#metoclopramide

[gpedia]

🤜🏼👁️👄👁️🤛🏼

EDIT: hey my old URL was still available!

[dancingplague]

Okay so it turns out that the downside of swimming is that because it's very gentle and keeps the temperature low enough to stave off the headache, I can overdo it a lot worse than I can walking or rowing. Kept swimming through a mild bout of vertigo this evening, then pulled myself out of the pool to discover that I was too dizzy to stand. Shook it off, got home, lay down, and suddenly found that I had an aura so severe I couldn't parse written sentences. Stood up to try a shower and got stabbed through the eye with a headache I've just now shaken after five hours in the dark. Whoops.

[l-tora-l]

saw this on pinterest 😭😭 (seems like we are in 2nd stage of infj life rn)

I WROTE A REPLY BUT TUMBLR ATE IT >:( lemme retype it up 😭

Omg 😭 this is so true, I'm constantly on tiktok nowadays and my FYP has recently morphed into having more mbti stuff and it's so addictive it's like "yep. *scrolls* yep. *scrolls* SO TRUE *scrolls*" whenever I see anything INFJ related 😭 then I try to see the MBTI results of people or characters ik and am like :000 OMG!!!

Yk what this reminds me of 🤧 my marketing course (🙄) we did the product life cycle and it had the introduction phase -> growth -> maturity -> decline phase. We are in the decline phase ☹️

[livealthbiopharma]

https://livealthbiopharma.com/products/metoclopramide-injection-bp-5-mg-ml/

[chemanalystdata]

Metoclopramide HCL Prices Trend in the second quarter of 2023 | ChemAnalyst

For the Quarter Ending June 2023

North America:

Metoclopramide hydrochloride prices in the United States displayed a mixed trend during the second quarter of 2023. In May, prices recorded a slight increase of 1.18%, driven by heightened demand from end-users and inventory replenishment activities. Fresh stock influx contributed to a bullish market scenario. However, the Manufacturing PMI (Purchasing Managers' Index) for May, registering at 48.4, signaled a slowdown in the U.S. manufacturing sector. This slowdown constrained the supply from manufacturers and suppliers due to reduced business activity. Despite this, robust consumer demand in May pushed metoclopramide hydrochloride prices higher. Conversely, prices experienced a decline of 4.23% in June compared to May, attributed to exceptionally sluggish uptakes in end-user industries. Domestic suppliers accumulated ample Metoclopramide Hydrochloride in their inventory, resulting in continuous price reductions in the domestic market. Furthermore, the high-interest rates imposed by the Federal Reserve dampened demand for metoclopramide hydrochloride, further contributing to the bearish trend. Additionally, the appreciation of the U.S. dollar against the Chinese yuan in June bolstered imports in the U.S. market, exerting additional downward pressure on Metoclopramide HCL prices.

Asia Pacific:

In China, prices for metoclopramide hydrochloride exhibited mixed trends during the second quarter. Prices increased by 1.21% in May compared to April levels, primarily driven by consistent demand in the domestic market and ongoing operational activity. China's Purchasing Managers Index (PMI) declined to 48.8 in May from 49.2 in April, signifying a slowdown in factory activity. This slowdown led to reduced inventories among market manufacturers and suppliers striving to meet strong market demand, resulting in upward price pressure. In contrast, metoclopramide hydrochloride prices fell by 3.21% in June compared to May, as new order follow-ups and consumer purchasing activity decelerated. The official Manufacturing Purchasing Managers Index (PMI) increased to 49.0 in June from the previous month's 48.8, indicating a slowdown in manufacturing activity. Decreased production was attributed to subdued end-user demand. Despite these fluctuations, prices remained relatively low as market participants held sufficient inventory to satisfy existing market demand. Additionally, Chinese exports experienced a 12.4% decline in June, contributing to increased metoclopramide hydrochloride availability in the Chinese market, further supporting the downward price trend.

Get Real Time Prices of Metoclopramide HCL: https://www.chemanalyst.com/Pricing-data/metoclopramide-hydrochloride-1388

Europe:

In Germany, the metoclopramide hydrochloride market exhibited mixed trends throughout the second quarter. Prices witnessed a slight increase of 1.19% in May compared to April, followed by a decline of 4.38% in June. May's price hike was influenced by limited stockpiles among traders and suppliers, along with heightened demand from end-user industries. The Manufacturing Purchasing Managers' Index (PMI) for Germany declined to 43.2 in May from April's 44.5, reflecting weaker business activity and lower inventories among market participants. Delays in shipments to meet demand contributed to the price increase of metoclopramide hydrochloride in May. In June, the German economy grappled with rising inflation and an interest rate hike by the European Central Bank, resulting in higher food and energy prices. This increase in the cost of living dampened consumer purchasing activity, further supporting the downward price trend for metoclopramide hydrochloride. Furthermore, the Euro's appreciation against the U.S. Dollar in June made imports cheaper and increased the supply of metoclopramide hydrochloride in the German market, amplifying the downward price pressure.

