an Emergency Room, she was found to have an abnormal heart rhythm. After 4 hours of treatment with drugs & electrical shocks to her heart, a normal heart rhythm was restored.

* most common form of arthritis. It occurs when the protective cartilage cushioning the ends of bones wears down over time

There are cases of poisoning in which people intentionally swallow Aconitum napellus they grow because of claimed therapeutic effects. A 21-year-old male acquired Aconitum napellus plants after reading a book on herbal medicine. He ground up the dried roots & filled capsules with the material. He took 1 capsule daily for several months to treat anxiety. (No symptoms were reported during that time) In order to increase the effects one evening, he swallowed 3 capsules and went to sleep. Five hours later he awoke with generalized numbness, nausea, diarrhea, dizziness, chest pain, shortness of breath, & defective color vision (seeing purple). It was believed that early symptoms went unnoticed because he was asleep. In an ER, his heart rate was 43 bpm, and he had an abnormal heart rhythm. Plasma concentrations of aconitine supported poisoning by A. napellus. He spent 48 days in the hospital.

SOURCES: N/A, my list was lost when moving my information to a new document. I know for a fact I have spanned at least 6 websites, and 2 YouTube videos (only one of which was helpful) as well as the materia medica of John Henry Clark

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ayamari-no-goshi · 3 years

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Strychnos nux-vomica

Because I want to talk about poisonous plants and share knowledge.

Strychnos Nux-vomica, also known as the Strychnine Tree, and Nux Vomica.

This is a deciduous tree native to ndia, Sri Lanka, West Indies, and Australia. It is considered a medium sized tree with a short truck and ashen colored bark. Leaves are oval shaped - about 4 inches long and 3 inches wide.

Flowers are a white or a pale green color which are said to have an unpleasant smell. The fruit tend to be orange or a reddish orange and are about an 1 1/2 inches in diameter. The seeds are button shaped and are sometimes called “Quaker buttons’ or ‘poison nuts’

(Images from Zhuju Wang from the publication: Botany, Phytochemistry, Pharmacology and Toxicity of Strychnos nux-vomica L.: A Review)

Mixtures made from the plant have added to arrows for hunting use, and it was commonly made into a rat poison. It’s also been used off and on as treatment for various ailments, and it has investigated for potential cancer treatments. Some believe it might have performance enhancing effects, and athletes have used it for that purpose. In the last few years, I saw a certain health foods store market it as a hangover cure. However, there is no currently supported use for it in medicine.

The reason this tree is notorious is because it’s the main source of the poison strychnine, and every part of the tree either contains strychnine or another toxin.

If you’re familiar with the word strychnine, it’s probably from reading a murder mystery as it has been a choice for poisoners in the past. It’s considered to be one of the most unpleasant natural poisons.

Purified, it is a white, odorless, and bitter crystalline powder. The lethal dose for adult humans ranges from 30mg-120mg, possibly less. For children, it may be as little as 5mg.

It works by preventing glycine binding in the spinal cord. This allows chloride channels to open which causes all muscles controlled by the spinal cord to be stimulated. As a result, severe muscle spasms, arching of the neck and back (similar to severe tetanus cases), seizures, rigid arms, and a clenched jaw have been seen in poisoning cases. These symptoms often occur within 30 minutes. It can be in as little as 5 minutes if inhaled or given through IV.

Other symptoms include: agitation, fear, difficulty breathing, darkened urine, increased heart rate and pressure, kidney failure (as a direct result of muscle damage), respiratory failure, hyperthermia (a dangerous raise of body temperature), shock, and death.

If ingested, activated charcoal can be given in an attempt to prevent more of it from getting into the system. However, most of the treatment is supportive and treats the effects as there is no known antidote.

Patients may be given a benzodiazepine (diazepam being the most common) to treat the spasms and seizures. Phenobarbital (a barbiturate) may be given if the benzodiazepine isn’t effective. If that is still not enough, a neuromuscular blocker (examples: succinylcholine, rouronium), intubation, and mechanical ventilation are needed.

This toxin isn’t known for having long term effects. So unless the kidneys or brain was damaged while the poison ran its course, a person will make a full recovery.

It’s half-life in the body is 10-16 hours, so it could take up to 3 days for body to get rid of it.

Image from Köhler's Medicinal Plants.

My sources for information include: https://www.sciencedirect.com/ www.wildernessarena.com encyclopediaBritannica the CDC Micromedex/Drugdex https://pubchem.ncbi.nlm.nih.gov/ https://www.ncbi.nlm.nih.gov/books/NBK459306/

#poisonous plants #plants #botany #toxicology #poisons #the more you know #fun facts #toxins #i included my sources #strychnine #strychnine tree #nux vomica

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healthcare-market · 2 years

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Antidotes Market : Global Industry Revenue and Share by Manufacturers

Antidotes are medicines, chelating drugs, or pharmaceutical ingredients that neutralize the effect of poison or another drug. Paracetamol poisoning is the major concern all over the world as it is the most common drug taken in intentional overdose. Opioid poisoning, cyanide poisoning, benzodiazepine poisoning and other toxins can be neutralized using antidotes. Different types of antidotes are available to neutralize the effect of one particular drug and to reduce the toxicity of many drugs. There are antidotes that are 100% effective, while some can cause fatalities. Examples of antidotes are pralidoxime for poisoning by anti-cholinesterase nerve agents, naloxone for opioid overdose, methylene blue for drug-induced methemoglobinemia, flumazenil for benzodiazepine overdose, dimercaprol for arsenic, gold, or inorganic mercury poisoning, digoxin immune fab for digoxin toxicity, atropine for organophosphates and carbamates, activated charcoal for most poisons, and acetylcysteine for acetaminophen poisoning.

