#Xiang-LEE
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Someone special is visiting Jinzhou!
Definitely not because he was so lost he jumped universe. Definitely not that.
And no need to worry, Lee is with Yao right now. Xiang-LEE tasked to give Punchy a little tour around the village while their owners figuring out how to send Lee back.
#i give up#steal a background from ibis because i tried make my own and failed#when will my painting skill improve sob#anyway Xiang-Lee and Punchy are equally cute#so do their owner#kuro games#wuthering waves#wuwa#pgr#punishing gray raven#xiangli yao#lee hyperreal#kurorenji'sart#Xiang-LEE#Punchy PGR
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self indulgent xiangli thỏ
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I'm always a sucker for a kung fu jiangshi, but it's actually not as common a thing as you'd think...
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omg coco your boyfie got his white day art! 🥺
#bisous!#༼;´༎��� ༎ຶ༽ ༼;´༎ຶ ༎ຶ༽ ༼;´༎ຶ ༎ຶ༽ !!!!!!!!!!#official wuwa xiangli yao content… in This economy…. oh my gosh.#oh my gosh it’s xiangli & xiang-lee they are wrapping a gift 💝 :3 so cuuuuuute!!!!!!!#🥺🥺🥺🥺🥺🥺🥺🥺🥺 his cheeks… there is so much cheek to be pinched kai i think we should do it together!! 😼🤏 oh my godh TAT#Xiangli…..my xiangli……….. 🥹💗 it’s such a beautiful blessed day. and it’s pi day on top of that Yay!!!!!!!!#i’ll give you lots of pi shaped cookies kai for showing me this 🍪 :3 thank you so muuuuuch!! for thinking of me sob!! TAT#my ultimate cutie 🤗
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"I'm tired of others deciding my story for me."
"Xiang," in Clash of Steel: A Treasure Island Remix by C.B. Lee
#xiang#lgbtqia#queer#queer literature#lesbian characters#treasure island#clash of steel#cb lee#destiny#deciding my story for me#writing#quote#writeblr#fiction writing#novel writing#writing tips
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people i NEEEEEED brian laborn to meet:
xiang from reboot.exe (first ever brian with a girl best friend. they can talk about martial arts and motorcycles)
iida tenya from bnha (i think iida's autistic swag would click well with brian's brian nature. mutual respect. also brian would find out about iida's brother's injury + its effect on iida and get incredibly concerned which is fun)
samin lee from hand jumper (superpowered kids raised by "hard" parents who assumed sole responsibility for their little sisters from a young age and ran a criminal gang to provide for them, but accidentally kind of a little bit became like their parents. twisted mirror situation. brian is doing better than samin though ngl)
on the sibling front i think he'd respect eve from birdie wing ngl. mutual recognition of a similar situation
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My Top Male Characters of 2023
#One piece live action#opla#monkey d luffy#Danger zone: the dark night#lian yan dong#destined with you#jang shin you#Tale of the nine tailed 1938#lee yeon#lee rang#a familiar stranger#xiao han sheng#I'm tee me too#Maitee#maetee#t-rex#My lethal man#fang xiang#yuan shuai#Fuujinshi#osagami kakeru#the forbidden marriage#lee heon#kdrama#korean drama#jdrama#japan drama#cdrama#chinese drama#taiwan drama
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May 2025 TBR
First book of the month already on page 57 and yikes...many things have happened.
Didn't get to these in April...alas (21-30)
(The comic!)
#May 2025#TBR#booklr#The Demon Awakens#r.a. salvatore#Animoprhs#The Secret#k.a. applegate#Whiskers and Smoke#Marian Babson#Never Fade#Alexandra Bracken#Blood-C#CLAMP#Ranmaru Kotone#Rules of Ascension#David B. Coe#Naruto#Masashi Kishimoto#Pahua and the Soul Stealer#Lori M. Lee#Song of the Six Realms#Judy I. Lin#Grandmaster of Demonic Cultivation#Luo Di Cheng Qiu#mo xiang tong xiu#Before She Ignites#Jodi Meadows#Certain Dark Things#silvia moreno garcia
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youtube
I didn't follow this survival show at all, but I heard the final group would have Lee Haein as creative director, and that was enough to make me curious about their debut. Turns out, I actually love it! They went for a sound that's pretty unusual among the new gen boy groups, and the whole album has such a cohesive sound and identity. I'll be keeping an eye on them, for sure!