About Us: 

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[deliciouskeys]

“Metoclopramide remains the galactogogue of choice due to its documented record of efficacy and safety in women and infants. Domperidone crosses the blood brain barrier and into the breast milk to a lesser extent than metoclopramide, decreasing the risk of toxicity to both mother and infant possibly making it an attractive alternative.”

1. Coughing isn’t even listed as a possible side effect for this drug, so idk what was going on with Firecracker in the finale. Guess it was the easiest symptom to portray on screen? But this means she must be taking really high doses. Makes sense, since she has no endogenous prolactin going on presumably.

2. This drug crosses into the breast milk

3. Homelander is ingesting this milk and also getting a high dose of the drug (I couldn’t believe she has the baby bottles lined up on the Seven conference room table… like… I’m glad you’re out and proud Homelander but…)

…

4. You know where I’m going with this

ETA: before anyone says I’m stupid for thinking this drug can cause male lactation, what do you take me for, I checked that it’s on the list.

[exeggcute]

people are always trying to prescribe me metoclopramide but I'm like bro why is tardive dyskinesia a side effect of an antiemetic.

[doomspaniels]

The Lady of the Hour, Guinevere! Gwyn has had her long-awaited evaluation at the big teaching hospital. And folks, we have GOOD HELP, a PLAN, and NEW MEDS!

The internal medicine vet thinks we're looking at painful stretching of the bowel to cope with delayed gastric motility of some kind (he said, something similar to IBS-C but that's not diagnosable in dogs), and so going to improve gastric motility (meds similar to metoclopramide, but stronger) and soften the poop in the bowel with lactulose.

Getting there, however, took a looooong wait. To our astonishment, Tristan stepped up and worked hard on setting a good example for Gwyn. He booped her frequently, then would ostentatiously settle near her, inviting her to settle with him, and it kept working. (though she would jump up any time her Short-Attention-Spaniel was tickled by sounds or sights around us)

Eventually, of course, they "took Gwyn back" for tests, at which point Tristan became distressed and kept trying to go around to where she disappeared. He strongly disapproved of these strangers taking his baby sister. He did finally settle and snooze a little (and we played with some adorable cavaliers in the waiting room!)

LOOK AT THE PRECIOUS BOY.

At last my baby was returned to me, we got the aforementioned advice, and now we're home to implement the new meds. Awright!

[werehamburglar]

if firecracker is taking metoclopramide, i wonder if she's taking it for gerd, diabetes, other nausea reasons (or for something else not in the typical cache)

[nerdgirlnarrates]

It's battle of the macrolides for this matchup! Both these meds work by binding the 50S subunit of ribosomes, preventing translation. So who's better?

Azithromycin: The most prescribed anti-microbial in the US. It's a derivative of erythromycin with improved gram negative coverage as well as gram positive and atypicals coverage. Azithromycin's main game is the lungs, where it's useful for almost every pneumonia as well as COPD exacerbations; it's even used off-label as post-transplant prophylaxis for bronchiolitis obliterans. It is also considered to be safer than erythromycin with fewer adverse cardiac effects.

Erythromycin: Erythromycin has some unique applications, such as prophylaxis for gonococcal ophthalmia neonatorum, for which it is the only FDA-approved drug. However, its efficacy in this role has been called into question recently, with some--like the Canadian Paediatric Society--calling for a shift to maternal screening instead. Another unique application is as a treatment for gastroparesis. Though it's far from first line (and the American College of Gastroenterologists 2023 clinical guidelines for gastroparesis treatment don't even recommend it), it's been used off-label for gastroparesis since the 1990s. It was the first macrolide demonstrated to be a motilin receptor agonist, and so it became a favored alternative to metoclopramide. There are no randomized trials as of yet directly comparing the efficacy of azithromycin and erythromycin for gastroparesis, and so erythromycin remains the favorite by default. Unfortunately, it is more likely to prolong the QT interval than azithromycin.