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According to the World Health Organization (WHO), over 5 million people across the world suffer from snake bites each year, and nearly 100,000 of these develop severe sequela. Mortality rate in developing countries in Asia Pacific such as India was approximately 30,000, whereas in developed countries in North America such as the U.S. it was 50,000 cases of bites, of which 7,000 were by venomous snakes.

Increase in awareness and studies regarding the identification of toxins of venomous bites by companies and governments to increase the knowledge of antidotes and drugs is projected to drive the global antidotes market during the forecast period. Rise in prevalence of the medical conditions associated with antidotes such as trichotillomania, toxoplasmosis prophylaxis, smoking cessation, reversal of sedation, reversal of opioid sedation, pneumocystis pneumonia prophylaxis, and opioid overdose drives demand for antidotes. However, rise in prices of anti-venoms is anticipated to restrain the global antidotes market during the forecast period.

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The global antidotes market can be segmented based on antidote type, dosage form, mode of action, and region. In terms of antidote type, the market can be categorized into chemical antidotes, physical antidotes, and pharmacological antidotes. Based on dosage form, the global antidotes market can be bifurcated into oral and injectable. Oral dosage can be divided into capsules or tablets, and syrup. Based on mode of action, the market can be segmented into poison, drug, and toxin.

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Geographically, the global antidotes market can be segmented into Latin America, Asia Pacific, Europe, North America, and Middle East & Africa. North America held the largest market share in 2016, due to increase in research and development on antidotes in the region. Europe held the second largest market share in 2016, due to technological advancements in antidotes. The market in Asia Pacific is anticipated to grow at a rapid pace during the forecast period owing to increase in prevalence of medical conditions associated with antidotes such as nerve agent poisoning, methotrexate rescue, methanol poisoning, mercury poisoning, lead poisoning, and gold poisoning. The market in Latin America and Middle East & Africa is anticipated to be driven by rise in government initiatives regarding antidotes.

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topmarketreportnews · 3 years

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Antidote Market - Global Industry Outlook Research Report 2021-2026 Added By DecisionDatabases

The global Antidote Market report offers a comprehensive assessment of the market for the forecast years. The report contains several segments and an analysis of the market trends and growth factors that are playing a vital role in the market. These factors encompass the drivers, restraints, and opportunities. This globe industry offers an outlook on the strategic development of the market in terms of revenue profits over the forecast period 2021-2026.

The key market players for the global Antidote market are listed below:

Roche

Pfizer

Bayer

Johnson & Johnson

Novartis

Eli Lilly

Teva

Boehringer Ingelheim

Mylan

Fresenius Kabi

Baxter

Furen Pharmaceutical

Others

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The Global Antidote Market Report is equipped with market data from 2016 to 2026. The report gives a market overview covering key drivers and risk factors. The report is bifurcated by top global manufactures mentioning sales, revenue, and prices as applicable. It also evaluates the competitive scenario of the leading players. The report expands to cover regional market data along with type and application. The report forecasts sales and revenue from 2021 to 2026. The detailed sales channel is also covered in the study.

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By Types:

Chemical Antidotes

Physical Antidotes

Pharmacological Antidotes

By Applications:

Pesticide Poisoning

Heavy Metal Poisoning

Animal Bites Poisoning

Cyanide Poisoning

Others

By Regions:

North America (U.S., Canada, Mexico)

Europe (U.K., France, Germany, Spain, Italy, Central & Eastern Europe)

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Latin America (Brazil, Rest of L.A.)

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lookchem-cas · 3 years

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Succinic Acid CAS 110-15-6 manufacturer spot Succinic acid, Succinic acid quality assurance price

Succinic acid is an important "C4 platform compound", which is widely used in food, medicine and agriculture, as a raw material for the synthesis of 1,4-butanediol, tetrahydrofuran, N-methylpyrrolidone and biodegradable biopolymers such as polybutylene glycol succinate. The biosynthesis of 1 molar butanedioic acid will be a promising application. The biosynthesis of 1 mole of succinic acid will fix 1 mole of carbon dioxide, so the production of succinic acid by fermentation with carbon dioxide as raw material can not only reduce the cost of raw materials, but also reduce greenhouse gas emissions.

Succinic acid is also known as succinic acid. The molecular formula HOOCCH2CH2COOH. Succinic acid is found in amber, but also in a wide variety of plants and human and animal succinic acid tissues, such as immature grapes, beets and rhubarb, human blood and muscle, bovine brain, spleen and thyroid gland. Succinic acid is an intermediate in the metabolism of carbohydrates in the body. Succinic acid is widely distributed in the animal and plant kingdoms and was first discovered in 1550 by Agricola during the distillation of amber, hence the name succinic acid. Succinic acid (SA) is an intermediate in the synthesis of many organic substances and an important raw material for the manufacture of drugs, and is widely used in food, medicine and chemical industry. It is widely used in food, medicine, chemical industry and other fields, and with the development of the times, there are new breakthroughs in the application of succinic acid and its extension products.

Succinic acid is colorless crystal; relative density 1.572(25/4℃), melting point 188℃, decompose at 235℃; can be sublimated by distillation under reduced pressure; soluble in water, slightly soluble in ethanol, ether and acetone. As ionic chelating agent, succinic acid is used in the electroplating industry to prevent dissolution and pitting of metals; Succinic acid is a good surfactant, a component of descaling agents, soaps and emulsion breakers; Succinic acid can produce depilatory agents, toothpaste, cleaning agents, efficient wrinkle beauty esters. Succinic acid is also used in lubricants, additives, and elastomers.