#the mv is beautifully made too#knew lee haein wouldn't disappoint#close your eyes#jeon minwook#ma jing xiang#jang yeojun#kim sungmin#song seungho#sakurada kenshin#seo kyoungbae#lee haein#kpop
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Listen. I'm officially Xiang-LEE's fan now.









Gshsjsjj can't believe Kuro really bring CUB here. Maybe in the future we gonna have CUB to help us fight, like in PGR. I'm 100% pulling for Xiang-LEE if that happens and he's up in the banner.
#kuro games#wuthering waves#wuwa#pgr#punishing gray raven#wuthering waves journey#xiangli yao#Xiang-LEE wuwa
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Book recs?
Hey capri community! I would love to hear some book recs from you! Setting: prefer fantasy/otherworldly/period over the real current world.
Gender doesn't really matter, there can be romance and spice (slowburn is always fun). Can have darker topics if done well.
Most importantly I really want to feel what the characters experience. Can be love/deep connection, fear/panic or whatever emotion but I want to gasp or laugh when reading… It's really hard to describe.
Pacat gave all that to me, but it's hard to find in other books so far. (Freya's A Marvellous Light was one of the ones that managed to do it, the second book less so tho, haven't read the third yet.)
So if anyone has a recommendation, please drop it in the comments. 👉👈 ----------------------------------------
EDIT: OMG thank you so much for all the recommendations! I compiled them in alphabetical order, so other people can refer to the list in case they need a recommendation as well:
A-Z (☑ read / ☐ not yet read /📜 currently reading)
☐ A Ballad for slayers & Monsters - Rita A Rubin ☐ A bone in his teeth - Kellen Graves ☐ A Gentleman's Guide to Seducing a Scoundrel - KJ Charles ☐ A Master of Djinn - P. Djeli Clark ☐ A Spear cuts through water - Simon Jimenez ☐ A Strange and Stubborn Endurance - Foz Meadows ☐ A taste of Gold and Iron - Alexandria Rowland ☐ All for the game - Nora Sakavic ☐ Angels & man - Nicolás Rafael ☐ Angels before man - Nicolás Rafael ☐ Ballad of Sword and Wine: Qiang Jin Jiu -Tang Jiu Qing ☐ Beacon Hill Sorcerer series -Sheena Jolie ☐ Blood Over Bright Haven - M. L. Wang ☐ Crier's War - Nina Varela ☑ Dark Rise - C.S.Pacat ☐ Glitterland - Alexis Hall ☐ Heaven Official's Blessing Mo Xiang Tong Xiu ☐ Iron Breakers Trilogy - Zaya Feli ☐ Long Live Evil - Sarah Rees Brennan ☐ Lymond Chronicles - Dorothy Dunnett ☐ Iron Widow - Xiran Jay Zhao ☐ Murderbot Series - Martha Wells ☐ Nightrunner Series - Lynn Flewelling ☐ of Knights and Books - Rita A Rubin ☐ Parasol Protectorate - Gail Carriger ☑ Priory of the Orange Tree - Samantha Shannon ☐ Realm of the Elderlings/Farseer Trilogy - Robin Hobb ☐ Reforged - Seth Haddon ☐ Scum villain's self saving system - Mo Xiang Tong Xiu ☐ Shades of Magic -V.E. Schwab ☐ Silver Blood - TL Morgan ☐ Simon Snow Trilogy - Rainbow Rowell ☐ Six of Crows - Leigh Bardugo ☐ Skulduggery pleasant - Derek Handy ☑ Something Human - AJ Demas ☑ Song of Achilles - Madeline Miller ☐ Song of the bullrider - Alex "Muun" Singer ☐ Swordcrossed -Freya Marske ☐ Sword Dance -A.J. Demas ☐ The Alexander Trilogy - Mary Renault ☐ The Binding - Bridget Collins ☐ The Crossroads trilogy - Kate Elliott ☐ The Darkness Outside Us - Eliot Schrefer ☐ The Goblin Emperor - Katherine Addison ☐ The Grandmaster of demonic