P.S. for more fun, check out this paper on 10 controversies in gastroparesis

Vote for the best antibiotic

[l-tora-l]

TORAAAAAAAAA!!! HAPPY BIRTHDAY, MY DEAR STAR (LIGHT) ✨️✨️

LOOK WHAT'S HAPPENING ON YOUR WHATSAPP GROUP 🤭

hehe, I made you these cute picrew size drawings 🫶 doing anything for you is fun!!!! you're my cute little sister (≧▽≦). May god bless you with everything you ever wished for 💖 and oh yeah! most importantly, a healthy sleep schedule 😹✨️

love you 3000000 (｡•̀ᴗ-)✧

TRIS. I AM LITERALLY GONNA SOB THIS MADE MY ENTIRE CENTURY NO JOKE. Oh my God "star(light)" 😭LET ME OBSESS OVER THE WHATSAPP GC FIRST OF ALL 🥹

GOD THAT WAS SO SCARA CODED AND ALSO THAT IS LITERALLY SO IN CHARACTER FOR CHILDE AS WELL??? I ACTUALLY DIED AT THAT HONESTLY ID EAT EVEN THE BURNT CAKE IF THEY MADE IT 😭🫶✨

HELP NOT ALHAITHAM COMING IN WITH HIS MATH HES SO NONCHALANTLY INVESTED ( IDK HOW TO DESCRIBE HIS PERSONALITY PROPERLY BUT YEAH ) ✋😭 AND KAVEH TOO AHAHAHAJDJ HES SICK OF ALHAITHAM 😭 ( also the heart in his name I'm 🤭🫶✨)

AND TRIS I LITERALLY NOTICED THE TIMING OF THIS TOO 🥹 KAVEHS MESSAGE SENT AT 11:29 AND 🥹 AAAH ALL OF THIS IS SO PERFECT I LOVE YOU SO MUCH OMG ?!?

BLADE BEING ADDED TOO I BET HES JUST GONNA GRUMBLE AND SIT THERE, it's okay he can be the decor he's pretty :P AND KAZUHA 🥹 THE "TORAS ARMY OF BROKEN MEN" THING WE TALKED ABOUT TOO ✨

I LOVE THEM ALL DEARLY AND I LOVE YOU MOST OF ALL 😭🫂

ALSO THOSE PICREWS ARE SO SO ADORABLE!!! SISTERS FOR LIFE !!! 😼✨🫶🫂🌻 NDJWKSSNS NOT THE SLEEP SCHEDULE YOURE RIGHT THO I DEF NEED TO IMPROVE IT 😭

ME AFTER THIS :

[cannabiscomrade]

Can I ask how you came to be tube fed? Like what symptoms led to its consideration by you and a doctor, what was tried first (if anything) and how it failed? My mom is suggesting that I might wind up tube fed, but I can eat about a meal a day, and drink water, and only vomit every couple days. So I feel like a tube would be extreme, but I'm pretty much desperate for relief so. I don't know. I don't know much about it. Obviously don't answer these questions if they're too invasive!!

Everyone is different but for me my gastroparesis declined very quickly. I should have had a tube placed sooner than I did. I am pro nutritional intervention, even if temporarily, to stabilize patient symptoms.

I’ve always had difficulty eating and I would often vomit in the mornings every couple of days to once a week. I had a flare up that lasted a long time, from August to November, which led to my diagnosis at the beginning of November last year. I was put on the gastroparesis diet and I consulted with a dietitian and went on a mostly purée and liquid diet.

I was put on Metoclopramide (Reglan) which failed and they tried the nasal form (Gimoti), and I was intermittently getting IV Reglan, which ended up giving me TD and I had to stop it. We tried erythromycin, which also failed. I was also on Zofran which intermittently helped but started to not work, especially when I was waking up to vomit. I was still losing weight.

Then I got covid at the end of that November. I was classified as in gastric failure soon afterwards.

I couldn’t hold anything down food-wise from December 5th to January 5th 2023, which is when my tube was placed. Starting January 1st I couldn’t tolerate water and January 3rd I was admitted with starvation ketoacidosis. In total I lost over 60lbs in 4 months. I ended up in refeeding syndrome once we started feeds.

I’m not sure if you’re asking because you have gastroparesis too, but I’m assuming that’s the case, so I will address the treatment criteria. If you’ve lost more than 5-10% of your body weight involuntarily in less than 6mo and have failed medication intervention, a post-pyloric feeding tube should be considered for treatment.

[anderswasrightt]

today a patient was picking up some anti-nausea meds and i said, "okay so we have some metoclopramide?" like confirming what she was picking up

and she was like "yeah, WICKED morning sickness. don't ever get pregnant"

and i was like "haha i'll do my best to avoid that" and she started laughing

then i went back by my coworkers and one of them was like, "did she seriously just tell you not to get pregnant? does she know you're like..........(she seems to think saying "trans" and "gay" are not allowed in reference to me, a gay trans person)" and i said, "no she doesn't know i'm trans. luckily, i handled that pregnancy thing last year (when i had my hysterectomy)" and she burst out laughing. i am the funniest bitch in that pharmacy 💅🏻

[headpainmigraine]

Migraine isn’t a Headache Part Five: make it go away

I wanted to put something about getting diagnosed before I started to address medication, but the spoons to put my diagnosis journey together down on paper are much more than this section, so I’m skipping it until later.