Basic information

Chinese name: succinic acid

English name: succinic acid

Chinese name 2: succinic acid

English name 2: amber acid

CAS No.: 110-15-6

Molecular formula: C4H6O4

Molecular weight: 118.09

Physical and chemical properties

Main components: Content: ≥99.0%; sulfate ≤0.02%; heavy metal ≤0.002%; iron ≤ 0.002%; ash ≤ 0.1%.

Appearance and properties: Colorless or white, odorless and acidic prismatic or flaky crystals.

Melting point(℃): 185

Boiling point(℃): 235(decomposition)

Relative density (water=1): 1.57(15℃)

Solubility: soluble in water, ethanol, ether, acetone.

Succinic acid is widely used in pharmaceutical, dye, paper, textile, spice, coating, food, plastic and other industries; currently, the sales volume of industrial grade succinic acid is over 15,000t, largely produced by petrochemical method from butane through cis-butenedianhydride. Only succinic acid for the food market is produced by the fermentation method.

Butanedioic acid produced from butanedioic acid alkyd resin has good flexibilization, elasticity and water resistance, which can be used in the pharmaceutical industry to produce sulfonamides, vitamin A, vitamin B and hemostatic drugs; diphenyl ester of butanedioic acid is an intermediate of dyestuff, and reacts with amino anthraquinone to produce anthraquinone dyestuff; in addition, butanedioic acid also has a wide range of uses in paper manufacturing, textile industry, and can also be used as lubricants, photographic chemicals and It is also used as a raw material for lubricants, photographic chemicals and surfactants. Succinic acid is also used as a food acidifier for flavoring wine, feed, and candy. With sales of more than $400 million per year, it is conceivable that the market for succinic acid is quite large, so the main markets for succinic acid are in the following areas.

► Food industry application areas

Directly applied in food.

1、Acid (chemical) agent ;

2、Buffering agent, neutralizing agent;

3、Japanese sake, fermented soybean paste, soy sauce, cool drinks, sugar products and other flavoring agents.

Synthesize a variety of food additives from other raw materials.

1, emulsifier, dough improver, nutritional supplements;

2、Preparation of berry flavors and as a solvent for fruit-based spices;

3, flavor improver, acidifier, mainly used in the preparation of soy sauce and used in sausage, ham, surimi products, etc;

4、Dried shellac.

► Chemical industry applications

1、Biodegradable plastic (PBS);

2、Dimethyl succinate;

3、Electroplating PH value adjusting agent;

4、Alkyd resin;

5、Dyestuff;

6、Varnish viscosity stabilizer;

7、Lubricants and surfactants for photographic chemicals;

8、Candles.

�� Pharmaceutical industry applications

1、Diuretics, expectorants, vitamin A, vitamin B, sulfonamides, synthesis of hemostatic drugs;

2、Antidote, antitussive agent;

► Other application areas

1、An important organic reagent;

2、A widely used plant growth hormone.

Preparation method

Used in the preparation of pentacyclic compounds. The product is an organic chemical raw material with a wide range of applications. Dosing - electrochemical synthesis - decolorization - cooling crystallization - static system - centrifugal separation - drying - packaging

There are more industrial preparation methods, mainly as follows.

1. Oxidation method

Paraffin wax is deeply oxidized to produce a mixture of various carboxylic acids, and then separated by water distillation and crystallization to obtain succinic acid.

2. Hydrogenation method

Hydrogenation of maleic anhydride or transbutenedioic acid under the action of a catalyst produces succinic acid, which is then separated to obtain the finished product. The catalyst is nickel or precious metal, and the reaction temperature is about 130- 140℃.

3. Acrylic acid carbonyl synthesis method

Acrylic acid and carbon monoxide in the presence of a catalyst to produce butanedioic acid. Not yet industrialized.

4. Electrolytic oxidation method

Phthalic anhydride and sulfuric acid and water in the ratio of 1:0.5:4, electrolysis in a ceramic electrolyzer, can be obtained butanedioic acid. Electrolytic synthesis of raw materials for maleic acid or maleic anhydride, cathode and anode solution with dilute sulfuric acid, separated by a cationic membrane, cathode and anode are generally used lead plate, usually with a plate and frame electrolyzer synthesis.

5. Acetylene method

Acetylene reacts with carbon monoxide and water in the presence of [CO(CO)4] catalyst in acidic medium to obtain succinic acid, reaction temperature 80-250℃, pressure 2.94-49.03MPa.

6. Emerging fermentation method

Compared with traditional chemical methods, microbial fermentation method for succinic acid production has many advantages: competitive production cost; use of renewable agricultural resources, including carbon dioxide, as raw materials, avoiding the dependence on petrochemical raw materials; reduce the pollution of the environment by chemical synthesis process.

Precautions: Less toxic, irritating to eyes, skin and mucous membranes, not toxic to the whole body. This product is flammable and irritating. Less toxic, irritating to eyes, skin and mucous membranes, but not toxic to the whole body.

Environmental hazards: It is hazardous to the environment and can cause pollution to water bodies and the atmosphere.

Flammability hazard: The product is flammable and irritating.

Hazardous characteristics: Flammable when exposed to open flame and high heat. Powder and air can form an explosive mixture, when it reaches a certain concentration, it will explode in contact with a spark. Decomposition by high heat, emitting irritating fumes.

Pharmacological effects

1. Antibacterial effect of succinic acid at a concentration of 2mg/ml has an inhibitory effect on Staphylococcus aureus, Staphylococcus catarrhalis and Bacillus typhi, Pseudomonas aeruginosa, S. dysenteriae.

2. Central inhibitory effect rats, mice, guinea pigs, rabbits, cats and dogs intraperitoneal injection of succinic acid can protect animals against hyperbaric, electroconvulsive and auditory convulsions. The anticonvulsant effect is associated with increased GABA content in the brain. Hot plate method has analgesic effect and synergistic effect with pentobarbital, as well as sedative and hypothermic effect.