cultivation (Mo Dao Zu Shi) - Mo Xiang Tong Xiu ☑ The Gentleman's Guide to Vice and Virtue - Mackenzi Lee ☐ The Hair Carpet Weavers Andreas Eschenbach ☐ The Hands of the Emperor - Victoria Goddard ☐ The husky and his white cat - Rou Bao Bu Chi Rou (check TW) ☐ The Hyperion Cantos - Dan Simmons ☑ The Last Binding Trilogy - Freya Marske ☐ The Left Hand of Darkness - Ursula K. Le Guin ☐ The Magpie Ballads- Vale Aida ☐ The Magpie Lord Series- Kj Charles ☐ The Queen's thief - Megan Whalen Turner ☐ The Queer Principles of Kitt Webb - Cat Sebastian ☐ The Raven Cycle by Maggie Stiefvater 📜 The Rifter Series - Ginn Hale ☐ The Scottish Boy - Alex de Campi ☑ The Tarot Sequence Series - K.D. Edwards (check TW) ☐ The Traitor Baru Cormorant -Seth Dickinson ☐ The Winner's Curse - Marie Rutkoski ☐ Tiger, Tiger - Petra Erika Nordlund (Webcomic) ☐ Will Darling Adventures - KJ Charles ☑ Winter’s orbit - Everina Maxwell ☐ Untamed - Anna Cowan
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what's not to love about xiangli yao
genre: fluff, headcanon
character: xiangli yao
a/n: my heart was stolen and sadly enough, i'm not loyal to jiyan anymore😔
He's such a gentleman.
I can see him as someone who's really sweet and caring towards his partner.
The type that would definitely bring flowers to your first date. Then, buys different gifts that you would like once he's gotten to know you better.
He has a list of the things you're interested in based on your conversations with him—whether it'd be games, books, shows, etc. He memorizes them so he can give gifts later.
If it's not obvious enough, his love languages are gift giving and quality time.
No matter how busy he is, or how he loves to be couped up in his lab, he will make time for you.
You need him to pick you up? He's on his way. You need necessary items? He's checking out. Need cuddles and attention? Yes please, consider it done.
He wouldn't mind you coming to his workplace, he'll let you stay in the lab while he does his research.
The one time you accidentally knocked his crucible off the table your heart dropped.
He saw your scared expression—your eyes so shiny with your tears begging to stain your cheeks—but he never had the intention to yell at you like you were a kid to begin with. He knows better that it was all an accident.
He approached you and there you started rambling about how it happened and apologized repeatedly until he picked up both your hands and asked, "Are you hurt?" with the most gentle voice you've heard and a worried look. You melted!
He loves to secretly and not-so secretly take pictures of you. He has a camera specifically for you only.
He loves to make plans ahead—for tomorrow, next weekend, next month, heck, even next year and years ahead. He even slipped out his plans of getting married to you and having kids and such. Boy, you never thought it was possible to see how red he can be.
He's always so calm and keeps a cool head. Even when you're yapping about your day and such, he'll attentively listen to you. However, his habit of watching you talk always gets to you and annoyingly, he doesn't get it. His face would look so soft, his gaze is gentle and he always puts a smile.
"Don't look at me with those eyes!" "What eyes?" Definitely happened.
He just can't help it. The way you get excited, or have that angry pout, it was all too adorable for him. He's just so in love with you.