(We’re out of Migraine Awareness Month now, but we are getting into Disability Pride Month, and chronic migraine is a disability, so!)

Treatment for Migraine can be divided into ACUTE and PREVENTATIVE

(and within that, can be divided into ‘medical’ and ‘complimentary’)

Acute treatment includes medication that treats the pain when you’re starting or having a migraine, like triptans, and methods you use to handle the pain, like cold packs

Preventative treatment aims to stop the migraine happening, so that you don’t need to use acute treatments.

Up until very recently (2021) there were no preventative treatments for migraine that were made specifically for migraine (until 2021)

(2021)

(That was three years ago.)

(Yeah)

Every other medication prescribed had originally been designed for something else.

As a result, you’ll find that a lot of suggested migraine preventative treatments are drugs used to treat things like high blood pressure, seizures and mental health issues like depression and psychosis – dosage makes all the difference.

This isn’t because they believe the cause of your migraine to be high blood pressure, or mental illness, but because the drugs also work to mitigate migraines – I’m only highlighting that because I’ve seen it suggested that when a doctor prescribes an antidepressant for migraines, it’s because they’re treating depression – this isn’t true.

Even botox was first used in beauty treatments before they discovered that women who had it also experienced a reduction in their migraines.

There have been no medications made specifically for migraine until the last couple of years, which is a crazy state of affairs.

And, even now, the meds that are coming out for migraine (CGRP mAb injections -nabs and -gepants) aren’t widely available, and not at all in some countries (India, for example). We don’t yet have access to the exciting new -gepant drugs in the UK.

(EDIT: As of 31st May 2023 we MIGHT be getting access to them! Exciting!)

When you present at the GP with a headache, and the GP diagnoses you with migraine, they won’t usually jump to prescribing preventatives.

They will usually prescribe acute medications first, if anything at all.

It’s not uncommon to be told to take high dose dispersible aspirin or other over the counter meds marketed for migraine.

These meds are usually your average ibuprofen or paracetamol with added caffeine, sometimes with an added anti-emetic.

Remember that migraines aren’t a headache, so your stomach can stop working or work inefficiently when you’re having one.

Prescribing an acute pain relief medication alongside an anti-emetic helps your body actually absorb that acute med while you’re having an attack.

In my experience, no GP ever suggested or prescribed an anti-emetic alongside an acute treatment when I first went to them with migraines, so be prepared to have to make that suggestion yourself, and to be shot down if they disagree.

The usual anti-emetics will be metoclopramide hydrochloride, or prochlorperazine (also used for schizophrenia and anxiety)

Sometimes, your GP will prescribe naproxen, or another prescription NSAID for your migraines.

If you’re lucky, your GP might prescribe a triptan.

I believe the most common is ‘sumatriptan’ but there are a whole host of them (rizatriptan and almotriptan might be two others you’ve heard about).

I’m currently taking eletriptan, which is a much older triptan and not widely used by most GP’s for some reason.

This to say, that if you’re prescribed eg sumatriptan and it doesn’t work for you, try asking for another type.

Another reason triptans might not work for you is the method of administration.

If your migraines present with a lot of vomiting, something that melts on your tongue or a buccal tablet that dissolves under your upper lip might work better for you than a tablet you swallow. Some of them even come in nasal sprays.

TL;DR – Acute Treatment - Medications

- Paracetamol

- Ibuprofen

- Aspirin (dispersible aspirin for fast absorption, 900mg best dose)

- Co-codamol (voted most likely to cause rebound headaches)

- Naproxen (prescription only)

- Triptans (prescription only?)

- Anti-emetics (metoclopramide, prochlorperazine)

- Other prescription NSAIDs (tolfenamic acid, diclofenac potassium, diclofenac sodium, mefenamic acid)

- US only? -gepants

You can’t take most of these medications indefinitely.

They recommend taking cocodamol no more than 3 days in a row because of risk of addiction.

You can’t take metoclopramide for a long time.

Almost all of these meds can cause rebound/medication overuse headaches

Not to mention the side effects these meds come with, or the stress you might be putting on your kidneys/liver/rest of your body.

When your pain is that bad that you CAN’T care about the risks of taking something that might make a little dent in the agonies, you don’t think about those risks.