3. Anti-ulcer effect on gastric ulcer produced by pyloric ligation in rats, 50mg/kg injected intraperitoneally or orally, anti-ulcer effect due to inhibition of gastric juice secretion and dilatation of gastric muscle.

4. Effects on immune function: Succinic acid was dissolved in saline and pH adjusted to 6.4 by adding NaHCO3 at a concentration of 11.8%. 1mM (118mg)/kg, 2.5mM (295mg)/kg and 5mM (590mg)/kg were injected intraperitoneally into rats and rabbits daily for 7d, once daily. 0.025), but the increase in phagocytosis was not significant. In rabbits, the leukocyte count increased significantly at higher doses, and the phagocytosis rate also increased (P<0.01). In the specific skin reaction test, intraperitoneal injection of succinic acid 5mg/kg for 4 times in 48h or once daily for two weeks, succinic acid inhibited passive and active skin allergic reactions in rabbits and reduced the formation of serum 1gE antibody in animals.

5.Antitoxic effect Succinic acid has obvious protective effect on mice in poisonous cobra, and the rate of protection is similar to the original formula.

Source of ingredients

Succinic acid natural source is the resin of the pine plant buried in the ground for a long time to become amber, etc., in addition to a wide range of plants, animal tissue. Succinic acid is the resin of pine plant, buried in the ground for a long time to make amber, amber contains 7.8% of this product. Angelica sinensis (Oliv.) Diels root of Umbelliferae, Pothos chinensis (Raf.) Merr. of Tennantaceae, Lesspedeza caneata G. Don of Leguminosae, Lo-belia chinen-sis of Erythrinaceae Lour. whole herb, Orchidaceae Sarcardra glabra (Thumb.) Nakai whole herb, Sandalwood spice plant Thesium chinense Turcz. whole herb. Leguminosae Cloverleaf; Umbelliferae Angelicae Root; Tennantaceae Vine Orange; Erythrinaceae Hemipterocarpus; Orchidaceae; Sandalwood and Strawberry. Grapes, etc.

Product Center

Succinic acid (succinic acid) series

Succinic acid, disodium succinate(hexahydrate), disodium succinate(anhydrous), dipotassium succinate, calcium succinate, ammonium succinate, dimethyl succinate, diethyl succinate, diisopropyl succinate;

Phthalocyanine pigment series

Phthalocyanine blue BGS 15:3, Phthalocyanine blue BGS 15:4, Phthalocyanine blue B 15, Phthalocyanine green G 7, Copper phthalocyanine intermediate ≥95%

Product advantages

As the industry benchmark of supply chain service in the field of chemical products, we have senior industry experience and provide market advantageous price, and have won excellent reputation among many customers.

Industry field Strong strength

As the industry standard of supply chain service in the field of chemical products, we have perfected a set of accurate operation system and established long-term stable and reliable cooperation relationship with many famous chemical companies and large refineries.

Full range of products and sufficient inventory

The company currently operates more than a thousand kinds of chemical products, with factories, barrels, bagged warehouses, liquid storage tanks around the world; large storage capacity, stable supply

Professional team Service on paper

We have rich international trade experience and professional talents in the chemical field, professional customer service team "one-to-one" refinement service, to provide accurate quotation and consulting services, for your procurement comprehensive gate-keeping.

High quality products High quality price

Focus on the process of product quality control, adhere to only "genuine"; senior industry experience, to provide market advantageous prices, and won a good reputation among many customers.

About US

Anhui San-Xin Chemical Co., Ltd. is a manufacturer and operator of fine chemicals, including succinic acid, succinic anhydride and their derivatives. Our products include: succinic acid, succinic anhydride, sodium succinate, potassium succinate, butanediimide, dimethyl succinate, diethyl succinate, dibutyl succinate, etc. Our products are sold nationwide and overseas. Its products are sold nationwide and overseas and are widely used in pharmaceuticals, pesticides, dyestuffs, synthetic spices, synthetic resins, plastic additives, food additives, chemical analysis, electroplating and other fields.

The products are widely used and more than 90% of them are exported to more than 20 countries and regions such as USA, UK, Japan, France, Germany, Australia, Middle East, Hong Kong, Taiwan, Macau, etc. The sales network of the products spreads all over China and we have established long-term business relationships with some large and medium-sized enterprises. In 1997, it was recognized as a provincial high-tech product.

Our main products include food preservatives, food flavors and fragrances, food sweeteners, food emulsifiers, food bulking agents, food thickeners, antioxidants, nutritional fortificants, amino acids, vitamins, health care raw materials, pharmaceutical excipients and other products. The company has strict quality control procedures, scientific business management and efficient logistics operation system, which provide a solid guarantee for the customers to get stable, safe and high quality food additives. We strictly implement the requirements of ISO9001:2008 quality management system standard, and on the basis of this, our succinic acid series products have passed STAR-K certification, FDA certification, etc. Our main production and operation products are: succinic acid series products; we also deal with phthalocyanine organic pigment series, iron oxide series, refined anhydrous calcium chloride and other products.

The essence of Qino's corporate culture is "scientific and open, innovative and enterprising, behave honestly and do real work", which is interpreted with different cultural connotation at different times, and will inspire our Qino staff to strive for the pursuit. In today's increasingly competitive market, we will take strict product quality, reasonable transaction price, after-sales service and honest business reputation as the basis, in accordance with the company values of "the best and the most beautiful, mutual benefit and win-win", with a well-qualified, technical, young and competent staff team, in line with " Customer first, service" business philosophy, and the majority of business partners sincere cooperation, common development, and create a better future. For a long time, San-Xin people pursue the corporate philosophy of honesty and trustworthiness, customer first, and the enterprise spirit of dedication, collaboration, pragmatism and innovation, so that you can feel the sincere and satisfactory San-Xin service. Looking ahead, there is a long way to go, we will, as always, strengthen the friendship and cooperation with friends from all walks of life at home and abroad to promote the development of our common cause!