If you're the one to tease him, expect lots of stutters and blinking eyes. He can hide his blush all he wants but the sudden silence and avoiding eye contact are obvious hints he's flustered.
When you patted Xiang-LEE's head when you are fully aware that Xiangli Yao was taking control, he went speechless and stumbled with his words.
But when you patted his actual head, he malfunctioned. He could not maintain eye contact with you at all after that.
Another thing he loves is when you play with his soft hair, but he gets way too shy the whole time no matter how hard he tries to stay calm. If he feels comfortable enough to succumb to the embarrassment, he buries his head into the crook of your neck to hide his blushing face.
If you tease him too much, he might actually burst his bubble.
#wuthering waves#wuwa#xiangli yao#wuwa xiangli yao#xiangli yao x reader#xiangli yao x rover#xiangli yao fluff#xiangli yao headcannons#xiangli yao headcanons#wuthering waves xiangli yao
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Within Your Eyes Intro Post
DEMO [Last Updated June 22nd, 2024]
You are a Warden, a monster hunter who has come to the Kingdom of Auris which has become the forefront runner in it’s acceptance of magic and supernatural alike within the West Highlands. But when strange happenstances occur, you are called upon not just because of skill, but also because of your condition. A condition you’ve lied about for last 12 years.
Unearth the secrets that magic holds as a new form is discovered.
Befriend or romance those who attempt to worm through the cracks of the mask you wear. Or will you fight to keep them at arms length?
Regardless of where your journey takes you, your feathered friend will be at your side. As he always has been.
This story will be 18+ for the following reasons:
Explicit and erotic intimate scenes
Death, including of a child
Violence, blood and gore
Thoughts of suicide
Mentions of suicide
Self harm
Explicit language
Mental trauma
Horror elements
Feelings of being watched
NOTE: Your character will be pretending to have a disability (blindness), not because of a disorder but out of self preservation.
This list may be updated.
You are running away from your past. As you take a this new job, you're forced to confront it. What vices do you use to cope? Will you learn to rely on others or will your raven be your only source of comfort? Will you feel guilty for your lies? Yours will be a journey of self-forgiveness, or maybe you'll only fall deeper into despair.
Play as a man, woman, or non-binary. Gay, straight, or bi.
Plenty of customization options from physical appearance to clothes.
Φ Admos de Le Wren ─ Male | Draconian | Second-Born
Admos, the Dragon Lord of Auris, ascended to the throne following a devastating conflict with his father, bypassing his older brother's claim. This decision deepened the rift among his siblings. As he enters his fifth year as sovereign, Admos grapples with guilt and uncertainty about his role in the family's discord. Will you help him find clarity or fuel his doubts?
Φ Lyth/Lyari de Le Wren ─ Gender Selectable | Draconian | Tenth-Born
Ly took on the role of Viceroy/Vicereine in Auris and became their brother Admos's Right Hand, playing a vital part in the kingdom's recovery after a conflict with their father. However, an incident they triggered over a year and a half ago almost led to another war, casting doubt on their suitability for their position and their aid to their brother. Will you help Ly grapple with their past actions and uncertainties about their role as Viceroy/Vicereine, or will their internal conflicts remain unresolved?
Φ Leese/Lea van Laere ─ Gender Selectable | Human | Vampire
Born into nobility, Lee's life as the child of prominent figures in Lenia took an unexpected turn when they were turned into a vampire. Forced to leave their home, Lee now wrestles with their new identity, desperately seeking meaning in their existence and if it's worth maintaining.
Is Lee a monster consumed by instinct, or can you help them reclaim their humanity?
Φ Xiang Xiaowen/Xiaodan ─ Gender Selectable | Human
Xiao, an ambassador dispatched to Auris to aid the Dragon Lord in Council matters, fought hard to secure their role. Serving as an unofficial advisor, they frequently share insights to assist Admos. Yet their unwavering dedication to obtaining this position hints at a deeper motivation. Perhaps they will reveal it to you.