The hard part is that you get to the point where you HAVE TO start thinking about those risks.

Taking painkillers all day every day every time isn’t sustainable.

I know, it sucks.

Maybe in the future they’ll come up with a painkiller we can take that will reduce the pain without side effects destroying your body, but we’re not there yet.

Just another happy part of being alive as someone with chronic pain!

BUT! That’s where ‘complimentary’ treatments come in. These come in preventative and acute flavours too, with a lot of overlap, but we’re looking at acute treatments this time around.

If you’re a long-term chronic pain patient, you’ll probably already know about all of these.

I covered “lifestyle changes” that might help headaches in THIS PART, and you can use those here (sticking to a sleep schedule, regular meals, staying hydrated, ugh, yeah, I know, it helps though), but, for more urgent relief:

***Little disclaimer, not everything will work for everyone. Maybe you have other conditions that contraindicate these ideas. I’m not a medical professional, just a dude who suffers and uses this stuff to suffer a little less.***

- Cold treatment (ice packs, sticky cold patches, running cold water over your head, cold swimming, cold gels in a tube, ice hats)

- Heat treatment (electric heat pads, microwaveable heat packs, sticky heat patches, hot water bottles, hot baths)

- Balms (tiger balm, roll-on headache gels, pulse point gels, menthol rubs)

- Aromatherapy (helpful sometimes, but just as likely to aggravate your migraine as not. Proceed with caution.)

- Hot drinks (I don’t know why, but a cup of hot chocolate really takes the edge off my migraines?)

- Cold drinks, with ice

- Massage/Muscle treatments (anything from muscle relaxant bubble baths to massage rollers to getting someone to rub your back for you, if you’re lucky enough to have someone willing to do that)

- Gentle stretching (you can find a lot online; look for post-operative/elderly/low impact stretches)

- Sleep masks/Sunglasses (get away, light!)

- Travel sickness pills or ginger caplets for nausea

- Acupuncture (there is a point between the index finger and thumb in the meat of your hand that is supposed to ease pain if you add pressure to it – it doesn’t really work for me, but it’s worth a try. I’d suggest Googling/YouTubing it. I have acupuncture needles and have been shown how to use them, so it might be worth asking if you know a practitioner you trust?)

I’m sure I’m missing something that will come to me later.

For travel, I take:

- painkillers and my triptans (and anti-emetic when I’m allowed to have one)

- travel sickness pills/ginger pills

- balm tin/roller

- cold balm/sometimes cold patches

- shades

I’ve also shaved my head – I usually go down to a Grade 1, but have gone 0 before, which was weird.

Hair grows back surprisingly fast, and having short hair is amazing for migraines, especially in the summer.

You don’t need to spend so much time washing/drying your hair (which is helpful when you’re in the midst of an attack and/or have comorbidities that make showering difficult).

You can also apply cold/heat treatments closer to the scalp, but be careful not to burn yourself (I am absolutely not speaking from experience…)

On a greater scale, just making your room (or wherever you go to hide when you have migraines) as comfortable for you as possible is helpful. Enough pillows, blankets you can kick off if you overheat, a fan to keep the room cool but not cold, curtains or blackout blinds depending on how much light you want to block out.

I use a text-to-speech app to read fanfic to me, or I listen to audiobooks when I’m being photosensitive but can manage sound, and don’t want to be bored out of my gourd.

Has anyone else got any other tips that don’t fall into the above categories for help when you’re having a migraine?

Next up in this series: Preventative Treatment (Meds and Complimentary Treatments)

[innko]

horrid horrid migraine last night and taking benzos and metoclopramide and sleeping (only about 5 hours) did end it damn metoclopramide works well but i call it my evil nausea pill for a reason i’m terrified of the potential adverse effects

i use it as sparingly as possible and only ask the doctor to give me 5 pills a visit

[rosen-dovecote]

Begging, and hoping, and pleading that the amount of food I ate last night isn't sending me into another flair, even though I stayed up the right amount of time after eating to make sure- and that a Metoclopramide will take care of what's left. But it's not feeling that way and I hate ittt 😭

ETA: An hour and a half into this nonsense, after being woken up burping and being in pain again and taking a Meto for it, and I still feel horrid. I think I'm going to have to throw it up 😭 I'm going to try Tea now to see if it helps, but I really have no faith.

I'm so annoyed, too, because I really thought I'd ended the Gastritis Flair from a month back. I hadn't had any issue for weeks!

ETA2: Tea may have actually worked. I'm going to try laying back down now finally. Fingers crossed 🤞 Because I've been up since, like, 4:30 am.