The future, butanedioic acid market development prospects

Succinic acid has a wide range of promising applications in food, pharmaceuticals, surfactants, green solvents, biodegradable plastics and other fields, and the chemical products market for its derivatives has a large potential. The most promising market at present is as the main raw material for the biodegradable plastic polybutylene glycol succinate. At present, the technology of synthesizing PBS biodegradable plastic from succinic acid has been successfully developed and put into mass production in BASF, Mitsubishi, Tsinghua University and Institute of Physical and Chemical Sciences, Chinese Academy of Sciences, etc. Compared with other biodegradable plastics, PBS not only has excellent mechanical properties, but also has reasonable price and high market demand.

In the future, the annual demand of PBS in China will reach more than 3 million tons, based on the production of 1 ton of PBS consuming 0.62 tons of succinic acid, the consumption of 1.8 million tons of succinic acid, and the current annual production capacity of succinic acid in China is far from being able to meet the needs of the market, the market growth of succinic acid is huge. At present, a number of domestic enterprises are actively preparing to start PBS projects, has successfully produced PBS enterprises Anqing and Xing 2009 production capacity of 10,000 tons, ready to follow up on the annual production capacity of 100,000 tons, Xinfu Pharmaceuticals annual production capacity of 3,000 tons, etc.. And with the successful development of PES plastic (organic polymer material obtained by condensation of succinic acid and ethylene glycol) and PHS plastic (organic polymer material obtained by condensation of succinic acid and adipic acid), two new degradable plastics, the demand for succinic acid will increase greatly. However, the traditional method of producing succinic acid which has been using non-renewable strategic resource petroleum products as raw materials has led to high prices and pollution, inhibiting the development potential of succinic acid as an excellent chemical platform product. The foreign production of succinic acid through biofermentation method uses cheap raw materials, and after reasonable process optimization, produces succinic acid products with more tremendous advantages and development potential, and with China's green industry attention, especially under the growing demand for global sustainable solutions, the competitiveness of biodegradable bio-based polybutylene succinate is enhanced, which will make the bio-based butanedioic acid market become bigger and this method will have a huge development potential.

#Succinic Acid

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hospitaldirectory · 3 years

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A Complete Guide on Autoclave machines

The term Autoclave is consequent from the mixture of a Greek word signifying self and Latin Clavis denoting key termed as a self-locking scheme. An autoclave machine is a high heated ampoule, spent for organic responses and manifold procedures by expending high temperatures and pressures. These machines are presented in dissimilar kinds and expended for diverse enterprises. Approximating, in chemical trades, they are expended to antidote coatings and to toughen rubber. Autoclaves manufactured by Autoclave manufacturers are also expended for hydrothermal mixture by developing minerals under high pressures or temperatures. The main characteristic of the machine is its functioning usage under high temperatures and pressures.

Vapor sanitizers and autoclave machines expended as sanitizers are totally similar. Autoclaves that are expended for vapor cleansing come in dissimilar kinds. They largely fall into three classes used as vapor sanitizers but intended for dissimilar working drives. They are located in infirmaries by physicians and dentists. They are in the arrangement of minor tabletop tool sanitizers which are usually used. These sanitizers are intended to deliver rapid and dependable fumigation of lesser consignments of operating tools commonly with one or two static sequences. The clusters that make usage of this kind of autoclave machine are big infirmaries and pharmacological sanitizers are intended to route them in enormous quantities on a manufacturing measure. The third group is research laboratory or research rating autoclaves. These autoclaves that are available with Autoclave suppliers are precisely intended to disinfect a massive assortment of disinfecting lots with their aptitude to set dissimilar temperatures and time well suited for separate lots.

Autoclave manufacturers yield numerous kinds of research laboratory autoclaves that are intended for diverse determinations. Therefore, it’s vital to comprehend your laboratory necessities in footings of incidence and weight used difference of disinfecting applications. Necessities can also array in footings of accessible laboratory space, a benchtop or bigger size free-standing is suitable or an obverse or top-loading autoclave is more appropriate. Autoclave manufacturers contrive their merchandise to proposition modified resolutions to meet the client’s wants as per the stipulations stipulated in footings of laboratory space and disinfecting requirements. The closing verdict on acquisition will typically be a compromise in rapports of connection space, appropriate for tenders and obtainable assets. The foremost kinds of autoclave machines available in the market with Autoclave suppliers in India are Benchtop, Top loading, Front loading, and Pass-through. These are obtainable in dissimilar entrance kinds, warming approaches, and cavity shapes, each proposing illustrious welfares.

Benchtop autoclaves are an apt select for minor laboratories consuming partial space, therefore the purification substances used are comparatively small and quantity being occasional. This kind of autoclave is exactly intended to be located on a workroom counter. This form of gear is almost an autonomous mechanism, with a detached project, that can be effortlessly linked to an apt power supply. It’s informal to connect and is comparatively one of the lowermost valued prototypes.

Usage of Top loading autoclaves is essentially a hands-on selection for research laboratories that are minor, but yet the mandate for high-quality presentation of vapor purification is anticipated. Top loading autoclave replicas tend to upsurge in tallness due to high bulk. The main benefit for smaller laboratories is the ‘imprint ‘of these machines which idyllically do not require much girth and distance outside the cavity space.