Φ Gabriel Duarte ─ Gender Selectable | Human
Assigned to you as an assistant of sorts, the recently knighted guard is searching for their place within the Order. Perhaps their new mission will set them on a path for glory, or sink them beneath the turmoils it takes to obtain.
Φ Hestia ─ She/They | Elf? | Witch
Even the most kind have their secrets.
Φ Elies de Le Wren — He/Him | Draconian | Exiled Prince
.
Φ Harus Emery — He/Him | Half-Draconian Half-Human | Warden
Poly Routes: Lyth/Lyari and Gabriel | Leese/Lea and Gabriel | Xiaowen/Xiaodan and Hestia
Love Triangle: Admos and Elies (Note: Will not be resolved in poly. Don't overthink it.)
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FAQ
Romance Information Post
Ko-Fi
Tumblr Asks are disabled for the time being.
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WYE will always be free with chapters released once they are finished.
This is a planned trilogy.
Thank you for reading and for your support! ♥
#interactive fiction#within your eyes if#text based game#text based adventure#twine game#twine wip#twine interactive fiction#twine if#twine story#cyoa#interactive game#interactive novel#twine games
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familiar — xiangli yao x rover!reader
Anxiety knocks on the door of your chest. One, two, three.
You're not sure what to expect, really. It's only a simple meeting with the Principal Investigator of Huaxu Academy. After hearing all of his memorable achievements, as well as his kind-hearted nature, your body somehow shook.
Who was he? Why did your body react like that when you first heard his name? Did you know him?
As far as you know (or what the Magistrate, or the Counselor, or even your friends in Jinzhou), you've never even met before. Granted, if you were long awake before your time now, then you've never ever crossed paths.
When you ponder though, a white line seeps into your mind. Your body, albeit shaking, remembers something you don't. It's an endless cycle of wanting to find out the reason, an itch you couldn't wait to scratch.
So why were you turning away from the door that leads you to the man you were waiting to meet?
“If you're not feeling well, we can reschedule.” Baizhi, after a long sigh, notices your plight, “Chief Xiangli Yao wouldn't mind.”
“N-no, I'm fine.” You breathe deeply, “I'm just...nervous.”
“Is this because of your body's reaction?” Baizhi asks.
��...yes,” you meekly admit, “I'm afraid I might not know what happens after we'd meet.”
“It's a normal response to stress. You either fight or flee from it. But if you tend not to face it, then how will you know the answer?”
You turn to look at Baizhi with flecks of tears in your eyes. She's right; if it's something that you've long wanted to do, yet still push it away, how will you understand what it is?
With one deep breath, you turn on your heel and push the door with wobbly hands. The sudden light blinds your eyes momentarily, before a series of tv screens face you.
A somehow medium-sized room, littered with tv screens and controllers. Dyed in the shade of blue, they gave you a calming feeling. But the target of today's agenda finally catches your eye.
A tall, blonde-haired man draped in blue, over with a white coat. You don't miss a grey-colored mechanical arm. His back faces you, but as soon as the door opens, you catch the sight of cerulean irises.
You hold your breath.
“Chief, we're here,” Baizhi announces, “I brought the rover as promised.”
And your heartbeat quickens.
Flashes of unnamed memories play in front of your eyes as the man approaches you. Even whispers of some distant memory begin to sing in your ear. When the principal investigator is in front of you and holds out his hand, the answer became clear as day.
“Hello, rover,” The pretty man greets, “It's finally nice to meet you. I've heard a lot of your feats.”
“...and I've heard a lot from you, too.” You manage to speak.
You notice the way your heart seems to leap out of your chest. Squeezing in the guise of yearning and anticipation, you could rip it out and present it to him if you could. Slowly reaching out until your hands reach, you feel tingly sensations from his touch alone.
“I am Xiangli Yao,” He said, warm cerulean eyes twinkling, “the Principal Investigator of Huaxu Academy.”
“...commanding for duty...”
“Xiang...lee...Xiangli,” You mutter, aware of the rush of ghost memories, “You can call me [Y/N].”