The Front Load Autoclaves come in round or quadrangular disinfecting cavities. This kind of autoclave has a benefit over top-loading autoclaves as they are suitable for consignment. Though, this autoclave necessitates a vast space. The disinfecting volume of the quadrangular cavity of a front-loading arrangement is greater than a top-loading cylindrical copy.

A laboratory is operated to carry out numerous practices and actions. To conduct such measures a disinfected setting is a necessity. Hence a perfect and safe withdrawal trail for the discarded to be cast off. The pass-through autoclaves are intended to deliver a pasteurized departure trail in and out of shutting research laboratories. Pass-through autoclave machines are also called dual ingresses. These autoclaves are also operated as a suppression application, wherein de-contamination of solid before its discharge from the control suit which would idyllically be a laboratory processing high-risk dangerous materials. This type of autoclaves found with Autoclave suppliers in India is deeply adapted in their project, in which two components are positioned one behind the other with a single cavity exposed on both ends to permit for doors at either end. When purchasing a pass-through autoclave it’s sensible to encompass the autoclave manufacturers at the early phase of design contingent on the locations you select. Each location may have dissimilar necessities like hinged doors to fluctuate left or right, water and gutter amenities, the site of the electrical power. Thus an autoclave manufacturer’s prerequisites to be retained in a circle from the first start themself. A pass-through autoclave is typically tailor-made to meet the purchaser’s exact solicitation.

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#autoclaves #Autoclave manufacturers #Autoclave suppliers #Autoclave suppliers in India #Autoclave manufacturers in India

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martblogs · 1 year

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Global Pharmacological Antidotes Market Industry Analysis And Forecast 2022-2028

This report provides a comprehensive analysis of current global Pharmacological Antidotes market based on segmented types and downstream applications. Major product development trends are discussed under major downstream segment scenario.

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According to this survey, the global Pharmacological Antidotes market is estimated to have reached $ xx million in 2020, and projected to grow at a CAGR of xx% to $ xx million by 2028.

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The Global Pharmacological Antidotes Market has been exhibited in detail in the following chapters

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lovejenniferthings · 3 years

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Global Antidote Market Manufacturers, Technology, Segmentation and Development Trends - Forecasts to 2025

Global Antidote Market report present indepth industry insights and complete forecast study. The new research report studies global as well as regional presence of Antidote Market. Development factors, growth opportunities and market drivers are the key highlights of the report.

The report provides information on major players of Antidote, their market position, revenue study, and growth tactics. Various applications, product types, and market value are focused in this wide report scope. Market drivers, growth opportunities throughout the forecast period is examined in this report. Growth rate and market value are also examined for global as well as region from 2015-2020.

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Roche Boehringer Ingelheim Pfizer Teva Bayer Fresenius Kabi Eli Lilly Novartis Mylan Johnson & Johnson Baxter Furen Pharmaceutical

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In the regions like North America, Europe, Asia-Pacific, Middle East & Africa, and Latin America, industrial development is presented in terms of revenue (USD Million).

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Chemical Antidotes Physical Antidotes Pharmacological Antidotes

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Pesticide Poisoning Heavy Metal Poisoning Animal Bites Poisoning Cyanide Poisoning

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Antidote industry news, plans & policies, market drivers, analysis of upstream raw material suppliers and downstream buyers of Antidote is carried out in this report.Forecast market statistics will pave the way to estimate the development and growth of the market. The facts and market numbers presented herewith are gathered from regulatory authorities. Dominating factors influencing the growth of leading market players & their presence in the market is analyzed in this report.Market share, import-export scenario, consumption ratio, production value, gross margin analysis, and SWOT analysis is calculated for the regions and countries.

Below is the 12 Chapters provided in the report to deliver a clear and detailed understanding of Antidote industry:

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This research report aids as a broad guideline which provides in-depth insights and detailed analysis of severaltrade verticals.

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clevertimetravelpaper · 2 years

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shinrakills · 5 years

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CBD cannabidiol - the key answers to the legal cannabis drug

When it came to hemp and cannabis, tetrahydrocannabinol (THC) was the dominant topic for a long time. More and more people are now hearing about cannabidiol (CBD) - but what is actually behind the trendy three letters? Why are there CBD products like capsules, oils, and drops? And is that legal in Austria and Germany? The most important answers and everything worth knowing about the coveted cannabis drug in the overview.

What is CBD?

Cannabidiol (CBD) is a natural cannabis drug - a so-called cannabinoid. It is derived from the cannabis sativa or cannabis indica female hemp and is the second highest concentration hemp drug after tetrahydrocannabinol (THC). Male hemp plants have no relevant levels of CBD. Like all other cannabinoids, cannabidiol is predominantly an acid in the hemp plant and is considered an inactive ingredient.

After Hanf can look back on a millennia-old history of usage, CBD was first discovered and extracted in 1940 in the United States. It was not until the second half of the twentieth century that the cannabinoid was studied separately and researched for its medical potential. To date, it is clearly in the shadow of tetrahydrocannabinol, which enjoys wide exploration.

Are cannabis and cannabidiol the same?

Because cannabidiol is derived from the hemp plant, it is also colloquially referred to as cannabis. Strictly speaking, however, it is a cannabis compound derived from the hemp plant. Simply calling it cannabis does not do it justice. Rather, it is necessary to distinguish between hemp, cannabis, THC, and CBD, as there may be large differences in some cases. For example, in the legal assessment.

Is CBD legal?

Due to its almost complete lack of psychoactive effect cannabidiol unlike other cannabinoids (such as THC) is legally available in many EU countries - as well as in Austria and Germany. Even the United Nations does not list it in the list for drug and crime control - in contrast to tetrahydrocannabinol.

Cannabidiol is authorized for cosmetic products - but is often marketed as a dietary supplement, often with a particular focus on use in electronic cigarettes as e-liquid. According to a Regulation of the European Parliament and of the Council, since 1997 it has also been considered "novel food" and may only be placed on the market if there is an EU-wide authorization.

Cannabidiol is therefore available legally and without a prescription in most EU countries, as well as Austria - but only from the age of 18 years. CBD products become illegal the moment you exceed 0.2% THC.

It can also be legally prescribed as a medicine by a doctor. Then it is possible to get it via prescription through the pharmacy. However, most health insurance companies do not reimburse these costs because it is a so-called prescription medicine.

What is the effect of cannabidiol?

If such products are used internally, the cannabinoid drug enters the brain to develop its effect on the nervous system. CBD acts opposite to the prominent THC: blocking and inhibiting. So it works instead of intoxicating and hunger stimulating, appetite suppressing, soothing and reducing heart rate.

appetitzügelnd

reassuring

Lowering heart rate

It stimulates the body's own receptors in the brain, without triggering intoxication states. In addition, it can to a certain extent also be regarded as a natural antidote to tetrahydrocannabinol, since it can dampen and regulate its effects and, of course, counteracts some THC side effects. It also inhibits the uptake of THC, thus reducing its influence directly. For this reason, breeds of "intoxicant hemp" also deliberately reduce the proportion of CBD Five.

Medically, it has anticonvulsant effects and can be anti-inflammatory as well as anxiolytic and nausea.

Pharmacologically, it is possible for CBD to target different receptor systems (THC at only two), which is why it is considered effective and well-tolerated. For this reason, it can also be considered as a very safe component of the hemp plant.

#cbd #cbdoil #cbdlife #cbdheals

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vigrxwarning · 4 years

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erectile dysfunction cme

Contents

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greatestlcve · 4 years

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Stablon Tablets Reviews Uses, Dosage, Side Effects,Warnings and Precautions

Drug Online

stablon drug >> Generic drug of the therapeutic class: Neurology – psychiatry active ingredients: Tianeptine

what is stablon ?

This drug is recommended in depressive states of mild, moderate or severe intensity.

Stablon Tablets indication and Uses

Major depressive episodes (ie characterized).

stablon drug Dosage

The recommended dosage is 1 tablet at 12.5 mg three times a day, morning, noon and night, at the beginning of the main meals.

In chronic alcoholic, cirrhotic or non-cirrhotic, no dosage modification is necessary.

In patients over 70 years of age and in case of renal insufficiency, limit the dosage to 2 tablets per day.

Contraindications

Tianeptine hypersensitivity

Child under 15

Teenager aged 15 to 18

Fructose intolerance

Glucose malabsorption syndrome

Galactose malabsorption syndrome

Sucrase-isomaltase deficiency

Hypersensitivity to the active substance or to any of the excipients listed in section composition.

Children and adolescents under 15 years old.

How it works Stablon Tablets

Pharmacotherapeutic group: OTHER ANTIDEPRESSANTS.

ATC Code: N06AX14.

Tianeptine is an antidepressant:

In animals, tianeptine has the following characteristics:

Tianeptine increases the spontaneous activity of pyramidal cells of the hippocampus and accelerates their recovery after functional inhibition,

Tianeptine increases serotonin reuptake speed by neurons of the cortex and hippocampus.

In humans, tianeptine is characterized by:

A clear activity on somatic complaints, in particular digestive complaints related to anxiety and mood disorders.

Tianeptine also has no effect:

On sleep and vigilance,

On the cholinergic system (absence of anticholinergic manifestation)

Stablon Side Effects

Stablon Tablets Side Effects

Summary of the security profile:

The adverse effects seen with tianeptine in clinical trials are of moderate intensity. They consist mainly of nausea, constipation, abdominal pain, drowsiness, headache, dry mouth and dizziness.

Table of adverse effects

The following adverse reactions have been observed in clinical trials and / or the post-marketing use of tianeptine and are classified according to their frequency:

Very common ( ³ 1/10); frequent ( ³ 1/100, <1/10); uncommon ( ³ 1/1000, <1/100); rare ( ³ 1/10000, <1/1000); very rare (<1/10000), undetermined (can not be estimated from the available data).

Organ-Class System (SOC)

Frequency

Side effects

Metabolism and nutrition disorders

Frequent

Anorexia

indeterminate *

hyponatremia

Psychiatric disorders

Frequent

nightmares

Rare

Abuse, addiction, especially in subjects under 50 years of age with a history of drug dependence or alcohol dependence

indeterminate *

Idiosyncratic cases and suicidal behavior have been reported during treatment with tianeptine or shortly after discontinuation (see section 4.4).

Confusional state, hallucinations

Nervous system disorders

Frequent

Insomnia

Drowsiness

Dizzying sensations

headaches

presyncope

tremors

indeterminate *

Extrapyramidal disorders

dyskinesia

Heart conditions

Frequent

tachycardia

premature

Chest pain

Vascular disorders

Frequent

Hot flashes

Respiratory, thoracic and mediastinal disorders

Frequent

Dyspnea

Gastrointestinal disorders

Frequent

Gastralgias

Abdominal pain

Dry mouth

nausea

vomiting

Constipation

flatulence

Skin and subcutaneous tissue disorders

Rare

Maculopapular or erythematous rash

itching

Urticaria

indeterminate *

Acne

Exceptional bullous reactions

Musculoskeletal and systemic disorders

Frequent

myalgia

Low back pain

General disorders and administration site abnormalities

Frequent

Asthenia

Sensation of discomfort in the throat

Hepatobiliary disorders

indeterminate *

Increased liver enzymes

Hepatitis can be exceptionally severe

* Post-market data

Stablon Tablets Interactions

Associations advised against

Irreversible MAOIs (iproniazid): because of the risk of collapse or paroxysmal hypertension, hyperthermia, convulsions, death.