“...commandant...”
The sparkle in his eyes only intensifies. “[Y/N]. Have we...met before?”
“...we are the Gray Raven.”
“...No,” you softly smile, “But I would love to get to know you better.”
“Lee, welcome back.”
A sweet smile graces his lips. “As do I, then, [Y/N].”
“I'd love you in every universe,” the familiar voice whispers in your ear, flashes of the same cerulean eyes glancing at you, “as I long promised, Commandant.”
LOOK WHEN IS XIANGLI YAO RELEASED I NEED HIM (CARNALLY)
— starry down bad for lee/xiangli yao
i wrote this pre his reveal so sorri if it seems ooc kek but the fact stands that he is lee expy and i am gonna simp no matter what i love lee in every universe
SCREAMING CRYING

#punishing gray raven#pgr#pgr lee#pgr hyperreal#wuthering waves imagines#wuthering waves#wuwa#punishing gray raven imagines#wuthering waves xiangli yao#wuwa xiangli yao
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Celebrate J.R.R. Tolkien’s Birthday with 54 Queer Fantasy Books!
Today, January 3rd, is J.R.R. Tolkien Day—the day we celebrate the legend’s birthday. It’s hard to imagine the fantasy genre without Tolkien’s influence on it. That’s why, we figured, what better way to celebrate than by having an adventure with an awesome fantasy book? And, as this is the first time we’ve done a queer fantasy rec list, our reccing crew got very excited, with the result that this is one of the longest lists we’ve ever posted. We asked our contributors for great queer, fantasy recommendations, and boy, did they deliver! We collected a list of whooping 54 titles, all thanks to Sanne, Kelas, Shadaras, Nina Waters, Shea Sullivan, E. C., Adrian Harley, Alex, D. V. Morse, Zel Howland, Shannon, Dei Walker, Linnea Peterson and an anonymous contributor.
Grandmaster of Demonic Cultivation by Mo Xiang Tong Xiu
Fire Logic by Laurie J. Marks
The Order of the Pure Moon Reflected in Water by Zen Cho
The Black Tides of Heaven by Neon Yang
The Angel of the Crows by Katherine Addison
The Witch King by H.E. Edgmon
Legendborn by Tracy Deonn
Witch King by Martha Wells
The Raven Boys by Maggie Stiefvater
Heaven Official’s Blessing by Mo Xiang Tong Xiu
The Witness for the Dead by Katherine Addison
The Husky & His White Cat Shizun by Rou Bao Bu Chi Rou
Swordspoint by Ellen Kushner
Devil Venerable Also Wants To Know by Cyan Wings
Ruin of Angels by Max Gladstone
The Priory of the Orange Tree by Samantha Shannon
A Strange and Stubborn Endurance by Foz Meadows
Call Down the Hawk by Maggie Stiefvater
Someone You Can Build a Nest In by John Wiswell
Ash by Malinda Lo
Shubeik Lubeik by Deena Mohamed
The Watchmaker of Filigree Street by Natasha Pulley
Rust in the Root by Justina Ireland
A Marvellous Light by Freya Marske
A Master of Djinn by P. Djèlí Clark
When the Angels Left the Old Country by Sacha Lamb
The Monsters We Defy by Leslye Penelope
The Starless Sea by Erin Morgenstern
Little Thieves by Margaret Owen
Siren Queen by Nghi Vo
The Spear Cuts Through Water by Simon Jimenez
The Ruthless Lady’s Guide to Wizardry by C.M. Waggoner
Reforged by Seth Haddon
The Traitor Baru Cormorant by Seth Dickinson
Luck in the Shadows by Lynn Flewelling
The Bone Doll’s Twin by Lynn Flewelling
Umineko: When They Cry by 07th Expansion
The Will of the Empress by Tamora Pierce
Witchmark by C.L. Polk
Lord of Eternal Night by Ben Alderson
These Witches Don’t Burn by Isabel Sterling
The Brilliant Death by A.R. Capetta
Consort of Fire by Kit Rocha
First Test by Tamora Pierce
Can’t Spell Treason Without Tea by Rebecca Thorne
The Thief by Megan Whalen Turner
Hench by Natalie Zina Walschots
The Gentleman’s Guide to Vice and Virtue by Mackenzi Lee
Carry On by Rainbow Rowell
Weak Heart by Ban Gilmartin
The Shepherd’s Crown by Terry Pratchett
Six Of Crows by Leigh Bardugo
Monstrous Regiment by Terry Pratchett
The Demon’s Lexicon by Sarah Rees Brennan
What are your favorite queer fantasy books?