Stablon Tablets Warnings and Precautions

Special warnings

Prolonged use and high doses can lead to a state of dependence.

Do not exceed the recommended dosage.

Suicidal ideation and worsening of your depression or anxiety disorder

If you suffer from depression and / or anxiety disorders, you may sometimes have ideas of self-aggression (aggression towards yourself) or suicide. These events may be increased at the beginning of antidepressant treatment, as this type of medication does not act immediately but only after 2 weeks or more of treatment.

You are more likely to exhibit such events in the following cases:

if you have ever had suicidal thoughts or self-aggression in the past.

if you are a young adult. Clinical studies have shown that the risk of suicidal behavior is increased in adults under 25 with psychiatric illness and treated with antidepressants.

If you have suicidal thoughts or self-aggression, contact your doctor immediately or go directly to the hospital.

You can get help from a friend or relative, tell them you’re depressed or have an anxiety disorder, and ask them to read this leaflet. You can ask him to tell you if he thinks your depression or anxiety is getting worse, or if he’s worried about a change in your behavior.

Due to the presence of sucrose, this drug should not be used in cases of fructose intolerance, glucose-galactose malabsorption syndrome or sucrase-isomaltase deficiency (rare metabolic diseases).

Precautions for use

Do not stop treatment abruptly, but decrease dosage for 7 to 14 days.

If you have to have a general anesthesia, you should tell the resuscitator anesthesiologist who will be able to stop the treatment 24 or 48 hours before the procedure.

Tell your doctor in case of kidney failure.

IF IN DOUBT, DO NOT HESITATE TO ASK YOUR DOCTOR OR PHARMACIST FOR ADVICE.

Drive and use machines

In some patients, a decrease in alertness is likely to occur. Attention is therefore drawn to the risk of drowsiness associated with the use of this drug, especially for vehicle drivers and machine users.

stablon drug and PREGNANCY / BREAST FEEDING / FERTILITY

stablon in Pregnancy

Maintaining a good maternal psychic balance is desirable throughout pregnancy. If medication management is necessary to ensure this balance, it should be instituted or continued in an effective dose throughout pregnancy and if possible in monotherapy.

The animal data are reassuring, but the clinical data are still insufficient.

Given these data, it is best to avoid using tianeptine during pregnancy, regardless of the term. If it is essential to initiate or maintain treatment with tianeptine during pregnancy, consider the pharmacological profile of the drug for monitoring the newborn.

Breastfeeding

Tricyclic antidepressants are excreted in breast milk, so breastfeeding is not recommended for the duration of treatment.

Fertility

In rats, one study showed a decrease in reproductive performance in females (increased preimplantation losses) at maternotoxic dose.

The clinical impact is not known.

What happens if I overdose from Stablon Tablets ?

sYMPTOMS

Experience with cases of acute tianeptine intoxication (maximum quantity: 2250mg, ingested in a single dose) mainly highlights vigilance disorders that can go as far as coma, particularly in cases of multiple intoxications.

To behave

Tianeptine has no known specific antidote. In cases of acute intoxication, symptomatic treatment and routine surveillance should be established. Specialized medical monitoring is recommended.

What is Forms and Composition?

FORMS and PRESENTATIONS

12.5 mg coated tablet (white): Box of 28, in blister packs.

Hospital model: Box of 100, in blister packs.

COMPOSITION

p cpTianeptine (INN) sodium salt12.5 mg

Excipients: D-mannitol, corn starch, talc, magnesium stearate. Coating:ethylcellulose, glycerol oleate, Sepifilm SE 700 white (povidone, carmellose sodium, anhydrous colloidal silica, talc, sucrose, polysorbate 80, titanium dioxide, sodium bicarbonate), white beeswax.

Excipient with known effect: sucrose.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

It treats possible side effects and drug interactions that require attention and its effect on continuous use.

The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

The post Stablon Tablets Reviews Uses, Dosage, Side Effects,Warnings and Precautions appeared first on Drug Online.

from Drug Online https://bit.ly/32XeKrM via Edrug Online from Faculty of Medicine https://bit.ly/32h0EPP via Internal Medicine

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marketreports3 · 4 years

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Research On World Antidote Market Report 2025

Report on World Antidote Market by Product Type, Market, Players and Regions-Forecast to 2025 by DecisionDatabases.com

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Global Antidote Market: Product Segment Analysis

Chemical Antidotes

Physical Antidotes

Pharmacological Antidotes

Global Antidote Market: Application Segment Analysis

Pesticide Poisoning

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abrreports-blog · 4 years

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Antidote Market Key Trends, Drivers, Growth Opportunities, and 2025 Industry Chain Structure Analysis

The research study Antidote market 2020 launched by ABRReports.com provides the detailed analysis of current market status, investment plans, production and consumption, price trends, leading key companies, growth drivers and future prospect. The base year considered for the study is 2019, and the market size is projected from 2020 to 2025

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The segmentation of Antidote study as mentioned below:

By Market Players:

Boehringer Ingelheim Pharmaceuticals, AstraZeneca, Novartis International, Eli Lilly, Portola, Pfizer, Bristol-Myers Squibb, Bayer

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Animal Bites, Heavy Metal Poisoning, OthersChemical Antidotes, Physical Antidotes, Pharmacological Antidotes

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Chapter 3 Production Market Analysis

Chapter 4 Sales Market Analysis

Chapter 5 Consumption Market Analysis

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Chapter 7 Major Manufacturers Production and Sales Market Comparison Analysis

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Chapter 10 Global and Regional Market Forecast

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Chapter 12 New Project Investment Feasibility Analysis

Chapter 13 Conclusions

Continued…

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