You can find all these books on our Goodreads bookshelf of queer fantasy books.
Did something here spark your curiosity? You can buy it through the Duck Prints Press Bookshop.org affiliate shop.
So many books means so much to talk about! Come, join our Book Lover’s Discord server to chat with us about aaaaaall the books!
#duck prints press#rec list#j. r. r. tolkien day#book recomendations#fantasy books#fantasy recs#queer fantasy#queer book recs#queer book recommendations
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Needle-free COVID-19 intranasal vaccine provides broad immunity, study finds - Published Agu 27, 2024
A next-generation COVID-19 mucosal vaccine is set to be a gamechanger not only when delivering the vaccine itself, but also for people who are needle-phobic.
New Griffith University research, "A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants" published in Nature Communications, has been testing the efficacy of delivering a COVID-19 vaccine via the nasal passages.
Professor Suresh Mahalingam from Griffith's Institute for Biomedicine and Glycomics has been working on this research for the past four years.
"This is a live attenuated intranasal vaccine, called CDO-7N-1, designed to be administered intranasally, thereby inducing potential mucosal immunity as well as systemic immunity with just a single dose," Professor Mahalingam said.
"The vaccine induces strong memory responses in the nasal mucosa, offering long-term protection for up to a year or more.
"It's been designed to be administered as a single dose, ideally as a booster vaccine, as a safe alternative to needles with no adverse reactions in the short or long term."
Live-attenuated vaccines offer several significant advantages over other vaccine approaches.
They induce potent and long-lived humoral and cellular immunity, often with just a single dose.
Live-attenuated vaccines comprise the entire virus, thereby providing broad immunity, in contrast to a single antigen which is used in many other vaccine platforms.
Lead author Dr. Xiang Liu said the vaccine provides cross-protection against all variants of concern, and has neutralizing capacity against SARS-CoV-1.
"The vaccine offers potent protection against transmission, prevents reinfection and the spread of the virus, while also reducing the generation of new variants," Dr. Liu said.
"Unlike the mRNA vaccine which targets only the spike protein, CDO-7N-1 induces immunity to all major SARS-CoV-2 proteins and is highly effective against all major variants to date.
"Importantly, the vaccine remains stable at 4°C for seven months, making it ideal for low- and middle-income countries."
The vaccine has been licensed to Indian Immunologicals Ltd, a major vaccine manufacturer.
Dr. K. Anand Kumar, co-author of the publication and Managing Director of Indian Immunologicals Ltd. Said, "We are a leading 'One Health' company that has developed and launched several vaccines for human and animal use in India and are currently exporting to 62 countries."
"We have completed all the necessary studies of this novel COVID-19 vaccine which offers tremendous advantages over other vaccines.
"We now look forward to taking the vaccine candidate to clinical trials."
Professor Lee Smith, Acting Director of the Institute for Biomedicine and Glycomics, said he was delighted with the research findings.
"These results towards developing a next-generation COVID-19 vaccine are truly exciting," Professor Smith said.
"Our researchers are dedicated to providing innovative and, crucially, more accessible solutions to combat this high-impact disease."
More information: Xiang Liu et al, A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants, Nature Communications (2024). DOI: 10.1038/s41467-024-51535-y
#covid#mask up#pandemic#covid 19#wear a mask#coronavirus#sars cov 2#public health#still coviding#wear a respirator
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